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DNM3 Gene

protein-coding   GIFtS: 66
GCID: GC01P171810

Dynamin 3

  See DNM3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dynamin 31 2     EC 3.6.5.53 8
Dyna III1 2     KIAA08203 5
Dynamin, Testicular2 3     Dynamin Family Member2
T-dynamin2 3     dynamin-32

External Ids:    HGNC: 291251   Entrez Gene: 260522   Ensembl: ENSG000001979597   OMIM: 6114455   UniProtKB: Q9UQ163   

Export aliases for DNM3 gene to outside databases

Previous GC identifers: GC01P169051 GC01P168542 GC01P170077 GC01P143034


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNM3 Gene:
This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with
microtubules and are involved in vesicular transport. The encoded protein functions in the development of
megakaryocytes. Alternative splicing results in multiple transcript variants. (provided by RefSeq, May 2013)

GeneCards Summary for DNM3 Gene:
DNM3 (dynamin 3) is a protein-coding gene. Diseases associated with DNM3 include dominant optic atrophy. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is DNM1.

UniProtKB/Swiss-Prot: DYN3_HUMAN, Q9UQ16
Function: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to
bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By
similarity)

summary for DNM3 Gene:
Dynamin is a GTPase that is involved in endocytosis. GTPases are a group of enzymes that catalyze hydrolysis
of the gamma phosphate bond in guanine triphosphate (GTP) to form guanine diphosphate (GDP). Mg2+ is
essential for catalytic activity. GTPases are often coupled to G proteins and have essential roles in signal
transduction, protein synthesis and translocation, control of cell growth and differentiation and vesicular
transport regulation.

Gene Wiki entry for DNM3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNM3 gene promoter:
         C/EBPbeta   GATA-3   ATF-2   POU6F1 (c2)   GATA-2   GATA-1   AREB6   CRE-BP1   c-Myb   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNM3 promoter sequence
   Search Chromatin IP Primers for DNM3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.3   Ensembl cytogenetic band:  1q24.3   HGNC cytogenetic band: 1q24.1

DNM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNM3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P171810:  view genomic region     (about GC identifiers)

Start:
171,810,621 bp from pter      End:
172,387,606 bp from pter
Size:
576,986 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DYN3_HUMAN, Q9UQ16 (See protein sequence)
Recommended Name: Dynamin-3  
Size: 869 amino acids; 97746 Da
Sequence caution: Sequence=BAA74843.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for DNM3:
3L43 (3D)    
Secondary accessions: A9Z1Y1 O14982 O95555 Q1MTM8 Q5W129 Q9H0P3 Q9H548 Q9NQ68 Q9NQN6
Alternative splicing: 4 isoforms:  Q9UQ16-1   Q9UQ16-2   Q9UQ16-3   Q9UQ16-4   

Explore the universe of human proteins at neXtProt for DNM3: NX_Q9UQ16

Explore proteomics data for DNM3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys223, Lys257
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DNM3 (Q9UQ16) (see all 37)
     SLSWYKD  AEFLHCK  GVVNRSQ  RPTIIRP 


    See DNM3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001129599.1  NP_001265181.1  NP_056384.2  

    ENSEMBL proteins: 
     ENSP00000356707   ENSP00000347457   ENSP00000356705   ENSP00000429701   ENSP00000429416  
     ENSP00000429165   ENSP00000350876  
    Reactome Protein details: Q9UQ16

    DNM3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for DNM3

     
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    Search eBioscience for ELISAs for DNM3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    Selected InterPro protein domains (see all 10):
     IPR003130 GED
     IPR027743 Dnm3
     IPR001401 Dynamin_GTPase
     IPR020850 GTPase_effector_domain_GED
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9UQ16

    ProtoNet protein and cluster: Q9UQ16

    3 Blocks protein domains:
    IPB001401 Dynamin
    IPB001848 Ribosomal protein S10
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: DYN3_HUMAN, Q9UQ16
    Similarity: Belongs to the dynamin family
    Similarity: Contains 1 GED domain
    Similarity: Contains 1 PH domain


    Find genes that share domains with DNM3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DYN3_HUMAN, Q9UQ16
    Function: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to
    bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By
    similarity)
    Catalytic activity: GTP + H(2)O = GDP + phosphate

