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DNASE2B Gene

protein-coding   GIFtS: 54
GCID: GC01P084864

Deoxyribonuclease II Beta

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Deoxyribonuclease II Beta1 2 3     DNase2-Like Acid DNase2 3
DLAD2 3 5     deoxyribonuclease-2-beta2
Endonuclease DLAD2 3     Lysosomal DNase II2
DNase II Beta2 3     EC 3.1.22.13
DNase II-Like Acid DNase2 3     

External Ids:    HGNC: 288751   Entrez Gene: 585112   Ensembl: ENSG000001379767   OMIM: 6080575   UniProtKB: Q8WZ793   

Export aliases for DNASE2B gene to outside databases

Previous GC identifers: GC01P084577 GC01P082974


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNASE2B Gene:
The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase
II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent
cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is
restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in
opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been
described for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DNASE2B Gene:
DNASE2B (deoxyribonuclease II beta) is a protein-coding gene. GO annotations related to this gene include deoxyribonuclease II activity. An important paralog of this gene is DNASE2.

UniProtKB/Swiss-Prot: DNS2B_HUMAN, Q8WZ79
Function: Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in
the degradation of nuclear DNA during lens cell differentiation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNASE2B gene promoter:
         STAT5B   Sox5   AML1a   Hand1   NRSF form 2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNASE2B promoter sequence
   Search Chromatin IP Primers for DNASE2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNASE2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.3   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p22.3

DNASE2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNASE2B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P084864:  view genomic region     (about GC identifiers)

Start:
84,864,215 bp from pter      End:
84,880,701 bp from pter
Size:
16,487 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DNS2B_HUMAN, Q8WZ79 (See protein sequence)
Recommended Name: Deoxyribonuclease-2-beta precursor  
Size: 361 amino acids; 41713 Da
Sequence caution: Sequence=AAF76893.1; Type=Erroneous initiation;
Secondary accessions: Q5VXD0 Q5VXD1 Q8WZ80 Q9NQW3
Alternative splicing: 2 isoforms:  Q8WZ79-1   Q8WZ79-2   

Explore the universe of human proteins at neXtProt for DNASE2B: NX_Q8WZ79

Explore proteomics data for DNASE2B at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn81, Asn103, Asn119, Asn278
  • Modification sites at PhosphoSitePlus

  • See DNASE2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_067056.2  NP_490649.1  

    ENSEMBL proteins: 
     ENSP00000359699   ENSP00000359696  

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    Novus Biologicals DNASE2B Proteins
    Novus Biologicals DNASE2B Lysate
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for DNASE2B (7 products) 

     
    antibodies-online peptides for DNASE2B

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004947 DNase_II

    Graphical View of Domain Structure for InterPro Entry Q8WZ79

    ProtoNet protein and cluster: Q8WZ79

    1 Blocks protein domain: IPB004947 Deoxyribonuclease II

    UniProtKB/Swiss-Prot: DNS2B_HUMAN, Q8WZ79
    Similarity: Belongs to the DNase II family


    Find genes that share domains with DNASE2B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DNS2B_HUMAN, Q8WZ79
    Function: Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in
    the degradation of nuclear DNA during lens cell differentiation
    Catalytic activity: Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide
    end-products

         Enzyme Number (IUBMB): EC 3.1.22.11

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004520endodeoxyribonuclease activity ----
    GO:0004531deoxyribonuclease II activity IBA--
         
    Find genes that share ontologies with DNASE2B           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DNASE2B:
     Decreased viability with pacli  Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dnase2b):
     homeostasis/metabolism  vision/eye 

    Find genes that share phenotypes with DNASE2B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dnase2btm1Osa for DNASE2B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNASE2B
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    miRNA
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    miRTarBase miRNAs that target DNASE2B:
    hsa-mir-335-5p (MIRT016923)

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    SwitchGear 3'UTR luciferase reporter plasmidDNASE2B 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DNS2B_HUMAN, Q8WZ79: Lysosome (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    lysosome4
    vacuole4
    extracellular2
    cytoskeleton1
    golgi apparatus1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005622intracellular IBA--
    GO:0005737cytoplasm ----
    GO:0005764lysosome IEA--

    Find genes that share ontologies with DNASE2B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DNASE2B About    
    See pathways by source

    SuperPathContained pathways About
    1Lysosome
    Lysosome


    Find genes that share SuperPaths with DNASE2B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for DNASE2B):
        Lysosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DNASE2B
    Interactions:

        Search GeneGlobe Interaction Network for DNASE2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for DNASE2B (Q8WZ793 ENSP000003596994) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBL1P287493I2D: score=1 
    DFFAENSP000003662374STRING: ENSP00000366237
    RGNENSP000002533034STRING: ENSP00000253303
    NME1ENSP000000130344STRING: ENSP00000013034
    NME1-NME2ENSP000003768864STRING: ENSP00000376886
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006259DNA metabolic process ----
    GO:0006309apoptotic DNA fragmentation IBA--

    Find genes that share ontologies with DNASE2B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNASE2B (DNS2B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DNASE2B gene (2 alternative transcripts): 
    NM_021233.2  NM_058248.1  

    Unigene Cluster for DNASE2B:

    Deoxyribonuclease II beta
    Hs.129142  [show with all ESTs]
    Unigene Representative Sequence: NM_021233
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370665(uc001djt.1) ENST00000370662(uc001dju.1 uc009wch.1)

    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat DNASE2B

    Additional mRNA sequence: 

    AF274571.1 AF333389.1 BC065182.1 BC080621.1 BC126136.1 BC126138.1 

    3 DOTS entries:

    DT.40127696  DT.95364740  DT.91933341 

    Selected AceView cDNA sequences (see all 34):

