Aliases for DNM2 Gene
External Ids for DNM2 Gene
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]
GeneCards Summary for DNM2 Gene
DNM2 (Dynamin 2) is a Protein Coding gene. Diseases associated with DNM2 include charcot-marie-tooth disease, dominant intermediate b and lethal congenital contracture syndrome 5. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include GTP binding and protein kinase binding. An important paralog of this gene is MX1.
UniProtKB/Swiss-Prot for DNM2 Gene
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis.
Dynamin is a GTPase that is involved in endocytosis. GTPases are a group of enzymes that catalyze hydrolysis of the gamma phosphate bond in guanine triphosphate (GTP) to form guanine diphosphate (GDP). Mg2+ is essential for catalytic activity. GTPases are often coupled to G proteins and have essential roles in signal transduction, protein synthesis and translocation, control of cell growth and differentiation and vesicular transport regulation.