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DNAL4 Gene

protein-coding   GIFtS: 55
GCID: GC22M039174

Dynein, Axonemal, Light Chain 4

(Previous names: dynein, axonemal, light polypeptide 4, dynein, axonemal,...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dynein, Axonemal, Light Chain 41 2     Dynein Light Chain 4, Axonemal2
Dynein, Axonemal, Light 41 2     Dynein Light Chain, Outer Arm 42
Dynein, Axonemal, Light Polypeptide 41 2     Proliferation-Inducing Gene 272
PIG272     Proliferation-Inducing Protein 272

External Ids:    HGNC: 29551   Entrez Gene: 101262   Ensembl: ENSG000001002467   OMIM: 6105655   UniProtKB: O960153   

Export aliases for DNAL4 gene to outside databases

Previous GC identifers: GC22M035789 GC22M037417 GC22M037499 GC22M022140


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNAL4 Gene:
DNAL4 is a component of the dynein motor complex (Iwasaki et al., 2005 (PubMed 15454493)).(supplied by OMIM, Mar
2008)

GeneCards Summary for DNAL4 Gene:
DNAL4 (dynein, axonemal, light chain 4) is a protein-coding gene. GO annotations related to this gene include microtubule motor activity and ATPase activity, coupled. An important paralog of this gene is DYNLL2.

UniProtKB/Swiss-Prot: DNAL4_HUMAN, O96015
Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules.
Dynein has ATPase activity (By similarity)

Gene Wiki entry for DNAL4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAL4 gene promoter:
         SRF   AP-1   SRF (504 AA)   HNF-4alpha2   MIF-1   HNF-4alpha1   FOXL1   POU2F1   Ik-2   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAL4 promoter sequence
   Search Chromatin IP Primers for DNAL4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

DNAL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAL4 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M039174:  view genomic region     (about GC identifiers)

Start:
39,174,513 bp from pter      End:
39,190,203 bp from pter
Size:
15,691 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DNAL4_HUMAN, O96015 (See protein sequence)
Recommended Name: Dynein light chain 4, axonemal  
Size: 105 amino acids; 12009 Da
Subunit: Consists of at least two heavy chains and a number of intermediate and light chains
Secondary accessions: Q6FGB2 Q6FGD0

Explore the universe of human proteins at neXtProt for DNAL4: NX_O96015

Explore proteomics data for DNAL4 at MOPED


See DNAL4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_005731.1  
ENSEMBL proteins: 
 ENSP00000216068   ENSP00000385712  
Reactome Protein details: O96015

DNAL4 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
DN: Axonemal dyneins

1 InterPro protein domain:
 IPR001372 Dynein_light_chain_typ-1/2

Graphical View of Domain Structure for InterPro Entry O96015

ProtoNet protein and cluster: O96015

1 Blocks protein domain: IPB001372 Dynein light chain

UniProtKB/Swiss-Prot: DNAL4_HUMAN, O96015
Similarity: Belongs to the dynein light chain family


Find genes that share domains with DNAL4           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: DNAL4_HUMAN, O96015
Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules.
Dynein has ATPase activity (By similarity)

     Genatlas biochemistry entry for DNAL4:
dynein,axonemal,motor protein interacting with microtubules,light polypeptide 4,outer arm,essential for motility
of cilia and flagella,mouse ortholog

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003774motor activity IEA--
GO:0003777microtubule motor activity ----
GO:0042623ATPase activity, coupled ----
     
Find genes that share ontologies with DNAL4           About GenesLikeMe


Phenotypes:
     1 MGI phenotypic allele for Dnalc4 (no phenotypes)

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Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNAL4
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miRNA
Products:
    
miRTarBase miRNAs that target DNAL4:
hsa-mir-26b-5p (MIRT029200), hsa-mir-335-5p (MIRT017424)

Block miRNA regulation of human, mouse, rat DNAL4 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate DNAL4 (see all 13):
hsa-miR-548am hsa-miR-548d-3p hsa-miR-125a-5p hsa-miR-4328 hsa-miR-410 hsa-miR-548aa hsa-miR-3667-5p hsa-miR-661
SwitchGear 3'UTR luciferase reporter plasmidDNAL4 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat DNAL4

