Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DNASE1 Gene

protein-coding GIFtS: 62
GCID: GC16P003663

deoxyribonuclease I

(Previous symbol: DNL1)

Explore 64 diseases affiliated with
DNASE1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Deoxyribonuclease I¹ ² ³		Deoxyribonuclease-1¹
DNL1¹ ² ³ ⁵		DNase I, Lysosomal²
DRNI² ³		Human Urine Deoxyribonuclease I²
Dornase Alfa² ³		DNase I³
EC 3.1.21.1³ ⁸

External Ids:	HGNC: 2956¹	Entrez Gene: 1773²	Ensembl: ENSG00000213918⁷	OMIM: 125505⁵	UniProtKB: P24855³

Export aliases for DNASE1 gene to outside databases

Previous GC identifers: GC16P003733 GC16P003704 GC16P003630 GC16P003692

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DNASE1:

This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope

and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been

characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this

gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this

protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and

reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been

thoroughly characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DNAS1_HUMAN, P24855

Function: Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and

blocks actin polymerization (By similarity)

Gene Wiki entry for DNASE1 (Deoxyribonuclease I)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DNASE1 gene promoter:
GR AML1a GR-beta Tal-1beta E47 CP2 GR-alpha MRF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): DNASE1 promoter sequence

Search SABiosciences Chromatin IP Primers for DNASE1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNASE1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

DNASE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNASE1 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P003663: view genomic region (about GC identifiers)

Start:	3,661,729 bp from pter	End:	3,730,144 bp from pter
Size:	68,416 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DNAS1_HUMAN, P24855 (See protein sequence)

Recommended Name: Deoxyribonuclease-1 precursor

Size: 282 amino acids; 31434 Da

Cofactor: Divalent cations. Prefers calcium or magnesium

Subcellular location: Secreted. Nucleus envelope. Note=Secretory protein, stored in zymogen granules and found in the

nuclear envelope

1 PDB 3D structure from and Proteopedia for DNASE1:

4AWN (3D)

Secondary accessions: Q14UU9 Q14UV0

Explore the universe of human proteins at neXtProt for DNASE1: NX_P24855

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P24855

4/9 DME Specific Peptides for DNASE1 (P24855) (see all 9)

FAIVPLH

YKERYLF

CAYDRIV

AVGKLLD

DNASE1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005214.2

ENSEMBL proteins:

ENSP00000458467 ENSP00000461745 ENSP00000385905 ENSP00000246949 ENSP00000459850

ENSP00000461725 ENSP00000458959 ENSP00000461527 ENSP00000459507 ENSP00000461129

ENSP00000461153 ENSP00000416699

Human Recombinant Protein Products for DNASE1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: DNASE1 OriGene Custom Protein Services for DNASE1
	GenScript Custom Purified and Recombinant Proteins Services for DNASE1
	Novus Biologicals DNASE1 Proteins Novus Biologicals DNASE1 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for DNASE1
	Uscn Proteins for DNASE1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005635	nuclear envelope	IEA	--

DNASE1 for ontologies About GeneDecksing

DNASE1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of DNASE1
	Browse R&D Systems for Antibodies
	OriGene Antibodies: DNASE1 OriGene Custom Antibody Services for DNASE1
	GenScript Custom Superior Antibodies Services for DNASE1
	Novus Biologicals DNASE1 Antibodies
	Abcam antibodies for DNASE1
	Uscn Antibodies for DNASE1
	ThermoFisher Antibodies for DNASE1

Assay Products for DNASE1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DNASE1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DNASE1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DNASE1 for domains About GeneDecksing

4 InterPro domains/families:

IPR016202 DNase_I-like

IPR005135 Endo/exonuclease/phosphatase

IPR008185 DNase_I_euk

IPR018057 Deoxyribonuclease-1_AS

Graphical View of Domain Structure for InterPro Entry P24855

ProtoNet protein and cluster: P24855

1 Blocks protein family: IPB008185 Deoxyribonuclease I

UniProtKB/Swiss-Prot: DNAS1_HUMAN, P24855

Similarity: Belongs to the DNase I family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DNAS1_HUMAN, P24855

