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Aliases for DNHD1 Gene

Aliases for DNHD1 Gene

  • Dynein Heavy Chain Domain 1 2 3 5
  • Dynein Heavy Chain Domain 1-Like Protein 3 4
  • Coiled-Coil Domain Containing 35 2 3
  • C11orf47 3 4
  • CCDC35 3 4
  • DNHD1L 3 4
  • DHCD1 3 4
  • Chromosome 11 Open Reading Frame 47 2
  • Dynein Heavy Chain Domain 1-Like 2
  • DNHD1 Variant Protein 3
  • Protein CCDC35 4

External Ids for DNHD1 Gene

Previous HGNC Symbols for DNHD1 Gene

  • DHCD1
  • C11orf47
  • DNHD1L
  • CCDC35

Previous GeneCards Identifiers for DNHD1 Gene

  • GC11P006178

Summaries for DNHD1 Gene

GeneCards Summary for DNHD1 Gene

DNHD1 (Dynein Heavy Chain Domain 1) is a Protein Coding gene. GO annotations related to this gene include microtubule motor activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNHD1 Gene

Genomics for DNHD1 Gene

Regulatory Elements for DNHD1 Gene

Genomic Location for DNHD1 Gene

Chromosome:
11
Start:
6,497,260 bp from pter
End:
6,593,758 bp from pter
Size:
96,499 bases
Orientation:
Plus strand

Genomic View for DNHD1 Gene

Genes around DNHD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNHD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNHD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNHD1 Gene

Proteins for DNHD1 Gene

  • Protein details for DNHD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96M86-DNHD1_HUMAN
    Recommended name:
    Dynein heavy chain domain-containing protein 1
    Protein Accession:
    Q96M86
    Secondary Accessions:
    • Q2NKK8
    • Q6UWI9
    • Q8NAA2
    • Q8TEE6
    • Q9NSZ9

    Protein attributes for DNHD1 Gene

    Size:
    4753 amino acids
    Molecular mass:
    533644 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ89130.1; Type=Frameshift; Positions=637; Evidence={ECO:0000305}; Sequence=BAB85004.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAB70845.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=EAW68692.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for DNHD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNHD1 Gene

Proteomics data for DNHD1 Gene at MOPED

Post-translational modifications for DNHD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DNHD1 Gene

Domains & Families for DNHD1 Gene

Protein Domains for DNHD1 Gene

Suggested Antigen Peptide Sequences for DNHD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96M86

UniProtKB/Swiss-Prot:

DNHD1_HUMAN :
  • Belongs to the dynein heavy chain family.
Family:
  • Belongs to the dynein heavy chain family.
genes like me logo Genes that share domains with DNHD1: view

No data available for Gene Families for DNHD1 Gene

Function for DNHD1 Gene

genes like me logo Genes that share phenotypes with DNHD1: view

Animal Model Products

CRISPR Products

miRNA for DNHD1 Gene

miRTarBase miRNAs that target DNHD1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNHD1 Gene

Localization for DNHD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNHD1 Gene COMPARTMENTS Subcellular localization image for DNHD1 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 2
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DNHD1 Gene

Pathways & Interactions for DNHD1 Gene

SuperPathways for DNHD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNHD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DNHD1 Gene

Drugs & Compounds for DNHD1 Gene

No Compound Related Data Available

Transcripts for DNHD1 Gene

Unigene Clusters for DNHD1 Gene

Dynein heavy chain domain 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNHD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: -
SP2:
SP3: - - -
SP4:
SP5:
SP6: -

Relevant External Links for DNHD1 Gene

GeneLoc Exon Structure for
DNHD1
ECgene alternative splicing isoforms for
DNHD1

Expression for DNHD1 Gene

mRNA expression in normal human tissues for DNHD1 Gene

mRNA differential expression in normal tissues according to GTEx for DNHD1 Gene

This gene is overexpressed in Testis (x6.3).

Protein differential expression in normal tissues from HIPED for DNHD1 Gene

This gene is overexpressed in Prostate (59.8) and Fetal Brain (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DNHD1 Gene



SOURCE GeneReport for Unigene cluster for DNHD1 Gene Hs.720080

genes like me logo Genes that share expression patterns with DNHD1: view

Protein tissue co-expression partners for DNHD1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DNHD1 Gene

Orthologs for DNHD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DNHD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNHD1 35
  • 81.44 (n)
  • 74.98 (a)
DNHD1 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNHD1 35
  • 83.59 (n)
  • 77.99 (a)
DNHD1 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnhd1 35
  • 77.63 (n)
  • 69.64 (a)
Dnhd1 16
Dnhd1 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnhd1-ps1 35
  • 77.09 (n)
  • 69.13 (a)
oppossum
(Monodelphis domestica)
Mammalia DNHD1 36
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 45 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
-- 36
  • 40 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia DNHD1 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dnhd1 35
  • 46.44 (n)
  • 34.19 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101882863 35
  • 43.08 (n)
  • 29.48 (a)
DNHD1 36
  • 24 (a)
OneToOne
Species with no ortholog for DNHD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNHD1 Gene

ENSEMBL:
Gene Tree for DNHD1 (if available)
TreeFam:
Gene Tree for DNHD1 (if available)

Paralogs for DNHD1 Gene

(2) SIMAP similar genes for DNHD1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with DNHD1: view

No data available for Paralogs for DNHD1 Gene

Variants for DNHD1 Gene

Sequence variations from dbSNP and Humsavar for DNHD1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_033353 -
VAR_033354 -
VAR_033355 -
VAR_037388 -
VAR_037389 -

Structural Variations from Database of Genomic Variants (DGV) for DNHD1 Gene

Variant ID Type Subtype PubMed ID
nsv515990 CNV Loss 19592680
esv25728 CNV Loss 19812545
esv2661307 CNV Deletion 23128226

Variation tolerance for DNHD1 Gene

Gene Damage Index Score: 26.79; 99.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNHD1 Gene

HapMap Linkage Disequilibrium report
DNHD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNHD1 Gene

Disorders for DNHD1 Gene

Relevant External Links for DNHD1

Genetic Association Database (GAD)
DNHD1
Human Genome Epidemiology (HuGE) Navigator
DNHD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNHD1

No disorders were found for DNHD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNHD1 Gene

Publications for DNHD1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3
  3. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3
  4. GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association. (PMID: 23725790) RenterA-a M.E. … Medland S.E. (Twin Res Hum Genet 2013) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for DNHD1 Gene

Sources for DNHD1 Gene

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