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DNM1 Gene

protein-coding   GIFtS: 71
GCID: GC09P130965

Dynamin 1


(Previous symbol: DNM)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dynamin 11 2
DNM1 2 3
EC 3.6.5.53 8
dynamin-12

External Ids:    HGNC: 29721   Entrez Gene: 17592   Ensembl: ENSG000001069767   OMIM: 6023775   UniProtKB: Q051933   

Export aliases for DNM1 gene to outside databases

Previous GC identifers: GC09P122080 GC09P122612 GC09P124419 GC09P126342 GC09P126343 GC09P128045 GC09P130005 GC09P100579


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNM1 Gene:
This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique
mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis
and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the
encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly
conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y
and 15. Alternatively spliced transcript variants encoding different isoforms have been described. (provided by
RefSeq, Jul 2008)

GeneCards Summary for DNM1 Gene:
DNM1 (dynamin 1) is a protein-coding gene. Diseases associated with DNM1 include pleural empyema, and neuronal intranuclear inclusion disease. GO annotations related to this gene include phospholipid binding and identical protein binding. An important paralog of this gene is MX2.

UniProtKB/Swiss-Prot: DYN1_HUMAN, Q05193
Function: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to
bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated
endocytosis

summary for DNM1 Gene:
Dynamin is a GTPase that is involved in endocytosis. GTPases are a group of enzymes that catalyze hydrolysis
of the gamma phosphate bond in guanine triphosphate (GTP) to form guanine diphosphate (GDP). Mg2+ is
essential for catalytic activity. GTPases are often coupled to G proteins and have essential roles in signal
transduction, protein synthesis and translocation, control of cell growth and differentiation and vesicular
transport regulation.

Gene Wiki entry for DNM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNM1 gene promoter:
         AP-2alpha isoform 3   AP-1   AP-2alpha isoform 2   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNM1 promoter sequence
   Search Chromatin IP Primers for DNM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34

DNM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNM1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P130965:  view genomic region     (about GC identifiers)

Start:
130,965,658 bp from pter      End:
131,017,527 bp from pter
Size:
51,870 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DYN1_HUMAN, Q05193 (See protein sequence)
Recommended Name: Dynamin-1  
Size: 864 amino acids; 97408 Da
Subunit: Interacts with CAV1 and SH3GLB1. Binds SH3GL1, SH3GL2 and SH3GL3 (By similarity). Interacts with PHOCN.
Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Interacts with SNX9. Interacts with MYO1E (via SH3
domain). Interacts with SNX33 (via SH3 domain)
Selected PDB 3D structures from and Proteopedia for DNM1 (see all 7):
1DYN (3D)        2DYN (3D)        2X2E (3D)        2X2F (3D)        3SNH (3D)        3ZYC (3D)    
Secondary accessions: A6NLM6 Q5SYX0 Q5SYX2 Q6P3T6 Q86VD2
Alternative splicing: 5 isoforms:  Q05193-1   Q05193-2   Q05193-3   Q05193-4   Q05193-5   

Explore the universe of human proteins at neXtProt for DNM1: NX_Q05193

Explore proteomics data for DNM1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys223
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DNM1 (Q05193) (see all 41)
     AEFLHCK  GVVNRSQ  TKLDLMD  GIMKGGS 


    See DNM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001005336.1  NP_001275666.1  NP_001275667.1  NP_001275668.1  NP_004399.2  

    ENSEMBL proteins: 
     ENSP00000419225   ENSP00000345680   ENSP00000362014   ENSP00000377219   ENSP00000420045  
     ENSP00000420808  
    Reactome Protein details: Q05193

    DNM1 Human Recombinant Protein Products:

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    OriGene Purified Protein for DNM1
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    OriGene Custom MassSpec
    OriGene Custom Protein Services for DNM1
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DNM1

    DNM1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of DNM1
    R&D Systems Antibodies for DNM1 (Dynamin)
    Cell Signaling Technology (CST) Antibodies for DNM1  (DYN1)
    OriGene Antibodies for DNM1
    OriGene Custom Antibody Services for DNM1
    Novus Biologicals DNM1 Antibodies
    Abcam antibodies for DNM1 (Q05193, P50570)
    Cloud-Clone Corp. Antibodies for DNM1
    ThermoFisher Antibodies for DNM1
    LSBio Antibodies in human, mouse, rat for DNM1

    DNM1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DNM1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DNM1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DNM1
    Cloud-Clone Corp. CLIAs for DNM1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    Selected InterPro protein domains (see all 10):
     IPR003130 GED
     IPR020850 GTPase_effector_domain_GED
     IPR001849 Pleckstrin_homology
     IPR022812 Dynamin_SF
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q05193

    ProtoNet protein and cluster: Q05193

    2 Blocks protein domains:
    IPB001401 Dynamin
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: DYN1_HUMAN, Q05193
    Similarity: Belongs to the dynamin family
    Similarity: Contains 1 GED domain
    Similarity: Contains 1 PH domain


    DNM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DYN1_HUMAN, Q05193
    Function: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to
    bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated
    endocytosis
    Catalytic activity: GTP + H(2)O = GDP + phosphate

         Genatlas biochemistry entry for DNM1:
    dynamin 1,100kDa,GTP binding protein,expressed in the brain,involved in early stage of clathrin-mediated
    endocytosis and formation of synaptic vesicles

         Enzyme Number (IUBMB): EC 3.6.5.51 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding IPI10206341
    GO:0005525GTP binding IEA--
    GO:0008022protein C-terminus binding IEA--
    GO:0032403protein complex binding IEA--
         
    DNM1 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dnm1):
     behavior/neurological  cellular  hearing/vestibular/ear  homeostasis/metabolism  mortality/aging 
     nervous system  normal 

    DNM1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dnm1tm1Pdc for DNM1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNM1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DNM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DNM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DNM1

    miRNA
    Products:
        
    miRTarBase miRNAs that target DNM1:
    hsa-mir-615-3p (MIRT039910)

    Block miRNA regulation of human, mouse, rat DNM1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate DNM1:
    hsa-miR-140-3p hsa-miR-224 hsa-miR-3065-3p hsa-miR-589* hsa-miR-3145-3p hsa-miR-3179 hsa-miR-4260
    SwitchGear 3'UTR luciferase reporter plasmidDNM1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DNM1
    Predesigned siRNA for gene silencing in human, mouse, rat DNM1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DNM1

    Clone
    Products:
         
    OriGene clones in human, mouse for DNM1 (see all 14)
    OriGene ORF clones in mouse, rat for DNM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DNM1 (NM_004408)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNM1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for DNM1
    Browse ESI BIO Cell Lines and PureStem Progenitors for DNM1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DYN1_HUMAN, Q05193: Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    endosome2
    mitochondrion2
    plasma membrane2
    extracellular1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005874microtubule IEA--
    GO:0030117membrane coat IEA--
    GO:0043234protein complex ----

    DNM1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DNM1 About   (see all 26)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Endocytic Trafficking of EGFR
    Endocytic Trafficking of EGFR0.36
    Recycling pathway of L10.33
    Retrograde neurotrophin signalling0.36
    2Synaptic vesicle cycle
    Synaptic Vesicle Pathway0.50
    Synaptic vesicle cycle0.50
    3Gap junction trafficking
    Gap junction trafficking0.93
    Formation of annular gap junctions0.00
    Gap junction trafficking and regulation0.93
    Gap junction degradation0.00
    4L1CAM interactions
    Axon guidance0.63
    L1CAM interactions0.36
    Developmental Biology0.63
    5Signaling by FGFR
    NGF signalling via TRKA from the plasma membrane0.71
    Signalling by NGF0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for DNM1
        Notch Signaling Pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for DNM1
        Endocytic Trafficking of EGFR
    Remodeling of Adherens Junctions
    GnRH Signaling

    1 Cell Signaling Technology (CST) Pathway for DNM1
        Cytoskeletal Signaling

    Selected BioSystems Pathways for DNM1 (see all 11)
        EGFR1 Signaling Pathway
    IL-3 Signaling Pathway
    Synaptic Vesicle Pathway
    Neurotrophic factor-mediated Trk receptor signaling
    Internalization of ErbB1

