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Aliases for DNAJC8 Gene

Aliases for DNAJC8 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C8 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 8 2 3
  • Splicing Protein Spf31 3 4
  • SPF31 3 4
  • DnaJ Homolog Subfamily C Member 8 3
  • HSPC331 3

External Ids for DNAJC8 Gene

Previous GeneCards Identifiers for DNAJC8 Gene

  • GC01P026900
  • GC01M027537
  • GC01M027760
  • GC01M028131
  • GC01M028399
  • GC01M028526
  • GC01M026783

Summaries for DNAJC8 Gene

GeneCards Summary for DNAJC8 Gene

DNAJC8 (DnaJ Heat Shock Protein Family (Hsp40) Member C8) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC8 Gene

Genomics for DNAJC8 Gene

Regulatory Elements for DNAJC8 Gene

Enhancers for DNAJC8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F028258 1.1 ENCODE 20.9 -26.9 -26938 3.7 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A YY1 ZNF416 ZNF207 ZNF143 SNHG12 TRNAU1AP LOC105376896 PHACTR4 DNAJC8 TMEM200B AHDC1 GMEB1 SNORA73B ACTG1P20
GH01F028122 1.5 FANTOM5 Ensembl ENCODE 11.8 +109.8 109801 2.5 HDAC1 ATF1 PKNOX1 ZNF121 ZNF766 CREM SMARCA5 MIER1 CEBPB ZEB2 PTAFR EYA3 FGR DNAJC8 ATPIF1 SESN2 THEMIS2 SCARNA1 RNU6-1245P PPP1R8
GH01F028125 1.4 FANTOM5 Ensembl ENCODE 12.4 +105.4 105431 4.8 PKNOX1 BMI1 SCRT2 ETV6 FOS USF2 CEBPB ZEB2 TBX21 RAD51 PTAFR EYA3 DNAJC8 FGR ATPIF1 PPP1R8 RNU6-1245P SCARNA1 THEMIS2 SESN2
GH01F027487 1.4 Ensembl ENCODE 11.5 +742.3 742312 5.8 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF416 ZNF143 ACTG1P20 NPM1P39 PHACTR4 AHDC1 ENSG00000231344 CD164L2 LOC105376890 WASF2 ENSG00000243659 DNAJC8
GH01F028152 1.5 FANTOM5 Ensembl ENCODE 10.6 +78.8 78756 2.6 PKNOX1 MLX ARID4B ZNF48 ZNF121 GATA2 KLF7 FOS SP5 PPARG PTAFR XKR8 THEMIS2 EYA3 DNAJC8 ATPIF1 LOC105376896 SESN2 MED18 STX12
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DNAJC8 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJC8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000533467 331 1801 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 FOS KLF13 SP3

Genomic Location for DNAJC8 Gene

Chromosome:
1
Start:
28,199,456 bp from pter
End:
28,233,031 bp from pter
Size:
33,576 bases
Orientation:
Minus strand

Genomic View for DNAJC8 Gene

Genes around DNAJC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC8 Gene

Proteins for DNAJC8 Gene

  • Protein details for DNAJC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75937-DNJC8_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 8
    Protein Accession:
    O75937
    Secondary Accessions:
    • B4DUU4
    • D3DPM0
    • Q6IBA4
    • Q8N4Z5
    • Q9P051
    • Q9P067

    Protein attributes for DNAJC8 Gene

    Size:
    253 amino acids
    Molecular mass:
    29842 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC35352.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAG33181.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DNAJC8 Gene

Post-translational modifications for DNAJC8 Gene

  • Ubiquitination at Lys 108 and Lys 210
  • Modification sites at PhosphoSitePlus

Other Protein References for DNAJC8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJC8 Gene

Domains & Families for DNAJC8 Gene

Gene Families for DNAJC8 Gene

Protein Domains for DNAJC8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DNAJC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75937

UniProtKB/Swiss-Prot:

DNJC8_HUMAN :
  • Contains 1 J domain.
Domain:
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJC8: view

Function for DNAJC8 Gene

genes like me logo Genes that share phenotypes with DNAJC8: view

Animal Models for DNAJC8 Gene

MGI Knock Outs for DNAJC8:

Animal Model Products

miRNA for DNAJC8 Gene

miRTarBase miRNAs that target DNAJC8

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DNAJC8 Gene

Localization for DNAJC8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJC8 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4

