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Aliases for DNALI1 Gene

Aliases for DNALI1 Gene

  • Dynein, Axonemal, Light Intermediate Chain 1 2 3
  • Dynein, Axonemal, Light Intermediate Polypeptide 1 2 3
  • DJ423B22.5 (Axonemal Dynein Light Chain (Hp28)) 2 3
  • Inner Dynein Arm Light Chain, Axonemal 3 4
  • Hp28 3 4
  • P28 3 6
  • Axonemal Dynein Light Intermediate Polypeptide 1 3
  • Inner Dynein Arm, Homolog Of Clamydomonas 3
  • Homolog Of Clamydomonas 2
  • Inner Dynein Arm 2
  • DJ423B22.5 3

External Ids for DNALI1 Gene

Previous GeneCards Identifiers for DNALI1 Gene

  • GC01P037857
  • GC01P037077
  • GC01P037449
  • GC01P037451
  • GC01P037452
  • GC01P037691
  • GC01P038023
  • GC01P036139

Summaries for DNALI1 Gene

Entrez Gene Summary for DNALI1 Gene

  • This gene is the human homolog of the Chlamydomonas inner dynein arm gene, p28. The precise function of this gene is not known, however, it is a potential candidate for immotile cilia syndrome (ICS). Ultrastructural defects of the inner dynein arms are seen in patients with ICS. Immotile mutant strains of Chlamydomonas, a biflagellated algae, exhibit similar defects. [provided by RefSeq, Jul 2008]

GeneCards Summary for DNALI1 Gene

DNALI1 (Dynein, Axonemal, Light Intermediate Chain 1) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include microtubule motor activity.

UniProtKB/Swiss-Prot for DNALI1 Gene

  • May play a dynamic role in flagellar motility

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNALI1 Gene

Genomics for DNALI1 Gene

Regulatory Elements for DNALI1 Gene

Genomic Location for DNALI1 Gene

37,556,919 bp from pter
37,566,857 bp from pter
9,939 bases
Plus strand

Genomic View for DNALI1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNALI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNALI1 Gene

Proteins for DNALI1 Gene

  • Protein details for DNALI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Axonemal dynein light intermediate polypeptide 1
    Protein Accession:
    Secondary Accessions:
    • A8K387
    • B4DHN6
    • Q05BL9
    • Q5HYE2
    • Q5TGH0
    • Q7L0I5

    Protein attributes for DNALI1 Gene

    258 amino acids
    Molecular mass:
    29662 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB69193.1; Type=Frameshift; Positions=7, 28, 94, 125, 139, 153; Evidence={ECO:0000305}; Sequence=CAI20553.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI46082.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DNALI1 Gene


neXtProt entry for DNALI1 Gene

Proteomics data for DNALI1 Gene at MOPED

Post-translational modifications for DNALI1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNALI1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DNALI1 Gene

Domains for DNALI1 Gene

Gene Families for DNALI1 Gene

  • DN :Axonemal dyneins

Protein Domains for DNALI1 Gene


Suggested Antigen Peptide Sequences for DNALI1 Gene

Graphical View of Domain Structure for InterPro Entry



  • O14645
  • Belongs to the inner dynein arm light chain family.
genes like me logo Genes that share domains with DNALI1: view

Function for DNALI1 Gene

Molecular function for DNALI1 Gene

UniProtKB/Swiss-Prot Function:
May play a dynamic role in flagellar motility

Gene Ontology (GO) - Molecular Function for DNALI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity TAS 9284741
GO:0005515 protein binding IPI 15383276
GO:0045504 dynein heavy chain binding IEA --
genes like me logo Genes that share ontologies with DNALI1: view

Animal Model Products

miRNA for DNALI1 Gene

miRTarBase miRNAs that target DNALI1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DNALI1 Gene

Localization for DNALI1 Gene

Subcellular locations from

Jensen Localization Image for DNALI1 Gene COMPARTMENTS Subcellular localization image for DNALI1 gene
Compartment Confidence
cytoskeleton 4
cytosol 2
extracellular 2
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DNALI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19944400
GO:0005858 axonemal dynein complex TAS 9284741
GO:0005930 axoneme IDA 23849778
GO:0030175 filopodium IEA --
genes like me logo Genes that share ontologies with DNALI1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DNALI1 Gene

Pathways for DNALI1 Gene

genes like me logo Genes that share pathways with DNALI1: view

Pathways by source for DNALI1 Gene

1 KEGG pathway for DNALI1 Gene

Gene Ontology (GO) - Biological Process for DNALI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 9284741
GO:0007338 single fertilization TAS 9284741
GO:0008152 metabolic process TAS 9284741
genes like me logo Genes that share ontologies with DNALI1: view

Transcripts for DNALI1 Gene

Unigene Clusters for DNALI1 Gene

Dynein, axonemal, light intermediate chain 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNALI1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNALI1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - -
SP2: - - - - -
SP3: - - - -
SP4: -

Relevant External Links for DNALI1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNALI1 Gene

mRNA expression in normal human tissues for DNALI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNALI1 Gene

This gene is overexpressed in Testis (8.9).

