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Aliases for DNASE2B Gene

Aliases for DNASE2B Gene

  • Deoxyribonuclease II Beta 2 3 4
  • DLAD 3 4 6
  • DNase II-Like Acid DNase 3 4
  • DNase2-Like Acid DNase 3 4
  • Endonuclease DLAD 3 4
  • DNase II Beta 3 4
  • Deoxyribonuclease-2-Beta 3
  • Lysosomal DNase II 3
  • EC 3.1.22.1 4

External Ids for DNASE2B Gene

Previous GeneCards Identifiers for DNASE2B Gene

  • GC01P084577
  • GC01P084864
  • GC01P082974

Summaries for DNASE2B Gene

Entrez Gene Summary for DNASE2B Gene

  • The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DNASE2B Gene

DNASE2B (Deoxyribonuclease II Beta) is a Protein Coding gene. Diseases associated with DNASE2B include alcohol dependence. Among its related pathways are Lysosome. GO annotations related to this gene include deoxyribonuclease II activity. An important paralog of this gene is DNASE2.

UniProtKB/Swiss-Prot for DNASE2B Gene

  • Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNASE2B Gene

Genomics for DNASE2B Gene

Regulatory Elements for DNASE2B Gene

Genomic Location for DNASE2B Gene

Start:
84,398,532 bp from pter
End:
84,415,018 bp from pter
Size:
16,487 bases
Orientation:
Plus strand

Genomic View for DNASE2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNASE2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNASE2B Gene

Proteins for DNASE2B Gene

  • Protein details for DNASE2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WZ79-DNS2B_HUMAN
    Recommended name:
    Deoxyribonuclease-2-beta
    Protein Accession:
    Q8WZ79
    Secondary Accessions:
    • Q5VXD0
    • Q5VXD1
    • Q8WZ80
    • Q9NQW3

    Protein attributes for DNASE2B Gene

    Size:
    361 amino acids
    Molecular mass:
    41713 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF76893.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DNASE2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNASE2B Gene

Proteomics data for DNASE2B Gene at MOPED

Post-translational modifications for DNASE2B Gene

  • Glycosylation at Asn81, Asn103, Asn119, and Asn278
  • Modification sites at PhosphoSitePlus

Other Protein References for DNASE2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNASE2B Gene

Domains for DNASE2B Gene

Protein Domains for DNASE2B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DNASE2B Gene

Graphical View of Domain Structure for InterPro Entry

Q8WZ79

UniProtKB/Swiss-Prot:

DNS2B_HUMAN :
  • Q8WZ79
Family:
  • Belongs to the DNase II family.
genes like me logo Genes that share domains with DNASE2B: view

No data available for Gene Families for DNASE2B Gene

Function for DNASE2B Gene

Molecular function for DNASE2B Gene

UniProtKB/Swiss-Prot CatalyticActivity: Endonucleolytic cleavage to nucleoside 3-phosphates and 3-phosphooligonucleotide end-products
UniProtKB/Swiss-Prot Function: Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation.

Enzyme Numbers (IUBMB) for DNASE2B Gene

Gene Ontology (GO) - Molecular Function for DNASE2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004520 endodeoxyribonuclease activity --
GO:0004531 deoxyribonuclease II activity IBA --
genes like me logo Genes that share ontologies with DNASE2B: view

Phenotypes for DNASE2B Gene

genes like me logo Genes that share phenotypes with DNASE2B: view

Animal Models for DNASE2B Gene

MGI Knock Outs for DNASE2B:

Animal Model Products

CRISPR Products

miRNA for DNASE2B Gene

miRTarBase miRNAs that target DNASE2B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNASE2B

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for DNASE2B Gene

Localization for DNASE2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNASE2B Gene

Lysosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNASE2B Gene COMPARTMENTS Subcellular localization image for DNASE2B gene
Compartment Confidence
lysosome 4
vacuole 4
extracellular 2
cytoskeleton 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DNASE2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005622 intracellular IBA --
GO:0005737 cytoplasm --
GO:0005764 lysosome IEA --
genes like me logo Genes that share ontologies with DNASE2B: view

Pathways for DNASE2B Gene

SuperPathways for DNASE2B Gene

Superpath Contained pathways
1 Lysosome
genes like me logo Genes that share pathways with DNASE2B: view

Pathways by source for DNASE2B Gene

1 KEGG pathway for DNASE2B Gene

Interacting Proteins for DNASE2B Gene

Gene Ontology (GO) - Biological Process for DNASE2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006259 DNA metabolic process --
GO:0006309 apoptotic DNA fragmentation IBA --
genes like me logo Genes that share ontologies with DNASE2B: view

Transcripts for DNASE2B Gene

Unigene Clusters for DNASE2B Gene

Deoxyribonuclease II beta:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNASE2B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DNASE2B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNASE2B Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2: -
SP3:

Relevant External Links for DNASE2B Gene

GeneLoc Exon Structure for
DNASE2B
ECgene alternative splicing isoforms for
DNASE2B

Expression for DNASE2B Gene

mRNA expression in normal human tissues for DNASE2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNASE2B Gene

This gene is overexpressed in Minor Salivary Gland (10.3), Lung (4.7), and Muscle - Skeletal (4.6).

SOURCE GeneReport for Unigene cluster for DNASE2B Gene Hs.129142

mRNA Expression by UniProt/SwissProt for DNASE2B Gene

Q8WZ79-DNS2B_HUMAN
Tissue specificity: Highly expressed in the eye lens and in salivary gland. Detected at lower levels in lung, prostate and lymph node. Isoform 2 is lung specific.
genes like me logo Genes that share expressions with DNASE2B: view

In Situ Assay Products

No data available for Protein expression for DNASE2B Gene

Orthologs for DNASE2B Gene

This gene was present in the common ancestor of animals.

Orthologs for DNASE2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNASE2B 35
  • 99.35 (n)
  • 99.72 (a)
DNASE2B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNASE2B 35
  • 88.62 (n)
  • 85.63 (a)
DNASE2B 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNASE2B 35
  • 86.78 (n)
  • 84.84 (a)
DNASE2B 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnase2b 35
  • 76.27 (n)
  • 66.95 (a)
Dnase2b 16
Dnase2b 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNASE2B 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnase2b 35
  • 75.77 (n)
  • 66.48 (a)
chicken
(Gallus gallus)
Aves DNASE2 36
  • 54 (a)
OneToOne
DNASE2B 35
  • 61.86 (n)
  • 56.76 (a)
lizard
(Anolis carolinensis)
Reptilia DNASE2B 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnase2b 35
  • 61.09 (n)
  • 55.32 (a)
zebrafish
(Danio rerio)
Actinopterygii DNASE2B 36
  • 47 (a)
OneToOne
LOC562996 35
  • 55.18 (n)
  • 48.48 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003295 35
  • 42.36 (n)
  • 36.31 (a)
fruit fly
(Drosophila melanogaster)
Insecta DNaseII 35
  • 43.76 (n)
  • 32.82 (a)
DNaseII 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea crn-6 36
  • 26 (a)
ManyToMany
crn-7 36
  • 26 (a)
ManyToMany
nuc-1 35
  • 45.45 (n)
  • 34.48 (a)
nuc-1 36
  • 28 (a)
ManyToMany
Species with no ortholog for DNASE2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNASE2B Gene

ENSEMBL:
Gene Tree for DNASE2B (if available)
TreeFam:
Gene Tree for DNASE2B (if available)

Paralogs for DNASE2B Gene

Paralogs for DNASE2B Gene

genes like me logo Genes that share paralogs with DNASE2B: view

Variants for DNASE2B Gene

Sequence variations from dbSNP and Humsavar for DNASE2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs472601 -- 84,404,721(+) ctaac(C/T)ttaga intron-variant
rs507772 -- 84,406,240(+) ACCAG(A/G)AGCAT intron-variant
rs511339 -- 84,406,822(+) AGACC(A/G)ACTGG intron-variant, upstream-variant-2KB
rs528310 -- 84,403,370(+) atctt(A/T)tatac intron-variant
rs553775 -- 84,403,791(+) tcttt(A/T)tattt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNASE2B Gene

Variant ID Type Subtype PubMed ID
nsv830437 CNV Gain+Loss 17160897
nsv823387 CNV Loss 20364138

Relevant External Links for DNASE2B Gene

HapMap Linkage Disequilibrium report
DNASE2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNASE2B Gene

Disorders for DNASE2B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for DNASE2B Gene including...

Search for DNASE2B Gene in MalaCards »

Relevant External Links for DNASE2B

Genetic Association Database (GAD)
DNASE2B
Human Genome Epidemiology (HuGE) Navigator
DNASE2B
genes like me logo Genes that share disorders with DNASE2B: view

No data available for UniProtKB/Swiss-Prot for DNASE2B Gene

Publications for DNASE2B Gene

  1. Isolation and characterization of the DLAD/Dlad genes, which lie head-to-head with the genes for urate oxidase. (PMID: 11700027) Shiokawa D. … Tanuma S. (Biochem. Biophys. Res. Commun. 2001) 3 4 23
  2. Nuclear cataract caused by a lack of DNA degradation in the mouse eye lens. (PMID: 12944971) Nishimoto S. … Nagata S. (Nature 2003) 3 4 23
  3. The cloning, genomic structure, localization, and expression of human deoxyribonuclease IIbeta. (PMID: 11376952) Krieser R.J. … Eastman A. (Gene 2001) 2 3 4
  4. A family history of deoxyribonuclease II: surprises from Trichinella spiralis and Burkholderia pseudomallei. (PMID: 12594037) MacLea K.S. … Eastman A. (Gene 2003) 2 3
  5. Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy. (PMID: 22095909) Lange C.M. … Bochud P.Y. (Hepatology 2012) 3 48

Products for DNASE2B Gene

Sources for DNASE2B Gene

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