Function: Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and

blocks actin polymerization (By similarity)

Catalytic activity: Endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end-products

Genatlas biochemistry entry for DNASE1:

deoxyribonuclease I,involved in nuclear DNA degradation during apoptosis

Enzyme Number (IUBMB): EC 3.1.21.1¹ ²

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0004530	deoxyribonuclease I activity	IEA	--
GO:0004536	deoxyribonuclease activity	--	--
GO:0005515	protein binding	IPI	12849983
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	--	--

DNASE1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for DNASE1:

Proliferating cells

6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dnase1):

cellular	hematopoietic system	homeostasis/metabolism	immune system	mortality/aging
renal/urinary system

DNASE1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Dnase1^tm1Tmo for DNASE1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DNASE1

miRNA Products:		OriGene 3'-UTR Clone: DNASE1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DNASE1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DNASE1
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNASE1 (see all 7) OriGene shRNA RFP: DNASE1 OriGene siRNA: DNASE1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNASE1
		Sirion Biotech Custom design and validation of potent shRNA sequences against DNASE1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for DNASE1
			Sirion Biotech Customized adenovirus for overexpression of DNASE1 Sirion Biotech Customized adenovirus for potent knockdown of DNASE1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNASE1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNASE1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DNASE1 (NM_005223)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNASE1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNASE1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DNASE1
		Search LifeMap BioReagents cell lines for DNASE1
		Sirion Biotech Customized stable knockdown cell line services for DNASE1 Sirion Biotech Customized inducible knockdown cell line services for DNASE1 Sirion Biotech Customized stable overexpressing cell line services for DNASE1 Sirion Biotech Customized inducible overexpressing cell line services for DNASE1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNASE1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DNASE1

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/6 Interacting proteins for DNASE1 (P24855³ ENSP00000246949⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACTB	P60709³, ENSP00000349960⁴	I2D: score=3 STRING: ENSP00000349960
ACTA1	P68133³, ENSP00000355645⁴	I2D: score=3 STRING: ENSP00000355645
ACTG1	P63261³, ENSP00000331514⁴	I2D: score=2 STRING: ENSP00000331514
ACTA2	P62736³, ENSP00000224784⁴	I2D: score=2 STRING: ENSP00000224784
AICDA	Q9GZX7³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006308	DNA catabolic process	IEA	--
GO:0006915	apoptotic process	IEA	--

DNASE1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DNASE1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DNASE1
UniProtKB/Swiss-Prot: DNAS1_HUMAN, P24855

Pharmaceutical: Available under the name Pulmozyme (Genentech). Used to reduce the viscosity of cystic fibrosis sputum

by hydrolyzing the extracellular DNA released by degenerating leukocytes that accumulate in response to infection

2 HMDB Compounds for DNASE1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Magnesium	Magnesium (see all 2)	7439-95-4	--

1 DrugBank Compound for DNASE1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Alpha-D-Mannose	--	3458-28-4	target	--	10592235

10/121 Novoseek chemical compound relationships for DNASE1 gene (see all 121) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dimethyl sulfate	79.4	39	19378167 (2), 1729591 (2), 8218210 (1), 8993038 (1) (see all 27)
bepi	70.5	2	8639533 (1), 8604349 (1)
n-methylpyrrole	68.1	3	20338768 (1), 10753636 (1), 19926483 (1)
dhs1	65.6	2	11181063 (1), 16116039 (1)
chloramphenicol	63.8	2	8621633 (1), 8015548 (1)
oligonucleotide	63.3	31	15080668 (2), 8808703 (1), 8876167 (1), 9524225 (1) (see all 27)
netropsin	60.2	6	9058600 (1), 9845351 (1), 1966670 (1), 9770648 (1) (see all 6)
sodium tetrathionate	59.8	1	9450635 (1)
mithramycin	59.7	12	7880543 (2), 1829382 (1), 1827033 (1), 7529756 (1) (see all 10)
echinomycin	57.1	4	8369281 (2), 1762902 (1), 1762903 (1)

