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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DNAJC9 Gene

protein-coding   GIFtS: 46
GCID: GC10M074943

DnaJ (Hsp40) homolog, subfamily C, member 9

 Explore 7 diseases affiliated with
DNAJC9 via our new
 Human Malady Compendium 
Biological research products
for DNAJC9
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
DnaJ (Hsp40) Homolog, Subfamily C, Member 91 2     HDJC92
JDD11 2 5     DnaJ Homolog Subfamily C Member 92
SB731 2     KIAA09745
DnaJ Protein SB732 3     

External Ids:    HGNC: 191231   Entrez Gene: 232342   Ensembl: ENSG000002135517   OMIM: 6112065   UniProtKB: Q8WXX53   

Export aliases for DNAJC9 gene to outside databases

Previous GC identifers: GC10P073706 GC10P074031 GC10M074836 GC10M074348 GC10M074350 GC10M074673 GC10M074676 GC10M068996


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DNAJC9 gene promoter:
         AhR   Pbx1a   AML1a   STAT5A   CUTL1   Nkx2-5   Arnt   AREB6   NRF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for DNAJC9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJC9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.2   Ensembl cytogenetic band:  10q22.2   HGNC cytogenetic band: 10q22.3

DNAJC9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJC9 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M074943:  view genomic region     (about GC identifiers)

Start:
74,943,120 bp from pter      End:
75,008,620 bp from pter
Size:
65,501 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DNJC9_HUMAN, Q8WXX5 (See protein sequence)
Recommended Name: DnaJ homolog subfamily C member 9  
Size: 260 amino acids; 29910 Da

Explore the universe of human proteins at neXtProt for DNAJC9: NX_Q8WXX5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WXX5

  • DNAJC9 Protein expression data from MOPED and PaxDb:    About this image 
    DNAJC9 Protein Expression
    REFSEQ proteins: NP_056005.1  
    ENSEMBL proteins: 
     ENSP00000362041  

    Human Recombinant Protein Products for DNAJC9: 
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    Uscn Proteins for DNAJC9


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    Uscn ELISAs and CLIAs for DNAJC9


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    DNAJC9 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001623 DnaJ_domain
     IPR018253 DnaJ_domain_CS

    Graphical View of Domain Structure for InterPro Entry Q8WXX5

    ProtoNet protein and cluster: Q8WXX5

    UniProtKB/Swiss-Prot: DNJC9_HUMAN, Q8WXX5
    Similarity: Contains 1 J domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031072heat shock protein binding IEA--
    GO:0051082unfolded protein binding IEA--
         
    DNAJC9 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DNAJC9 

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    hsa-miR-520e hsa-miR-302d hsa-miR-520d-5p hsa-miR-302a hsa-miR-302e hsa-miR-373 hsa-miR-520a-3p hsa-miR-520c-3p
    SwitchGear 3'UTR luciferase reporter plasmidDNAJC9 3' UTR sequence
    Inhib. RNA
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC9


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNAJC9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/35 Interacting proteins for DNAJC9 (Q8WXX53 ENSP000003620414) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0035176social behavior IEP--

    DNAJC9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DNAJC9
    Search CenterWatch for drugs/clinical trials and news about DNAJC9 / DNJC9 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DNAJC9 gene: 
    NM_015190.3  

    Unigene Cluster for DNAJC9:

    DnaJ (Hsp40) homolog, subfamily C, member 9
    Hs.732485  [show with all ESTs]
    Unigene Representative Sequence: AK094162
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469143 ENST00000372950(uc001jtr.3 uc010qkg.2)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DNAJC9
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate DNAJC9 (see all 14):
    hsa-miR-520e hsa-miR-302d hsa-miR-520d-5p hsa-miR-302a hsa-miR-302e hsa-miR-373 hsa-miR-520a-3p hsa-miR-520c-3p
    SwitchGear 3'UTR luciferase reporter plasmidDNAJC9 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNAJC9 (see all 6)
    Browse OriGene siRNA
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    Sirion Biotech Custom design and validation of potent shRNA sequences against DNAJC9 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC9 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC9
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC9 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAJC9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAJC9

    Additional cDNA sequence: 

    AF327347.1 AK074420.1 AK094162.1 AK303204.1 BC136507.1 

    8 DOTS entries:

    DT.100650604  DT.95265511  DT.75136646  DT.451865  DT.101984294  DT.40222757  DT.100045726  DT.215836 

    24/445 AceView cDNA sequences (see all 445):

    BQ690887 BM789217 BG818234 BM999982 AI251857 AA729412 BM768744 BM472254 
    AI203347 BG028612 BX448626 BF063763 AI804168 BE327444 AI567862 BX646217 
    AA602701 AI160900 AA581180 AI091910 BQ007526 AA746286 BQ954888 AA194114 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DNAJC9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGCTTTCTG
    DNAJC9 Expression
    About this image
    See DNAJC9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DNAJC9

