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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DNASE1L3 Gene

protein-coding   GIFtS: 54
GCID: GC03M058153

deoxyribonuclease I-like 3
 Explore 7 diseases affiliated with
DNASE1L3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DNASE1L3    

Aliases
for DNASE1L3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Deoxyribonuclease I-Like 31 2 3     Liver And Spleen DNase2 3
DNAS1L31 2 3     SLEB162
LSD1 2 3     Deoxyribonuclease Gamma2
DHP22 3     Deoxyribonuclease I-Like III2
LS-DNase2 3     DNase I Homolog Protein 22
DNase Gamma2 3     EC 3.1.21.-3
DNase I Homolog Protein DHP22 3     EC 3.1.21.18
DNase I-Like 32 3     

External Ids:    HGNC: 29591   Entrez Gene: 17762   Ensembl: ENSG000001636877   OMIM: 6022445   UniProtKB: Q136093   

Export aliases for DNASE1L3 gene to outside databases

Previous GC identifers: GC03P057199 GC03M057547 GC03M058033 GC03M058135


Summaries
for DNASE1L3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DNASE1L3:
This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by
actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus
erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this
gene. (provided by RefSeq, Feb 2012)

UniProtKB/Swiss-Prot: DNSL3_HUMAN, Q13609
Function: Has DNA hydrolytic activity. Does not bind to actin. Cleaves chromatin DNA to nucleosomal units

Gene Wiki entry for DNASE1L3


Genomic Views
for DNASE1L3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DNASE1L3 gene promoter:
         c-Fos   AP-1   AML1a   JunB   Fra-1   FosB   JunD   FOXO4   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): DNASE1L3 promoter sequence
   Search SABiosciences Chromatin IP Primers for DNASE1L3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNASE1L3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.3   Ensembl cytogenetic band:  3p14.3   HGNC cytogenetic band: 3p14.3

DNASE1L3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNASE1L3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M058153:  view genomic region     (about GC identifiers)

Start:
 58,177,984 bp from pter      End:
 58,200,424 bp from pter
Size:
 22,441 bases      Orientation:
 minus strand

Proteins
for DNASE1L3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DNSL3_HUMAN, Q13609 (See protein sequence)
Recommended Name: Deoxyribonuclease gamma precursor  
Size: 305 amino acids; 35504 Da
Cofactor: Calcium
Cofactor: Magnesium
Subcellular location: Nucleus. Note=May first pass through the ER membrane before being imported in the nucleus
Secondary accessions: B2R8B1 O75803

Explore the universe of human proteins at neXtProt for DNASE1L3: NX_Q13609

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13609

    • 4 DME Specific Peptides for DNASE1L3 (Q13609)
     CAYDRIV  SDHFPVE  FSREPFVV  GDFNAGCSYV 

    DNASE1L3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243489.1  NP_004935.1  

    ENSEMBL proteins: 
     ENSP00000419052   ENSP00000417047   ENSP00000417976   ENSP00000378053   ENSP00000418113  
     ENSP00000418509   ENSP00000316193  

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    OriGene Protein Over-expression Lysate: DNASE1L3
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    Novus Biologicals DNASE1L3 Proteins
    Novus Biologicals DNASE1L3 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DNASE1L3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    DNASE1L3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DNASE1L3

    Protein Domains /
    Families
    for DNASE1L3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DNASE1L3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR016202 DNase_I-like
     IPR005135 Endo/exonuclease/phosphatase
     IPR008185 DNase_I_euk
     IPR018057 Deoxyribonuclease-1_AS

    Graphical View of Domain Structure for InterPro Entry Q13609

    ProtoNet protein and cluster: Q13609

    1 Blocks protein family: IPB008185 Deoxyribonuclease I

    UniProtKB/Swiss-Prot: DNSL3_HUMAN, Q13609
    Similarity: Belongs to the DNase I family


    Function
    for DNASE1L3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DNSL3_HUMAN, Q13609
    Function: Has DNA hydrolytic activity. Does not bind to actin. Cleaves chromatin DNA to nucleosomal units
    Enzyme regulation: Inhibited by zinc
    Biophysicochemical properties: pH dependence: Optimum pH is about 7.2;

         Genatlas biochemistry entry for DNASE1L3:
    DNase I-like endonuclease,33kDa,expressed in liver and spleen,actin-resistant,specific to macrophage populations

    Enzyme Numbers (IUBMB): EC 3.1.21.-1 EC 3.1.21.12

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for DNASE1L3

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004519endonuclease activity ----
    GO:0004520endodeoxyribonuclease activity ----
    GO:0004536deoxyribonuclease activity TAS9070308
    GO:0005509calcium ion binding TAS9205125