    Selected Reactome Pathways for DNM1 (see all 6)
        Recycling pathway of L1
    Gap junction degradation
    Toll Like Receptor 4 (TLR4) Cascade
    Formation of annular gap junctions
    Retrograde neurotrophin signalling


    4 Kegg Pathways  (Kegg details for DNM1):
        Endocytosis
    Synaptic vesicle cycle
    Endocrine and other factor-regulated calcium reabsorption
    Bacterial invasion of epithelial cells


    DNM1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNM1: 
              Adherens Junctions in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DNM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNM1 (Q051931, 2, 3 ENSP000003620144) via UniProtKB, MINT, STRING, and/or I2D (see all 177)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629931, 2, 3, ENSP000003390074EBI-713135,EBI-401755 MINT-65952 MINT-65951 I2D: score=7 STRING: ENSP00000339007
    AMPHP494182, 3, ENSP000003486024MINT-18828 MINT-8096359 MINT-18829 MINT-65945 MINT-8096278 MINT-8096384 I2D: score=7 STRING: ENSP00000348602
    ITSN1Q158112, 3, ENSP000003707194MINT-65948 MINT-65947 MINT-7302450 I2D: score=5 STRING: ENSP00000370719
    SNX9Q9Y5X12, 3, ENSP000003760244MINT-61333 MINT-62868 MINT-61330 I2D: score=2 STRING: ENSP00000376024
    NOSTRINQ8IVI91, 2, ENSP000003189214EBI-713135,EBI-1391643 MINT-7213470 MINT-7213417 MINT-7213439 STRING: ENSP00000318921
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS10944110
    GO:0006897endocytosis IMP19706678
    GO:0006898receptor-mediated endocytosis IMP10521508
    GO:0007032endosome organization IMP19706678
    GO:0031623receptor internalization IEA--

    DNM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for DNM1
      Browse compounds at ApexBio 

    Compounds for DNM1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    HJC 0350Selective Epac2 inhibitor[885434-70-8]
    Dynamin inhibitory peptide, myristoylated (control) Control peptide version of dynamin inhibitory peptide, myristoylated (Cat. No. 1775) --
    8CPT-2Me-cAMP, sodium salt Selective Epac activator[510774-50-2]
    DynasoreNon-competitive dynamin inhibitor[304448-55-3]
    ML 141Selective inhibitor of Cdc42 Rho family GTPase[71203-35-5]

    4 HMDB Compounds for DNM1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    5 Novoseek inferred chemical compound relationships for DNM1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphoinositide 46.8 2 11160859 (1), 9765310 (1)
    gtp 35.8 4 10559861 (1), 10074457 (1), 15954862 (1)
    phosphatidylinositol 15.8 1 18266936 (1)
    lipid 0 1 19776347 (1)
    calcium 0 3 16864575 (2), 10473536 (1)



    DNM1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for DNM1 gene (5 alternative transcripts): 
    NM_001005336.2  NM_001288737.1  NM_001288738.1  NM_001288739.1  NM_004408.3  

    Unigene Cluster for DNM1:

    Dynamin 1
    Hs.522413  [show with all ESTs]
    Unigene Representative Sequence: AK127038
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475805(uc022bnx.1) ENST00000341179(uc022bny.1 uc022bnz.1)
    ENST00000372923(uc022boa.1 uc022bob.1) ENST00000393594(uc004buc.1)
    ENST00000486160 ENST00000441149(uc004bub.1) ENST00000482638 ENST00000463998
    ENST00000479174 ENST00000493925

    miRNA
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    Block miRNA regulation of human, mouse, rat DNM1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate DNM1:
    hsa-miR-140-3p hsa-miR-224 hsa-miR-3065-3p hsa-miR-589* hsa-miR-3145-3p hsa-miR-3179 hsa-miR-4260
    SwitchGear 3'UTR luciferase reporter plasmidDNM1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DNM1
    Predesigned siRNA for gene silencing in human, mouse, rat DNM1
    Clone
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    OriGene clones in human, mouse for DNM1 (see all 14)
    OriGene ORF clones in mouse, rat for DNM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DNM1 (NM_004408)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNM1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DNM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNM1
      QuantiTect SYBR Green Assays in human, mouse, rat DNM1
      QuantiFast Probe-based Assays in human, mouse, rat DNM1

