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DNAJC7 Gene

protein-coding   GIFtS: 55
GCID: GC17M040128

DnaJ (Hsp40) Homolog, Subfamily C, Member 7


(Previous symbol: TTC2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DnaJ (Hsp40) Homolog, Subfamily C, Member 71 2     DJ112
TTC21 2 3 5     DJC72
TPR22 3 5     DnaJ Homolog Subfamily C Member 72
Tetratricopeptide Repeat Protein 22 3     Tetratricopeptide Repeat Domain 22
TPR Repeat Protein 22 3     DANJC75

External Ids:    HGNC: 123921   Entrez Gene: 72662   Ensembl: ENSG000001682597   OMIM: 6019645   UniProtKB: Q996153   

Export aliases for DNAJC7 gene to outside databases

Previous GC identifers: GC17M039682 GC17M042284 GC17M040037 GC17M040501 GC17M037382 GC17M035893


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNAJC7 Gene:
This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two
N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chaperone
proteins heat shock proteins 70 and 90 in an ATP-dependent manner and may function as a co-chaperone. Pseudogenes
of this gene are found on chromosomes 1 and 6. Alternate splicing results in multiple transcript
variants.(provided by RefSeq, Oct 2009)

GeneCards Summary for DNAJC7 Gene:
DNAJC7 (DnaJ (Hsp40) homolog, subfamily C, member 7) is a protein-coding gene. GO annotations related to this gene include heat shock protein binding. An important paralog of this gene is DNAJC3.

UniProtKB/Swiss-Prot: DNJC7_HUMAN, Q99615
Function: Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid
receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling
chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is
required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate
complexes. Recruits NR1I3 to the cytoplasm (By similarity)

Gene Wiki entry for DNAJC7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAJC7 gene promoter:
         p53   NRSF form 1   CUTL1   NRSF form 2   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJC7 promoter sequence
   Search Chromatin IP Primers for DNAJC7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAJC7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q11.2

DNAJC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJC7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M040128:  view genomic region     (about GC identifiers)

Start:
40,128,439 bp from pter      End:
40,173,394 bp from pter
Size:
44,956 bases      Orientation:
minus strand

1 alternative location:
Chr17-,NW_003571052 263,063-304,339     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DNJC7_HUMAN, Q99615 (See protein sequence)
Recommended Name: DnaJ homolog subfamily C member 7  
Size: 494 amino acids; 56441 Da
Subunit: Associates with complexes containing chaperones HSP70 and HSP90. Interacts with the GAP domain of NF1.
Interacts with HSP90AA1. Interacts with HSPA1A/B; the interaction is enhanced by ATP. Interacts with HSP90AB1.
Interacts with PGR. Interacts with RAD9A; the interaction is interrupted by UV and heat shock treatments.
Interacts with HUS1 and RAD1. Interacts with NR1I3. The DNAJC7-NR1I3 complex may also include HSP90 (By
similarity). Interacts with HSPA8
Sequence caution: Sequence=AAB36872.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH33772.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q7Z784
Alternative splicing: 2 isoforms:  Q99615-1   Q99615-2   

Explore the universe of human proteins at neXtProt for DNAJC7: NX_Q99615

Explore proteomics data for DNAJC7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys60, Lys128, Lys182, Lys273, Lys329, Lys368, Lys384, Lys390
  • Modification sites at PhosphoSitePlus

  • See DNAJC7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138238.1  NP_003306.3  

    ENSEMBL proteins: 
     ENSP00000406463   ENSP00000467702   ENSP00000394327   ENSP00000466114   ENSP00000313311  
     ENSP00000464993   ENSP00000467477   ENSP00000468805   ENSP00000464756   ENSP00000468102  
     ENSP00000465340   ENSP00000466748   ENSP00000466877   ENSP00000465228   ENSP00000465399  
     ENSP00000465140  

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    Novus Biologicals DNAJC7 Protein
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    Cloud-Clone Corp. Proteins for DNAJC7

     
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    DNAJC7 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DNAJ: Heat shock proteins / DNAJ (HSP40)
    TTC: Tetratricopeptide (TTC) repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR011990 TPR-like_helical
     IPR001440 TPR_1
     IPR001623 DnaJ_domain
     IPR013105 TPR_2
     IPR013026 TPR-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q99615

    ProtoNet protein and cluster: Q99615

    UniProtKB/Swiss-Prot: DNJC7_HUMAN, Q99615
    Similarity: Contains 1 J domain
    Similarity: Contains 9 TPR repeats


    Find genes that share domains with DNAJC7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DNJC7_HUMAN, Q99615
    Function: Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid
    receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling
    chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is
    required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate
    complexes. Recruits NR1I3 to the cytoplasm (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0031072heat shock protein binding IPI12853476
         
    Find genes that share ontologies with DNAJC7           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DNAJC7:
     Increased cell death HMECs cel  Increased cell death in breast 