    DNASE1L3 for ontologies           About GeneDecksing



    Pathways & Interactions
    for DNASE1L3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNASE1L3

    1 Interacting protein for DNASE1L3 (Q136093) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADAMTSL4Q6UY143I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006259DNA metabolic process TAS9070308
    GO:0006308DNA catabolic process ----
    GO:0006309apoptotic DNA fragmentation IEA--
    GO:0006915apoptotic process ----


    DNASE1L3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DNASE1L3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DNASE1L3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DNASE1L3

    2 HMDB Compounds for DNASE1L3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--
    2 Novoseek chemical compound relationships for DNASE1L3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aurintricarboxylic acid 76.6 1 14556310 (1)
    paraffin 24.2 3 15118903 (1), 12802584 (1)

    Search CenterWatch for drugs/clinical trials and news about DNASE1L3 / DNSL3 

    Transcripts
    for DNASE1L3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DNASE1L3 gene (2 alternative transcripts): 
    NM_001256560.1  NM_004944.3  

    Unigene Cluster for DNASE1L3:

    Deoxyribonuclease I-like 3
    Hs.476453  [show with all ESTs]
    Unigene Representative Sequence: AK301263
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486455 ENST00000483681(uc003djo.1 uc011bfd.1 uc003djq.1)
    ENST00000477209 ENST00000394549 ENST00000461914 ENST00000460422 ENST00000463694
    ENST00000318316(uc003djp.1)

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNASE1L3 (see all 7)
    OriGene shRNA RFP: DNASE1L3
    OriGene siRNA: DNASE1L3
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNASE1L3
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    Additional cDNA sequence: 

    AF047354.1 AK301263.1 AK313303.1 BC015831.1 U56814.1 

    9 DOTS entries:

    DT.91680725  DT.112581  DT.95166001  DT.99968742  DT.101977647  DT.106261  DT.75131550  DT.95166002 
    DT.99933446 

    24/86 AceView cDNA sequences (see all 86):

    AI767476 AW827162 BE048177 CK300923 U56814 CR602169 BQ710632 CR607614 
    CB161995 CA449306 CB164149 AW025144 BI521582 AW275495 AL572037 AI248904 
    BI460950 BF434855 BG566893 BI833952 BX476354 BP340512 AI434430 BF594719 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DNASE1L3    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
    SP1:        -                                                                                 
    SP2:                                                                                          
    SP3:                                                                                -         
    SP4:                          -     -                                                         


    ECgene alternative splicing isoforms for DNASE1L3

    Expression
    for DNASE1L3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DNASE1L3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGTGACTTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DNASE1L3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobulePeriportal HepatocytesLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium

    See DNASE1L3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DNASE1L3

    SOURCE GeneReport for Unigene cluster: Hs.476453

    UniProtKB/Swiss-Prot: DNSL3_HUMAN, Q13609
    Tissue specificity: Liver and spleen

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    In Situ
    Assay Products:     
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    Orthologs
    for DNASE1L3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for DNASE1L3 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dnase1l31 , 5 deoxyribonuclease 1-like 31, 5 83.77(n)1
    81.58(a)1    		   14 (4.67 cM)5
    134211  NM_007870.31  NP_031896.31 
     79645335 
    chicken
    (Gallus gallus)    		 Aves DNASE1L31 deoxyribonuclease I-like 3 66.55(n)
    58.59(a)    		   416008  NM_001034815.1  NP_001029987.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DNASE1L36
    		 --
    		 57(a)
    		 1 ↔ 1
    		 2(163718543-163736038)
    African clawed frog
    (Xenopus laevis)    		 Amphibia drng-A-prov2 deoxyribonuclease gamma 77.12(n)    AF059612.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC056304.12   -- 72.83(n)    BC056304.1 


    ENSEMBL Gene Tree for DNASE1L3 (if available)
    TreeFam Gene Tree for DNASE1L3 (if available) 

    Paralogs
    for DNASE1L3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DNASE1L3 gene
    DNASE1L22  DNASE12  DNASE1L12  
    3 SIMAP similar genes for DNASE1L3 using alignment to 5 protein entries:     DNSL3_HUMAN (see all proteins):
    DNASE1L1    DNASE1    DNASE1L2

