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Aliases for DNASE1L3 Gene

Aliases for DNASE1L3 Gene

  • Deoxyribonuclease 1 Like 3 2 3
  • Deoxyribonuclease I Like 3 2 3 5
  • DNase Gamma 2 3 4
  • DNase I Homolog Protein DHP2 3 4
  • Deoxyribonuclease I-Like 3 3 4
  • Liver And Spleen DNase 3 4
  • DNase I-Like 3 3 4
  • LS-DNase 3 4
  • DNAS1L3 3 4
  • DHP2 3 4
  • LSD 3 4
  • Deoxyribonuclease I-Like III 3
  • DNase I Homolog Protein 2 3
  • Deoxyribonuclease Gamma 3
  • EC 61
  • EC 3.1.21.- 4
  • SLEB16 3

External Ids for DNASE1L3 Gene

Previous GeneCards Identifiers for DNASE1L3 Gene

  • GC03P057199
  • GC03M057547
  • GC03M058033
  • GC03M058135
  • GC03M058153

Summaries for DNASE1L3 Gene

Entrez Gene Summary for DNASE1L3 Gene

  • This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for DNASE1L3 Gene

DNASE1L3 (Deoxyribonuclease 1 Like 3) is a Protein Coding gene. Diseases associated with DNASE1L3 include Systemic Lupus Erythematosus 16 and Hypocomplementemic Urticarial Vasculitis Syndrome. GO annotations related to this gene include calcium ion binding and endodeoxyribonuclease activity. An important paralog of this gene is DNASE1L2.

UniProtKB/Swiss-Prot for DNASE1L3 Gene

  • Has DNA hydrolytic activity. Does not bind to actin. Cleaves chromatin DNA to nucleosomal units.

Gene Wiki entry for DNASE1L3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNASE1L3 Gene

Genomics for DNASE1L3 Gene

Regulatory Elements for DNASE1L3 Gene

Enhancers for DNASE1L3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DNASE1L3 on UCSC Golden Path with GeneCards custom track

Genomic Location for DNASE1L3 Gene

58,192,257 bp from pter
58,214,697 bp from pter
22,441 bases
Minus strand

Genomic View for DNASE1L3 Gene

Genes around DNASE1L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNASE1L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNASE1L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNASE1L3 Gene

Proteins for DNASE1L3 Gene

  • Protein details for DNASE1L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Deoxyribonuclease gamma
    Protein Accession:
    Secondary Accessions:
    • B2R8B1
    • B7Z707
    • O75803

    Protein attributes for DNASE1L3 Gene

    305 amino acids
    Molecular mass:
    35504 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DNASE1L3 Gene


neXtProt entry for DNASE1L3 Gene

Selected DME Specific Peptides for DNASE1L3 Gene

Post-translational modifications for DNASE1L3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNASE1L3 Gene

Domains & Families for DNASE1L3 Gene

Protein Domains for DNASE1L3 Gene

Suggested Antigen Peptide Sequences for DNASE1L3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DNase I family.
  • Belongs to the DNase I family.
genes like me logo Genes that share domains with DNASE1L3: view

No data available for Gene Families for DNASE1L3 Gene

Function for DNASE1L3 Gene

Molecular function for DNASE1L3 Gene

GENATLAS Biochemistry:
DNase I-like endonuclease,33kDa,expressed in liver and spleen,actin-resistant,specific to macrophage populations
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is about 7.2.;
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by zinc.
UniProtKB/Swiss-Prot Function:
Has DNA hydrolytic activity. Does not bind to actin. Cleaves chromatin DNA to nucleosomal units.

Enzyme Numbers (IUBMB) for DNASE1L3 Gene

Gene Ontology (GO) - Molecular Function for DNASE1L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004519 endonuclease activity IEA --
GO:0004520 endodeoxyribonuclease activity IEA --
GO:0004536 deoxyribonuclease activity TAS 9070308
GO:0005509 calcium ion binding TAS 9205125
genes like me logo Genes that share ontologies with DNASE1L3: view
genes like me logo Genes that share phenotypes with DNASE1L3: view

Human Phenotype Ontology for DNASE1L3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DNASE1L3 Gene

MGI Knock Outs for DNASE1L3:

Animal Model Products

  • Taconic Biosciences Mouse Models for DNASE1L3

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for DNASE1L3 Gene

Localization for DNASE1L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNASE1L3 Gene

Nucleus. Note=May first pass through the ER membrane before being imported in the nucleus.

Subcellular locations from

Jensen Localization Image for DNASE1L3 Gene COMPARTMENTS Subcellular localization image for DNASE1L3 gene
Compartment Confidence
nucleus 5
extracellular 3
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DNASE1L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with DNASE1L3: view

Pathways & Interactions for DNASE1L3 Gene

SuperPathways for DNASE1L3 Gene

No Data Available

Interacting Proteins for DNASE1L3 Gene

Selected Interacting proteins: Q13609-DNSL3_HUMAN for DNASE1L3 Gene via IID

Gene Ontology (GO) - Biological Process for DNASE1L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006259 DNA metabolic process TAS 9070308
GO:0006309 apoptotic DNA fragmentation IEA,IBA --
GO:0010623 programmed cell death involved in cell development IEA --
genes like me logo Genes that share ontologies with DNASE1L3: view

No data available for Pathways by source and SIGNOR curated interactions for DNASE1L3 Gene

Drugs & Compounds for DNASE1L3 Gene

(2) Drugs for DNASE1L3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
Magnesium Nutra 0

(2) Additional Compounds for DNASE1L3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DNASE1L3: view

