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DNASE1L1 Gene

protein-coding   GIFtS: 53
GCID: GC0XM153629

Deoxyribonuclease I-Like 1


(Previous symbol: DNL1L)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Deoxyribonuclease I-Like 11 2 3     G4.82
DNL1L1 2 3 5     Deoxyribonuclease-1-Like 12
DNase X1 2 3     DNase I-Like, Muscle-Specific2
DNAS1L12 3     EC 3.1.21.-3
XIB2 3     Muscle-Specific DNase I-Like3
DNase I-Like 12 3     EC 3.1.218
DNASEX2     EC 3.1.21.18

External Ids:    HGNC: 29571   Entrez Gene: 17742   Ensembl: ENSG000000135637   OMIM: 3000815   UniProtKB: P491843   

Export aliases for DNASE1L1 gene to outside databases

Previous GC identifers: GC0XM147693 GC0XM150010 GC0XM151215 GC0XM152098 GC0XM153150 GC0XM153282 GC0XM142206


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNASE1L1 Gene:
This gene encodes a member of the deoxyribonuclease family and the protein shows high sequence similarity to
lysosomal DNase I. Alternate transcriptional splice variants, encoding the same protein, have been characterized.
(provided by RefSeq, Jul 2008)

GeneCards Summary for DNASE1L1 Gene:
DNASE1L1 (deoxyribonuclease I-like 1) is a protein-coding gene. Diseases associated with DNASE1L1 include keratomalacia, and xerophthalmia. GO annotations related to this gene include endodeoxyribonuclease activity, producing 5'-phosphomonoesters and deoxyribonuclease activity. An important paralog of this gene is DNASE1L3.

Gene Wiki entry for DNASE1L1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_011681.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNASE1L1 gene promoter:
         AP-1   ATF-2   Nkx2-5   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): DNASE1L1 promoter sequence
   Search Chromatin IP Primers for DNASE1L1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNASE1L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

DNASE1L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNASE1L1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM153629:  view genomic region     (about GC identifiers)

Start:
153,629,579 bp from pter      End:
153,640,449 bp from pter
Size:
10,871 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DNSL1_HUMAN, P49184 (See protein sequence)
Recommended Name: Deoxyribonuclease-1-like 1 precursor  
Size: 302 amino acids; 33893 Da
Secondary accessions: D3DWW7 Q5HY41

Explore the universe of human proteins at neXtProt for DNASE1L1: NX_P49184

Explore proteomics data for DNASE1L1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn261
  • Selected DME Specific Peptides for DNASE1L1 (P49184) (see all 7)
     GDFNADC  FAREPFV  VLQEVVDS  SDHYPVEV 


    See DNASE1L1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001009932.1  NP_001009933.1  NP_001009934.1  NP_006721.1  

    ENSEMBL proteins: 
     ENSP00000358822   ENSP00000358823   ENSP00000014935   ENSP00000309168   ENSP00000395591  
     ENSP00000393346   ENSP00000416881   ENSP00000393000   ENSP00000410281   ENSP00000358824  
     ENSP00000377255  

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    Novus Biologicals DNASE1L1 Protein
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    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

    DNASE1L1 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR018057 Deoxyribonuclease-1_AS
     IPR016202 DNase_I
     IPR005135 Endo/exonuclease/phosphatase

    Graphical View of Domain Structure for InterPro Entry P49184

    ProtoNet protein and cluster: P49184

    1 Blocks protein domain: IPB008185 Deoxyribonuclease I

    UniProtKB/Swiss-Prot: DNSL1_HUMAN, P49184
    Similarity: Belongs to the DNase I family


    DNASE1L1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for DNASE1L1:
    DNase I-like endonuclease X-linked,35kDa,cardiac and muscle specific

         Enzyme Numbers (IUBMB): EC 3.1.212 EC 3.1.21.-1 EC 3.1.21.12

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS9205125
    GO:0004536deoxyribonuclease activity TAS9205125
    GO:0016888endodeoxyribonuclease activity, producing 5'-phosphomonoesters IEA--
         
    DNASE1L1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DNASE1L1:
     Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dnase1l1):
     behavior/neurological 

