Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DNMT1 Gene

Aliases for DNMT1 Gene

  • DNA (Cytosine-5-)-Methyltransferase 1 2 3
  • MCMT 3 4 6
  • CXXC-Type Zinc Finger Protein 9 3 4
  • DNA Methyltransferase HsaI 3 4
  • DNA MTase HsaI 3 4
  • EC 2.1.1.37 4 63
  • M.HsaI 3 4
  • ADCADN 3 6
  • HSN1E 3 6
  • CXXC9 3 4
  • DNMT 3 4
  • AIM 3 4
  • DNA (Cytosine-5)-Methyltransferase 1 3
  • Dnmt1 4

External Ids for DNMT1 Gene

Previous HGNC Symbols for DNMT1 Gene

  • DNMT

Previous GeneCards Identifiers for DNMT1 Gene

  • GC19M010365
  • GC19M010466
  • GC19M010089
  • GC19M010105
  • GC19M010244
  • GC19M009824

Summaries for DNMT1 Gene

Entrez Gene Summary for DNMT1 Gene

  • DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for DNMT1 Gene

DNMT1 (DNA (Cytosine-5-)-Methyltransferase 1) is a Protein Coding gene. Diseases associated with DNMT1 include neuropathy, hereditary sensory, type ie and cerebellar ataxia, deafness, and narcolepsy, autosomal dominant. Among its related pathways are MicroRNAs in cancer and Metabolism. GO annotations related to this gene include RNA binding and methyl-CpG binding.

UniProtKB/Swiss-Prot for DNMT1 Gene

  • Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.

Tocris Summary for DNMT1 Gene

  • DNA methyltransferase (DNMT) add methyl groups to DNA to effect gene expression. There are three types of DNMTs. DNMT1 is predominately responsible for hemimethylated CpG island methylation, DNMT2 in fact transfers methyl groups to RNA not DNA, hence has been renamed to tRNA aspartic acid methyltransferase 1 (TRDMT1) and DNMT3 is responsible for unmethylated CpG island methylation.

Gene Wiki entry for DNMT1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNMT1 Gene

Genomics for DNMT1 Gene

Regulatory Elements for DNMT1 Gene

Transcription factor binding sites by QIAGEN in the DNMT1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DNMT1 Gene

Start:
10,133,345 bp from pter
End:
10,231,286 bp from pter
Size:
97,942 bases
Orientation:
Minus strand

Genomic View for DNMT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNMT1 Gene

Proteins for DNMT1 Gene

  • Protein details for DNMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26358-DNMT1_HUMAN
    Recommended name:
    DNA (cytosine-5)-methyltransferase 1
    Protein Accession:
    P26358
    Secondary Accessions:
    • A0AV63
    • B7ZLW6
    • Q9UHG5
    • Q9ULA2
    • Q9UMZ6

    Protein attributes for DNMT1 Gene

    Size:
    1616 amino acids
    Molecular mass:
    183165 Da
    Quaternary structure:
    • Binds to CSNK1D (By similarity). Homodimer. Interacts with HDAC1 and with PCNA. Forms a complex with DMAP1 and HDAC2, with direct interaction. Forms also a stable complex with E2F1, BB1 and HDAC1. Binds MBD2 and MBD3. Component of complexes containing SUV39H1. Interacts with DNMT3A and DNMT3B. Interacts with the PRC2/EED-EZH2 complex. Interacts with UBC9 and BAZ2A/TIP5. Interacts with UHRF1; promoting its recruitment to hemimethylated DNA. Interacts with USP7, promoting its deubiquitination.
    SequenceCaution:
    • Sequence=AAD54507.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DNMT1 Gene

    Alternative splice isoforms for DNMT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNMT1 Gene

Proteomics data for DNMT1 Gene at MOPED

Post-translational modifications for DNMT1 Gene

  • Acetylation on multiple lysines, mainly by KAT2B/PCAF, regulates cell cycle G(2)/M transition. Deacetylation of Lys-1349 and Lys-1415 by SIRT1 increases methyltransferase activity.
  • Methylation at Lys-142 by SETD7 promotes DNMT1 proteasomal degradation.
  • Phosphorylation of Ser-154 by CDKs is important for enzymatic activity and protein stability. Phosphorylation of Ser-143 by AKT1 prevents methylation by SETD7 therebye increasing DNMT1 stability.
  • Sumoylated; sumoylation increases activity.
  • Ubiquitinated by UHRF1; interaction with USP7 counteracts ubiquitination by UHRF1 by promoting deubiquitination and preventing degradation by the proteasome.
  • Ubiquitination at Lys58, Lys88, Lys134, Lys586, Lys666, Lys928, Lys961, Lys981, Lys997, Lys1323, Lys1415, Lys1483, and Lys1572
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DNMT1 (DNMT1)

