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DNASE1L2 Gene

protein-coding   GIFtS: 53
GCID: GC16P002285

Deoxyribonuclease I-Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Deoxyribonuclease I-Like 21 2 3     Deoxyribonuclease-1-Like 22
DNAS1L22 3     DHP13
DNase I Homolog Protein DHP12 3     EC 3.1.21.-3
DNase I-Like 22 3     EC 3.1.21.18

External Ids:    HGNC: 29581   Entrez Gene: 17752   Ensembl: ENSG000001679687   OMIM: 6026225   UniProtKB: Q928743   

Export aliases for DNASE1L2 gene to outside databases

Previous GC identifers: GC16M002497 GC16P002311 GC16P002226 GC16P002286 GC16P002212


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DNASE1L2 Gene:
DNASE1L2 (deoxyribonuclease I-like 2) is a protein-coding gene. Diseases associated with DNASE1L2 include polycystic kidney disease, and kidney disease. GO annotations related to this gene include endodeoxyribonuclease activity, producing 5'-phosphomonoesters and calcium ion binding. An important paralog of this gene is DNASE1L3.

UniProtKB/Swiss-Prot: DNSL2_HUMAN, Q92874
Function: Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during
corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into
the extracellular environment by damaged epidermal cells

Gene Wiki entry for DNASE1L2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNASE1L2 gene promoter:
         ER-alpha   AML1a   p53   Lmo2   Tal-1beta   Meis-1b   E47   Meis-1a   Pax-4a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DNASE1L2 promoter sequence
   Search Chromatin IP Primers for DNASE1L2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNASE1L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

DNASE1L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNASE1L2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P002285:  view genomic region     (about GC identifiers)

Start:
2,285,817 bp from pter      End:
2,288,712 bp from pter
Size:
2,896 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DNSL2_HUMAN, Q92874 (See protein sequence)
Recommended Name: Deoxyribonuclease-1-like 2 precursor  
Size: 299 amino acids; 32853 Da
Cofactor: Divalent metal cations. Seems to require both calcium and magnesium
Secondary accessions: E9PBY4 Q6JVM2 Q6JVM3
Alternative splicing: 2 isoforms:  Q92874-1   Q92874-2   (Specifically expressed in peripheral blood leukocytes)

Explore the universe of human proteins at neXtProt for DNASE1L2: NX_Q92874

Explore proteomics data for DNASE1L2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DNASE1L2 (Q92874) (see all 5)
     CAYDRIV  SDHFPVE  GDFNADC  FSREPFVV 


    See DNASE1L2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001365.1  
    ENSEMBL proteins: 
     ENSP00000454562   ENSP00000316938   ENSP00000455358   ENSP00000371874   ENSP00000455478  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR018057 Deoxyribonuclease-1_AS
     IPR016202 DNase_I
     IPR005135 Endo/exonuclease/phosphatase

    Graphical View of Domain Structure for InterPro Entry Q92874

    ProtoNet protein and cluster: Q92874

    1 Blocks protein domain: IPB008185 Deoxyribonuclease I

    UniProtKB/Swiss-Prot: DNSL2_HUMAN, Q92874
    Similarity: Belongs to the DNase I family


    DNASE1L2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DNSL2_HUMAN, Q92874
    Function: Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during
    corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into
    the extracellular environment by damaged epidermal cells
    Induction: Up-regulated by inflammatory cytokines

         Genatlas biochemistry entry for DNASE1L2:
    DNase I-like endonuclease 2,expressed in brain

         Enzyme Numbers (IUBMB): EC 3.1.21.-1 EC 3.1.21.12

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS9205125
    GO:0004536deoxyribonuclease activity TAS9205125
    GO:0005509calcium ion binding TAS9205125
    GO:0016888endodeoxyribonuclease activity, producing 5'-phosphomonoesters IEA--
         
    DNASE1L2 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dnase1l2):
     behavior/neurological  cellular  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  skeleton 

    DNASE1L2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DNASE1L2: Dnase1l2tm1Eckh Dnase1l2tm1(KOMP)Wtsi

