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Aliases for DNASE1L2 Gene

Aliases for DNASE1L2 Gene

  • Deoxyribonuclease 1 Like 2 2 3 5
  • DNase I Homolog Protein DHP1 3 4
  • Deoxyribonuclease I-Like 2 3 4
  • DNase I-Like 2 3 4
  • DNAS1L2 3 4
  • Deoxyribonuclease I Like 2 2
  • Deoxyribonuclease-1-Like 2 3
  • EC 3.1.21.1 61
  • EC 3.1.21.- 4
  • DHP1 4

External Ids for DNASE1L2 Gene

Previous GeneCards Identifiers for DNASE1L2 Gene

  • GC16M002497
  • GC16P002311
  • GC16P002226
  • GC16P002286
  • GC16P002212
  • GC16P002285

Summaries for DNASE1L2 Gene

GeneCards Summary for DNASE1L2 Gene

DNASE1L2 (Deoxyribonuclease 1 Like 2) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and deoxyribonuclease activity. An important paralog of this gene is DNASE1.

UniProtKB/Swiss-Prot for DNASE1L2 Gene

  • Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells.

Gene Wiki entry for DNASE1L2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNASE1L2 Gene

Genomics for DNASE1L2 Gene

Regulatory Elements for DNASE1L2 Gene

Enhancers for DNASE1L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F002427 0.9 FANTOM5 ENCODE 3.8 +193.4 193433 2.8 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF766 CBX5 TIGD7 MEFV IFT140 MTCO1P28 CCNF LOC652276 KCTD5 DNASE1L2 ELOB MLST8
GH16F002121 1 FANTOM5 Ensembl ENCODE 2.3 -109.7 -109665 9.7 HDGF ATF1 PKNOX1 SIN3A FEZF1 ZNF2 ZNF121 GLIS2 KLF7 ZNF263 ENSG00000261123 MLST8 ENSG00000261240 TSC2 NME3 DNASE1L2 NUBP2 NTHL1 SLC9A3R2 TBL3
GH16F001928 1.2 FANTOM5 Ensembl ENCODE 1.6 -306.1 -306093 1.8 ATF1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ZNF207 ZNF143 KLF13 IFT140 CCDC154 ERVK13-1 FAHD1 EME2 NME3 HN1L ENSG00000260447 SNHG19 HAGH
GH16F002230 1.2 Ensembl ENCODE 0.8 +0.2 246 11.1 ZNF76 KLF17 SIN3A FEZF1 RAD21 GLIS2 KLF7 EGR2 SP3 MIER2 ENSG00000261505 BRICD5 ENSG00000260051 ENSG00000260954 THOC6 ENSG00000255513 SNORA64 LOC105371055 SNORD60 MLST8
GH16F002226 0.5 ENCODE 0.4 -9.2 -9203 1.1 ELF3 ARID4B THRB ZSCAN9 RARA ZNF121 CREM THAP11 PAF1 ZNF362 E4F1 DNASE1L2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DNASE1L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DNASE1L2 Gene

Chromosome:
16
Start:
2,235,816 bp from pter
End:
2,238,711 bp from pter
Size:
2,896 bases
Orientation:
Plus strand

Genomic View for DNASE1L2 Gene

Genes around DNASE1L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNASE1L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNASE1L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNASE1L2 Gene

Proteins for DNASE1L2 Gene

  • Protein details for DNASE1L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92874-DNSL2_HUMAN
    Recommended name:
    Deoxyribonuclease-1-like 2
    Protein Accession:
    Q92874
    Secondary Accessions:
    • E9PBY4
    • Q6JVM2
    • Q6JVM3

    Protein attributes for DNASE1L2 Gene

    Size:
    299 amino acids
    Molecular mass:
    32853 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DNASE1L2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNASE1L2 Gene

Selected DME Specific Peptides for DNASE1L2 Gene

Post-translational modifications for DNASE1L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNASE1L2 Gene

Domains & Families for DNASE1L2 Gene

Protein Domains for DNASE1L2 Gene

Suggested Antigen Peptide Sequences for DNASE1L2 Gene

Graphical View of Domain Structure for InterPro Entry

Q92874

UniProtKB/Swiss-Prot:

DNSL2_HUMAN :
  • Belongs to the DNase I family.
Family:
  • Belongs to the DNase I family.
genes like me logo Genes that share domains with DNASE1L2: view

No data available for Gene Families for DNASE1L2 Gene

Function for DNASE1L2 Gene

Molecular function for DNASE1L2 Gene

GENATLAS Biochemistry:
DNase I-like endonuclease 2,expressed in brain
UniProtKB/Swiss-Prot Function:
Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells.
UniProtKB/Swiss-Prot Induction:
Up-regulated by inflammatory cytokines.

