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Aliases for DNMT1 Gene

Aliases for DNMT1 Gene

  • DNA (Cytosine-5-)-Methyltransferase 1 2 3 5
  • CXXC-Type Zinc Finger Protein 9 3 4
  • DNA Methyltransferase HsaI 3 4
  • DNA MTase HsaI 3 4
  • EC 2.1.1.37 4 63
  • M.HsaI 3 4
  • CXXC9 3 4
  • DNMT 3 4
  • MCMT 3 4
  • AIM 3 4
  • ADCADN 3
  • HSN1E 3
  • Dnmt1 4

External Ids for DNMT1 Gene

Previous HGNC Symbols for DNMT1 Gene

  • DNMT

Previous GeneCards Identifiers for DNMT1 Gene

  • GC19M010365
  • GC19M010466
  • GC19M010089
  • GC19M010105
  • GC19M010244
  • GC19M009824

Summaries for DNMT1 Gene

Entrez Gene Summary for DNMT1 Gene

  • This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for DNMT1 Gene

DNMT1 (DNA (Cytosine-5-)-Methyltransferase 1) is a Protein Coding gene. Diseases associated with DNMT1 include cerebellar ataxia, deafness, and narcolepsy, autosomal dominant and neuropathy, hereditary sensory, type ie. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include RNA binding and transcription factor binding.

UniProtKB/Swiss-Prot for DNMT1 Gene

  • Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionnally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306).

Tocris Summary for DNMT1 Gene

  • Protein arginine methyltransferases are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the arginine residues on histones and other proteins. The dysregulation of this methylation is critical in the development of certain cancers.

Gene Wiki entry for DNMT1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNMT1 Gene

Genomics for DNMT1 Gene

Regulatory Elements for DNMT1 Gene

Promoters for DNMT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DNMT1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the DNMT1 gene promoter:

Genomic Location for DNMT1 Gene

Chromosome:
19
Start:
10,133,345 bp from pter
End:
10,231,286 bp from pter
Size:
97,942 bases
Orientation:
Minus strand

Genomic View for DNMT1 Gene

Genes around DNMT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNMT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNMT1 Gene

Proteins for DNMT1 Gene

  • Protein details for DNMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26358-DNMT1_HUMAN
    Recommended name:
    DNA (cytosine-5)-methyltransferase 1
    Protein Accession:
    P26358
    Secondary Accessions:
    • A0AV63
    • B7ZLW6
    • Q9UHG5
    • Q9ULA2
    • Q9UMZ6

    Protein attributes for DNMT1 Gene

    Size:
    1616 amino acids
    Molecular mass:
    183165 Da
    Quaternary structure:
    • Homodimer (PubMed:19173286). Forms a stable complex with E2F1, BB1 and HDAC1 (PubMed:10888886). Forms a complex with DMAP1 and HDAC2, with direct interaction (PubMed:10888872). Interacts with the PRC2/EED-EZH2 complex (PubMed:16357870). Probably part of a corepressor complex containing ZNF304, TRIM28, SETDB1 and DNMT1 (PubMed:24623306). Interacts with UHRF1; promoting its recruitment to hemimethylated DNA (PubMed:21745816). Interacts with USP7, promoting its deubiquitination (PubMed:21745816). Interacts with PCNA (PubMed:9302295). Interacts with MBD2 and MBD3 (PubMed:10947852). Interacts with DNMT3A and DNMT3B (PubMed:12145218). Interacts with UBC9 (PubMed:19450230). Interacts with CSNK1D (By similarity). Interacts with HDAC1 (By similarity). Interacts with BAZ2A/TIP5 (By similarity).
    SequenceCaution:
    • Sequence=AAD54507.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DNMT1 Gene

    Alternative splice isoforms for DNMT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNMT1 Gene

Proteomics data for DNMT1 Gene at MOPED

Post-translational modifications for DNMT1 Gene

  • Acetylation on multiple lysines, mainly by KAT2B/PCAF, regulates cell cycle G(2)/M transition. Deacetylation of Lys-1349 and Lys-1415 by SIRT1 increases methyltransferase activity.
  • Methylation at Lys-142 by SETD7 promotes DNMT1 proteasomal degradation.
  • Phosphorylation of Ser-154 by CDKs is important for enzymatic activity and protein stability. Phosphorylation of Ser-143 by AKT1 prevents methylation by SETD7 therebye increasing DNMT1 stability.
  • Sumoylated; sumoylation increases activity.
  • Ubiquitinated by UHRF1; interaction with USP7 counteracts ubiquitination by UHRF1 by promoting deubiquitination and preventing degradation by the proteasome.
  • Ubiquitination at Lys 58, Lys 88, Lys 134, Lys 586, Lys 666, Lys 928, Lys 961, Lys 981, Lys 997, Lys 1323, Lys 1415, Lys 1483, and Lys 1572
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DNMT1 (DNMT1)

Domains & Families for DNMT1 Gene

Gene Families for DNMT1 Gene

Suggested Antigen Peptide Sequences for DNMT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P26358

UniProtKB/Swiss-Prot:

DNMT1_HUMAN :
  • The N-terminal part is required for homodimerization and acts as a regulatory domain.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
  • Contains 1 CXXC-type zinc finger.
Domain:
  • The N-terminal part is required for homodimerization and acts as a regulatory domain.
  • The CXXC-type zinc finger specifically binds to unmethylated CpG dinucleotides, positioning the autoinhibitory linker between the DNA and the active site, thus providing a mechanism to ensure that only hemimethylated CpG dinucleotides undergo methylation.
  • Contains 2 BAH domains.
  • Contains 1 DMAP-interaction domain.
  • Contains 1 SAM-dependent MTase C5-type domain.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
Similarity:
  • Contains 1 CXXC-type zinc finger.
genes like me logo Genes that share domains with DNMT1: view

Function for DNMT1 Gene

Molecular function for DNMT1 Gene

GENATLAS Biochemistry:
DNA methyltransferase,1 (5-methyl-cytosine),constitutively expressed, with two alternatively spliced isoforms,a long form abundantly expressed in several tissues and cell lines and a short form,mainly involved in the maintenance of DNA-methylation activities,also associating with HDAC1,acting as a putative mediator of the methylation process
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.
UniProtKB/Swiss-Prot Function:
Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionnally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306).
UniProtKB/Swiss-Prot Induction:
Its abundance is reduced to non detectable levels at the G0 phase of the cell cycle and is dramatically induced upon entrance into the S-phase of the cell cycle.

Enzyme Numbers (IUBMB) for DNMT1 Gene

Gene Ontology (GO) - Molecular Function for DNMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008134 transcription factor binding IEA --
GO:0008168 methyltransferase activity IEA --
GO:0009008 DNA-methyltransferase activity TAS --
GO:0030331 estrogen receptor binding IEA --
GO:0045322 unmethylated CpG binding IEA --
genes like me logo Genes that share ontologies with DNMT1: view
genes like me logo Genes that share phenotypes with DNMT1: view

Human Phenotype Ontology for DNMT1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DNMT1 Gene

MGI Knock Outs for DNMT1:

Animal Model Products

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for DNMT1 Gene

Localization for DNMT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNMT1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNMT1 Gene COMPARTMENTS Subcellular localization image for DNMT1 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for DNMT1 Gene

Pathways & Interactions for DNMT1 Gene

genes like me logo Genes that share pathways with DNMT1: view

SIGNOR curated interactions for DNMT1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DNMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0007265 Ras protein signal transduction IMP 24623306
GO:0007568 aging IEA --
GO:0009636 response to toxic substance IEA --
GO:0010033 response to organic substance IEA --
genes like me logo Genes that share ontologies with DNMT1: view

Drugs & Compounds for DNMT1 Gene

(54) Drugs for DNMT1 Gene - From: Novoseek, ApexBio, Tocris, DGIdb, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Decitabine Approved, Investigational Pharma inhibitor, Target DNA methyltransferase inhibitor 208
Azacitidine Approved, Investigational Pharma inhibitor, Target 360
Procainamide Approved Pharma Target, other 12
Flucytosine Approved Pharma Target, other 24
S-Adenosylmethionine Approved Nutra 0

(51) Additional Compounds for DNMT1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DNMT1: view

Drug Products

Transcripts for DNMT1 Gene

Unigene Clusters for DNMT1 Gene

DNA (cytosine-5-)-methyltransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNMT1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18 ^
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:

ExUns: 19a · 19b ^ 20 ^ 21a · 21b ^ 22a · 22b · 22c ^ 23 ^ 24 ^ 25 ^ 26a · 26b · 26c · 26d ^ 27a · 27b · 27c ^ 28a · 28b · 28c ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^
SP1: - - - - -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7: - - - - - -
SP8:
SP9:
SP10:
SP11:
SP12: - -
SP13: - - - -
SP14: - - - -
SP15:
SP16:
SP17: - -
SP18: - -
SP19:
SP20:
SP21:
SP22:
SP23:

ExUns: 33a · 33b · 33c · 33d ^ 34 ^ 35a · 35b ^ 36 ^ 37 ^ 38
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - -
SP17:
SP18:
SP19:
SP20: -
SP21:
SP22:
SP23: - - -

Relevant External Links for DNMT1 Gene

GeneLoc Exon Structure for
DNMT1
ECgene alternative splicing isoforms for
DNMT1

Expression for DNMT1 Gene

mRNA expression in normal human tissues for DNMT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNMT1 Gene

This gene is overexpressed in Nasal epithelium (10.3), Bone marrow mesenchymal stem cell (8.4), Lymph node (7.6), and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNMT1 Gene



SOURCE GeneReport for Unigene cluster for DNMT1 Gene Hs.202672

mRNA Expression by UniProt/SwissProt for DNMT1 Gene

P26358-DNMT1_HUMAN
Tissue specificity: Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform 1.
genes like me logo Genes that share expression patterns with DNMT1: view

Protein tissue co-expression partners for DNMT1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DNMT1 Gene

Orthologs for DNMT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNMT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNMT1 36
  • 100 (a)
OneToOne
DNMT1 35
  • 99.37 (n)
  • 99.94 (a)
cow
(Bos Taurus)
Mammalia DNMT1 36
  • 89 (a)
OneToOne
DNMT1 35
  • 86.55 (n)
  • 89.57 (a)
dog
(Canis familiaris)
Mammalia DNMT1 35
  • 87.56 (n)
  • 91.56 (a)
DNMT1 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnmt1 36
  • 77 (a)
OneToOne
Dnmt1 16
Dnmt1 35
  • 78.77 (n)
  • 78.69 (a)
oppossum
(Monodelphis domestica)
Mammalia DNMT1 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dnmt1 35
  • 79.13 (n)
  • 79.59 (a)
chicken
(Gallus gallus)
Aves DNMT1 35
  • 75.16 (n)
  • 78.91 (a)
DNMT1 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNMT1 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnmt1 35
  • 70.64 (n)
  • 75.53 (a)
Str.1757 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1220 35
zebrafish
(Danio rerio)
Actinopterygii dnmt1 35
  • 68.1 (n)
  • 72.4 (a)
dnmt1 36
  • 70 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons MET1 35
  • 47.82 (n)
  • 42.82 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.11558 35
corn
(Zea mays)
Liliopsida Zm.16993 35
rice
(Oryza sativa)
Liliopsida Os.30977 35
Os03g0798300 35
  • 57.91 (n)
  • 56.38 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.9261 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12055 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToOne
Species with no ortholog for DNMT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for DNMT1 Gene

