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DNALI1 Gene

protein-coding   GIFtS: 57
GCID: GC01P038023

Dynein, Axonemal, Light Intermediate Chain 1

(Previous names: dynein, axonemal, light intermediate polypeptide 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dynein, Axonemal, Light Intermediate Chain 11 2     Homolog Of Clamydomonas1
Dynein, Axonemal, Light Intermediate Polypeptide 11 2     Inner Dynein Arm1
DJ423B22.5 (Axonemal Dynein Light Chain (Hp28))1 2     Axonemal Dynein Light Intermediate Polypeptide 12
Inner Dynein Arm Light Chain, Axonemal2 3     dJ423B22.52
hp282 3     Inner Dynein Arm, Homolog Of Clamydomonas2
P282 5     

External Ids:    HGNC: 143531   Entrez Gene: 78022   Ensembl: ENSG000001638797   OMIM: 6021355   UniProtKB: O146453   

Export aliases for DNALI1 gene to outside databases

Previous GC identifers: GC01P037857 GC01P037077 GC01P037449 GC01P037451 GC01P037452 GC01P037691 GC01P036139


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNALI1 Gene:
This gene is the human homolog of the Chlamydomonas inner dynein arm gene, p28. The precise function of this gene
is not known, however, it is a potential candidate for immotile cilia syndrome (ICS). Ultrastructural defects of
the inner dynein arms are seen in patients with ICS. Immotile mutant strains of Chlamydomonas, a biflagellated
algae, exhibit similar defects. (provided by RefSeq, Jul 2008)

GeneCards Summary for DNALI1 Gene:
DNALI1 (dynein, axonemal, light intermediate chain 1) is a protein-coding gene. Diseases associated with DNALI1 include primary ciliary dyskinesia, and huntington's disease. GO annotations related to this gene include microtubule motor activity.

UniProtKB/Swiss-Prot: IDLC_HUMAN, O14645
Function: May play a dynamic role in flagellar motility




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNALI1 gene promoter:
         GR   FAC1   AP-1   p53   FOXO4   GR-alpha   Nkx2-5   HNF-3beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNALI1 promoter sequence
   Search Chromatin IP Primers for DNALI1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNALI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.1   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p35.1

DNALI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNALI1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P038023:  view genomic region     (about GC identifiers)

Start:
38,022,520 bp from pter      End:
38,032,458 bp from pter
Size:
9,939 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IDLC_HUMAN, O14645 (See protein sequence)
Recommended Name: Axonemal dynein light intermediate polypeptide 1  
Size: 258 amino acids; 29662 Da
Sequence caution: Sequence=AAB69193.1; Type=Frameshift; Positions=7, 28, 94, 125, 139, 153; Sequence=CAI20553.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAI46082.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K387 Q05BL9 Q5HYE2 Q5TGH0 Q7L0I5

Explore the universe of human proteins at neXtProt for DNALI1: NX_O14645

Explore proteomics data for DNALI1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DNALI1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003453.2  
    ENSEMBL proteins: 
     ENSP00000296218   ENSP00000438962  

    DNALI1 Human Recombinant Protein Products:

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    Novus Biologicals DNALI1 Lysates
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    Cloud-Clone Corp. CLIAs for DNALI1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DN: Axonemal dyneins

    1 InterPro protein domain:
     IPR019347 Axonemal_dynein_light_chain

    Graphical View of Domain Structure for InterPro Entry O14645

    ProtoNet protein and cluster: O14645

    UniProtKB/Swiss-Prot: IDLC_HUMAN, O14645
    Similarity: Belongs to the inner dynein arm light chain family


    DNALI1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IDLC_HUMAN, O14645
    Function: May play a dynamic role in flagellar motility

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity TAS9284741
    GO:0005515protein binding IPI15383276
         
    DNALI1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNALI1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DNALI1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DNALI1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DNALI1

    miRNA
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    miRTarBase miRNAs that target DNALI1:
    hsa-mir-335-5p (MIRT017518)

    Block miRNA regulation of human, mouse, rat DNALI1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNALI1 (see all 18):
    hsa-miR-579 hsa-miR-34b* hsa-miR-3607-5p hsa-miR-300 hsa-miR-520d-5p hsa-miR-3660 hsa-miR-4263 hsa-miR-3190
    SwitchGear 3'UTR luciferase reporter plasmidDNALI1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DNALI1
    Predesigned siRNA for gene silencing in human, mouse, rat DNALI1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for DNALI1