Protein differential expression in normal tissues for DNALI1 Gene

This gene is overexpressed in Breast (37.7), Testis (23.7), and Ovary (7.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DNALI1 Gene

SOURCE GeneReport for Unigene cluster for DNALI1 Gene Hs.406050

mRNA Expression by UniProt/SwissProt for DNALI1 Gene

Tissue specificity: Expressed in many tissues. A smaller 0.9 kb and a larger 2.5 kb transcripts were detected at the highest level in the testis, at medium levels in the prostate, heart, liver, lung and pancreas, at low levels in the ovary, skeletal muscle and small intestine. Not detected in spleen, colon epithelium, thymus or peripheral blood leukocytes. The 0.9 kb transcript is expressed at a 20-fold higher level than the 2.5 kb transcript in the testis
genes like me logo Genes that share expressions with DNALI1: view

Expression partners for DNALI1 Gene

In Situ Assay Products

Orthologs for DNALI1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNALI1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DNALI1 35
  • 91.73 (n)
  • 98.06 (a)
  • 88 (a)
(Canis familiaris)
Mammalia DNALI1 35
  • 90.36 (n)
  • 93.17 (a)
  • 97 (a)
(Mus musculus)
Mammalia Dnali1 35
  • 89.66 (n)
  • 95.74 (a)
Dnali1 16
Dnali1 36
  • 96 (a)
(Pan troglodytes)
Mammalia DNALI1 35
  • 99.64 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Dnali1 35
  • 89.66 (n)
  • 96.9 (a)
(Monodelphis domestica)
Mammalia DNALI1 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia DNALI1 36
  • 69 (a)
(Gallus gallus)
Aves DNALI1 35
  • 73.46 (n)
  • 77.65 (a)
  • 77 (a)
(Anolis carolinensis)
Reptilia DNALI1 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnali1 35
  • 72.97 (n)
  • 85.43 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16772 35
(Danio rerio)
Actinopterygii dnali1 35
  • 72.18 (n)
  • 76.77 (a)
dnali1 36
  • 76 (a)
dnali1 36
  • 76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6971 37
  • 49 (a)
CG6971 35
  • 58.37 (n)
  • 60.34 (a)
CG6971 36
  • 57 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004030 35
  • 61.27 (n)
  • 61.41 (a)
(Caenorhabditis elegans)
Secernentea dyla-1 36
  • 31 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5036 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7082 36
  • 80 (a)
Species with no ortholog for DNALI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNALI1 Gene

Gene Tree for DNALI1 (if available)
Gene Tree for DNALI1 (if available)

Paralogs for DNALI1 Gene

No data available for Paralogs for DNALI1 Gene

Variants for DNALI1 Gene

Sequence variations from dbSNP and Humsavar for DNALI1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs6619 -- 37,565,095(+) GACAC(C/T)TGGGA utr-variant-3-prime
rs11749 - 37,557,715(+) GCAGG(C/G/T)AGAAG reference, missense, utr-variant-5-prime
rs177346 -- 37,564,064(+) cccat(C/T)tctac intron-variant
rs215198 -- 37,563,965(+) gtggt(A/G)gctca intron-variant
rs215199 -- 37,564,016(+) atcac(A/T)tgagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNALI1 Gene

Variant ID Type Subtype PubMed ID
nsv483134 CNV Loss 15286789
nsv524834 CNV Gain 19592680
nsv834746 CNV Loss 17160897

Relevant External Links for DNALI1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNALI1 Gene

Disorders for DNALI1 Gene

(1) University of Copenhagen DISEASES for DNALI1 Gene

Relevant External Links for DNALI1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DNALI1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for DNALI1 Gene

Publications for DNALI1 Gene

  1. Complementary deoxyribonucleic acid cloning and characterization of a putative human axonemal dynein light chain gene. (PMID: 9284741) Kastury K. … Bhasin S. (J. Clin. Endocrinol. Metab. 1997) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Recruitment of dynein to the Jurkat immunological synapse. (PMID: 16990435) Combs J. … Poenie M. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3

Products for DNALI1 Gene

Sources for DNALI1 Gene

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