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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DNM3 Gene

protein-coding GIFtS: 62
GCID: GC01P171810

dynamin 3

Explore 22 diseases affiliated with
DNM3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Dynamin 3¹ ²		EC 3.6.5.5³ ⁸
KIAA0820¹ ³		Dyna III²
Dynamin, Testicular² ³		Dynamin Family Member²
T-Dynamin¹		Dynamin-3¹

External Ids:	HGNC: 29125¹	Entrez Gene: 26052²	Ensembl: ENSG00000197959⁷	OMIM: 611445⁵	UniProtKB: Q9UQ16³

Export aliases for DNM3 gene to outside databases

Previous GC identifers: GC01P169051 GC01P168542 GC01P170077 GC01P143034

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DNM3:

Members of the dynamin family, such as DNM3, possess mechanochemical properties involved in actin-membrane processes,

predominantly in membrane budding (Orth and McNiven, 2003 (PubMed 12517701)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: DYN3_HUMAN, Q9UQ16

Function: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and

hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity)

summary for DNM3:

Dynamin is a GTPase that is involved in endocytosis. GTPases are a group of enzymes that catalyze hydrolysis

of the ? phosphate bond in guanine triphosphate (GTP) to form guanine diphosphate (GDP). Mg2+ is essential

for catalytic activity. GTPases are often coupled to G proteins and have essential roles in signal

transduction, protein synthesis and translocation, control of cell growth and differentiation and vesicular

transport regulation. There are six main groups of GTPases; heterotrimeric G protein GTPases (E.C. 3.6.5.1),

small monomeric GTPases (E.C. 3.6.5.2), protein-synthesizing GTPases (E.C. 3.6.5.3),

signal-recognition-particle GTPase (E.C. 3.6.5.4), dynamin GTPases (E.C. 3.6.5.5) and tubulin GTPases (E.C.

3.6.5.6).

Gene Wiki entry for DNM3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DNM3 gene promoter:
C/EBPbeta GATA-3 ATF-2 POU6F1 (c2) GATA-2 GATA-1 AREB6 CRE-BP1 c-Myb aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DNM3 promoter sequence

Search SABiosciences Chromatin IP Primers for DNM3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNM3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.3 Ensembl cytogenetic band: 1q24.3 HGNC cytogenetic band: 1q24.1

DNM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNM3 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P171810: view genomic region (about GC identifiers)

Start:	171,810,621 bp from pter	End:	172,387,606 bp from pter
Size:	576,986 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DYN3_HUMAN, Q9UQ16 (See protein sequence)

Recommended Name: Dynamin-3

Size: 869 amino acids; 97746 Da

Subcellular location: Cytoplasm (Potential). Cytoplasm, cytoskeleton (Potential). Note=Microtubule-associated

(Potential)

Sequence caution: Sequence=BAA74843.2; Type=Erroneous initiation;

1 PDB 3D structure from and Proteopedia for DNM3:

3L43 (3D)

Secondary accessions: A9Z1Y1 O14982 O95555 Q1MTM8 Q5W129 Q9H0P3 Q9H548 Q9NQ68 Q9NQN6

Alternative splicing: 4 isoforms: Q9UQ16-1 Q9UQ16-2 Q9UQ16-3 Q9UQ16-4

Explore the universe of human proteins at neXtProt for DNM3: NX_Q9UQ16

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UQ16

4/37 DME Specific Peptides for DNM3 (Q9UQ16) (see all 37)

SLSWYKD

AEFLHCK

GVVNRSQ

RPTIIRP

DNM3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001129599.1 NP_056384.2

ENSEMBL proteins:

ENSP00000356707 ENSP00000347457 ENSP00000356705 ENSP00000429701 ENSP00000429416

ENSP00000429165 ENSP00000350876

Reactome Protein details: Q9UQ16
Human Recombinant Protein Products for DNM3:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DNM3

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--
GO:0005874	microtubule	IEA	--
GO:0014069	postsynaptic density	ISS	--
GO:0043197	dendritic spine	ISS	--
GO:0048471	perinuclear region of cytoplasm	ISS	--

DNM3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for DNM3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DNM3 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR003130 GED

