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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DNER Gene

protein-coding GIFtS: 52
GCID: GC02M230186

delta/notch-like EGF repeat containing

Explore 4 diseases affiliated with
DNER via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Delta/Notch-Like EGF Repeat Containing¹ ²		WUGSC:H_NH0150O02.1²
UNQ26¹ ²		Delta And Notch-Like Epidermal Growth Factor-Related Receptor²
Bet¹		Delta-Notch-Like EGF Repeat-Containing Transmembrane²
H_NH0150O02.1²		BET³

External Ids:	HGNC: 24456¹	Entrez Gene: 92737²	Ensembl: ENSG00000187957⁷	OMIM: 607299⁵	UniProtKB: Q8NFT8³

Export aliases for DNER gene to outside databases

Previous GC identifers: GC02M228282 GC02M228954 GC02M230424 GC02M230047 GC02M229930 GC02M222063

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DNER_HUMAN, Q8NFT8

Function: Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity)

Gene Wiki entry for DNER

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DNER gene promoter:
AP-1 NRSF form 1 ATF-2 MyoD AP-4 NRSF form 2 c-Jun ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DNER promoter sequence

Search SABiosciences Chromatin IP Primers for DNER

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNER

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.3 Ensembl cytogenetic band: 2q36.3 HGNC cytogenetic band: 2q36.3

DNER Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNER gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M230186: view genomic region (about GC identifiers)

Start:	230,222,345 bp from pter	End:	230,579,286 bp from pter
Size:	356,942 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DNER_HUMAN, Q8NFT8 (See protein sequence)

Recommended Name: Delta and Notch-like epidermal growth factor-related receptor precursor

Size: 737 amino acids; 78475 Da

Subunit: Interacts with AP1G1. Interacts with NOTCH1 (By similarity)

Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=Present on the membrane of dendrites and

cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region (By

similarity)

Secondary accessions: A6NP39 Q53R88 Q53TP7 Q53TQ5 Q8IYT0 Q8TB42 Q9NTF1 Q9UDM2

Explore the universe of human proteins at neXtProt for DNER: NX_Q8NFT8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NFT8

DNER Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_620711.3

ENSEMBL proteins:

ENSP00000345229

Reactome Protein details: Q8NFT8
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for DNER
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	GenScript Custom Purified and Recombinant Proteins Services for DNER
	Novus Biologicals DNER Protein Novus Biologicals DNER Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005769	early endosome	IDA	11950833
GO:0005886	plasma membrane	IDA	11950833
GO:0016021	integral to membrane	IEA	--
GO:0030425	dendrite	IDA	11950833
GO:0043025	neuronal cell body	IEA	--

DNER for ontologies About GeneDecksing

DNER Antibody Products:

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	Novus Biologicals DNER Antibodies
	Search for Antibodies for DNER at Abcam
	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for DNER

Assay Products for DNER:

	Browse Kits and Assays available from EMD Millipore
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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DNER for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR001881 EGF-like_Ca-bd

IPR000742 EG-like_dom

IPR013032 EGF-like_CS

IPR000152 EGF-type_Asp/Asn_hydroxyl_site

IPR018097 EGF_Ca-bd_CS

Graphical View of Domain Structure for InterPro Entry Q8NFT8

ProtoNet protein and cluster: Q8NFT8

2 Blocks protein families:

IPB000152 Aspartic acid and asparagine hydroxylation site

IPB001881 EGF-like calcium-binding

UniProtKB/Swiss-Prot: DNER_HUMAN, Q8NFT8

Similarity: Contains 10 EGF-like domains

Similarity: Contains 1 follistatin-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DNER_HUMAN, Q8NFT8

Function: Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: DNER Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DNER
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate DNER:
		hsa-miR-320a hsa-miR-320b hsa-miR-539 hsa-miR-513a-3p hsa-miR-618 hsa-miR-320d hsa-miR-3647-3p hsa-miR-646

		SwitchGear 3'UTR luciferase reporter plasmid: DNER 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNER (see all 4) OriGene shRNA RFP: DNER OriGene siRNA: DNER
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNER

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DNER

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNER (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNER OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DNER (NM_139072)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNER
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNER

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DNER
		Search LifeMap BioReagents cell lines for DNER

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNER

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane signaling receptor activity	TAS	11950833
GO:0005112	Notch binding	IEA	--
GO:0005509	calcium ion binding	NAS	11950833
GO:0005515	protein binding	IPI	11950833
GO:0030276	clathrin binding	TAS	11950833

