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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DNASE1 Gene

protein-coding GIFtS: 62
GCID: GC16P003663

deoxyribonuclease I

(Previous symbol: DNL1)

Explore 64 diseases affiliated with
DNASE1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Deoxyribonuclease I¹ ² ³		Deoxyribonuclease-1¹
DNL1¹ ² ³ ⁵		DNase I, Lysosomal²
DRNI² ³		Human Urine Deoxyribonuclease I²
Dornase Alfa² ³		DNase I³
EC 3.1.21.1³ ⁸

External Ids:	HGNC: 2956¹	Entrez Gene: 1773²	Ensembl: ENSG00000213918⁷	OMIM: 125505⁵	UniProtKB: P24855³

Export aliases for DNASE1 gene to outside databases

Previous GC identifers: GC16P003733 GC16P003704 GC16P003630 GC16P003692

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DNASE1:

This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope

and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been

characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this

gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this

protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and

reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been

thoroughly characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DNAS1_HUMAN, P24855

Function: Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and

blocks actin polymerization (By similarity)

Gene Wiki entry for DNASE1 (Deoxyribonuclease I)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DNASE1 gene promoter:
GR AML1a GR-beta Tal-1beta E47 CP2 GR-alpha MRF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): DNASE1 promoter sequence

Search SABiosciences Chromatin IP Primers for DNASE1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNASE1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

DNASE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNASE1 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P003663: view genomic region (about GC identifiers)

Start:	3,661,729 bp from pter	End:	3,730,144 bp from pter
Size:	68,416 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DNAS1_HUMAN, P24855 (See protein sequence)

Recommended Name: Deoxyribonuclease-1 precursor

Size: 282 amino acids; 31434 Da

Cofactor: Divalent cations. Prefers calcium or magnesium

Subcellular location: Secreted. Nucleus envelope. Note=Secretory protein, stored in zymogen granules and found in the

nuclear envelope

1 PDB 3D structure from and Proteopedia for DNASE1:

4AWN (3D)

Secondary accessions: Q14UU9 Q14UV0

Explore the universe of human proteins at neXtProt for DNASE1: NX_P24855

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P24855

4/9 DME Specific Peptides for DNASE1 (P24855) (see all 9)

FAIVPLH

YKERYLF

CAYDRIV

AVGKLLD

DNASE1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005214.2

ENSEMBL proteins:

ENSP00000458467 ENSP00000461745 ENSP00000385905 ENSP00000246949 ENSP00000459850

ENSP00000461725 ENSP00000458959 ENSP00000461527 ENSP00000459507 ENSP00000461129

ENSP00000461153 ENSP00000416699

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	Novus Biologicals DNASE1 Proteins Novus Biologicals DNASE1 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for DNASE1
	Uscn Proteins for DNASE1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005635	nuclear envelope	IEA	--

DNASE1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for DNASE1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DNASE1 for domains About GeneDecksing

4 InterPro domains/families:

IPR016202 DNase_I-like

IPR005135 Endo/exonuclease/phosphatase

IPR008185 DNase_I_euk

IPR018057 Deoxyribonuclease-1_AS

Graphical View of Domain Structure for InterPro Entry P24855

ProtoNet protein and cluster: P24855

1 Blocks protein family: IPB008185 Deoxyribonuclease I

UniProtKB/Swiss-Prot: DNAS1_HUMAN, P24855

Similarity: Belongs to the DNase I family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DNAS1_HUMAN, P24855

Function: Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and

blocks actin polymerization (By similarity)

Catalytic activity: Endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end-products

Genatlas biochemistry entry for DNASE1:

deoxyribonuclease I,involved in nuclear DNA degradation during apoptosis

Enzyme Number (IUBMB): EC 3.1.21.1¹ ²

miRNA Products:		OriGene 3'-UTR Clone: DNASE1 Browse MicroRNA Expression Plasmids
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DNASE1

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		Search LifeMap BioReagents cell lines for DNASE1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNASE1

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0004530	deoxyribonuclease I activity	IEA	--
GO:0004536	deoxyribonuclease activity	--	--
GO:0005515	protein binding	IPI	12849983
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	--	--

