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Aliases for DNAL4 Gene

Aliases for DNAL4 Gene

  • Dynein, Axonemal, Light Chain 4 2 3
  • Dynein, Axonemal, Light Polypeptide 4 2 3
  • Proliferation-Inducing Protein 27 3
  • Dynein Light Chain, Outer Arm 4 3
  • Dynein Light Chain 4, Axonemal 3
  • Proliferation-Inducing Gene 27 3
  • Dynein, Axonemal, Light 4 2
  • MRMV3 3
  • PIG27 3

External Ids for DNAL4 Gene

Summaries for DNAL4 Gene

Entrez Gene Summary for DNAL4 Gene

  • This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. [provided by RefSeq, Dec 2014]

GeneCards Summary for DNAL4 Gene

DNAL4 (Dynein, Axonemal, Light Chain 4) is a Protein Coding gene. Diseases associated with DNAL4 include mirror movements 3. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include microtubule motor activity and ATPase activity, coupled. An important paralog of this gene is DYNLL1.

UniProtKB/Swiss-Prot for DNAL4 Gene

  • Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity).

Gene Wiki entry for DNAL4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAL4 Gene

Genomics for DNAL4 Gene

Genomic Location for DNAL4 Gene

Start:
38,778,508 bp from pter
End:
38,794,198 bp from pter
Size:
15,691 bases
Orientation:
Minus strand

Genomic View for DNAL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAL4 Gene

Regulatory Elements for DNAL4 Gene

Proteins for DNAL4 Gene

  • Protein details for DNAL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O96015-DNAL4_HUMAN
    Recommended name:
    Dynein light chain 4, axonemal
    Protein Accession:
    O96015
    Secondary Accessions:
    • Q6FGB2
    • Q6FGD0

    Protein attributes for DNAL4 Gene

    Size:
    105 amino acids
    Molecular mass:
    12009 Da
    Quaternary structure:
    • Consists of at least two heavy chains and a number of intermediate and light chains

neXtProt entry for DNAL4 Gene

Proteomics data for DNAL4 Gene at MOPED

Post-translational modifications for DNAL4 Gene

No Post-translational modifications

Other Protein References for DNAL4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAL4 Gene

Domains for DNAL4 Gene

Gene Families for DNAL4 Gene

HGNC:
  • DN :Axonemal dyneins

Protein Domains for DNAL4 Gene

Graphical View of Domain Structure for InterPro Entry

O96015

UniProtKB/Swiss-Prot:

DNAL4_HUMAN
Family:
  • Belongs to the dynein light chain family.:
    • O96015
genes like me logo Genes that share domains with DNAL4: view

Function for DNAL4 Gene

Molecular function for DNAL4 Gene

GENATLAS Biochemistry: dynein,axonemal,motor protein interacting with microtubules,light polypeptide 4,outer arm,essential for motility of cilia and flagella,mouse ortholog
UniProtKB/Swiss-Prot Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity).

Gene Ontology (GO) - Molecular Function for DNAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with DNAL4: view

miRNA for DNAL4 Gene

miRTarBase miRNAs that target DNAL4

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DNAL4 Gene

Localization for DNAL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAL4 Gene

Cytoplasm, cytoskeleton, cilium axoneme.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAL4 Gene COMPARTMENTS Subcellular localization image for DNAL4 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 4
cytosol 3
extracellular 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DNAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IEA --
GO:0005875 microtubule associated complex --
GO:0005886 plasma membrane TAS --
GO:0005929 cilium IEA --
genes like me logo Genes that share ontologies with DNAL4: view

Pathways for DNAL4 Gene

genes like me logo Genes that share pathways with DNAL4: view

Pathways by source for DNAL4 Gene

Gene Ontology (GO) - Biological Process for DNAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007017 microtubule-based process IEA --
GO:0008152 metabolic process IEA --
GO:0048011 neurotrophin TRK receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with DNAL4: view

Transcripts for DNAL4 Gene

mRNA/cDNA for DNAL4 Gene

Unigene Clusters for DNAL4 Gene

Dynein, axonemal, light chain 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNAL4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: - - -
SP2: -
SP3: - -
SP4: - - - -
SP5: - - - - -
SP6:

