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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DNM1 Gene

protein-coding   GIFtS: 68
GCID: GC09P130965

dynamin 1


(Previous symbol: DNM)
 Explore 23 diseases affiliated with
DNM1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DNM1    

Aliases
for DNM1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dynamin 11 2
DNM1 2 3
EC 3.6.5.53 8
Dynamin-11

External Ids:    HGNC: 29721   Entrez Gene: 17592   Ensembl: ENSG000001069767   OMIM: 6023775   UniProtKB: Q051933   

Export aliases for DNM1 gene to outside databases

Previous GC identifers: GC09P122080 GC09P122612 GC09P124419 GC09P126342 GC09P126343 GC09P128045 GC09P130005 GC09P100579


Summaries
for DNM1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DNM1:
This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique
mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and
other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded
protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved
copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15.
Alternatively spliced transcript variants encoding different isoforms have been described. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: DYN1_HUMAN, Q05193
Function: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and
hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis

summary for DNM1:
Dynamin is a GTPase that is involved in endocytosis. GTPases are a group of enzymes that catalyze hydrolysis
of the ? phosphate bond in guanine triphosphate (GTP) to form guanine diphosphate (GDP). Mg2+ is essential
for catalytic activity. GTPases are often coupled to G proteins and have essential roles in signal
transduction, protein synthesis and translocation, control of cell growth and differentiation and vesicular
transport regulation. There are six main groups of GTPases; heterotrimeric G protein GTPases (E.C. 3.6.5.1),
small monomeric GTPases (E.C. 3.6.5.2), protein-synthesizing GTPases (E.C. 3.6.5.3),
signal-recognition-particle GTPase (E.C. 3.6.5.4), dynamin GTPases (E.C. 3.6.5.5) and tubulin GTPases (E.C.
3.6.5.6).

Gene Wiki entry for DNM1


Genomic Views
for DNM1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DNM1 gene promoter:
         AP-2alpha isoform 3   AP-1   AP-2alpha isoform 2   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DNM1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DNM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34

DNM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNM1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P130965:  view genomic region     (about GC identifiers)

Start:
 130,965,658 bp from pter      End:
 131,017,527 bp from pter
Size:
 51,870 bases      Orientation:
 plus strand

Proteins
for DNM1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DYN1_HUMAN, Q05193 (See protein sequence)
Recommended Name: Dynamin-1  
Size: 864 amino acids; 97408 Da
Subunit: Interacts with CAV1 and SH3GLB1. Binds SH3GL1, SH3GL2 and SH3GL3 (By similarity). Interacts with PHOCN (By
similarity). Interacts with SNX9. Interacts with MYO1E (via SH3 domain)
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated
6/7 PDB 3D structures from and Proteopedia for DNM1 (see all 7):
1DYN (3D)        2DYN (3D)        2X2E (3D)        2X2F (3D)        3SNH (3D)        3ZYC (3D)    
Secondary accessions: A6NLM6 Q5SYX0 Q5SYX2 Q6P3T6 Q86VD2
Alternative splicing: 5 isoforms:  Q05193-1   Q05193-2   Q05193-3   Q05193-4   Q05193-5   

Explore the universe of human proteins at neXtProt for DNM1: NX_Q05193

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q05193

    • 4/41 DME Specific Peptides for DNM1 (Q05193) (see all 41)
     AEFLHCK  GVVNRSQ  GIMKGGS  TKLDLMD 

    DNM1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001005336.1  NP_004399.2  

    ENSEMBL proteins: 
     ENSP00000419225   ENSP00000345680   ENSP00000362014   ENSP00000377219   ENSP00000420045  
     ENSP00000420808  
    Reactome Protein details: Q05193
    Human Recombinant Protein Products: 
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DNM1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005874microtubule IEA--
    GO:0030117membrane coat IEA--


    DNM1 for ontologies           About GeneDecksing



    DNM1 Antibody Products: 
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    Cell Signaling Technology (CST) Antibodies for DNM1  (DYN1)
    OriGene Antibodies (see all 3): DNM1
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    Novus Biologicals DNM1 Antibodies
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    ThermoFisher Antibodies for DNM1

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    Uscn ELISAs and CLIAs for DNM1

    Protein Domains /
    Families
    for DNM1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DNM1 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR003130 GED
     IPR001401 Dynamin_GTPase
     IPR020850 GTPase_effector_domain_GED
     IPR001849 Pleckstrin_homology
     IPR022812 Dynamin

    Graphical View of Domain Structure for InterPro Entry Q05193

    ProtoNet protein and cluster: Q05193

    2 Blocks protein families:
    IPB001401 Dynamin
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: DYN1_HUMAN, Q05193
    Similarity: Belongs to the dynamin family
    Similarity: Contains 1 GED domain
    Similarity: Contains 1 PH domain


