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Aliases for DNM3 Gene

Aliases for DNM3 Gene

  • Dynamin 3 2 3 5
  • Dynamin, Testicular 3 4
  • EC 3.6.5.5 4 63
  • T-Dynamin 3 4
  • Dyna III 2 3
  • Dynamin Family Member 3
  • KIAA0820 4

External Ids for DNM3 Gene

Previous GeneCards Identifiers for DNM3 Gene

  • GC01P169051
  • GC01P168542
  • GC01P170077
  • GC01P143034

Summaries for DNM3 Gene

Entrez Gene Summary for DNM3 Gene

  • This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

GeneCards Summary for DNM3 Gene

DNM3 (Dynamin 3) is a Protein Coding gene. Diseases associated with DNM3 include Optic Atrophy 1. Among its related pathways are Bacterial invasion of epithelial cells and Synaptic vesicle cycle. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is MX1.

UniProtKB/Swiss-Prot for DNM3 Gene

  • Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity).

Tocris Summary for DNM3 Gene

  • GTPases are a group of enzymes that catalyze hydrolysis of the gamma phosphate bond in guanine triphosphate (GTP) to form guanine diphosphate (GDP). Mg2+ ions are essential for catalytic activity. GTPases, often coupled to G proteins, are essential in signal transduction.

Gene Wiki entry for DNM3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNM3 Gene

Genomics for DNM3 Gene

Regulatory Elements for DNM3 Gene

Enhancers for DNM3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DNM3 on UCSC Golden Path with GeneCards custom track

Promoters for DNM3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DNM3 on UCSC Golden Path with GeneCards custom track

Genomic Location for DNM3 Gene

Chromosome:
1
Start:
171,841,478 bp from pter
End:
172,418,466 bp from pter
Size:
576,989 bases
Orientation:
Plus strand

Genomic View for DNM3 Gene

Genes around DNM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNM3 Gene

Proteins for DNM3 Gene

  • Protein details for DNM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQ16-DYN3_HUMAN
    Recommended name:
    Dynamin-3
    Protein Accession:
    Q9UQ16
    Secondary Accessions:
    • A9Z1Y1
    • O14982
    • O95555
    • Q1MTM8
    • Q5W129
    • Q6P2G1
    • Q9H0P3
    • Q9H548
    • Q9NQ68
    • Q9NQN6

    Protein attributes for DNM3 Gene

    Size:
    869 amino acids
    Molecular mass:
    97746 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA74843.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DNM3 Gene

    Alternative splice isoforms for DNM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNM3 Gene

Proteomics data for DNM3 Gene at MOPED

Post-translational modifications for DNM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DNM3 Gene

Gene Families for DNM3 Gene

Suggested Antigen Peptide Sequences for DNM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UQ16

UniProtKB/Swiss-Prot:

DYN3_HUMAN :
  • Contains 1 dynamin-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
Domain:
  • Contains 1 dynamin-type G (guanine nucleotide-binding) domain.
  • Contains 1 GED domain.
  • Contains 1 PH domain.
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
genes like me logo Genes that share domains with DNM3: view

Function for DNM3 Gene

Molecular function for DNM3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
GTP + H(2)O = GDP + phosphate.
UniProtKB/Swiss-Prot Function:
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity).

Enzyme Numbers (IUBMB) for DNM3 Gene

Gene Ontology (GO) - Molecular Function for DNM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15252009
GO:0031802 type 5 metabotropic glutamate receptor binding IEA --
genes like me logo Genes that share ontologies with DNM3: view
genes like me logo Genes that share phenotypes with DNM3: view

Animal Models for DNM3 Gene

MGI Knock Outs for DNM3:

Animal Model Products

miRNA for DNM3 Gene

miRTarBase miRNAs that target DNM3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DNM3 Gene

Localization for DNM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNM3 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated. {ECO:0000305}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNM3 Gene COMPARTMENTS Subcellular localization image for DNM3 gene
Compartment Confidence
extracellular 5
cytoskeleton 4
cytosol 3
golgi apparatus 2
mitochondrion 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DNM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001917 photoreceptor inner segment IEA --
GO:0014069 postsynaptic density ISS --
GO:0030424 axon IEA --
GO:0043083 synaptic cleft IEA --
GO:0043197 dendritic spine ISS --
genes like me logo Genes that share ontologies with DNM3: view

Pathways & Interactions for DNM3 Gene

genes like me logo Genes that share pathways with DNM3: view

Interacting Proteins for DNM3 Gene

Gene Ontology (GO) - Biological Process for DNM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007416 synapse assembly ISS --
GO:0061002 negative regulation of dendritic spine morphogenesis IEA --
genes like me logo Genes that share ontologies with DNM3: view

No data available for SIGNOR curated interactions for DNM3 Gene

Drugs & Compounds for DNM3 Gene

(32) Drugs for DNM3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(37) Additional Compounds for DNM3 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
8-CPT-2Me-cAMP, sodium salt
634207-53-7
8-pCPT-2-O-Me-cAMP-AM
1152197-23-3
Dynamin inhibitory peptide
251634-21-6

(5) Tocris Compounds for DNM3 Gene

Compound Action Cas Number
8-CPT-2Me-cAMP, sodium salt Selective Epac activator 634207-53-7
8-pCPT-2-O-Me-cAMP-AM Selective Epac activator; cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645) 1152197-23-3
Dynamin inhibitory peptide Dynamin inhibitor 251634-21-6
Dynamin inhibitory peptide, myristoylated Cell-permeable dynamin inhibitor 251634-22-7
Dynamin inhibitory peptide, myristoylated (control) Control peptide version of dynamin inhibitory peptide, myristoylated (Cat. No. 1775)
genes like me logo Genes that share compounds with DNM3: view

