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Aliases & Descriptions for DNAJC7
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases DANJC7 2 DJ11 2 TPR2 1 , 2 , 3 TTC2 2 , 3
Descriptions DnaJ (Hsp40) homolog, subfamily C, member 7 2 TPR repeat protein 2 3 Tetratricopeptide repeat protein 2 3 tetratricopeptide repeat domain 2 2
Search outside databases for aliases for DNAJC7 genePrevious GC identifers: GC17M039682 GC17M042284 GC17M040037 GC17M040501
Summaries for DNAJC7 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for DNAJC7 : DNAJC7 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulatemolecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; aglycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resemblinga zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM] Gene Wiki entry for DNAJC7
Genomic Location for DNAJC7
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the DNAJC7 gene Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q11.2 DNAJC7 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17M037382:
(about GC identifiers )
Start:
37,381,982 bp from pter
End:
37,422,960 bp from pter
Size:
40,979 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000017.9 NT_010755.15 Proteins for DNAJC7
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
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Abcam ,
Biochemical Assays by
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Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
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Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: DNJC7_HUMAN, Q99615 (See
protein sequence )Recommended Name: DnaJ homolog subfamily C member 7 Size : 494 amino acids; 56441 Da
Subunit : Interacts with the GAP domain of NF1
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001138238.1 NP_003306.2 ENSEMBL proteins: ENSP00000313311 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells Antibodies for DNAJC7: Assays for DNAJC7:
Protein
Domains/ Families for DNAJC7(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q99615 ProtoNet protein and cluster: Q99615
UniProtKB/Swiss-Prot: DNJC7_HUMAN, Q99615 Similarity : Contains 1 J domainSimilarity : Contains 9 TPR repeats
Gene Function for DNAJC7
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_003315 Applied Biosystems Silencer ® siRNAs for DNAJC7 Sigma-Aldrich siRNA for DNAJC7 Sigma-Aldrich shRNA for DNAJC7 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001144766                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001144766                                  untagged cDNA clones in CMV expression vector (see all 4 ): BC033772  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003315 1 Gene Ontology (GO) molecular function term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0031072 heat shock protein binding
IEA --
About this table
Pathways & Interactions for DNAJC7
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for DNAJC7 (Your Favorite Gene powered by Ingenuity) Gene Network CentralTM Interacting Genes and Proteins Network for DNAJC7 5/10 Interacting proteins for DNAJC7 (ENSP00000313311 3 Q99615 2 ) via UniProtKB, MINT, and/or STRING (see all 10
)About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
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Drugs & Compounds for DNAJC7 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Transcripts for DNAJC7(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_003315 Sigma-Aldrich siRNA for DNAJC7 Sigma-Aldrich shRNA for DNAJC7 Explore Sigma-Aldrich super-pooled esiRNAs
REFSEQ mRNAs for DNAJC7 gene (2 alternative transcripts): NM_001144766.1 NM_003315.2
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001144766                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001144766                                  untagged cDNA clones in CMV expression vector (see all 4 ): BC033772  
Additional cDNA sequence: AB209834.1 AK093965.1 AK126179.1 AK291047.1 AK296602.1 AK298860.1 AK308016.1 AK316081.1 AL832812.1 BC003601.1 BC011837.2 BC033772.1 BX647209.1 CR594610.1 CR600431.1 CR609021.1 CR615988.1 CR620632.1 CR622093.1 U46571.1
24/34 DOTS entries (see all 34
): DT.416333 DT.100699901 DT.100820692 DT.100683725 DT.99992907 DT.100820696 DT.91678481 DT.101977393 DT.407400 DT.92417479 DT.101961705 DT.86999870 DT.101955210 DT.75165174 DT.100820697 DT.102836836 DT.95165897 DT.100820693 DT.40106794 DT.40106795 DT.97854708 DT.120967377 DT.120967402 DT.120967419
