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Aliases for DNASE1L2 Gene

Aliases for DNASE1L2 Gene

  • Deoxyribonuclease I-Like 2 2 3 4 5
  • DNase I Homolog Protein DHP1 3 4
  • DNase I-Like 2 3 4
  • DNAS1L2 3 4
  • EC 3.1.21.1 63
  • EC 3.1.21.- 4
  • DHP1 4

External Ids for DNASE1L2 Gene

Previous GeneCards Identifiers for DNASE1L2 Gene

  • GC16M002497
  • GC16P002311
  • GC16P002226
  • GC16P002286
  • GC16P002212
  • GC16P002285

Summaries for DNASE1L2 Gene

GeneCards Summary for DNASE1L2 Gene

DNASE1L2 (Deoxyribonuclease I-Like 2) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and deoxyribonuclease activity. An important paralog of this gene is DNASE1L1.

UniProtKB/Swiss-Prot for DNASE1L2 Gene

  • Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells.

Gene Wiki entry for DNASE1L2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNASE1L2 Gene

Genomics for DNASE1L2 Gene

Regulatory Elements for DNASE1L2 Gene

Genomic Location for DNASE1L2 Gene

Chromosome:
16
Start:
2,235,816 bp from pter
End:
2,238,711 bp from pter
Size:
2,896 bases
Orientation:
Plus strand

Genomic View for DNASE1L2 Gene

Genes around DNASE1L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNASE1L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNASE1L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNASE1L2 Gene

Proteins for DNASE1L2 Gene

  • Protein details for DNASE1L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92874-DNSL2_HUMAN
    Recommended name:
    Deoxyribonuclease-1-like 2
    Protein Accession:
    Q92874
    Secondary Accessions:
    • E9PBY4
    • Q6JVM2
    • Q6JVM3

    Protein attributes for DNASE1L2 Gene

    Size:
    299 amino acids
    Molecular mass:
    32853 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DNASE1L2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNASE1L2 Gene

Proteomics data for DNASE1L2 Gene at MOPED

Selected DME Specific Peptides for DNASE1L2 Gene

Post-translational modifications for DNASE1L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNASE1L2 Gene

Domains & Families for DNASE1L2 Gene

Protein Domains for DNASE1L2 Gene

Suggested Antigen Peptide Sequences for DNASE1L2 Gene

Graphical View of Domain Structure for InterPro Entry

Q92874

UniProtKB/Swiss-Prot:

DNSL2_HUMAN :
  • Belongs to the DNase I family.
Family:
  • Belongs to the DNase I family.
genes like me logo Genes that share domains with DNASE1L2: view

No data available for Gene Families for DNASE1L2 Gene

Function for DNASE1L2 Gene

Molecular function for DNASE1L2 Gene

GENATLAS Biochemistry:
DNase I-like endonuclease 2,expressed in brain
UniProtKB/Swiss-Prot Function:
Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells.
UniProtKB/Swiss-Prot Induction:
Up-regulated by inflammatory cytokines.

Enzyme Numbers (IUBMB) for DNASE1L2 Gene

Gene Ontology (GO) - Molecular Function for DNASE1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 9205125
GO:0016888 endodeoxyribonuclease activity, producing 5-phosphomonoesters IEA --
genes like me logo Genes that share ontologies with DNASE1L2: view
genes like me logo Genes that share phenotypes with DNASE1L2: view

Animal Models for DNASE1L2 Gene

MGI Knock Outs for DNASE1L2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DNASE1L2 Gene

Localization for DNASE1L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNASE1L2 Gene

Cytoplasm. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNASE1L2 Gene COMPARTMENTS Subcellular localization image for DNASE1L2 gene
Compartment Confidence
extracellular 4
nucleus 4
mitochondrion 3
cytosol 1
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for DNASE1L2 Gene

Pathways & Interactions for DNASE1L2 Gene

SuperPathways for DNASE1L2 Gene

No Data Available

Interacting Proteins for DNASE1L2 Gene

Gene Ontology (GO) - Biological Process for DNASE1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001942 hair follicle development IEA --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with DNASE1L2: view

No data available for Pathways by source and SIGNOR curated interactions for DNASE1L2 Gene

Drugs & Compounds for DNASE1L2 Gene

No Compound Related Data Available

Transcripts for DNASE1L2 Gene

Unigene Clusters for DNASE1L2 Gene

Deoxyribonuclease I-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNASE1L2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for DNASE1L2 Gene

GeneLoc Exon Structure for
DNASE1L2
ECgene alternative splicing isoforms for
DNASE1L2

Expression for DNASE1L2 Gene

mRNA expression in normal human tissues for DNASE1L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNASE1L2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x11.5) and Skin - Sun Exposed (Lower leg) (x9.0).

Protein differential expression in normal tissues from HIPED for DNASE1L2 Gene

This gene is overexpressed in Hair follicle (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DNASE1L2 Gene



SOURCE GeneReport for Unigene cluster for DNASE1L2 Gene Hs.103503

mRNA Expression by UniProt/SwissProt for DNASE1L2 Gene

Q92874-DNSL2_HUMAN
Tissue specificity: Preferentially expressed in the skin and up-regulated during keratinocytes differentiation. Highly abundant (at protein level) in the stratum granulosum.
genes like me logo Genes that share expression patterns with DNASE1L2: view

Protein tissue co-expression partners for DNASE1L2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for DNASE1L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DNASE1L2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNASE1L2 35
  • 86.45 (n)
  • 87.05 (a)
DNASE1L2 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnase1l2 35
  • 79.5 (n)
  • 83.09 (a)
Dnase1l2 16
Dnase1l2 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DNASE1L2 35
  • 93.77 (n)
  • 93.08 (a)
DNASE1L2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnase1l2 35
  • 79.38 (n)
  • 83.09 (a)
dog
(Canis familiaris)
Mammalia DNASE1L2 36
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNASE1L2 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 64 (a)
OneToMany
DNASE1 36
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia DNASE1L2 36
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dnase1 36
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
Species with no ortholog for DNASE1L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNASE1L2 Gene

ENSEMBL:
Gene Tree for DNASE1L2 (if available)
TreeFam:
Gene Tree for DNASE1L2 (if available)

Paralogs for DNASE1L2 Gene

Paralogs for DNASE1L2 Gene

(3) SIMAP similar genes for DNASE1L2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DNASE1L2: view

Variants for DNASE1L2 Gene

Sequence variations from dbSNP and Humsavar for DNASE1L2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs26841 -- 2,237,746(+) CAGAC(A/G)CGGCT intron-variant
rs26842 -- 2,238,887(+) CAAAC(A/G)CTCCC downstream-variant-500B
rs27620 -- 2,238,223(+) GGCCA(A/G)TGGTG intron-variant
rs160550 -- 2,237,214(+) TCTCC(A/G)CAGCG intron-variant
rs160551 -- 2,238,344(+) TGAGG(C/T)TCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNASE1L2 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2540n71 CNV Loss 21882294
dgv2544n71 CNV Loss 21882294
dgv2545n71 CNV Loss 21882294
dgv2546n71 CNV Loss 21882294
dgv2550n71 CNV Loss 21882294
nsv471072 CNV Loss 18288195
dgv2557n71 CNV Loss 21882294
dgv2563n71 CNV Loss 21882294
nsv457351 CNV Loss 19166990
nsv905132 CNV Loss 21882294
nsv905139 CNV Loss 21882294
esv2673834 CNV Deletion 23128226
dgv2567n71 CNV Loss 21882294
nsv905142 CNV Loss 21882294

Variation tolerance for DNASE1L2 Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNASE1L2 Gene

HapMap Linkage Disequilibrium report
DNASE1L2
Human Gene Mutation Database (HGMD)
DNASE1L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNASE1L2 Gene

Disorders for DNASE1L2 Gene

Relevant External Links for DNASE1L2

Human Genome Epidemiology (HuGE) Navigator
DNASE1L2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNASE1L2

No disorders were found for DNASE1L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNASE1L2 Gene

Publications for DNASE1L2 Gene

  1. Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I. (PMID: 9205125) Rodriguez A.M. … Schneider M.C. (Genomics 1997) 2 3 4 67
  2. DNase1L2 degrades nuclear DNA during corneocyte formation. (PMID: 16902420) Fischer H. … Tschachler E. (J. Invest. Dermatol. 2007) 3 23
  3. Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis. (PMID: 11141064) Shiokawa D. … Tanuma S. (Biochemistry 2001) 3 23
  4. The gene for autosomal dominant polycystic kidney disease lies in a 750-kb CpG-rich region. (PMID: 1577479) Germino G.G. … Reeders S.T. (Genomics 1992) 2 3
  5. Identification of functional SNPs potentially served as a genetic risk factor for the pathogenesis of parakeratosis in the gene encoding human deoxyribonuclease I-like 2 (DNase 1L2) implicated in terminal differentiation of keratinocytes. (PMID: 25576224) Ueki M. … Yasuda T. (Gene 2015) 3

Products for DNASE1L2 Gene

Sources for DNASE1L2 Gene

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