Search CenterWatch for drugs/clinical trials and news about DNASE1 / DNAS1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DNASE1 gene:

NM_005223.3

Unigene Clusters for DNASE1:

Deoxyribonuclease I

Hs.629638 [show with all ESTs], Hs.733045 [show with all ESTs]

Unigene Representative Sequences: BX648480, BC095475

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000570769 ENST00000576050 ENST00000570761 ENST00000407479 ENST00000246949(uc002cvr.3)

ENST00000571460 ENST00000570520 ENST00000570376 ENST00000573804 ENST00000570807

ENST00000572237 ENST00000570664 ENST00000576792 ENST00000575479 ENST00000575152(uc002cvu.3)

ENST00000414110

miRNA Products:		OriGene 3'-UTR Clone: DNASE1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DNASE1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DNASE1
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNASE1 (see all 7) OriGene shRNA RFP: DNASE1 OriGene siRNA: DNASE1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNASE1
		Sirion Biotech Custom design and validation of potent shRNA sequences against DNASE1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNASE1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNASE1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DNASE1 (NM_005223)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNASE1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNASE1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNASE1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DNASE1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNASE1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNASE1

Additional cDNA sequence: BC095475.1

14 DOTS entries:

DT.448353 DT.110010 DT.91692234 DT.95287041 DT.40190387 DT.100827945 DT.408947 DT.120677523

DT.454812 DT.80100387 DT.100758825 DT.100827956 DT.120677569 DT.97855786

24/166 AceView cDNA sequences (see all 166):

AI865260 BC029437 BQ278845 BC064332 BC015002 CF142227 AW503252 AI692769

CF143560 BX110155 AI652114 BM989163 AI298489 AI686298 BM789390 AI364061

BE218479 AA283966 BI769025 BM994588 CF138729 CF136985 AW504161 CB050055

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DNASE1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCACACGTGC

About this image

DNASE1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Skeletal Muscle

Hyoid Arch Muscles

Mononuclear Myocytes

Skeletal Muscle

Mandibular Arch Muscles

Mononuclear Myocytes

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DNASE1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DNASE1

SOURCE GeneReport for Unigene clusters: Hs.629638 Hs.733045

UniProtKB/Swiss-Prot: DNAS1_HUMAN, P24855

Tissue specificity: Principally in tissues of the digestive system. Highest levels found in urine, but also relatively

abundant in semen and saliva

SABiosciences Custom PCR Arrays for DNASE1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNASE1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DNASE1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNASE1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNASE1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNASE1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for DNASE1 gene from 3/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DNASE1¹	deoxyribonuclease I	65.35(n) 57.55(a)		395725 NM_206957.1 NP_996840.1
lizard (Anolis carolinensis)	Reptilia	-- --	--	60(a) 59(a)	1 ↔ many 1 ↔ many	AAWZ02036670(16766-23809) GL343691.1(64032-73437)
zebrafish (Danio rerio)	Actinopterygii	Dr.19519²	Transcribed sequence with weak similarity to protein spP24855 (H.sapiens) DRN1_HUMAN Deoxyribonuclease I precursor (DNase I) (Dornase alfa) less	82.62(n)		AL913333.1

ENSEMBL Gene Tree for DNASE1 (if available)
TreeFam Gene Tree for DNASE1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DNASE1 gene

DNASE1L3² DNASE1L2² DNASE1L1²

3 SIMAP similar genes for DNASE1 using alignment to 10 protein entries: DNAS1_HUMAN (see all proteins):

DNASE1L2 DNASE1L3 DNASE1L1

DNASE1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: DNAS1_HUMAN, P24855

Polymorphism: At least 6 alleles of DNASE1 are known: DNASE1*1 to DNASE1*6. The sequence shown is that of DNASE1*2

