Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DNASE1L3 Gene

protein-coding   GIFtS: 56
GCID: GC03M058153

Deoxyribonuclease I-Like 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Deoxyribonuclease I-Like 31 2 3     Liver And Spleen DNase2 3
DNase Gamma1 2 3     SLEB162 5
DHP22 3     Deoxyribonuclease Gamma2
DNAS1L32 3     Deoxyribonuclease I-Like III2
LS-DNase2 3     DNase I Homolog Protein 22
LSD2 3     EC 3.1.21.-3
DNase I Homolog Protein DHP22 3     EC 3.1.21.18
DNase I-Like 32 3     

External Ids:    HGNC: 29591   Entrez Gene: 17762   Ensembl: ENSG000001636877   OMIM: 6022445   UniProtKB: Q136093   

Export aliases for DNASE1L3 gene to outside databases

Previous GC identifers: GC03P057199 GC03M057547 GC03M058033 GC03M058135


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DNASE1L3 Gene:
This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited
by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic
lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed
for this gene. (provided by RefSeq, Feb 2012)

GeneCards Summary for DNASE1L3 Gene:
DNASE1L3 (deoxyribonuclease I-like 3) is a protein-coding gene. Diseases associated with DNASE1L3 include hypocomplementemic urticarial vasculitis syndrome, and systemic lupus erythematosus 16. GO annotations related to this gene include endodeoxyribonuclease activity, producing 5'-phosphomonoesters and calcium ion binding. An important paralog of this gene is DNASE1L2.

UniProtKB/Swiss-Prot: DNSL3_HUMAN, Q13609
Function: Has DNA hydrolytic activity. Does not bind to actin. Cleaves chromatin DNA to nucleosomal units

Gene Wiki entry for DNASE1L3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNASE1L3 gene promoter:
         c-Fos   AP-1   AML1a   JunB   Fra-1   FosB   JunD   FOXO4   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): DNASE1L3 promoter sequence
   Search Chromatin IP Primers for DNASE1L3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNASE1L3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.3   Ensembl cytogenetic band:  3p14.3   HGNC cytogenetic band: 3p14.3

DNASE1L3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNASE1L3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M058153:  view genomic region     (about GC identifiers)

Start:
58,177,984 bp from pter      End:
58,200,424 bp from pter
Size:
22,441 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DNSL3_HUMAN, Q13609 (See protein sequence)
Recommended Name: Deoxyribonuclease gamma precursor  
Size: 305 amino acids; 35504 Da
Cofactor: Calcium
Cofactor: Magnesium
Secondary accessions: B2R8B1 B7Z707 O75803
Alternative splicing: 2 isoforms:  Q13609-1   Q13609-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for DNASE1L3: NX_Q13609

Explore proteomics data for DNASE1L3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for DNASE1L3 (Q13609)
     CAYDRIV  SDHFPVE  FSREPFVV  GDFNAGCSYV 


    See DNASE1L3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243489.1  NP_004935.1  

    ENSEMBL proteins: 
     ENSP00000419052   ENSP00000417047   ENSP00000417976   ENSP00000378053   ENSP00000418113  
     ENSP00000418509   ENSP00000316193  

    DNASE1L3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for DNASE1L3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DNASE1L3
    GenScript Custom Purified and Recombinant Proteins Services for DNASE1L3
    Novus Biologicals DNASE1L3 Proteins
    Novus Biologicals DNASE1L3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DNASE1L3

    DNASE1L3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for DNASE1L3
    OriGene Custom Antibody Services for DNASE1L3
    Novus Biologicals DNASE1L3 Antibodies
    Abcam antibodies for DNASE1L3
    Cloud-Clone Corp. Antibodies for DNASE1L3
    ThermoFisher Antibody for DNASE1L3
    LSBio Antibodies in human, mouse, rat for DNASE1L3

    DNASE1L3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DNASE1L3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DNASE1L3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DNASE1L3
    Cloud-Clone Corp. CLIAs for DNASE1L3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR018057 Deoxyribonuclease-1_AS
     IPR016202 DNase_I
     IPR005135 Endo/exonuclease/phosphatase

    Graphical View of Domain Structure for InterPro Entry Q13609

    ProtoNet protein and cluster: Q13609

    1 Blocks protein domain: IPB008185 Deoxyribonuclease I

    UniProtKB/Swiss-Prot: DNSL3_HUMAN, Q13609
    Similarity: Belongs to the DNase I family


