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Aliases for DNM3 Gene

Aliases for DNM3 Gene

  • Dynamin 3 2 3
  • Dynamin, Testicular 3 4
  • EC 4 63
  • T-Dynamin 3 4
  • Dyna III 2 3
  • KIAA0820 4 6
  • Dynamin Family Member 3
  • Dynamin-3 3

External Ids for DNM3 Gene

Summaries for DNM3 Gene

Entrez Gene Summary for DNM3 Gene

  • This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

GeneCards Summary for DNM3 Gene

DNM3 (Dynamin 3) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is MX1.

UniProtKB/Swiss-Prot for DNM3 Gene

  • Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity).

Tocris Summary for DNM3 Gene

  • Dynamin is a GTPase that is involved in endocytosis. GTPases are a group of enzymes that catalyze hydrolysis of the gamma phosphate bond in guanine triphosphate (GTP) to form guanine diphosphate (GDP). Mg2+ is essential for catalytic activity. GTPases are often coupled to G proteins and have essential roles in signal transduction, protein synthesis and translocation, control of cell growth and differentiation and vesicular transport regulation.

Gene Wiki entry for DNM3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNM3 Gene

Genomics for DNM3 Gene

Genomic Location for DNM3 Gene

171,841,478 bp from pter
172,418,466 bp from pter
576,989 bases
Plus strand

Genomic View for DNM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNM3 Gene

Regulatory Elements for DNM3 Gene

Proteins for DNM3 Gene

  • Protein details for DNM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A9Z1Y1
    • O14982
    • O95555
    • Q1MTM8
    • Q5W129
    • Q6P2G1
    • Q9H0P3
    • Q9H548
    • Q9NQ68
    • Q9NQN6

    Protein attributes for DNM3 Gene

    869 amino acids
    Molecular mass:
    97746 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA74843.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DNM3 Gene

    Alternative splice isoforms for DNM3 Gene


neXtProt entry for DNM3 Gene

Proteomics data for DNM3 Gene at MOPED

Post-translational modifications for DNM3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys223 and Lys257

Other Protein References for DNM3 Gene

Domains for DNM3 Gene

Gene Families for DNM3 Gene

  • PLEKH :Pleckstrin homology (PH) domain containing

Suggested Antigen Peptide Sequences for DNM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 dynamin-type G (guanine nucleotide-binding) domain.:
    • Q9UQ16
  • Contains 1 GED domain.:
    • Q9UQ16
  • Contains 1 PH domain.:
    • Q9UQ16
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.:
    • Q9UQ16
genes like me logo Genes that share domains with DNM3: view

Function for DNM3 Gene

Molecular function for DNM3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: GTP + H(2)O = GDP + phosphate
UniProtKB/Swiss-Prot Function: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity).

Enzyme Numbers (IUBMB) for DNM3 Gene

Gene Ontology (GO) - Molecular Function for DNM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity ISS --
GO:0005515 protein binding IPI 15252009
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with DNM3: view
genes like me logo Genes that share phenotypes with DNM3: view

Animal Models for DNM3 Gene

MGI Knock Outs for DNM3:

miRNA for DNM3 Gene

miRTarBase miRNAs that target DNM3

No data available for Transcription Factor Targeting and HOMER Transcription for DNM3 Gene

Localization for DNM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNM3 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated. {ECO:0000305}.

Subcellular locations from

Jensen Localization Image for DNM3 Gene COMPARTMENTS Subcellular localization image for DNM3 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for DNM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005874 microtubule IEA --
GO:0014069 postsynaptic density ISS --
GO:0043197 dendritic spine ISS --
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with DNM3: view

Pathways for DNM3 Gene

genes like me logo Genes that share pathways with DNM3: view

Interacting Proteins for DNM3 Gene

Gene Ontology (GO) - Biological Process for DNM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006897 endocytosis ISS --
GO:0007416 synapse assembly ISS --
GO:0008152 metabolic process ISS --
GO:0046847 filopodium assembly ISS --
genes like me logo Genes that share ontologies with DNM3: view

Compounds for DNM3 Gene

(5) Tocris Compounds for DNM3 Gene

Compound Action Cas Number
8CPT-2Me-cAMP, sodium salt Selective Epac activator [510774-50-2]
Dynamin inhibitory peptide, myristoylated (control) Control peptide version of dynamin inhibitory peptide, myristoylated (Cat. No. 1775)
Dynasore Non-competitive dynamin inhibitor [304448-55-3]
HJC 0350 Selective Epac2 inhibitor [885434-70-8]
ML 141 Selective inhibitor of Cdc42 Rho family GTPase [71203-35-5]

(1) HMDB Compounds for DNM3 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP

(60) Novoseek inferred chemical compound relationships for DNM3 Gene

Compound -log(P) Hits PubMed IDs
gtp 75.4 88
phragmoplastin 67.8 1
tyrosine 48.8 23
etorphine 48.5 1
monodansylcadaverine 41 2
genes like me logo Genes that share compounds with DNM3: view

Transcripts for DNM3 Gene

Unigene Clusters for DNM3 Gene

Dynamin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNM3 Gene

No ASD Table

Relevant External Links for DNM3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNM3 Gene

mRNA expression in normal human tissues for DNM3 Gene

mRNA differential expression in normal tissues according to GTEx for DNM3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (6.4), Brain - Cerebellum (4.5), and Brain - Frontal Cortex (BA9) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for DNM3 Gene

SOURCE GeneReport for Unigene cluster for DNM3 Gene Hs.654775

genes like me logo Genes that share expressions with DNM3: view

No data available for mRNA Expression by UniProt/SwissProt for DNM3 Gene

Orthologs for DNM3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNM3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DNM3 35
  • 97.42 (n)
  • 97.18 (a)
DNM3 36
  • 98 (a)
(Bos Taurus)
Mammalia DNM3 35
  • 91.68 (n)
  • 98.31 (a)
DNM3 36
  • 97 (a)
(Canis familiaris)
Mammalia DNM3 35
  • 91.27 (n)
  • 97.39 (a)
DNM3 36
  • 96 (a)
(Mus musculus)
Mammalia Dnm3 35
  • 89.33 (n)
  • 97.9 (a)
Dnm3 16
Dnm3 36
  • 98 (a)
(Monodelphis domestica)
Mammalia DNM3 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia DNM3 36
  • 93 (a)
(Rattus norvegicus)
Mammalia Dnm3 35
  • 88.94 (n)
  • 97.09 (a)
(Gallus gallus)
Aves DNM3 35
  • 81.9 (n)
  • 92.12 (a)
DNM3 36
  • 91 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnm3 35
  • 73.98 (n)
  • 79.52 (a)
(Danio rerio)
Actinopterygii dnm2a 35
  • 72.94 (n)
  • 83.05 (a)
dnm3 36
  • 77 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10361 35
(Glycine max)
eudicotyledons Gma.4720 35
(Hordeum vulgare)
Liliopsida Hv.2342 35
(Zea mays)
Liliopsida Zm.5017 35
(Oryza sativa)
Liliopsida Os.27352 35
(Triticum aestivum)
Liliopsida Ta.307 35
Species with no ortholog for DNM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for DNM3 Gene

Gene Tree for DNM3 (if available)
Gene Tree for DNM3 (if available)

Paralogs for DNM3 Gene

Paralogs for DNM3 Gene

Selected SIMAP similar genes for DNM3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DNM3: view

Variants for DNM3 Gene

Sequence variations from dbSNP and Humsavar for DNM3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs473629 -- 172,172,401(+) GGTGG(A/T)TAGCA intron-variant
rs477289 -- 172,222,254(+) ATCAT(A/C)AAGAA intron-variant
rs479185 -- 172,173,010(+) CAGGT(A/G)GTGAA intron-variant
rs479336 -- 172,230,433(+) ATATT(G/T)TTGTA intron-variant
rs479960 -- 172,182,532(+) AAAAT(G/T)TTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNM3 Gene

Variant ID Type Subtype PubMed ID
nsv831893 CNV Loss 17160897
nsv3521 CNV Insertion 18451855
esv2670196 CNV Deletion 23128226
esv2615149 CNV Deletion 19546169
esv275460 CNV Loss 21479260
nsv3532 CNV Loss 18451855
nsv508047 CNV Loss 20534489
nsv465650 CNV Loss 19166990
nsv872546 CNV Loss 21882294
esv2664393 CNV Deletion 23128226
nsv3543 CNV Loss 18451855

Relevant External Links for DNM3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNM3 Gene

Disorders for DNM3 Gene

(21) Novoseek inferred disease relationships for DNM3 Gene

Disease -log(P) Hits PubMed IDs
optic atrophy autosomal dominant 51 1
wiskott-aldrich syndrome 48.2 3
cholera 36.4 5
influenza 10.4 2
diphtheria 5.65 5

Relevant External Links for DNM3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DNM3: view

No data available for UniProtKB/Swiss-Prot for DNM3 Gene

Publications for DNM3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 48
  3. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. (PMID: 19820697) Soranzo N. … Gieger C. (Nat. Genet. 2009) 3 48
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J. … Grant S.F. (BMC Med. Genet. 2010) 3 48

Products for DNM3 Gene

Sources for DNM3 Gene

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