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAL4

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAL4


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
DNAL4_HUMAN, O96015: Cytoplasm, cytoskeleton, cilium axoneme (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytoskeleton5
plasma membrane4
cytosol3
extracellular2
mitochondrion1
nucleus1

Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IEA--
GO:0005858axonemal dynein complex ----
GO:0005874microtubule IEA--
GO:0005875microtubule associated complex ----
GO:0005886plasma membrane TAS--

Find genes that share ontologies with DNAL4           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for DNAL4 About    
See pathways by source

SuperPathContained pathways About
1Signaling by FGFR
NGF signalling via TRKA from the plasma membrane0.71
Signalling by NGF0.71
2Signaling by GPCR
Signal Transduction0.58
3Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Huntington's disease0.45
4Endocytic Trafficking of EGFR
Retrograde neurotrophin signalling0.36
5Cytoplasmic microtubules
Cytoplasmic microtubules0.32


Find genes that share SuperPaths with DNAL4           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



1 Reactome Pathway for DNAL4
    Retrograde neurotrophin signalling


1 Kegg Pathway  (Kegg details for DNAL4):
    Huntington's disease

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DNAL4
Interactions:

    Search GeneGlobe Interaction Network for DNAL4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for DNAL4 (O960152, 3 ENSP000002160684) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
InteractantInteraction Details
GeneCardExternal ID(s)
DYNLL2Q96FJ22, 3MINT-66259 I2D: score=4 
ENSG00000206378Q53GD33I2D: score=1 
ENSG00000228263Q53GD33I2D: score=1 
ENSG00000229077Q53GD33I2D: score=1 
ENSG00000231479Q53GD33I2D: score=1 
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007017microtubule-based process IEA--
GO:0007018microtubule-based movement ----
GO:0048011neurotrophin TRK receptor signaling pathway TAS--

Find genes that share ontologies with DNAL4           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DNAL4



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for DNAL4 gene: 
NM_005740.2  

Unigene Cluster for DNAL4:

Dynein, axonemal, light chain 4
Hs.632766  [show with all ESTs]
Unigene Representative Sequence: BM541924
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000216068(uc003awj.3) ENST00000486019 ENST00000406199 ENST00000475512

miRNA
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Selected qRT-PCR Assays for microRNAs that regulate DNAL4 (see all 13):
hsa-miR-548am hsa-miR-548d-3p hsa-miR-125a-5p hsa-miR-4328 hsa-miR-410 hsa-miR-548aa hsa-miR-3667-5p hsa-miR-661
SwitchGear 3'UTR luciferase reporter plasmidDNAL4 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for DNAL4
Predesigned siRNA for gene silencing in human, mouse, rat DNAL4
Clone
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: DNAL4 (NM_005740)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAL4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAL4
Primer
Products:
    
OriGene qPCR primer pairs and template standards for DNAL4
OriGene qSTAR qPCR primer pairs in human, mouse for DNAL4
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAL4
  QuantiTect SYBR Green Assays in human, mouse, rat DNAL4
  QuantiFast Probe-based Assays in human, mouse, rat DNAL4

Additional mRNA sequence: 

AK223349.1 AK290566.1 AL035366.1 AY453399.1 BC002968.1 BT009847.1 CR456487.1 CR542177.1 
CR542195.1 

12 DOTS entries:

DT.441761  DT.100023913  DT.100803592  DT.100803071  DT.95294741  DT.120664857  DT.120665003  DT.100023915 
DT.100791856  DT.100835432  DT.120664898  DT.120664951 

Selected AceView cDNA sequences (see all 181):

AW295655 BU727224 CR602893 AI084123 AI074275 AI261325 NM_005740 BM679539 
BM785991 AL035366 CA421248 AW298561 BQ934540 BX396248 AU105642 BX109838 
AW772377 BM721113 BM700827 BM665861 CR606519 CR542177 AA431647 N71273 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for DNAL4 (see all 6)    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1:                          -     -                 -                           
SP2:                                                  -                           
SP3:                          -     -                                             
SP4:                          -     -     -           -                           
SP5:                          -     -     -     -     -                           


ECgene alternative splicing isoforms for DNAL4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DNAL4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
DNAL4 Expression
About this image