Enzyme Numbers (IUBMB) for DNASE1L2 Gene

Gene Ontology (GO) - Molecular Function for DNASE1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 9205125
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IEA --
GO:0004536 deoxyribonuclease activity IEA,TAS --
GO:0005509 calcium ion binding TAS 9205125
genes like me logo Genes that share ontologies with DNASE1L2: view
genes like me logo Genes that share phenotypes with DNASE1L2: view

Animal Models for DNASE1L2 Gene

MGI Knock Outs for DNASE1L2:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DNASE1L2 Gene

Localization for DNASE1L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNASE1L2 Gene

Cytoplasm. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNASE1L2 Gene COMPARTMENTS Subcellular localization image for DNASE1L2 gene
Compartment Confidence
extracellular 4
nucleus 4
mitochondrion 3
cytosol 1
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DNASE1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DNASE1L2: view

Pathways & Interactions for DNASE1L2 Gene

SuperPathways for DNASE1L2 Gene

No Data Available

Interacting Proteins for DNASE1L2 Gene

Gene Ontology (GO) - Biological Process for DNASE1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001942 hair follicle development IEA --
GO:0003335 corneocyte development IEA --
GO:0006259 DNA metabolic process TAS 9205125
GO:0006308 DNA catabolic process IEA --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with DNASE1L2: view

No data available for Pathways by source and SIGNOR curated interactions for DNASE1L2 Gene

Transcripts for DNASE1L2 Gene

Unigene Clusters for DNASE1L2 Gene

Deoxyribonuclease I-like 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNASE1L2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for DNASE1L2 Gene

GeneLoc Exon Structure for
DNASE1L2
ECgene alternative splicing isoforms for
DNASE1L2

Expression for DNASE1L2 Gene

mRNA expression in normal human tissues for DNASE1L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNASE1L2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x11.5) and Skin - Sun Exposed (Lower leg) (x9.0).

Protein differential expression in normal tissues from HIPED for DNASE1L2 Gene

This gene is overexpressed in Hair follicle (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DNASE1L2 Gene



Protein tissue co-expression partners for DNASE1L2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNASE1L2 Gene:

DNASE1L2

SOURCE GeneReport for Unigene cluster for DNASE1L2 Gene:

Hs.103503

mRNA Expression by UniProt/SwissProt for DNASE1L2 Gene:

Q92874-DNSL2_HUMAN
Tissue specificity: Preferentially expressed in the skin and up-regulated during keratinocytes differentiation. Highly abundant (at protein level) in the stratum granulosum.
genes like me logo Genes that share expression patterns with DNASE1L2: view

Primer Products

Orthologs for DNASE1L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DNASE1L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNASE1L2 34 35
  • 93.77 (n)
cow
(Bos Taurus)
Mammalia DNASE1L2 34 35
  • 86.45 (n)
mouse
(Mus musculus)
Mammalia Dnase1l2 34 16 35
  • 79.5 (n)
rat
(Rattus norvegicus)
Mammalia Dnase1l2 34
  • 79.38 (n)
oppossum
(Monodelphis domestica)
Mammalia DNASE1L2 35
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNASE1L2 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 64 (a)
OneToMany
DNASE1 35
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia DNASE1L2 35
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dnase1 35
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
Species where no ortholog for DNASE1L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNASE1L2 Gene

ENSEMBL:
Gene Tree for DNASE1L2 (if available)
TreeFam:
Gene Tree for DNASE1L2 (if available)

Paralogs for DNASE1L2 Gene

Paralogs for DNASE1L2 Gene

(3) SIMAP similar genes for DNASE1L2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DNASE1L2: view

Variants for DNASE1L2 Gene

Sequence variations from dbSNP and Humsavar for DNASE1L2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1056834 -- 2,235,260(+) CACCA(C/G)GCTAG nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-3-prime
rs1056869 -- 2,235,620(+) GGACT(C/T)TGAGC nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs111804441 -- 2,237,294(+) TGTTC(C/G/T)TGTAC reference, missense
rs112938340 -- 2,234,790(+) TGGGC(A/C/G/T)GGTGG intron-variant, upstream-variant-2KB
rs113436938 -- 2,238,377(+) TCAGC(A/G)ACCAC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DNASE1L2 Gene

Variant ID Type Subtype PubMed ID
dgv4859n54 CNV loss 21841781
dgv4861n54 CNV loss 21841781
dgv4863n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
esv2673834 CNV deletion 23128226
esv3637631 CNV loss 21293372
nsv1052260 CNV gain 25217958
nsv457351 CNV loss 19166990
nsv471072 CNV loss 18288195
nsv571200 CNV loss 21841781
nsv952902 CNV deletion 24416366

Variation tolerance for DNASE1L2 Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNASE1L2 Gene

Human Gene Mutation Database (HGMD)
DNASE1L2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNASE1L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNASE1L2 Gene

Disorders for DNASE1L2 Gene

Relevant External Links for DNASE1L2

Human Genome Epidemiology (HuGE) Navigator
DNASE1L2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNASE1L2

No disorders were found for DNASE1L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNASE1L2 Gene

Publications for DNASE1L2 Gene

  1. DNase1L2 degrades nuclear DNA during corneocyte formation. (PMID: 16902420) Fischer H. … Tschachler E. (J. Invest. Dermatol. 2007) 3 4 22 64
  2. Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I. (PMID: 9205125) Rodriguez A.M. … Schneider M.C. (Genomics 1997) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Characterization of the human DNAS1L2 gene and the molecular mechanism for its transcriptional activation induced by inflammatory cytokines. (PMID: 15203207) Shiokawa D. … Tanuma S.I. (Genomics 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for DNASE1L2 Gene

Sources for DNASE1L2 Gene

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