    Function
    for DNM1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DYN1_HUMAN, Q05193
    Function: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and
    hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis
    Catalytic activity: GTP + H(2)O = GDP + phosphate

         Genatlas biochemistry entry for DNM1:
    dynamin 1,100kDa,GTP binding protein,expressed in the brain,involved in early stage of clathrin-mediated endocytosis
    and formation of synaptic vesicles

    Enzyme Number (IUBMB): EC 3.6.5.51 2

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DNM1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate DNM1:
    hsa-miR-140-3p hsa-miR-224 hsa-miR-3065-3p hsa-miR-589* hsa-miR-3145-3p hsa-miR-3179 hsa-miR-4260
    SwitchGear 3'UTR luciferase reporter plasmid: DNM1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNM1 (see all 7)
    OriGene shRNA RFP: DNM1
    OriGene siRNA: DNM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNM1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DNM1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNM1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNM1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): DNM1 (NM_004408)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNM1 

    Cell Line
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    Search LifeMap BioReagents cell lines for DNM1

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNM1

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding IPI--
    GO:0005525GTP binding IEA--
    GO:0005543phospholipid binding IEA--
    GO:0008022protein C-terminus binding IEA--


    DNM1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Dnm1tm1Pdc for DNM1
         7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Dnm1):
     behavior/neurological  cellular  hearing/vestibular/ear  homeostasis/metabolism  mortality/aging 
     nervous system  normal 

    DNM1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DNM1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/27 super-pathways (see all 27) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axon guidance
    		Axon guidance1.00
    		L1CAM interactions0.39
    		Developmental Biology0.69
    		Recycling pathway of L10.15
    2Formation of annular gap junctions
    		Formation of annular gap junctions1.00
    		Lysosomal degradation of gap junction plaques0.92
    		Gap junction degradation0.92
    3Transport of MHC II:Ii complex along Golgi to TGN
    		Internalization of MHC II:Ii clathrin coated vesicle0.52
    		Retrograde neurotrophin signalling0.00
    		Endocytic Trafficking of EGFR0.00
    4Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    5Gap junction assembly
    		Gap junction trafficking0.74
    		Gap junction trafficking and regulation0.70

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DNM1
        Endocytic Trafficking of EGFR
    Remodeling of Adherens Junctions
    GnRH Signaling

    1 Cell Signaling Technology (CST) Pathway for DNM1
        Cytoskeletal Signaling

    5/11 BioSystems Pathways for DNM1 (see all 11) 
        EGFR1 Signaling Pathway
    Synaptic Vesicle Pathway
    IL-3 Signaling Pathway
    Thromboxane A2 receptor signaling
    Neurotrophic factor-mediated Trk receptor signaling

    5/18        Reactome Pathways for DNM1 (see all 18)
        L1CAM interactions
    Developmental Biology
    Internalization of MHC II:Ii clathrin coated vesicle
    Membrane Trafficking
    Formation of annular gap junctions


    4         Kegg Pathways  (Kegg details for DNM1):
        Endocytosis
    Fc gamma R-mediated phagocytosis
    Endocrine and other factor-regulated calcium reabsorption
    Bacterial invasion of epithelial cells


    DNM1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DNM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/128 Interacting proteins for DNM1 (Q051931, 2, 3 ENSP000003620144) via UniProtKB, MINT, STRING, and/or I2D (see all 128)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITSN1Q158112, 3, ENSP000003707194MINT-65948 MINT-65947 MINT-7302450 I2D: score=5 STRING: ENSP00000370719
    SNX9Q9Y5X12, 3, ENSP000003760244MINT-61333 MINT-62868 MINT-61330 I2D: score=2 STRING: ENSP00000376024
    ABL1P005192, 3, ENSP000003614234MINT-8110299 I2D: score=3 STRING: ENSP00000361423
    TIMM50Q3ZCQ82, 3, ENSP000003181154MINT-64669 I2D: score=3 STRING: ENSP00000318115
    DNM2P505702, 3, ENSP000003527214MINT-8254393 I2D: score=2 STRING: ENSP00000352721
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS10944110
    GO:0006897endocytosis IMP19706678
    GO:0006898receptor-mediated endocytosis IMP10521508
    GO:0007032endosome organization IMP19706678
    GO:0031623receptor internalization IEA--


    DNM1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DNM1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DNM1 for compounds           About GeneDecksing

    EMD Millipore small molecules for DNM1:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for DNM1

    Compounds for DNM1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Dynole 34-2Dynamin I inhibitor[1128165-88-7]
    Dynamin inhibitory peptide, myristoylated Cell-permeable dynamin inhibitor[251634-22-7]
    Dynamin inhibitory peptideDynamin inhibitor[251634-21-6]
    DynasoreNon-competitive dynamin inhibitor[304448-55-3]
    MitMABDynamin inhibitor[1119-97-7]