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNASE1L2
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    2 qRT-PCR Assays for microRNAs that regulate DNASE1L2:
    hsa-miR-1184 hsa-miR-1205
    SwitchGear 3'UTR luciferase reporter plasmidDNASE1L2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNASE1L2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DNSL2_HUMAN, Q92874: Cytoplasm. Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005737cytoplasm IEA--

    DNASE1L2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DNASE1L2
    Interactions:

        Search GeneGlobe Interaction Network for DNASE1L2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for DNASE1L2 (Q928741, 2, 3 ENSP000003169384) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005191, 2, 3, ENSP000003614234EBI-1751995,EBI-375543 MINT-8110251 I2D: score=3 STRING: ENSP00000361423
    FYNP062411, 2, 3, ENSP000003576564EBI-1751995,EBI-515315 MINT-8111139 I2D: score=3 STRING: ENSP00000357656
    AICDAENSP000002293354STRING: ENSP00000229335
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006259DNA metabolic process TAS9205125
    GO:0006308DNA catabolic process ----

    DNASE1L2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNASE1L2 (DNSL2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DNASE1L2 gene: 
    NM_001374.2  

    Unigene Cluster for DNASE1L2:

    Deoxyribonuclease I-like 2
    Hs.103503  [show with all ESTs]
    Unigene Representative Sequence: AK098028
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000564065(uc002cpn.3 uc002cpo.3) ENST00000320700(uc002cpp.3 uc002cpq.3)
    ENST00000567494 ENST00000382437 ENST00000569184
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate DNASE1L2:
    hsa-miR-1184 hsa-miR-1205
    SwitchGear 3'UTR luciferase reporter plasmidDNASE1L2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat DNASE1L2
      QuantiFast Probe-based Assays in human, mouse, rat DNASE1L2

    Additional mRNA sequence: 

    AK098028.1 AY298957.1 BC035205.1 BC063710.1 U62647.1 

    5 DOTS entries:

    DT.100019786  DT.120702799  DT.100778478  DT.91664836  DT.91650498 

    Selected AceView cDNA sequences (see all 153):

    BC063710 BI223566 BM676507 BX284025 CA405900 BX283985 BU501086 BU539326 
    AY298957 BM796095 BU957083 BC014068 AI675620 BC035205 NM_001374 AW515664 
    AI420452 CA488104 BM713890 Z38690 BC080524 CA422408 AK098028 BG753231 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for DNASE1L2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
    SP1:                                          
    SP2:        -                                 


    ECgene alternative splicing isoforms for DNASE1L2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNASE1L2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGGGTGCAG
    DNASE1L2 Expression
    About this image


    DNASE1L2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Epithelial Cells
             Fetal Matrix Cells Hair Follicle
     
     Epidermis (Integumentary System)    fully expand to see all 2 entries
             Granular Keratinocytes Stratified Epidermis
     
     Hair (Integumentary System)
             Fetal Matrix Cells Hair Follicle
     
     Prostate (Endocrine System)
    DNASE1L2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNASE1L2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.103503

    UniProtKB/Swiss-Prot: DNSL2_HUMAN, Q92874
    Tissue specificity: Preferentially expressed in the skin and up-regulated during keratinocytes differentiation.
    Highly abundant (at protein level) in the stratum granulosum

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DNASE1L2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnase1l21 , 5 deoxyribonuclease 1-like 21, 5 79.5(n)1
    83.09(a)1
      17 (12.39 cM)5
    667051  NM_025718.31  NP_079994.21 
     244400815 
    chicken
    (Gallus gallus)
    Aves --
    DNASE16
    Gallus gallus deoxyribonuclease I (DNASE1), mRNA.
    64(a)
    57(a)
    1 ↔ many
    1 ↔ many
    14(12310668-12313707)
    14(12316280-12320315)
    lizard
    (Anolis carolinensis)
    Reptilia DNASE1L26
    deoxyribonuclease I-like 2
    52(a)
    1 ↔ 1
    GL343691.1(76535-108399)
    zebrafish
    (Danio rerio)
    Actinopterygii dnase16
    deoxyribonuclease I
    49(a)
    1 → many
    3(27930094-27935576) ENSDARG00000012539