    DNASE1L3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DNSL3_HUMAN, Q13609
    Function: Has DNA hydrolytic activity. Does not bind to actin. Cleaves chromatin DNA to nucleosomal units
    Enzyme regulation: Inhibited by zinc
    Biophysicochemical properties: pH dependence: Optimum pH is about 7.2;

         Genatlas biochemistry entry for DNASE1L3:
    DNase I-like endonuclease,33kDa,expressed in liver and spleen,actin-resistant,specific to macrophage populations

         Enzyme Numbers (IUBMB): EC 3.1.21.-1 EC 3.1.21.12

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004519endonuclease activity ----
    GO:0004520endodeoxyribonuclease activity ----
    GO:0004536deoxyribonuclease activity TAS9070308
    GO:0005509calcium ion binding TAS9205125
         
    DNASE1L3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNASE1L3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DNASE1L3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DNASE1L3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DNASE1L3

    miRNA
    Products:
        
    miRTarBase miRNAs that target DNASE1L3:
    hsa-mir-335-5p (MIRT016727)

    Block miRNA regulation of human, mouse, rat DNASE1L3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DNASE1L3
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DNASE1L3
    Predesigned siRNA for gene silencing in human, mouse, rat DNASE1L3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DNASE1L3

    Clone
    Products:
         
    OriGene clones in human, mouse for DNASE1L3 (see all 8)
    OriGene ORF clones in mouse, rat for DNASE1L3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DNASE1L3 (NM_004944)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNASE1L3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNASE1L3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DNASE1L3
    Browse ESI BIO Cell Lines and PureStem Progenitors for DNASE1L3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNASE1L3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DNSL3_HUMAN, Q13609: Nucleus. Note=May first pass through the ER membrane before being imported in the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular2
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    DNASE1L3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DNASE1L3
    Interactions:

        Search GeneGlobe Interaction Network for DNASE1L3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for DNASE1L3 (Q136093 ENSP000003161934) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADAMTSL4Q6UY143I2D: score=1 
    AICDAENSP000002293354STRING: ENSP00000229335
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006259DNA metabolic process TAS9070308
    GO:0006308DNA catabolic process ----
    GO:0006309apoptotic DNA fragmentation IEA--
    GO:0010623developmental programmed cell death IEA--

    DNASE1L3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNASE1L3 (DNSL3)

    2 HMDB Compounds for DNASE1L3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--

    2 Novoseek inferred chemical compound relationships for DNASE1L3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aurintricarboxylic acid 76.6 1 14556310 (1)
    paraffin 24.2 3 15118903 (1), 12802584 (1)



    DNASE1L3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DNASE1L3 gene (2 alternative transcripts): 
    NM_001256560.1  NM_004944.3  

    Unigene Cluster for DNASE1L3:

    Deoxyribonuclease I-like 3
    Hs.476453  [show with all ESTs]
    Unigene Representative Sequence: AK301263
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486455 ENST00000483681(uc003djo.1 uc011bfd.1 uc003djq.1)
    ENST00000477209 ENST00000394549 ENST00000461914 ENST00000460422 ENST00000463694
    ENST00000318316(uc003djp.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DNASE1L3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DNASE1L3
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DNASE1L3
    Predesigned siRNA for gene silencing in human, mouse, rat DNASE1L3
    Clone
    Products:
         
    OriGene clones in human, mouse for DNASE1L3 (see all 8)
    OriGene ORF clones in mouse, rat for DNASE1L3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DNASE1L3 (NM_004944)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNASE1L3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNASE1L3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DNASE1L3
    OriGene qSTAR qPCR primer pairs in human, mouse for DNASE1L3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNASE1L3
      QuantiTect SYBR Green Assays in human, mouse, rat DNASE1L3
      QuantiFast Probe-based Assays in human, mouse, rat DNASE1L3

    Additional mRNA sequence: 

    AF047354.1 AK301263.1 AK313303.1 BC015831.1 U56814.1 

    9 DOTS entries:

    DT.91680725  DT.112581  DT.95166001  DT.99968742  DT.101977647  DT.106261  DT.75131550  DT.95166002 
    DT.99933446 

    Selected AceView cDNA sequences (see all 86):

