Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DNLZ Gene

Aliases for DNLZ Gene

  • DNL-Type Zinc Finger 2 3 5
  • Hsp70-Escort Protein 1 3 4
  • MtHsp70-Escort Protein 3 4
  • HSP70 Escort Protein 2 3
  • C9orf151 3 4
  • HEP1 3 4
  • Translocase Of Inner Mitochondrial Membrane 15 Homolog (Yeast) 2
  • Translocase Of Inner Mitochondrial Membrane 15 Homolog 3
  • Chromosome 9 Open Reading Frame 151 2
  • RP11-413M3.2 3
  • BA413M3.2 3
  • TIMM15 3
  • ZIM17 3
  • HEP 3

External Ids for DNLZ Gene

Previous HGNC Symbols for DNLZ Gene

  • C9orf151

Previous GeneCards Identifiers for DNLZ Gene

  • GC09M138380
  • GC09M139253
  • GC09M108715

Summaries for DNLZ Gene

GeneCards Summary for DNLZ Gene

DNLZ (DNL-Type Zinc Finger) is a Protein Coding gene. GO annotations related to this gene include chaperone binding.

UniProtKB/Swiss-Prot for DNLZ Gene

  • May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNLZ Gene

Genomics for DNLZ Gene

Regulatory Elements for DNLZ Gene

Enhancers for DNLZ Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DNLZ on UCSC Golden Path with GeneCards custom track

Promoters for DNLZ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DNLZ on UCSC Golden Path with GeneCards custom track

Genomic Location for DNLZ Gene

136,359,480 bp from pter
136,363,811 bp from pter
4,332 bases
Minus strand

Genomic View for DNLZ Gene

Genes around DNLZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNLZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNLZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNLZ Gene

Proteins for DNLZ Gene

  • Protein details for DNLZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DNL-type zinc finger protein
    Protein Accession:
    Secondary Accessions:
    • B2RUX5
    • B9EJE1

    Protein attributes for DNLZ Gene

    178 amino acids
    Molecular mass:
    19204 Da
    Quaternary structure:
    • Oligomerizes in a concentration-dependent fashion. Interacts with HSPA9.

neXtProt entry for DNLZ Gene

Proteomics data for DNLZ Gene at MOPED

Post-translational modifications for DNLZ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNLZ Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNLZ Gene

Domains & Families for DNLZ Gene

Gene Families for DNLZ Gene

Protein Domains for DNLZ Gene


Suggested Antigen Peptide Sequences for DNLZ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DNL-type zinc finger.
  • Contains 1 DNL-type zinc finger.
genes like me logo Genes that share domains with DNLZ: view

Function for DNLZ Gene

Molecular function for DNLZ Gene

UniProtKB/Swiss-Prot Function:
May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation.

Phenotypes for DNLZ Gene

genes like me logo Genes that share phenotypes with DNLZ: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNLZ Gene

Localization for DNLZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNLZ Gene


Subcellular locations from

Jensen Localization Image for DNLZ Gene COMPARTMENTS Subcellular localization image for DNLZ gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for DNLZ Gene

Pathways & Interactions for DNLZ Gene

SuperPathways for DNLZ Gene

No Data Available

Interacting Proteins for DNLZ Gene

Gene Ontology (GO) - Biological Process for DNLZ Gene


No data available for Pathways by source and SIGNOR curated interactions for DNLZ Gene

Drugs & Compounds for DNLZ Gene

No Compound Related Data Available

Transcripts for DNLZ Gene

mRNA/cDNA for DNLZ Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DNLZ Gene

DNL-type zinc finger:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNLZ Gene

No ASD Table

Relevant External Links for DNLZ Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNLZ Gene

mRNA expression in normal human tissues for DNLZ Gene

Protein differential expression in normal tissues from HIPED for DNLZ Gene

This gene is overexpressed in Heart (14.1), Peripheral blood mononuclear cells (12.5), Bone marrow stromal cell (10.8), and CD8 Tcells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNLZ Gene

SOURCE GeneReport for Unigene cluster for DNLZ Gene Hs.528581

genes like me logo Genes that share expression patterns with DNLZ: view

Protein tissue co-expression partners for DNLZ Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DNLZ Gene