    Additional mRNA sequence: 

    AF035321.1 AK127038.1 AK225179.1 AK295101.1 AK296326.1 AK308793.1 AK316235.1 BC050279.1 
    BC063850.1 L07807.1 L07808.1 L07809.1 L07810.1 

    14 DOTS entries:

    DT.100783547  DT.100025770  DT.40234572  DT.115646  DT.91747199  DT.75118572  DT.92377159  DT.121189880 
    DT.91748737  DT.95346782  DT.100000367  DT.101975761  DT.92005726  DT.121189853 

    Selected AceView cDNA sequences (see all 138):

    BQ888183 BQ961890 BQ888167 BQ882122 BU149199 CR592374 BU073243 BX463619 
    T28122 BE048201 BE699859 BM826534 BP360632 AA323959 L07808 BQ581673 
    BC063850 T12613 AU153788 AL157631 AL538642 D51892 BI913558 AA323355 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNM1 expression in normal human tissues (normalized intensities)      DNM1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGTGCTGT
    DNM1 Expression
    About this image


    DNM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Bone (Muscoskeletal System)
             Mandibular Condyle
    DNM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522413
        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNM1: 
              Adherens Junctions in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DNM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNM1
    QuantiTect SYBR Green Assays in human, mouse, rat DNM1
    QuantiFast Probe-based Assays in human, mouse, rat DNM1
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNM1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnm11 , 5 dynamin 11, 5 90.94(n)1
    97.64(a)1
      2 (22.09 cM)5
    134291  NM_010065.21  NP_034195.21 
     323084715 
    chicken
    (Gallus gallus)
    Aves DNM11 dynamin 1 82.45(n)
    93.63(a)
      417217  XM_001233249.3  XP_001233250.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia BX853705.12   -- 82.05(n)    BX853705.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dnm1b1 dynamin 1b 76.64(n)
    87.38(a)
      100333543  NM_001256818.1  NP_001243747.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta shi1 , 3 cellularization actin binding3
    shibire1
    68(a)3
    65.89(n)1
    71.43(a)1
      1 13F183
    459281  NM_001169296.11  NP_001162767.11 
    worm
    (Caenorhabditis elegans)
    Secernentea dyn-11 , 3 dynamin3
    dyn-11
    67(a)3
    62.44(n)1
    66.26(a)1
      X(15604145-15608173)3
    1816441  NM_001029161.21  NP_001024332.11 
    rice
    (Oryza sativa)
    Liliopsida Os.190792 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 71.26(n)    AK073965.1 


    ENSEMBL Gene Tree for DNM1 (if available)
    TreeFam Gene Tree for DNM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNM1 gene
    MX22  DNM22  DNM1L2  DNM32  MX12  
    5 SIMAP similar genes for DNM1 using alignment to 2 protein entries:     DYN1_HUMAN (see all proteins):
    DNM3    DNM2    DNM1P34    DNM1L    MX2

    DNM1 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for DNM1 (see all 25)
    PGOHUM00000261091 PGOHUM00000261166 PGOHUM00000261167 PGOHUM00000261168 PGOHUM00000261173


