Aliases for DNASE1L3 Gene
External Ids for DNASE1L3 Gene
Previous GeneCards Identifiers for DNASE1L3 Gene
This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
GeneCards Summary for DNASE1L3 Gene
DNASE1L3 (Deoxyribonuclease I-Like 3) is a Protein Coding gene. Diseases associated with DNASE1L3 include systemic lupus erythematosus 16 and hypocomplementemic urticarial vasculitis syndrome. GO annotations related to this gene include calcium ion binding and endodeoxyribonuclease activity, producing 5-phosphomonoesters. An important paralog of this gene is DNASE1.
UniProtKB/Swiss-Prot for DNASE1L3 Gene
Has DNA hydrolytic activity. Does not bind to actin. Cleaves chromatin DNA to nucleosomal units