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Aliases for DNMBP Gene

Aliases for DNMBP Gene

  • Dynamin Binding Protein 2 3 5
  • Scaffold Protein TUBA 2 3
  • Scaffold Protein Tuba 4
  • ARHGEF36 3
  • KIAA1010 4
  • TUBA 3

External Ids for DNMBP Gene

Previous GeneCards Identifiers for DNMBP Gene

  • GC10M101301
  • GC10M101625
  • GC10M095263

Summaries for DNMBP Gene

Entrez Gene Summary for DNMBP Gene

  • This gene encodes a protein belonging to the guanine nucleotide exchange factor family, and which regulates the configuration of cell junctions. It contains multiple binding sites for dynamin and thus links dynamin to actin regulatory proteins. Polymorphisms in this gene have been linked to Alzheimer's disease in some populations, though there are conflicting reports of such linkages in other populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for DNMBP Gene

DNMBP (Dynamin Binding Protein) is a Protein Coding gene. Diseases associated with DNMBP include Alzheimer Disease. Among its related pathways are Regulation of CDC42 activity. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF37.

UniProtKB/Swiss-Prot for DNMBP Gene

  • Scaffold protein that links dynamin with actin-regulating proteins. May play a role in membrane trafficking between the cell surface and the Golgi (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNMBP Gene

Genomics for DNMBP Gene

Regulatory Elements for DNMBP Gene

Enhancers for DNMBP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DNMBP on UCSC Golden Path with GeneCards custom track

Promoters for DNMBP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DNMBP on UCSC Golden Path with GeneCards custom track

Genomic Location for DNMBP Gene

99,875,576 bp from pter
100,009,948 bp from pter
134,373 bases
Minus strand

Genomic View for DNMBP Gene

Genes around DNMBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNMBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNMBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNMBP Gene

Proteins for DNMBP Gene

  • Protein details for DNMBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dynamin-binding protein
    Protein Accession:
    Secondary Accessions:
    • Q8IVY3
    • Q9Y2L3

    Protein attributes for DNMBP Gene

    1577 amino acids
    Molecular mass:
    177347 Da
    Quaternary structure:
    • Binds DNM1 via its N-terminal SH3 domains. The C-terminal SH3 domain binds a complex containing actin, tubulin, Hsp70 and actin-regulatory proteins, such as ENAH, EVL, WASL, WIRE, CR16, WAVE1 and NAP1L1 (By similarity). Interacts with FASLG.

    Three dimensional structures from OCA and Proteopedia for DNMBP Gene

    Alternative splice isoforms for DNMBP Gene


neXtProt entry for DNMBP Gene

Proteomics data for DNMBP Gene at MOPED

Post-translational modifications for DNMBP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNMBP Gene

No data available for DME Specific Peptides for DNMBP Gene

Domains & Families for DNMBP Gene

Gene Families for DNMBP Gene

Protein Domains for DNMBP Gene

Suggested Antigen Peptide Sequences for DNMBP Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BAR domain.
  • Contains 1 BAR domain.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 6 SH3 domains.
genes like me logo Genes that share domains with DNMBP: view

Function for DNMBP Gene

Molecular function for DNMBP Gene

UniProtKB/Swiss-Prot Function:
Scaffold protein that links dynamin with actin-regulating proteins. May play a role in membrane trafficking between the cell surface and the Golgi (By similarity).
genes like me logo Genes that share phenotypes with DNMBP: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNMBP Gene

Localization for DNMBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNMBP Gene

Cytoplasm. Golgi apparatus, Golgi stack. Cytoplasm, cytoskeleton. Cell junction, synapse. Note=Localized to synapses and Golgi stacks. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for DNMBP Gene COMPARTMENTS Subcellular localization image for DNMBP gene
Compartment Confidence
cytoskeleton 3
cytosol 3
golgi apparatus 3
nucleus 3

Gene Ontology (GO) - Cellular Components for DNMBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005795 Golgi stack IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with DNMBP: view

Pathways & Interactions for DNMBP Gene

SuperPathways for DNMBP Gene

genes like me logo Genes that share pathways with DNMBP: view

Pathways by source for DNMBP Gene

1 BioSystems pathway for DNMBP Gene

Gene Ontology (GO) - Biological Process for DNMBP Gene


No data available for SIGNOR curated interactions for DNMBP Gene

Drugs & Compounds for DNMBP Gene

No Compound Related Data Available

Transcripts for DNMBP Gene

Unigene Clusters for DNMBP Gene

Dynamin binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNMBP Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12
SP3: - - -
SP4: -

Relevant External Links for DNMBP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNMBP Gene

mRNA expression in normal human tissues for DNMBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNMBP Gene

This gene is overexpressed in Cervix (46.1) and Breast (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNMBP Gene

SOURCE GeneReport for Unigene cluster for DNMBP Gene Hs.500771

mRNA Expression by UniProt/SwissProt for DNMBP Gene

Tissue specificity: Detected in heart, brain, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with DNMBP: view

Protein tissue co-expression partners for DNMBP Gene

Primer Products

No data available for mRNA differential expression in normal tissues for DNMBP Gene

Orthologs for DNMBP Gene

This gene was present in the common ancestor of animals.

