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DNMBP Gene

protein-coding   GIFtS: 60
GCID: GC10M101625

Dynamin Binding Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dynamin Binding Protein1 2
Scaffold Protein Tuba1 2 3
TUBA2 5
KIAA10103 5
ARHGEF362
Dynamin-Binding Protein2

External Ids:    HGNC: 303731   Entrez Gene: 232682   Ensembl: ENSG000001075547   OMIM: 6112825   UniProtKB: Q6XZF73   

Export aliases for DNMBP gene to outside databases

Previous GC identifers: GC10M101301 GC10M095263


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNMBP Gene:
DNMBP belongs to the DBL (MIM 311030) family of guanine nucleotide exchange factors and plays a role in the
regulation of cell junctions (Otani et al., 2006 (PubMed 17015620)).(supplied by OMIM, Mar 2008)

GeneCards Summary for DNMBP Gene:
DNMBP (dynamin binding protein) is a protein-coding gene. Diseases associated with DNMBP include dementia, and alzheimer's disease. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF38.

UniProtKB/Swiss-Prot: DNMBP_HUMAN, Q6XZF7
Function: Scaffold protein that links dynamin with actin-regulating proteins. May play a role in membrane
trafficking between the cell surface and the Golgi (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNMBP gene promoter:
         GR   C/EBPbeta   Sp1   AML1a   GR-beta   CUTL1   C/EBPalpha   FOXO4   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNMBP promoter sequence
   Search Chromatin IP Primers for DNMBP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNMBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.2   Ensembl cytogenetic band:  10q24.2   HGNC cytogenetic band: 10q24.31

DNMBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNMBP gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M101625:  view genomic region     (about GC identifiers)

Start:
101,635,334 bp from pter      End:
101,769,676 bp from pter
Size:
134,343 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DNMBP_HUMAN, Q6XZF7 (See protein sequence)
Recommended Name: Dynamin-binding protein  
Size: 1577 amino acids; 177347 Da
Subunit: Binds DNM1 via its N-terminal SH3 domains. The C-terminal SH3 domain binds a complex containing actin,
tubulin, Hsp70 and actin-regulatory proteins, such as ENAH, EVL, WASL, WIRE, CR16, WAVE1 and NAP1L1 (By
similarity). Interacts with FASLG
Selected PDB 3D structures from and Proteopedia for DNMBP (see all 7):
1UG1 (3D)        1UHC (3D)        4CC2 (3D)        4CC3 (3D)        4CC4 (3D)        4CC7 (3D)    
Secondary accessions: Q8IVY3 Q9Y2L3
Alternative splicing: 2 isoforms:  Q6XZF7-1   Q6XZF7-2   

Explore the universe of human proteins at neXtProt for DNMBP: NX_Q6XZF7

Explore proteomics data for DNMBP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DNMBP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056036.1  
    ENSEMBL proteins: 
     ENSP00000315659   ENSP00000409476   ENSP00000344914   ENSP00000443657   ENSP00000443573  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARHGEF: Rho guanine nucleotide exchange factors

    Selected InterPro protein domains (see all 6):
     IPR011511 SH3_2
     IPR027267 AH/BAR-dom
     IPR001331 GDS_CDC24_CS
     IPR000219 DH-domain
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q6XZF7

    ProtoNet protein and cluster: Q6XZF7

    2 Blocks protein domains:
    IPB000219 DH domain
    IPB001452 SH3 domain signature


    UniProtKB/Swiss-Prot: DNMBP_HUMAN, Q6XZF7
    Similarity: Contains 1 BAR domain
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 6 SH3 domains


    DNMBP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DNMBP_HUMAN, Q6XZF7
    Function: Scaffold protein that links dynamin with actin-regulating proteins. May play a role in membrane
    trafficking between the cell surface and the Golgi (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005515protein binding IPI16413298
         
    DNMBP for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DNMBP:
     Increased cell number in G1, s  Upregulation of Wnt/beta-caten 

    Animal Models:
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    miRTarBase miRNAs that target DNMBP:
    hsa-let-7b-5p (MIRT052230), hsa-mir-26b-5p (MIRT028856), hsa-mir-17-5p (MIRT050939), hsa-mir-23b-3p (MIRT046341), hsa-mir-766-3p (MIRT039020), hsa-mir-124-3p (MIRT022215), hsa-mir-335-5p (MIRT016851)