    DNASE1L3 for paralogs           About GeneDecksing



    Genomic Variants
    for DNASE1L3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/424 NCBI SNPs in DNASE1L3 are shown (see all 424)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1395974641,2
    		--58177956(+) CGTGAC/TGGTGG 2 -- ds50010--------
    rs1871057691,2
    		--58178052(+) CATTGC/TGTGTG 2 -- ds50010--------
    rs348825131,2
    		C,F,--58178146(+) TGACAG/-TGGAT 2 -- ds50014Minor allele frequency- -:0.38NA 8
    rs1166855741,2
    		F,--58178251(+) AGATAC/TAAAAG 2 -- ds50011Minor allele frequency- T:0.05WA 118
    rs1511619861,2
    		C,F,--58178478(+) AGGCCC/TTTGAA 4 K R mis11Minor allele frequency- T:0.00NA 4552
    rs1998263861,2
    		--58178561(+) ATGGAA/GATTAG 2 -- int10--------
    rs1434816581,2
    		--58178670(+) TAAGCA/GTCATT 2 -- int10--------
    rs1919203981,2
    		--58178771(+) CTTCAG/TTGGTG 2 -- int10--------
    rs1466794481,2
    		--58178802(+) CCCAT-/CTTTTT 2 -- int10--------
    rs112891171,2
    		C--58178803(+) TTTTTT/-TTTTT 2 -- int1 trp31Minor allele frequency- -:0.50NA 2

    HapMap Linkage Disequilibrium report for DNASE1L3 (58177984 - 58200424 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DNASE1L3: --
    Human Gene Mutation Database (HGMD): DNASE1L3

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    Disorders / Diseases
    for DNASE1L3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DNASE1L3 for disorders           About GeneDecksing

    OMIM gene information: 602244    OMIM disorders: --

    UniProtKB/Swiss-Prot: DNSL3_HUMAN, Q13609
  • Defects in DNASE1L3 are the cause of systemic lupus erythematosus type 16 (SLEB16) [MIM:614420]. A rare
    • autosomal recessive form of systemic lupus erythematosus with childhood onset, characterized by high frequency of
    anti-neutrophil cytoplasmic antibodies and lupus nephritis. Systemic lupus erythematosus is a chronic, relapsing,
    inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement
    of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure
    of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions,
    an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow

    7 diseases for DNASE1L3:    About MalaCards
    systemic lupus erythematosus    lupus erythematosus    lymphadenitis    burkitt's lymphoma
    osteosarcoma    adenocarcinoma    neuronitis

    2 Novoseek disease relationships for DNASE1L3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 29.5 2 12814251 (1), 15164982 (1)
    necrosis 0 2 15118903 (2)

    Human Genome Epidemiology (HuGE) Navigator: DNASE1L3 (3 documents)

    Export disorders for DNASE1L3 gene to outside databases

    Publications
    for DNASE1L3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DNASE1L3 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with DNASE1L3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of human DNase gamma: chromosomal localization of its gene and enzymatic properties of recombinant protein. (PubMed id 14646506)1, 2, 3, 9 Shiokawa D.... Tanuma S. (1998)
    2. Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages. (PubMed id 9714828)1, 2, 3, 9 Baron W.F....Baker K.P. (1998)
    3. Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I. (PubMed id 9205125)1, 2, 3 Rodriguez A.M....Schneider M.C. (1997)
    4. Loss-of-function variant in DNASE1L3 causes a familia l form of systemic lupus erythematosus. (PubMed id 22019780)1, 2 Al-Mayouf S.M....Alkuraya F.S. (2011)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Cloning and characterization of a novel human DNase. (PubMed id 9070308)1, 2 Zeng Z.... Li Y. (1997)
    8. Identification of two functional nuclear localization signals in DNase gamma and their roles in its apoptotic DNase activity. (PubMed id 12943533)1, 9 Shiokawa D....Tanuma S. (2003)
    9. Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis. (PubMed id 11141064)1, 9 Shiokawa D. and Tanuma S. (2001)
    10. DNase gamma-dependent and -independent apoptotic DNA fragmentations in Ramos Burkitt's lymphoma cell line. (PubMed id 19574717)1, 9 Mizuta R....Kitamura D. (2009)

    External Searches for DNASE1L3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing DNASE1L3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1776 HGNC: 2959 AceView: DNASE1L3 Ensembl:ENSG00000163687 euGenes: HUgn1776
    ECgene: DNASE1L3 H-InvDB: DNASE1L3

    Other Databases showing DNASE1L3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DNASE1L3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DNASE1L3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DNASE1L3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DNASE1L3 gene:
    Search GeneIP for patents involving DNASE1L3

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