         1 MGI phenotypic allele for Dnajc7 (no phenotypes)

    Find genes that share phenotypes with DNAJC7           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNAJC7
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DNAJC7
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    miRNA
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    miRTarBase miRNAs that target DNAJC7:
    hsa-mir-181a-5p (MIRT025156), hsa-mir-877-3p (MIRT037064)

    Block miRNA regulation of human, mouse, rat DNAJC7 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate DNAJC7:
    hsa-miR-142-5p hsa-miR-513b hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidDNAJC7 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DNAJC7

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    GenScript: all cDNA clones in your preferred vector (see all 2): DNAJC7 (NM_003315)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJC7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC7

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DNAJC7 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DNJC7_HUMAN, Q99615: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Note=Colocalizes with NR1I3 to microtubules (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol3
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005856cytoskeleton IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with DNAJC7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJC7: 
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DNAJC7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNAJC7 (Q996151, 2, 3 ENSP000004064634) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157962, 3, ENSP000002621604MINT-61584 I2D: score=3 STRING: ENSP00000262160
    TAB1Q157502, 3, ENSP000002161604MINT-49180 I2D: score=2 STRING: ENSP00000216160
    MAP3K3Q997592, 3MINT-48516 I2D: score=2 
    SMAD9O151982, 3, ENSP000003691544MINT-62135 I2D: score=3 STRING: ENSP00000369154
    RAD9AQ996383, ENSP000003113604I2D: score=4 STRING: ENSP00000311360
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS8836031
    GO:0070389chaperone cofactor-dependent protein refolding IDA12853476

    Find genes that share ontologies with DNAJC7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNAJC7 (DNJC7)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DNAJC7 gene (2 alternative transcripts): 
    NM_001144766.2  NM_003315.3  

    Unigene Cluster for DNAJC7:

    DnaJ (Hsp40) homolog, subfamily C, member 7
    Hs.500156  [show with all ESTs]
    Unigene Representative Sequence: AK126179
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000457167(uc002hyo.3 uc002hyp.3 uc010wgc.2) ENST00000587727
    ENST00000426588(uc010wgb.2 uc010cxw.3) ENST00000588814 ENST00000316603
    ENST00000585693 ENST00000586335 ENST00000590197 ENST00000590847 ENST00000589810
    ENST00000588641 ENST00000590348 ENST00000591153 ENST00000589576 ENST00000590774
    ENST00000589586 ENST00000585866 ENST00000589773
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DNAJC7 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate DNAJC7:
    hsa-miR-142-5p hsa-miR-513b hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidDNAJC7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DNAJC7
    Predesigned siRNA for gene silencing in human, mouse, rat DNAJC7
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DNAJC7 (NM_003315)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJC7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC7
    Primer
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    OriGene qPCR primer pairs and template standards for DNAJC7
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJC7
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      QuantiTect SYBR Green Assays in human, mouse, rat DNAJC7
      QuantiFast Probe-based Assays in human, mouse, rat DNAJC7

    Additional mRNA sequence: 

    AB209834.1 AK126179.1 AK291047.1 AK296602.1 AK298860.1 AK308016.1 AK316081.1 AL832812.1 
    BC003601.1 BC011837.2 BC033772.1 BX647209.1 NR_029431.1 U46571.1 

    Selected DOTS entries (see all 30):

    DT.416333  DT.100699901  DT.100820692  DT.100683725  DT.99992907  DT.100820696  DT.91678481  DT.101977393 
    DT.101955210  DT.75165174  DT.407400  DT.100820697  DT.102836836  DT.95165897  DT.100820693  DT.101961705 
    DT.40106795  DT.97854708  DT.120967377  DT.120967402  DT.120967436  DT.120967546  DT.100809708  DT.120967419 

    Selected AceView cDNA sequences (see all 357):

    AA729887 BX418120 AL832812 BU687415 BM799289 BM806093 BU688592 AL534086 
    AA639418 AA846510 AL565274 AI245269 BE560927 BU681849 BM468605 BP351095 
    BQ953471 AL556987 AA664170 CR609021 AW262249 BM665364 AA232785 BM854582 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC7    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14
    SP1:        -     -           -                                                                           
    SP2:              -           -                                                                           
    SP3:                                                                                      -               
    SP4:                                                                    -                                 
    SP5:                    -                                                                                 


    ECgene alternative splicing isoforms for DNAJC7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNAJC7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATATGGGTG
    DNAJC7 Expression
    About this image


    DNAJC7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
     
     Ovary (Reproductive System)
     
     Testis (Reproductive System)
     
