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Aliases for DNAJC9 Gene

Aliases for DNAJC9 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C9 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 9 2 3
  • DnaJ Protein SB73 3 4
  • HDJC9 3 4
  • DnaJ Homolog Subfamily C Member 9 3
  • JDD1 3
  • SB73 3

External Ids for DNAJC9 Gene

Previous GeneCards Identifiers for DNAJC9 Gene

  • GC10P073706
  • GC10P074031
  • GC10M074836
  • GC10M074348
  • GC10M074350
  • GC10M074673
  • GC10M074676
  • GC10M074943
  • GC10M068996

Summaries for DNAJC9 Gene

GeneCards Summary for DNAJC9 Gene

DNAJC9 (DnaJ Heat Shock Protein Family (Hsp40) Member C9) is a Protein Coding gene. Diseases associated with DNAJC9 include Recurrent Corneal Erosion and Cervical Squamous Cell Carcinoma.

UniProtKB/Swiss-Prot for DNAJC9 Gene

  • May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8.

Additional gene information for DNAJC9 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC9 Gene

Genomics for DNAJC9 Gene

Regulatory Elements for DNAJC9 Gene

Enhancers for DNAJC9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H073964 2.4 VISTA FANTOM5 Ensembl ENCODE dbSUPER 15 -718.3 -718338 6 PKNOX1 SIN3A FEZF1 ZNF2 ETS1 GTF3C2 GLIS2 ATF7 FOS SP3 SEC24C GLUD1P3 ENSG00000272140 DUSP8P5 BMS1P4 AP3M1 ENSG00000242288 ECD ZSWIM8 RPL17P50
GH10H072270 1.5 ENCODE dbSUPER 23.5 +974.1 974096 8 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A PPARGC1A ECD DNAJB12 ENSG00000227540 FAM149B1 RPL17P50 DNAJC9 ENSG00000272630 ASCC1 HMGN2P34 CDH23-AS1
GH10H072326 2.1 FANTOM5 Ensembl ENCODE dbSUPER 14 +916.6 916615 11 HDGF FOXA2 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B DNAJB12 ENSG00000227540 HMGN2P34 CDH23-AS1 DNAJC9 ECD ENSG00000272599 DDIT4 PSAP P4HA1
GH10H072241 2.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 12.5 +999.1 999062 16 MLX DMAP1 YBX1 YY1 ZNF143 SP3 ZC3H11A MEF2D SSRP1 ZNF610 ECD DNAJB12 RPL17P50 ENSG00000272599 ASCC1 DDIT4 CHST3 DNAJC9 ENSG00000200170 ANAPC16
GH10H073905 2 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -661.8 -661764 10 PKNOX1 ARNT SIN3A ZNF766 ZNF143 FOS SP3 JUNB REST SMARCB1 DNAJC9 ECD CAMK2G ENSG00000229990 VCL KAT6B ENSG00000272630 FUT11 ENSG00000272791 NDST2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DNAJC9 on UCSC Golden Path with GeneCards custom track

Genomic Location for DNAJC9 Gene

Chromosome:
10
Start:
73,183,362 bp from pter
End:
73,248,862 bp from pter
Size:
65,501 bases
Orientation:
Minus strand

Genomic View for DNAJC9 Gene

Genes around DNAJC9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC9 Gene

Proteins for DNAJC9 Gene

  • Protein details for DNAJC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXX5-DNJC9_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 9
    Protein Accession:
    Q8WXX5
    Secondary Accessions:
    • B2RMW6

    Protein attributes for DNAJC9 Gene

    Size:
    260 amino acids
    Molecular mass:
    29910 Da
    Quaternary structure:
    • Interacts (via J domain) with HSPA1A, HSPA1B and HSPA8.

neXtProt entry for DNAJC9 Gene

Post-translational modifications for DNAJC9 Gene

  • Ubiquitination at posLast=217217
  • Modification sites at PhosphoSitePlus

Other Protein References for DNAJC9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJC9 Gene

Domains & Families for DNAJC9 Gene

Gene Families for DNAJC9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DNAJC9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DNAJC9 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNAJC9: view

No data available for UniProtKB/Swiss-Prot for DNAJC9 Gene

Function for DNAJC9 Gene

Molecular function for DNAJC9 Gene

UniProtKB/Swiss-Prot Function:
May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8.
UniProtKB/Swiss-Prot Induction:
By heat shock, bacterial lipopolysaccharides (LPS), phorbol 12-myristate 13-acetate (PMA), and the cytokine TNF (at protein level).

