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Aliases for DNLZ Gene

Aliases for DNLZ Gene

  • DNL-Type Zinc Finger 2 3
  • Hsp70-Escort Protein 1 3 4
  • MtHsp70-Escort Protein 3 4
  • HSP70 Escort Protein 2 3
  • C9orf151 3 4
  • HEP1 3 4
  • Translocase Of Inner Mitochondrial Membrane 15 Homolog (Yeast) 2
  • Translocase Of Inner Mitochondrial Membrane 15 Homolog 3
  • Chromosome 9 Open Reading Frame 151 2
  • DNL-Type Zinc Finger Protein 3
  • RP11-413M3.2 3
  • BA413M3.2 3
  • TIMM15 3
  • ZIM17 3
  • HEP 3

External Ids for DNLZ Gene

Previous Symbols for DNLZ Gene

  • C9orf151

Summaries for DNLZ Gene

GeneCards Summary for DNLZ Gene

DNLZ (DNL-Type Zinc Finger) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DNLZ Gene

  • May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNLZ Gene

Genomics for DNLZ Gene

Genomic Location for DNLZ Gene

Start:
136,359,480 bp from pter
End:
136,363,811 bp from pter
Size:
4,332 bases
Orientation:
Minus strand

Genomic View for DNLZ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNLZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNLZ Gene

Proteins for DNLZ Gene

  • Protein details for DNLZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SXM8-DNLZ_HUMAN
    Recommended name:
    DNL-type zinc finger protein
    Protein Accession:
    Q5SXM8
    Secondary Accessions:
    • B2RUX5
    • B9EJE1

    Protein attributes for DNLZ Gene

    Size:
    178 amino acids
    Molecular mass:
    19204 Da
    Quaternary structure:
    • Oligomerizes in a concentration-dependent fashion. Interacts with HSPA9.

neXtProt entry for DNLZ Gene

Proteomics data for DNLZ Gene at MOPED

Post-translational modifications for DNLZ Gene

No Post-translational modifications

Other Protein References for DNLZ Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNLZ Gene

Domains for DNLZ Gene

Gene Families for DNLZ Gene

HGNC:

Protein Domains for DNLZ Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

DNLZ_HUMAN
Similarity:
  • Contains 1 DNL-type zinc finger.:
    • Q5SXM8
genes like me logo Genes that share domains with DNLZ: view

Function for DNLZ Gene

Molecular function for DNLZ Gene

UniProtKB/Swiss-Prot Function: May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation.

Gene Ontology (GO) - Molecular Function for DNLZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0051087 chaperone binding IBA --
genes like me logo Genes that share ontologies with DNLZ: view

miRNA for DNLZ Gene

miRTarBase miRNAs that target DNLZ

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DNLZ Gene

Localization for DNLZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNLZ Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNLZ Gene COMPARTMENTS Subcellular localization image for DNLZ gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for DNLZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA --
genes like me logo Genes that share ontologies with DNLZ: view

Pathways for DNLZ Gene

SuperPathways for DNLZ Gene

No Data Available

Interacting Proteins for DNLZ Gene

Gene Ontology (GO) - Biological Process for DNLZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA --
GO:0030150 protein import into mitochondrial matrix IBA --
GO:0050821 protein stabilization IBA --
genes like me logo Genes that share ontologies with DNLZ: view

No data available for Pathways by source for DNLZ Gene

Transcripts for DNLZ Gene

mRNA/cDNA for DNLZ Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DNLZ Gene

DNL-type zinc finger:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNLZ Gene

No ASD Table

Relevant External Links for DNLZ Gene

GeneLoc Exon Structure for
DNLZ
ECgene alternative splicing isoforms for
DNLZ

Expression for DNLZ Gene

mRNA expression in normal human tissues for DNLZ Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNLZ Gene