Gene Ontology (GO) - Cellular Components for DNAJC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IDA --
GO:0045171 intercellular bridge IDA --
genes like me logo Genes that share ontologies with DNAJC8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DNAJC8 Gene

Pathways & Interactions for DNAJC8 Gene

genes like me logo Genes that share pathways with DNAJC8: view

Pathways by source for DNAJC8 Gene

Gene Ontology (GO) - Biological Process for DNAJC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
genes like me logo Genes that share ontologies with DNAJC8: view

No data available for SIGNOR curated interactions for DNAJC8 Gene

Transcripts for DNAJC8 Gene

Unigene Clusters for DNAJC8 Gene

DnaJ (Hsp40) homolog, subfamily C, member 8:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC8 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c
SP1: - - - - - -
SP2: - - - - - -
SP3: - -
SP4: - -
SP5: - - -
SP6: - - - - - - - - - - - -
SP7: -

Relevant External Links for DNAJC8 Gene

GeneLoc Exon Structure for
DNAJC8
ECgene alternative splicing isoforms for
DNAJC8

Expression for DNAJC8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DNAJC8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJC8 Gene

This gene is overexpressed in Lavage (11.5), Lymph node (9.7), and Heart (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNAJC8 Gene



Protein tissue co-expression partners for DNAJC8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJC8 Gene:

DNAJC8

SOURCE GeneReport for Unigene cluster for DNAJC8 Gene:

Hs.433540
genes like me logo Genes that share expression patterns with DNAJC8: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DNAJC8 Gene

Orthologs for DNAJC8 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAJC8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC8 34 35
  • 99.87 (n)
oppossum
(Monodelphis domestica)
Mammalia DNAJC8 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC8 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAJC8 34 35
  • 94.86 (n)
dog
(Canis familiaris)
Mammalia DNAJC8 34 35
  • 94.47 (n)
mouse
(Mus musculus)
Mammalia Dnajc8 34 16 35
  • 90.78 (n)
rat
(Rattus norvegicus)
Mammalia Dnajc8 34
  • 90.51 (n)
chicken
(Gallus gallus)
Aves DNAJC8 34 35
  • 83.55 (n)
lizard
(Anolis carolinensis)
Reptilia DNAJC8 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc8 34
  • 78.49 (n)
Str.10589 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24686 34
zebrafish
(Danio rerio)
Actinopterygii dnajc8 34 35
  • 74.33 (n)
-- 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005298 34
  • 56.51 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10375 36 34 35
  • 54.65 (n)
worm
(Caenorhabditis elegans)
Secernentea dnj-30 34 35
  • 55.12 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 51 (a)
OneToOne
Species where no ortholog for DNAJC8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC8 Gene

ENSEMBL:
Gene Tree for DNAJC8 (if available)
TreeFam:
Gene Tree for DNAJC8 (if available)

Paralogs for DNAJC8 Gene

genes like me logo Genes that share paralogs with DNAJC8: view

No data available for Paralogs for DNAJC8 Gene

Variants for DNAJC8 Gene

Sequence variations from dbSNP and Humsavar for DNAJC8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1049274 -- 28,201,322(-) CCAAT(A/C)CGAAG reference, missense
rs1049504 -- 28,200,500(-) TTGGC(C/T)GAACC utr-variant-3-prime
rs111300134 -- 28,217,602(+) ACAGA(C/T)GAGGG intron-variant
rs111370352 -- 28,216,066(+) CTCCC(C/T)GGCCG intron-variant
rs111371237 -- 28,221,352(+) GAAAA(-/AGAGAAAGAAAC)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC8 Gene

Variant ID Type Subtype PubMed ID
nsv945854 CNV duplication 23825009
nsv545916 CNV gain 21841781
esv3585575 CNV loss 21293372
esv3559959 CNV deletion 23714750
esv2674175 CNV deletion 23128226

Variation tolerance for DNAJC8 Gene

Residual Variation Intolerance Score: 44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.66; 78.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJC8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC8 Gene

Disorders for DNAJC8 Gene

Relevant External Links for DNAJC8

Genetic Association Database (GAD)
DNAJC8
Human Genome Epidemiology (HuGE) Navigator
DNAJC8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJC8

No disorders were found for DNAJC8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC8 Gene

Publications for DNAJC8 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K. … Hata M. (Cell Stress Chaperones 2000) 2 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for DNAJC8 Gene

Sources for DNAJC8 Gene

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