    CB161995 CA449306 AI767476 AW025144 U56814 BQ710632 AW827162 CB164149 
    CR607614 CK300923 BE048177 CR602169 AI591302 BG566893 BP340512 AL546432 
    BC015831 BI460950 AW275495 AK097120 BX281999 BI834035 BI833952 BI838188 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DNASE1L3    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
    SP1:        -                                                                                 
    SP2:                                                                                          
    SP3:                                                                                -         
    SP4:                          -     -                                                         


    ECgene alternative splicing isoforms for DNASE1L3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DNASE1L3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGACTTCA
    DNASE1L3 Expression
    About this image


    DNASE1L3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Liver (Hepatobiliary System)    fully expand to see all 3 entries
             Periportal Hepatocytes Liver Lobule
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Mature B-Cells Peripheral Blood
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    DNASE1L3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNASE1L3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.476453

    UniProtKB/Swiss-Prot: DNSL3_HUMAN, Q13609
    Tissue specificity: Liver and spleen

        Custom PCR Arrays for DNASE1L3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DNASE1L3
    OriGene qSTAR qPCR primer pairs in human, mouse for DNASE1L3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNASE1L3
    QuantiTect SYBR Green Assays in human, mouse, rat DNASE1L3
    QuantiFast Probe-based Assays in human, mouse, rat DNASE1L3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNASE1L3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for DNASE1L3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnase1l31 , 5 deoxyribonuclease 1-like 31, 5 83.77(n)1
    81.58(a)1
      14 (4.67 cM)5
    134211  NM_007870.31  NP_031896.31 
     79645335 
    chicken
    (Gallus gallus)
    Aves DNASE1L31 deoxyribonuclease I-like 3 65.98(n)
    58.28(a)
      416008  NM_001034815.1  NP_001029987.1 
    lizard
    (Anolis carolinensis)
    Reptilia DNASE1L36
    deoxyribonuclease I-like 3
    57(a)
    1 ↔ 1
    2(163718148-163735992)
    African clawed frog
    (Xenopus laevis)
    Amphibia drng-A-prov2 deoxyribonuclease gamma 77.12(n)    AF059612.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC056304.12   -- 72.83(n)    BC056304.1 


    ENSEMBL Gene Tree for DNASE1L3 (if available)
    TreeFam Gene Tree for DNASE1L3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DNASE1L3 gene
    DNASE1L22  DNASE12  DNASE1L12  
    3 SIMAP similar genes for DNASE1L3 using alignment to 4 protein entries:     DNSL3_HUMAN (see all proteins):
    DNASE1L1    DNASE1    DNASE1L2

    DNASE1L3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DNASE1L3 (see all 551)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360814
    A colorectal cancer sample4--see VAR_0360812 Y S mis40--------
    VAR_0360804
    A breast cancer sample4--see VAR_0360802 G R mis40--------
    VAR_0360794
    A breast cancer sample4--see VAR_0360792 L V mis40--------
    rs1395974641,2
    C--58129363(+) CGTGAC/TGGTGG 2 -- ds50010--------
    rs1871057691,2
    --58129459(+) CATTGC/TGTGTG 2 -- ds50010--------
    rs348825131,2
    C,F--58129553(+) TGACAG/-TGGAT 2 -- ds50014Minor allele frequency- -:0.38NA 8
    rs774357151,2
    F--58129655(+) GAGAGA/TTACAA 2 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1166855741,2
    C,F--58129658(+) AGATAC/TAAAAG 2 -- ds50011Minor allele frequency- T:0.05WA 118
    rs1511619861,2
    C,F--58129885(+) AGGCCC/TTTGAA 4 K R mis11Minor allele frequency- T:0.00NA 4552
    rs1998263861,2
    --58129968(+) ATGGAA/GATTAG 2 -- int10--------

    HapMap Linkage Disequilibrium report for DNASE1L3 (58177984 - 58200424 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DNASE1L3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834703CNV Gain17160897
    nsv528147CNV Gain19592680

    Human Gene Mutation Database (HGMD): DNASE1L3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNASE1L3
    DNA2.0 Custom Variant and Variant Library Synthesis for DNASE1L3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602244   
    OMIM disorders: 614420  
    UniProtKB/Swiss-Prot: DNSL3_HUMAN, Q13609
  • Systemic lupus erythematosus 16 (SLEB16) [MIM:614420]: A rare autosomal recessive form of systemic lupus
    erythematosus with childhood onset, characterized by high frequency of anti-neutrophil cytoplasmic antibodies and
    lupus nephritis. Systemic lupus erythematosus is a chronic, relapsing, inflammatory, and often febrile
    multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints,
    kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory
    mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated
    erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • Selected diseases for DNASE1L3 (see all 22):    
    About MalaCards
    hypocomplementemic urticarial vasculitis syndrome    systemic lupus erythematosus 16    lymphadenitis    pediatric systemic lupus erythematosus
    systemic lupus erythematosus    lupus erythematosus    lupus nephritis    nephritis
    burkitt's lymphoma    breast and colorectal cancer    osteosarcoma    tonsillitis
    multiple myeloma    myeloma    adenocarcinoma    cerebritis
    colorectal cancer    thyroiditis    neuronitis    endotheliitis