DNAL4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DNAL4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.632766
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAL4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for DNAL4 gene from Selected species (see all 18)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Dnalc45
Dnal41
dynein, axonemal, light chain 41, 5 93.65(n)1
99.05(a)1
  15 (37.85 cM)5
541521  NM_017470.21  NP_059498.21 
 797614535 
chicken
(Gallus gallus)
Aves DNAL41 dynein, axonemal, light chain 4 83.83(n)
87.13(a)
  418019  NM_001006242.1  NP_001006242.1 
lizard
(Anolis carolinensis)
Reptilia DNAL46
dynein, axonemal, light chain 4
83(a)
1 ↔ 1
5(24278257-24283888)
African clawed frog
(Xenopus laevis)
Amphibia Xl.41202 Xenopus laevis transcribed sequence with moderate similarity more 79.94(n)    AW633470.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.143872 Transcribed sequence with moderate similarity to protein more 82.41(n)    BI672086.1 
fruit fly
(Drosophila melanogaster)
Insecta CG84071 CG8407 69.23(n)
59.62(a)
  36303  NM_001169653.2  NP_001163124.1 
worm
(Caenorhabditis elegans)
Secernentea dlc-56
Protein DLC-5 (dlc-5) mRNA, complete cds
15(a)
1 ↔ 1
IV(6438223-6440031) WBGene00043067
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DYN26
Cytoplasmic light chain dynein, microtubule motor ...
30(a)
1 → many
IV(1319387-1319841) YDR424C


ENSEMBL Gene Tree for DNAL4 (if available)
TreeFam Gene Tree for DNAL4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for DNAL4 gene
DYNLL22  DYNLL12  
3 SIMAP similar genes for DNAL4 using alignment to 2 protein entries:     DNAL4_HUMAN (see all proteins):
DNCL1    DYNLL1    DYNLL2

Find genes that share paralogs with DNAL4           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for DNAL4 (see all 399)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1164664851,2
C,F--39174068(+) CTCCTG/CCCAGA 1 -- ds50011Minor allele frequency- C:0.02WA 118
rs1389799231,2
C--39174079(+) ATGCCA/CCGCCC 1 -- ds50010--------
rs1415088331,2
--39174080(+) TGCCCC/TGCCCT 1 -- ds50010--------
rs1866317291,2
--39174140(+) TCTGCA/CGTGGA 1 -- ds50010--------
rs1922928961,2
--39174158(+) CTCACC/TGAGGC 1 -- ds50010--------
rs1172245781,2
C,F--39174247(+) TGAGTG/AAAATT 1 -- ds50011Minor allele frequency- A:0.06NA 120
rs666488351,2
C--39174307(+) TATCT-/CAGTGTC 1 -- ds50010--------
rs1507569771,2
C--39174388(+) GTCCAC/GTGGGG 1 -- ds50010--------
rs1390870151,2
--39174394(+) TGGGGC/TTATGC 1 -- ds50010--------
rs1494725211,2
--39174492(+) TAACAA/TCAAGA 1 -- ds50010--------

HapMap Linkage Disequilibrium report for DNAL4 (39174513 - 39190203 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for DNAL4:    About this table    
Variant IDTypeSubtypePubMed ID
nsv915067CNV Loss21882294
nsv915069CNV Loss21882294
nsv471199CNV Loss18288195
nsv915068CNV Loss21882294
dgv769n67CNV Gain20364138

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing DNAL4
DNA2.0 Custom Variant and Variant Library Synthesis for DNAL4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 610565    OMIM disorders: --


Find genes that share disorders with DNAL4           About GenesLikeMe


Export disorders for DNAL4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for DNAL4 gene, integrated from 10 sources (see all 14):
(articles sorted by number of sources associating them with DNAL4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I.... Wright H. (Nature 1999)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
  4. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PubMed id 12529303)1, 2 Collins J.E.... Dunham I. (Genome Res. 2003)
  5. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
  6. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
  7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
  8. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (Nature 2006)
  9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
  10. Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model. (PubMed id 15454493)1 Iwasaki M....Nakamura T. (Blood 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10126 HGNC: 2955 AceView: DNAL4 Ensembl:ENSG00000100246 euGenes: HUgn10126
ECgene: DNAL4 Kegg: 10126 H-InvDB: DNAL4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for DNAL4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for DNAL4 gene:
Search GeneIP for patents involving DNAL4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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