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Aliases for DNLZ Gene

Aliases for DNLZ Gene

  • DNL-Type Zinc Finger 2 3 5
  • Hsp70-Escort Protein 1 3 4
  • MtHsp70-Escort Protein 3 4
  • HSP70 Escort Protein 2 3
  • C9orf151 3 4
  • HEP1 3 4
  • Translocase Of Inner Mitochondrial Membrane 15 Homolog (Yeast) 2
  • Translocase Of Inner Mitochondrial Membrane 15 Homolog 3
  • Chromosome 9 Open Reading Frame 151 2
  • DNL-Type Zinc Finger Protein 3
  • RP11-413M3.2 3
  • BA413M3.2 3
  • TIMM15 3
  • ZIM17 3
  • HEP 3

External Ids for DNLZ Gene

Previous HGNC Symbols for DNLZ Gene

  • C9orf151

Previous GeneCards Identifiers for DNLZ Gene

  • GC09M138380
  • GC09M139253
  • GC09M108715

Summaries for DNLZ Gene

GeneCards Summary for DNLZ Gene

DNLZ (DNL-Type Zinc Finger) is a Protein Coding gene. GO annotations related to this gene include chaperone binding.

UniProtKB/Swiss-Prot for DNLZ Gene

  • May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNLZ Gene

Genomics for DNLZ Gene

Regulatory Elements for DNLZ Gene

Enhancers for DNLZ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DNLZ on UCSC Golden Path with GeneCards custom track

Promoters for DNLZ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DNLZ on UCSC Golden Path with GeneCards custom track

Genomic Location for DNLZ Gene

Chromosome:
9
Start:
136,359,480 bp from pter
End:
136,363,811 bp from pter
Size:
4,332 bases
Orientation:
Minus strand

Genomic View for DNLZ Gene

Genes around DNLZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNLZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNLZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNLZ Gene

Proteins for DNLZ Gene

  • Protein details for DNLZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SXM8-DNLZ_HUMAN
    Recommended name:
    DNL-type zinc finger protein
    Protein Accession:
    Q5SXM8
    Secondary Accessions:
    • B2RUX5
    • B9EJE1

    Protein attributes for DNLZ Gene

    Size:
    178 amino acids
    Molecular mass:
    19204 Da
    Quaternary structure:
    • Oligomerizes in a concentration-dependent fashion. Interacts with HSPA9.

neXtProt entry for DNLZ Gene

Post-translational modifications for DNLZ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNLZ Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNLZ Gene

Domains & Families for DNLZ Gene

Gene Families for DNLZ Gene

Protein Domains for DNLZ Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DNLZ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5SXM8

UniProtKB/Swiss-Prot:

DNLZ_HUMAN :
  • Contains 1 DNL-type zinc finger.
Similarity:
  • Contains 1 DNL-type zinc finger.
genes like me logo Genes that share domains with DNLZ: view

Function for DNLZ Gene

Molecular function for DNLZ Gene

UniProtKB/Swiss-Prot Function:
May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation.

Gene Ontology (GO) - Molecular Function for DNLZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0051087 chaperone binding IBA --
genes like me logo Genes that share ontologies with DNLZ: view

Phenotypes for DNLZ Gene

genes like me logo Genes that share phenotypes with DNLZ: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNLZ Gene

Localization for DNLZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNLZ Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNLZ Gene COMPARTMENTS Subcellular localization image for DNLZ gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for DNLZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA --
genes like me logo Genes that share ontologies with DNLZ: view

Pathways & Interactions for DNLZ Gene

SuperPathways for DNLZ Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNLZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA --
GO:0030150 protein import into mitochondrial matrix IBA --
GO:0050821 protein stabilization IBA --
genes like me logo Genes that share ontologies with DNLZ: view

No data available for Pathways by source and SIGNOR curated interactions for DNLZ Gene

Drugs & Compounds for DNLZ Gene

No Compound Related Data Available

Transcripts for DNLZ Gene

mRNA/cDNA for DNLZ Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DNLZ Gene

DNL-type zinc finger:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNLZ Gene

No ASD Table

Relevant External Links for DNLZ Gene

GeneLoc Exon Structure for
DNLZ
ECgene alternative splicing isoforms for
DNLZ

Expression for DNLZ Gene

mRNA expression in normal human tissues for DNLZ Gene

Protein differential expression in normal tissues from HIPED for DNLZ Gene

This gene is overexpressed in Heart (14.1), Peripheral blood mononuclear cells (12.5), Bone marrow stromal cell (10.8), and CD8 Tcells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNLZ Gene



Protein tissue co-expression partners for DNLZ Gene

NURSA nuclear receptor signaling pathways regulating expression of DNLZ Gene:

DNLZ

SOURCE GeneReport for Unigene cluster for DNLZ Gene:

Hs.528581
genes like me logo Genes that share expression patterns with DNLZ: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DNLZ Gene

Orthologs for DNLZ Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNLZ Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNLZ 34
  • 81.85 (n)
  • 75.74 (a)
DNLZ 35
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNLZ 34
  • 81.85 (n)
  • 78.11 (a)
DNLZ 35
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnlz 34
  • 80.28 (n)
  • 75.74 (a)
Dnlz 16
Dnlz 35
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DNLZ 34
  • 98.88 (n)
  • 98.31 (a)
DNLZ 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnlz 34
  • 77.07 (n)
  • 72.25 (a)
oppossum
(Monodelphis domestica)
Mammalia DNLZ 35
  • 36 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNLZ 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNLZ 34
  • 69.94 (n)
  • 65.18 (a)
DNLZ 35
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNLZ 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnlz 34
  • 57.68 (n)
  • 53.29 (a)
zebrafish
(Danio rerio)
Actinopterygii dnlz 35
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12379 35
  • 36 (a)
OneToMany
CG8206 35
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F53A3.7 35
  • 46 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZIM17 35
  • 25 (a)
OneToOne
ZIM17 37
Species where no ortholog for DNLZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNLZ Gene

ENSEMBL:
Gene Tree for DNLZ (if available)
TreeFam:
Gene Tree for DNLZ (if available)

Paralogs for DNLZ Gene

No data available for Paralogs for DNLZ Gene

Variants for DNLZ Gene

Sequence variations from dbSNP and Humsavar for DNLZ Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs3812553 - 136,362,043(+) TGGGG(G/T)GACCC nc-transcript-variant, reference, missense
rs3812552 - 136,362,016(+) GTCAG(C/G/T)TCGGC nc-transcript-variant, reference, missense
rs10121646 -- 136,362,835(+) TTATA(A/G)GAAAT intron-variant
rs117480558 -- 136,362,371(+) GTATG(C/T)GCCGC intron-variant
rs10747047 -- 136,361,689(+) CGCAG(C/T)GACAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for DNLZ Gene

Variant ID Type Subtype PubMed ID
esv2759720 CNV loss 17122850
nsv1046074 CNV gain 25217958
nsv469918 CNV loss 18288195
nsv509333 CNV insertion 20534489
nsv615962 CNV loss 21841781
nsv6764 CNV deletion 18451855
nsv825173 CNV gain 20364138
nsv951202 CNV deletion 24416366

Variation tolerance for DNLZ Gene

Residual Variation Intolerance Score: 94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.03; 68.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNLZ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNLZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNLZ Gene

Disorders for DNLZ Gene

Relevant External Links for DNLZ

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNLZ

No disorders were found for DNLZ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNLZ Gene

Publications for DNLZ Gene

  1. Structural and stability studies of the human mtHsp70-escort protein 1: An essential mortalin co-chaperone. (PMID: 23462535) Dores-Silva P.R. … Borges J.C. (Int. J. Biol. Macromol. 2013) 3 4 65
  2. The DNLZ/HEP zinc-binding subdomain is critical for regulation of the mitochondrial chaperone HSPA9. (PMID: 22162012) Vu M.T. … Silberg J.J. (Protein Sci. 2012) 2 3 65
  3. A conserved histidine in human DNLZ/HEP is required for stimulation of HSPA9 ATPase activity. (PMID: 21530495) Zhai P. … Silberg J.J. (Biochem. Biophys. Res. Commun. 2011) 2 3 65
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 65

Products for DNLZ Gene

Sources for DNLZ Gene

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