    DNASE1L3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for DNASE1L3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 29.5 2 12814251 (1), 15164982 (1)
    necrosis 0 2 15118903 (2)

    Genetic Association Database (GAD): DNASE1L3
    Human Genome Epidemiology (HuGE) Navigator: DNASE1L3 (3 documents)

    Export disorders for DNASE1L3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DNASE1L3 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with DNASE1L3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of human DNase gamma: chromosomal localization of its gene and enzymatic properties of recombinant protein. (PubMed id 14646506)1, 2, 3, 9 Shiokawa D.... Tanuma S. (Apoptosis 1998)
    2. Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages. (PubMed id 9714828)1, 2, 3, 9 Baron W.F....Baker K.P. (Gene 1998)
    3. Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I. (PubMed id 9205125)1, 2, 3 Rodriguez A.M....Schneider M.C. (Genomics 1997)
    4. Caucasian-specific allele in non-synonymous single nucleotide polymorphisms of the gene encoding deoxyribonuclease I-like 3, potentially relevant to autoimmunity, produces an inactive enzyme. (PubMed id 19559017)1, 4, 9 Ueki M....Yasuda T. ( international journal of clinical chemistry 2009)
    5. Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus. (PubMed id 22019780)1, 2 Al-Mayouf S.M.... Alkuraya F.S. (Nat. Genet. 2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Cloning and characterization of a novel human DNase. (PubMed id 9070308)1, 2 Zeng Z.... Li Y. (Biochem. Biophys. Res. Commun. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1776 HGNC: 2959 AceView: DNASE1L3 Ensembl:ENSG00000163687 euGenes: HUgn1776
    ECgene: DNASE1L3 H-InvDB: DNASE1L3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DNASE1L3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DNASE1L3 gene:
    Search GeneIP for patents involving DNASE1L3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for DNASE1L3   OriGene RNAi products in human, mouse, rat for DNASE1L3  
     OriGene qPCR primer pairs and template standards for DNASE1L3   OriGene Protein Over-expression Lysate for DNASE1L3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DNASE1L3  
     OriGene qSTAR qPCR primer pairs in human, mouse for DNASE1L3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for DNASE1L3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DNASE1L3   OriGene Custom Protein Services for DNASE1L3  

     
     
     Block miRNA regulation of human, mouse, rat DNASE1L3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DNASE1L3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNASE1L3 Predesigned siRNA for gene silencing in human, mouse, rat DNASE1L3
     QuantiFast Probe-based Assays in human, mouse, rat DNASE1L3 QuantiTect SYBR Green Assays in human, mouse, rat DNASE1L3
     Custom PCR Arrays for DNASE1L3 Search Chromatin IP Primers for DNASE1L3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNASE1L3  Search GeneGlobe Interaction Network for DNASE1L3
     Regulatory tfbs in DNASE1L3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for DNASE1L3 GenScript cDNA clones with any tag delivered in your preferred vector for DNASE1L3
     GenScript Custom Assay Services for DNASE1L3 GenScript Custom overexpressing Cell Line Services for DNASE1L3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DNASE1L3 (DNSL3)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DNASE1L3 antibodies
     DNASE1L3 proteins
     DNASE1L3 lysates
     Antibodies for DNASE1L3
     See all of Abcam's Antibodies, Kits and Proteins for DNASE1L3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DNASE1L3
     Antibodies for DNASE1L3
     ELISAs for DNASE1L3
     CLIAs for DNASE1L3



     Browse ESI BIO Cell Lines and PureStem Progenitors for DNASE1L3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNASE1L3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for DNASE1L3
     SwitchGear Promoter luciferase reporter plasmids for DNASE1L3
     ThermoFisher Antibody for DNASE1L3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNASE1L3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNASE1L3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DNASE1L3
     LSBio Antibodies in human, mouse, rat for DNASE1L3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DNASE1L3 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4