IPR001401 Dynamin_GTPase

IPR020850 GTPase_effector_domain_GED

IPR001849 Pleckstrin_homology

IPR022812 Dynamin

Graphical View of Domain Structure for InterPro Entry Q9UQ16

ProtoNet protein and cluster: Q9UQ16

3 Blocks protein families:

IPB001401 Dynamin

IPB001848 Ribosomal protein S10

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: DYN3_HUMAN, Q9UQ16

Similarity: Belongs to the dynamin family

Similarity: Contains 1 GED domain

Similarity: Contains 1 PH domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DYN3_HUMAN, Q9UQ16

Function: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and

hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity)

Catalytic activity: GTP + H(2)O = GDP + phosphate

Enzyme Number (IUBMB): EC 3.6.5.5¹ ²

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	ISS	--
GO:0005515	protein binding	IPI	15252009
GO:0005525	GTP binding	IEA	--
GO:0005543	phospholipid binding	IEA	--

DNM3 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for DNM3:

Synthetic lethal with Ras

6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Dnm3):

behavior/neurological	homeostasis/metabolism	mortality/aging	nervous system	no phenotypic analysis
normal

DNM3 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Dnm3^tm1.2Pdc for DNM3

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DNM3

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		8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate DNM3 (see all 47):
		hsa-miR-140-5p hsa-miR-3685 hsa-miR-607 hsa-miR-24-1* hsa-miR-29a hsa-miR-342-3p hsa-miR-409-5p hsa-miR-4274

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNM3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Axon guidance

	Axon guidance	1.00			L1CAM interactions	0.39
	Developmental Biology	0.69			Recycling pathway of L1	0.15

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Signaling by FGFR

NGF signalling via TRKA from the plasma membrane

0.70

Signalling by NGF

0.52

Transport of MHC II:Ii complex along Golgi to TGN

Internalization of MHC II:Ii clathrin coated vesicle

0.52

Retrograde neurotrophin signalling

0.00

MHC class II antigen presentation

MHC class II antigen presentation

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for DNM3

Synaptic Vesicle Pathway

5/12 Reactome Pathways for DNM3 (see all 12)

	L1CAM interactions
	Developmental Biology
	Internalization of MHC II:Ii clathrin coated vesicle
	Adaptive Immune System
	Retrograde neurotrophin signalling

4 Kegg Pathways (Kegg details for DNM3):

	Endocytosis
	Fc gamma R-mediated phagocytosis
	Endocrine and other factor-regulated calcium reabsorption
	Bacterial invasion of epithelial cells

DNM3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DNM3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/29 Interacting proteins for DNM3 (Q9UQ16^{2, 3} ENSP00000356705⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 29)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SH3GL1	Q99961²^,³	MINT-8096522 I2D: score=1
AMPH	P49418²^,³, ENSP00000348602⁴	MINT-8096497 I2D: score=1 STRING: ENSP00000348602
ABL1	P00519³, ENSP00000361423⁴	I2D: score=1 STRING: ENSP00000361423
FYN	P06241³, ENSP00000357656⁴	I2D: score=1 STRING: ENSP00000357656
HOMER1	Q86YM7³, ENSP00000334382⁴	I2D: score=1 STRING: ENSP00000334382

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006184	GTP catabolic process	ISS	--
GO:0006897	endocytosis	ISS	--
GO:0007416	synapse assembly	ISS	--
GO:0046847	filopodium assembly	ISS	--

DNM3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DNM3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for DNM3 available from Tocris Bioscience About this table

Compound	Action	CAS #
Dynamin inhibitory peptide, myristoylated	Cell-permeable dynamin inhibitor	[251634-22-7]
Dynamin inhibitory peptide	Dynamin inhibitor	[251634-21-6]
Dynasore	Non-competitive dynamin inhibitor	[304448-55-3]