SOURCE GeneReport for Unigene cluster for DNLZ Gene Hs.528581

genes like me logo Genes that share expressions with DNLZ: view

Orthologs for DNLZ Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNLZ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNLZ 36
  • 98.88 (n)
  • 98.31 (a)
DNLZ 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNLZ 36
  • 81.85 (n)
  • 75.74 (a)
DNLZ 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNLZ 36
  • 81.85 (n)
  • 78.11 (a)
DNLZ 37
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnlz 36
  • 80.28 (n)
  • 75.74 (a)
Dnlz 16
Dnlz 37
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNLZ 37
  • 36 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNLZ 37
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnlz 36
  • 77.07 (n)
  • 72.25 (a)
chicken
(Gallus gallus)
Aves DNLZ 36
  • 69.94 (n)
  • 65.18 (a)
DNLZ 37
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNLZ 37
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnlz 36
  • 57.68 (n)
  • 53.29 (a)
zebrafish
(Danio rerio)
Actinopterygii dnlz 37
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12379 37
  • 36 (a)
OneToMany
CG8206 37
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F53A3.7 37
  • 46 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZIM17 37
  • 25 (a)
OneToOne
ZIM17 39
Species with no ortholog for DNLZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNLZ Gene

ENSEMBL:
Gene Tree for DNLZ (if available)
TreeFam:
Gene Tree for DNLZ (if available)

Paralogs for DNLZ Gene

No data available for Paralogs for DNLZ Gene

Variants for DNLZ Gene

Sequence variations from dbSNP and Humsavar for DNLZ Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs3812552 - 136,362,016(+) GTCAG(C/G)TCGGC missense, reference, nc-transcript-variant
rs3812553 - 136,362,043(+) TGGGG(G/T)GACCC missense, reference, nc-transcript-variant
rs3812554 -- 136,362,089(+) GGGGG(C/T)CCCTG missense, reference, nc-transcript-variant
rs3829109 -- 136,362,314(+) CACAC(A/G)GGCAC intron-variant
rs4255257 -- 136,362,784(+) AAAAC(A/C/G)CACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNLZ Gene

Variant ID Type Subtype PubMed ID
nsv825173 CNV Gain 20364138
nsv894294 CNV Loss 21882294
dgv8383n71 CNV Loss 21882294
dgv8384n71 CNV Loss 21882294
dgv8385n71 CNV Loss 21882294
dgv8386n71 CNV Loss 21882294
dgv8387n71 CNV Loss 21882294
dgv8389n71 CNV Loss 21882294
dgv8390n71 CNV Loss 21882294
dgv8392n71 CNV Loss 21882294
dgv8393n71 CNV Loss 21882294
nsv894357 CNV Loss 21882294
nsv894359 CNV Loss 21882294
nsv6764 CNV Loss 18451855
nsv509333 CNV Insertion 20534489
nsv482928 CNV Loss 15286789
dgv2426e1 CNV Complex 17122850
nsv894361 CNV Loss 21882294
nsv469918 CNV Loss 18288195
dgv8394n71 CNV Loss 21882294

Relevant External Links for DNLZ Gene

HapMap Linkage Disequilibrium report
DNLZ

Disorders for DNLZ Gene

No disorders were found for DNLZ Gene.

No data available for UniProtKB/Swiss-Prot for DNLZ Gene

Publications for DNLZ Gene

  1. A conserved histidine in human DNLZ/HEP is required for stimulation of HSPA9 ATPase activity. (PMID: 21530495) Zhai P. … Silberg J.J. (Biochem. Biophys. Res. Commun. 2011) 2 3
  2. The DNLZ/HEP zinc-binding subdomain is critical for regulation of the mitochondrial chaperone HSPA9. (PMID: 22162012) Vu M.T. … Silberg J.J. (Protein Sci. 2012) 2 3
  3. Structural and stability studies of the human mtHsp70-escort protein 1: An essential mortalin co-chaperone. (PMID: 23462535) Dores-Silva P.R. … Borges J.C. (Int. J. Biol. Macromol. 2013) 3 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for DNLZ Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate DNLZ
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for DNLZ
    • Block miRNA regulation of DNLZ using miScript Target Protectors

    Sources for DNLZ Gene

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