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Aliases for DND1 Gene

Aliases for DND1 Gene

  • DND MicroRNA-Mediated Repression Inhibitor 1 2 3 5
  • RNA-Binding Motif, Single-Stranded-Interacting Protein 4 3 4
  • RBMS4 3 4
  • Dead End Homolog 1 (Zebrafish) 2
  • Dead End Protein Homolog 1 3
  • Dead End Homolog 1 3

External Ids for DND1 Gene

Previous GeneCards Identifiers for DND1 Gene

  • GC05U900202
  • GC05M140079
  • GC05M140030
  • GC05M135195

Summaries for DND1 Gene

Entrez Gene Summary for DND1 Gene

  • This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17. [provided by RefSeq, Dec 2010]

GeneCards Summary for DND1 Gene

DND1 (DND MicroRNA-Mediated Repression Inhibitor 1) is a Protein Coding gene. Diseases associated with DND1 include Tongue Squamous Cell Carcinoma and Embryonal Testis Carcinoma. GO annotations related to this gene include nucleic acid binding and AU-rich element binding. An important paralog of this gene is A1CF.

UniProtKB/Swiss-Prot for DND1 Gene

  • RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3 untranslated region (3-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DND1 Gene

Genomics for DND1 Gene

Regulatory Elements for DND1 Gene

Enhancers for DND1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G140710 1.2 ENCODE 10.9 -37.4 -37398 1.9 CREB3L1 FEZF1 YY1 ZNF143 ZNF263 SP3 TBX21 SSRP1 ZNF610 GLIS1 PCDHA4 HARS HDAC3 PCDHA5 LOC102723915 PCDHA2 PCDHA1 PCDHA10 PCDHA3 IGIP
GH05G140699 1.1 ENCODE 11.3 -27.1 -27101 1.9 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF766 ZNF143 FOS SRA1 WDR55 DND1 EIF4EBP3 ZMAT2 VTRNA1-1 GC05P141994
GH05G140563 1.1 ENCODE 11 +108.7 108660 3.1 HDGF PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A YBX1 ZNF2 CD14 WDR55 DND1 ENSG00000200051 ANKHD1 ANKHD1-EIF4EBP3 ENSG00000253965 IK PFDN1 PCDHB16
GH05G140568 1 Ensembl ENCODE 11.1 +104.2 104231 2.6 PKNOX1 CBFB HLF MNT EBF1 RELA ZKSCAN1 POLR2A GLIS1 IKZF1 CD14 SRA1 TMCO6 EIF4EBP3 WDR55 DND1 ENSG00000200051 ANKHD1 ANKHD1-EIF4EBP3 IK
GH05G140573 0.9 Ensembl ENCODE 11.1 +99.2 99222 1.3 MAX RAD21 FOXA1 NR2F2 GABPA YY1 TEAD3 JUND ZNF316 ATF3 EIF4EBP3 WDR55 DND1 IK NDUFA2 HARS2 APBB3 GC05P142006
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DND1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DND1 Gene

Chromosome:
5
Start:
140,670,794 bp from pter
End:
140,673,586 bp from pter
Size:
2,793 bases
Orientation:
Minus strand

Genomic View for DND1 Gene

Genes around DND1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DND1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DND1 Gene

Proteins for DND1 Gene

  • Protein details for DND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYX4-DND1_HUMAN
    Recommended name:
    Dead end protein homolog 1
    Protein Accession:
    Q8IYX4

    Protein attributes for DND1 Gene

    Size:
    353 amino acids
    Molecular mass:
    38687 Da
    Quaternary structure:
    • Interacts with APOBEC3.

neXtProt entry for DND1 Gene

Post-translational modifications for DND1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DND1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DND1 Gene

Domains & Families for DND1 Gene

Gene Families for DND1 Gene

Suggested Antigen Peptide Sequences for DND1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DND1: view

No data available for UniProtKB/Swiss-Prot for DND1 Gene

Function for DND1 Gene

Molecular function for DND1 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3 untranslated region (3-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity).

Gene Ontology (GO) - Molecular Function for DND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0017091 AU-rich element binding IDA 18155131
GO:0035198 NOT miRNA binding IDA 18155131
genes like me logo Genes that share ontologies with DND1: view
genes like me logo Genes that share phenotypes with DND1: view

Animal Models for DND1 Gene

MGI Knock Outs for DND1:

Animal Model Products

CRISPR Products

miRNA for DND1 Gene

miRTarBase miRNAs that target DND1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DND1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DND1 Gene

Localization for DND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DND1 Gene

Nucleus. Cytoplasm. Note=Perinuclear germ granules, also called germ plasm or chromatoid body. Colocalizes in perinuclear sites with APOBEC3 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DND1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for DND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 18155131
GO:0005737 cytoplasm IDA,IEA 18155131
genes like me logo Genes that share ontologies with DND1: view

Pathways & Interactions for DND1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007281 germ cell development IEA --
GO:0060965 negative regulation of gene silencing by miRNA IDA 18155131
genes like me logo Genes that share ontologies with DND1: view

No data available for Pathways by source and SIGNOR curated interactions for DND1 Gene

Drugs & Compounds for DND1 Gene

No Compound Related Data Available

Transcripts for DND1 Gene

mRNA/cDNA for DND1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(26) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DND1 Gene

Dead end homolog 1 (zebrafish):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DND1

Alternative Splicing Database (ASD) splice patterns (SP) for DND1 Gene

No ASD Table

Relevant External Links for DND1 Gene

GeneLoc Exon Structure for
DND1
ECgene alternative splicing isoforms for
DND1

Expression for DND1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DND1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DND1 Gene

This gene is overexpressed in Spleen (29.6), Liver (25.9), and Prostate (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DND1 Gene



Protein tissue co-expression partners for DND1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DND1 Gene:

DND1

SOURCE GeneReport for Unigene cluster for DND1 Gene:

Hs.591262

Evidence on tissue expression from TISSUES for DND1 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with DND1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DND1 Gene

Orthologs for DND1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DND1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DND1 34 35
  • 99.72 (n)
cow
(Bos Taurus)
Mammalia DND1 34 35
  • 89.9 (n)
dog
(Canis familiaris)
Mammalia DND1 34 35
  • 89.14 (n)
mouse
(Mus musculus)
Mammalia Dnd1 34 16 35
  • 84.37 (n)
rat
(Rattus norvegicus)
Mammalia Dnd1 34
  • 82.95 (n)
chicken
(Gallus gallus)
Aves DND1 34 35
  • 65.28 (n)
lizard
(Anolis carolinensis)
Reptilia DND1 35
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnd1 34
  • 54.65 (n)
zebrafish
(Danio rerio)
Actinopterygii dnd 35
  • 32 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17838 35
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hrp-2 35
  • 12 (a)
OneToMany
Species where no ortholog for DND1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DND1 Gene

ENSEMBL:
Gene Tree for DND1 (if available)
TreeFam:
Gene Tree for DND1 (if available)

Paralogs for DND1 Gene

Paralogs for DND1 Gene

(3) SIMAP similar genes for DND1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DND1: view

Variants for DND1 Gene

Sequence variations from dbSNP and Humsavar for DND1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs387906639 Pathogenic 140,674,776(-) ACAGT(A/C)CTGTG upstream-variant-2KB, reference, missense
rs58302597 Likely benign 140,674,672(+) CACCT(C/T)CCTCA intron-variant, upstream-variant-2KB
rs145532449 Uncertain significance 140,673,945(+) TTGGT(C/G)GTGGG upstream-variant-2KB, utr-variant-3-prime
rs772505507 Uncertain significance 140,674,833(+) GCAGG(A/G)GACAA intron-variant, upstream-variant-2KB
rs77576083 Uncertain significance 140,673,976(+) TGCGG(A/G)GCCCT upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DND1 Gene

Variant ID Type Subtype PubMed ID
nsv471435 CNV gain 19718026
nsv964945 CNV duplication 23825009

Variation tolerance for DND1 Gene

Gene Damage Index Score: 2.67; 45.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DND1 Gene

Human Gene Mutation Database (HGMD)
DND1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DND1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DND1 Gene

Disorders for DND1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DND1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
tongue squamous cell carcinoma
  • carcinoma, squamous cell
embryonal testis carcinoma
  • embryonal carcinoma of testis
- elite association - COSMIC cancer census association via MalaCards
Search DND1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DND1

Genetic Association Database (GAD)
DND1
Human Genome Epidemiology (HuGE) Navigator
DND1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DND1
genes like me logo Genes that share disorders with DND1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DND1 Gene

Publications for DND1 Gene

  1. Dead end, a novel vertebrate germ plasm component, is required for zebrafish primordial germ cell migration and survival. (PMID: 12932328) Weidinger G. … Raz E. (Curr. Biol. 2003) 2 3 4 64
  2. Screening for germline DND1 mutations in testicular cancer patients. (PMID: 20411342) Sijmons R.H. … Hoekstra H.J. (Fam. Cancer 2010) 3 46 64
  3. Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors. (PMID: 18069663) Linger R. … Rapley E.A. (Genes Chromosomes Cancer 2008) 3 46 64
  4. RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. (PMID: 18155131) Kedde M. … Agami R. (Cell 2007) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for DND1 Gene

Sources for DND1 Gene

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