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Aliases for DNAJC8 Gene

Aliases for DNAJC8 Gene

  • DnaJ (Hsp40) Homolog, Subfamily C, Member 8 2 3
  • Splicing Protein Spf31 3 4
  • SPF31 3 4
  • HSPC331 3

External Ids for DNAJC8 Gene

Previous GeneCards Identifiers for DNAJC8 Gene

  • GC01P026900
  • GC01M027537
  • GC01M027760
  • GC01M028131
  • GC01M028399
  • GC01M028526
  • GC01M026783

Summaries for DNAJC8 Gene

GeneCards Summary for DNAJC8 Gene

DNAJC8 (DnaJ (Hsp40) Homolog, Subfamily C, Member 8) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC8 Gene

Genomics for DNAJC8 Gene

Regulatory Elements for DNAJC8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DNAJC8 Gene

28,199,456 bp from pter
28,233,031 bp from pter
33,576 bases
Minus strand

Genomic View for DNAJC8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC8 Gene

Proteins for DNAJC8 Gene

  • Protein details for DNAJC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily C member 8
    Protein Accession:
    Secondary Accessions:
    • B4DUU4
    • D3DPM0
    • Q6IBA4
    • Q8N4Z5
    • Q9P051
    • Q9P067

    Protein attributes for DNAJC8 Gene

    253 amino acids
    Molecular mass:
    29842 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC35352.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAG33181.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DNAJC8 Gene

Proteomics data for DNAJC8 Gene at MOPED

Post-translational modifications for DNAJC8 Gene

  • Ubiquitination at Lys 108 and Lys 210
  • Modification sites at PhosphoSitePlus

Other Protein References for DNAJC8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJC8 Gene

Domains & Families for DNAJC8 Gene

Gene Families for DNAJC8 Gene

Protein Domains for DNAJC8 Gene


Suggested Antigen Peptide Sequences for DNAJC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 J domain.
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJC8: view

Function for DNAJC8 Gene

genes like me logo Genes that share phenotypes with DNAJC8: view

Animal Model Products

miRNA for DNAJC8 Gene

miRTarBase miRNAs that target DNAJC8

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJC8 Gene

Localization for DNAJC8 Gene

Subcellular locations from

Jensen Localization Image for DNAJC8 Gene COMPARTMENTS Subcellular localization image for DNAJC8 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for DNAJC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with DNAJC8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DNAJC8 Gene

Pathways & Interactions for DNAJC8 Gene

genes like me logo Genes that share pathways with DNAJC8: view

Pathways by source for DNAJC8 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DNAJC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with DNAJC8: view

No data available for SIGNOR curated interactions for DNAJC8 Gene

Drugs & Compounds for DNAJC8 Gene

No Compound Related Data Available

Transcripts for DNAJC8 Gene

Unigene Clusters for DNAJC8 Gene

DnaJ (Hsp40) homolog, subfamily C, member 8:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJC8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC8 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c
SP1: - - - - - -
SP2: - - - - - -
SP3: - -
SP4: - -
SP5: - - -
SP6: - - - - - - - - - - - -
SP7: -

Relevant External Links for DNAJC8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJC8 Gene

mRNA expression in normal human tissues for DNAJC8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJC8 Gene

This gene is overexpressed in Lavage (11.5), Lymph node (9.7), and Heart (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJC8 Gene

SOURCE GeneReport for Unigene cluster for DNAJC8 Gene Hs.433540

genes like me logo Genes that share expression patterns with DNAJC8: view

Protein tissue co-expression partners for DNAJC8 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DNAJC8 Gene

Orthologs for DNAJC8 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAJC8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DNAJC8 35
  • 94.86 (n)
  • 98.81 (a)
  • 96 (a)
(Canis familiaris)
Mammalia DNAJC8 35
  • 94.47 (n)
  • 98.42 (a)
  • 98 (a)
(Mus musculus)
Mammalia Dnajc8 35
  • 90.78 (n)
  • 99.21 (a)
Dnajc8 16
Dnajc8 36
  • 99 (a)
(Pan troglodytes)
Mammalia DNAJC8 35
  • 99.87 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Dnajc8 35
  • 90.51 (n)
  • 99.21 (a)
(Monodelphis domestica)
Mammalia DNAJC8 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia DNAJC8 36
  • 98 (a)
(Gallus gallus)
Aves DNAJC8 35
  • 83.55 (n)
  • 94.85 (a)
  • 92 (a)
(Anolis carolinensis)
Reptilia DNAJC8 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc8 35
  • 78.49 (n)
  • 90.17 (a)
Str.10589 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24686 35
(Danio rerio)
Actinopterygii -- 35
dnajc8 35
  • 74.33 (n)
  • 85.11 (a)
dnajc8 36
  • 82 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10375 37
  • 51 (a)
CG10375 35
  • 54.65 (n)
  • 54.51 (a)
CG10375 36
  • 51 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005298 35
  • 56.51 (n)
  • 56.65 (a)
(Caenorhabditis elegans)
Secernentea dnj-30 35
  • 55.12 (n)
  • 48.05 (a)
dnj-30 36
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
Species with no ortholog for DNAJC8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC8 Gene

Gene Tree for DNAJC8 (if available)
Gene Tree for DNAJC8 (if available)

Paralogs for DNAJC8 Gene

genes like me logo Genes that share paralogs with DNAJC8: view

No data available for Paralogs for DNAJC8 Gene

Variants for DNAJC8 Gene

Sequence variations from dbSNP and Humsavar for DNAJC8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8678 -- 28,201,143(-) TATTT(C/G)CTTTT utr-variant-3-prime
rs9447 -- 28,200,900(-) ATCCA(A/G)TTAAA utr-variant-3-prime
rs372922 -- 28,231,886(+) cctca(G/T)cctcc intron-variant
rs385314 -- 28,207,838(+) atcac(C/T)tgagg intron-variant
rs399449 -- 28,227,016(-) CTTCA(A/G)AAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC8 Gene

Variant ID Type Subtype PubMed ID
nsv871151 CNV Gain 21882294
esv2674175 CNV Deletion 23128226

Variation tolerance for DNAJC8 Gene

Residual Variation Intolerance Score: 43.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.66; 78.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC8 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC8 Gene

Disorders for DNAJC8 Gene

Relevant External Links for DNAJC8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DNAJC8: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC8 Gene

Publications for DNAJC8 Gene

  1. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K. … Hata M. (Cell Stress Chaperones 2000) 2 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  3. Quantitative Lys-I/-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. (PMID: 25147182) Thompson J.W. … Luchansky S.J. (J. Biol. Chem. 2014) 67
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  5. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 67

Products for DNAJC8 Gene

Sources for DNAJC8 Gene

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