Orthologs for DNMBP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DNMBP 35
  • 85.37 (n)
  • 85.11 (a)
  • 85 (a)
(Canis familiaris)
Mammalia DNMBP 35
  • 85.11 (n)
  • 83.55 (a)
  • 83 (a)
(Mus musculus)
Mammalia Dnmbp 35
  • 78.85 (n)
  • 77.08 (a)
Dnmbp 16
Dnmbp 36
  • 76 (a)
(Rattus norvegicus)
Mammalia Dnmbp 35
  • 78.64 (n)
  • 76.02 (a)
(Monodelphis domestica)
Mammalia DNMBP 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
-- 36
  • 71 (a)
(Gallus gallus)
Aves DNMBP 35
  • 67.32 (n)
  • 66.15 (a)
  • 64 (a)
(Anolis carolinensis)
Reptilia DNMBP 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnmbp 35
  • 61.06 (n)
  • 59.55 (a)
Str.13042 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.19408 35
(Danio rerio)
Actinopterygii dnmbp 35
  • 58.43 (n)
  • 55.35 (a)
dnmbp 36
  • 49 (a)
(Caenorhabditis elegans)
Secernentea Y37A1B.17 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for DNMBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNMBP Gene

Gene Tree for DNMBP (if available)
Gene Tree for DNMBP (if available)

Paralogs for DNMBP Gene

Paralogs for DNMBP Gene

(4) SIMAP similar genes for DNMBP Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DNMBP: view

Variants for DNMBP Gene

Sequence variations from dbSNP and Humsavar for DNMBP Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs11190305 - 99,880,120(+) TGGTC(A/C/G)CATTC reference, missense
rs12267912 - 99,969,140(+) TCCAA(A/C)TCTTG reference, missense
VAR_050956 -
rs7919507 - 99,898,264(+) CCCAG(C/G)TTAAT reference, missense
rs7652 -- 99,875,704(-) GTCCT(A/T)ACATC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DNMBP Gene

Variant ID Type Subtype PubMed ID
nsv825539 CNV Loss 20364138
nsv825540 CNV Gain 20364138
nsv831960 CNV Gain 17160897
nsv7517 CNV Insertion 18451855
esv2678240 CNV Deletion 23128226
nsv7518 CNV Loss 18451855
nsv507574 CNV Insertion 20534489
nsv516789 CNV Loss 19592680

Variation tolerance for DNMBP Gene

Residual Variation Intolerance Score: 15.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.56; 77.94% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DNMBP Gene

Disorders for DNMBP Gene

MalaCards: The human disease database

(1) MalaCards diseases for DNMBP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • alzheimer disease, late-onset
- elite association - COSMIC cancer census association via MalaCards
Search DNMBP in MalaCards View complete list of genes associated with diseases

Relevant External Links for DNMBP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DNMBP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNMBP Gene

Publications for DNMBP Gene

  1. Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton. (PMID: 14506234) Salazar M.A. … De Camilli P. (J. Biol. Chem. 2003) 2 3 4 67
  2. DNMBP is genetically associated with Alzheimer dementia in the Belgian population. (PMID: 18359537) Bettens K. … Van Broeckhoven C. (Neurobiol. Aging 2009) 3 23
  3. Association analysis of dynamin-binding protein (DNMBP) on chromosome 10q with late onset Alzheimer's disease in a large caucasian UK sample. (PMID: 18452187) Morgan A.R. … Williams J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 23
  4. No association of dynamin binding protein (DNMBP) gene SNPs and Alzheimer's disease. (PMID: 17442457) Minster R.L. … Kamboh M.I. (Neurobiol. Aging 2008) 3 23
  5. [Genetic risk factor of Alzheimer's disease]. (PMID: 18210832) Kuwano R. (Rinsho Shinkeigaku 2007) 3 23

Products for DNMBP Gene

Sources for DNMBP Gene