    4 HMDB Compounds for DNM1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    5 Novoseek chemical compound relationships for DNM1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphoinositide 46.8 2 11160859 (1), 9765310 (1)
    gtp 35.8 4 10559861 (1), 10074457 (1), 15954862 (1)
    phosphatidylinositol 15.8 1 18266936 (1)
    lipid 0 1 19776347 (1)
    calcium 0 3 16864575 (2), 10473536 (1)

    Search CenterWatch for drugs/clinical trials and news about DNM1 / DYN1 

    Transcripts
    for DNM1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DNM1 gene (2 alternative transcripts): 
    NM_001005336.1  NM_004408.2  

    Unigene Cluster for DNM1:

    Dynamin 1
    Hs.522413  [show with all ESTs]
    Unigene Representative Sequence: AK127038
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475805(uc022bnx.1) ENST00000341179(uc022bny.1 uc022bnz.1)
    ENST00000372923(uc022boa.1 uc022bob.1) ENST00000393594(uc004buc.1)
    ENST00000486160 ENST00000441149(uc004bub.1) ENST00000482638 ENST00000463998
    ENST00000479174 ENST00000493925

    miRNA
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    hsa-miR-140-3p hsa-miR-224 hsa-miR-3065-3p hsa-miR-589* hsa-miR-3145-3p hsa-miR-3179 hsa-miR-4260
    SwitchGear 3'UTR luciferase reporter plasmid: DNM1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNM1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNM1

    Additional cDNA sequence: 

    AF035321.1 AK127038.1 AK225179.1 AK295101.1 AK296326.1 AK308793.1 AK316235.1 BC050279.1 
    BC063850.1 L07807.1 L07808.1 L07809.1 L07810.1 

    14 DOTS entries:

    DT.100783547  DT.100025770  DT.40234572  DT.115646  DT.91747199  DT.75118572  DT.92377159  DT.121189880 
    DT.91748737  DT.95346782  DT.100000367  DT.101975761  DT.92005726  DT.121189853 

    24/138 AceView cDNA sequences (see all 138):

    BQ581673 T28122 BQ961890 BQ888183 BP360632 BQ882122 BM826534 BQ888167 
    BX463619 L07808 BU149199 AA323959 BC063850 BE048201 AU153788 BU073243 
    T12613 CR592374 BE699859 CD618678 AL039894 BM150325 AL120031 BG752643 

    GeneLoc Exon Structure


    Expression
    for DNM1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DNM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGGTGCTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DNM1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneMandibular CondyleBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)

    See DNM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DNM1

    SOURCE GeneReport for Unigene cluster: Hs.522413
        SABiosciences Expression via Pathway-Focused PCR Arrays including DNM1: 
              Adherens Junctions in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNM1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNM1

    Orthologs
    for DNM1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNM1 gene from 7/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DNM11 dynamin 1 83.99(n)
    96.3(a)    		   417217  XM_001233249.2  XP_001233250.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DNM16
    		 --
    		 89(a)
    		 1 ↔ 1
    		 GL343763.1(60422-169524)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BX853705.12   -- 82.05(n)    BX853705.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii dnm1b1 dynamin 1b 77.8(n)
    89.14(a)    		   100333543  XM_002662179.2  XP_002662225.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta shi1 , 3 cellularization actin binding3
    shibire1    		 68(a)3
    64.67(n)1
    70.71(a)1    		   1 13F183
    459281  NM_001169296.11  NP_001162767.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea dyn-11 , 3 dynamin3
    Protein DYN-11    		 67(a)3
    61.77(n)1
    65.25(a)1    		   X(15604145-15608173)3
    1816441  NM_001029161.11  NP_001024332.11 
    rice
    (Oryza sativa)    		 Liliopsida Os.190792 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 71.26(n)    AK073965.1 


    ENSEMBL Gene Tree for DNM1 (if available)
    TreeFam Gene Tree for DNM1 (if available) 

    Paralogs
    for DNM1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DNM1 gene
    MX22  DNM22  DNM32  MX12  
    5 SIMAP similar genes for DNM1 using alignment to 2 protein entries:     DYN1_HUMAN (see all proteins):
    DNM3    DNM2    DNM1P34    DNM1L    MX2

    DNM1 for paralogs           About GeneDecksing


    5/25 Pseudogenes.org Pseudogenes for DNM1 (see all 25)
    PGOHUM00000261091 PGOHUM00000261166 PGOHUM00000261167 PGOHUM00000261168 PGOHUM00000261173