Domains for DNMT1 Gene

Suggested Antigen Peptide Sequences for DNMT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P26358

UniProtKB/Swiss-Prot:

DNMT1_HUMAN :
  • P26358
Domain:
  • The N-terminal part is required for homodimerization and acts as a regulatory domain
  • The CXXC-type zinc finger specifically binds to unmethylated CpG dinucleotides, positioning the autoinhibitory linker between the DNA and the active site, thus providing a mechanism to ensure that only hemimethylated CpG dinucleotides undergo methylation.
  • Contains 2 BAH domains.
  • Contains 1 DMAP-interaction domain.
  • Contains 1 SAM-dependent MTase C5-type domain.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
Similarity:
  • Contains 1 CXXC-type zinc finger.
genes like me logo Genes that share domains with DNMT1: view

No data available for Gene Families for DNMT1 Gene

Function for DNMT1 Gene

Molecular function for DNMT1 Gene

GENATLAS Biochemistry: DNA methyltransferase,1 (5-methyl-cytosine),constitutively expressed, with two alternatively spliced isoforms,a long form abundantly expressed in several tissues and cell lines and a short form,mainly involved in the maintenance of DNA-methylation activities,also associating with HDAC1,acting as a putative mediator of the methylation process
UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.
UniProtKB/Swiss-Prot Function: Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.
UniProtKB/Swiss-Prot Induction: Its abundance is reduced to non detectable levels at the G0 phase of the cell cycle and is dramatically induced upon entrance into the S-phase of the cell cycle

Enzyme Numbers (IUBMB) for DNMT1 Gene

Gene Ontology (GO) - Molecular Function for DNMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 18754681
GO:0003682 chromatin binding IEA --
GO:0003723 RNA binding IEA --
GO:0003886 DNA (cytosine-5-)-methyltransferase activity IDA 21745816
GO:0005515 protein binding IPI 16357870
genes like me logo Genes that share ontologies with DNMT1: view
genes like me logo Genes that share phenotypes with DNMT1: view

Animal Models for DNMT1 Gene

MGI Knock Outs for DNMT1:

Animal Model Products

CRISPR Products

No data available for Transcription Factor Targeting and HOMER Transcription for DNMT1 Gene

Localization for DNMT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNMT1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNMT1 Gene COMPARTMENTS Subcellular localization image for DNMT1 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for DNMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000792 heterochromatin --
GO:0005634 nucleus IDA 16791210
GO:0005654 nucleoplasm TAS --
GO:0005657 replication fork IEA --
GO:0005721 pericentric heterochromatin IEA --
genes like me logo Genes that share ontologies with DNMT1: view

Pathways for DNMT1 Gene

genes like me logo Genes that share pathways with DNMT1: view

Pathways by source for DNMT1 Gene

1 GeneGo (Thomson Reuters) pathway for DNMT1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DNMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006306 DNA methylation TAS 10888872
GO:0006351 transcription, DNA-templated IEA --
GO:0010216 maintenance of DNA methylation IDA 18754681
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with DNMT1: view

Compounds for DNMT1 Gene

Compound Products

(5) Tocris Compounds for DNMT1 Gene

Compound Action Cas Number
5-Azacytidine DNA methyltransferase inhibitor [320-67-2]
5-Iodotubercidin Potent adenosine kinase inhibitor; also inhibits nucleoside transporters and a range of other kinases [24386-93-4]
Decitabine DNA methyltransferase inhibitor [2353-33-5]
Lomeguatrib MGMT inhibitor [192441-08-0]
Zebularine DNA methyltransferase and cytidine deaminase inhibitor [3690-10-6]

