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DNASE2 Gene

protein-coding   GIFtS: 63
GCID: GC19M012986

Deoxyribonuclease II, Lysosomal


(Previous symbols: DNL, DNL2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Deoxyribonuclease II, Lysosomal1 2     DNASE2A2 3
DNL21 2 3     R31240_22 3
DNL1 2 5     DNase II Alpha2 3
Acid DNase2 3     EC 3.1.22.13 8
Deoxyribonuclease II Alpha2 3     deoxyribonuclease-2-alpha2
Lysosomal DNase II2 3     DNase II, Lysosomal2

External Ids:    HGNC: 29601   Entrez Gene: 17772   Ensembl: ENSG000001056127   OMIM: 1263505   UniProtKB: O001153   

Export aliases for DNASE2 gene to outside databases

Previous GC identifers: GC19M013117 GC19M013208 GC19M012831 GC19M012847 GC19M012557


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNASE2 Gene:
This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic
conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have
been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the
promoter region. The DNASE2*H allele is represented in this record. (provided by RefSeq, Jul 2008)

GeneCards Summary for DNASE2 Gene:
DNASE2 (deoxyribonuclease II, lysosomal) is a protein-coding gene. Diseases associated with DNASE2 include acne, and cataract. GO annotations related to this gene include deoxyribonuclease II activity. An important paralog of this gene is DNASE2B.

UniProtKB/Swiss-Prot: DNS2A_HUMAN, O00115
Function: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in
the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development
and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor
cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNASE2 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNASE2 promoter sequence
   Search Chromatin IP Primers for DNASE2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNASE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

DNASE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNASE2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M012986:  view genomic region     (about GC identifiers)

Start:
12,986,025 bp from pter      End:
12,992,335 bp from pter
Size:
6,311 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DNS2A_HUMAN, O00115 (See protein sequence)
Recommended Name: Deoxyribonuclease-2-alpha precursor  
Size: 360 amino acids; 39581 Da
Miscellaneous: Not required for the generation of the characteristic DNA fragmentation observed in apoptotic
cells, but for the degradation of DNA from dying cells (By similarity)
Secondary accessions: B2RD06 O43910

Explore the universe of human proteins at neXtProt for DNASE2: NX_O00115

Explore proteomics data for DNASE2 at MOPED

Post-translational modifications: 

  • Glycosylated. Mutations that eliminate N-glycosylation sites reduce activity, but enzymatic deglycosylation has no
    effect1
  • Glycosylation2 at Asn86, Asn212, Asn266, Asn290
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DNASE2 (O00115) (see all 5)
     DHSKWCV  QLTYTYP  CVGDMNRN  VDWFVVYKLP 


    See DNASE2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001366.1  
    ENSEMBL proteins: 
     ENSP00000222219   ENSP00000466912   ENSP00000445988  
    Reactome Protein details: O00115

    DNASE2 Human Recombinant Protein Products:

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    Novus Biologicals DNASE2 Proteins
    Novus Biologicals DNASE2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    DNASE2 Antibody Products:

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    DNASE2 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004947 DNase_II

    Graphical View of Domain Structure for InterPro Entry O00115

    ProtoNet protein and cluster: O00115

    1 Blocks protein domain: IPB004947 Deoxyribonuclease II

    UniProtKB/Swiss-Prot: DNS2A_HUMAN, O00115
    Similarity: Belongs to the DNase II family


    DNASE2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DNS2A_HUMAN, O00115
    Function: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in
    the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development
    and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor
    cells
    Catalytic activity: Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide
    end-products

         Genatlas biochemistry entry for DNASE2:
    DNase II,lysosomal,acidic,38/40kDa,ubiquitously expressed

         Enzyme Number (IUBMB): EC 3.1.22.11 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS9714827
    GO:0004520endodeoxyribonuclease activity ----
    GO:0004531deoxyribonuclease II activity IBA--
         
    DNASE2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DNASE2:
     Decreased Salmonella enterica   Increased G1 DNA content 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dnase2a):
     cellular  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  muscle  skeleton 

    DNASE2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DNASE2: Dnase2atm1Osa Dnase2atm1Aea

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNASE2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DNASE2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DNASE2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DNASE2

    miRNA
    Products:
        
    miRTarBase miRNAs that target DNASE2:
    hsa-mir-320b (MIRT036213), hsa-mir-186-5p (MIRT045041)

    Block miRNA regulation of human, mouse, rat DNASE2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate DNASE2:
    hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidDNASE2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DNASE2
    Predesigned siRNA for gene silencing in human, mouse, rat DNASE2

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DNASE2 (NM_001375)
    Sino Biological Human cDNA Clone for DNASE2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNASE2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNASE2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNASE2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DNS2A_HUMAN, O00115: Lysosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    lysosome5
    vacuole5
    extracellular3
    plasma membrane2
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IBA--
    GO:0005764lysosome IEA--

    DNASE2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DNASE2 About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    Lysosome Vesicle Biogenesis0.41
    trans-Golgi Network Vesicle Budding0.89
    Membrane Trafficking0.32
    2Lysosome
    Lysosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for DNASE2
        Lysosome Vesicle Biogenesis


    1 Kegg Pathway  (Kegg details for DNASE2):
        Lysosome


    DNASE2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DNASE2
    Interactions:

        Search GeneGlobe Interaction Network for DNASE2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for DNASE2 (O001151, 3 ENSP000002222194) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RUVBL2Q9Y2301, 3, ENSP000002214134EBI-1051412,EBI-352939 I2D: score=2 STRING: ENSP00000221413
    RUVBL1Q9Y2651, 3, ENSP000003182974EBI-1051412,EBI-353675 I2D: score=2 STRING: ENSP00000318297
    BEST2Q8NFU13I2D: score=1 
    DFFAENSP000003662374STRING: ENSP00000366237
    RGNENSP000002533034STRING: ENSP00000253303
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006259DNA metabolic process TAS9714827
    GO:0006308DNA catabolic process ----
    GO:0006309apoptotic DNA fragmentation IBA--
    GO:0006915apoptotic process ----
    GO:0030218erythrocyte differentiation IEA--

    DNASE2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNASE2 (DNS2A)

    2 Novoseek inferred chemical compound relationships for DNASE2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    menadione 68.3 3 19035302 (1), 12767595 (1), 11118483 (1)
    ascorbic acid 35.1 4 19035302 (1), 12767595 (1), 11118483 (1)



    DNASE2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DNASE2 gene: 
    NM_001375.2  

    Unigene Cluster for DNASE2:

    Deoxyribonuclease II, lysosomal
    Hs.118243  [show with all ESTs]
    Unigene Representative Sequence: NM_001375
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222219(uc002mvn.1 uc010xmr.1) ENST00000588777 ENST00000592506
    ENST00000586547 ENST00000538460
    miRNA
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    Block miRNA regulation of human, mouse, rat DNASE2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate DNASE2:
    hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidDNASE2 3' UTR sequence
    Inhib. RNA
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    OriGene qPCR primer pairs and template standards for DNASE2
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      QuantiTect SYBR Green Assays in human, mouse, rat DNASE2
      QuantiFast Probe-based Assays in human, mouse, rat DNASE2

    Additional mRNA sequence: 

    AB004574.1 AF045937.1 AF047016.1 AF060222.1 AK075449.1 AK297493.1 AK311145.1 AK315358.1 
    BC010419.2 BC065209.1 BT007047.1 FJ752529.1 

    9 DOTS entries:

    DT.315414  DT.100795729  DT.100771120  DT.100035761  DT.100795732  DT.101980499  DT.121409875  DT.95171534 
    DT.121409873 

    Selected AceView cDNA sequences (see all 198):

    BC065209 CF146152 BQ064813 BU543891 AA995641 CR617284 BM853782 AF045937 
    BM465274 CA447617 BQ064287 BQ678764 BX283158 BP341524 BP342421 BM761074 
    NM_001375 AF060222 BM995228 CD516609 BQ882916 CD108536 BG283546 CR608424 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DNASE2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:                    -                                             
    SP2:                    -     -     -                                 
    SP3:                                                                  
    SP4:                                                                  


    ECgene alternative splicing isoforms for DNASE2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNASE2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DNASE2 Expression
    About this image


    DNASE2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)
             Perivenous Hepatocytes Liver Lobule
     
     Prostate (Endocrine System)
    DNASE2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNASE2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.118243
        Custom PCR Arrays for DNASE2
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNASE2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DNASE2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnase2a1 , 5 deoxyribonuclease II alpha1, 5 78.81(n)1
    72.89(a)1
      8 (41.31 cM)5
    134231  NM_010062.31  NP_034192.11 
     849085605 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dnase21 deoxyribonuclease II, lysosomal 54.57(n)
    48.97(a)
      733868  NM_001045608.1  NP_001039073.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dnase21 deoxyribonuclease II, lysosomal 52.61(n)
    43.3(a)
      100000399  NM_001114738.1  NP_001108210.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta DNaseII3 deoxyribonuclease II 32(a)   3 90D6   --
    worm
    (Caenorhabditis elegans)
    Secernentea F09G8.23
    crn-71
    crn-71 34(a)
    (best of 3)3
    43.03(n)1
    36.06(a)1
      III(8340356-8341736)3
    1761661  NM_066416.31  NP_498817.11 