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1053874^1,2	C,F,A,H	other	3676856(+)	`GCTCCG/AAGGCG`	2	/Q /R	mis¹		37		EA NA MN NS WA CSA EU	10870
rs9928274^1,2	C,F,A,H	--	3670879(+)	`CAGCAT/CTGACT`	1	--	us2k¹		12		NS EA NA WA	1488
rs75148058^1,2		--	3671083(+)	`CTCCTC/TCAGGG`	1	--	us2k¹		0	--	--	--	--
rs3810816^1,2	C,F,H	--	3671291(+)	`ACCCTC/TGTCCC`	1	--	us2k¹		14		NS EA NA	2216
rs73505454^1,2	C	--	3671425(+)	`TACTCC/TCTTCC`	1	--	us2k¹		2		WA	120
rs8055146^1,2	C,F,H	--	3671507(+)	`CGAATA/GCTCCG`	1	--	us2k¹		12		NS EA NA WA	1484
rs73505456^1,2	C	--	3671937(+)	`AATCCC/TGCCTG`	1	--	us2k¹		1		WA	2
rs74005841^1,2	C	--	3672253(+)	`AGGAAA/TGCCAA`	1	--	ut5¹		2		WA	120
rs45564535^1,2	C,F	--	3672305(+)	`NNNNCA/CACCGC`	1	--	ut5¹		2		NA EA	240
rs112878652^1,2	C	--	3672331(+)	`GGCGCA/GAGGTC`	1	--	ut5¹		2		CSA WA	120

HapMap Linkage Disequilibrium report for DNASE1 (3661729 - 3730144 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DNASE1: --
Human Gene Mutation Database (HGMD): DNASE1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNASE1

DNA2.0 Custom Variant and Variant Library Synthesis for DNASE1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DNASE1 for disorders           About GeneDecksing

OMIM gene information: 125505
OMIM disorders: 152700
UniProtKB/Swiss-Prot: DNAS1_HUMAN, P24855

Defects in DNASE1 are a cause of susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. A chronic,

inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints,

kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune

system

20/64 diseases for DNASE1 (see all 64): About MalaCards

systemic lupus erythematosus lupus erythematosus cystic fibrosis fibrosis

dna topoisomerase ii myocardial infarction acute myocardial infarction sle susceptibility

lupus nephritis cockayne syndrome werner syndrome ischemic heart disease

angelman syndrome wilms tumor acute promyelocytic leukemia pituitary tumor

bronchitis nephritis down syndrome dilated cardiomyopathy

2 diseases from the University of Copenhagen DISEASES database for DNASE1:

Cystic fibrosis Lupus erythematosus

10/64 Novoseek disease relationships for DNASE1 gene (see all 64) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
erythroleukemia	59.1	6	14506241 (1), 8360172 (1), 7615541 (1), 11241278 (1) (see all 6)
cystic fibrosis	51.9	48	9476859 (3), 8711640 (2), 19807335 (2), 7606951 (2) (see all 34)
choriocarcinoma	33.1	1	10715552 (1)
carcinoma embryonal	26.3	1	10644833 (1)
lupus erythematosus systemic	24.1	15	19863681 (2), 14872509 (1), 9660804 (1), 11479590 (1) (see all 9)
hepatoblastoma	19.5	1	9852068 (1)
immunodeficiency	17.6	23	16236265 (1), 19223184 (1), 8051074 (1), 7537089 (1) (see all 22)
cervical carcinoma	10.9	2	17439396 (1), 7507697 (1)
leukemia	9.15	6	9808573 (1), 1703303 (1), 11867721 (1), 12183432 (1) (see all 6)
cell damage	4.73	1	17468836 (1)

Genetic Association Database (GAD): DNASE1
Human Genome Epidemiology (HuGE) Navigator: DNASE1 (22 documents)

Export disorders for DNASE1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DNASE1 gene, integrated from 9 sources (see all 791):
(articles sorted by number of sources associating them with DNASE1)