         Enzyme Number (IUBMB): EC 3.6.5.51 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ISS--
    GO:0005515protein binding IPI15252009
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with DNM3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DNM3:
     Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dnm3):
     behavior/neurological  homeostasis/metabolism  mortality/aging  nervous system  no phenotypic analysis 
     normal 

    Find genes that share phenotypes with DNM3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dnm3tm1.2Pdc for DNM3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNM3
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    miRNA
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    hsa-let-7b-5p (MIRT032198), hsa-mir-124-3p (MIRT022316)

    Block miRNA regulation of human, mouse, rat DNM3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNM3 (see all 47):
    hsa-miR-140-5p hsa-miR-3685 hsa-miR-607 hsa-miR-24-1* hsa-miR-29a hsa-miR-342-3p hsa-miR-409-5p hsa-miR-4274
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNM3

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    eBioscience FlowRNA Probe Sets ( VA1-12025) for DNM3 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DYN3_HUMAN, Q9UQ16: Cytoplasm (Potential). Cytoplasm, cytoskeleton (Potential). Note=Microtubule-associated
    (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol3
    mitochondrion2
    nucleus2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005874microtubule IEA--
    GO:0014069postsynaptic density ISS--
    GO:0043197dendritic spine ISS--
    GO:0048471perinuclear region of cytoplasm ISS--

    Find genes that share ontologies with DNM3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DNM3 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Synaptic vesicle cycle
    Synaptic Vesicle Pathway0.50
    Synaptic vesicle cycle0.50
    2L1CAM interactions
    Axon guidance0.63
    L1CAM interactions0.36
    Developmental Biology0.63
    3Signaling by FGFR
    NGF signalling via TRKA from the plasma membrane0.71
    Signalling by NGF0.71
    4Endocytic Trafficking of EGFR
    Retrograde neurotrophin signalling0.36
    Recycling pathway of L10.33
    5Signaling by GPCR
    Signal Transduction0.58


    Find genes that share SuperPaths with DNM3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for DNM3
        Notch Signaling Pathways


    1 BioSystems Pathway for DNM3
        Synaptic Vesicle Pathway

    4 Reactome Pathways for DNM3
        Recycling pathway of L1
    Toll Like Receptor 4 (TLR4) Cascade
    Retrograde neurotrophin signalling
    MHC class II antigen presentation


    4 Kegg Pathways  (Kegg details for DNM3):
        Endocytosis
    Synaptic vesicle cycle
    Endocrine and other factor-regulated calcium reabsorption
    Bacterial invasion of epithelial cells

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DNM3
    Interactions:

        Search GeneGlobe Interaction Network for DNM3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNM3 (Q9UQ162, 3 ENSP000003567054) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3GL1Q999612, 3MINT-8096522 I2D: score=1 
    AMPHP494182, 3, ENSP000003486024MINT-8096497 I2D: score=1 STRING: ENSP00000348602
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    HOMER1Q86YM73, ENSP000003343824I2D: score=1 STRING: ENSP00000334382
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ISS--
    GO:0006897endocytosis ISS--
    GO:0007416synapse assembly ISS--
    GO:0046847filopodium assembly ISS--

    Find genes that share ontologies with DNM3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for DNM3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    HJC 0350Selective Epac2 inhibitor[885434-70-8]
    Dynamin inhibitory peptide, myristoylated (control) Control peptide version of dynamin inhibitory peptide, myristoylated (Cat. No. 1775) --
    8CPT-2Me-cAMP, sodium salt Selective Epac activator[510774-50-2]
    DynasoreNon-competitive dynamin inhibitor[304448-55-3]
    ML 141Selective inhibitor of Cdc42 Rho family GTPase[71203-35-5]

