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DNER Gene

protein-coding   GIFtS: 54
GCID: GC02M230186

Delta/Notch-Like EGF Repeat Containing

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Delta/Notch-Like EGF Repeat Containing1 2     bet2
H_NH0150O02.12     Delta And Notch-Like Epidermal Growth Factor-Related Receptor2
UNQ262     Delta-Notch-Like EGF Repeat-Containing Transmembrane2
WUGSC:H_NH0150O02.12     BET3

External Ids:    HGNC: 244561   Entrez Gene: 927372   Ensembl: ENSG000001879577   OMIM: 6072995   UniProtKB: Q8NFT83   

Export aliases for DNER gene to outside databases

Previous GC identifers: GC02M228282 GC02M228954 GC02M230424 GC02M230047 GC02M229930 GC02M222063


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DNER Gene:
DNER (delta/notch-like EGF repeat containing) is a protein-coding gene. GO annotations related to this gene include clathrin binding and calcium ion binding. An important paralog of this gene is DLK2.

UniProtKB/Swiss-Prot: DNER_HUMAN, Q8NFT8
Function: Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By
similarity)

Gene Wiki entry for DNER Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNER gene promoter:
         AP-1   NRSF form 1   ATF-2   MyoD   AP-4   NRSF form 2   c-Jun   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNER promoter sequence
   Search Chromatin IP Primers for DNER

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNER


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.3   Ensembl cytogenetic band:  2q36.3   HGNC cytogenetic band: 2q36.3

DNER Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNER gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M230186:  view genomic region     (about GC identifiers)

Start:
230,222,345 bp from pter      End:
230,579,286 bp from pter
Size:
356,942 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DNER_HUMAN, Q8NFT8 (See protein sequence)
Recommended Name: Delta and Notch-like epidermal growth factor-related receptor precursor  
Size: 737 amino acids; 78475 Da
Subunit: Interacts with AP1G1. Interacts with NOTCH1 (By similarity)
Secondary accessions: A6NP39 Q53R88 Q53TP7 Q53TQ5 Q8IYT0 Q8TB42 Q9NTF1 Q9UDM2

Explore the universe of human proteins at neXtProt for DNER: NX_Q8NFT8

Explore proteomics data for DNER at MOPED

Post-translational modifications: 

  • Glycosylation2 at Ser169, Thr172, Thr174, Thr177, Asn223, Asn564
  • Modification sites at PhosphoSitePlus

  • See DNER Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_620711.3  
    ENSEMBL proteins: 
     ENSP00000345229  
    Reactome Protein details: Q8NFT8

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    Novus Biologicals DNER Protein
    Novus Biologicals DNER Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for DNER (10 products) 

     
    antibodies-online peptides for DNER

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    antibodies-online antibodies for DNER (40 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR000742 EG-like_dom
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS
     IPR001881 EGF-like_Ca-bd_dom
     IPR009030 Growth_fac_rcpt_N_dom

    Graphical View of Domain Structure for InterPro Entry Q8NFT8

    ProtoNet protein and cluster: Q8NFT8

    2 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001881 EGF-like calcium-binding


    UniProtKB/Swiss-Prot: DNER_HUMAN, Q8NFT8
    Similarity: Contains 10 EGF-like domains
    Similarity: Contains 1 follistatin-like domain


    Find genes that share domains with DNER           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DNER_HUMAN, Q8NFT8
    Function: Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By
    similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS11950833
    GO:0005112Notch binding IEA--
    GO:0005509calcium ion binding NAS11950833
    GO:0005515protein binding IPI11950833
    GO:0030276clathrin binding TAS11950833
         
    Find genes that share ontologies with DNER           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dner):
     behavior/neurological  nervous system 

