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Aliases for DNAJC9 Gene

Aliases for DNAJC9 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C9 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 9 2 3
  • DnaJ Protein SB73 3 4
  • HDJC9 3 4
  • JDD1 3
  • SB73 3

External Ids for DNAJC9 Gene

Previous GeneCards Identifiers for DNAJC9 Gene

  • GC10P073706
  • GC10P074031
  • GC10M074836
  • GC10M074348
  • GC10M074350
  • GC10M074673
  • GC10M074676
  • GC10M074943
  • GC10M068996

Summaries for DNAJC9 Gene

GeneCards Summary for DNAJC9 Gene

DNAJC9 (DnaJ Heat Shock Protein Family (Hsp40) Member C9) is a Protein Coding gene. Diseases associated with DNAJC9 include cervical squamous cell carcinoma.

UniProtKB/Swiss-Prot for DNAJC9 Gene

  • May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC9 Gene

Genomics for DNAJC9 Gene

Regulatory Elements for DNAJC9 Gene

Genomic Location for DNAJC9 Gene

Chromosome:
10
Start:
73,183,362 bp from pter
End:
73,248,862 bp from pter
Size:
65,501 bases
Orientation:
Minus strand

Genomic View for DNAJC9 Gene

Genes around DNAJC9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC9 Gene

Proteins for DNAJC9 Gene

  • Protein details for DNAJC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXX5-DNJC9_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 9
    Protein Accession:
    Q8WXX5
    Secondary Accessions:
    • B2RMW6

    Protein attributes for DNAJC9 Gene

    Size:
    260 amino acids
    Molecular mass:
    29910 Da
    Quaternary structure:
    • Interacts (via J domain) with HSPA1A, HSPA1B and HSPA8.

neXtProt entry for DNAJC9 Gene

Proteomics data for DNAJC9 Gene at MOPED

Post-translational modifications for DNAJC9 Gene

  • Ubiquitination at Lys 217
  • Modification sites at PhosphoSitePlus

Other Protein References for DNAJC9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJC9 Gene

Domains & Families for DNAJC9 Gene

Gene Families for DNAJC9 Gene

Protein Domains for DNAJC9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DNAJC9 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WXX5

UniProtKB/Swiss-Prot:

DNJC9_HUMAN :
  • Contains 1 J domain.
Domain:
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJC9: view

Function for DNAJC9 Gene

Molecular function for DNAJC9 Gene

UniProtKB/Swiss-Prot Function:
May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8.
UniProtKB/Swiss-Prot Induction:
By heat shock, bacterial lipopolysaccharides (LPS), phorbol 12-myristate 13-acetate (PMA), and the cytokine TNF (at protein level).

Phenotypes for DNAJC9 Gene

genes like me logo Genes that share phenotypes with DNAJC9: view

Animal Models for DNAJC9 Gene

MGI Knock Outs for DNAJC9:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DNAJC9 Gene

Localization for DNAJC9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC9 Gene

Nucleus. Cytoplasm. Cell membrane. Note=Predominantly nuclear. Translocates to the cytoplasm and membrane after heat shock. {ECO:0000269 PubMed:17182002}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJC9 Gene COMPARTMENTS Subcellular localization image for DNAJC9 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 5
cytosol 4

Gene Ontology (GO) - Cellular Components for DNAJC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17182002
genes like me logo Genes that share ontologies with DNAJC9: view

Pathways & Interactions for DNAJC9 Gene

SuperPathways for DNAJC9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJC9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DNAJC9 Gene

Drugs & Compounds for DNAJC9 Gene

No Compound Related Data Available

Transcripts for DNAJC9 Gene

Unigene Clusters for DNAJC9 Gene

DnaJ (Hsp40) homolog, subfamily C, member 9:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC9 Gene

No ASD Table

Relevant External Links for DNAJC9 Gene

GeneLoc Exon Structure for
DNAJC9
ECgene alternative splicing isoforms for
DNAJC9

