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DNAL1 Gene

protein-coding   GIFtS: 58
GCID: GC14P074111

Dynein, Axonemal, Light Chain 1

(Previous name: chromosome 14 open reading frame 168)
(Previous symbol: C14orf168)
  See DNAL1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dynein, Axonemal, Light Chain 11 2
C14orf1681 2 3 5
CILD162 5
Chromosome 14 Open Reading Frame 1681
Dynein Light Chain 1, Axonemal2

External Ids:    HGNC: 232471   Entrez Gene: 835442   Ensembl: ENSG000001196617   OMIM: 6100625   UniProtKB: Q4LDG93   

Export aliases for DNAL1 gene to outside databases

Previous GC identifers: GC14P073183 GC14P054279


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNAL1 Gene:
This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex.
This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The
encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of
sperm flagella. Alternate splicing results in multiple transcript variants.(provided by RefSeq, Jan 2011)

GeneCards Summary for DNAL1 Gene:
DNAL1 (dynein, axonemal, light chain 1) is a protein-coding gene. Diseases associated with DNAL1 include ciliary dyskinesia, primary, 16, and primary ciliary dyskinesia16: dnal1-related primary ciliary dyskinesia.

Gene Wiki entry for DNAL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAL1 gene promoter:
         RFX1   Pbx1a   AML1a   FOXO3   CUTL1   FOXO3b   FOXO4   FOXO3a   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAL1 promoter sequence
   Search Chromatin IP Primers for DNAL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

DNAL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAL1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P074111:  view genomic region     (about GC identifiers)

Start:
74,111,578 bp from pter      End:
74,170,435 bp from pter
Size:
58,858 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DNAL1_HUMAN, Q4LDG9 (See protein sequence)
Recommended Name: Dynein light chain 1, axonemal  
Size: 190 amino acids; 21533 Da
Subunit: Interacts with DNAH5
Sequence caution: Sequence=AAH05343.1; Type=Erroneous initiation;
Secondary accessions: B2RD38 Q5JPB7 Q9BS43
Alternative splicing: 3 isoforms:  Q4LDG9-1   Q4LDG9-2   Q4LDG9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DNAL1: NX_Q4LDG9

Explore proteomics data for DNAL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DNAL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001188295.1  NP_113615.2  

    ENSEMBL proteins: 
     ENSP00000452368   ENSP00000451547   ENSP00000452037   ENSP00000310360   ENSP00000451101  
     ENSP00000450744   ENSP00000451834   ENSP00000453439   ENSP00000451264   ENSP00000439695  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001611 Leu-rich_rpt

    Graphical View of Domain Structure for InterPro Entry Q4LDG9

    ProtoNet protein and cluster: Q4LDG9

    UniProtKB/Swiss-Prot: DNAL1_HUMAN, Q4LDG9
    Similarity: Belongs to the dynein light chain LC1-type family
    Similarity: Contains 4 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain


    Find genes that share domains with DNAL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for DNAL1:
    dynein,axonemal,motor protein interacting with microtubules,light chain 1,inner arm,of unknown function,essential
    for motility of cilia and flagella,expressed in testis

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with DNAL1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DNAL1:
     Decreased Tat-dependent transc  Decreased p24 protein expressi 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNAL1
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    miRNA
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    miRTarBase miRNAs that target DNAL1:
    hsa-mir-192-5p (MIRT026555), hsa-mir-324-5p (MIRT043060)

    Block miRNA regulation of human, mouse, rat DNAL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAL1 (see all 156):
    hsa-miR-576-3p hsa-miR-26a-2* hsa-miR-106a hsa-miR-146a hsa-miR-3653 hsa-miR-519a hsa-miR-4326 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidDNAL1 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat DNAL1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    plasma membrane2
    cytoskeleton1
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DNAL1 About    
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Huntington's disease0.45
    2Cytoplasmic microtubules
    Cytoplasmic microtubules0.32


    Find genes that share SuperPaths with DNAL1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for DNAL1):
        Huntington's disease

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DNAL1
    Interactions:

        Search GeneGlobe Interaction Network for DNAL1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNAL1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DNAL1 gene (2 alternative transcripts): 
    NM_001201366.1  NM_031427.3  

    Unigene Cluster for DNAL1:

    Dynein, axonemal, light chain 1
    Hs.271270  [show with all ESTs]
    Unigene Representative Sequence: NM_001201366
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000554113 ENST00000555631 ENST00000553645 ENST00000311089(uc010aru.3 uc001xoq.4 uc010arv.3)
    ENST00000555919 ENST00000554339 ENST00000554871 ENST00000559993 ENST00000554159
    ENST00000540526
    miRNA
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    Block miRNA regulation of human, mouse, rat DNAL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAL1 (see all 156):
    hsa-miR-576-3p hsa-miR-26a-2* hsa-miR-106a hsa-miR-146a hsa-miR-3653 hsa-miR-519a hsa-miR-4326 hsa-miR-130b
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    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAL1
    Primer
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    OriGene qPCR primer pairs and template standards for DNAL1
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAL1
      QuantiTect SYBR Green Assays in human, mouse, rat DNAL1
      QuantiFast Probe-based Assays in human, mouse, rat DNAL1

    Additional mRNA sequence: 

    AF542071.1 AK315392.1 BC005343.1 

    12 DOTS entries:

    DT.116642  DT.99937365  DT.403536  DT.201645  DT.75161901  DT.120770735  DT.40207913  DT.120770727 
    DT.455760  DT.92418501  DT.92418502  DT.99999127 

    Selected AceView cDNA sequences (see all 170):