24/357 AceView cDNA sequences (see all 357
):CR594610 BP379055 BP360614 AA626252 BM854582 AW192070 AA351967 BQ707566 AA846510 BX345378 BM468104 BP378441 BI763741 BU688592 BM692686 BE794236 AA233346 AA639418 BI966782 CR620632 BQ953471 BP372220 BU681849 AL565274
highest scoring ESTs for DNAJC7 :U46571 AU100176 BC003601 BC011837 BC033772 BE267568 BE269209 BE270044 BE560927 BG105985
Unigene Cluster for DNAJC7: DnaJ (Hsp40) homolog, subfamily C, member 7 Hs.500156 [show with all ESTs ] Unigene Representative Sequence: AK126179 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC7 ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 SP1 :   -   -     -                           SP2 :     -     -                           SP3 :                             -       SP4 :                       -             SP5 :       -                            
About this scheme ECgene alternative splicing isoforms for DNAJC7 1 Ensembl transcript including schematic representation : ENST00000316603
Expression for DNAJC7
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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DNAJC7 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for DNAJC7 1 / 2 / 3
4 probe-sets matching DNAJC7 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: AATATGGGTGSOURCE GeneReport for Unigene cluster: Hs.500156 Expression variation in blood from EXPOLDB for DNAJC7
Orthologs for DNAJC7
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
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Orthologs for DNAJC7 gene from 5/16 species (see all 16
)
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
dog (Canis familiaris)
DNAJC71
--
DnaJ (Hsp40) homolog, subfamily C, member 7
94.77(n) 98.35(a)
480519 XM_537639.2 XP_537639.2
cow (Bos taurus)
DNAJC71
--
DnaJ (Hsp40) homolog, subfamily C, member 7
94.01(n) 98.14(a)
530254 XM_608719.3 XP_608719.3
rat (Rattus norvegicus)
Dnajc71
--
DnaJ (Hsp40) homolog, subfamily C, member 7
91.25(n) 97.31(a)
303536 NM_213625.1 NP_998790.1
mouse (Mus musculus)
Dnajc71 , 5
11 (60.00 cM) 5
DnaJ (Hsp40) homolog, subfamily C, member 71, 5
91.46(n) 1 97.31(a) 1
56354 1 NM_019795.4 1 NP_062769.2 1 AB028861 5 AI835917 5 (see all 20 )
chicken (Gallus gallus)
DNAJC71
--
DnaJ (Hsp40) homolog, subfamily C, member 7
83.19(n) 93.72(a)
428312 NM_001031502.1 NP_001026673.1
About this table Species with no ortholog for DNAJC7 ENSEMBL Gene Tree for DNAJC7 Paralogs for DNAJC7 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for DNAJC7 gene DNAJC3 2 Pseudogenes 2 related pseudogenes
SNPs/Variants for DNAJC7 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for DNAJC7 (up to first 250kb)
Disorders & Mutations for DNAJC7
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 601964
Medical News for DNAJC7 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for DNAJC7 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/13 PubMed articles for DNAJC7 gene (see all 13
): Identification and characterization of two novel tetratricopeptide repeat-containing genes. (PubMed id 8836031) 1, 2, 3, 4 Murthy A.E.... Gusella J.F. (1996) Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455) 3, 4 Rush J.... Comb M.J. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PubMed id 11147971) 2, 3 Ohtsuka K. and Hata M. (2000) The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9. (PubMed id 11573955) 1, 3 Xiang S.L....Yamamoto K.C. (2001) Role of the cochaperone Tpr2 in Hsp90 chaperoning. (PubMed id 18620420) 3 Moffatt N.S....Toft D. (2008) The LIFEdb database in 2006. (PubMed id 16381901) 3 Mehrle A....Wiemann S. (2006) Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556) 3 Suzuki Y.... Sugano S. (2004) From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336) 3 Wiemann S....Poustka A. (2004) Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. (PubMed id 12853476) 3 Brychzy A....Obermann W.M. (2003)
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Genome Databases showing DNAJC7
(According to
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Ensembl ,
miRBase ,
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and/or
H-InvDB )
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Specialized Databases showing DNAJC7 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for DNAJC7 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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