Aliases for DND1 Gene
External Ids for DND1 Gene
Previous GeneCards Identifiers for DND1 Gene
This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17. [provided by RefSeq, Dec 2010]
GeneCards Summary for DND1 Gene
DND1 (DND MicroRNA-Mediated Repression Inhibitor 1) is a Protein Coding gene. Diseases associated with DND1 include embryonal testis carcinoma and tongue squamous cell carcinoma. GO annotations related to this gene include nucleic acid binding and AU-rich element binding. An important paralog of this gene is HNRNPR.
UniProtKB/Swiss-Prot for DND1 Gene
RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3 untranslated region (3-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity).