DNASE1L2 Gene
protein-coding GIFtS: 53
GCID: GC16P002285
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|
deoxyribonuclease I-like 2
| |
Aliases
for DNASE1L2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Deoxyribonuclease I-Like 21 2 3 | | Deoxyribonuclease-1-Like 22 | | DNAS1L21 2 3 | | DHP13 | | DNase I Homolog Protein DHP12 3 | | EC 3.1.21.-3 | | DNase I-Like 22 3 | | EC 3.1.21.18 |
Export aliases for DNASE1L2 gene to outside databasesPrevious GC identifers: GC16M002497 GC16P002311 GC16P002226 GC16P002286 GC16P002212 |
Summaries
for DNASE1L2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for DNASE1L2
|
Genomic Views
for DNASE1L2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DNASE1L2 gene promoter:
ER-alpha AML1a p53 Lmo2 Tal-1beta Meis-1b E47 Meis-1a Pax-4a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DNASE1L2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNASE1L2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3DNASE1L2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P002285: view genomic region
(about GC identifiers)
Start:
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2,285,817 bp from pter |
End:
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2,288,712 bp from pter |
Size:
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2,896 bases |
Orientation:
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plus strand |
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Proteins
for DNASE1L2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DNSL2_HUMAN, Q92874 (See
protein sequence)Recommended Name: Deoxyribonuclease-1-like 2 precursor Size: 299 amino acids; 32853 Da
Subcellular location: Secreted (Potential)Explore the universe of human proteins at neXtProt for DNASE1L2: NX_Q92874
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92874
4/5 DME Specific Peptides for DNASE1L2 (Q92874) (see all 5)
DNASE1L2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001365.1
ENSEMBL proteins: ENSP00000454562 ENSP00000316938 ENSP00000455358 ENSP00000371874 ENSP00000455478 ENSP00000445343
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
DNASE1L2 for ontologies About GeneDecksing
DNASE1L2 Antibody Products:
Assay Products for DNASE1L2: |
Protein
Domains /
Families
for DNASE1L2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DNASE1L2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q92874ProtoNet protein and cluster: Q92874 1 Blocks protein family: IPB008185 Deoxyribonuclease I
UniProtKB/Swiss-Prot: DNSL2_HUMAN, Q92874Similarity: Belongs to the DNase I family |
Function
for DNASE1L2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for DNASE1L2:DNase I-like endonuclease 2,expressed in brain
Enzyme Numbers (IUBMB): EC 3.1.21.-1 EC 3.1.21.12
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNASE1L2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNASE1L2 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
DNASE1L2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for DNASE1L2: Dnase1l2tm1Eckh Dnase1l2tm1(KOMP)Wtsi
9 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Dnase1l2):
DNASE1L2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for DNASE1L2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNASE1L2
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for DNASE1L2 (Q928741, 2, 3 ENSP000003169384) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
DNASE1L2 for ontologies About GeneDecksing
|
Drugs & Compounds
for DNASE1L2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DNASE1L2
Search CenterWatch for drugs/clinical trials and news about DNASE1L2 / DNSL2
|
Transcripts
for DNASE1L2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DNASE1L2 gene: NM_001374.2 Unigene Cluster for DNASE1L2: Deoxyribonuclease I-like 2 Hs.103503 [show with all ESTs]Unigene Representative Sequence: AK0980286 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000564065(uc002cpn.3 uc002cpo.3) ENST00000320700(uc002cpp.3 uc002cpq.3)
ENST00000567494 ENST00000382437 ENST00000569184 ENST00000541838
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNASE1L2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNASE1L2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DNASE1L2 (NM_001374) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DNASE1L2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNASE1L2 |
Additional cDNA sequence: AK098028.1 AY298957.1 BC035205.1 BC063710.1 U62647.1 5 DOTS entries: DT.100019786 DT.120702799 DT.100778478 DT.91664836 DT.91650498 24/153 AceView cDNA sequences (see all 153): BU539326 BM676507 Z38690 AY298957 BM713890 BX284025 BU501086 BI223566 BC014068 CA405900 AW515664 BM796095 BC080524 CA422408 BC035205 BC063710 BU957083 CA488104 AI675620 AK098028 BX283985 AI420452 NM_001374 BM686240
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for DNASE1L2 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b |
