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Aliases for DNER Gene

Aliases for DNER Gene

  • Delta/Notch Like EGF Repeat Containing 2 3 5
  • Delta/Notch-Like EGF Repeat Containing 2 3
  • Bet 3 4
  • Delta-Notch-Like EGF Repeat-Containing Transmembrane 3
  • WUGSC:H_NH0150O02.1 3
  • H_NH0150O02.1 3
  • UNQ26 3

External Ids for DNER Gene

Previous GeneCards Identifiers for DNER Gene

  • GC02M228282
  • GC02M228954
  • GC02M230186
  • GC02M230424
  • GC02M230047
  • GC02M229930
  • GC02M222063

Summaries for DNER Gene

GeneCards Summary for DNER Gene

DNER (Delta/Notch Like EGF Repeat Containing) is a Protein Coding gene. Among its related pathways are NOTCH2 Activation and Transmission of Signal to the Nucleus and Notch Signaling Pathways. GO annotations related to this gene include calcium ion binding and clathrin binding. An important paralog of this gene is NOTCH2NL.

UniProtKB/Swiss-Prot for DNER Gene

  • Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).

Gene Wiki entry for DNER Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNER Gene

Genomics for DNER Gene

Regulatory Elements for DNER Gene

Enhancers for DNER Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DNER on UCSC Golden Path with GeneCards custom track

Promoters for DNER Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DNER on UCSC Golden Path with GeneCards custom track

Genomic Location for DNER Gene

229,357,629 bp from pter
229,714,570 bp from pter
356,942 bases
Minus strand

Genomic View for DNER Gene

Genes around DNER on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNER Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNER Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNER Gene

Proteins for DNER Gene

  • Protein details for DNER Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Delta and Notch-like epidermal growth factor-related receptor
    Protein Accession:
    Secondary Accessions:
    • A6NP39
    • Q53R88
    • Q53TP7
    • Q53TQ5
    • Q8IYT0
    • Q8TB42
    • Q9NTF1
    • Q9UDM2

    Protein attributes for DNER Gene

    737 amino acids
    Molecular mass:
    78475 Da
    Quaternary structure:
    • Interacts with AP1G1. Interacts with NOTCH1 (By similarity).

neXtProt entry for DNER Gene

Proteomics data for DNER Gene at MOPED

Post-translational modifications for DNER Gene

  • Glycosylation at Thr 177, Asn 223, and Asn 564
  • Modification sites at PhosphoSitePlus

Other Protein References for DNER Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DNER Gene

Domains & Families for DNER Gene

Suggested Antigen Peptide Sequences for DNER Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 10 EGF-like domains.
  • Contains 10 EGF-like domains.
  • Contains 1 follistatin-like domain.
genes like me logo Genes that share domains with DNER: view

No data available for Gene Families for DNER Gene

Function for DNER Gene

Molecular function for DNER Gene

UniProtKB/Swiss-Prot Function:
Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for DNER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA,NAS 11950833
genes like me logo Genes that share ontologies with DNER: view

Phenotypes for DNER Gene

genes like me logo Genes that share phenotypes with DNER: view

Animal Models for DNER Gene

MGI Knock Outs for DNER:

Animal Model Products

  • Taconic Biosciences Mouse Models for DNER

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DNER Gene

Localization for DNER Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNER Gene

Cell membrane; Single-pass type I membrane protein. Note=Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for DNER Gene COMPARTMENTS Subcellular localization image for DNER gene
Compartment Confidence
endosome 5
plasma membrane 5
extracellular 3
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for DNER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030425 dendrite IEA,IDA 11950833
genes like me logo Genes that share ontologies with DNER: view

Pathways & Interactions for DNER Gene

genes like me logo Genes that share pathways with DNER: view

Pathways by source for DNER Gene

1 R&D Systems pathway for DNER Gene

SIGNOR curated interactions for DNER Gene


Gene Ontology (GO) - Biological Process for DNER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007219 Notch signaling pathway IEA,TAS --
GO:0007220 Notch receptor processing IEA --
GO:0007416 synapse assembly NAS 11950833
GO:0010001 glial cell differentiation IEA --
genes like me logo Genes that share ontologies with DNER: view

Drugs & Compounds for DNER Gene

No Compound Related Data Available

Transcripts for DNER Gene

mRNA/cDNA for DNER Gene

Unigene Clusters for DNER Gene

Delta/notch-like EGF repeat containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNER Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: -
SP3: - -
SP4: -

Relevant External Links for DNER Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNER Gene

mRNA expression in normal human tissues for DNER Gene

mRNA differential expression in normal tissues according to GTEx for DNER Gene

This gene is overexpressed in Brain - Hypothalamus (x6.2), Brain - Substantia nigra (x5.6), and Brain - Spinal cord (cervical c-1) (x4.3).

Protein differential expression in normal tissues from HIPED for DNER Gene

This gene is overexpressed in Cerebrospinal fluid (27.3), Vitreous humor (18.6), and Fetal Brain (17.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNER Gene

SOURCE GeneReport for Unigene cluster for DNER Gene Hs.234074

mRNA Expression by UniProt/SwissProt for DNER Gene

Tissue specificity: Expressed in brain, spinal cord and adrenal gland.
genes like me logo Genes that share expression patterns with DNER: view

Protein tissue co-expression partners for DNER Gene

- Elite partner

Primer Products

Orthologs for DNER Gene

This gene was present in the common ancestor of animals.

Orthologs for DNER Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DNER 35
  • 87.81 (n)
  • 90.28 (a)
  • 91 (a)
(Canis familiaris)
Mammalia DNER 35
  • 89.25 (n)
  • 93.52 (a)
  • 92 (a)
(Mus musculus)
Mammalia Dner 35
  • 87.43 (n)
  • 90.5 (a)
Dner 16
Dner 36
  • 91 (a)
(Pan troglodytes)
Mammalia DNER 35
  • 99.37 (n)
  • 99.73 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Dner 35
  • 87.2 (n)
  • 91.32 (a)
(Ornithorhynchus anatinus)
Mammalia DNER 36
  • 86 (a)
(Gallus gallus)
Aves DNER 35
  • 75.18 (n)
  • 77.04 (a)
  • 66 (a)
(Anolis carolinensis)
Reptilia DNER 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dner 35
  • 69.34 (n)
  • 72.84 (a)
Str.12208 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.17677 35
(Danio rerio)
Actinopterygii dner 35
  • 62.67 (n)
  • 59.04 (a)
dner 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta wry 36
  • 17 (a)
Species with no ortholog for DNER:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNER Gene

Gene Tree for DNER (if available)
Gene Tree for DNER (if available)

Paralogs for DNER Gene

genes like me logo Genes that share paralogs with DNER: view

Variants for DNER Gene

Sequence variations from dbSNP and Humsavar for DNER Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs17853365 - 229,447,504(+) CGCAG(A/G)GGTCC reference, missense
rs719946 -- 229,618,771(+) AAATA(A/G)AATGA intron-variant
rs720915 -- 229,453,697(+) ACCCT(G/T)TCTGC intron-variant
rs720916 -- 229,453,346(+) tgcta(A/G)gggag intron-variant
rs721528 -- 229,690,484(+) GCCCA(A/G)TGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNER Gene

Variant ID Type Subtype PubMed ID
nsv834564 CNV Gain 17160897
nsv3198 CNV Insertion 18451855
esv273242 CNV Insertion 20981092
esv268917 CNV Insertion 20981092
nsv875939 CNV Gain 21882294
esv2669440 CNV Deletion 23128226
nsv520821 CNV Loss 19592680
nsv875940 CNV Loss 21882294
esv25345 CNV Loss 19812545
esv269313 CNV Insertion 20981092
nsv522560 CNV Loss 19592680
esv2290408 CNV Deletion 18987734
esv2652970 CNV Deletion 19546169
esv2721589 CNV Deletion 23290073
esv2664843 CNV Deletion 23128226
esv2751841 CNV Gain 17911159

Variation tolerance for DNER Gene

Residual Variation Intolerance Score: 53.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.20% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DNER Gene

Disorders for DNER Gene

Relevant External Links for DNER

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DNER Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNER Gene

Publications for DNER Gene

  1. Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons. (PMID: 11950833) Eiraku M. … Kengaku M. (J. Biol. Chem. 2002) 2 3 4 67
  2. BET, a novel neuronal transmembrane protein with multiple EGF-like motifs. (PMID: 11997712) Nishizumi H. … Sakano H. (NeuroReport 2002) 2 3
  3. A genome-wide association study in American Indians implicates DNER as a susceptibility locus for type 2 diabetes. (PMID: 24101674) Hanson R.L. … Baier L.J. (Diabetes 2014) 3
  4. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3
  5. Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1. (PMID: 23383108) Denner J. … AkyA1z L. (PLoS ONE 2013) 3

Products for DNER Gene

Sources for DNER Gene