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Aliases for DNAJC7 Gene

Aliases for DNAJC7 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C7 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 7 2 3
  • Tetratricopeptide Repeat Protein 2 3 4
  • TPR Repeat Protein 2 3 4
  • TTC2 3 4
  • TPR2 3 4
  • DnaJ Homolog Subfamily C Member 7 3
  • Tetratricopeptide Repeat Domain 2 3
  • DJ11 3
  • DJC7 3

External Ids for DNAJC7 Gene

Previous HGNC Symbols for DNAJC7 Gene

  • TTC2

Previous GeneCards Identifiers for DNAJC7 Gene

  • GC17M039682
  • GC17M042284
  • GC17M040037
  • GC17M040501
  • GC17M037382
  • GC17M040128
  • GC17M035893

Summaries for DNAJC7 Gene

Entrez Gene Summary for DNAJC7 Gene

  • This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chaperone proteins heat shock proteins 70 and 90 in an ATP-dependent manner and may function as a co-chaperone. Pseudogenes of this gene are found on chromosomes 1 and 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

GeneCards Summary for DNAJC7 Gene

DNAJC7 (DnaJ Heat Shock Protein Family (Hsp40) Member C7) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Cellular response to heat stress. GO annotations related to this gene include heat shock protein binding. An important paralog of this gene is DNAJC3.

UniProtKB/Swiss-Prot for DNAJC7 Gene

  • Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity).

Gene Wiki entry for DNAJC7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC7 Gene

Genomics for DNAJC7 Gene

Regulatory Elements for DNAJC7 Gene

Enhancers for DNAJC7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DNAJC7 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJC7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DNAJC7 on UCSC Golden Path with GeneCards custom track

Genomic Location for DNAJC7 Gene

Chromosome:
17
Start:
41,974,005 bp from pter
End:
42,021,376 bp from pter
Size:
47,372 bases
Orientation:
Minus strand

Genomic View for DNAJC7 Gene

Genes around DNAJC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC7 Gene

Proteins for DNAJC7 Gene

  • Protein details for DNAJC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99615-DNJC7_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 7
    Protein Accession:
    Q99615
    Secondary Accessions:
    • Q7Z784

    Protein attributes for DNAJC7 Gene

    Size:
    494 amino acids
    Molecular mass:
    56441 Da
    Quaternary structure:
    • Associates with complexes containing chaperones HSP70 and HSP90. Interacts with the GAP domain of NF1. Interacts with HSP90AA1. Interacts with HSPA1A/B; the interaction is enhanced by ATP. Interacts with HSP90AB1. Interacts with PGR. Interacts with RAD9A; the interaction is interrupted by UV and heat shock treatments. Interacts with HUS1 and RAD1. Interacts with NR1I3. The DNAJC7-NR1I3 complex may also include HSP90 (By similarity). Interacts with HSPA8.
    SequenceCaution:
    • Sequence=AAB36872.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH33772.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAJC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJC7 Gene

Post-translational modifications for DNAJC7 Gene

  • Ubiquitination at Lys 60, Lys 128, Lys 182, Lys 273, Lys 329, Lys 368, Lys 384, and Lys 390
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DNAJC7 Gene

Domains & Families for DNAJC7 Gene

Protein Domains for DNAJC7 Gene

Suggested Antigen Peptide Sequences for DNAJC7 Gene

Graphical View of Domain Structure for InterPro Entry

Q99615

UniProtKB/Swiss-Prot:

DNJC7_HUMAN :
  • Contains 1 J domain.
  • Contains 9 TPR repeats.
Domain:
  • Contains 1 J domain.
Similarity:
  • Contains 9 TPR repeats.
genes like me logo Genes that share domains with DNAJC7: view

Function for DNAJC7 Gene

Molecular function for DNAJC7 Gene

UniProtKB/Swiss-Prot Function:
Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity).

Gene Ontology (GO) - Molecular Function for DNAJC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity TAS --
GO:0005515 protein binding IPI 22190034
GO:0031072 heat shock protein binding IPI 12853476
genes like me logo Genes that share ontologies with DNAJC7: view
genes like me logo Genes that share phenotypes with DNAJC7: view

Animal Models for DNAJC7 Gene

MGI Knock Outs for DNAJC7:

Animal Model Products

CRISPR Products

miRNA for DNAJC7 Gene

miRTarBase miRNAs that target DNAJC7

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DNAJC7 Gene

Localization for DNAJC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC7 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Note=Colocalizes with NR1I3 to microtubules. {ECO:0000250 UniProtKB:Q9QYI3}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJC7 Gene COMPARTMENTS Subcellular localization image for DNAJC7 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
cytoskeleton 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DNAJC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 12853476
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DNAJC7: view

Pathways & Interactions for DNAJC7 Gene

genes like me logo Genes that share pathways with DNAJC7: view

Pathways by source for DNAJC7 Gene

Gene Ontology (GO) - Biological Process for DNAJC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 8836031
GO:0032781 positive regulation of ATPase activity IEA --
GO:0070389 chaperone cofactor-dependent protein refolding IDA 12853476
GO:1900034 regulation of cellular response to heat TAS --
genes like me logo Genes that share ontologies with DNAJC7: view

