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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DNM1 Gene

protein-coding   GIFtS: 70
GCID: GC09P130965

Dynamin 1


(Previous symbol: DNM)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dynamin 11 2
DNM1 2 3
EC 3.6.5.53 8
dynamin-12

External Ids:    HGNC: 29721   Entrez Gene: 17592   Ensembl: ENSG000001069767   OMIM: 6023775   UniProtKB: Q051933   

Export aliases for DNM1 gene to outside databases

Previous GC identifers: GC09P122080 GC09P122612 GC09P124419 GC09P126342 GC09P126343 GC09P128045 GC09P130005 GC09P100579


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DNM1 Gene:
This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique
mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis
and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the
encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly
conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y
and 15. Alternatively spliced transcript variants encoding different isoforms have been described. (provided by
RefSeq, Jul 2008)

GeneCards Summary for DNM1 Gene: 
DNM1 (dynamin 1) is a protein-coding gene. Diseases associated with DNM1 include pleural empyema, and neuronal intranuclear inclusion disease, and among its related super-pathways are Synaptic Vesicle Pathway and Retrograde neurotrophin signalling. GO annotations related to this gene include phospholipid binding and GTP binding. An important paralog of this gene is MX2.

UniProtKB/Swiss-Prot: DYN1_HUMAN, Q05193
Function: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to
bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated
endocytosis

summary for DNM1 Gene:
Dynamin is a GTPase that is involved in endocytosis. GTPases are a group of enzymes that catalyze hydrolysis
of the gamma phosphate bond in guanine triphosphate (GTP) to form guanine diphosphate (GDP). Mg2+ is
essential for catalytic activity. GTPases are often coupled to G proteins and have essential roles in signal
transduction, protein synthesis and translocation, control of cell growth and differentiation and vesicular
transport regulation.

Gene Wiki entry for DNM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DNM1 gene promoter:
         AP-2alpha isoform 3   AP-1   AP-2alpha isoform 2   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNM1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DNM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34

DNM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNM1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P130965:  view genomic region     (about GC identifiers)

Start:
130,965,658 bp from pter      End:
131,017,527 bp from pter
Size:
51,870 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DYN1_HUMAN, Q05193 (See protein sequence)
Recommended Name: Dynamin-1  
Size: 864 amino acids; 97408 Da
Subunit: Interacts with CAV1 and SH3GLB1. Binds SH3GL1, SH3GL2 and SH3GL3 (By similarity). Interacts with PHOCN.
Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Interacts with SNX9. Interacts with MYO1E (via SH3
domain)
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated
6/7 PDB 3D structures from and Proteopedia for DNM1 (see all 7):
1DYN (3D)        2DYN (3D)        2X2E (3D)        2X2F (3D)        3SNH (3D)        3ZYC (3D)    
Secondary accessions: A6NLM6 Q5SYX0 Q5SYX2 Q6P3T6 Q86VD2
Alternative splicing: 5 isoforms:  Q05193-1   Q05193-2   Q05193-3   Q05193-4   Q05193-5   

Explore the universe of human proteins at neXtProt for DNM1: NX_Q05193

Explore proteomics data for DNM1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q05193

  • 4/41 DME Specific Peptides for DNM1 (Q05193) (see all 41)
     AEFLHCK  GVVNRSQ  TKLDLMD  GIMKGGS 

    DNM1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DNM1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001005336.1  NP_004399.2  

    ENSEMBL proteins: 
     ENSP00000419225   ENSP00000345680   ENSP00000362014   ENSP00000377219   ENSP00000420045  
     ENSP00000420808  
    Reactome Protein details: Q05193
    Human Recombinant Protein Products for DNM1: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DNM1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005874microtubule IEA--
    GO:0030117membrane coat IEA--
    GO:0043234protein complex ----

    DNM1 for ontologies           About GeneDecksing



    DNM1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of DNM1
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    Abcam antibodies for DNM1
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    ThermoFisher Antibodies for DNM1
    LSBio Antibodies in human, mouse, rat for DNM1 

    Assay Products for DNM1: 
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    GenScript Custom Assay Services for DNM1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DNM1 
    Cloud-Clone Corp. CLIAs for DNM1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing

    5/9 InterPro protein domains (see all 9):
     IPR022812 Dynamin
     IPR003130 GED
     IPR011993 PH_like_dom
     IPR001401 Dynamin_GTPase
     IPR019762 Dynamin_GTPase_CS

    Graphical View of Domain Structure for InterPro Entry Q05193

    ProtoNet protein and cluster: Q05193

    2 Blocks protein domains:
    IPB001401 Dynamin
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: DYN1_HUMAN, Q05193
    Similarity: Belongs to the dynamin family
    Similarity: Contains 1 GED domain
    Similarity: Contains 1 PH domain


