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Aliases for DND1 Gene

Aliases for DND1 Gene

  • DND MicroRNA-Mediated Repression Inhibitor 1 2 3 5
  • RNA-Binding Motif, Single-Stranded-Interacting Protein 4 3 4
  • RBMS4 3 4
  • Dead End Homolog 1 (Zebrafish) 2
  • Dead End Homolog 1 3

External Ids for DND1 Gene

Previous GeneCards Identifiers for DND1 Gene

  • GC05U900202
  • GC05M140079
  • GC05M140030
  • GC05M135195

Summaries for DND1 Gene

Entrez Gene Summary for DND1 Gene

  • This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17. [provided by RefSeq, Dec 2010]

GeneCards Summary for DND1 Gene

DND1 (DND MicroRNA-Mediated Repression Inhibitor 1) is a Protein Coding gene. Diseases associated with DND1 include embryonal testis carcinoma and tongue squamous cell carcinoma. GO annotations related to this gene include nucleic acid binding and AU-rich element binding. An important paralog of this gene is HNRNPR.

UniProtKB/Swiss-Prot for DND1 Gene

  • RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3 untranslated region (3-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DND1 Gene

Genomics for DND1 Gene

Regulatory Elements for DND1 Gene

Promoters for DND1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DND1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DND1 Gene

Chromosome:
5
Start:
140,670,794 bp from pter
End:
140,673,586 bp from pter
Size:
2,793 bases
Orientation:
Minus strand

Genomic View for DND1 Gene

Genes around DND1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DND1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DND1 Gene

Proteins for DND1 Gene

  • Protein details for DND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYX4-DND1_HUMAN
    Recommended name:
    Dead end protein homolog 1
    Protein Accession:
    Q8IYX4

    Protein attributes for DND1 Gene

    Size:
    353 amino acids
    Molecular mass:
    38687 Da
    Quaternary structure:
    • Interacts with APOBEC3.

neXtProt entry for DND1 Gene

Proteomics data for DND1 Gene at MOPED

Post-translational modifications for DND1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DND1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DND1 Gene

Domains & Families for DND1 Gene

Gene Families for DND1 Gene

Protein Domains for DND1 Gene

Suggested Antigen Peptide Sequences for DND1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYX4

UniProtKB/Swiss-Prot:

DND1_HUMAN :
  • Contains 2 RRM (RNA recognition motif) domains.
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with DND1: view

Function for DND1 Gene

Molecular function for DND1 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3 untranslated region (3-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity).

Gene Ontology (GO) - Molecular Function for DND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
genes like me logo Genes that share ontologies with DND1: view
genes like me logo Genes that share phenotypes with DND1: view

Animal Models for DND1 Gene

MGI Knock Outs for DND1:

Animal Model Products

miRNA for DND1 Gene

miRTarBase miRNAs that target DND1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DND1 Gene

Localization for DND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DND1 Gene

Nucleus. Cytoplasm. Note=Perinuclear germ granules, also called germ plasm or chromatoid body. Colocalizes in perinuclear sites with APOBEC3 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DND1 Gene COMPARTMENTS Subcellular localization image for DND1 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for DND1 Gene

Pathways & Interactions for DND1 Gene

SuperPathways for DND1 Gene

No Data Available

Interacting Proteins for DND1 Gene

Gene Ontology (GO) - Biological Process for DND1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DND1 Gene

Drugs & Compounds for DND1 Gene

No Compound Related Data Available

Transcripts for DND1 Gene

mRNA/cDNA for DND1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(26) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DND1 Gene

Dead end homolog 1 (zebrafish):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DND1 Gene

No ASD Table

Relevant External Links for DND1 Gene

GeneLoc Exon Structure for
DND1
ECgene alternative splicing isoforms for
DND1

Expression for DND1 Gene

mRNA expression in normal human tissues for DND1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DND1 Gene

This gene is overexpressed in Spleen (29.6), Liver (25.9), and Prostate (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DND1 Gene



SOURCE GeneReport for Unigene cluster for DND1 Gene Hs.591262

genes like me logo Genes that share expression patterns with DND1: view

Protein tissue co-expression partners for DND1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DND1 Gene

Orthologs for DND1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DND1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DND1 35
  • 89.9 (n)
  • 90.08 (a)
DND1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DND1 35
  • 89.14 (n)
  • 89.8 (a)
DND1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnd1 35
  • 84.37 (n)
  • 86.65 (a)
Dnd1 16
Dnd1 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DND1 35
  • 99.72 (n)
  • 99.72 (a)
DND1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnd1 35
  • 82.95 (n)
  • 86.65 (a)
chicken
(Gallus gallus)
Aves DND1 35
  • 65.28 (n)
  • 57.19 (a)
DND1 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DND1 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnd1 35
  • 54.65 (n)
  • 50.91 (a)
zebrafish
(Danio rerio)
Actinopterygii dnd 36
  • 32 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17838 36
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hrp-2 36
  • 12 (a)
OneToMany
Species with no ortholog for DND1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DND1 Gene

ENSEMBL:
Gene Tree for DND1 (if available)
TreeFam:
Gene Tree for DND1 (if available)

Paralogs for DND1 Gene

Paralogs for DND1 Gene

(3) SIMAP similar genes for DND1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DND1: view

Variants for DND1 Gene

Sequence variations from dbSNP and Humsavar for DND1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs111650695 -- 140,673,253(+) CGGAG(A/G)GGCTG intron-variant
rs139029027 -- 140,673,319(+) CAGGC(C/G)GATGC reference, missense
rs141552022 -- 140,673,353(+) AGCGC(A/C)GCCTT reference, synonymous-codon
rs201389616 -- 140,673,274(+) ACCTG(C/G)GGGTG reference, missense
rs201431369 -- 140,673,258(+) GGGCT(C/G)GGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DND1 Gene

Variant ID Type Subtype PubMed ID
nsv471435 CNV Duplication 19718026

Variation tolerance for DND1 Gene

Gene Damage Index Score: 2.67; 45.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DND1 Gene

HapMap Linkage Disequilibrium report
DND1
Human Gene Mutation Database (HGMD)
DND1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DND1 Gene

Disorders for DND1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DND1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
embryonal testis carcinoma
  • embryonal carcinoma of testis
tongue squamous cell carcinoma
  • squamous-cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search DND1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DND1

Genetic Association Database (GAD)
DND1
Human Genome Epidemiology (HuGE) Navigator
DND1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DND1
genes like me logo Genes that share disorders with DND1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DND1 Gene

Publications for DND1 Gene

  1. Dead end, a novel vertebrate germ plasm component, is required for zebrafish primordial germ cell migration and survival. (PMID: 12932328) Weidinger G. … Raz E. (Curr. Biol. 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The Grainyhead transcription factor Grhl3/Get1 suppresses miR-21 expression and tumorigenesis in skin: modulation of the miR-21 target MSH2 by RNA-binding protein DND1. (PMID: 22614019) Bhandari A. … Andersen B. (Oncogene 2013) 3
  4. APOBEC3 inhibits DEAD-END function to regulate microRNA activity. (PMID: 23890083) Ali S. … Aggarwal S. (BMC Mol. Biol. 2013) 3
  5. Transcripts that associate with the RNA binding protein, DEAD-END (DND1), in embryonic stem (ES) cells. (PMID: 21851623) Zhu R. … Matin A. (BMC Mol. Biol. 2011) 3

Products for DND1 Gene

Sources for DND1 Gene

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