    SOURCE GeneReport for Unigene cluster: Hs.732485
        SABiosciences Expression via Pathway-Focused PCR Arrays including DNAJC9: 

              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNAJC9 gene from 9/30 species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnajc91 , 5 DnaJ (Hsp40) homolog, subfamily C, member 91, 5 86.87(n)1
    88.03(a)1
      14 (11.53 cM)5
    1086711  NM_134081.51  NP_598842.11 
     203846385 
    chicken
    (Gallus gallus)
    Aves DNAJC91 DnaJ (Hsp40) homolog, subfamily C, member 9 71.03(n)
    71.92(a)
      423640  NM_001199525.1  NP_001186454.1 
    lizard
    (Anolis carolinensis)
    Reptilia DNAJC96
    --
    72(a)
    1 ↔ 1
    GL343378.1(36621-45712)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.240302 Xenopus laevis transcribed sequence with weak similarity more 70.11(n)    CA793189.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dnajc91 DnaJ (Hsp40) homolog, subfamily C, member 9 60.75(n)
    60.08(a)
      436706  NM_001002433.1  NP_001002433.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG66931 CG6693 51.03(n)
    38.46(a)
      41346  NM_141795.3  NP_650052.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dnj-231 Protein DNJ-23 47.03(n)
    38.14(a)
      174451  NM_063543.4  NP_495944.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G121701 chaperone DnaJ-domain containing protein 48.07(n)
    41.2(a)
      820394  NM_112052.2  NP_187824.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g01958001 hypothetical protein 45.54(n)
    38.5(a)
      4328611  NM_001052723.1  NP_001046188.1 


    ENSEMBL Gene Tree for DNAJC9 (if available)
    TreeFam Gene Tree for DNAJC9 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DNAJC9 gene

    DNAJC9 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for DNAJC9
    PGOHUM00000248211 PGOHUM00000247442


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/141 NCBI SNPs in DNAJC9 are shown (see all 141    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10548581,2
    A--69002815(-) ctcacA/Gcctgt 1 -- ut313Minor allele frequency- G:0.00MN NA 188
    rs1378752091,2
    C--75002172(+) AAGTT-/AAAGAAT 2 -- int10--------
    rs2020012151,2
    --75002176(+) TAAAG-/AATCAGA 2 -- int10--------
    rs1136612951,2
    C--75002177(+) AAAGAG/ATCAGA 2 -- int11Minor allele frequency- A:0.00CSA 1
    rs1398982731,2
    --75002276(+) CTGGAC/TATGTT 2 -- int10--------
    rs122440471,2
    F,A--75002279(+) GACATG/ATTTAA 2 -- int13Minor allele frequency- A:0.18WA NA EA 358
    rs1461525201,2
    C--75002317(+) CACTC-/TTTGTT 2 -- int10--------
    rs1897882951,2
    --75002330(+) GATGTA/CGTAAC 2 -- int10--------
    rs1810260971,2
    --75002436(+) TACAAC/TATACA 2 -- int10--------
    rs1854989571,2
    --75002464(+) AACCAA/GGCTCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for DNAJC9 (74943120 - 75008620 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DNAJC9: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DNAJC9 for disorders           About GeneDecksing

    OMIM gene information: 611206    OMIM disorders: --

    7 diseases for DNAJC9:    About MalaCards
    metastasis efficiency    cervical squamous cell carcinoma    squamous cell carcinoma    cervicitis
    carcinoma    schizophrenia    malaria

    1 disease from the University of Copenhagen DISEASES database for DNAJC9:
    Cervical squamous cell carcinoma
    Human Genome Epidemiology (HuGE) Navigator: DNAJC9 (1 document)

    Export disorders for DNAJC9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DNAJC9 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with DNAJC9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    3. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosom e 10q22 associated with the subgroup of schizophrenia with deficits in attentio n and executive function. (PubMed id 21531385)1 Liu C.M....Hwu H.G. (2011)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    10. Differential gene expression identified in Uigur wome n cervical squamous cell carcinoma by suppression subtractive hybridization. (PubMed id 20099975)1 Pan Z....Shao R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23234 HGNC: 19123 AceView: DNAJC9andMRPS16 Ensembl:ENSG00000213551 euGenes: HUgn23234
    ECgene: DNAJC9 H-InvDB: DNAJC9

    (According to HUGE)
    About This Section
    HUGE: KIAA0974

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DNAJC9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DNAJC9 gene:
    Search GeneIP for patents involving DNAJC9

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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    von Willebrand factor
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