DNER for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Dner^tm1Hta for DNER
     2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dner):

behavior/neurological

nervous system

DNER for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant

Signaling by NOTCH1 PEST Domain Mutants in Cancer	1.00	FBXW7 Mutants and NOTCH1 in Cancer	1.00
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	1.00	Signaling by NOTCH1	1.00
Signaling by NOTCH1 in Cancer	1.00	Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant	1.00
Signaling by NOTCH1 HD Domain Mutants in Cancer	1.00	Signaling by NOTCH	0.77

Cleavage of DNER:NOTCH1 complex releases NICD1

Cleavage of DNER:NOTCH1 complex releases NICD1

1.00

Disease

Disease

1.00

Notch signaling pathway

Notch signaling pathway

1.00

NOTCH2 Activation and Transmission of Signal to the Nucleus

Activated NOTCH1 Transmits Signal to the Nucleus

0.58

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for DNER

Notch signaling pathway

5/12 Reactome Pathways for DNER (see all 12)

	Signaling by NOTCH
	FBXW7 Mutants and NOTCH1 in Cancer
	Signaling by NOTCH1 HD Domain Mutants in Cancer
	Signaling by NOTCH1 in Cancer
	Disease

DNER for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DNER

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/9 Interacting proteins for DNER (Q8NFT8³ ENSP00000345229⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AP1G1	O43747³, ENSP00000377148⁴	I2D: score=1 STRING: ENSP00000377148
ZNF24	P17028³	I2D: score=1
DTX1	ENSP00000257600⁴	STRING: ENSP00000257600
NOTCH1	ENSP00000277541⁴	STRING: ENSP00000277541
APH1A	ENSP00000358105⁴	STRING: ENSP00000358105

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001764	neuron migration	NAS	11950833
GO:0006897	endocytosis	NAS	11950833
GO:0007219	Notch signaling pathway	TAS	--
GO:0007220	Notch receptor processing	IEA	--
GO:0007416	synapse assembly	NAS	11950833

DNER for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DNER
Search CenterWatch for drugs/clinical trials and news about DNER

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DNER gene:

NM_139072.3

Unigene Cluster for DNER:

Delta/notch-like EGF repeat containing

Hs.234074 [show with all ESTs]

Unigene Representative Sequence: BC035009

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000341772(uc010zly.1 uc002vpv.3) ENST00000482831

miRNA Products:		OriGene 3'-UTR Clone: DNER Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DNER
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate DNER:
		hsa-miR-320a hsa-miR-320b hsa-miR-539 hsa-miR-513a-3p hsa-miR-618 hsa-miR-320d hsa-miR-3647-3p hsa-miR-646

		SwitchGear 3'UTR luciferase reporter plasmid: DNER 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNER (see all 4) OriGene shRNA RFP: DNER OriGene siRNA: DNER
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNER

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNER (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNER OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DNER (NM_139072)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNER
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNER

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNER Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DNER
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNER
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNER

Additional cDNA sequence:

AF442487.1 AK289553.1 AK304596.1 AK304631.1 AK308576.1 AL137311.1 AY358891.1 BC024766.2

BC035009.1

6 DOTS entries:

DT.113110 DT.100782293 DT.100782295 DT.91996524 DT.95091427 DT.95091432

24/133 AceView cDNA sequences (see all 133):

AI636555 CD105614 AI394531 AI203048 AI631197 AV729301 BM723384 AI468746

AA321164 AA321911 AW006208 CD108656 AI912956 AW952293 AI479888 AI476160

BQ774774 AI968200 AW007504 AL137311 BU742167 CD251620 BQ637164 AW051673

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DNER (see all 6) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15
SP1:																															-
SP2:
SP3:																									-						-
SP4:									-
SP5:

ECgene alternative splicing isoforms for DNER

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DNER expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTAAGTAAC

About this image

DNER expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Endothelial Cells

Blood Brain Barrier, Endothelium

Eye

Retina

Eye

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 8 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

Ventral/hypothalamic-like neurons (Generation of midbra...)