    ENSEMBL Gene Tree for DNASE1L2 (if available)
    TreeFam Gene Tree for DNASE1L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNASE1L2 gene
    DNASE1L32  DNASE12  DNASE1L12  
    3 SIMAP similar genes for DNASE1L2 using alignment to 2 protein entries:     DNSL2_HUMAN (see all proteins):
    DNASE1    DNASE1L1    DNASE1L3

    DNASE1L2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNASE1L2 (see all 118)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1495374161,2
    --2286261(+) CGGTTC/TTGGGA 1 -- us2k10--------
    rs1836905751,2
    --2286322(+) TGGGGA/GTCTCC 1 -- us2k10--------
    rs1883629931,2
    --2286325(+) GGGTCC/TCCATG 1 -- us2k10--------
    rs1926522631,2
    --2286394(+) GCAGCC/TCGGCC 1 -- us2k10--------
    rs1848450101,2
    --2286490(+) ACACGC/TCCGCA 1 -- ut510--------
    rs1463975271,2
    C--2286567(+) GTGAG-/TCTC  
            
    TCGGC
    1 -- int10--------
    rs31141301,2
    C,F,A--2286575(-) GGGCAG/ACCGAG 1 -- int18Minor allele frequency- A:0.48NA WA CSA 131
    rs1869071341,2
    C--2286579(+) GCTGCC/TCTGAG 1 -- int10--------
    rs1915175951,2
    C--2286876(+) GACCGA/CCGCGC 2 D A mis10--------
    rs2000322821,2
    C--2286970(+) GGGCCC/TGGGCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for DNASE1L2 (2285817 - 2288712 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DNASE1L2 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673834CNV Deletion23128226
    esv2422427CNV Duplication17116639
    dgv2545n71CNV Loss21882294
    dgv2563n71CNV Loss21882294
    dgv2546n71CNV Loss21882294
    nsv457351CNV Loss19166990
    dgv2557n71CNV Loss21882294
    nsv905139CNV Loss21882294
    dgv2540n71CNV Loss21882294
    dgv2550n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602622    OMIM disorders: --

    2 diseases for DNASE1L2:    
    About MalaCards
    polycystic kidney disease    kidney disease


    DNASE1L2 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: DNASE1L2 (1 document)

    Export disorders for DNASE1L2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNASE1L2 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with DNASE1L2)
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    1. Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I. (PubMed id 9205125)1, 2, 3 Rodriguez A.M....Schneider M.C. (Genomics 1997)
    2. DNase1L2 degrades nuclear DNA during corneocyte formation. (PubMed id 16902420)1, 2, 9 Fischer H....Tschachler E. (J. Invest. Dermatol. 2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Characterization of the human DNAS1L2 gene and the molecular mechanism for its transcriptional activation induced by inflammatory cytokines. (PubMed id 15203207)1, 2 Shiokawa D.... Tanuma S.I. (Genomics 2004)
    6. The gene for autosomal dominant polycystic kidney disease lies in a 750-kb CpG-rich region. (PubMed id 1577479)1, 3 Germino G.G....Reeders S.T. (Genomics 1992)
    7. Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis. (PubMed id 11141064)1, 9 Shiokawa D. and Tanuma S. (Biochemistry 2001)
    8. Five non-synonymous SNPs in the gene encoding human deoxyribonuclease I-like 2 implicated in terminal differentiation of keratinocytes reduce or abolish its activity. (PubMed id 23161465)1 Ueki M....Yasuda T. (Electrophoresis 2013)
    9. Global analysis of single nucleotide polymorphisms in the exons of human deoxyribonuclease I-like 1 and 2 genes. (PubMed id 20967767)1 Fujihara J....Takeshita H. (Electrophoresis 2010)
    10. Genetic and expression analysis of all non-synonymous single nucleotide polymorphisms in the human deoxyribonuclease I-like 1 and 2 genes. (PubMed id 20503202)1 Ueki M....Yasuda T. (Electrophoresis 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1775 HGNC: 2958 AceView: DNASE1L2andE4F1 Ensembl:ENSG00000167968 euGenes: HUgn1775
    ECgene: DNASE1L2 H-InvDB: DNASE1L2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DNASE1L2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNASE1L2 gene:
    Search GeneIP for patents involving DNASE1L2

    GeneCards and IP:
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