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNM1 (see all 1109)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs352079501,2
    C--100586691(+) AAAAA-/AGTAAT 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs3694641401,2
    C--100602745(+) CATTC-/TTTTTT 2 -- int10--------
    rs109879261,2
    C--130976270(+) CTCCAA/GCCTGG 2 -- us2k10--------
    rs1922589421,2
    --130976564(+) CCCCTA/GAGCAC 2 -- us2k10--------
    rs109879271,2
    C,F,H--130976673(+) acgcaG/Acttgt 2 -- us2k120Minor allele frequency- A:0.03NS EA NA WA CSA 1849
    rs1828730301,2
    --130976742(+) TTGTTC/TCCCAT 2 -- us2k10--------
    rs1871972051,2
    --130976764(+) AGATTC/TCTCCC 2 -- us2k10--------
    rs1478914071,2
    --130976823(+) TACCCC/GGCCCC 2 -- us2k10--------
    rs1416373571,2
    --130976870(+) GCCATA/CGTTAT 2 -- us2k10--------
    rs1165081631,2
    F--130977078(+) CACAGC/TGCAGG 2 -- us2k11Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for DNM1 (130965658 - 131017527 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DNM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831728CNV Loss17160897
    dgv8294n71CNV Loss21882294
    nsv893896CNV Loss21882294
    nsv893891CNV Loss21882294
    nsv893859CNV Loss21882294

    Human Gene Mutation Database (HGMD): DNM1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNM1
    DNA2.0 Custom Variant and Variant Library Synthesis for DNM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602377    OMIM disorders: --

    Selected diseases for DNM1 (see all 22):    About MalaCards
    pleural empyema    neuronal intranuclear inclusion disease    dominant optic atrophy    vesiculitis
    pericarditis    rett syndrome    optic atrophy    nicotine dependence
    mediastinitis    wiskott-aldrich syndrome    gout    down syndrome
    herpes simplex    cystic fibrosis    influenza    schizophrenia
    alzheimer's disease    hiv-1    neuronitis    pancreatitis


    DNM1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for DNM1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurodegeneration 28.2 1 16864575 (1)
    senile plaques 19.7 1 16864575 (1)

    Genetic Association Database (GAD): DNM1
    Human Genome Epidemiology (HuGE) Navigator: DNM1 (1 document)

    Export disorders for DNM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNM1 gene, integrated from 10 sources (see all 191):
    (articles sorted by number of sources associating them with DNM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the dynamin-1 gene (DNM1) to human chromosome 9q34 by fluorescence in situ hybridization and somatic cell hybrid analysis. (PubMed id 9143509)1, 3, 9 Newman-Smith E.D....van der Bliek A.M. (Genomics 1997)
    2. Detection of genetic association and a functional polymorphism of dynamin 1 gene with nicotine dependence in European and African Americans. (PubMed id 18987626)1, 4, 9 Xu Q....Li M.D. (Neuropsychopharmacology 2009)
    3. SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis. (PubMed id 15703209)1, 2, 9 Soulet F.... Schmid S.L. (Mol. Biol. Cell 2005)
    4. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PubMed id 18839057)1, 4 Lesch K.P....Jacob C. (J Neural Transm 2008)
    5. Crystal structure of the pleckstrin homology domain from dynamin. (PubMed id 7634088)1, 2 Timm D.... Blundell T. (Nat. Struct. Biol. 1994)
    6. Crystal structure at 2.2-A resolution of the pleckstrin homology domain from human dynamin. (PubMed id 7954789)1, 2 Ferguson K.M.... Sigler P.B. (Cell 1994)
    7. Three-dimensional solution structure of the pleckstrin homology domain from dynamin. (PubMed id 7850421)1, 2 Downing A.K....Waterfield M.D. (Curr. Biol. 1994)
    8. Mutations in human dynamin block an intermediate stage in coated vesicle formation. (PubMed id 8101525)1, 2 van der Bliek A.M....Schmid S.L. (J. Cell Biol. 1993)
    9. Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTP-binding proteins. (PubMed id 2144893)1, 3 Obar R.A....Vallee R.B. (Nature 1990)
    10. Mnb/Dyrk1A phosphorylation regulates the interaction of dynamin 1 with SH3 domain-containing proteins. (PubMed id 15287745)1, 9 Huang Y....Hwang Y.W. (Biochemistry 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1759 HGNC: 2972 AceView: DNM1 Ensembl:ENSG00000106976 euGenes: HUgn1759
    ECgene: DNM1 Kegg: 1759 H-InvDB: DNM1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DNM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DNM1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNM1 gene:
    Search GeneIP for patents involving DNM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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