See DNER Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DNER

SOURCE GeneReport for Unigene cluster: Hs.234074

UniProtKB/Swiss-Prot: DNER_HUMAN, Q8NFT8

Tissue specificity: Expressed in brain, spinal cord and adrenal gland

SABiosciences Custom PCR Arrays for DNER

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNER Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DNER
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNER
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNER

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNER

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DNER gene from 5/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DNER¹	delta/notch-like EGF repeat containing	75.01(n) 76.65(a)		424786 XM_422604.3 XP_422604.2
lizard (Anolis carolinensis)	Reptilia	DNER⁶ NOTCH1⁶	--	78(a) 11(a)	1 ↔ 1 possible ortholog	3(22616798-22687623) AAWZ02036232(2523-29071)
African clawed frog (Xenopus laevis)	Amphibia	Xl.17677²	Xenopus laevis transcribed sequence with weak similarity more	71.13(n)		CD326434.1
zebrafish (Danio rerio)	Actinopterygii	dner¹	delta/notch-like EGF repeat containing	63.36(n) 60.15(a)		100332110 XM_002665411.2 XP_002665457.2
honey bee (Apis mellifera)	Insecta	--	--	6(a)	1 ↔ 1	Group3.3(29732-48586)

ENSEMBL Gene Tree for DNER (if available)
TreeFam Gene Tree for DNER (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DNER gene

NOTCH4² SNED1² NOTCH1² NOTCH3² DLL3² DLL4² JAG2² CRB2²

NOTCH2² JAG1² CRB1² DLL1²

DNER for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143360352^1,2	C,	other	230456445(+)	`GGATTC/TGGTCC`	2	K E	mis¹		0	--	--	--	--
rs10712357^1,2	C,	--	222124440(+)	`ATCTC-/AAAAAA`	1	--	int¹ trp³		2		NA CSA	4
rs144641479^1,2		--	230221879(+)	`CTGAAC/TATAGG`	1	--	ds500¹		0	--	--	--	--
rs60749704^1,2	C,	--	230221897(+)	`TAAACG/AGCCTT`	1	--	ds500¹		2		WA	120
rs138684613^1,2		--	230221920(+)	`AACCAC/TGGAGC`	1	--	ds500¹		0	--	--	--	--
rs34689433^1,2	C,F,	--	230221952(+)	`TTAGCC/TTCCAC`	1	--	ds500¹		10		NA CSA WA EA	372
rs113351307^1,2		--	230222021(+)	`GCCTGC/ACCTCA`	1	--	ds500¹		1		CSA	2
rs115307357^1,2	C,F,	--	230222119(+)	`AAGAAT/CTCTTA`	1	--	ds500¹		1		WA	118
rs12476803^1,2	C,H	--	230222156(+)	`AGCAGC/TTAGGG`	1	--	ds500¹		2		NS NA	182
rs150349952^1,2		--	230222276(+)	`GGATTC/GTTTGG`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DNER (230222345 - 230472345 bp, first 250kb of DNER)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for DNER
9 CNVs: 8396 68240 4329 79007 90327 90328 50410 98163 79006

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNER

DNA2.0 Custom Variant and Variant Library Synthesis for DNER

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DNER for disorders           About GeneDecksing

OMIM gene information: 607299    OMIM disorders: --

4 diseases for DNER:    About MalaCards

pathological gambling hepatitis b hepatitis neuronitis

Human Genome Epidemiology (HuGE) Navigator: DNER (1 document)

Export disorders for DNER gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DNER gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with DNER)

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Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons. (PubMed id 11950833)^{1, 2, 3} Eiraku M.... Kengaku M. (2002)
BET, a novel neuronal transmembrane protein with multiple EGF-like motifs. (PubMed id 11997712)^{1, 2, 3} Nishizumi H.... Sakano H. (2002)
Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)^{1, 2} Ramachandran P....Loo J.A. (2006)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (2010)
Polarized targeting of DNER into dendritic plasma mem brane in hippocampal neurons depends on endocytosis. (PubMed id 20367751)¹ Kurisu J....Kengaku M. (2010)
DNER modulates adipogenesis of human adipose tissue-d erived mesenchymal stem cells via regulation of cell proliferation. (PubMed id 20070733)¹ Park J.R....Kang K.S. (2010)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 92737	HGNC: 24456	AceView: DNER	Ensembl:ENSG00000187957	euGenes: HUgn92737
ECgene: DNER	H-InvDB: DNER

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DNER	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DNER gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DNER gene:
Search GeneIP for patents involving DNER

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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delta/notch-like EGF repeat containing

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DNER Gene

delta/notch-like EGF repeat containing

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