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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DNASE1L2 Gene

protein-coding   GIFtS: 51
GCID: GC16P002285

Deoxyribonuclease I-Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Deoxyribonuclease I-Like 21 2 3     Deoxyribonuclease-1-Like 22
DNAS1L22 3     DHP13
DNase I Homolog Protein DHP12 3     EC 3.1.21.-3
DNase I-Like 22 3     EC 3.1.21.18

External Ids:    HGNC: 29581   Entrez Gene: 17752   Ensembl: ENSG000001679687   OMIM: 6026225   UniProtKB: Q928743   

Export aliases for DNASE1L2 gene to outside databases

Previous GC identifers: GC16M002497 GC16P002311 GC16P002226 GC16P002286 GC16P002212


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DNASE1L2 Gene: 
DNASE1L2 (deoxyribonuclease I-like 2) is a protein-coding gene. Diseases associated with DNASE1L2 include polycystic kidney disease, and kidney disease. GO annotations related to this gene include endodeoxyribonuclease activity, producing 5'-phosphomonoesters and calcium ion binding. An important paralog of this gene is DNASE1L3.

Gene Wiki entry for DNASE1L2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DNASE1L2 gene promoter:
         ER-alpha   AML1a   p53   Lmo2   Tal-1beta   Meis-1b   E47   Meis-1a   Pax-4a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DNASE1L2 promoter sequence
   Search SABiosciences Chromatin IP Primers for DNASE1L2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNASE1L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

DNASE1L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNASE1L2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P002285:  view genomic region     (about GC identifiers)

Start:
2,285,817 bp from pter      End:
2,288,712 bp from pter
Size:
2,896 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DNSL2_HUMAN, Q92874 (See protein sequence)
Recommended Name: Deoxyribonuclease-1-like 2 precursor  
Size: 299 amino acids; 32853 Da
Subcellular location: Secreted (Potential)

Explore the universe of human proteins at neXtProt for DNASE1L2: NX_Q92874

Explore proteomics data for DNASE1L2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92874

  • 4/5 DME Specific Peptides for DNASE1L2 (Q92874) (see all 5)
     CAYDRIV  SDHFPVE  GDFNADC  FSREPFVV 

    DNASE1L2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DNASE1L2 Protein Expression
    REFSEQ proteins: NP_001365.1  
    ENSEMBL proteins: 
     ENSP00000454562   ENSP00000316938   ENSP00000455358   ENSP00000371874   ENSP00000455478  

    Human Recombinant Protein Products for DNASE1L2: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DNASE1L2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    DNASE1L2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR016202 DNase_I-like
     IPR008185 DNase_I_euk
     IPR018057 Deoxyribonuclease-1_AS
     IPR005135 Endo/exonuclease/phosphatase

    Graphical View of Domain Structure for InterPro Entry Q92874

    ProtoNet protein and cluster: Q92874

    1 Blocks protein domain: IPB008185 Deoxyribonuclease I

    UniProtKB/Swiss-Prot: DNSL2_HUMAN, Q92874
    Similarity: Belongs to the DNase I family


    DNASE1L2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for DNASE1L2:
    DNase I-like endonuclease 2,expressed in brain

         Enzyme Numbers (IUBMB): EC 3.1.21.-1 EC 3.1.21.12

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS9205125
    GO:0004536deoxyribonuclease activity TAS9205125
    GO:0005509calcium ion binding TAS9205125
    GO:0016888endodeoxyribonuclease activity, producing 5'-phosphomonoesters IEA--
         
    DNASE1L2 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dnase1l2):
     behavior/neurological  cellular  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  skeleton 

    DNASE1L2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DNASE1L2: Dnase1l2tm1(KOMP)Wtsi Dnase1l2tm1Eckh

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DNASE1L2 
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    hsa-miR-1184 hsa-miR-1205
    SwitchGear 3'UTR luciferase reporter plasmidDNASE1L2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNASE1L2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNASE1L2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for DNASE1L2 (Q928741, 2, 3 ENSP000003169384) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005191, 2, 3, ENSP000003614234EBI-1751995,EBI-375543 MINT-8110251 I2D: score=3 STRING: ENSP00000361423
    FYNP062411, 2, 3, ENSP000003576564EBI-1751995,EBI-515315 MINT-8111139 I2D: score=3 STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006259DNA metabolic process TAS9205125
    GO:0006308DNA catabolic process IEA--

    DNASE1L2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DNASE1L2 (DNSL2)

    Search CenterWatch for drugs/clinical trials and news about DNASE1L2 / DNSL2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DNASE1L2 gene: 
    NM_001374.2  

    Unigene Cluster for DNASE1L2:

    Deoxyribonuclease I-like 2
    Hs.103503  [show with all ESTs]
    Unigene Representative Sequence: AK098028
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000564065(uc002cpn.3 uc002cpo.3) ENST00000320700(uc002cpp.3 uc002cpq.3)
    ENST00000567494 ENST00000382437 ENST00000569184
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate DNASE1L2:
    hsa-miR-1184 hsa-miR-1205
    SwitchGear 3'UTR luciferase reporter plasmidDNASE1L2 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of DNASE1L2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNASE1L2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNASE1L2

    Additional mRNA sequence: 

    AK098028.1 AY298957.1 BC035205.1 BC063710.1 U62647.1 

    5 DOTS entries:

    DT.100019786  DT.120702799  DT.100778478  DT.91664836  DT.91650498 

    24/153 AceView cDNA sequences (see all 153):

    BC035205 AK098028 BU957083 BU539326 NM_001374 BC014068 BC080524 BU501086 
    AY298957 AW515664 Z38690 BM713890 BI223566 BX284025 CA405900 BM676507 
    AI675620 BM796095 AI420452 CA422408 BX283985 BC063710 CA488104 AW451082 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for DNASE1L2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
    SP1:                                          
    SP2:        -                                 