    Find genes that share phenotypes with DNER           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dnertm1Hta for DNER

       genOway: Develop your customized and physiologically relevant rodent model for DNER

    miRNA
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    hsa-miR-320a hsa-miR-320b hsa-miR-539 hsa-miR-513a-3p hsa-miR-618 hsa-miR-320d hsa-miR-3647-3p hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidDNER 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DNER_HUMAN, Q8NFT8: Cell membrane; Single-pass type I membrane protein. Note=Present on the membrane of
    dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic
    region (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane5
    extracellular2
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome IDA11950833
    GO:0005886plasma membrane IDA11950833
    GO:0016021integral component of membrane IEA--
    GO:0030425dendrite IDA11950833
    GO:0043025neuronal cell body IEA--

    Find genes that share ontologies with DNER           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DNER About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 HD Domain Mutants in Cancer0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH1 in Cancer0.79
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH10.79
    Signaling by NOTCH0.64
    2Signaling by NOTCH2
    Activated NOTCH1 Transmits Signal to the Nucleus0.61
    3Signaling by GPCR
    Signal Transduction0.58
    4Notch Signaling Pathways
    Notch Signaling Pathways
    5Notch signaling pathway (Pathway Interaction Database)
    Notch signaling pathway


    Find genes that share SuperPaths with DNER           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for DNER
        Notch Signaling Pathways


    1 BioSystems Pathway for DNER
        Notch signaling pathway

    1 Reactome Pathway for DNER
        Activated NOTCH1 Transmits Signal to the Nucleus


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DNER
    Interactions:

        Search GeneGlobe Interaction Network for DNER

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for DNER (Q8NFT83 ENSP000003452294) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AP1G1O437473, ENSP000003771484I2D: score=1 STRING: ENSP00000377148
    ZNF24P170283I2D: score=1 
    DTX1ENSP000002576004STRING: ENSP00000257600
    NOTCH1ENSP000002775414STRING: ENSP00000277541
    APH1AENSP000003581054STRING: ENSP00000358105
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration NAS11950833
    GO:0006897endocytosis NAS11950833
    GO:0007219Notch signaling pathway TAS--
    GO:0007220Notch receptor processing IEA--
    GO:0007416synapse assembly NAS11950833

    Find genes that share ontologies with DNER           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNER



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DNER gene: 
    NM_139072.3  

    Unigene Cluster for DNER:

    Delta/notch-like EGF repeat containing
    Hs.234074  [show with all ESTs]
    Unigene Representative Sequence: BC035009
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341772(uc010zly.1 uc002vpv.3) ENST00000482831
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate DNER:
    hsa-miR-320a hsa-miR-320b hsa-miR-539 hsa-miR-513a-3p hsa-miR-618 hsa-miR-320d hsa-miR-3647-3p hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidDNER 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat DNER

    Additional mRNA sequence: 

    AF442487.1 AK289553.1 AK304596.1 AK304631.1 AK308576.1 AL137311.1 AY358891.1 BC024766.2 
    BC035009.1 

    6 DOTS entries:

    DT.113110  DT.100782293  DT.100782295  DT.91996524  DT.95091427  DT.95091432 

    Selected AceView cDNA sequences (see all 133):

    BI494742 AW268478 AW051673 BC024766 R45443 AI817722 AW005421 BX645399 
    BU743135 AI636555 CD105614 AI394531 AI631197 AI203048 AV729301 BM723384 
    AI468746 AW006208 AA321911 AW952293 AA321164 AI912956 CD108656 AI479888 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DNER (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
    SP1:                                                                                            -                     
    SP2:                                                                                                                  
    SP3:                                                                          -                 -                     
    SP4:                          -                                                                                       
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for DNER

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNER expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTAAGTAAC
    DNER Expression
    About this image


    DNER expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Endothelial Cells Blood Brain Barrier
             Ventral/hypothalamic-like neurons
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Corneal Stroma
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 4D20.8, NCr-fac Progenitor
    DNER Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNER Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.234074

    UniProtKB/Swiss-Prot: DNER_HUMAN, Q8NFT8
    Tissue specificity: Expressed in brain, spinal cord and adrenal gland