Utopia: connect your pdf to the dynamic
world of online information

Analysis of genetic polymorphism of deoxyribonuclease I in Ovambo and Turk populations using a genotyping method. (PubMed id 16382368)^{1, 4, 9} Fujihara J....Takeshita H. (2005)
Characterization of human deoxyribonuclease I gene (DNASE1) promoters reveals the utilization of two transcription-starting exons and the involvement of Sp1 in its transcriptional regulation. (PubMed id 16771825)^{1, 2, 9} Kominato Y.... Yasuda T. (2006)
Mutation of DNASE1 in people with systemic lupus erythematosus. (PubMed id 11479590)^{1, 2, 9} Yasutomo K....Kuroda Y. (2001)
Structure of the human deoxyribonuclease I (DNase I) gene: identification of the nucleotide substitution that generates its classical genetic polymorphism. (PubMed id 7762978)^{1, 2, 9} Yasuda T.... Yoshida A. (1995)
Geographical north-south decline in DNASE1*2 in Japanese populations. (PubMed id 11332641)^{1, 4, 9} Takeshita H....Kimura H. (2001)
The fifth allele of the human deoxyribonuclease I (DNase I) polymorphism. (PubMed id 9420147)^{1, 2, 9} Iida R.... Kishi K. (1997)
DNase I mediates internucleosomal DNA degradation in human cells undergoing drug-induced apoptosis. (PubMed id 11241278)^{1, 2, 9} Oliveri M.... Puccetti A. (2001)
Human genetically polymorphic deoxyribonuclease: purification, characterization, and multiplicity of urine deoxyribonuclease I. (PubMed id 2277032)^{1, 2, 9} Yasuda T.... Kishi K. (1990)
Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum. (PubMed id 2251263)^{1, 2, 9} Shak S.... Baker C.L. (1990)
Common DNase I polymorphism associated with autoantibody production among systemic lupus erythematosus patients. (PubMed id 15333586)^{1, 4, 9} Shin H.D....Bae S.C. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1773	HGNC: 2956	AceView: DNASE1	Ensembl:ENSG00000213918	euGenes: HUgn1773
ECgene: DNASE1	H-InvDB: DNASE1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DNASE1	Pharmacogenomics, SNPs, Pathways
Pulmozyme	http://www.pulmozyme.com/index.jsp
Wikipedia	http://en.wikipedia.org/wiki/Deoxyribonuclease

Intellectual Property for DNASE1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DNASE1 gene:
Search GeneIP for patents involving DNASE1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of DNASE1
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for DNASE1		OriGene shRNA RFP for DNASE1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNASE1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNASE1
	OriGene Protein Over-expression Lysate for DNASE1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for DNASE1		OriGene 3'-UTR Clone for DNASE1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNASE1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNASE1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for DNASE1		OriGene Custom Protein Services for DNASE1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DNASE1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNASE1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNASE1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNASE1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNASE1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNASE1

	GenScript Custom Purified and Recombinant Proteins Services for DNASE1		GenScript cDNA clones with any tag delivered in your preferred vector for DNASE1
	GenScript Custom Assay Services for DNASE1		GenScript Custom Superior Antibodies Services for DNASE1
	GenScript Custom overexpressing Cell Line Services for DNASE1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in DNASE1 promoter
	Search Chromatin IP Primers for DNASE1
	RT² qPCR Primer Assay in human, mouse, rat DNASE1
	Search GNC Networks for DNASE1
	SABiosciences Custom PCR Arrays for DNASE1

Search Tocris compounds for DNASE1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	DNASE1 antibodies
	DNASE1 proteins
	DNASE1 lysates

	Antibodies for DNASE1
	See all of Abcam's Antibodies, Kits and Proteins for DNASE1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for DNASE1

DNASE1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for DNASE1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNASE1

	Browse SwitchGear 3'UTR luciferase reporter plasmids for DNASE1
	SwitchGear Promoter luciferase reporter plasmids for DNASE1

ThermoFisher Antibodies for DNASE1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNASE1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DNASE1

Sirion Biotech Customized:

	stable knockdown cell line services for DNASE1
	inducible knockdown cell line services for DNASE1
	design and validation of potent shRNA sequences against DNASE1
	adenovirus for potent knockdown of DNASE1
	adenovirus for overexpression of DNASE1
	stable overexpressing cell line services for DNASE1
	inducible overexpressing cell line services for DNASE1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes DNASE1 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