    ECgene alternative splicing isoforms for DNASE1L2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DNASE1L2 expression in normal human tissues (normalized intensities)      DNASE1L2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGGGTGCAG
    DNASE1L2 Expression
    About this image


    DNASE1L2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Epidermis (Integumentary System)    fully expand to see all 2 entries
             Granular Keratinocytes Stratified Epidermis
     
     Hair (Integumentary System)
             Fetal Matrix Cells Hair Follicle
     
     Prostate (Endocrine System)

     -- (Integumentary System)
             SKIN   

    See DNASE1L2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DNASE1L2

    SOURCE GeneReport for Unigene cluster: Hs.103503

    UniProtKB/Swiss-Prot: DNSL2_HUMAN, Q92874
    Tissue specificity: Brain

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNASE1L2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for DNASE1L2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnase1l21 , 5 deoxyribonuclease 1-like 21, 5 79.5(n)1
    83.09(a)1
      17 (12.39 cM)5
    667051  NM_025718.31  NP_079994.21 
     244400815 
    chicken
    (Gallus gallus)
    Aves DNASE1L21 deoxyribonuclease I-like 2 73.26(n)
    69.2(a)
      427682  XM_425256.2  XP_425256.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    57(a)
    57(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    GL343691.1(64032-73437)
    AAWZ02036670(16766-23809)
    zebrafish
    (Danio rerio)
    Actinopterygii dnase16
    deoxyribonuclease I
    50(a)
    1 → many
    3(27930094-27935576)


    ENSEMBL Gene Tree for DNASE1L2 (if available)
    TreeFam Gene Tree for DNASE1L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DNASE1L2 gene
    DNASE1L32  DNASE12  DNASE1L12  
    3 SIMAP similar genes for DNASE1L2 using alignment to 4 protein entries:     DNSL2_HUMAN (see all proteins):
    DNASE1    DNASE1L3    DNASE1L1

    DNASE1L2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/118 SNPs in DNASE1L2 are shown (see all 118)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1495374161,2
    --2286261(+) CGGTTC/TTGGGA 1 -- us2k10--------
    rs1836905751,2
    --2286322(+) TGGGGA/GTCTCC 1 -- us2k10--------
    rs1883629931,2
    --2286325(+) GGGTCC/TCCATG 1 -- us2k10--------
    rs1926522631,2
    --2286394(+) GCAGCC/TCGGCC 1 -- us2k10--------
    rs1848450101,2
    --2286490(+) ACACGC/TCCGCA 1 -- ut510--------
    rs1463975271,2
    C--2286567(+) GTGAG-/TCTC  
            
    TCGGC
    1 -- int10--------
    rs31141301,2
    C,F,A--2286575(-) GGGCAG/ACCGAG 1 -- int18Minor allele frequency- A:0.48NA WA CSA 131
    rs1869071341,2
    C--2286579(+) GCTGCC/TCTGAG 1 -- int10--------
    rs1915175951,2
    C--2286876(+) GACCGA/CCGCGC 2 D A mis10--------
    rs2000322821,2
    C--2286970(+) GGGCCC/TGGGCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for DNASE1L2 (2285817 - 2288712 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for DNASE1L2 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2673834CNV Deletion23128226
    esv2422427CNV Duplication17116639
    dgv2545n71CNV Loss21882294
    dgv2563n71CNV Loss21882294
    dgv2546n71CNV Loss21882294
    nsv457351CNV Loss19166990
    dgv2557n71CNV Loss21882294
    nsv905139CNV Loss21882294
    dgv2540n71CNV Loss21882294
    dgv2550n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602622    OMIM disorders: --

    2 diseases for DNASE1L2:    About MalaCards
    polycystic kidney disease    kidney disease


    DNASE1L2 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: DNASE1L2 (1 document)

    Export disorders for DNASE1L2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DNASE1L2 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with DNASE1L2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I. (PubMed id 9205125)1, 2, 3 Rodriguez A.M....Schneider M.C. (1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The gene for autosomal dominant polycystic kidney disease lies in a 750-kb CpG-rich region. (PubMed id 1577479)1, 3 Germino G.G....Reeders S.T. (1992)
    4. DNase1L2 degrades nuclear DNA during corneocyte formation. (PubMed id 16902420)1, 9 Fischer H....Tschachler E. (2007)
    5. Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis. (PubMed id 11141064)1, 9 Shiokawa D. and Tanuma S. (2001)
    6. Five non-synonymous SNPs in the gene encoding human de oxyribonuclease I-like 2 implicated in terminal differentiation of keratinocytes reduce or abolish its activity. (PubMed id 23161465)1 Ueki M....Yasuda T. (2013)
    7. Global analysis of single nucleotide polymorphisms in the exons of human deoxyribonuclease I-like 1 and 2 genes. (PubMed id 20967767)1 Fujihara J....Takeshita H. (2010)
    8. Genetic and expression analysis of all non-synonymous single nucleotide polymorphisms in the human deoxyribonuclease I-like 1 and 2 genes. (PubMed id 20503202)1 Ueki M....Yasuda T. (2010)
    9. Terminal differentiation of nail matrix keratinocytes involves up-regulation of DNase1L2 but is independent of caspase-14 expression. (PubMed id 17490414)1 Jager K....Eckhart L. (2007)
    10. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1775 HGNC: 2958 AceView: DNASE1L2andE4F1 Ensembl:ENSG00000167968 euGenes: HUgn1775
    ECgene: DNASE1L2 H-InvDB: DNASE1L2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DNASE1L2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNASE1L2 gene:
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