    Clone
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    OriGene clones in human, mouse for DNALI1 (see all 8)
    OriGene ORF clones in mouse, rat for DNALI1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DNALI1 (NM_003462)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNALI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNALI1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DNALI1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNALI1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol2
    extracellular2
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA19944400
    GO:0005858axonemal dynein complex TAS9284741
    GO:0005930axoneme TAS9284741

    DNALI1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DNALI1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Huntington's disease0.45
    2Cytoplasmic microtubules
    Cytoplasmic microtubules0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for DNALI1):
        Huntington's disease


    DNALI1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DNALI1
    Interactions:

        Search GeneGlobe Interaction Network for DNALI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNALI1 (O146451, 2, 3 ENSP000002962184) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EPS8Q129292, 3, ENSP000002811724MINT-64089 I2D: score=5 STRING: ENSP00000281172
    ABCF3Q9NUQ82, 3MINT-65155 I2D: score=5 
    HTTP428583, ENSP000003471844I2D: score=2 STRING: ENSP00000347184
    MED19A0JLT23, ENSP000003373404STRING: ENSP00000337340 I2D: score=1 
    MED29Q9NX703, ENSP000003143434I2D: score=1 STRING: ENSP00000314343
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS9284741
    GO:0007338single fertilization TAS9284741
    GO:0008152metabolic process TAS9284741

    DNALI1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNALI1 (IDLC)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DNALI1 gene: 
    NM_003462.3  

    Unigene Cluster for DNALI1:

    Dynein, axonemal, light intermediate chain 1
    Hs.406050  [show with all ESTs]
    Unigene Representative Sequence: BC039074
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296218(uc001cbj.3 uc010oie.2) ENST00000490312 ENST00000466723
    ENST00000497858 ENST00000467277 ENST00000541606
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DNALI1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNALI1 (see all 18):
    hsa-miR-579 hsa-miR-34b* hsa-miR-3607-5p hsa-miR-300 hsa-miR-520d-5p hsa-miR-3660 hsa-miR-4263 hsa-miR-3190
    SwitchGear 3'UTR luciferase reporter plasmidDNALI1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DNALI1
    Predesigned siRNA for gene silencing in human, mouse, rat DNALI1
    Clone
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    OriGene clones in human, mouse for DNALI1 (see all 8)
    OriGene ORF clones in mouse, rat for DNALI1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DNALI1 (NM_003462)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNALI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNALI1
    Primer
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    OriGene qPCR primer pairs and template standards for DNALI1
    OriGene qSTAR qPCR primer pairs in human, mouse for DNALI1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNALI1
      QuantiTect SYBR Green Assays in human, mouse, rat DNALI1
      QuantiFast Probe-based Assays in human, mouse, rat DNALI1

    Additional mRNA sequence: 

    AK290502.1 AK295199.1 AK299918.1 BC039074.1 BC046117.1 BX647913.1 

    9 DOTS entries:

    DT.414992  DT.99978263  DT.97813181  DT.95361627  DT.95163664  DT.121364353  DT.91691622  DT.95163663 
    DT.95163665 

    Selected AceView cDNA sequences (see all 162):

    AI669545 BF435827 BF436756 BG150228 BE669772 AI361389 AA370797 AI350467 
    AI038561 BQ901109 W45433 AL120182 BF435140 BM693028 BC046117 BF435330 
    AW299538 BE219411 CB850796 AW591871 BU685715 AW954110 AI201894 NM_003462 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DNALI1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:                                -           -     -                                       
    SP2:                                -     -     -     -     -                                 
    SP3:                                -     -     -     -                                       
    SP4:                                -                                                         
    SP5:                                                                                          


    ECgene alternative splicing isoforms for DNALI1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNALI1 expression in normal human tissues (normalized intensities)      DNALI1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTAATTTCC
    DNALI1 Expression
    About this image


    DNALI1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
    DNALI1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNALI1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406050

    UniProtKB/Swiss-Prot: IDLC_HUMAN, O14645
    Tissue specificity: Expressed in many tissues. A smaller 0.9 kb and a larger 2.5 kb transcripts were detected at
    the highest level in the testis, at medium levels in the prostate, heart, liver, lung and pancreas, at low levels
    in the ovary, skeletal muscle and small intestine. Not detected in spleen, colon epithelium, thymus or peripheral
    blood leukocytes. The 0.9 kb transcript is expressed at a 20-fold higher level than the 2.5 kb transcript in the
    testis

