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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DNALI1 Gene

protein-coding GIFtS: 55
GCID: GC01P038023

dynein, axonemal, light intermediate chain 1

(Previous names: dynein, axonemal, light intermediate polypeptide 1 )

Explore 4 diseases affiliated with
DNALI1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Dynein, Axonemal, Light Intermediate Chain 1¹ ²		Inner Dynein Arm Light Chain, Axonemal² ³
Hp28¹		Axonemal Dynein Light Intermediate Polypeptide 1²
P28¹ ² ⁵		DJ423B22.5 (Axonemal Dynein Light Chain (Hp28))²
DJ423B22.5¹		Inner Dynein Arm, Homolog Of Clamydomonas²
Dynein, Axonemal, Light Intermediate Polypeptide 1¹ ²

External Ids:	HGNC: 14353¹	Entrez Gene: 7802²	Ensembl: ENSG00000163879⁷	OMIM: 602135⁵	UniProtKB: O14645³

Export aliases for DNALI1 gene to outside databases

Previous GC identifers: GC01P037857 GC01P037077 GC01P037449 GC01P037451 GC01P037452 GC01P037691 GC01P036139

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DNALI1:

This gene is the human homolog of the Chlamydomonas inner dynein arm gene, p28. The precise function of this gene is

not known, however, it is a potential candidate for immotile cilia syndrome (ICS). Ultrastructural defects of the

inner dynein arms are seen in patients with ICS. Immotile mutant strains of Chlamydomonas, a biflagellated algae,

exhibit similar defects. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IDLC_HUMAN, O14645

Function: May play a dynamic role in flagellar motility

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DNALI1 gene promoter:
GR FAC1 AP-1 p53 FOXO4 GR-alpha Nkx2-5 HNF-3beta
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DNALI1 promoter sequence

Search SABiosciences Chromatin IP Primers for DNALI1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNALI1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.1 Ensembl cytogenetic band: 1p34.3 HGNC cytogenetic band: 1p35.1

DNALI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNALI1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P038023: view genomic region (about GC identifiers)

Start:	38,022,520 bp from pter	End:	38,032,458 bp from pter
Size:	9,939 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IDLC_HUMAN, O14645 (See protein sequence)

Recommended Name: Axonemal dynein light intermediate polypeptide 1

Size: 258 amino acids; 29662 Da

Sequence caution: Sequence=AAB69193.1; Type=Frameshift; Positions=7, 28, 94, 125, 139, 153; Sequence=CAI20553.1;

Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAI46082.1; Type=Erroneous initiation;

Note=Translation N-terminally extended;

Secondary accessions: A8K387 Q05BL9 Q5HYE2 Q5TGH0 Q7L0I5

Explore the universe of human proteins at neXtProt for DNALI1: NX_O14645

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O14645

DNALI1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003453.2

ENSEMBL proteins:

ENSP00000296218 ENSP00000438962

Human Recombinant Protein Products for DNALI1:

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	Uscn Proteins for DNALI1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	19944400
GO:0005858	axonemal dynein complex	TAS	9284741
GO:0005930	axoneme	TAS	9284741

DNALI1 for ontologies About GeneDecksing

DNALI1 Antibody Products:

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Assay Products for DNALI1:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DNALI1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DNALI1 for domains About GeneDecksing

1 InterPro domain/family:

IPR019347 Axonemal_dynein_light_chain

Graphical View of Domain Structure for InterPro Entry O14645

ProtoNet protein and cluster: O14645

UniProtKB/Swiss-Prot: IDLC_HUMAN, O14645

Similarity: Belongs to the inner dynein arm light chain family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: IDLC_HUMAN, O14645

Function: May play a dynamic role in flagellar motility

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003777	microtubule motor activity	TAS	9284741

DNALI1 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DNALI1

miRNA Products:		OriGene 3'-UTR Clone: DNALI1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DNALI1
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate DNALI1 (see all 18):
		hsa-miR-579 hsa-miR-34b* hsa-miR-3607-5p hsa-miR-300 hsa-miR-520d-5p hsa-miR-3660 hsa-miR-4263 hsa-miR-3190

		SwitchGear 3'UTR luciferase reporter plasmid: DNALI1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNALI1 (see all 7) OriGene shRNA RFP: DNALI1 OriGene siRNA: DNALI1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNALI1
		Sirion Biotech Custom design and validation of potent shRNA sequences against DNALI1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for DNALI1
			Sirion Biotech Customized adenovirus for overexpression of DNALI1 Sirion Biotech Customized adenovirus for potent knockdown of DNALI1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNALI1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNALI1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DNALI1 (NM_003462)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNALI1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNALI1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DNALI1
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNALI1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