    AI538696 BF475818 BE835496 BE467862 Z45540 BX112638 AA677030 AA975229 
    F05801 AW080421 AI283479 AI242197 AI052620 BU950957 CA943186 AI016435 
    CA430714 BF433533 BE503267 CA307053 CB218818 CA453564 AI123048 CA406460 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNAL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTTTATGAC
    DNAL1 Expression
    About this image


    DNAL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    DNAL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.271270

    UniProtKB/Swiss-Prot: DNAL1_HUMAN, Q4LDG9
    Tissue specificity: Expressed in tissues carrying motile cilia such as testis

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DNAL1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnalc15
    Dnal11
    dynein, axonemal, light chain 11, 5 88.6(n)1
    93.16(a)1
      12 (39.05 cM)5
    1050001  NM_028821.31  NP_083097.21 
     841143665 
    chicken
    (Gallus gallus)
    Aves DNAL11 dynein, axonemal, light chain 1 80.6(n)
    84.66(a)
      423246  NM_001199681.1  NP_001186610.1 
    lizard
    (Anolis carolinensis)
    Reptilia DNAL16
    dynein, axonemal, light chain 1
    88(a)
    1 ↔ 1
    1(39229405-39244102)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dnal11 dynein, axonemal, light chain 1 74.91(n)
    85.26(a)
      549066  NM_001016312.2  NP_001016312.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dnal11 dynein, axonemal, light chain 1 73.37(n)
    82.54(a)
      445048  NM_001003442.1  NP_001003442.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG88001 CG8800 55.61(n)
    58.82(a)
      35962  NM_136639.2  NP_610483.1 


    ENSEMBL Gene Tree for DNAL1 (if available)
    TreeFam Gene Tree for DNAL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNAL1 gene
    3 SIMAP similar genes for DNAL1 using alignment to 7 protein entries:     DNAL1_HUMAN (see all proteins):
    PPP1R7    NISCH    LRRC49

    Find genes that share paralogs with DNAL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNAL1 (see all 1380)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0657394
    Ciliary dyskinesia, primary, 16 (CILD16)4--see VAR_0657392 N S mis40--------
    rs2010914921,2
    C--54281789(+) TCAAA-/AAAAAA
    AAAAAAAAG
    AAAAA
    2 -- int10--------
    rs801283611,2
    C--54281794(+) AAAAAA/GAAAAA 2 -- int10--------
    rs2008466361,2
    C--54281818(+) AAGAA-/AAAG  
            
    AAATA
    2 -- int10--------
    rs2012226511,2
    C--54285587(+) CTAAT-/TTTTTT 2 -- int10--------
    rs1122332041,2
    C--54299314(+) TGTCT-/AAAAAA 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs114039981,2
    C--54308341(+) AGGGGA/-AAAAA 2 -- int1 trp31Minor allele frequency- -:0.00CSA 2
    rs796922471,2
    C--54310906(+) TATATG/ATGTGT 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs568792771,2
    C--54311439(+) TTTTT-/A/TAATTG 2 -- int10--------
    rs784329881,2
    C--54311439(+) TTTTTA/TAATTG 2 -- int12Minor allele frequency- T:0.25NA 4

    HapMap Linkage Disequilibrium report for DNAL1 (74111578 - 74170435 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for DNAL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv902089CNV Loss21882294
    dgv1959n71CNV Loss21882294
    nsv902091CNV Gain21882294
    nsv428295CNV Gain18775914
    nsv832828CNV Gain+Loss17160897
    dgv641e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): DNAL1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAL1
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610062   
    OMIM disorders: 614017  
    UniProtKB/Swiss-Prot: DNAL1_HUMAN, Q4LDG9
  • Ciliary dyskinesia, primary, 16 (CILD16) [MIM:614017]: A disorder characterized by abnormalities of
    motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to
    defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of
    sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to
    dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is
    referred to as Kartagener syndrome. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • 4 diseases for DNAL1:    
    About MalaCards
    ciliary dyskinesia, primary, 16    primary ciliary dyskinesia16: dnal1-related primary ciliary dyskinesia    craniofacial anomalies and anterior segment dysgenesis syndrome    ciliary dyskinesia, primary, 19

    1 disease from the University of Copenhagen DISEASES database for DNAL1:
    Primary ciliary dyskinesia

    Find genes that share disorders with DNAL1           About GenesLikeMe

    Genetic Association Database (GAD): DNAL1
    Human Genome Epidemiology (HuGE) Navigator: DNAL1 (2 documents)

    Export disorders for DNAL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNAL1 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with DNAL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients. (PubMed id 15845866)1, 2, 3, 9 Horvath J.... Omran H. (Am. J. Respir. Cell Mol. Biol. 2005)
    2. Primary ciliary dyskinesia caused by homozygous mutation in DNAL1, encoding dynein light chain 1. (PubMed id 21496787)1, 2 Mazor M.... Parvari R. (Am. J. Hum. Genet. 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Knockdown of MAP4 and DNAL1 produces a post-fusion and pre-nuclear translocation impairment in HIV-1 replication. (PubMed id 22018492)1 Gallo D.E. and Hope T.J. (Virology 2012)
    7. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (J. Infect. Dis. 2010)
    9. Identification of host proteins required for HIV infection through a functional genomic screen. (PubMed id 18187620)1 Brass A.L....Elledge S.J. (Science 2008)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83544 HGNC: 23247 AceView: C14orf168 Ensembl:ENSG00000119661 euGenes: HUgn83544
    ECgene: DNAL1 Kegg: 83544 H-InvDB: DNAL1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DNAL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNAL1 gene:
    Search GeneIP for patents involving DNAL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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