     Esophagus (Gastrointestinal Tract)
    DNAJC7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAJC7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.500156
        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJC7: 
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DNAJC7
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJC7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAJC7
    QuantiTect SYBR Green Assays in human, mouse, rat DNAJC7
    QuantiFast Probe-based Assays in human, mouse, rat DNAJC7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNAJC7 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnajc71 , 5 DnaJ (Hsp40) homolog, subfamily C, member 71, 5 91.63(n)1
    97.17(a)1
      11 (63.47 cM)5
    563541  NM_019795.41  NP_062769.21 
     1005828185 
    chicken
    (Gallus gallus)
    Aves DNAJC71 DnaJ (Hsp40) homolog, subfamily C, member 7 83.54(n)
    93.7(a)
      428312  NM_001031502.2  NP_001026673.2 
    lizard
    (Anolis carolinensis)
    Reptilia DNAJC76
    DnaJ (Hsp40) homolog, subfamily C, member 7
    86(a)
    1 ↔ 1
    6(66365565-66401337)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.334122 Xenopus laevis transcribed sequence with moderate similarity more 79(n)    BX847549.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa20d062 Transcribed sequence with moderate similarity to protein more 77.27(n)    BI887624.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tpr21 , 3 Tetratricopeptide repeat protein 21 47(a)3
    53.21(n)1
    47.01(a)1
      36A23
    349841  NM_078860.31  NP_523584.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons P58IPK1 P58IPK 44.15(n)
    30.73(a)
      831917  NM_120394.3  NP_195936.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g01953001 Os02g0195300 49.31(n)
    38.19(a)
      4328607  NM_001052719.2  NP_001046184.2 


    ENSEMBL Gene Tree for DNAJC7 (if available)
    TreeFam Gene Tree for DNAJC7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNAJC7 gene
    DNAJC32  
    4 SIMAP similar genes for DNAJC7 using alignment to 14 protein entries:     DNJC7_HUMAN (see all proteins):
    SGTB    PPP5C    STIP1    DNAJB3

    Find genes that share paralogs with DNAJC7           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for DNAJC7
    PGOHUM00000244053 PGOHUM00000243793


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNAJC7 (see all 644)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1142717591,2
    C,F--40130584(+) CCTACT/CTAAAA 3 -- int11Minor allele frequency- C:0.18WA 118
    rs2004203381,2
    --40130631(+) CCAGC-/ACTTTG 3 -- int10--------
    rs1881941091,2
    C--40130775(+) TGCCTA/GTAGTC 3 -- int10--------
    rs2005760581,2
    C--40130792(+) ACTTGA/GGAGGC 3 -- int10--------
    rs1929555671,2
    --40130823(+) AACCCA/GGGAGG 3 -- int10--------
    rs1843099291,2
    C--40130923(+) CACTAC/GTTTTT 3 -- int10--------
    rs1894737521,2
    --40130980(+) TTGTGA/GTGAAC 3 -- int10--------
    rs1817382041,2
    --40131267(+) CAGGAC/GAATTT 3 -- int10--------
    rs2013507201,2
    --40131370(+) ACAAC-/AAAAAA 3 -- int10--------
    rs1837097141,2
    --40131373(+) AACAAA/CAAAAA 3 -- int10--------

    HapMap Linkage Disequilibrium report for DNAJC7 (40128439 - 40173394 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DNAJC7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509658CNV Insertion20534489
    nsv908239CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAJC7
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAJC7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601964    OMIM disorders: --


    Find genes that share disorders with DNAJC7           About GenesLikeMe


    Export disorders for DNAJC7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNAJC7 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with DNAJC7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of two novel tetratricopeptide repeat-containing genes. (PubMed id 8836031)1, 2, 3, 9 Murthy A.E.... Gusella J.F. (DNA Cell Biol. 1996)
    2. The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9. (PubMed id 11573955)1, 2, 9 Xiang S.L....Yamamoto K.C. (Biochem. Biophys. Res. Commun. 2001)
    3. Role of the cochaperone Tpr2 in Hsp90 chaperoning. (PubMed id 18620420)1, 2 Moffatt N.S.... Toft D. (Biochemistry 2008)
    4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. (PubMed id 12853476)1, 2 Brychzy A....Obermann W.M. (EMBO J. 2003)
    7. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PubMed id 11147971)1, 3 Ohtsuka K. and Hata M. (Cell Stress Chaperones 2000)
    8. Specific interaction of the 70-kDa heat shock cognate protein with the tetratricopeptide repeats. (PubMed id 10567422)1, 2 Liu F.H.... Wang C. (J. Biol. Chem. 1999)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. Co-chaperon DnaJC7/TPR2 enhances p53 stability and activity through blocking the complex formation between p53 and MDM2. (PubMed id 23261415)1 Kubo N....Ozaki T. (Biochem. Biophys. Res. Commun. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7266 HGNC: 12392 AceView: DNAJC7 Ensembl:ENSG00000168259 euGenes: HUgn7266
    ECgene: DNAJC7 H-InvDB: DNAJC7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DNAJC7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNAJC7 gene:
    Search GeneIP for patents involving DNAJC7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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