Huntington's disease

0.40

Cytoskeleton remodeling Neurofilaments

Cytoplasmic microtubules

0.32

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for DNALI1

Cytoplasmic microtubules

1 Kegg Pathway (Kegg details for DNALI1):

Huntington's disease

DNALI1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DNALI1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/41 Interacting proteins for DNALI1 (O14645^{2, 3} ENSP00000296218⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 41)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EPS8	Q12929²^,³, ENSP00000281172⁴	MINT-64089 I2D: score=5 STRING: ENSP00000281172
ABCF3	Q9NUQ8²^,³	MINT-65155 I2D: score=5
HTT	P42858³, ENSP00000347184⁴	I2D: score=2 STRING: ENSP00000347184
MED19	A0JLT2³, ENSP00000337340⁴	STRING: ENSP00000337340 I2D: score=1
MED29	Q9NX70³, ENSP00000314343⁴	I2D: score=1 STRING: ENSP00000314343

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006928	cellular component movement	TAS	9284741
GO:0007338	single fertilization	TAS	9284741

DNALI1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DNALI1
Search CenterWatch for drugs/clinical trials and news about DNALI1 / IDLC

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DNALI1 gene:

NM_003462.3

Unigene Cluster for DNALI1:

Dynein, axonemal, light intermediate chain 1

Hs.406050 [show with all ESTs]

Unigene Representative Sequence: BC039074

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000296218(uc001cbj.3 uc010oie.2) ENST00000467181 ENST00000490312

ENST00000466723 ENST00000497858 ENST00000467277 ENST00000541606

miRNA Products:		OriGene 3'-UTR Clone: DNALI1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DNALI1
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate DNALI1 (see all 18):
		hsa-miR-579 hsa-miR-34b* hsa-miR-3607-5p hsa-miR-300 hsa-miR-520d-5p hsa-miR-3660 hsa-miR-4263 hsa-miR-3190

		SwitchGear 3'UTR luciferase reporter plasmid: DNALI1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNALI1 (see all 7) OriGene shRNA RFP: DNALI1 OriGene siRNA: DNALI1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNALI1
		Sirion Biotech Custom design and validation of potent shRNA sequences against DNALI1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNALI1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNALI1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DNALI1 (NM_003462)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNALI1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNALI1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNALI1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DNALI1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNALI1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNALI1

Additional cDNA sequence:

AK290502.1 AK295199.1 AK299918.1 BC039074.1 BC046117.1 BX647913.1

9 DOTS entries:

DT.414992 DT.99978263 DT.97813181 DT.95361627 DT.95163664 DT.121364353 DT.91691622 DT.95163663

DT.95163665

24/162 AceView cDNA sequences (see all 162):

AW590856 BQ901109 NM_003462 AW002387 BC046117 AW299538 BE219411 BU727066

AI201894 BM693028 AK126963 BF436756 CB850796 AI687555 AL120182 BU730158

AW954110 BX281287 AA402541 BU685715 BE669772 BF435827 BF435330 W45433

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DNALI1 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	·	6c
SP1:											-				-		-
SP2:											-		-		-		-		-
SP3:											-		-		-		-
SP4:											-
SP5:

ECgene alternative splicing isoforms for DNALI1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DNALI1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTAATTTCC

About this image

DNALI1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DNALI1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DNALI1

SOURCE GeneReport for Unigene cluster: Hs.406050

UniProtKB/Swiss-Prot: IDLC_HUMAN, O14645

Tissue specificity: Expressed in many tissues. A smaller 0.9 kb and a larger 2.5 kb transcripts were detected at the

highest level in the testis, at medium levels in the prostate, heart, liver, lung and pancreas, at low levels in the

ovary, skeletal muscle and small intestine. Not detected in spleen, colon epithelium, thymus or peripheral blood

leukocytes. The 0.9 kb transcript is expressed at a 20-fold higher level than the 2.5 kb transcript in the testis