    DNM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DYN1_HUMAN, Q05193
    Function: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to
    bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated
    endocytosis
    Catalytic activity: GTP + H(2)O = GDP + phosphate

         Genatlas biochemistry entry for DNM1:
    dynamin 1,100kDa,GTP binding protein,expressed in the brain,involved in early stage of clathrin-mediated
    endocytosis and formation of synaptic vesicles

         Enzyme Number (IUBMB): EC 3.6.5.51 2

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding IPI10206341
    GO:0005525GTP binding IEA--
    GO:0005543phospholipid binding IEA--
    GO:0008022protein C-terminus binding IEA--
         
    DNM1 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dnm1):
     behavior/neurological  cellular  hearing/vestibular/ear  homeostasis/metabolism  mortality/aging 
     nervous system  normal 

    DNM1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dnm1tm1Pdc for DNM1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DNM1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DNM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DNM1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DNM1 

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate DNM1:
    hsa-miR-140-3p hsa-miR-224 hsa-miR-3065-3p hsa-miR-589* hsa-miR-3145-3p hsa-miR-3179 hsa-miR-4260
    SwitchGear 3'UTR luciferase reporter plasmidDNM1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): DNM1 (NM_004408)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNM1
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                         Customized lentivirus expression plasmids for stable overexpression of DNM1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNM1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DNM1 About   (see all 27)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Synaptic vesicle cycle
    Synaptic vesicle cycle0.50
    Synaptic Vesicle Pathway0.50
    2Endocytic Trafficking of EGFR
    Endocytic Trafficking of EGFR0.36
    Retrograde neurotrophin signalling0.36
    3Axon guidance
    Axon guidance0.69
    L1CAM interactions0.39
    Developmental Biology0.69
    Recycling pathway of L10.38
    4Formation of annular gap junctions
    Formation of annular gap junctions0.92
    Gap junction degradation0.92
    5Gap junction trafficking
    Gap junction trafficking0.74
    Gap junction trafficking and regulation0.70

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for DNM1
        Notch Signaling Pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DNM1
        Endocytic Trafficking of EGFR
    Remodeling of Adherens Junctions
    GnRH Signaling

    1 Cell Signaling Technology (CST) Pathway for DNM1
        Cytoskeletal Signaling

    5/11 BioSystems Pathways for DNM1 (see all 11)
        EGFR1 Signaling Pathway
    IL-3 Signaling Pathway
    Synaptic Vesicle Pathway
    CXCR3-mediated signaling events
    Ephrin B reverse signaling

    5/16        Reactome Pathways for DNM1 (see all 16)
        L1CAM interactions
    Developmental Biology
    Membrane Trafficking
    Formation of annular gap junctions
    Retrograde neurotrophin signalling


    4         Kegg Pathways  (Kegg details for DNM1):
        Endocytosis
    Synaptic vesicle cycle
    Endocrine and other factor-regulated calcium reabsorption
    Bacterial invasion of epithelial cells


    DNM1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DNM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/128 Interacting proteins for DNM1 (Q051931, 2, 3 ENSP000003620144) via UniProtKB, MINT, STRING, and/or I2D (see all 128)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629931, 2, 3, ENSP000003390074EBI-713135,EBI-401755 MINT-65952 MINT-65951 I2D: score=7 STRING: ENSP00000339007
    AMPHP494182, 3, ENSP000003486024MINT-18828 MINT-8096359 MINT-18829 MINT-65945 MINT-8096278 MINT-8096384 I2D: score=7 STRING: ENSP00000348602
    ITSN1Q158112, 3, ENSP000003707194MINT-65948 MINT-65947 MINT-7302450 I2D: score=5 STRING: ENSP00000370719
    SNX9Q9Y5X12, 3, ENSP000003760244MINT-61333 MINT-62868 MINT-61330 I2D: score=2 STRING: ENSP00000376024
    SH3GL1Q999612, 3, ENSP000002698864MINT-8096329 MINT-8096409 I2D: score=5 STRING: ENSP00000269886
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS10944110
    GO:0006897endocytosis IMP19706678
    GO:0006898receptor-mediated endocytosis IMP10521508
    GO:0007032endosome organization IMP19706678
    GO:0031623receptor internalization IEA--

    DNM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DNM1 for compounds           About GeneDecksing

    EMD Millipore small molecules for DNM1:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for DNM1

    Compounds for DNM1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    HJC 0350Selective Epac2 inhibitor[885434-70-8]
    Dynamin inhibitory peptide, myristoylated (control) Control peptide version of dynamin inhibitory peptide, myristoylated (Cat. No. 1775) --
    8CPT-2Me-cAMP, sodium salt Selective Epac activator[510774-50-2]
    DynasoreNon-competitive dynamin inhibitor[304448-55-3]
    ML 141Selective inhibitor of Cdc42 Rho family GTPase[71203-35-5]