    1 HMDB Compound for DNM3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Selected Novoseek inferred chemical compound relationships for DNM3 gene (see all 60)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 75.4 119 9531551 (4), 16946707 (4), 15450295 (3), 8798389 (3) (see all 61)
    phragmoplastin 67.8 1 10722722 (1)
    tyrosine 48.8 24 9607818 (3), 9880482 (3), 10753943 (2), 11719519 (2) (see all 16)
    etorphine 48.5 1 16415176 (1)
    monodansylcadaverine 41 2 18353779 (1), 11805206 (1)
    lipid 39.9 51 15123615 (2), 17988218 (2), 12837133 (2), 11015230 (2) (see all 34)
    cytochalasin d 39.1 1 9841906 (1)
    gdp 38.9 9 9346955 (3), 16413294 (1), 19573020 (1), 15954862 (1) (see all 6)
    phosphatidylinositol 38.1 6 12724326 (1), 19737091 (1), 16313344 (1), 11830589 (1) (see all 6)
    chlorpromazine 37.6 4 18602423 (1), 17587406 (1), 19864322 (1), 15020715 (1)



    Find genes that share compounds with DNM3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DNM3 gene (3 alternative transcripts): 
    NM_001136127.2  NM_001278252.1  NM_015569.4  

    Unigene Cluster for DNM3:

    Dynamin 3
    Hs.654775  [show with all ESTs]
    Unigene Representative Sequence: NM_015569
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367733(uc001gid.4) ENST00000355305 ENST00000367731 ENST00000520906(uc009wwb.2)
    ENST00000523513 ENST00000485254(uc001gih.1) ENST00000491124 ENST00000358155(uc001gie.3 uc001gif.3)

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    hsa-miR-140-5p hsa-miR-3685 hsa-miR-607 hsa-miR-24-1* hsa-miR-29a hsa-miR-342-3p hsa-miR-409-5p hsa-miR-4274
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    Additional mRNA sequence: 

    AB020627.2 AK056279.1 AK307806.1 AK308992.1 AL035110.1 AL136712.1 BC037326.1 BC047089.1 
    BC064546.1 

    12 DOTS entries:

    DT.309695  DT.95337768  DT.121390315  DT.100754800  DT.100754801  DT.121390225  DT.75133793  DT.95167324 
    DT.99927250  DT.427045  DT.75138540  DT.95284416 

    Selected AceView cDNA sequences (see all 84):

    AK056279 BX282640 BQ439423 AL035110 CR622585 AL119017 AI360075 BM671950 
    BC064546 BM974867 AW044058 AA348527 CB117728 N64354 AB020627 BQ723087 
    BU738923 NM_015569 BM720191 AL039732 AF150278 BC047089 AW895291 BX452236 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCTATTGT
    DNM3 Expression
    About this image


    DNM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Thalamus
             Oligodendrocyte-like cells
             Globus Pallidus   
     
     Spinal Cord (Nervous System)
             Oligodendrocyte-like cells
     
     Bone (Muscoskeletal System)
             TGFbeta3+BMP7-induced chondrocytes
     
     Blood (Hematopoietic System)
             Megakaryocytes Hematopoietic Bone Marrow
     
     Cartilage (Muscoskeletal System)
             TGFbeta3+BMP7-induced chondrocytes
    DNM3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNM3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654775
        Custom PCR Arrays for DNM3
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNM3 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnm31 , 5 dynamin 31, 5 89.33(n)1
    97.9(a)1
      1 (69.95 cM)5
    1039671  NM_001038619.11  NP_001033708.11 
     1619824535 
    chicken
    (Gallus gallus)
    Aves DNM31 dynamin 3 81.9(n)
    92.12(a)
      424389  XM_004943194.1  XP_004943251.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    78(a)
    many ↔ many
    GL343763.1(60422-172086)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dnm31 dynamin 3 73.98(n)
    79.52(a)
      100489905  XM_002934150.2  XP_002934196.2 
    zebrafish
    (Danio rerio)
    Actinopterygii dnm2a1 dynamin 2a 72.94(n)
    83.05(a)
      559334  NM_001030128.1  NP_001025299.1 
    soybean
    (Glycine max)
    eudicotyledons Gma.47202 Glycine max dynamin-like protein SDL5A mRNA, complete more 72.12(n)    U36430.1 
    rice
    (Oryza sativa)
    Liliopsida Os.273522 Oryza sativa (japonica cultivar-group) cDNA clone0 more 70.56(n)    AK105435.1 


