Aliases for DND1 Gene
External Ids for DND1 Gene
Previous GeneCards Identifiers for DND1 Gene
This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17. [provided by RefSeq, Dec 2010]
GeneCards Summary for DND1 Gene
DND1 (DND MicroRNA-Mediated Repression Inhibitor 1) is a Protein Coding gene. Diseases associated with DND1 include tongue squamous cell carcinoma and testicular germ cell tumor. GO annotations related to this gene include nucleotide binding and miRNA binding. An important paralog of this gene is HNRNPR.
UniProtKB/Swiss-Prot for DND1 Gene
RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3 untranslated region (3-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity).