DNLZ Gene
protein-coding GIFtS: 34
GCID: GC09M139253
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DNL-type zinc finger(Previous name: chromosome 9 open reading frame 151 )
(Previous symbol: C9orf151)
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Aliases
for DNLZ gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DNL-Type Zinc Finger1 2 | | BA413M3.21 | | C9orf1511 2 3 | | Chromosome 9 Open Reading Frame 1511 | | HEP1 2 | | DNL-Type Zinc Finger Protein2 | | RP11-413M3.21 2 | | HSP70 Escort Protein2 | | TIMM151 2 | | Translocase Of Inner Mitochondrial Membrane 15 Homolog2 | | ZIM171 2 | | |
Export aliases for DNLZ gene to outside databasesPrevious GC identifers: GC09M138380 GC09M108715 |
Summaries
for DNLZ gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for DNLZ gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_024000.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DNLZ gene promoter:
NF-1 SREBP-1c Pax-6 NF-kappaB SREBP-1b c-Ets-1 PPAR-gamma1 SREBP-1a PPAR-gamma2 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DNLZ
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNLZ |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34.3DNLZ Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M139253: view genomic region
(about GC identifiers)
Start:
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139,253,932 bp from pter |
End:
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139,258,241 bp from pter |
Size:
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4,310 bases |
Orientation:
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minus strand |
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Proteins
for DNLZ gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DNLZ_HUMAN, Q5SXM8 (See
protein sequence)Recommended Name: DNL-type zinc finger protein Size: 178 amino acids; 19204 Da
Secondary accessions: B2RUX5 B9EJE1Explore the universe of human proteins at neXtProt for DNLZ: NX_Q5SXM8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5SXM8
DNLZ Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001074318.1
ENSEMBL proteins: ENSP00000360804 ENSP00000360803
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005739 | mitochondrion |
IEA | -- |
DNLZ for ontologies About GeneDecksing
DNLZ Antibody Products:
Assay Products for DNLZ: |
Protein
Domains /
Families
for DNLZ gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DNLZ for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5SXM8ProtoNet protein and cluster: Q5SXM8 UniProtKB/Swiss-Prot: DNLZ_HUMAN, Q5SXM8Similarity: Contains 1 DNL-type zinc finger |
Function
for DNLZ gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNLZ (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNLZ
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DNLZ (NM_001080849) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DNLZ | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNLZ |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
DNLZ for ontologies About GeneDecksing
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Pathways & Interactions
for DNLZ gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNLZ
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for DNLZ (ENSP000003608034) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for DNLZ gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DNLZ
Search CenterWatch for drugs/clinical trials and news about DNLZ
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Transcripts
for DNLZ gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for DNLZ gene: NM_001080849.2 Unigene Cluster for DNLZ: DNL-type zinc finger Hs.528581 [show with all ESTs]Unigene Representative Sequence: BM8056072 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000371739 ENST00000371738(uc004chf.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNLZ (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNLZ
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DNLZ (NM_001080849) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DNLZ | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNLZ |
Additional cDNA sequence: BC146915.1 BC146924.1 BC171835.1 3 DOTS entries: DT.104625 DT.99967841 DT.95224468
GeneLoc Exon Structure
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Expression
for DNLZ gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DNLZ expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See DNLZ Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DNLZ
SOURCE GeneReport for Unigene cluster: Hs.528581
SABiosciences Custom PCR Arrays for DNLZ
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNLZ
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DNLZ | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNLZ | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNLZ |
Orthologs
for DNLZ gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for DNLZ gene from 8/24 species (see all 24) About this table
ENSEMBL Gene Tree for DNLZ (if available)
TreeFam Gene Tree for DNLZ (if available) |
Paralogs
for DNLZ gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for DNLZ gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for DNLZ (139253932 - 139258241 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for DNLZ
6 CNVs: 30353 3785 30350 30354 30355 0133 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNLZ |
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Disorders
/ Diseases
for DNLZ gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for DNLZ gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DNLZ gene integrated from 9 sources:
(articles sorted by number of sources associating them with DNLZ) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNLZ/HEP zinc-binding subdomain is critical for r egulation of the mitochondrial chaperone HSPA9. (PubMed id 22162012)1, 3 Vu M.T....Silberg J.J. (2012)
- A conserved histidine in human DNLZ/HEP is required f or stimulation of HSPA9 ATPase activity. (PubMed id 21530495)1, 3 Zhai P....Silberg J.J. (2011)
- The human escort protein Hep binds to the ATPase domain of mitochondrial hsp70 and regulates ATP hydrolysis. (PubMed id 18632665)1 Zhai P....Silberg J.J. (2008)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for DNLZ gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing DNLZ gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing DNLZ gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DNLZ gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DNLZ | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for DNLZ gene:
Search GeneIP for patents involving DNLZ
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DNLZ gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DNLZ | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNLZ | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNLZ | | | OriGene Protein Over-expression Lysate for DNLZ | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DNLZ | | OriGene 3'-UTR Clone for DNLZ | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNLZ | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNLZ | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DNLZ | | OriGene Custom Protein Services for DNLZ | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DNLZ | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNLZ | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNLZ | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNLZ | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNLZ | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNLZ |
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| | | | Search Tocris compounds for DNLZ |
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 | | | DNLZ Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for DNLZ |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNLZ |
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