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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DNER Gene

protein-coding   GIFtS: 54
GCID: GC02M230186

Delta/Notch-Like EGF Repeat Containing

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Delta/Notch-Like EGF Repeat Containing1 2     bet2
H_NH0150O02.12     Delta And Notch-Like Epidermal Growth Factor-Related Receptor2
UNQ262     Delta-Notch-Like EGF Repeat-Containing Transmembrane2
WUGSC:H_NH0150O02.12     BET3

External Ids:    HGNC: 244561   Entrez Gene: 927372   Ensembl: ENSG000001879577   OMIM: 6072995   UniProtKB: Q8NFT83   

Export aliases for DNER gene to outside databases

Previous GC identifers: GC02M228282 GC02M228954 GC02M230424 GC02M230047 GC02M229930 GC02M222063


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DNER Gene: 
DNER (delta/notch-like EGF repeat containing) is a protein-coding gene. Diseases associated with DNER include pathological gambling, and hepatitis b, and among its related super-pathways are Constitutive Signaling by NOTCH1 PEST Domain Mutants and NOTCH2 Activation and Transmission of Signal to the Nucleus. GO annotations related to this gene include clathrin binding and calcium ion binding. An important paralog of this gene is DLK2.

UniProtKB/Swiss-Prot: DNER_HUMAN, Q8NFT8
Function: Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By
similarity)

Gene Wiki entry for DNER Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DNER gene promoter:
         AP-1   NRSF form 1   ATF-2   MyoD   AP-4   NRSF form 2   c-Jun   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNER promoter sequence
   Search SABiosciences Chromatin IP Primers for DNER

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNER


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.3   Ensembl cytogenetic band:  2q36.3   HGNC cytogenetic band: 2q36.3

DNER Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNER gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M230186:  view genomic region     (about GC identifiers)

Start:
230,222,345 bp from pter      End:
230,579,286 bp from pter
Size:
356,942 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DNER_HUMAN, Q8NFT8 (See protein sequence)
Recommended Name: Delta and Notch-like epidermal growth factor-related receptor precursor  
Size: 737 amino acids; 78475 Da
Subunit: Interacts with AP1G1. Interacts with NOTCH1 (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=Present on the membrane of
dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic
region (By similarity)
Secondary accessions: A6NP39 Q53R88 Q53TP7 Q53TQ5 Q8IYT0 Q8TB42 Q9NTF1 Q9UDM2

Explore the universe of human proteins at neXtProt for DNER: NX_Q8NFT8

Explore proteomics data for DNER at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NFT8

  • DNER Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DNER Protein Expression
    REFSEQ proteins: NP_620711.3  
    ENSEMBL proteins: 
     ENSP00000345229  
    Reactome Protein details: Q8NFT8
    Human Recombinant Protein Products for DNER: 
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    Novus Biologicals DNER Protein
    Novus Biologicals DNER Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome IDA11950833
    GO:0005886plasma membrane IDA11950833
    GO:0016021integral to membrane IEA--
    GO:0030425dendrite IDA11950833
    GO:0043025neuronal cell body IEA--

    DNER for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS
     IPR001881 EGF-like_Ca-bd
     IPR000742 EG-like_dom
     IPR003645 Fol_N

    Graphical View of Domain Structure for InterPro Entry Q8NFT8

    ProtoNet protein and cluster: Q8NFT8

    2 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001881 EGF-like calcium-binding


    UniProtKB/Swiss-Prot: DNER_HUMAN, Q8NFT8
    Similarity: Contains 10 EGF-like domains
    Similarity: Contains 1 follistatin-like domain


    DNER for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DNER_HUMAN, Q8NFT8
    Function: Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By
    similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS11950833
    GO:0005112Notch binding IEA--
    GO:0005509calcium ion binding NAS11950833
    GO:0005515protein binding IPI11950833
    GO:0030276clathrin binding TAS11950833
         
    DNER for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dner):
     behavior/neurological  nervous system 