DNASE1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for DNASE1:

Proliferating cells

Animal Models:
Mouse knock-out Dnase1^tm1Tmo for DNASE1
6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dnase1):

cellular	hematopoietic system	homeostasis/metabolism	immune system	mortality/aging
renal/urinary system

DNASE1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DNASE1

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/6 Interacting proteins for DNASE1 (P24855³ ENSP00000246949⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACTB	P60709³, ENSP00000349960⁴	I2D: score=3 STRING: ENSP00000349960
ACTA1	P68133³, ENSP00000355645⁴	I2D: score=3 STRING: ENSP00000355645
ACTG1	P63261³, ENSP00000331514⁴	I2D: score=2 STRING: ENSP00000331514
ACTA2	P62736³, ENSP00000224784⁴	I2D: score=2 STRING: ENSP00000224784
AICDA	Q9GZX7³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006308	DNA catabolic process	IEA	--
GO:0006915	apoptotic process	IEA	--

DNASE1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DNASE1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DNASE1
UniProtKB/Swiss-Prot: DNAS1_HUMAN, P24855

Pharmaceutical: Available under the name Pulmozyme (Genentech). Used to reduce the viscosity of cystic fibrosis sputum

by hydrolyzing the extracellular DNA released by degenerating leukocytes that accumulate in response to infection

2 HMDB Compounds for DNASE1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Magnesium	Magnesium (see all 2)	7439-95-4	--

1 DrugBank Compound for DNASE1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Alpha-D-Mannose	--	3458-28-4	target	--	10592235

10/121 Novoseek chemical compound relationships for DNASE1 gene (see all 121) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dimethyl sulfate	79.4	39	19378167 (2), 1729591 (2), 8218210 (1), 8993038 (1) (see all 27)
bepi	70.5	2	8639533 (1), 8604349 (1)
n-methylpyrrole	68.1	3	20338768 (1), 10753636 (1), 19926483 (1)
dhs1	65.6	2	11181063 (1), 16116039 (1)
chloramphenicol	63.8	2	8621633 (1), 8015548 (1)
oligonucleotide	63.3	31	15080668 (2), 8808703 (1), 8876167 (1), 9524225 (1) (see all 27)
netropsin	60.2	6	9058600 (1), 9845351 (1), 1966670 (1), 9770648 (1) (see all 6)
sodium tetrathionate	59.8	1	9450635 (1)
mithramycin	59.7	12	7880543 (2), 1829382 (1), 1827033 (1), 7529756 (1) (see all 10)
echinomycin	57.1	4	8369281 (2), 1762902 (1), 1762903 (1)

Search CenterWatch for drugs/clinical trials and news about DNASE1 / DNAS1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DNASE1 gene:

NM_005223.3

Unigene Clusters for DNASE1:

Deoxyribonuclease I

Hs.629638 [show with all ESTs], Hs.733045 [show with all ESTs]

Unigene Representative Sequences: BX648480, BC095475

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000570769 ENST00000576050 ENST00000570761 ENST00000407479 ENST00000246949(uc002cvr.3)

ENST00000571460 ENST00000570520 ENST00000570376 ENST00000573804 ENST00000570807

ENST00000572237 ENST00000570664 ENST00000576792 ENST00000575479 ENST00000575152(uc002cvu.3)

ENST00000414110

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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNASE1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNASE1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNASE1

Additional cDNA sequence: BC095475.1

14 DOTS entries:

DT.448353 DT.110010 DT.91692234 DT.95287041 DT.40190387 DT.100827945 DT.408947 DT.120677523

DT.454812 DT.80100387 DT.100758825 DT.100827956 DT.120677569 DT.97855786

24/166 AceView cDNA sequences (see all 166):

AI865260 BC029437 BQ278845 BC064332 BC015002 CF142227 AW503252 AI692769

CF143560 BX110155 AI652114 BM989163 AI298489 AI686298 BM789390 AI364061

BE218479 AA283966 BI769025 BM994588 CF138729 CF136985 AW504161 CB050055

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DNASE1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCACACGTGC

About this image

DNASE1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Skeletal Muscle

Hyoid Arch Muscles

Mononuclear Myocytes

Skeletal Muscle

Mandibular Arch Muscles

Mononuclear Myocytes

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DNASE1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DNASE1

SOURCE GeneReport for Unigene clusters: Hs.629638 Hs.733045

UniProtKB/Swiss-Prot: DNAS1_HUMAN, P24855

Tissue specificity: Principally in tissues of the digestive system. Highest levels found in urine, but also relatively

abundant in semen and saliva

SABiosciences Custom PCR Arrays for DNASE1

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNASE1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for DNASE1 gene from 3/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DNASE1¹	deoxyribonuclease I	65.35(n) 57.55(a)		395725 NM_206957.1 NP_996840.1
lizard (Anolis carolinensis)	Reptilia	-- --	--	60(a) 59(a)	1 ↔ many 1 ↔ many	AAWZ02036670(16766-23809) GL343691.1(64032-73437)
zebrafish (Danio rerio)	Actinopterygii	Dr.19519²	Transcribed sequence with weak similarity to protein more	82.62(n)		AL913333.1

ENSEMBL Gene Tree for DNASE1 (if available)
TreeFam Gene Tree for DNASE1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DNASE1 gene

DNASE1L3² DNASE1L2² DNASE1L1²

3 SIMAP similar genes for DNASE1 using alignment to 10 protein entries: DNAS1_HUMAN (see all proteins):

DNASE1L2 DNASE1L3 DNASE1L1

DNASE1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: DNAS1_HUMAN, P24855

Polymorphism: At least 6 alleles of DNASE1 are known: DNASE1*1 to DNASE1*6. The sequence shown is that of DNASE1*2

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1053874^1,2	C,F,A,H,	other	3676856(+)	`GCTCCG/AAGGCG`	2	/Q /R	mis¹		37		EA NA MN NS WA CSA EU	10870
rs9928274^1,2	C,F,A,H,	--	3670879(+)	`CAGCAT/CTGACT`	1	--	us2k¹		12		NS EA NA WA	1488
rs75148058^1,2		--	3671083(+)	`CTCCTC/TCAGGG`	1	--	us2k¹		0	--	--	--	--
rs3810816^1,2	C,F,H,	--	3671291(+)	`ACCCTC/TGTCCC`	1	--	us2k¹		14		NS EA NA	2216
rs73505454^1,2	C,	--	3671425(+)	`TACTCC/TCTTCC`	1	--	us2k¹		2		WA	120
rs8055146^1,2	C,F,H,	--	3671507(+)	`CGAATA/GCTCCG`	1	--	us2k¹		12		NS EA NA WA	1484
rs73505456^1,2	C,	--	3671937(+)	`AATCCC/TGCCTG`	1	--	us2k¹		1		WA	2
rs74005841^1,2	C,	--	3672253(+)	`AGGAAA/TGCCAA`	1	--	ut5¹		2		WA	120
rs45564535^1,2	C,F,	--	3672305(+)	`NNNNCA/CACCGC`	1	--	ut5¹		2		NA EA	240
rs112878652^1,2	C,	--	3672331(+)	`GGCGCA/GAGGTC`	1	--	ut5¹		2		CSA WA	120

HapMap Linkage Disequilibrium report for DNASE1 (3661729 - 3730144 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DNASE1: --
Human Gene Mutation Database (HGMD): DNASE1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNASE1

DNA2.0 Custom Variant and Variant Library Synthesis for DNASE1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DNASE1 for disorders           About GeneDecksing

OMIM gene information: 125505
OMIM disorders: 152700
UniProtKB/Swiss-Prot: DNAS1_HUMAN, P24855

Defects in DNASE1 are a cause of susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. A chronic,

inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints,

kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune

system

20/64 diseases for DNASE1 (see all 64): About MalaCards

systemic lupus erythematosus lupus erythematosus cystic fibrosis fibrosis

dna topoisomerase ii myocardial infarction acute myocardial infarction sle susceptibility

lupus nephritis cockayne syndrome werner syndrome ischemic heart disease

angelman syndrome wilms tumor acute promyelocytic leukemia pituitary tumor

bronchitis nephritis down syndrome dilated cardiomyopathy

2 diseases from the University of Copenhagen DISEASES database for DNASE1:

