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Aliases for DNASE2 Gene

Aliases for DNASE2 Gene

  • Deoxyribonuclease II, Lysosomal 2 3
  • Deoxyribonuclease II Alpha 3 4
  • Lysosomal DNase II 3 4
  • DNase II Alpha 3 4
  • EC 3.1.22.1 4 63
  • Acid DNase 3 4
  • R31240_2 3 4
  • DNASE2A 3 4
  • DNL2 3 4
  • DNase II, Lysosomal 3
  • DNL 3

External Ids for DNASE2 Gene

Previous HGNC Symbols for DNASE2 Gene

  • DNL
  • DNL2

Previous GeneCards Identifiers for DNASE2 Gene

  • GC19M013117
  • GC19M013208
  • GC19M012831
  • GC19M012847
  • GC19M012986
  • GC19M012557

Summaries for DNASE2 Gene

Entrez Gene Summary for DNASE2 Gene

  • This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. [provided by RefSeq, Jul 2008]

GeneCards Summary for DNASE2 Gene

DNASE2 (Deoxyribonuclease II, Lysosomal) is a Protein Coding gene. Diseases associated with DNASE2 include nuclear cataract. Among its related pathways are Lysosome and Vesicle-mediated transport. GO annotations related to this gene include endodeoxyribonuclease activity and deoxyribonuclease II activity. An important paralog of this gene is DNASE2B.

UniProtKB/Swiss-Prot for DNASE2 Gene

  • Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNASE2 Gene

Genomics for DNASE2 Gene

Regulatory Elements for DNASE2 Gene

Transcription factor binding sites by QIAGEN in the DNASE2 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DNASE2 Gene

Chromosome:
19
Start:
12,875,211 bp from pter
End:
12,881,521 bp from pter
Size:
6,311 bases
Orientation:
Minus strand

Genomic View for DNASE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNASE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNASE2 Gene

Proteins for DNASE2 Gene

  • Protein details for DNASE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00115-DNS2A_HUMAN
    Recommended name:
    Deoxyribonuclease-2-alpha
    Protein Accession:
    O00115
    Secondary Accessions:
    • B2RD06
    • B7Z4K6
    • O43910

    Protein attributes for DNASE2 Gene

    Size:
    360 amino acids
    Molecular mass:
    39581 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Not required for the generation of the characteristic DNA fragmentation observed in apoptotic cells, but for the degradation of DNA from dying cells.

    Alternative splice isoforms for DNASE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNASE2 Gene

Proteomics data for DNASE2 Gene at MOPED

Selected DME Specific Peptides for DNASE2 Gene

Post-translational modifications for DNASE2 Gene

  • Glycosylated. Mutations that eliminate N-glycosylation sites reduce activity, but enzymatic deglycosylation has no effect.
  • Glycosylation at Asn 86, Asn 212, Asn 266, and Asn 290
  • Modification sites at PhosphoSitePlus

Other Protein References for DNASE2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for DNASE2

Domains & Families for DNASE2 Gene

Protein Domains for DNASE2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O00115

UniProtKB/Swiss-Prot:

DNS2A_HUMAN :
  • Belongs to the DNase II family.
Family:
  • Belongs to the DNase II family.
genes like me logo Genes that share domains with DNASE2: view

No data available for Gene Families for DNASE2 Gene

Function for DNASE2 Gene

Molecular function for DNASE2 Gene

GENATLAS Biochemistry:
DNase II,lysosomal,acidic,38/40kDa,ubiquitously expressed
UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage to nucleoside 3-phosphates and 3-phosphooligonucleotide end-products
UniProtKB/Swiss-Prot Function:
Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells

Enzyme Numbers (IUBMB) for DNASE2 Gene

Gene Ontology (GO) - Molecular Function for DNASE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 9714827
GO:0004520 endodeoxyribonuclease activity --
GO:0004531 deoxyribonuclease II activity IEA --
genes like me logo Genes that share ontologies with DNASE2: view
genes like me logo Genes that share phenotypes with DNASE2: view

Animal Models for DNASE2 Gene

MGI Knock Outs for DNASE2:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNASE2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for DNASE2 Gene

Localization for DNASE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNASE2 Gene

Lysosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNASE2 Gene COMPARTMENTS Subcellular localization image for DNASE2 gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
nucleus 1

Gene Ontology (GO) - Cellular Components for DNASE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DNASE2: view

Pathways & Interactions for DNASE2 Gene

genes like me logo Genes that share pathways with DNASE2: view

Pathways by source for DNASE2 Gene

Gene Ontology (GO) - Biological Process for DNASE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000737 DNA catabolic process, endonucleolytic --
GO:0006259 DNA metabolic process TAS 9714827
GO:0006308 DNA catabolic process --
GO:0006309 apoptotic DNA fragmentation IBA --
GO:0030218 erythrocyte differentiation IEA --
genes like me logo Genes that share ontologies with DNASE2: view

No data available for SIGNOR curated interactions for DNASE2 Gene

Drugs & Compounds for DNASE2 Gene

(2) Drugs for DNASE2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Menadione Approved Nutra 183
Vitamin C Approved Nutra 398,398
genes like me logo Genes that share compounds with DNASE2: view