    DNER for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dnertm1Hta for DNER

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DNER 
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    hsa-miR-320a hsa-miR-320b hsa-miR-539 hsa-miR-513a-3p hsa-miR-618 hsa-miR-320d hsa-miR-3647-3p hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidDNER 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DNER About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant
    Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 HD Domain Mutants in Cancer0.79
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 in Cancer0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH10.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH0.74
    2NOTCH2 intracellular domain regulates transcription
    Activated NOTCH1 Transmits Signal to the Nucleus0.59
    3Signaling by GPCR
    Signal Transduction0.55
    4Notch signaling pathway
    Notch signaling pathway
    5Notch Signaling Pathways
    Notch Signaling Pathways

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for DNER
        Notch Signaling Pathways


    1 BioSystems Pathway for DNER
        Notch signaling pathway

    5/11        Reactome Pathways for DNER (see all 11)
        Signaling by NOTCH
    FBXW7 Mutants and NOTCH1 in Cancer
    Signaling by NOTCH1 HD Domain Mutants in Cancer
    Signaling by NOTCH1 in Cancer
    Disease



    DNER for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNER

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for DNER (Q8NFT83 ENSP000003452294) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AP1G1O437473, ENSP000003771484I2D: score=1 STRING: ENSP00000377148
    ZNF24P170283I2D: score=1 
    DTX1ENSP000002576004STRING: ENSP00000257600
    NOTCH1ENSP000002775414STRING: ENSP00000277541
    APH1AENSP000003581054STRING: ENSP00000358105
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration NAS11950833
    GO:0006897endocytosis NAS11950833
    GO:0007219Notch signaling pathway TAS--
    GO:0007220Notch receptor processing IEA--
    GO:0007416synapse assembly NAS11950833

    DNER for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DNER

    Search CenterWatch for drugs/clinical trials and news about DNER

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DNER gene: 
    NM_139072.3  

    Unigene Cluster for DNER:

    Delta/notch-like EGF repeat containing
    Hs.234074  [show with all ESTs]
    Unigene Representative Sequence: BC035009
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341772(uc010zly.1 uc002vpv.3) ENST00000482831
    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate DNER:
    hsa-miR-320a hsa-miR-320b hsa-miR-539 hsa-miR-513a-3p hsa-miR-618 hsa-miR-320d hsa-miR-3647-3p hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidDNER 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF442487.1 AK289553.1 AK304596.1 AK304631.1 AK308576.1 AL137311.1 AY358891.1 BC024766.2 
    BC035009.1 

    6 DOTS entries:

    DT.113110  DT.100782293  DT.100782295  DT.91996524  DT.95091427  DT.95091432 

    24/133 AceView cDNA sequences (see all 133):

    BI494742 AW268478 AW051673 BC024766 R45443 AI817722 AW005421 BX645399 
    BU743135 AI636555 CD105614 AI394531 AI631197 AI203048 AV729301 BM723384 
    AI468746 AW006208 AA321911 AW952293 AA321164 AI912956 CD108656 AI479888 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DNER (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
    SP1:                                                                                            -                     
    SP2:                                                                                                                  
    SP3:                                                                          -                 -                     
    SP4:                          -                                                                                       
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for DNER

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DNER expression in normal human tissues (normalized intensities)      DNER embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTAAGTAAC
    DNER Expression
    About this image


    DNER expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Endothelial Cells Blood Brain Barrier
             ganglion/cranial/facial VII   
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Retina
             Human Iris Pigment Epithelial Cells (HIPEpiC)   
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Endothelial Cells Blood Brain Barrier
             PureStem endothelial progenitor RP1-MV2-18
     
     Uncategorized (Uncategorized)    fully expand to see all 3 entries
             PureStem progenitor F15
     
     Epithelium
             Human Iris Pigment Epithelial Cells (HIPEpiC)   

    See DNER Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DNER

    SOURCE GeneReport for Unigene cluster: Hs.234074

    UniProtKB/Swiss-Prot: DNER_HUMAN, Q8NFT8
    Tissue specificity: Expressed in brain, spinal cord and adrenal gland