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| SP1: | | | | | | | | | | | | | | | |
| SP2: | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for DNASE1L2
|
Expression
for DNASE1L2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DNASE1L2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGGGTGCAG
About this image
See DNASE1L2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DNASE1L2
SOURCE GeneReport for Unigene cluster: Hs.103503
UniProtKB/Swiss-Prot: DNSL2_HUMAN, Q92874Tissue specificity: Brain
SABiosciences Custom PCR Arrays for DNASE1L2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNASE1L2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DNASE1L2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNASE1L2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNASE1L2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNASE1L2 |
Orthologs
for DNASE1L2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for DNASE1L2 gene from 3/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
DNASE1L21 |
deoxyribonuclease I-like 2 |
73.26(n)
69.2(a) |
|
427682 XM_425256.2 XP_425256.2 |
lizard
(Anolis carolinensis) |
Reptilia |
DNASE1L26 |
-- |
60(a) |
1 ↔ 1 |
GL343691.1(77827-97090) |
zebrafish
(Danio rerio) |
Actinopterygii |
dnase16 |
deoxyribonuclease I |
50(a) |
1 → many |
3(27930094-27935576) |
ENSEMBL Gene Tree for DNASE1L2 (if available)
TreeFam Gene Tree for DNASE1L2 (if available) |
Paralogs
for DNASE1L2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DNASE1L2 gene
- DNASE1L32 DNASE12 DNASE1L12
3 SIMAP similar genes for DNASE1L2 using alignment to 4 protein entries: DNSL2_HUMAN (see all proteins):DNASE1 DNASE1L3 DNASE1L1
DNASE1L2 for paralogs About GeneDecksing
|
Genomic Variants
for DNASE1L2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DNASE1L2 (2285817 - 2288712 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for DNASE1L2
2 CNVs: 30002 5329 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for DNASE1L2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DNASE1L2 for disorders About GeneDecksing
OMIM gene information: 602622
OMIM disorders: --
2  diseases for DNASE1L2: About MalaCardspolycystic kidney disease kidney disease
Human Genome Epidemiology (HuGE) Navigator: DNASE1L2 (1 document)
Export disorders for DNASE1L2 gene to outside databases
|
Publications
for DNASE1L2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DNASE1L2 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with DNASE1L2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I. (PubMed id 9205125)1, 2, 3 Rodriguez A.M....Schneider M.C. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The gene for autosomal dominant polycystic kidney disease lies in a 750-kb CpG-rich region. (PubMed id 1577479)1, 3 Germino G.G....Reeders S.T. (1992)
- DNase1L2 degrades nuclear DNA during corneocyte formation. (PubMed id 16902420)1, 9 Fischer H....Tschachler E. (2007)
- Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis. (PubMed id 11141064)1, 9 Shiokawa D. and Tanuma S. (2001)
- Global analysis of single nucleotide polymorphisms in the exons of human deoxyribonuclease I-like 1 and 2 genes. (PubMed id 20967767)1 Fujihara J....Takeshita H. (2010)
- Genetic and expression analysis of all non-synonymous single nucleotide polymorphisms in the human deoxyribonuclease I-like 1 and 2 genes. (PubMed id 20503202)1 Ueki M....Yasuda T. (2010)
- Terminal differentiation of nail matrix keratinocytes involves up-regulation of DNase1L2 but is independent of caspase-14 expression. (PubMed id 17490414)1 Jager K....Eckhart L. (2007)
- Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)
- Characterization of the human DNAS1L2 gene and the molecular mechanism for its transcriptional activation induced by inflammatory cytokines. (PubMed id 15203207)1 Shiokawa D.... Tanuma S. (2004)
|
External Searches for DNASE1L2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DNASE1L2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DNASE1L2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DNASE1L2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DNASE1L2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DNASE1L2 gene:
Search GeneIP for patents involving DNASE1L2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DNASE1L2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DNASE1L2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNASE1L2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNASE1L2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNASE1L2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNASE1L2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNASE1L2 |
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 | | | DNASE1L2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNASE1L2 |
|  |  |  | | | | Search ThermoFisher Antibodies for DNASE1L2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNASE1L2 |
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