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DNAJC7 Gene

protein-coding   GIFtS: 57

GC17M037382
DnaJ (Hsp40) homolog, subfamily C, member 7
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: TTC2)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DANJC7 2
DJ11 2
TPR2 1, 2, 3
TTC2 2, 3
Descriptions
DnaJ (Hsp40) homolog, subfamily C, member 7 2
TPR repeat protein 2 3
Tetratricopeptide repeat protein 2 3
tetratricopeptide repeat domain 2 2
External Ids
HGNC: 123921
Entrez Gene: 72662
UniProtKB: Q996153
Ensembl: ENSG000001682597
Search outside databases for aliases for DNAJC7 gene

Previous GC identifers: GC17M039682 GC17M042284 GC17M040037 GC17M040501

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for DNAJC7:
DNAJC7 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate
molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3
distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a
glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling
a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM]

Gene Wiki entry for DNAJC7
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the DNAJC7 gene  

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q11.2

DNAJC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M037382:     (about GC identifiers)

Start:
37,381,982 bp from pter
End:
37,422,960 bp from pter
Size:
40,979 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000017.9  NT_010755.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: DNJC7_HUMAN, Q99615 (See protein sequence)
Recommended Name: DnaJ homolog subfamily C member 7  
Size: 494 amino acids; 56441 Da
Subunit: Interacts with the GAP domain of NF1

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001138238.1  NP_003306.2  


    ENSEMBL proteins: 
    ENSP00000313311 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (DNAJC7)
    Human Recombinant Proteins from Abnova (DNAJC7)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for DNAJC7: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for DNAJC7
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (DNAJC7), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (DNAJC7)
    Novus Biologicals Antibodies for DNAJC7

    Assays for DNAJC7: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/7 InterPro domains/families (see all 7 ):
     IPR015609 Hsp40/DnaJ_Rel
     IPR001440 TPR-1
     IPR011990 TPR-like_helical
     IPR001623 DnaJ_N
     IPR018253 Heat_shock_DnaJ_CS


       GeneDecks  DNAJC7 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q99615

    ProtoNet protein and cluster: Q99615

    UniProtKB/Swiss-Prot: DNJC7_HUMAN, Q99615
    Similarity: Contains 1 J domain
    Similarity: Contains 9 TPR repeats

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (DNAJC7)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (DNAJC7)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_003315

                  Applied Biosystems Silencer® siRNAs for DNAJC7

                  Sigma-Aldrich siRNA for DNAJC7  
                         Sigma-Aldrich shRNA for DNAJC7  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for DNAJC7
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001144766
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001144766
                                     untagged cDNA clones in CMV expression vector (see all 4): BC033772 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_003315

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031072 heat shock protein binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    2 Sigma-Aldrich "Your Favorite Gene" Pathways for  DNAJC7  (Your Favorite Gene powered by Ingenuity) 
     NRF2-mediated Oxidative Stress Response
     Xenobiotic Metabolism Signaling

       GeneDecks  DNAJC7 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  DNAJC7 


    5/10 Interacting proteins for DNAJC7 (ENSP000003133113 Q996152) via UniProtKB, MINT, and/or STRING (see all 10 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592MINT-48516
    MAP3K7IP1Q157502MINT-49180
    SMAD2Q157962MINT-61584
    SMAD9O151982MINT-62135
    RAD9AENSP000003113603STRING (score=.965)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457 protein folding TAS8836031
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for DNAJC7

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (DNAJC7)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (DNAJC7)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_003315

                  Sigma-Aldrich siRNA for DNAJC7  
                         Sigma-Aldrich shRNA for DNAJC7  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    REFSEQ mRNAs for DNAJC7 gene (2 alternative transcripts): 

    NM_001144766.1   NM_003315.2   


                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001144766
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001144766
                                     untagged cDNA clones in CMV expression vector (see all 4): BC033772 

    Additional cDNA sequence: 

    AB209834.1 AK093965.1 AK126179.1 AK291047.1 AK296602.1 AK298860.1 AK308016.1 AK316081.1 
    AL832812.1 BC003601.1 BC011837.2 BC033772.1 BX647209.1 CR594610.1 CR600431.1 CR609021.1 
    CR615988.1 CR620632.1 CR622093.1 U46571.1 

    24/34 DOTS entries (see all 34 ):

    DT.416333  DT.100699901  DT.100820692  DT.100683725  DT.99992907  DT.100820696  DT.91678481  DT.101977393 
    DT.407400  DT.92417479  DT.101961705  DT.86999870  DT.101955210  DT.75165174  DT.100820697  DT.102836836 
    DT.95165897  DT.100820693  DT.40106794  DT.40106795  DT.97854708  DT.120967377  DT.120967402  DT.120967419 

    24/357 AceView cDNA sequences (see all 357 ):

    CR594610 BP379055 BP360614 AA626252 BM854582 AW192070 AA351967 BQ707566 
    AA846510 BX345378 BM468104 BP378441 BI763741 BU688592 BM692686 BE794236 
    AA233346 AA639418 BI966782 CR620632 BQ953471 BP372220 BU681849 AL565274 

    highest scoring ESTs for DNAJC7:

    U46571 AU100176 BC003601 BC011837 BC033772 BE267568 BE269209 BE270044 BE560927 BG105985 

    Unigene Cluster for DNAJC7:

    DnaJ (Hsp40) homolog, subfamily C, member 7
    Hs.500156  [show with all ESTs]
    Unigene Representative Sequence: AK126179


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC7

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14
    SP1:        -     -           -                                                                           
    SP2:              -           -                                                                           
    SP3:                                                                                      -               
    SP4:                                                                    -                                 
    SP5:                    -                                                                                 

    About this scheme

    ECgene alternative splicing isoforms for DNAJC7

    1 Ensembl transcript including schematic representation:
    ENST00000316603  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    DNAJC7 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for DNAJC7

    1 / 2 / 3

    4 probe-sets matching DNAJC7 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    41800_s_at2, 3 U95-A 2 1.00 0.94 0.46 1.56 U46571 1.00 1.00 1.00 1

    33618_at*2, 3 U95-A 1 -- -- 0.98 0.47 W27885 0.20 1.00 0.72 1

    202416_at2, 3 U133-A 2 1.00 0.95 -- -- NM_003315 0.60 1.00 0.82 1

    202416_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AATATGGGTG

    SOURCE GeneReport for Unigene cluster: Hs.500156

    Expression variation in blood from EXPOLDB for DNAJC7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for DNAJC7 gene from 5/16 species (see all 16 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    DNAJC71   -- DnaJ (Hsp40) homolog, subfamily C, member 7 94.77(n)
    98.35(a)
    480519  XM_537639.2  XP_537639.2 
    cow
    (Bos taurus)
    DNAJC71   -- DnaJ (Hsp40) homolog, subfamily C, member 7 94.01(n)
    98.14(a)
    530254  XM_608719.3  XP_608719.3 
    rat
    (Rattus norvegicus)
    Dnajc71   -- DnaJ (Hsp40) homolog, subfamily C, member 7 91.25(n)
    97.31(a)
    303536  NM_213625.1  NP_998790.1 
    mouse
    (Mus musculus)
    Dnajc71, 5 11 (60.00 cM)5
    DnaJ (Hsp40) homolog, subfamily C, member 71, 5 91.46(n)1
    97.31(a)1
    563541  NM_019795.41  NP_062769.21 
     AB0288615  AI8359175  (see all 20)
    chicken
    (Gallus gallus)
    DNAJC71   -- DnaJ (Hsp40) homolog, subfamily C, member 7 83.19(n)
    93.72(a)
    428312  NM_001031502.1  NP_001026673.1 
    About this table        Species with no ortholog for DNAJC7

    ENSEMBL Gene Tree for DNAJC7
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for DNAJC7 gene
    DNAJC32  

    Pseudogenes
    2 related pseudogenes


    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/128 NCBI SNPs in DNAJC7 are shown (see all 128 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 66)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs11271821,2
    C,F37395828(-) TATCCA/GGAAGC 1 P/P syn11Minor allele frequency- G:0.18NA 72
    rs47967561,2
    A,C,F,H37409324(+) TTAAAT/CTACAG 1 -- int16Minor allele frequency- C:0.17EU EA NA 436
    rs80799581,2
    A,C,F,H37408993(+) TTCCAG/ATGTCA 1 -- int115Minor allele frequency- A:0.06EU EA WA NA 1400
    rs47967541,2
    A,C,F,H37407211(+) GGTTGT/CCTGAA 1 -- int17Minor allele frequency- C:0.25EU EA WA NA 548
    rs116526001,2
    A,C,F,H37404105(+) AGGTAT/CGGCTT 1 -- int14Minor allele frequency- C:0.27EU EA WA 420
    rs65036791,2
    A,C,F,H37400496(+) GCACCA/GGAAAA 1 -- int18Minor allele frequency- G:0.25EA NA EU WA 628
    rs72090121,2
    A,C,F,H37414849(+) CTCAAC/TACGGG 1 -- int17Minor allele frequency- T:0.05EU EA WA NA 562
    rs129523141,2
    C,F,H37398449(+) AGACCG/ACCTCT 1 -- int14Minor allele frequency- A:0.05EU EA WA 420
    --
    rs43786651,2
    A,F,H37397462(+) tcaagC/Tgatcc 1 -- int14Minor allele frequency- T:0.05EU EA WA 418
    rs129489701,2
    C,F,H37404364(+) TGGGTT/ATTGCC 1 -- int19Minor allele frequency- A:0.30EU WA NA EA 918
    About this table

    HapMap Linkage Disequilibrium images for DNAJC7 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 601964

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/13 PubMed articles for DNAJC7 gene (see all 13 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 7266 HGNC: 12392 AceView: DNAJC7 Ensembl:ENSG00000168259 euGenes: HUgn7266
    ECgene: DNAJC7 H-InvDB: DNAJC7
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for DNAJC7:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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     Predesigned and custom siRNAs for DNAJC7 Antibodies for DNAJC7
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for DNAJC7 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Antibodies for DNAJC7

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