Expression for DNAJC9 Gene

mRNA expression in normal human tissues for DNAJC9 Gene

Protein differential expression in normal tissues from HIPED for DNAJC9 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJC9 Gene



SOURCE GeneReport for Unigene cluster for DNAJC9 Gene Hs.732485

mRNA Expression by UniProt/SwissProt for DNAJC9 Gene

Q8WXX5-DNJC9_HUMAN
Tissue specificity: Expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, thymus, ovary, colon and peripheral blood.
genes like me logo Genes that share expression patterns with DNAJC9: view

Protein tissue co-expression partners for DNAJC9 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DNAJC9 Gene

Orthologs for DNAJC9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJC9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC9 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAJC9 36
  • 93 (a)
OneToOne
DNAJC9 35
  • 90.93 (n)
  • 94 (a)
dog
(Canis familiaris)
Mammalia DNAJC9 35
  • 89.56 (n)
  • 93.57 (a)
DNAJC9 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajc9 16
Dnajc9 36
  • 88 (a)
OneToOne
Dnajc9 35
  • 86.83 (n)
  • 88.48 (a)
oppossum
(Monodelphis domestica)
Mammalia DNAJC9 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC9 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajc9 35
  • 86.28 (n)
  • 90.53 (a)
chicken
(Gallus gallus)
Aves DNAJC9 35
  • 71.49 (n)
  • 73.14 (a)
DNAJC9 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJC9 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24030 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc9 35
  • 67.22 (n)
  • 66.12 (a)
MGC76175 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3259 35
zebrafish
(Danio rerio)
Actinopterygii dnajc9 35
  • 61.11 (n)
  • 60.83 (a)
dnajc9 36
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004849 35
  • 51.36 (n)
  • 42.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6693 35
  • 52.42 (n)
  • 40.25 (a)
CG6693 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dnj-23 36
  • 37 (a)
OneToOne
dnj-23 35
  • 47.66 (n)
  • 38.16 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G12170 35
  • 48.86 (n)
  • 42.65 (a)
rice
(Oryza sativa)
Liliopsida Os02g0195800 35
  • 45.22 (n)
  • 37.96 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1071.09c 35
  • 49.47 (n)
  • 42.92 (a)
Species with no ortholog for DNAJC9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC9 Gene

ENSEMBL:
Gene Tree for DNAJC9 (if available)
TreeFam:
Gene Tree for DNAJC9 (if available)

Paralogs for DNAJC9 Gene

Pseudogenes.org Pseudogenes for DNAJC9 Gene

genes like me logo Genes that share paralogs with DNAJC9: view

No data available for Paralogs for DNAJC9 Gene

Variants for DNAJC9 Gene

Sequence variations from dbSNP and Humsavar for DNAJC9 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs12250119 -- 73,245,317(+) ACGCC(C/T)GATGA intron-variant
rs12244262 -- 73,243,043(+) CTATT(C/T)TAACA utr-variant-3-prime
rs12780866 -- 73,243,106(+) TTCTG(G/T)GTACA utr-variant-3-prime
rs61758428 -- 73,243,409(+) TTCTT(C/T)TCTTT reference, synonymous-codon
rs80251151 -- 73,245,345(+) AACCA(C/G)CCCCC intron-variant

Variation tolerance for DNAJC9 Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC9 Gene

HapMap Linkage Disequilibrium report
DNAJC9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DNAJC9 Gene

Disorders for DNAJC9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DNAJC9 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cervical squamous cell carcinoma
  • squamous cell carcinoma of cervix
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DNAJC9

Genetic Association Database (GAD)
DNAJC9
Human Genome Epidemiology (HuGE) Navigator
DNAJC9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJC9
genes like me logo Genes that share disorders with DNAJC9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNAJC9 Gene

Publications for DNAJC9 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. (PMID: 24332808) Marechal A. … Zou L. (Mol. Cell 2014) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for DNAJC9 Gene

Sources for DNAJC9 Gene

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