ENSEMBL:
Gene Tree for DNMT1 (if available)
TreeFam:
Gene Tree for DNMT1 (if available)

Paralogs for DNMT1 Gene

genes like me logo Genes that share paralogs with DNMT1: view

No data available for Paralogs for DNMT1 Gene

Variants for DNMT1 Gene

Sequence variations from dbSNP and Humsavar for DNMT1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs16999593 - 10,180,505(+) AAGCA(C/T)GAGCA reference, missense, utr-variant-5-prime
rs2228612 - 10,162,696(-) CACAG(A/C/G/T)TTTCT reference, missense
VAR_065966 Neuropathy, hereditary sensory, 1E (HSN1E)
VAR_070055 Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant (ADCADN)
VAR_070056 Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant (ADCADN)

Structural Variations from Database of Genomic Variants (DGV) for DNMT1 Gene

Variant ID Type Subtype PubMed ID
nsv833743 CNV Loss 17160897
esv1001261 CNV Deletion 20482838
esv2718168 CNV Deletion 23290073

Variation tolerance for DNMT1 Gene

Residual Variation Intolerance Score: 0.97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNMT1 Gene

HapMap Linkage Disequilibrium report
DNMT1
Human Gene Mutation Database (HGMD)
DNMT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNMT1 Gene

Disorders for DNMT1 Gene

MalaCards: The human disease database

(22) MalaCards diseases for DNMT1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cerebellar ataxia, deafness, and narcolepsy, autosomal dominant
  • autosomal dominant cerebellar ataxia, deafness and narcolepsy
neuropathy, hereditary sensory, type ie
  • hereditary sensory neuropathy type ie
narcolepsy
  • narcolepsy, without cataplexy
cerebellar ataxia
  • hemosiderosis, systemic, due to aceruloplasminemia
lichtenstein-knorr syndrome
  • autosomal recessive spinocerebellar ataxia 19
- elite association - COSMIC cancer census association via MalaCards
Search DNMT1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DNMT1_HUMAN
  • Neuropathy, hereditary sensory, 1E (HSN1E) [MIM:614116]: A neurodegenerative disorder characterized by adult onset of progressive peripheral sensory loss associated with progressive hearing impairment and early-onset dementia. {ECO:0000269 PubMed:21532572}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant (ADCADN) [MIM:604121]: An autosomal dominant neurologic disorder characterized by adult onset of progressive cerebellar ataxia, narcolepsy, cataplexy, sensorineural deafness, and dementia. More variable features include optic atrophy, sensory neuropathy, psychosis, and depression. {ECO:0000269 PubMed:22328086}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for DNMT1

Genetic Association Database (GAD)
DNMT1
Human Genome Epidemiology (HuGE) Navigator
DNMT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNMT1
genes like me logo Genes that share disorders with DNMT1: view

No data available for Genatlas for DNMT1 Gene

Publications for DNMT1 Gene

  1. Isolation and characterization of the cDNA encoding human DNA methyltransferase. (PMID: 1594447) Yen R.-W.C. … Baylin S.B. (Nucleic Acids Res. 1992) 2 3 4 67
  2. A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines. (PMID: 20126405) Hollenbach P.W. … MacBeth K.J. (PLoS ONE 2010) 23 25 26
  3. Azacitidine for the treatment of myelodysplastic syndrome. (PMID: 19589026) Cataldo V.D. … QuintA!s-Cardama A. (Expert Rev Anticancer Ther 2009) 23 25 26
  4. DNA methyltransferases as targets for cancer therapy. (PMID: 17612710) Ghoshal K. … Bai S. (Drugs Today 2007) 23 25 26
  5. Effect of 5-azacytidine and procainamide on CD3-zeta chain expression in Jurkat T cells. (PMID: 15795105) Januchowski R. … Jagodzinski P.P. (Biomed. Pharmacother. 2005) 23 25 26

Products for DNMT1 Gene

  • Addgene plasmids for DNMT1

Sources for DNMT1 Gene

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