1 HMDB Compound for DNM3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

10/60 Novoseek chemical compound relationships for DNM3 gene (see all 60) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gtp	75.4	119	9531551 (4), 16946707 (4), 15450295 (3), 8798389 (3) (see all 61)
phragmoplastin	67.8	1	10722722 (1)
tyrosine	48.8	24	9607818 (3), 9880482 (3), 10753943 (2), 11719519 (2) (see all 16)
etorphine	48.5	1	16415176 (1)
monodansylcadaverine	41	2	18353779 (1), 11805206 (1)
lipid	39.9	51	15123615 (2), 17988218 (2), 12837133 (2), 11015230 (2) (see all 34)
cytochalasin d	39.1	1	9841906 (1)
gdp	38.9	9	9346955 (3), 16413294 (1), 19573020 (1), 15954862 (1) (see all 6)
phosphatidylinositol	38.1	6	12724326 (1), 19737091 (1), 16313344 (1), 11830589 (1) (see all 6)
chlorpromazine	37.6	4	18602423 (1), 17587406 (1), 19864322 (1), 15020715 (1)

Search CenterWatch for drugs/clinical trials and news about DNM3 / DYN3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DNM3 gene (2 alternative transcripts):

NM_001136127.1 NM_015569.3

Unigene Cluster for DNM3:

Dynamin 3

Hs.654775 [show with all ESTs]

Unigene Representative Sequence: NM_015569

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367733(uc001gid.4) ENST00000355305 ENST00000367731 ENST00000520906(uc009wwb.2)

ENST00000523513 ENST00000485254(uc001gih.1) ENST00000491124 ENST00000358155(uc001gie.3 uc001gif.3)

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		hsa-miR-140-5p hsa-miR-3685 hsa-miR-607 hsa-miR-24-1* hsa-miR-29a hsa-miR-342-3p hsa-miR-409-5p hsa-miR-4274

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Additional cDNA sequence:

AB020627.2 AK056279.1 AK307806.1 AK308992.1 AL035110.1 AL136712.1 BC037326.1 BC047089.1

BC064546.1

12 DOTS entries:

DT.309695 DT.95337768 DT.121390315 DT.100754800 DT.100754801 DT.121390225 DT.75133793 DT.95167324

DT.99927250 DT.427045 DT.75138540 DT.95284416

24/84 AceView cDNA sequences (see all 84):

BQ723087 AB020627 CB117728 AA348527 N64354 BU738923 AW044058 AI360075

BC064546 BM671950 BM974867 AK056279 BM720191 BQ439423 BX282640 AL035110

CR622585 AL119017 NM_015569 BX488247 AI631915 BM559631 BP362943 AW771646

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DNM3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACCTATTGT

About this image

DNM3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DNM3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DNM3

SOURCE GeneReport for Unigene cluster: Hs.654775

SABiosciences Custom PCR Arrays for DNM3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNM3 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNM3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNM3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNM3 gene from 6/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DNM3¹	dynamin 3	82.03(n) 92.07(a)		424389 XM_003641653.1 XP_003641701.1
zebrafish (Danio rerio)	Actinopterygii	dnm3¹	dynamin 3	71.12(n) 77.79(a)		557996 NM_001128524.1 NP_001121996.1
fruit fly (Drosophila melanogaster)	Insecta	shi⁶	shibire	62(a)	1 → many	X(15786149-15800725)
worm (Caenorhabditis elegans)	Secernentea	dyn-1⁶	Dynamin	63(a)	1 → many	X(15568848-15573625)
soybean (Glycine max)	eudicotyledons	Gma.4720²	Glycine max dynamin-like protein SDL5A mRNA, complete more	72.12(n)		U36430.1
rice (Oryza sativa)	Liliopsida	Os.27352²	Oryza sativa (japonica cultivar-group) cDNA clone0 more	70.56(n)		AK105435.1

ENSEMBL Gene Tree for DNM3 (if available)
TreeFam Gene Tree for DNM3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DNM3 gene