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    QuantiFast Probe-based Assays in human, mouse, rat DNALI1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNALI1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DNALI1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnali11 , 5 dynein, axonemal, light intermediate polypeptide 11, 5 89.66(n)1
    95.74(a)1
      4 (57.99 cM)5
    755631  NM_175223.41  NP_780432.11 
     1250553385 
    chicken
    (Gallus gallus)
    Aves DNALI11 dynein, axonemal, light intermediate chain 1 73.46(n)
    77.65(a)
      419615  XM_417762.4  XP_417762.3 
    lizard
    (Anolis carolinensis)
    Reptilia DNALI16
    dynein, axonemal, light intermediate chain 1
    80(a)
    1 ↔ 1
    GL343426.1(458517-468170)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.167722 Xenopus laevis transcribed sequence with weak similarity more 77.08(n)    CF287138.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dnali11 dynein, axonemal, light intermediate chain 1 72.18(n)
    76.77(a)
      567632  NM_001110114.2  NP_001103584.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG69711 , 3 microtubule-based movement dynein
    ATPase3
    CG69711
    49(a)3
    58.37(n)1
    60.34(a)1
      87A13
    414401  NM_141871.31  NP_650128.11 
    worm
    (Caenorhabditis elegans)
    Secernentea dyla-16
    Protein DYLA-1 (dyla-1) mRNA, complete cds
    31(a)
    1 ↔ 1
    X(16841105-16842975) WBGene00018307


    ENSEMBL Gene Tree for DNALI1 (if available)
    TreeFam Gene Tree for DNALI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNALI1 (see all 260)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357014
    A colorectal cancer sample4--see VAR_0357012 I M mis40--------
    rs617433401,2
    --38021970(+) TGCTAT/CAAAAT 1 -- us2k11Minor allele frequency- C:0.02NS 56
    rs1812509371,2
    --38022214(+) TTCCTC/TTGGGA 1 -- us2k10--------
    rs1456318741,2
    --38022231(+) CCTTAA/CCCCTT 1 -- us2k10--------
    rs1869978491,2
    C--38022272(+) TCAGGA/TGACAA 1 -- us2k10--------
    rs1155481761,2
    C,F--38022334(+) GAGCAT/CAGGGA 1 -- us2k11Minor allele frequency- C:0.03NA 120
    rs22730141,2
    C,F,A,H--38022452(+) ACTTGC/ACGGCT 1 -- us2k130Minor allele frequency- A:0.46EA NA NS WA CSA 4300
    rs1145293191,2
    C,F--38022509(+) GGGGCG/AGGAGT 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs757282611,2
    C--38022511(+) GGCGGA/GAGTGA 1 -- us2k10--------
    rs2011284181,2
    C--38022580(+) GTTGCT/CACTCT 2 /A syn11Minor allele frequency- C:0.00EU 987

    HapMap Linkage Disequilibrium report for DNALI1 (38022520 - 38032458 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DNALI1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834746CNV Loss17160897
    nsv483134CNV Loss15286789
    nsv524834CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602135    OMIM disorders: --

    6 diseases for DNALI1:    About MalaCards
    primary ciliary dyskinesia    huntington's disease    breast and colorectal cancer    malaria
    colorectal cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for DNALI1:
    Primary ciliary dyskinesia

    DNALI1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DNALI1
    Human Genome Epidemiology (HuGE) Navigator: DNALI1 (1 document)

    Export disorders for DNALI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNALI1 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with DNALI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complementary deoxyribonucleic acid cloning and characterization of a putative human axonemal dynein light chain gene. (PubMed id 9284741)1, 2, 3, 9 Kastury K.... Bhasin S. (J. Clin. Endocrinol. Metab. 1997)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. (PubMed id 24144296)1 Cheng C.Y....Baird P.N. (Am. J. Hum. Genet. 2013)
    6. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    7. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    9. Deletions and point mutations of LRRC50 cause primary ciliary dyskinesia due to dynein arm defects. (PubMed id 19944400)1 Loges N.T.... Omran H. (Am. J. Hum. Genet. 2009)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7802 HGNC: 14353 AceView: DNALI1 Ensembl:ENSG00000163879 euGenes: HUgn7802
    ECgene: DNALI1 Kegg: 7802 H-InvDB: DNALI1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DNALI1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNALI1 gene:
    Search GeneIP for patents involving DNALI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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