    4 HMDB Compounds for DNM1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    5 Novoseek inferred chemical compound relationships for DNM1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphoinositide 46.8 2 11160859 (1), 9765310 (1)
    gtp 35.8 4 10559861 (1), 10074457 (1), 15954862 (1)
    phosphatidylinositol 15.8 1 18266936 (1)
    lipid 0 1 19776347 (1)
    calcium 0 3 16864575 (2), 10473536 (1)

    Search CenterWatch for drugs/clinical trials and news about DNM1 / DYN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DNM1 gene (2 alternative transcripts): 
    NM_001005336.1  NM_004408.2  

    Unigene Cluster for DNM1:

    Dynamin 1
    Hs.522413  [show with all ESTs]
    Unigene Representative Sequence: AK127038
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475805(uc022bnx.1) ENST00000341179(uc022bny.1 uc022bnz.1)
    ENST00000372923(uc022boa.1 uc022bob.1) ENST00000393594(uc004buc.1)
    ENST00000486160 ENST00000441149(uc004bub.1) ENST00000482638 ENST00000463998
    ENST00000479174 ENST00000493925

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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNM1

    Additional mRNA sequence: 

    AF035321.1 AK127038.1 AK225179.1 AK295101.1 AK296326.1 AK308793.1 AK316235.1 BC050279.1 
    BC063850.1 L07807.1 L07808.1 L07809.1 L07810.1 

    14 DOTS entries:

    DT.100783547  DT.100025770  DT.40234572  DT.115646  DT.91747199  DT.75118572  DT.92377159  DT.121189880 
    DT.91748737  DT.95346782  DT.100000367  DT.101975761  DT.92005726  DT.121189853 

    24/138 AceView cDNA sequences (see all 138):

    BQ581673 T12613 BC063850 L07808 CR592374 BQ961890 BP360632 BE699859 
    BM826534 BE048201 BU073243 T28122 BQ882122 AU153788 BQ888167 AA323959 
    BX463619 BU149199 BQ888183 BE699755 CD618676 BP348512 L07807 L07809 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DNM1 expression in normal human tissues (normalized intensities)      DNM1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGTGCTGT
    DNM1 Expression
    About this image


    DNM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Thalamus
             Globus Pallidus   
     
     Colon (Gastrointestinal Tract)
             colon ; peripheral nerve/ganglion   
     
     Peripheral Nervous System (Nervous System)
             colon ; peripheral nerve/ganglion   
     
     Bone (Muscoskeletal System)
             Mandibular Condyle
     
     Fibroblast
             Human Dermal Fibroblasts-neonate (HDF-n)   

    See DNM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DNM1

    SOURCE GeneReport for Unigene cluster: Hs.522413
        SABiosciences Expression via Pathway-Focused PCR Arrays including DNM1: 
              Adherens Junctions in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNM1 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnm11 , 5 dynamin 11, 5 91.74(n)1
    99.07(a)1
      2 (22.09 cM)5
    134291  NM_010065.21  NP_034195.21 
     323084715 
    chicken
    (Gallus gallus)
    Aves DNM11 dynamin 1 83.99(n)
    96.3(a)
      417217  XM_001233249.2  XP_001233250.1 
    lizard
    (Anolis carolinensis)
    Reptilia DNM16
    Uncharacterized protein
    89(a)
    1 ↔ 1
    GL343763.1(60422-172086)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX853705.12   -- 82.05(n)    BX853705.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dnm1b1 dynamin 1b 77.8(n)
    89.14(a)
      100333543  XM_002662179.2  XP_002662225.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta shi1 , 3 cellularization actin binding3
    shibire1
    68(a)3
    64.67(n)1
    70.71(a)1
      1 13F183
    459281  NM_001169296.11  NP_001162767.11 
    worm
    (Caenorhabditis elegans)
    Secernentea dyn-11 , 3 dynamin3
    Protein DYN-11
    67(a)3
    61.77(n)1
    65.25(a)1
      X(15604145-15608173)3
    1816441  NM_001029161.11  NP_001024332.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MGM1(YOR211C)4 Mitochondrial GTPase, present in complex with Ugo1p more   --   15(741569-738924) 854386  NP_014854.2 
    rice
    (Oryza sativa)
    Liliopsida Os.190792 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 71.26(n)    AK073965.1 


    ENSEMBL Gene Tree for DNM1 (if available)
    TreeFam Gene Tree for DNM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DNM1 gene
    MX22  DNM22  DNM32  MX12  
    5 SIMAP similar genes for DNM1 using alignment to 2 protein entries:     DYN1_HUMAN (see all proteins):
    DNM3    DNM1P34    DNM2    DNM1L    MX2