    DNASE1L1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dnase1l1tm1Dkfz for DNASE1L1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNASE1L1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DNASE1L1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DNASE1L1

    miRNA
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    miRTarBase miRNAs that target DNASE1L1:
    hsa-mir-484 (MIRT042294)

    Block miRNA regulation of human, mouse, rat DNASE1L1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DNASE1L1:
    hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmidDNASE1L1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat DNASE1L1

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    GenScript: all cDNA clones in your preferred vector (see all 4): DNASE1L1 (NM_001009933)
    Sino Biological Human cDNA Clone for DNASE1L1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNASE1L1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNASE1L1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNASE1L1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DNSL1_HUMAN, P49184: Endoplasmic reticulum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--

    DNASE1L1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DNASE1L1
    Interactions:

        Search GeneGlobe Interaction Network for DNASE1L1

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006259DNA metabolic process TAS9205125
    GO:0006308DNA catabolic process ----

    DNASE1L1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNASE1L1 (DNSL1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DNASE1L1 gene (4 alternative transcripts): 
    NM_001009932.1  NM_001009933.1  NM_001009934.1  NM_006730.2  

    Unigene Cluster for DNASE1L1:

    Deoxyribonuclease I-like 1
    Hs.401929  [show with all ESTs]
    Unigene Representative Sequence: NM_006730
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369807 ENST00000369808(uc004fkt.1) ENST00000014935 ENST00000309585
    ENST00000497242 ENST00000447892 ENST00000451865 ENST00000412184 ENST00000424626
    ENST00000432135 ENST00000369809(uc004fks.1 uc004fku.1 uc004fkv.1)
    ENST00000393638(uc004fkw.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DNASE1L1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DNASE1L1:
    hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmidDNASE1L1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 4): DNASE1L1 (NM_001009933)
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    Primer
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    OriGene qPCR primer pairs and template standards for DNASE1L1
    OriGene qSTAR qPCR primer pairs in human, mouse for DNASE1L1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNASE1L1
      QuantiTect SYBR Green Assays in human, mouse, rat DNASE1L1
      QuantiFast Probe-based Assays in human, mouse, rat DNASE1L1

    Additional mRNA sequence: 

    BC001561.1 BC028092.1 BT019990.1 L40823.1 U06846.1 X90392.1 X90393.1 

    15 DOTS entries:

    DT.75146295  DT.92071261  DT.100781541  DT.215496  DT.101977215  DT.95177353  DT.100781536  DT.100781539 
    DT.121293791  DT.121294335  DT.97870113  DT.121294193  DT.217832  DT.87016116  DT.95314568 

    Selected AceView cDNA sequences (see all 164):

    BM716750 BU075643 F18999 AA317506 AI718712 BU075839 BU153110 BM875290 
    BF589060 BU956786 AL079680 CA424854 X90393 BE675489 BM674382 X87196 
    U06846 CD513465 BG576512 BQ437463 BM685678 BM673333 BE873036 BX402629 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNASE1L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DNASE1L1 Expression
    About this image

    DNASE1L1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNASE1L1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.401929

    UniProtKB/Swiss-Prot: DNSL1_HUMAN, P49184
    Tissue specificity: Highest levels in skeletal and cardiac muscles. Detectable in all other tissues tested except
    brain

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNASE1L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DNASE1L1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnase1l11 , 5 deoxyribonuclease 1-like 11, 5 75.67(n)1
    71.9(a)1
      X (37.94 cM)5
    695371  NM_001172154.11  NP_001165625.11 
     742732175 
    lizard
    (Anolis carolinensis)
    Reptilia DNASE1L16
    deoxyribonuclease I-like 1
    47(a)
    1 ↔ 1
    2(86423253-86454523)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004909141 deoxyribonuclease gamma-like 54.99(n)
    45.91(a)
      100490914  XM_004919644.1  XP_004919701.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dnase1l36
    deoxyribonuclease I-like 3
    40(a)
    1 ↔ 1
    23(19990137-20000538) ENSDARG00000005464


    ENSEMBL Gene Tree for DNASE1L1 (if available)
    TreeFam Gene Tree for DNASE1L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNASE1L1 gene
    DNASE1L32  DNASE1L22  DNASE12  
    3 SIMAP similar genes for DNASE1L1 using alignment to 6 protein entries:     DNSL1_HUMAN (see all proteins):
    DNASE1L3    DNASE1    DNASE1L2