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DNER gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dner1 , 5 delta/notch-like EGF-related receptor1, 5 87.43(n)1
    90.5(a)1
      1 (43.40 cM)5
    2273251  NM_152915.11  NP_690879.11 
     843698415 
    chicken
    (Gallus gallus)
    Aves DNER1 delta/notch-like EGF repeat containing 75.18(n)
    77.04(a)
      424786  XM_422604.4  XP_422604.2 
    lizard
    (Anolis carolinensis)
    Reptilia DNER6
    delta/notch-like EGF repeat containing
    73(a)
    1 ↔ 1
    3(22526473-22687623)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.176772 Xenopus laevis transcribed sequence with weak similarity more 71.13(n)    CD326434.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dner1 delta/notch-like EGF repeat containing 62.67(n)
    59.04(a)
      100332110  XM_002665411.3  XP_002665457.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta wry6
    weary
    17(a)
    1 → many
    2L(1836630-1858550)


    ENSEMBL Gene Tree for DNER (if available)
    TreeFam Gene Tree for DNER (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNER gene
    DLK22  SNED12  NOTCH42  NOTCH12  DLL32  NOTCH32  JAG22  CRB22  
    DLL42  DLK12  NOTCH22  JAG12  CRB12  DLL12  

    Find genes that share paralogs with DNER           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNER (see all 7933)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1433603521,2
    Cuntested1230456445(+) GGATTC/TGGTCC 2 K E mis10--------
    rs105750421,2
    C--222131964(+) atctc-/A/AA  
            
    aaaaa
    1 -- int10--------
    rs670330651,2
    C--222372345(+) AGACA-/TCCT  
            
    TAATG
    1 -- int10--------
    rs346385591,2
    C--229706251(+) AAAAAA/-TAGTT 1 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs1446414791,2
    --230221879(+) CTGAAC/TATAGG 1 -- ds50010--------
    rs607497041,2
    C,F--230221897(+) TAAACG/AGCCTT 1 -- ds50012Minor allele frequency- A:0.04WA 120
    rs1386846131,2
    --230221920(+) AACCAC/TGGAGC 1 -- ds50010--------
    rs346894331,2
    C,F--230221952(+) TTAGCC/TTCCAC 1 -- ds500110Minor allele frequency- T:0.35NA CSA WA EA 372
    rs1133513071,2
    C,F--230222021(+) GCCTGC/ACCTCA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1153073571,2
    C,F--230222119(+) AAGAAT/CTCTTA 1 -- ds50011Minor allele frequency- C:0.20WA 118

    HapMap Linkage Disequilibrium report for DNER (230222345 - 230472345 bp, first 250kb of DNER)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DNER (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2290408CNV Deletion18987734
    esv2721589CNV Deletion23290073
    esv2664843CNV Deletion23128226
    esv2652970CNV Deletion19546169
    esv2669440CNV Deletion23128226
    esv273242CNV Insertion20981092
    esv269313CNV Insertion20981092
    esv268917CNV Insertion20981092
    nsv3198CNV Insertion18451855
    nsv522560CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 607299    OMIM disorders: --


    Find genes that share disorders with DNER           About GenesLikeMe

    Genetic Association Database (GAD): DNER
    Human Genome Epidemiology (HuGE) Navigator: DNER (1 document)

    Export disorders for DNER gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNER gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with DNER)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons. (PubMed id 11950833)1, 2, 3 Eiraku M.... Kengaku M. (J. Biol. Chem. 2002)
    2. BET, a novel neuronal transmembrane protein with multiple EGF-like motifs. (PubMed id 11997712)1, 2, 3 Nishizumi H.... Sakano H. (NeuroReport 2002)
    3. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (J. Proteome Res. 2006)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. A genome-wide association study in American Indians implicates DNER as a susceptibility locus for type 2 diabetes. (PubMed id 24101674)1 Hanson R.L....Baier L.J. (Diabetes 2014)
    8. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
    9. Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. (PubMed id 23284291)1 Hancock D.B....London S.J. (PLoS Genet. 2012)
    10. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 92737 HGNC: 24456 AceView: DNER Ensembl:ENSG00000187957 euGenes: HUgn92737
    ECgene: DNER H-InvDB: DNER

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DNER Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DNER gene:
    Search GeneIP for patents involving DNER

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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