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Aliases for DND1 Gene

Aliases for DND1 Gene

  • DND MicroRNA-Mediated Repression Inhibitor 1 2 3
  • RNA-Binding Motif, Single-Stranded-Interacting Protein 4 3 4
  • RBMS4 3 4
  • Dead End Homolog 1 (Zebrafish) 2
  • Dead End Protein Homolog 1 3
  • Dead End Homolog 1 3

External Ids for DND1 Gene

Previous GeneCards Identifiers for DND1 Gene

  • GC05U900202
  • GC05M140079
  • GC05M140030
  • GC05M135195

Summaries for DND1 Gene

Entrez Gene Summary for DND1 Gene

  • This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17. [provided by RefSeq, Dec 2010]

GeneCards Summary for DND1 Gene

DND1 (DND MicroRNA-Mediated Repression Inhibitor 1) is a Protein Coding gene. Diseases associated with DND1 include tongue squamous cell carcinoma and testicular germ cell tumor. GO annotations related to this gene include nucleotide binding and miRNA binding. An important paralog of this gene is HNRNPR.

UniProtKB/Swiss-Prot for DND1 Gene

  • RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3 untranslated region (3-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DND1 Gene

Genomics for DND1 Gene

Regulatory Elements for DND1 Gene

Genomic Location for DND1 Gene

Start:
140,670,794 bp from pter
End:
140,673,586 bp from pter
Size:
2,793 bases
Orientation:
Minus strand

Genomic View for DND1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DND1 Gene

Proteins for DND1 Gene

  • Protein details for DND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYX4-DND1_HUMAN
    Recommended name:
    Dead end protein homolog 1
    Protein Accession:
    Q8IYX4
    Secondary Accessions:

    Protein attributes for DND1 Gene

    Size:
    353 amino acids
    Molecular mass:
    38687 Da
    Quaternary structure:
    • Interacts with APOBEC3.

neXtProt entry for DND1 Gene

Proteomics data for DND1 Gene at MOPED

Post-translational modifications for DND1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DND1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DND1 Gene

Domains for DND1 Gene

Gene Families for DND1 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for DND1 Gene

Suggested Antigen Peptide Sequences for DND1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYX4

UniProtKB/Swiss-Prot:

DND1_HUMAN :
  • Q8IYX4
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with DND1: view

Function for DND1 Gene

Molecular function for DND1 Gene

UniProtKB/Swiss-Prot Function: RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3 untranslated region (3-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity).

Gene Ontology (GO) - Molecular Function for DND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0005515 protein binding --
GO:0017091 AU-rich element binding IDA 18155131
GO:0035198 NOT miRNA binding IDA 18155131
genes like me logo Genes that share ontologies with DND1: view
genes like me logo Genes that share phenotypes with DND1: view

miRNA for DND1 Gene

miRTarBase miRNAs that target DND1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DND1 Gene

Localization for DND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DND1 Gene

Nucleus. Cytoplasm. Note=Perinuclear germ granules, also called germ plasm or chromatoid body. Colocalizes in perinuclear sites with APOBEC3 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DND1 Gene COMPARTMENTS Subcellular localization image for DND1 gene
Compartment Confidence
nucleus 5
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18155131
GO:0005737 cytoplasm IDA 18155131
genes like me logo Genes that share ontologies with DND1: view

Pathways for DND1 Gene

SuperPathways for DND1 Gene

No Data Available

Interacting Proteins for DND1 Gene

Gene Ontology (GO) - Biological Process for DND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007281 germ cell development IEA --
GO:0060965 negative regulation of gene silencing by miRNA IDA 18155131
genes like me logo Genes that share ontologies with DND1: view

No data available for Pathways by source for DND1 Gene

Transcripts for DND1 Gene

mRNA/cDNA for DND1 Gene

(26) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DND1 Gene

Dead end homolog 1 (zebrafish):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DND1 Gene

No ASD Table

Relevant External Links for DND1 Gene

GeneLoc Exon Structure for
DND1
ECgene alternative splicing isoforms for
DND1

Expression for DND1 Gene

mRNA expression in normal human tissues for DND1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DND1 Gene

SOURCE GeneReport for Unigene cluster for DND1 Gene Hs.591262

genes like me logo Genes that share expressions with DND1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DND1 Gene

Orthologs for DND1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DND1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DND1 35
  • 99.72 (n)
  • 99.72 (a)
DND1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DND1 35
  • 89.9 (n)
  • 90.08 (a)
DND1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DND1 35
  • 89.14 (n)
  • 89.8 (a)
DND1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnd1 35
  • 84.37 (n)
  • 86.65 (a)
Dnd1 16
Dnd1 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnd1 35
  • 82.95 (n)
  • 86.65 (a)
chicken
(Gallus gallus)
Aves DND1 35
  • 65.28 (n)
  • 57.19 (a)
DND1 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DND1 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnd1 35
  • 54.65 (n)
  • 50.91 (a)
zebrafish
(Danio rerio)
Actinopterygii dnd 36
  • 32 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17838 36
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hrp-2 36
  • 12 (a)
OneToMany
Species with no ortholog for DND1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DND1 Gene

ENSEMBL:
Gene Tree for DND1 (if available)
TreeFam:
Gene Tree for DND1 (if available)

Paralogs for DND1 Gene

Paralogs for DND1 Gene

Selected SIMAP similar genes for DND1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DND1: view

Variants for DND1 Gene

Sequence variations from dbSNP and Humsavar for DND1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs111650695 -- 140,673,253(+) CGGAG(A/G)GGCTG intron-variant
rs139029027 -- 140,673,319(+) CAGGC(C/G)GATGC reference, missense
rs141552022 -- 140,673,353(+) AGCGC(A/C)GCCTT reference, synonymous-codon
rs199564657 -- 140,673,266(+) ACTAC(C/T)GTACC intron-variant
rs199742545 -- 140,672,944(+) GGCGA(C/T)GCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DND1 Gene

Variant ID Type Subtype PubMed ID
nsv471435 CNV Duplication 19718026

Relevant External Links for DND1 Gene

HapMap Linkage Disequilibrium report
DND1
Human Gene Mutation Database (HGMD)
DND1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DND1 Gene

Disorders for DND1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for DND1 Gene including...

Search for DND1 Gene in MalaCards »

(2) University of Copenhagen DISEASES for DND1 Gene

Relevant External Links for DND1

Genetic Association Database (GAD)
DND1
Human Genome Epidemiology (HuGE) Navigator
DND1
genes like me logo Genes that share disorders with DND1: view

No data available for UniProtKB/Swiss-Prot for DND1 Gene

Publications for DND1 Gene

  1. Dead end, a novel vertebrate germ plasm component, is required for zebrafish primordial germ cell migration and survival. (PMID: 12932328) Weidinger G. … Raz E. (Curr. Biol. 2003) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors. (PMID: 18069663) Linger R. … Rapley E.A. (Genes Chromosomes Cancer 2008) 3 48
  4. RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. (PMID: 18155131) Kedde M. … Agami R. (Cell 2007) 3 4
  5. Screening for germline DND1 mutations in testicular cancer patients. (PMID: 20411342) Sijmons R.H. … Hoekstra H.J. (Fam. Cancer 2010) 3 48

Products for DND1 Gene

Sources for DND1 Gene

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