    Block miRNA regulation of human, mouse, rat DNMBP using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate DNMBP:
    hsa-miR-3163 hsa-miR-3140-3p hsa-miR-3675-3p hsa-miR-1237 hsa-miR-340 hsa-miR-606 hsa-miR-3918
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DNMBP_HUMAN, Q6XZF7: Cytoplasm (By similarity). Golgi apparatus, Golgi stack (By similarity). Cytoplasm,
    cytoskeleton (By similarity). Cell junction, synapse (By similarity). Note=Localized to synapses and Golgi stacks
    (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    cytoskeleton2
    golgi apparatus2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005795Golgi stack IEA--
    GO:0005856cytoskeleton IEA--
    GO:0030054cell junction IEA--
    GO:0045202synapse IEA--

    DNMBP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DNMBP About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of CDC42 activity
    Regulation of CDC42 activity


    1 BioSystems Pathway for DNMBP
        Regulation of CDC42 activity


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DNMBP
    Interactions:

        GeneGlobe Interaction Network for DNMBP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNMBP (Q6XZF71, 2, 3 ENSP000003156594) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=2 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    ENSG00000224501P081073I2D: score=2 
    ENSG00000231555P081073I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0035023regulation of Rho protein signal transduction ----
    GO:0035556intracellular signal transduction IEA--

    DNMBP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNMBP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DNMBP gene: 
    NM_015221.2  

    Unigene Cluster for DNMBP:

    Dynamin binding protein
    Hs.500771  [show with all ESTs]
    Unigene Representative Sequence: AL833283
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324109(uc001kqj.2) ENST00000472036 ENST00000422692 ENST00000342239
    ENST00000543621(uc010qpl.1 uc001kqg.2 uc001kqh.2) ENST00000540316

    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate DNMBP:
    hsa-miR-3163 hsa-miR-3140-3p hsa-miR-3675-3p hsa-miR-1237 hsa-miR-340 hsa-miR-606 hsa-miR-3918
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    GenScript: all cDNA clones in your preferred vector: DNMBP (NM_015221)
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      QuantiFast Probe-based Assays in human, mouse, rat DNMBP

    Additional mRNA sequence: 

    AB023227.1 AK128576.1 AK303479.1 AL833283.1 AY196211.1 BC020878.1 BC041628.1 

    9 DOTS entries:

    DT.95161885  DT.100773185  DT.97774558  DT.415181  DT.40202675  DT.102830907  DT.102830909  DT.95149546 
    DT.95161887 

    Selected AceView cDNA sequences (see all 135):

    AI738799 AI887820 AB023227 AI050887 AA368584 BQ065423 BU737766 BQ065447 
    BE875869 AA453500 BM799250 BM700538 AA256362 CR597882 CF541074 AI332721 
    AW104270 BX094807 BQ957745 BX492035 AI127874 BX433232 CD678613 BQ003859 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DNMBP (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12
    SP1:                                                                                                                        
    SP2:                                                                                                                        
    SP3:        -     -           -                                                                                             
    SP4:                          -                                                                                             
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for DNMBP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNMBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTTGTCT
    DNMBP Expression
    About this image


    DNMBP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
     
     Eye (Sensory Organs)
             Retina
    DNMBP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNMBP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.500771

    UniProtKB/Swiss-Prot: DNMBP_HUMAN, Q6XZF7
    Tissue specificity: Detected in heart, brain, lung, liver, skeletal muscle, kidney and pancreas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNMBP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DNMBP gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnmbp1 , 5 dynamin binding protein1, 5 78.85(n)1
    77.08(a)1
      19 (36.67 cM)5
    719721  NM_028029.31  NP_082305.11 
     438479675 
    chicken
    (Gallus gallus)
    Aves DNMBP1 dynamin binding protein 67.32(n)
    66.15(a)
      423827  XM_421697.4  XP_421697.4 
    lizard
    (Anolis carolinensis)
    Reptilia DNMBP6
    dynamin binding protein
    60(a)
    1 ↔ 1
    3(38218660-38271133)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.194082 Xenopus laevis transcribed sequence with weak similarity to protein refNP_003969.1 (H.sapiens) proline-serine-threonine phosphatase interacting protein 1; CD2 cytoplasmic tail-binding protein [Homo sapiens] less 73.57(n)    BJ096371.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dnmbp1 dynamin binding protein 58.43(n)
    55.35(a)
      100005174  XM_001921520.3  XP_001921555.3 
    worm
    (Caenorhabditis elegans)
    Secernentea Y37A1B.176
    Protein Y37A1B.17, isoform b (Y37A1B.17) mRNA, com...
    19(a)
    1 → many
    IV(13964361-13979847) WBGene00044989