SABiosciences Custom PCR Arrays for DNALI1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNALI1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNALI1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNALI1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DNALI1 gene from 7/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dnali1^{1 , 5}	dynein, axonemal, light intermediate polypeptide 1^{1, 5}	89.66(n)¹ 95.74(a)¹		4 (57.99 cM)⁵ 75563¹ NM_175223.4¹ NP_780432.1¹ 125055338⁵
chicken (Gallus gallus)	Aves	DNALI1¹	dynein, axonemal, light intermediate chain 1	72.22(n) 77.24(a)		419615 XM_003642567.1 XP_003642615.1
lizard (Anolis carolinensis)	Reptilia	DNALI1⁶	--	80(a)	1 ↔ 1	GL343426.1(459095-463529)
African clawed frog (Xenopus laevis)	Amphibia	Xl.16772²	Xenopus laevis transcribed sequence with weak similarity more	77.08(n)		CF287138.1
zebrafish (Danio rerio)	Actinopterygii	dnali1¹	dynein, axonemal, light intermediate chain 1	72.05(n) 77.17(a)		567632 NM_001110114.2 NP_001103584.2
fruit fly (Drosophila melanogaster)	Insecta	CG6971^{1 , 3}	microtubule-based movement dynein ATPase³ CG6971¹	49(a)³ 58.37(n)¹ 60.34(a)¹		87A1³ 41440¹ NM_141871.2¹ NP_650128.1¹
worm (Caenorhabditis elegans)	Secernentea	dyla-1¹	Protein DYLA-1	51.06(n) 46.28(a)		185634 NM_078319.1 NP_510720.1

ENSEMBL Gene Tree for DNALI1 (if available)
TreeFam Gene Tree for DNALI1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113818355^1,2	C	--	36137882(+)	`AGGGGC/TTAGTG`	1	--	us2k¹		0	--	--	--	--
rs61776187^1,2		--	36137953(+)	`GCAGTG/AAGCCG`	1	--	us2k¹		1		NA	2
rs188216871^1,2		--	38020590(+)	`GCAATC/GAGAGA`	2	--	us2k¹		0	--	--	--	--
rs116519477^1,2		--	38020598(+)	`AGATGA/CTAACC`	2	--	us2k¹		1		NA	120
rs193257981^1,2		--	38020603(+)	`ATAACC/GCATGG`	2	--	us2k¹		0	--	--	--	--
rs140836733^1,2		--	38020647(+)	`CCTCTG/TCTATT`	2	--	us2k¹		0	--	--	--	--
rs144758313^1,2		--	38020874(+)	`CTTATA/CCTGTC`	2	--	us2k¹		0	--	--	--	--
rs115893781^1,2		--	38020895(+)	`ATTTAC/AAGCCG`	2	--	us2k¹		1		WA	118
rs150845907^1,2		--	38021065(+)	`AGCAGA/GGACAG`	2	--	us2k¹		0	--	--	--	--
rs139297699^1,2	C	--	38021181(+)	`CAAAA-/TCAAAA`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DNALI1 (38022520 - 38032458 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DNALI1
1 CNV: 0006

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNALI1

DNA2.0 Custom Variant and Variant Library Synthesis for DNALI1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DNALI1 for disorders           About GeneDecksing

OMIM gene information: 602135    OMIM disorders: --

4 diseases for DNALI1:    About MalaCards

ciliary dyskinesia primary ciliary dyskinesia huntington's disease prostatitis

1 disease from the University of Copenhagen DISEASES database for DNALI1:

Primary ciliary dyskinesia

Human Genome Epidemiology (HuGE) Navigator: DNALI1 (1 document)

Export disorders for DNALI1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DNALI1 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with DNALI1)

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Complementary deoxyribonucleic acid cloning and characterization of a putative human axonemal dynein light chain gene. (PubMed id 9284741)^{1, 2, 3, 9} Kastury K.... Bhasin S. (1997)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Deletions and point mutations of LRRC50 cause primary ciliary dyskinesia due to dynein arm defects. (PubMed id 19944400)¹ Loges N.T....Omran H. (2009)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)² Sjoeblom T.... Velculescu V.E. (2006)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7802	HGNC: 14353	AceView: DNALI1	Ensembl:ENSG00000163879	euGenes: HUgn7802
ECgene: DNALI1	Kegg: 7802	H-InvDB: DNALI1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DNALI1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DNALI1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DNALI1 gene:
Search GeneIP for patents involving DNALI1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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DNALI1 Gene

dynein, axonemal, light intermediate chain 1

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DNALI1 Gene

dynein, axonemal, light intermediate chain 1

Aliasesfor DNALI1 gene

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Genomic Viewsfor DNALI1 gene

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Protein Domains /Familiesfor DNALI1 gene

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for DNALI1 gene

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Drugs & Compounds
for DNALI1 gene

Transcripts
for DNALI1 gene

Expression
for DNALI1 gene

Orthologs
for DNALI1 gene

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Genomic Variants
for DNALI1 gene

Disorders / Diseases
for DNALI1 gene

Publications
for DNALI1 gene

Intellectual Property
for DNALI1 gene

Products
for DNALI1 gene