    DNM1 for paralogs           About GeneDecksing


    5/25 Pseudogenes.org Pseudogenes for DNM1 (see all 25)
    PGOHUM00000261091 PGOHUM00000261166 PGOHUM00000261167 PGOHUM00000261168 PGOHUM00000261173


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1109 SNPs in DNM1 are shown (see all 1109)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs352079501,2
    C--100586691(+) AAAAA-/AGTAAT 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs3694641401,2
    C--100602745(+) CATTC-/TTTTTT 2 -- int10--------
    rs109879261,2
    C--130976270(+) CTCCAA/GCCTGG 2 -- us2k10--------
    rs1922589421,2
    --130976564(+) CCCCTA/GAGCAC 2 -- us2k10--------
    rs109879271,2
    C,F,H--130976673(+) acgcaG/Acttgt 2 -- us2k120Minor allele frequency- A:0.03NS EA NA WA CSA 1849
    rs1828730301,2
    --130976742(+) TTGTTC/TCCCAT 2 -- us2k10--------
    rs1871972051,2
    --130976764(+) AGATTC/TCTCCC 2 -- us2k10--------
    rs1478914071,2
    --130976823(+) TACCCC/GGCCCC 2 -- us2k10--------
    rs1416373571,2
    --130976870(+) GCCATA/CGTTAT 2 -- us2k10--------
    rs1165081631,2
    F--130977078(+) CACAGC/TGCAGG 2 -- us2k11Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for DNM1 (130965658 - 131017527 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DNM1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831728CNV Loss17160897
    dgv8294n71CNV Loss21882294
    nsv893896CNV Loss21882294
    nsv893891CNV Loss21882294
    nsv893859CNV Loss21882294


    Human Gene Mutation Database (HGMD): DNM1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602377    OMIM disorders: --

    18 diseases for DNM1:    About MalaCards
    pleural empyema    neuronal intranuclear inclusion disease    vesiculitis    pericarditis
    nicotine dependence    rett syndrome    optic atrophy    mediastinitis
    wiskott-aldrich syndrome    gout    down syndrome    herpes simplex
    cystic fibrosis    influenza    schizophrenia    alzheimer's disease
    neuronitis    pancreatitis


    DNM1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for DNM1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurodegeneration 28.2 1 16864575 (1)
    senile plaques 19.7 1 16864575 (1)

    Genetic Association Database (GAD): DNM1
    Human Genome Epidemiology (HuGE) Navigator: DNM1 (1 document)

    Export disorders for DNM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DNM1 gene, integrated from 9 sources (see all 188):
    (articles sorted by number of sources associating them with DNM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the dynamin-1 gene (DNM1) to human chromosome 9q34 by fluorescence in situ hybridization and somatic cell hybrid analysis. (PubMed id 9143509)1, 3, 9 Newman-Smith E.D....van der Bliek A.M. (1997)
    2. Detection of Genetic Association and a Functional Polymorphism of Dynamin 1 Gene with Nicotine Dependence in European and African Americans. (PubMed id 18987626)1, 4, 9 Xu Q....Li M.D. (2008)
    3. SNX9 regulates dynamin assembly and is required for e fficient clathrin-mediated endocytosis. (PubMed id 15703209)1, 2, 9 Soulet F....Schmid S.L. (2005)
    4. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PubMed id 18839057)1, 4 Lesch K.P....Jacob C. (2008)
    5. Crystal structure of the pleckstrin homology domain from dynamin. (PubMed id 7634088)1, 2 Timm D.... Blundell T. (1994)
    6. Crystal structure at 2.2-A resolution of the pleckstrin homology domain from human dynamin. (PubMed id 7954789)1, 2 Ferguson K.M.... Sigler P.B. (1994)
    7. Three-dimensional solution structure of the pleckstrin homology domain from dynamin. (PubMed id 7850421)1, 2 Downing A.K....Waterfield M.D. (1994)
    8. Mutations in human dynamin block an intermediate stage in coated vesicle formation. (PubMed id 8101525)1, 2 van der Bliek A.M....Schmid S.L. (1993)
    9. Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTP-binding proteins. (PubMed id 2144893)1, 3 Obar R.A....Vallee R.B. (1990)
    10. Mnb/Dyrk1A phosphorylation regulates the interaction of dynamin 1 with SH3 domain-containing proteins. (PubMed id 15287745)1, 9 Huang Y....Hwang Y.W. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1759 HGNC: 2972 AceView: DNM1 Ensembl:ENSG00000106976 euGenes: HUgn1759
    ECgene: DNM1 Kegg: 1759 H-InvDB: DNM1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DNM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DNM1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DNM1 gene:
    Search GeneIP for patents involving DNM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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