    ENSEMBL Gene Tree for DNMBP (if available)
    TreeFam Gene Tree for DNMBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNMBP gene
    ARHGEF382  ARHGEF372  
    4 SIMAP similar genes for DNMBP using alignment to 4 protein entries:     DNMBP_HUMAN (see all proteins):
    SH3GL2    ARHGEF38    SH3GL1    ITSN1

    DNMBP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNMBP (see all 2209)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113570761,2
    C--101634836(+) TTTTT-/TTTTTT 1 -- int11Minor allele frequency- T:0.00NA 2
    rs70883691,2
    C,F,A,H--101634952(+) GCCACT/CTGATT 1 -- int18Minor allele frequency- C:0.25NA WA EA 370
    rs70706251,2
    C,F,A,H--101634959(+) GATTAG/TCCAGG 1 -- int113Minor allele frequency- T:0.18NS EA NA CSA WA 757
    rs2013948891,2
    C--101634959(+) ATTAG-/CCCAGG 1 -- int10--------
    rs1918338821,2
    --101634987(+) CCATGA/CCCGGC 1 -- int10--------
    rs1839095271,2
    --101635052(+) TCAAAC/TTCTTG 1 -- int10--------
    rs1882515621,2
    --101635062(+) GGCCTC/TAAGTG 1 -- int10--------
    rs70705371,2
    C,F,A,H--101635077(+) GCCCAC/ACTTGG 1 -- int17Minor allele frequency- A:0.46NA CSA 131
    rs70885601,2
    C,F,A,H--101635138(+) GAGTAT/CATAGA 1 -- int112Minor allele frequency- C:0.31NA CSA WA EA 507
    rs111903031,2
    C,F,H--101635209(+) ATTCTC/TCCAGA 1 -- int15Minor allele frequency- T:0.13NS EA 504

    HapMap Linkage Disequilibrium report for DNMBP (101635334 - 101769676 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for DNMBP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678240CNV Deletion23128226
    nsv7517CNV Insertion18451855
    nsv507574CNV Insertion20534489
    nsv7518CNV Loss18451855
    nsv825539CNV Loss20364138
    nsv516789CNV Loss19592680
    nsv825540CNV Gain20364138
    nsv831960CNV Gain17160897

    Human Gene Mutation Database (HGMD): DNMBP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNMBP
    DNA2.0 Custom Variant and Variant Library Synthesis for DNMBP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611282    OMIM disorders: --

    4 diseases for DNMBP:    
    About MalaCards
    dementia    alzheimer's disease    pancreatic cancer    pancreatitis


    DNMBP for disorders           About GeneDecksing

    Genetic Association Database (GAD): DNMBP
    Human Genome Epidemiology (HuGE) Navigator: DNMBP (6 documents)

    Export disorders for DNMBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNMBP gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with DNMBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton. (PubMed id 14506234)1, 2, 3 Salazar M.A.... De Camilli P. (J. Biol. Chem. 2003)
    2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    3. DNMBP is genetically associated with Alzheimer dementia in the Belgian population. (PubMed id 18359537)1, 4, 9 Bettens K....Van Broeckhoven C. (Neurobiol. Aging 2009)
    4. Association analysis of dynamin-binding protein (DNMBP) on chromosome 10q with late onset Alzheimer's disease in a large caucasian UK sample. (PubMed id 18452187)1, 4, 9 Morgan A.R....Williams J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    5. Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease. (PubMed id 16740596)1, 4, 9 Kuwano R....Ihara Y. (Hum. Mol. Genet. 2006)
    6. No association of dynamin binding protein (DNMBP) gene SNPs and Alzheimer's disease. (PubMed id 17442457)1, 4, 9 Minster R.L....Kamboh M.I. (Neurobiol. Aging 2008)
    7. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M.... Janssen O. (BMC Immunol. 2009)
    8. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23268 HGNC: 30373 AceView: DNMBP Ensembl:ENSG00000107554 euGenes: HUgn23268
    ECgene: DNMBP H-InvDB: DNMBP

    (According to HUGE)
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    HUGE: KIAA1010

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DNMBP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DNMBP gene:
    Search GeneIP for patents involving DNMBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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