Orthologs for DNLZ Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNLZ Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DNLZ 35
  • 81.85 (n)
  • 75.74 (a)
  • 75 (a)
(Canis familiaris)
Mammalia DNLZ 35
  • 81.85 (n)
  • 78.11 (a)
  • 75 (a)
(Mus musculus)
Mammalia Dnlz 35
  • 80.28 (n)
  • 75.74 (a)
Dnlz 16
Dnlz 36
  • 70 (a)
(Pan troglodytes)
Mammalia DNLZ 35
  • 98.88 (n)
  • 98.31 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Dnlz 35
  • 77.07 (n)
  • 72.25 (a)
(Monodelphis domestica)
Mammalia DNLZ 36
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia DNLZ 36
  • 59 (a)
(Gallus gallus)
Aves DNLZ 35
  • 69.94 (n)
  • 65.18 (a)
  • 43 (a)
(Anolis carolinensis)
Reptilia DNLZ 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnlz 35
  • 57.68 (n)
  • 53.29 (a)
(Danio rerio)
Actinopterygii dnlz 36
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12379 36
  • 36 (a)
CG8206 36
  • 21 (a)
(Caenorhabditis elegans)
Secernentea F53A3.7 36
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZIM17 36
  • 25 (a)
ZIM17 38
Species with no ortholog for DNLZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNLZ Gene

Gene Tree for DNLZ (if available)
Gene Tree for DNLZ (if available)

Paralogs for DNLZ Gene

No data available for Paralogs for DNLZ Gene

Variants for DNLZ Gene

Sequence variations from dbSNP and Humsavar for DNLZ Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs3812553 - 136,362,043(+) TGGGG(G/T)GACCC nc-transcript-variant, reference, missense
rs3812552 - 136,362,016(+) GTCAG(C/G/T)TCGGC nc-transcript-variant, reference, missense
rs113727969 -- 136,363,297(+) GCCCC(A/G/T)CCCCA intron-variant
rs114785819 -- 136,362,999(+) CCCAT(C/T)CAGGT nc-transcript-variant, reference, missense
rs117480558 -- 136,362,371(+) GTATG(C/T)GCCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNLZ Gene

Variant ID Type Subtype PubMed ID
nsv825173 CNV Gain 20364138
nsv894294 CNV Loss 21882294
dgv8383n71 CNV Loss 21882294
dgv8384n71 CNV Loss 21882294
dgv8385n71 CNV Loss 21882294
dgv8386n71 CNV Loss 21882294
dgv8387n71 CNV Loss 21882294
dgv8389n71 CNV Loss 21882294
dgv8390n71 CNV Loss 21882294
dgv8392n71 CNV Loss 21882294
dgv8393n71 CNV Loss 21882294
nsv894357 CNV Loss 21882294
nsv894359 CNV Loss 21882294
nsv6764 CNV Loss 18451855
nsv509333 CNV Insertion 20534489
nsv482928 CNV Loss 15286789
dgv2426e1 CNV Complex 17122850
nsv894361 CNV Loss 21882294
nsv469918 CNV Loss 18288195
dgv8394n71 CNV Loss 21882294

Variation tolerance for DNLZ Gene

Residual Variation Intolerance Score: 94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.03; 68.57% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DNLZ Gene

Disorders for DNLZ Gene

Relevant External Links for DNLZ

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DNLZ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNLZ Gene

Publications for DNLZ Gene

  1. Structural and stability studies of the human mtHsp70-escort protein 1: An essential mortalin co-chaperone. (PMID: 23462535) Dores-Silva P.R. … Borges J.C. (Int. J. Biol. Macromol. 2013) 3 4 67
  2. The DNLZ/HEP zinc-binding subdomain is critical for regulation of the mitochondrial chaperone HSPA9. (PMID: 22162012) Vu M.T. … Silberg J.J. (Protein Sci. 2012) 2 3
  3. A conserved histidine in human DNLZ/HEP is required for stimulation of HSPA9 ATPase activity. (PMID: 21530495) Zhai P. … Silberg J.J. (Biochem. Biophys. Res. Commun. 2011) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. The human escort protein Hep binds to the ATPase domain of mitochondrial hsp70 and regulates ATP hydrolysis. (PMID: 18632665) Zhai P. … Silberg J.J. (J. Biol. Chem. 2008) 3

Products for DNLZ Gene

Sources for DNLZ Gene