Cystic fibrosis Lupus erythematosus

10/64 Novoseek disease relationships for DNASE1 gene (see all 64) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
erythroleukemia	59.1	6	14506241 (1), 8360172 (1), 7615541 (1), 11241278 (1) (see all 6)
cystic fibrosis	51.9	48	9476859 (3), 8711640 (2), 19807335 (2), 7606951 (2) (see all 34)
choriocarcinoma	33.1	1	10715552 (1)
carcinoma embryonal	26.3	1	10644833 (1)
lupus erythematosus systemic	24.1	15	19863681 (2), 14872509 (1), 9660804 (1), 11479590 (1) (see all 9)
hepatoblastoma	19.5	1	9852068 (1)
immunodeficiency	17.6	23	16236265 (1), 19223184 (1), 8051074 (1), 7537089 (1) (see all 22)
cervical carcinoma	10.9	2	17439396 (1), 7507697 (1)
leukemia	9.15	6	9808573 (1), 1703303 (1), 11867721 (1), 12183432 (1) (see all 6)
cell damage	4.73	1	17468836 (1)

Genetic Association Database (GAD): DNASE1
Human Genome Epidemiology (HuGE) Navigator: DNASE1 (22 documents)

Export disorders for DNASE1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DNASE1 gene, integrated from 9 sources (see all 791):
(articles sorted by number of sources associating them with DNASE1)

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Analysis of genetic polymorphism of deoxyribonuclease I in Ovambo and Turk populations using a genotyping method. (PubMed id 16382368)^{1, 4, 9} Fujihara J....Takeshita H. (2005)
Characterization of human deoxyribonuclease I gene (DNASE1) promoters reveals the utilization of two transcription-starting exons and the involvement of Sp1 in its transcriptional regulation. (PubMed id 16771825)^{1, 2, 9} Kominato Y.... Yasuda T. (2006)
Mutation of DNASE1 in people with systemic lupus erythematosus. (PubMed id 11479590)^{1, 2, 9} Yasutomo K....Kuroda Y. (2001)
Structure of the human deoxyribonuclease I (DNase I) gene: identification of the nucleotide substitution that generates its classical genetic polymorphism. (PubMed id 7762978)^{1, 2, 9} Yasuda T.... Yoshida A. (1995)
Geographical north-south decline in DNASE1*2 in Japanese populations. (PubMed id 11332641)^{1, 4, 9} Takeshita H....Kimura H. (2001)
The fifth allele of the human deoxyribonuclease I (DNase I) polymorphism. (PubMed id 9420147)^{1, 2, 9} Iida R.... Kishi K. (1997)
DNase I mediates internucleosomal DNA degradation in human cells undergoing drug-induced apoptosis. (PubMed id 11241278)^{1, 2, 9} Oliveri M.... Puccetti A. (2001)
Human genetically polymorphic deoxyribonuclease: purification, characterization, and multiplicity of urine deoxyribonuclease I. (PubMed id 2277032)^{1, 2, 9} Yasuda T.... Kishi K. (1990)
Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum. (PubMed id 2251263)^{1, 2, 9} Shak S.... Baker C.L. (1990)
Common DNase I polymorphism associated with autoantibody production among systemic lupus erythematosus patients. (PubMed id 15333586)^{1, 4, 9} Shin H.D....Bae S.C. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1773	HGNC: 2956	AceView: DNASE1	Ensembl:ENSG00000213918	euGenes: HUgn1773
ECgene: DNASE1	H-InvDB: DNASE1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DNASE1	Pharmacogenomics, SNPs, Pathways
Pulmozyme	http://www.pulmozyme.com/index.jsp
Wikipedia	http://en.wikipedia.org/wiki/Deoxyribonuclease

Intellectual Property for DNASE1 gene
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DNASE1 Gene

deoxyribonuclease I

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