    ENSEMBL Gene Tree for DNM3 (if available)
    TreeFam Gene Tree for DNM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNM3 gene
    DNM12  MX22  DNM22  DNM1L2  MX12  
    6 SIMAP similar genes for DNM3 using alignment to 5 protein entries:     DYN3_HUMAN (see all proteins):
    DNM1    DNM2    DNM1P34    DNM1L    MX2    MX1

    Find genes that share paralogs with DNM3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNM3 (see all 9658)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs355221741,2
    C--143076311(+) acacC-/CTGTCAG 2 -- int10--------
    rs10150091,2
    C,F,A,H--171808654(-) CAACTG/ATAATC 2 -- us2k120Minor allele frequency- A:0.36NA EA MN WA CSA 1301
    rs1851949241,2
    --171808659(+) CAGTTA/GGACAT 2 -- us2k10--------
    rs1901193201,2
    --171808675(+) ATGAAA/CAAGAT 2 -- us2k10--------
    rs1422844661,2
    --171808700(+) CTATCC/TGGATC 2 -- us2k10--------
    rs1821738581,2
    --171808731(+) CTCCTC/TTCCTT 2 -- us2k10--------
    rs10150081,2
    C,F,O,A,H--171808746(-) AAAGTA/GAAAAG 2 -- us2k123Minor allele frequency- G:0.24NA EA MN WA CSA 1115
    rs1856186391,2
    C--171808778(+) ACTTCC/TCTTCT 2 -- us2k10--------
    rs1882572341,2
    --171808823(+) TTATTC/TCTCAC 2 -- us2k10--------
    rs1808234981,2
    --171808912(+) CTCAAA/GTCAGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DNM3 (171810621 - 172060621 bp, first 250kb of DNM3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DNM3 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664393CNV Deletion23128226
    esv2670196CNV Deletion23128226
    esv2615149CNV Deletion19546169
    nsv3521CNV Insertion18451855
    esv275460CNV Loss21479260
    nsv465650CNV Loss19166990
    nsv3532CNV Loss18451855
    nsv3543CNV Loss18451855
    nsv508047CNV Loss20534489
    nsv872546CNV Loss21882294

    Human Gene Mutation Database (HGMD): DNM3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNM3
    DNA2.0 Custom Variant and Variant Library Synthesis for DNM3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611445    OMIM disorders: --

    1 disease for DNM3:    
    About MalaCards
    dominant optic atrophy


    Find genes that share disorders with DNM3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for DNM3 gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    optic atrophy autosomal dominant 51 1 17167772 (1)
    wiskott-aldrich syndrome 48.2 3 16540475 (1), 12686614 (1), 16418535 (1)
    cholera 36.4 5 9531551 (1), 15496455 (1), 15146065 (1), 19438805 (1) (see all 5)
    influenza 10.4 2 10648179 (2)
    diphtheria 5.65 6 9521846 (3), 15511085 (1), 10547351 (1)
    metastasis 5.06 1 16505488 (1)
    cancer 4.68 2 19857461 (2)
    melanoma 2.61 1 16306044 (1)
    leukemia 1.93 2 10816441 (1)
    tumors 0.721 3 11672786 (1), 12695554 (1), 12848341 (1)

    Genetic Association Database (GAD): DNM3
    Human Genome Epidemiology (HuGE) Navigator: DNM3 (4 documents)

    Export disorders for DNM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNM3 gene, integrated from 10 sources (see all 467):
    (articles sorted by number of sources associating them with DNM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    2. New gene functions in megakaryopoiesis and platelet formation. (PubMed id 22139419)1, 4 Gieger C....Soranzo N. (Nature 2011)
    3. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. (PubMed id 20935629)1, 4 Heid I.M....Lindgren C.M. (Nat. Genet. 2010)
    6. Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. (PubMed id 19266077)1, 4 Sovio U....Jarvelin M.R. (PLoS Genet. 2009)
    7. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. (PubMed id 19820697)1, 4 Soranzo N....Gieger C. (Nat. Genet. 2009)
    8. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    10. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26052 HGNC: 29125 AceView: DNM3 Ensembl:ENSG00000197959 euGenes: HUgn26052
    ECgene: DNM3 Kegg: 26052 H-InvDB: DNM3

    (According to HUGE)
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    HUGE: KIAA0820

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DNM3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DNM3 gene:
    Search GeneIP for patents involving DNM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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