Aliases for DNAJC7 Gene
External Ids for DNAJC7 Gene
Previous HGNC Symbols for DNAJC7 Gene
Previous GeneCards Identifiers for DNAJC7 Gene
This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chaperone proteins heat shock proteins 70 and 90 in an ATP-dependent manner and may function as a co-chaperone. Pseudogenes of this gene are found on chromosomes 1 and 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
GeneCards Summary for DNAJC7 Gene
DNAJC7 (DnaJ (Hsp40) Homolog, Subfamily C, Member 7) is a Protein Coding gene. GO annotations related to this gene include heat shock protein binding. An important paralog of this gene is DNAJC3.
UniProtKB/Swiss-Prot for DNAJC7 Gene
Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity).