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Aliases for DND1 Gene

Aliases for DND1 Gene

  • DND MicroRNA-Mediated Repression Inhibitor 1 2 3 5
  • RNA-Binding Motif, Single-Stranded-Interacting Protein 4 3 4
  • RBMS4 3 4
  • Dead End Homolog 1 (Zebrafish) 2
  • Dead End Protein Homolog 1 3
  • Dead End Homolog 1 3

External Ids for DND1 Gene

Previous GeneCards Identifiers for DND1 Gene

  • GC05U900202
  • GC05M140079
  • GC05M140030
  • GC05M135195

Summaries for DND1 Gene

Entrez Gene Summary for DND1 Gene

  • This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17. [provided by RefSeq, Dec 2010]

GeneCards Summary for DND1 Gene

DND1 (DND MicroRNA-Mediated Repression Inhibitor 1) is a Protein Coding gene. Diseases associated with DND1 include Tongue Squamous Cell Carcinoma and Embryonal Testis Carcinoma. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and AU-rich element binding. An important paralog of this gene is RBM46.

UniProtKB/Swiss-Prot for DND1 Gene

  • RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3 untranslated region (3-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity).

Additional gene information for DND1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DND1 Gene

Genomics for DND1 Gene

GeneHancer (GH) Regulatory Elements for DND1 Gene

Promoters and enhancers for DND1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I140672 Promoter/Enhancer 0.9 EPDnew Ensembl 550.8 +0.4 393 1.7 POLR2A ZBTB33 SUPT5H DND1 PIR42041 SRA1 PCDHA4 NDUFA2 IK ZMAT2 SLC35A4 APBB3 WDR55
GH05I140563 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11 +108.7 108660 3.1 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A YBX1 ZNF2 YY1 POLR2B SLC35A4 MIR6831 APBB3 CD14 WDR55 DND1 ENSG00000200051 ANKHD1 ANKHD1-EIF4EBP3 ENSG00000253965
GH05I140699 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.3 -27.1 -27101 1.9 HDGF PKNOX1 SMAD1 ARID4B SIN3A ZNF2 YY1 SLC30A9 POLR2B ZNF766 ZMAT2 SRA1 WDR55 DND1 EIF4EBP3 SLC35A4 VTRNA1-1 GC05P142198 GC05P142218
GH05I140710 Promoter/Enhancer 1.6 Ensembl ENCODE 10.9 -37.4 -37398 1.9 CLOCK FEZF1 IRF4 YY1 ZNF213 ZNF143 SP3 SSRP1 ZNF610 GLIS1 VTRNA1-1 LOC105378198 GC05P142198 HARS2 PCDHB18P PURA WDR55 LOC102723915 HDAC3 PCDHGA6
GH05I140573 Enhancer 0.9 Ensembl ENCODE 11.1 +99.2 99221 1.3 FOXA2 MAX RAD21 YY1 TEAD3 ZNF316 RXRA CBFA2T3 REST GABPA EIF4EBP3 WDR55 DND1 NDUFA2 IK HARS2 APBB3 GC05P142210 ENSG00000283155 ENSG00000283602
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DND1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DND1 gene promoter:

Genomic Locations for DND1 Gene

Genomic Locations for DND1 Gene
chr5:140,670,794-140,673,586
(GRCh38/hg38)
Size:
2,793 bases
Orientation:
Minus strand
chr5:140,050,379-140,053,171
(GRCh37/hg19)

Genomic View for DND1 Gene

Genes around DND1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DND1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DND1 Gene

Proteins for DND1 Gene

  • Protein details for DND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYX4-DND1_HUMAN
    Recommended name:
    Dead end protein homolog 1
    Protein Accession:
    Q8IYX4

    Protein attributes for DND1 Gene

    Size:
    353 amino acids
    Molecular mass:
    38687 Da
    Quaternary structure:
    • Interacts with APOBEC3.

neXtProt entry for DND1 Gene

Post-translational modifications for DND1 Gene

No Post-translational modifications

Other Protein References for DND1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DND1 Gene

Domains & Families for DND1 Gene

Gene Families for DND1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DND1 Gene

Suggested Antigen Peptide Sequences for DND1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DND1: view

No data available for UniProtKB/Swiss-Prot for DND1 Gene

Function for DND1 Gene

Molecular function for DND1 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3 untranslated region (3-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity).

Gene Ontology (GO) - Molecular Function for DND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0017091 AU-rich element binding IDA 18155131
GO:0035198 NOT miRNA binding IDA 18155131
genes like me logo Genes that share ontologies with DND1: view
genes like me logo Genes that share phenotypes with DND1: view

Animal Models for DND1 Gene

MGI Knock Outs for DND1:

Animal Model Products

CRISPR Products

miRNA for DND1 Gene

miRTarBase miRNAs that target DND1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DND1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DND1 Gene

Localization for DND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DND1 Gene

Nucleus. Cytoplasm. Note=Perinuclear germ granules, also called germ plasm or chromatoid body. Colocalizes in perinuclear sites with APOBEC3 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DND1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for DND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 18155131
GO:0005737 cytoplasm IEA,IDA 18155131
genes like me logo Genes that share ontologies with DND1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DND1 Gene

Pathways & Interactions for DND1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007281 germ cell development IEA --
GO:0060965 negative regulation of gene silencing by miRNA IDA 18155131
genes like me logo Genes that share ontologies with DND1: view

No data available for Pathways by source and SIGNOR curated interactions for DND1 Gene

Drugs & Compounds for DND1 Gene

No Compound Related Data Available

Transcripts for DND1 Gene

mRNA/cDNA for DND1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(26) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DND1 Gene

Dead end homolog 1 (zebrafish):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DND1

Alternative Splicing Database (ASD) splice patterns (SP) for DND1 Gene

No ASD Table

Relevant External Links for DND1 Gene

GeneLoc Exon Structure for
DND1
ECgene alternative splicing isoforms for
DND1

Expression for DND1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DND1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DND1 Gene

This gene is overexpressed in Spleen (29.6), Liver (25.9), and Prostate (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DND1 Gene



Protein tissue co-expression partners for DND1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DND1 Gene:

DND1

SOURCE GeneReport for Unigene cluster for DND1 Gene:

Hs.591262

Evidence on tissue expression from TISSUES for DND1 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with DND1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DND1 Gene

Orthologs for DND1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DND1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DND1 33 34
  • 99.72 (n)
cow
(Bos Taurus)
Mammalia DND1 33 34
  • 89.9 (n)
dog
(Canis familiaris)
Mammalia DND1 33 34
  • 89.14 (n)
mouse
(Mus musculus)
Mammalia Dnd1 33 16 34
  • 84.37 (n)
rat
(Rattus norvegicus)
Mammalia Dnd1 33
  • 82.95 (n)
chicken
(Gallus gallus)
Aves DND1 33 34
  • 65.28 (n)
lizard
(Anolis carolinensis)
Reptilia DND1 34
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnd1 33
  • 54.65 (n)
zebrafish
(Danio rerio)
Actinopterygii dnd 34
  • 32 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17838 34
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hrp-2 34
  • 12 (a)
OneToMany
Species where no ortholog for DND1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DND1 Gene

ENSEMBL:
Gene Tree for DND1 (if available)
TreeFam:
Gene Tree for DND1 (if available)

Paralogs for DND1 Gene

Paralogs for DND1 Gene

(3) SIMAP similar genes for DND1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DND1: view

Variants for DND1 Gene

Sequence variations from dbSNP and Humsavar for DND1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs145532449 uncertain-significance, Retinitis pigmentosa-deafness syndrome 140,673,945(-) G/C upstream_transcript_variant
rs147372931 benign, Usher syndrome, type 3B 140,674,692(-) G/A/C upstream_transcript_variant
rs150274370 likely-benign, Usher syndrome, type 3B 140,675,107(-) C/T upstream_transcript_variant
rs34732372 benign, Usher syndrome, type 3B 140,675,132(-) G/A upstream_transcript_variant
rs387906639 pathogenic, Usher syndrome, type 3B 140,674,776(-) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DND1 Gene

Variant ID Type Subtype PubMed ID
nsv471435 CNV gain 19718026
nsv964945 CNV duplication 23825009

Variation tolerance for DND1 Gene

Gene Damage Index Score: 2.67; 45.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DND1 Gene

Human Gene Mutation Database (HGMD)
DND1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DND1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DND1 Gene

Disorders for DND1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DND1 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
tongue squamous cell carcinoma
  • carcinoma, squamous cell
embryonal testis carcinoma
  • embryonal carcinoma of testis
- elite association - COSMIC cancer census association via MalaCards
Search DND1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DND1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DND1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DND1 Gene

Publications for DND1 Gene

  1. dead end, a novel vertebrate germ plasm component, is required for zebrafish primordial germ cell migration and survival. (PMID: 12932328) Weidinger G … Raz E (Current biology : CB 2003) 2 3 4 58
  2. Screening for germline DND1 mutations in testicular cancer patients. (PMID: 20411342) Sijmons RH … Hoekstra HJ (Familial cancer 2010) 3 44 58
  3. Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors. (PMID: 18069663) Linger R … Rapley EA (Genes, chromosomes & cancer 2008) 3 44 58
  4. RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. (PMID: 18155131) Kedde M … Agami R (Cell 2007) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for DND1 Gene

  • Addgene plasmids for DND1

Sources for DND1 Gene

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