    CD365107 CD635711 CD635717 AF333389 NM_058248 CD635715 CD635709 CD635713 
    CD635695 AA988125 BC065182 NM_021233 AI820599 BG761484 BX280577 AW295184 
    BQ681950 AI791998 BC080621 AF274571 CD365871 CD366106 AI802154 AI694455 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DNASE2B    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
    SP1:              -                       -                           
    SP2:                                      -                           
    SP3:                                                                  


    ECgene alternative splicing isoforms for DNASE2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNASE2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DNASE2B Expression
    About this image


    DNASE2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
     
     Lung (Respiratory System)
    DNASE2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNASE2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.129142

    UniProtKB/Swiss-Prot: DNS2B_HUMAN, Q8WZ79
    Tissue specificity: Highly expressed in the eye lens and in salivary gland. Detected at lower levels in lung,
    prostate and lymph node. Isoform 2 is lung specific

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DNASE2B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnase2b1 , 5 deoxyribonuclease II beta1, 5 76.27(n)1
    66.95(a)1
      3 (72.00 cM)5
    566291  NM_019957.41  NP_064341.31 
     1465809855 
    chicken
    (Gallus gallus)
    Aves DNASE2B1 deoxyribonuclease II beta 61.86(n)
    56.76(a)
      424540  NM_001037838.1  NP_001032927.1 
    lizard
    (Anolis carolinensis)
    Reptilia DNASE2B6
    deoxyribonuclease II beta
    52(a)
    1 ↔ 1
    GL343194.1(9509532-9520906)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dnase2b1 deoxyribonuclease II beta 61.09(n)
    55.32(a)
      496759  NM_001011305.1  NP_001011305.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5629961 deoxyribonuclease-2-beta-like 55.18(n)
    48.48(a)
      562996  XM_686359.5  XP_691451.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta DNaseII1 Deoxyribonuclease II 43.76(n)
    32.82(a)
      48228  NM_142415.3  NP_650672.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nuc-11 nuc-1 45.45(n)
    34.48(a)
      181174  NM_077203.5  NP_509604.1 


    ENSEMBL Gene Tree for DNASE2B (if available)
    TreeFam Gene Tree for DNASE2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNASE2B gene
    DNASE22  

    Find genes that share paralogs with DNASE2B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNASE2B (see all 389)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1823137091,2
    --84865778(+) CAGGCA/GTGGTG 1 -- int10--------
    rs1138639731,2
    C--84865789(+) GCTCAC/TGCCTG 1 -- int10--------
    rs1857313801,2
    --84865794(+) CGCCTA/GTAAGC 1 -- int10--------
    rs1898127991,2
    C--84865958(+) AGGCAA/GGAGAA 1 -- int10--------
    rs1486424031,2
    --84866004(+) CAAGAC/TCGTGC 1 -- int10--------
    rs1420470331,2
    C--84866005(+) AAGATC/TGTGCC 1 -- int10--------
    rs12463841,2
    C,F,H--84866116(+) TTCTGT/AGACTG 1 -- int116Minor allele frequency- A:0.02NS EA NA WA CSA 671
    rs1393906301,2
    C--84866196(+) AATACA/GGAGTT 1 -- int10--------
    rs1445536141,2
    C--84866337(+) TAGCTC/TTCAAC 1 -- int10--------
    rs6470651,2
    C,F,A,H--84866354(+) GCCACG/AGCACA 1 -- int110Minor allele frequency- A:0.32NA WA CSA EA 372

    HapMap Linkage Disequilibrium report for DNASE2B (84864215 - 84880701 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DNASE2B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv823387CNV Loss20364138
    nsv830437CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNASE2B
    DNA2.0 Custom Variant and Variant Library Synthesis for DNASE2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608057    OMIM disorders: --


    Find genes that share disorders with DNASE2B           About GenesLikeMe

    Genetic Association Database (GAD): DNASE2B
    Human Genome Epidemiology (HuGE) Navigator: DNASE2B (2 documents)

    Export disorders for DNASE2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNASE2B gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with DNASE2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The cloning, genomic structure, localization, and expression of human deoxyribonuclease IIbeta. (PubMed id 11376952)1, 2, 3 Krieser R.J.... Eastman A. (Gene 2001)
    2. Isolation and characterization of the DLAD/Dlad genes, which lie head-to-head with the genes for urate oxidase. (PubMed id 11700027)1, 2, 9 Shiokawa D. and Tanuma S. (Biochem. Biophys. Res. Commun. 2001)
    3. Nuclear cataract caused by a lack of DNA degradation in the mouse eye lens. (PubMed id 12944971)1, 2, 9 Nishimoto S....Nagata S. (Nature 2003)
    4. Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy. (PubMed id 22095909)1, 4 Lange C.M....Bochud P.Y. (Hepatology 2012)
    5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    6. A family history of deoxyribonuclease II: surprises from Trichinella spiralis and Burkholderia pseudomallei. (PubMed id 12594037)1, 3 MacLea K.S.... Eastman A. (Gene 2003)
    7. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
    8. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
    9. HSF4 regulates DLAD expression and promotes lens de-nucleation. (PubMed id 23507146)1 Cui X....Liu M. (Biochim. Biophys. Acta 2013)
    10. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 58511 HGNC: 28875 AceView: DLAD Ensembl:ENSG00000137976 euGenes: HUgn58511
    ECgene: DNASE2B Kegg: 58511 H-InvDB: DNASE2B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DNASE2B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNASE2B gene:
    Search GeneIP for patents involving DNASE2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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