DNASE1 Gene

deoxyribonuclease I

Aliases
for DNASE1 gene

Summaries
for DNASE1 gene

Genomic Views
for DNASE1 gene

Proteins
for DNASE1 gene

Protein Domains /
Families
for DNASE1 gene

Function
for DNASE1 gene

Pathways & Interactions
for DNASE1 gene

Drugs & Compounds
for DNASE1 gene

Transcripts
for DNASE1 gene

Expression
for DNASE1 gene

Orthologs
for DNASE1 gene

Paralogs
for DNASE1 gene

Genomic Variants
for DNASE1 gene

Disorders / Diseases
for DNASE1 gene

Publications
for DNASE1 gene

External Searches for DNASE1 gene

Genome Databases showing DNASE1 gene

Other Databases showing DNASE1 gene

Specialized Databases showing DNASE1 gene

Intellectual Property
for DNASE1 gene

Products
for DNASE1 gene

View Random Gene

Down Syndrome
Pituitary Tumors
Acute myocardial infarction
Erythroleukemia
Lymphoma T-Cell
Cystic Fibrosis
Myocardial Ischemia
Ischemia
Liver diseases
Breast Cancer
AIDS
Asthma
cell damage
Cancer
Obstruction
Colorectal Carcinoma
Lymphoma
Atelectasis
Pathological Processes
GASTRIC CARCINOMA
Shock
RENAL DISEASE
Tuberculosis
Insulinoma
immunodeficiency
Hepatitis B
Anemia
MYELOMA
ENDOMETRIAL CARCINOMA
Tumors
Fibrosarcoma
Autoimmunity
Necrosis
Hepatoblastoma
Melanoma
BREAST CARCINOMA
Autoimmune Diseases
Colon Cancer
Glioma
Carcinoma
Astrocytoma
Leukemia
Werner Syndrome
Alzheimers Disease
Angelman Syndrome
HEPATOCELLULAR CARCINOMA
CERVICAL CARCINOMA
Bronchitis Chronic
Pancreatic Cancer
Cancer Lung
chronic pancreatitis
Myocardial Infarction
Influenza
Wilms tumor
Response Acute Phase
Bleeding
Lung diseases
PANCREATIC CARCINOMA
Lupus Nephritis
Cockayne Syndrome
Carcinoma Embryonal
Cholera
Lupus Erythematosus Systemic
Choriocarcinoma

Advanced Search

Export list of displayed genes

DNASE1 Gene

deoxyribonuclease I

Aliasesfor DNASE1 gene

Summariesfor DNASE1 gene

Genomic Viewsfor DNASE1 gene

Proteinsfor DNASE1 gene

Protein Domains /Familiesfor DNASE1 gene

Functionfor DNASE1 gene

Pathways & Interactionsfor DNASE1 gene

Drugs & Compoundsfor DNASE1 gene

Transcriptsfor DNASE1 gene

Expression for DNASE1 gene

Orthologsfor DNASE1 gene

Paralogsfor DNASE1 gene

Genomic Variantsfor DNASE1 gene

Disorders / Diseasesfor DNASE1 gene

Publicationsfor DNASE1 gene

External Searches for DNASE1 gene

Genome Databases showing DNASE1 gene

Other Databases showing DNASE1 gene

Specialized Databases showing DNASE1 gene

Intellectual Propertyfor DNASE1 gene

Productsfor DNASE1 gene

View Random Gene

Aliases
for DNASE1 gene

Summaries
for DNASE1 gene

Genomic Views
for DNASE1 gene

Proteins
for DNASE1 gene

Protein Domains /
Families
for DNASE1 gene

Function
for DNASE1 gene

Pathways & Interactions
for DNASE1 gene

Drugs & Compounds
for DNASE1 gene

Transcripts
for DNASE1 gene

Expression
for DNASE1 gene

Orthologs
for DNASE1 gene

Paralogs
for DNASE1 gene

Genomic Variants
for DNASE1 gene

Disorders / Diseases
for DNASE1 gene

Publications
for DNASE1 gene

Intellectual Property
for DNASE1 gene

Products
for DNASE1 gene