(9) ApexBio Compounds for DNMT1 Gene

Compound Action Cas Number
5-Azacytidine DNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. [320-67-2]
Decitabine (NSC127716, 5AZA-CdR) Decitabine is a kind of deoxycytidine analog and an inducer of cellular differentiation. [2353-33-5]
Lomeguatrib Inhibitor of O6-methylguanine-DNA methyltransferase (MGMT); (IC50 = 0.009 uM in cell-free extracts from HeLa S3 cells); [192441-08-0]
Nanaomycin A Selective DNMT3B inhibitor, regulates DNA methylation. [52934-83-5]
Nanaomycin C amide of nanaomycin A [58286-55-8]
RG 108 RG108 is a DNA methyltransferase (DMNT) inhibitor that enhanced reprogramming of OK-transduced MEFs in the presence of BIX. [48208-26-0]
SGI-110 SGI-110 is a second generation DNA-hypomethyating agent. [929901-49-5]
Thioguanine Thioguanine is a purine antimetabolite widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohns disease, rheumatoid arthritis) and organ transplant recipients. [154-42-7]
Zebularine Zebularine, a chemically stable cytidine analog containing a 2-(1H)-pyridimidinone ring, is an effective DNA methylation inhibitor which can act with DNA methyltransferases to form a covalent complex. It has been shown to cause demethylation and reactivat [3690-10-6]

(3) HMDB Compounds for DNMT1 Gene

Compound Synonyms Cas Number PubMed IDs
5-Methylcytosine
  • 4-Amino-5-methyl-2-pyrimidinol
554-01-8
S-Adenosylhomocysteine
  • (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine
979-92-0
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0

(4) Drugbank Compounds for DNMT1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Azacitidine
  • 5 AZC
320-67-2 target inhibitor
Decitabine
  • 5-aza-2'-deoxycytidine
2353-33-5 target inhibitor
Flucytosine
  • 5-FC
2022-85-7 target other
Procainamide
51-06-9 target other

(96) Novoseek inferred chemical compound relationships for DNMT1 Gene

Compound -log(P) Hits PubMed IDs
5-aza-2deoxycytidine 95.7 122
zebularine 88.6 15
cytosine 86.6 62
5-methylcytosine 83.6 17
s-adenosylmethionine 80.1 41
genes like me logo Genes that share compounds with DNMT1: view

Transcripts for DNMT1 Gene

Unigene Clusters for DNMT1 Gene

DNA (cytosine-5-)-methyltransferase 1:
Representative Sequences:

CRISPR Products

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DNMT1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNMT1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18 ^
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:

ExUns: 19a · 19b ^ 20 ^ 21a · 21b ^ 22a · 22b · 22c ^ 23 ^ 24 ^ 25 ^ 26a · 26b · 26c · 26d ^ 27a · 27b · 27c ^ 28a · 28b · 28c ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^
SP1: - - - - -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7: - - - - - -
SP8:
SP9:
SP10:
SP11:
SP12: - -
SP13: - - - -
SP14: - - - -
SP15:
SP16:
SP17: - -
SP18: - -
SP19:
SP20:
SP21:
SP22:
SP23:

ExUns: 33a · 33b · 33c · 33d ^ 34 ^ 35a · 35b ^ 36 ^ 37 ^ 38
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - -
SP17:
SP18:
SP19:
SP20: -
SP21:
SP22:
SP23: - - -

Relevant External Links for DNMT1 Gene

GeneLoc Exon Structure for
DNMT1
ECgene alternative splicing isoforms for
DNMT1

Expression for DNMT1 Gene

mRNA expression in normal human tissues for DNMT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNMT1 Gene

SOURCE GeneReport for Unigene cluster for DNMT1 Gene Hs.202672

mRNA Expression by UniProt/SwissProt for DNMT1 Gene

P26358-DNMT1_HUMAN
Tissue specificity: Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform 1.
genes like me logo Genes that share expressions with DNMT1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DNMT1 Gene