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DNER gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dner1 , 5 delta/notch-like EGF-related receptor1, 5 87.43(n)1
    90.5(a)1
      1 (43.40 cM)5
    2273251  NM_152915.11  NP_690879.11 
     843698415 
    chicken
    (Gallus gallus)
    Aves DNER1 delta/notch-like EGF repeat containing 75.01(n)
    76.65(a)
      424786  XM_422604.3  XP_422604.2 
    lizard
    (Anolis carolinensis)
    Reptilia DNER6
    delta/notch-like EGF repeat containing
    73(a)
    1 ↔ 1
    3(22526473-22687623)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.176772 Xenopus laevis transcribed sequence with weak similarity more 71.13(n)    CD326434.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dner1 delta/notch-like EGF repeat containing 63.36(n)
    60.15(a)
      100332110  XM_002665411.2  XP_002665457.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta eys6
    eyes shut
    7(a)
    1 ↔ 1
    2L(2311680-2358944)


    ENSEMBL Gene Tree for DNER (if available)
    TreeFam Gene Tree for DNER (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DNER gene
    DLK22  SLIT22  SNED12  SLIT12  DLL32  JAG22  DLL42  DLK12  
    JAG12  SLIT32  SVEP12  DLL12  

    DNER for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7933 SNPs in DNER are shown (see all 7933)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1433603521,2
    Cuntested1230456445(+) GGATTC/TGGTCC 2 K E mis10--------
    rs105750421,2
    C--222131964(+) atctc-/A/AA  
            
    aaaaa
    1 -- int10--------
    rs670330651,2
    C--222372345(+) AGACA-/TCCT  
            
    TAATG
    1 -- int10--------
    rs346385591,2
    C--229706251(+) AAAAAA/-TAGTT 1 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs1446414791,2
    --230221879(+) CTGAAC/TATAGG 1 -- ds50010--------
    rs607497041,2
    C,F--230221897(+) TAAACG/AGCCTT 1 -- ds50012Minor allele frequency- A:0.04WA 120
    rs1386846131,2
    --230221920(+) AACCAC/TGGAGC 1 -- ds50010--------
    rs346894331,2
    C,F--230221952(+) TTAGCC/TTCCAC 1 -- ds500110Minor allele frequency- T:0.35NA CSA WA EA 372
    rs1133513071,2
    C,F--230222021(+) GCCTGC/ACCTCA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1153073571,2
    C,F--230222119(+) AAGAAT/CTCTTA 1 -- ds50011Minor allele frequency- C:0.20WA 118

    HapMap Linkage Disequilibrium report for DNER (230222345 - 230472345 bp, first 250kb of DNER)

    Structural Variations
         Database of Genomic Variants (DGV) 10/16 variations for DNER (see all 16):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2290408CNV Deletion18987734
    esv2721589CNV Deletion23290073
    esv2664843CNV Deletion23128226
    esv2652970CNV Deletion19546169
    esv2669440CNV Deletion23128226
    esv273242CNV Insertion20981092
    esv269313CNV Insertion20981092
    esv268917CNV Insertion20981092
    nsv3198CNV Insertion18451855
    nsv522560CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607299    OMIM disorders: --

    4 diseases for DNER:    About MalaCards
    pathological gambling    hepatitis b    hepatitis    neuronitis


    DNER for disorders           About GeneDecksing

    Genetic Association Database (GAD): DNER
    Human Genome Epidemiology (HuGE) Navigator: DNER (1 document)

    Export disorders for DNER gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DNER gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with DNER)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons. (PubMed id 11950833)1, 2, 3 Eiraku M.... Kengaku M. (2002)
    2. BET, a novel neuronal transmembrane protein with multiple EGF-like motifs. (PubMed id 11997712)1, 2, 3 Nishizumi H.... Sakano H. (2002)
    3. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (2006)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. Loci associated with N-glycosylation of human immunogl obulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (2013)
    8. Genome-wide joint meta-analysis of SNP and SNP-by-smok ing interaction identifies novel loci for pulmonary function. (PubMed id 23284291)1 Hancock D.B....London S.J. (2012)
    9. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    10. Polarized targeting of DNER into dendritic plasma mem brane in hippocampal neurons depends on endocytosis. (PubMed id 20367751)1 Kurisu J....Kengaku M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 92737 HGNC: 24456 AceView: DNER Ensembl:ENSG00000187957 euGenes: HUgn92737
    ECgene: DNER H-InvDB: DNER

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DNER Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DNER gene:
    Search GeneIP for patents involving DNER

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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