Transcripts for DNM3 Gene

Unigene Clusters for DNM3 Gene

Dynamin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNM3 Gene

No ASD Table

Relevant External Links for DNM3 Gene

GeneLoc Exon Structure for
DNM3
ECgene alternative splicing isoforms for
DNM3

Expression for DNM3 Gene

mRNA expression in normal human tissues for DNM3 Gene

mRNA differential expression in normal tissues according to GTEx for DNM3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.4), Brain - Cerebellum (x4.5), and Brain - Frontal Cortex (BA9) (x4.2).

Protein differential expression in normal tissues from HIPED for DNM3 Gene

This gene is overexpressed in Brain (41.3), Frontal cortex (10.4), and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for DNM3 Gene



SOURCE GeneReport for Unigene cluster for DNM3 Gene Hs.654775

genes like me logo Genes that share expression patterns with DNM3: view

Protein tissue co-expression partners for DNM3 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for DNM3 Gene

Orthologs for DNM3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNM3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNM3 35
  • 91.68 (n)
  • 98.31 (a)
DNM3 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNM3 35
  • 91.27 (n)
  • 97.39 (a)
DNM3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnm3 35
  • 89.33 (n)
  • 97.9 (a)
Dnm3 16
Dnm3 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DNM3 35
  • 97.42 (n)
  • 97.18 (a)
DNM3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnm3 35
  • 88.94 (n)
  • 97.09 (a)
oppossum
(Monodelphis domestica)
Mammalia DNM3 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNM3 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNM3 35
  • 81.9 (n)
  • 92.12 (a)
DNM3 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 78 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dnm3 35
  • 73.98 (n)
  • 79.52 (a)
zebrafish
(Danio rerio)
Actinopterygii dnm2a 35
  • 72.94 (n)
  • 83.05 (a)
dnm3 36
  • 77 (a)
OneToOne
soybean
(Glycine max)
eudicotyledons Gma.4720 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10361 35
barley
(Hordeum vulgare)
Liliopsida Hv.2342 35
rice
(Oryza sativa)
Liliopsida Os.27352 35
wheat
(Triticum aestivum)
Liliopsida Ta.307 35
corn
(Zea mays)
Liliopsida Zm.5017 35
Species with no ortholog for DNM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for DNM3 Gene

ENSEMBL:
Gene Tree for DNM3 (if available)
TreeFam:
Gene Tree for DNM3 (if available)

Paralogs for DNM3 Gene

Paralogs for DNM3 Gene

(6) SIMAP similar genes for DNM3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DNM3: view

Variants for DNM3 Gene

Sequence variations from dbSNP and Humsavar for DNM3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs473629 -- 172,172,401(+) GGTGG(A/T)TAGCA intron-variant
rs477289 -- 172,222,254(+) ATCAT(A/C)AAGAA intron-variant
rs479185 -- 172,173,010(+) CAGGT(A/G)GTGAA intron-variant
rs479336 -- 172,230,433(+) ATATT(G/T)TTGTA intron-variant
rs479960 -- 172,182,532(+) AAAAT(G/T)TTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNM3 Gene

Variant ID Type Subtype PubMed ID
nsv831893 CNV Loss 17160897
nsv3521 CNV Insertion 18451855
esv2670196 CNV Deletion 23128226
esv2615149 CNV Deletion 19546169
esv275460 CNV Loss 21479260
nsv3532 CNV Loss 18451855
nsv508047 CNV Loss 20534489
nsv465650 CNV Loss 19166990
nsv872546 CNV Loss 21882294
esv2664393 CNV Deletion 23128226
nsv3543 CNV Loss 18451855

Variation tolerance for DNM3 Gene

Residual Variation Intolerance Score: 11.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNM3 Gene

Human Gene Mutation Database (HGMD)
DNM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNM3 Gene

Disorders for DNM3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DNM3 Gene - From: Novoseek

Disorder Aliases PubMed IDs
optic atrophy 1
  • optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy
- elite association - COSMIC cancer census association via MalaCards
Search DNM3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DNM3

Genetic Association Database (GAD)
DNM3
Human Genome Epidemiology (HuGE) Navigator
DNM3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNM3
genes like me logo Genes that share disorders with DNM3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNM3 Gene

Publications for DNM3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. A clathrin-dynamin-dependent endocytic pathway for the uptake of HIV-1 by direct T cell-T cell transmission. (PMID: 18602423) Bosch B. … Este J.A. (Antiviral Res. 2008) 3 23
  3. Dynamin 3 participates in the growth and development of megakaryocytes. (PMID: 19007685) Reems J.A. … Gilligan D.M. (Exp. Hematol. 2008) 3 23
  4. Dynamin: characteristics, mechanism of action and function. (PMID: 12511974) Wiejak J. … Wyroba E. (Cell. Mol. Biol. Lett. 2002) 3 23
  5. Genetic loci associated with circulating levels of very long-chain saturated fatty acids. (PMID: 25378659) Lemaitre R.N. … Friedlander Y. (J. Lipid Res. 2015) 3

Products for DNM3 Gene

Sources for DNM3 Gene

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