Transcripts for DNASE1L3 Gene

Unigene Clusters for DNASE1L3 Gene

Deoxyribonuclease I-like 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNASE1L3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP3: -
SP4: - -

Relevant External Links for DNASE1L3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNASE1L3 Gene

mRNA expression in normal human tissues for DNASE1L3 Gene

mRNA differential expression in normal tissues according to GTEx for DNASE1L3 Gene

This gene is overexpressed in Spleen (x15.3) and Liver (x9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DNASE1L3 Gene

Protein tissue co-expression partners for DNASE1L3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNASE1L3 Gene:


SOURCE GeneReport for Unigene cluster for DNASE1L3 Gene:


mRNA Expression by UniProt/SwissProt for DNASE1L3 Gene:

Tissue specificity: Liver and spleen.
genes like me logo Genes that share expression patterns with DNASE1L3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein differential expression in normal tissues for DNASE1L3 Gene

Orthologs for DNASE1L3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DNASE1L3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DNASE1L3 34
  • 88.89 (n)
  • 88.41 (a)
  • 85 (a)
(Canis familiaris)
Mammalia DNASE1L3 34
  • 88.93 (n)
  • 87.31 (a)
  • 84 (a)
(Mus musculus)
Mammalia Dnase1l3 34
  • 83.77 (n)
  • 81.58 (a)
Dnase1l3 16
Dnase1l3 35
  • 80 (a)
(Pan troglodytes)
Mammalia DNASE1L3 34
  • 99.02 (n)
  • 98.69 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Dnase1l3 34
  • 85.27 (n)
  • 84.39 (a)
(Monodelphis domestica)
Mammalia DNASE1L3 35
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 67 (a)
-- 35
  • 64 (a)
(Gallus gallus)
Aves DNASE1L3 34
  • 65.98 (n)
  • 58.28 (a)
  • 56 (a)
(Anolis carolinensis)
Reptilia DNASE1L3 35
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnase1l3 34
  • 65.24 (n)
  • 59.79 (a)
MGC76250 34
African clawed frog
(Xenopus laevis)
Amphibia drng-A-prov 34
(Danio rerio)
Actinopterygii dnase1l3 34
  • 55.76 (n)
  • 50.72 (a)
dnase1l3l 35
  • 42 (a)
zgc:101000 35
  • 44 (a)
zgc:77816 35
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
-- 35
  • 43 (a)
-- 35
  • 32 (a)
-- 35
  • 31 (a)
Species where no ortholog for DNASE1L3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNASE1L3 Gene

Gene Tree for DNASE1L3 (if available)
Gene Tree for DNASE1L3 (if available)

Paralogs for DNASE1L3 Gene

Paralogs for DNASE1L3 Gene

(3) SIMAP similar genes for DNASE1L3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DNASE1L3: view

Variants for DNASE1L3 Gene

Sequence variations from dbSNP and Humsavar for DNASE1L3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs763778721 A breast cancer sample 58,210,852(+) GGCCA(C/G)GGCGC reference, missense
rs74350392 A breast cancer sample 58,205,547(+) TATGC(A/C/G)TCTCC intron-variant, reference, missense
VAR_036081 A colorectal cancer sample
rs12491947 - 58,205,503(+) TATGT(C/G/T)TTTCT intron-variant, reference, missense
rs35677470 - 58,197,909(+) CAAGC(A/C/G)GATGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DNASE1L3 Gene

Variant ID Type Subtype PubMed ID
esv3568767 CNV loss 25503493
nsv1001814 CNV gain 25217958
nsv528147 CNV gain 19592680
nsv834703 CNV gain 17160897

Variation tolerance for DNASE1L3 Gene

Residual Variation Intolerance Score: 80% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.70; 57.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNASE1L3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNASE1L3 Gene

Disorders for DNASE1L3 Gene

MalaCards: The human disease database

(7) MalaCards diseases for DNASE1L3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
systemic lupus erythematosus 16
  • sleb16
hypocomplementemic urticarial vasculitis syndrome
  • hypocomplementemic urticarial vasculitis
lupus erythematosus
  • systemic lupus erythematosus
  • acute epiglottitis
systemic lupus erythematosus
  • lupus nephritis
- elite association - COSMIC cancer census association via MalaCards


  • Systemic lupus erythematosus 16 (SLEB16) [MIM:614420]: A rare autosomal recessive form of systemic lupus erythematosus with childhood onset, characterized by high frequency of anti-neutrophil cytoplasmic antibodies and lupus nephritis. Systemic lupus erythematosus is a chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269 PubMed:22019780}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for DNASE1L3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DNASE1L3: view

No data available for Genatlas for DNASE1L3 Gene

Publications for DNASE1L3 Gene

  1. Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages. (PMID: 9714828) Baron W.F. … Baker K.P. (Gene 1998) 2 3 4 22 65
  2. cDNA cloning of human DNase gamma: chromosomal localization of its gene and enzymatic properties of recombinant protein. (PMID: 14646506) Shiokawa D. … Tanuma S. (Apoptosis 1998) 2 3 4 22 65
  3. Caucasian-specific allele in non-synonymous single nucleotide polymorphisms of the gene encoding deoxyribonuclease I-like 3, potentially relevant to autoimmunity, produces an inactive enzyme. (PMID: 19559017) Ueki M. … Yasuda T. (Clin. Chim. Acta 2009) 3 22 46 65
  4. Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I. (PMID: 9205125) Rodriguez A.M. … Schneider M.C. (Genomics 1997) 2 3 4 65
  5. Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus. (PMID: 22019780) Al-Mayouf S.M. … Alkuraya F.S. (Nat. Genet. 2011) 3 4 65

Products for DNASE1L3 Gene

Sources for DNASE1L3 Gene

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