Phenotypes From GWAS Catalog for DNAJC9 Gene

Gene Ontology (GO) - Molecular Function for DNAJC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031072 heat shock protein binding IPI 17182002
genes like me logo Genes that share ontologies with DNAJC9: view

Phenotypes for DNAJC9 Gene

genes like me logo Genes that share phenotypes with DNAJC9: view

Animal Models for DNAJC9 Gene

MGI Knock Outs for DNAJC9:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DNAJC9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DNAJC9 Gene

Localization for DNAJC9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC9 Gene

Nucleus. Cytoplasm. Cell membrane. Note=Predominantly nuclear. Translocates to the cytoplasm and membrane after heat shock. {ECO:0000269 PubMed:17182002}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJC9 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DNAJC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 17182002
GO:0005634 nucleus IDA,IEA 17182002
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IEA 17182002
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with DNAJC9: view

Pathways & Interactions for DNAJC9 Gene

SuperPathways for DNAJC9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032781 positive regulation of ATPase activity IDA 17182002
GO:0035176 social behavior IEP 21531385
genes like me logo Genes that share ontologies with DNAJC9: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJC9 Gene

Drugs & Compounds for DNAJC9 Gene

No Compound Related Data Available

Transcripts for DNAJC9 Gene

Unigene Clusters for DNAJC9 Gene

DnaJ (Hsp40) homolog, subfamily C, member 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DNAJC9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC9 Gene

No ASD Table

Relevant External Links for DNAJC9 Gene

GeneLoc Exon Structure for
DNAJC9
ECgene alternative splicing isoforms for
DNAJC9

Expression for DNAJC9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJC9 Gene

Protein differential expression in normal tissues from HIPED for DNAJC9 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNAJC9 Gene



Protein tissue co-expression partners for DNAJC9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJC9 Gene:

DNAJC9

SOURCE GeneReport for Unigene cluster for DNAJC9 Gene:

Hs.732485

mRNA Expression by UniProt/SwissProt for DNAJC9 Gene:

Q8WXX5-DNJC9_HUMAN
Tissue specificity: Expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, thymus, ovary, colon and peripheral blood.

Evidence on tissue expression from TISSUES for DNAJC9 Gene

  • Nervous system(4.6)
  • Liver(4.3)
  • Blood(2.4)
genes like me logo Genes that share expression patterns with DNAJC9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJC9 Gene

Orthologs for DNAJC9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJC9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC9 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAJC9 33 34
  • 90.93 (n)
dog
(Canis familiaris)
Mammalia DNAJC9 33 34
  • 89.56 (n)
mouse
(Mus musculus)
Mammalia Dnajc9 33 16 34
  • 86.83 (n)
rat
(Rattus norvegicus)
Mammalia Dnajc9 33
  • 86.28 (n)
oppossum
(Monodelphis domestica)
Mammalia DNAJC9 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC9 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJC9 33 34
  • 71.49 (n)
lizard
(Anolis carolinensis)
Reptilia DNAJC9 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc9 33
  • 67.22 (n)
MGC76175 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24030 33
zebrafish
(Danio rerio)
Actinopterygii dnajc9 33 34
  • 61.11 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3259 33
fruit fly
(Drosophila melanogaster)
Insecta CG6693 33 34
  • 52.42 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004849 33
  • 51.36 (n)
worm
(Caenorhabditis elegans)
Secernentea dnj-23 33 34
  • 47.66 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G12170 33
  • 48.86 (n)
rice
(Oryza sativa)
Liliopsida Os02g0195800 33
  • 45.22 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1071.09c 33
  • 49.47 (n)
Species where no ortholog for DNAJC9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC9 Gene

ENSEMBL:
Gene Tree for DNAJC9 (if available)
TreeFam:
Gene Tree for DNAJC9 (if available)

Paralogs for DNAJC9 Gene

Pseudogenes.org Pseudogenes for DNAJC9 Gene

genes like me logo Genes that share paralogs with DNAJC9: view

No data available for Paralogs for DNAJC9 Gene

Variants for DNAJC9 Gene

Sequence variations from dbSNP and Humsavar for DNAJC9 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs886047186 Uncertain significance 73,248,992(-) GCAGT(G/T)AACTG intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs886047187 Uncertain significance 73,249,091(-) AACTT(A/G)AAAAA intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000131840 -- 73,248,891(+) TTCAA(A/G)AACCA intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000168196 -- 73,244,053(+) TGAAT(C/T)GAATT intron-variant
rs1000231874 -- 73,248,522(+) AGCCA(C/T)CTGTC intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DNAJC9 Gene

Variant ID Type Subtype PubMed ID
nsv948066 CNV duplication 23825009

Variation tolerance for DNAJC9 Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC9 Gene

Human Gene Mutation Database (HGMD)
DNAJC9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJC9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC9 Gene

Disorders for DNAJC9 Gene

MalaCards: The human disease database

(3) MalaCards diseases for DNAJC9 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
recurrent corneal erosion
  • recurrent erosion of cornea
cervical squamous cell carcinoma
  • squamous cell carcinoma of cervix
corneal degeneration
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DNAJC9

Genetic Association Database (GAD)
DNAJC9
Human Genome Epidemiology (HuGE) Navigator
DNAJC9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJC9
genes like me logo Genes that share disorders with DNAJC9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNAJC9 Gene

Publications for DNAJC9 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. HDJC9, a novel human type C DnaJ/HSP40 member interacts with and cochaperones HSP70 through the J domain. (PMID: 17182002) Han C … Cao X (Biochemical and biophysical research communications 2007) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for DNAJC9 Gene

Sources for DNAJC9 Gene

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