    DNASE1L1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNASE1L1 (see all 259)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs120127471,2
    C,A,H--153497441(+) CCCCAG/ATCGTG 4 -- ds50012Minor allele frequency- A:0.14WA NS 148
    rs1434243441,2
    F--153497466(+) TGGCGG/AGCCCT 4 -- ds50011Minor allele frequency- A:0.00NA 2820
    rs2003710971,2
    --153497477(+) GCACTC/TATGAG 4 -- ds50010--------
    rs1995384311,2
    --153497500(+) GCTGCC/TCCCCT 4 -- ds50010--------
    rs115471571,2
    C--153497523(+) CAATAA/GATTCT 4 -- ds50012Minor allele frequency- G:0.00NA 4
    rs1894336101,2
    --153497580(+) GGAACA/TTCCTC 4 -- ds50010--------
    rs1927566741,2
    --153497646(+) CTGCTC/TATGAG 4 -- ds50010--------
    rs603077231,2
    C,F--153497848(+) ACATGC/TGGACC 4 -- ds50011Minor allele frequency- T:0.01NS 150
    rs1848180611,2
    --153497849(+) CATGCA/GGACCA 4 -- ds50010--------
    rs1900838361,2
    --153497872(+) GGGCTA/GGAGGC 4 -- ut310--------

    HapMap Linkage Disequilibrium report for DNASE1L1 (153629579 - 153640449 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for DNASE1L1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664900CNV Deletion23128226
    esv2677035CNV Deletion23128226
    nsv519042CNV Gain19592680
    esv33199CNV Gain+Loss17666407
    esv33784CNV Gain+Loss17666407
    nsv7468OTHER Inversion18451855

    Locus Specific Mutation Databases (LSDB): DNASE1L1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNASE1L1
    DNA2.0 Custom Variant and Variant Library Synthesis for DNASE1L1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300081    OMIM disorders: --

    7 diseases for DNASE1L1:    
    About MalaCards
    keratomalacia    xerophthalmia    glycogen storage disease ii    barth syndrome
    glycogen storage disease    night blindness    blindness

    4 diseases from the University of Copenhagen DISEASES database for DNASE1L1:
    Xerophthalmia     Keratomalacia     Glycogen storage disease II     Barth syndrome

    DNASE1L1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DNASE1L1
    Human Genome Epidemiology (HuGE) Navigator: DNASE1L1 (4 documents)

    Export disorders for DNASE1L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNASE1L1 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with DNASE1L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A muscle-specific DNase I-like gene in human Xq28. (PubMed id 8541839)1, 2, 3, 9 Parrish J.E....Nelson D.L. (Hum. Mol. Genet. 1995)
    2. Cloning of a gene encoding a DNase I-like endonuclease in the human Xq28 region. (PubMed id 8654957)1, 2, 3 Pergolizzi R....Biunno I. (Gene 1996)
    3. Physical and biochemical properties of mammalian DNase X proteins: non-AUG translation initiation of porcine and bovine mRNAs for DNase X. (PubMed id 16107205)1, 2, 9 Shiokawa D.... Tanuma S. (Biochem. J. 2005)
    4. Isolation, differential splicing and protein expression of a DNase on the human X chromosome. (PubMed id 17180083)1, 2, 9 Coy J.F.... Zentgraf H. (Cell Death Differ. 1996)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. (PubMed id 8733135)1, 2 Chen E.Y....D'Urso M. (Hum. Mol. Genet. 1996)
    9. Molecular characterization of a novel endonuclease (Xib) and possible involvement in lysosomal glycogen storage disorders. (PubMed id 10409440)1, 9 Malferrari G....Biunno I. (Exp. Mol. Pathol. 1999)
    10. A biomarker based detection and characterization of carcinomas exploiting two fundamental biophysical mechanisms in mammalian cells. (PubMed id 24304513)1 Grimm M....Coy J.F. (BMC Cancer 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1774 HGNC: 2957 AceView: DNASE1L1 Ensembl:ENSG00000013563 euGenes: HUgn1774
    ECgene: DNASE1L1 H-InvDB: DNASE1L1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DNASE1L1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNASE1L1 gene:
    Search GeneIP for patents involving DNASE1L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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