Transcripts for DNASE2 Gene

Unigene Clusters for DNASE2 Gene

Deoxyribonuclease II, lysosomal:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNASE2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNASE2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c
SP1: -
SP2: - - -
SP3:
SP4:

Relevant External Links for DNASE2 Gene

GeneLoc Exon Structure for
DNASE2
ECgene alternative splicing isoforms for
DNASE2

Expression for DNASE2 Gene

mRNA expression in normal human tissues for DNASE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNASE2 Gene

This gene is overexpressed in Amniocyte (15.3) and Vitreous humor (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNASE2 Gene



SOURCE GeneReport for Unigene cluster for DNASE2 Gene Hs.118243

genes like me logo Genes that share expression patterns with DNASE2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DNASE2 Gene

Orthologs for DNASE2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNASE2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNASE2 35
  • 79.3 (n)
  • 73.47 (a)
DNASE2 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNASE2 35
  • 80.9 (n)
  • 75.22 (a)
DNASE2 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnase2a 35
  • 78.81 (n)
  • 72.89 (a)
Dnase2a 16
Dnase2a 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DNASE2 35
  • 99.17 (n)
  • 98.89 (a)
DNASE2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnase2 35
  • 77.91 (n)
  • 73.26 (a)
oppossum
(Monodelphis domestica)
Mammalia DNASE2 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNASE2 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnase2 35
  • 54.57 (n)
  • 48.97 (a)
zebrafish
(Danio rerio)
Actinopterygii dnase2 35
  • 52.61 (n)
  • 43.3 (a)
dnase2 36
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta DNaseII 37
  • 32 (a)
DNaseII 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F09G8.2 37
  • 34 (a)
K04H4.6a 37
  • 31 (a)
K04H4.6b 37
  • 31 (a)
crn-7 35
  • 43.03 (n)
  • 36.06 (a)
crn-6 36
  • 27 (a)
ManyToMany
crn-7 36
  • 30 (a)
ManyToMany
nuc-1 36
  • 30 (a)
ManyToMany
Species with no ortholog for DNASE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNASE2 Gene

ENSEMBL:
Gene Tree for DNASE2 (if available)
TreeFam:
Gene Tree for DNASE2 (if available)

Paralogs for DNASE2 Gene

Paralogs for DNASE2 Gene

genes like me logo Genes that share paralogs with DNASE2: view

Variants for DNASE2 Gene

Sequence variations from dbSNP and Humsavar for DNASE2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1061192 - 12,876,132(-) GAATC(G/T)GAACC reference, missense
rs1210383 -- 12,882,082(-) cgcag(G/T)ggctc upstream-variant-2KB
rs1210384 -- 12,882,063(-) aatct(G/T)ggcac upstream-variant-2KB
rs1802335 -- 12,876,061(-) CCTTC(C/T)AGCCG reference, stop-gained
rs1802336 -- 12,875,706(-) AAAGG(G/T)GGGGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DNASE2 Gene

Variant ID Type Subtype PubMed ID
dgv3733n71 CNV Loss 21882294
nsv911082 CNV Loss 21882294
nsv911083 CNV Loss 21882294
nsv911084 CNV Loss 21882294
nsv833754 CNV Loss 17160897

Variation tolerance for DNASE2 Gene

Residual Variation Intolerance Score: 47.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNASE2 Gene

HapMap Linkage Disequilibrium report
DNASE2
Human Gene Mutation Database (HGMD)
DNASE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNASE2 Gene

Disorders for DNASE2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DNASE2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
nuclear cataract
- elite association

Relevant External Links for DNASE2

Genetic Association Database (GAD)
DNASE2
Human Genome Epidemiology (HuGE) Navigator
DNASE2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNASE2
genes like me logo Genes that share disorders with DNASE2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNASE2 Gene

Publications for DNASE2 Gene

  1. Regulation of poly(ADP-ribose) polymerase-1 functions by leukocyte elastase inhibitor/LEI-derived DNase II during caspase-independent apoptosis. (PMID: 18951996) LeprA-tre C. … Torriglia A. (Int. J. Biochem. Cell Biol. 2009) 23 67
  2. Altered deoxyribonuclease activity in cancer cells and its role in non toxic adjuvant cancer therapy with mixed vitamins C and K3. (PMID: 19035302) Taper H.S. (Anticancer Res. 2008) 23 67
  3. Acid DNases and their interest among apoptotic endonucleases. (PMID: 16989934) Counis M.F. … Torriglia A. (Biochimie 2006) 23 67
  4. The association of vitamins C and K3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use as coadjuvants in anticancer therapy. (PMID: 12767595) Verrax J. … Buc Calderon P. (Eur J Med Chem 2003) 23 67
  5. Structural requirements of human DNase II alpha for formation of the active enzyme: the role of the signal peptide, N-glycosylation, and disulphide bridging. (PMID: 12558498) MacLea K.S. … Eastman A. (Biochem. J. 2003) 23 67

Products for DNASE2 Gene

Sources for DNASE2 Gene

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