DNM1² MX2² DNM2² MX1²

6 SIMAP similar genes for DNM3 using alignment to 5 protein entries: DYN3_HUMAN (see all proteins):

DNM2 DNM1 DNM1P34 DNM1L MX2 MX1

DNM3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12133952^1,2	C,F,H	--	143562763(+)	`ctctaC/Ttctta`	1	--	ds500¹		5	NS EA NA	538
rs77118298^1,2	F	--	143563059(+)	`TGTTGT/CCAGGT`	1	--	nc-transcript-variant		1	WA	118
rs41263730^1,2	C	--	143563855(+)	`ACTCTG/ATTTGA`	1	--	int¹		1	NA	2
rs13374511^1,2	H	--	143564125(+)	`TATATA/GTCTTT`	1	--	int¹		3	NS EA	260
rs13374520^1,2	C,H	--	143564259(+)	`TCATTA/GATGCT`	1	--	int¹		6	NS EA NA	512
rs6674018^1,2	C	--	143564700(+)	`actacT/Aatatg`	1	--	int¹		4	NA WA	242
rs75187563^1,2	C,F	--	143565505(+)	`GAATAT/CGGTAT`	1	--	int¹		1	WA	118
rs7517736^1,2	C	--	143566009(+)	`gcatgC/Taccag`	1	--	int¹		2	WA	120
rs78515325^1,2		--	143566399(+)	`TTTCTT/CAGCAA`	1	--	int¹		1	WA	118
rs12069280^1,2	C,H	--	143567149(+)	`ttttaG/CttGGG`	1	--	int¹		7	NS EA NA WA	498

HapMap Linkage Disequilibrium report for DNM3 (171810621 - 172060621 bp, first 250kb of DNM3)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for DNM3
2 CNVs: 97554 84653

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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DNM3 for disorders           About GeneDecksing

OMIM gene information: 611445    OMIM disorders: --

20/22 diseases for DNM3 (see all 22):    About MalaCards

wiskott-aldrich syndrome optic atrophy centronuclear myopathy seckel syndrome

diphtheria herpes simplex huntington's disease cutaneous t cell lymphoma

cholera choriocarcinoma paraplegia alzheimer's disease

keloids myopathy influenza gout

pharyngitis osteosarcoma cholesterol pancreatitis

10/21 Novoseek disease relationships for DNM3 gene (see all 21) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
optic atrophy autosomal dominant	51	1	17167772 (1)
wiskott-aldrich syndrome	48.2	3	16540475 (1), 12686614 (1), 16418535 (1)
cholera	36.4	5	9531551 (1), 15496455 (1), 15146065 (1), 19438805 (1) (see all 5)
influenza	10.4	2	10648179 (2)
diphtheria	5.65	6	9521846 (3), 15511085 (1), 10547351 (1)
metastasis	5.06	1	16505488 (1)
cancer	4.68	2	19857461 (2)
melanoma	2.61	1	16306044 (1)
leukemia	1.93	2	10816441 (1)
tumors	0.721	3	11672786 (1), 12695554 (1), 12848341 (1)

Human Genome Epidemiology (HuGE) Navigator: DNM3 (4 documents)

Export disorders for DNM3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DNM3 gene, integrated from 9 sources (see all 454):
(articles sorted by number of sources associating them with DNM3)

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Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)^{1, 2, 3} Nagase T....Ohara O. (1998)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (2002)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
Dynamin 3 participates in the growth and development of megakaryocytes. (PubMed id 19007685)^{1, 9} Reems J.A....Gilligan D.M. (2008)
Agonist-induced internalization of histamine H2 receptor and activation of extracellular signal-regulated kinases are dynamin-dependent. (PubMed id 18691388)^{1, 9} Xu A.J....Yanai K. (2008)
Dynamin: characteristics, mechanism of action and function. (PubMed id 12511974)^{1, 9} Wiejak J. and Wyroba E. (2002)
A clathrin-dynamin-dependent endocytic pathway for th e uptake of HIV-1 by direct T cell-T cell transmission. (PubMed id 18602423)^{1, 9} Bosch B....Este J.A. (2008)
A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis. (PubMed id 15252009)^{1, 9} Kamioka Y....Mochizuki N. (2004)
Trans-infection but not infection from within endosoma l compartments after cell-to-cell HIV-1 transfer to CD4+ T cells. (PubMed id 22846998)¹ Permanyer M....Este J.A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 26052	HGNC: 29125	AceView: DNM3	Ensembl:ENSG00000197959	euGenes: HUgn26052
ECgene: DNM3	Kegg: 26052	H-InvDB: DNM3

(According to HUGE)
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HUGE: KIAA0820

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DNM3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DNM3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DNM3 gene:
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GeneCards and IP:
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