Relevant External Links for DNAL4 Gene

GeneLoc Exon Structure for
DNAL4
ECgene alternative splicing isoforms for
DNAL4

Expression for DNAL4 Gene

mRNA expression in normal human tissues for DNAL4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DNAL4 Gene

SOURCE GeneReport for Unigene cluster for DNAL4 Gene Hs.632766

genes like me logo Genes that share expressions with DNAL4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DNAL4 Gene

Orthologs for DNAL4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNAL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAL4 35
  • 100 (n)
  • 100 (a)
DNAL4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAL4 35
  • 95.87 (n)
  • 100 (a)
DNAL4 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAL4 35
  • 95.24 (n)
  • 99.05 (a)
DNAL4 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnal4 35
  • 93.65 (n)
  • 99.05 (a)
Dnal4 36
  • 99 (a)
OneToOne
Dnalc4 16
oppossum
(Monodelphis domestica)
Mammalia DNAL4 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAL4 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnal4 35
  • 93.33 (n)
  • 97.14 (a)
chicken
(Gallus gallus)
Aves DNAL4 35
  • 83.83 (n)
  • 87.13 (a)
DNAL4 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAL4 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4120 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dnal4 35
  • 78.22 (n)
  • 88.12 (a)
Str.16730 35
zebrafish
(Danio rerio)
Actinopterygii dnal4a 36
  • 85 (a)
OneToMany
dnal4b 35
  • 75.82 (n)
  • 87.25 (a)
dnal4b 36
  • 86 (a)
OneToMany
Dr.14387 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006887 35
  • 67.71 (n)
  • 60.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8407 35
  • 69.23 (n)
  • 59.62 (a)
CG8407 36
  • 60 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dlc-5 36
  • 15 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DYN2 36
  • 30 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6924 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 10 (a)
OneToOne
Species with no ortholog for DNAL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAL4 Gene

ENSEMBL:
Gene Tree for DNAL4 (if available)
TreeFam:
Gene Tree for DNAL4 (if available)

Paralogs for DNAL4 Gene

Paralogs for DNAL4 Gene

Selected SIMAP similar genes for DNAL4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DNAL4: view

Variants for DNAL4 Gene

Sequence variations from dbSNP and Humsavar for DNAL4 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs14040 -- 38,779,262(-) TCAAC(C/T)GTCTC utr-variant-3-prime
rs738144 -- 38,782,370(+) CCTAC(A/G)ATCAT intron-variant
rs738145 -- 38,782,388(+) AAACA(C/T)GTATT intron-variant
rs760482 -- 38,782,696(+) TTATA(A/G)TCAGC synonymous-codon, reference
rs2294180 -- 38,794,091(+) GAGCC(G/T)GGGCC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for DNAL4 Gene

Variant ID Type Subtype PubMed ID
nsv915067 CNV Loss 21882294
nsv915068 CNV Loss 21882294
dgv769n67 CNV Gain 20364138
nsv471199 CNV Loss 18288195
nsv915069 CNV Loss 21882294

Relevant External Links for DNAL4 Gene

HapMap Linkage Disequilibrium report
DNAL4
Human Gene Mutation Database (HGMD)
DNAL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAL4 Gene

Disorders for DNAL4 Gene

UniProtKB/Swiss-Prot

DNAL4_HUMAN
  • Mirror movements 3 (MRMV3) [MIM:616059]: A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities. {ECO:0000269 PubMed:25098561}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) MalaCards Diseases for DNAL4 Gene

Search for DNAL4 Gene in MalaCards »
genes like me logo Genes that share disorders with DNAL4: view

Publications for DNAL4 Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4
  2. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PMID: 12529303) Collins J.E. … Dunham I. (Genome Res. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Identification of a homozygous splice site mutation in the dynein axonemal light chain 4 gene on 22q13.1 in a large consanguineous family from Pakistan with congenital mirror movement disorder. (PMID: 25098561) Ahmed I. … Vincent J.B. (Hum. Genet. 2014) 3 4
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for DNAL4 Gene

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