No data available for SIGNOR curated interactions for DNAJC7 Gene

Drugs & Compounds for DNAJC7 Gene

No Compound Related Data Available

Transcripts for DNAJC7 Gene

Unigene Clusters for DNAJC7 Gene

DnaJ (Hsp40) homolog, subfamily C, member 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14
SP1: - - -
SP2: - -
SP3: -
SP4: -
SP5: -

Relevant External Links for DNAJC7 Gene

GeneLoc Exon Structure for
DNAJC7
ECgene alternative splicing isoforms for
DNAJC7

Expression for DNAJC7 Gene

mRNA expression in normal human tissues for DNAJC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJC7 Gene

This gene is overexpressed in Breast (41.6) and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNAJC7 Gene



Protein tissue co-expression partners for DNAJC7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJC7 Gene:

DNAJC7

SOURCE GeneReport for Unigene cluster for DNAJC7 Gene:

Hs.500156
genes like me logo Genes that share expression patterns with DNAJC7: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DNAJC7 Gene

Orthologs for DNAJC7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJC7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNAJC7 34
  • 94.2 (n)
  • 98.18 (a)
DNAJC7 35
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJC7 34
  • 94.8 (n)
  • 98.38 (a)
DNAJC7 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajc7 34
  • 91.63 (n)
  • 97.17 (a)
Dnajc7 16
Dnajc7 35
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DNAJC7 34
  • 99.85 (n)
  • 99.77 (a)
DNAJC7 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajc7 34
  • 91.43 (n)
  • 97.17 (a)
oppossum
(Monodelphis domestica)
Mammalia DNAJC7 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC7 35
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJC7 34
  • 83.54 (n)
  • 93.7 (a)
DNAJC7 35
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJC7 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc7 34
  • 76.81 (n)
  • 84.79 (a)
Str.6019 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.33412 34
zebrafish
(Danio rerio)
Actinopterygii dnajc7 34
  • 73.46 (n)
  • 83.23 (a)
wufa20d06 34
dnajc7 35
  • 77 (a)
OneToMany
dnajc7 35
  • 77 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9695 34
fruit fly
(Drosophila melanogaster)
Insecta Tpr2 36
  • 47 (a)
Tpr2 34
  • 53.21 (n)
  • 47.01 (a)
Tpr2 35
  • 44 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008985 34
  • 52.21 (n)
  • 49.36 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons P58IPK 34
  • 44.15 (n)
  • 30.73 (a)
rice
(Oryza sativa)
Liliopsida Os02g0195300 34
  • 49.31 (n)
  • 38.19 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00170 34
  • 48.25 (n)
  • 39.95 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC543.02c 34
  • 49.27 (n)
  • 43.69 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
OneToOne
Species where no ortholog for DNAJC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAJC7 Gene

ENSEMBL:
Gene Tree for DNAJC7 (if available)
TreeFam:
Gene Tree for DNAJC7 (if available)

Paralogs for DNAJC7 Gene

Pseudogenes.org Pseudogenes for DNAJC7 Gene

genes like me logo Genes that share paralogs with DNAJC7: view

Variants for DNAJC7 Gene

Sequence variations from dbSNP and Humsavar for DNAJC7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1127182 -- 41,990,284(-) TATCC(A/G)GAAGC nc-transcript-variant, reference, synonymous-codon
rs4239268 -- 42,002,759(+) AATTA(A/G)TCTGT intron-variant
rs4378665 -- 41,991,918(+) tcaag(C/T)gatcc intron-variant
rs4534906 -- 42,005,139(+) TCTCT(C/G)AATTC intron-variant
rs4796624 -- 41,985,787(+) TACTT(C/T)TTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC7 Gene

Variant ID Type Subtype PubMed ID
esv3554435 CNV deletion 23714750
esv3640597 CNV loss 21293372
nsv1146669 OTHER inversion 26484159
nsv476975 CNV novel sequence insertion 20440878
nsv509658 CNV insertion 20534489
nsv953897 CNV deletion 24416366

Variation tolerance for DNAJC7 Gene

Residual Variation Intolerance Score: 26.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC7 Gene

Disorders for DNAJC7 Gene

Relevant External Links for DNAJC7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJC7

No disorders were found for DNAJC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC7 Gene

Publications for DNAJC7 Gene

  1. Identification and characterization of two novel tetratricopeptide repeat-containing genes. (PMID: 8836031) Murthy A.E. … Gusella J.F. (DNA Cell Biol. 1996) 2 3 4 22 65
  2. The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9. (PMID: 11573955) Xiang S.L. … Yamamoto K.C. (Biochem. Biophys. Res. Commun. 2001) 3 4 22 65
  3. Role of the cochaperone Tpr2 in Hsp90 chaperoning. (PMID: 18620420) Moffatt N.S. … Toft D. (Biochemistry 2008) 3 4 65
  4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for DNAJC7 Gene

Sources for DNAJC7 Gene

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