Orthologs for DNMT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNMT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNMT1 35
  • 99.37 (n)
  • 99.94 (a)
DNMT1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNMT1 35
  • 86.55 (n)
  • 89.57 (a)
DNMT1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNMT1 35
  • 87.56 (n)
  • 91.56 (a)
DNMT1 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnmt1 35
  • 78.77 (n)
  • 78.69 (a)
Dnmt1 16
Dnmt1 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNMT1 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dnmt1 35
  • 79.13 (n)
  • 79.59 (a)
chicken
(Gallus gallus)
Aves DNMT1 35
  • 75.16 (n)
  • 78.91 (a)
DNMT1 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNMT1 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnmt1 35
  • 70.64 (n)
  • 75.53 (a)
Str.1757 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1220 35
zebrafish
(Danio rerio)
Actinopterygii dnmt1 35
  • 68.1 (n)
  • 72.4 (a)
dnmt1 36
  • 70 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons MET1 35
  • 47.82 (n)
  • 42.82 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.11558 35
corn
(Zea mays)
Liliopsida Zm.16993 35
rice
(Oryza sativa)
Liliopsida Os.30977 35
Os03g0798300 35
  • 57.91 (n)
  • 56.38 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.9261 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12055 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToOne
Species with no ortholog for DNMT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for DNMT1 Gene

ENSEMBL:
Gene Tree for DNMT1 (if available)
TreeFam:
Gene Tree for DNMT1 (if available)

Paralogs for DNMT1 Gene

genes like me logo Genes that share paralogs with DNMT1: view

No data available for Paralogs for DNMT1 Gene

Variants for DNMT1 Gene

Sequence variations from dbSNP and Humsavar for DNMT1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs11488 -- 10,133,368(-) TCTTC(A/T)AATAA utr-variant-3-prime
rs13784 -- 10,133,520(-) AGGTT(C/T)GCTTA utr-variant-3-prime
rs721186 -- 10,154,636(+) CAGGG(C/T)GTCAG reference, synonymous-codon
rs759920 -- 10,174,102(+) ACAAA(A/G)GCAGG intron-variant
rs919188 -- 10,141,614(+) CACCC(A/G)CACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNMT1 Gene

Variant ID Type Subtype PubMed ID
nsv833743 CNV Loss 17160897
esv1001261 CNV Deletion 20482838
esv2718168 CNV Deletion 23290073

Relevant External Links for DNMT1 Gene

HapMap Linkage Disequilibrium report
DNMT1
Human Gene Mutation Database (HGMD)
DNMT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNMT1 Gene

Disorders for DNMT1 Gene

(2) OMIM Diseases for DNMT1 Gene (126375)

UniProtKB/Swiss-Prot

DNMT1_HUMAN
  • Neuropathy, hereditary sensory, 1E (HSN1E) [MIM:614116]: A neurodegenerative disorder characterized by adult onset of progressive peripheral sensory loss associated with progressive hearing impairment and early-onset dementia. {ECO:0000269 PubMed:21532572}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant (ADCADN) [MIM:604121]: An autosomal dominant neurologic disorder characterized by adult onset of progressive cerebellar ataxia, narcolepsy, cataplexy, sensorineural deafness, and dementia. More variable features include optic atrophy, sensory neuropathy, psychosis, and depression. {ECO:0000269 PubMed:22328086}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for DNMT1 Gene

(89) Novoseek inferred disease relationships for DNMT1 Gene

Disease -log(P) Hits PubMed IDs
icf syndrome 79.7 3
myelodysplastic syndromes 70.8 17
cancer 70.4 149
tumors 61.8 133
leukemogenesis 50 3

Relevant External Links for DNMT1

Genetic Association Database (GAD)
DNMT1
Human Genome Epidemiology (HuGE) Navigator
DNMT1
genes like me logo Genes that share disorders with DNMT1: view

Publications for DNMT1 Gene

  1. The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. (PMID: 10325416) Robertson K.D. … Jones P.A. (Nucleic Acids Res. 1999) 3 4 23
  2. DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. (PMID: 10888886) Robertson K.D. … Wolffe A.P. (Nat. Genet. 2000) 3 4 23
  3. Characterization of the human DNA methyltransferase splice variant Dnmt1b. (PMID: 10753866) Bonfils C. … MacLeod A.R. (J. Biol. Chem. 2000) 3 4 23
  4. Association analyses of DNA methyltransferase-1 (DNMT1) polymorphisms with systemic lupus erythematosus. (PMID: 15375672) Park B.L. … Bae S.C. (J. Hum. Genet. 2004) 3 23 48
  5. CXXC domain of human DNMT1 is essential for enzymatic activity. (PMID: 18754681) Pradhan M. … Pradhan S. (Biochemistry 2008) 3 4 23

Products for DNMT1 Gene

  • Addgene plasmids for DNMT1

Sources for DNMT1 Gene

Back to Top

Content