    ENSEMBL Gene Tree for DNASE2 (if available)
    TreeFam Gene Tree for DNASE2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNASE2 gene
    DNASE2B2  

    DNASE2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNASE2 (see all 169)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1834255481,2
    --12986281(+) GCTCAA/TGACAA 1 -- ut310--------
    rs1414959841,2
    --12986514(+) TCCCCA/CGCCCC 1 -- ut310--------
    rs116701071,2
    H--12986522(+) CCCCCC/Tttttt 1 -- ut31 trp30--------
    rs1134102701,2
    C--12986522(+) CCCCCT/-TTTTT 1 -- ut311Minor allele frequency- -:0.50CSA 2
    rs1862721741,2
    --12986555(+) GTGACC/TCAGGT 1 -- ut310--------
    rs1471169681,2
    --12986565(+) TTGGCA/GTAATC 1 -- ut310--------
    rs795952811,2
    C,F--12986697(+) TCACTA/GTGTAG 1 -- ut311Minor allele frequency- G:0.01EA 120
    rs1920251671,2
    --12986730(+) GAGTTC/GAAGTG 1 -- ut310--------
    rs2001245891,2
    C--12986777(+) CATACG/ATGAGC 1 -- ut311Minor allele frequency- A:0.00EU 593
    rs1385349911,2
    C,F--12986892(+) AGAGGG/TCTGGC 2 D A mis11Minor allele frequency- T:0.00NA 4500

    HapMap Linkage Disequilibrium report for DNASE2 (12986025 - 12992335 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DNASE2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911082CNV Loss21882294
    nsv911084CNV Loss21882294
    nsv833754CNV Loss17160897
    nsv911083CNV Loss21882294
    dgv3733n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): DNASE2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNASE2
    DNA2.0 Custom Variant and Variant Library Synthesis for DNASE2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 126350    OMIM disorders: --

    9 diseases for DNASE2:    
    About MalaCards
    acne    cataract    systemic lupus erythematosus    lupus erythematosus
    diabetes mellitus    malaria    rheumatoid arthritis    arthritis
    prostatitis


    DNASE2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DNASE2
    Human Genome Epidemiology (HuGE) Navigator: DNASE2 (3 documents)

    Export disorders for DNASE2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNASE2 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with DNASE2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural requirements of human DNase II alpha for formation of the active enzyme: the role of the signal peptide, N-glycosylation, and disulphide bridging. (PubMed id 12558498)1, 2, 9 MacLea K.S.... Eastman A. (Biochem. J. 2003)
    2. Molecular cloning of the cDNA encoding human deoxyribonuclease II. (PubMed id 9446563)1, 2, 9 Yasuda T.... Kishi K. (J. Biol. Chem. 1998)
    3. Homozygosity for DNASE2 single nucleotide polymorphisms in the 5'-regulatory region is associated with rheumatoid arthritis. (PubMed id 18812394)1, 4 Rossol M....Wagner U. (Ann. Rheum. Dis. 2009)
    4. DNase II polymorphisms associated with risk of renal disorder among systemic lupus erythematosus patients. (PubMed id 15723160)1, 4 Shin H.D....Bae S.C. (J. Hum. Genet. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    7. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (Nat. Biotechnol. 2003)
    8. A family history of deoxyribonuclease II: surprises from Trichinella spiralis and Burkholderia pseudomallei. (PubMed id 12594037)1, 2 MacLea K.S.... Eastman A. (Gene 2003)
    9. Revised structure of the active form of human deoxyribonuclease IIalpha. (PubMed id 11906178)1, 2 MacLea K.S.... Eastman A. (Biochem. Biophys. Res. Commun. 2002)
    10. Molecular cloning and characterization of human and murine DNase II. (PubMed id 9714827)1, 2 Baker K.P.... Spencer S.A. (Gene 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1777 HGNC: 2960 AceView: DNASE2 Ensembl:ENSG00000105612 euGenes: HUgn1777
    ECgene: DNASE2 Kegg: 1777 H-InvDB: DNASE2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DNASE2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNASE2 gene:
    Search GeneIP for patents involving DNASE2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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