    Genomic Variants
    for DNM1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/865 NCBI SNPs in DNM1 are shown (see all 865)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs109879261,2
    		--100577132(+) CTCCAA/GCCTGG 2 -- us2k10--------
    rs109879271,2
    		C,F,H,--100577535(+) acgcaG/Acttgt 2 -- us2k120Minor allele frequency- A:0.03NS EA NA WA CSA 1849
    rs455433331,2
    		C,F,--100578160(-) CCAACC/TCATCA 2 -- us2k15Minor allele frequency- T:0.01NS 188
    rs454708921,2
    		C,F--100578417(-) TGGAGG/CAAATA 2 -- us2k16Minor allele frequency- C:0.01NS CSA 188
    rs743172961,2
    		--100578514(+) ATCTAT/AGAGGG 2 -- us2k11Minor allele frequency- A:0.01WA 118
    rs779326431,2
    		--100578688(+) TCAGAC/GTCAGG 2 -- us2k10--------
    rs1126650811,2
    		--100579506(+) ACCACC/GAGAGC 2 -- int11Minor allele frequency- G:0.00CSA 1
    rs78514731,2
    		C,--100580264(+) GCGGGA/GCAGGC 2 -- int10--------
    rs781953521,2
    		--100580672(+) CCCCTC/TAAATG 2 -- int10--------
    rs455964351,2
    		C,F,--100580775(-) GGGCAC/TGGCCG 2 -- int16Minor allele frequency- T:0.06NS WA 302

    HapMap Linkage Disequilibrium report for DNM1 (130965658 - 131017527 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DNM1: --
    Human Gene Mutation Database (HGMD): DNM1

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    Disorders / Diseases
    for DNM1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DNM1 for disorders           About GeneDecksing

    OMIM gene information: 602377    OMIM disorders: --

    20/23 diseases for DNM1 (see all 23):    About MalaCards
    neuronal intranuclear inclusion disease    wiskott-aldrich syndrome    pleural empyema    nicotine dependence
    optic atrophy    pericarditis    rett syndrome    herpes simplex
    cystic fibrosis    mediastinitis    neurodegeneration    down syndrome
    adhd    gout    fibrosis    alzheimer's disease
    pharyngitis    influenza    cholesterol    schizophrenia

    2 Novoseek disease relationships for DNM1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurodegeneration 28.2 1 16864575 (1)
    senile plaques 19.7 1 16864575 (1)

    Human Genome Epidemiology (HuGE) Navigator: DNM1 (1 document)

    Export disorders for DNM1 gene to outside databases

    Publications
    for DNM1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DNM1 gene, integrated from 9 sources (see all 182):
    (articles sorted by number of sources associating them with DNM1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the dynamin-1 gene (DNM1) to human chromosome 9q34 by fluorescence in situ hybridization and somatic cell hybrid analysis. (PubMed id 9143509)1, 3, 9 Newman-Smith E.D....van der Bliek A.M. (1997)
    2. SNX9 regulates dynamin assembly and is required for e fficient clathrin-mediated endocytosis. (PubMed id 15703209)1, 2, 9 Soulet F....Schmid S.L. (2005)
    3. Crystal structure of the pleckstrin homology domain from dynamin. (PubMed id 7634088)1, 2 Timm D.... Blundell T. (1994)
    4. Crystal structure at 2.2-A resolution of the pleckstrin homology domain from human dynamin. (PubMed id 7954789)1, 2 Ferguson K.M.... Sigler P.B. (1994)
    5. Three-dimensional solution structure of the pleckstrin homology domain from dynamin. (PubMed id 7850421)1, 2 Downing A.K....Waterfield M.D. (1994)
    6. Mutations in human dynamin block an intermediate stage in coated vesicle formation. (PubMed id 8101525)1, 2 van der Bliek A.M....Schmid S.L. (1993)
    7. Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTP-binding proteins. (PubMed id 2144893)1, 3 Obar R.A....Vallee R.B. (1990)
    8. Mnb/Dyrk1A phosphorylation regulates the interaction of dynamin 1 with SH3 domain-containing proteins. (PubMed id 15287745)1, 9 Huang Y....Hwang Y.W. (2004)
    9. Detection of Genetic Association and a Functional Polymorphism of Dynamin 1 Gene with Nicotine Dependence in European and African Americans. (PubMed id 18987626)1, 9 Xu Q....Li M.D. (2008)
    10. Kinetics of Src homology 3 domain association with the proline-rich domain of dynamins: specificity, occlusion, and the effects of phosphorylation. (PubMed id 15834155)1, 9 Solomaha E....Palfrey H.C. (2005)

    External Searches for DNM1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DNM1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1759 HGNC: 2972 AceView: DNM1 Ensembl:ENSG00000106976 euGenes: HUgn1759
    ECgene: DNM1 Kegg: 1759 H-InvDB: DNM1

    Other Databases showing DNM1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DNM1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DNM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DNM1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for DNM1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DNM1 gene:
    Search GeneIP for patents involving DNM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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