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DNAJC6 Gene

protein-coding   GIFtS: 63
GCID: GC01P065714

DnaJ (Hsp40) Homolog, Subfamily C, Member 6

  See DNAJC6-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
DnaJ (Hsp40) Homolog, Subfamily C, Member 61 2     DnaJ (Hsp40) Homolog, Subfamily B, Member 62
auxilin1 2     Putative Tyrosine-Protein Phosphatase Auxilin2
DJC62 5     EC 3.1.3.483
PARK192 5     DnaJ Homolog Subfamily C Member 63
KIAA04733 5     

External Ids:    HGNC: 154691   Entrez Gene: 98292   Ensembl: ENSG000001166757   OMIM: 6083755   UniProtKB: O750613   
ORGUL members:         

Export aliases for DNAJC6 gene to outside databases

Previous GC identifers: GC01P065681 GC01P064649 GC01P065077 GC01P065090 GC01P065145 GC01P065442 GC01P065487 GC01P063839


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNAJC6 Gene:
DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone
activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino
acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain
containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 (PubMed 11147971)).(supplied by OMIM,
Mar 2008)

GeneCards Summary for DNAJC6 Gene:
DNAJC6 (DnaJ (Hsp40) homolog, subfamily C, member 6) is a protein-coding gene. Diseases associated with DNAJC6 include parkinson disease 19, juvenile-onset. GO annotations related to this gene include SH3 domain binding and protein tyrosine phosphatase activity. An important paralog of this gene is PTEN.

UniProtKB/Swiss-Prot: AUXI_HUMAN, O75061
Function: Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles (By
similarity)

Gene Wiki entry for DNAJC6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAJC6 gene promoter:
         HEN1   CHOP-10   LHX3b/Lhx3b   AML1a   FOXJ2 (long isoform)   COMP1   LHX3a/Lhx3a   FOXJ2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJC6 promoter sequence
   Search Chromatin IP Primers for DNAJC6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAJC6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31.3

DNAJC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJC6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P065714:  view genomic region     (about GC identifiers)

Start:
65,713,902 bp from pter      End:
65,881,552 bp from pter
Size:
167,651 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AUXI_HUMAN, O75061 (See protein sequence)
Recommended Name: Putative tyrosine-protein phosphatase auxilin  
Size: 913 amino acids; 99997 Da
Subunit: Interacts with HSPA8/HSC70. Interacts with CLTC. Interacts with AP2A2 (By similarity)
Sequence caution: Sequence=BAA32318.2; Type=Erroneous initiation;
Secondary accessions: B7Z3V8 D3DQ65 D3DQ66 Q32M66 Q4G0K1 Q5T614 Q5T615
Alternative splicing: 4 isoforms:  O75061-1   O75061-2   O75061-3   O75061-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DNAJC6: NX_O75061

Explore proteomics data for DNAJC6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DNAJC6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243793.1  NP_001243794.1  NP_055602.1  

    ENSEMBL proteins: 
     ENSP00000473821   ENSP00000378735   ENSP00000360108   ENSP00000263441  
    Reactome Protein details: O75061

    DNAJC6 Human Recombinant Protein Products:

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    Novus Biologicals DNAJC6 Proteins
    Novus Biologicals DNAJC6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DNAJC6

     
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    antibodies-online proteins for DNAJC6 (4 products) 

     
    antibodies-online peptides for DNAJC6

    DNAJC6 Antibody Products:

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    antibodies-online antibodies for DNAJC6 (12 products) 

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    antibodies-online kits for DNAJC6 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    4 InterPro protein domains:
     IPR014019 Phosphatase_tensin-typ
     IPR001623 DnaJ_domain
     IPR014020 Tensin_phosphatase_C2-dom
     IPR000008 C2_dom

    Graphical View of Domain Structure for InterPro Entry O75061

    ProtoNet protein and cluster: O75061

    UniProtKB/Swiss-Prot: AUXI_HUMAN, O75061
    Similarity: Contains 1 C2 tensin-type domain
    Similarity: Contains 1 J domain
    Similarity: Contains 1 phosphatase tensin-type domain


    Find genes that share domains with DNAJC6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AUXI_HUMAN, O75061
    Function: Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles (By
    similarity)
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Enzyme Number (IUBMB): EC 3.1.3.481

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding ----
    GO:0016791phosphatase activity ----
    GO:0017124SH3 domain binding IEA--
         
    Find genes that share ontologies with DNAJC6           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DNAJC6:
     Decreased focal adhesion (FA)   Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dnajc6):
     growth/size/body  mortality/aging  nervous system  reproductive system 

    Find genes that share phenotypes with DNAJC6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dnajc6tm1Legr for DNAJC6

       genOway: Develop your customized and physiologically relevant rodent model for DNAJC6

    miRNA
    Products:
        
    miRTarBase miRNAs that target DNAJC6:
    hsa-let-7c-5p (MIRT051833), hsa-let-7a-5p (MIRT052398), hsa-mir-26b-5p (MIRT030253)

    Block miRNA regulation of human, mouse, rat DNAJC6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAJC6 (see all 60):
    hsa-miR-21* hsa-miR-323-3p hsa-miR-2052 hsa-miR-607 hsa-miR-219-5p hsa-miR-342-3p hsa-miR-508-3p hsa-miR-223
    SwitchGear 3'UTR luciferase reporter plasmidDNAJC6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DNAJC6
    Predesigned siRNA for gene silencing in human, mouse, rat DNAJC6

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for DNAJC6

    Clone
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    OriGene ORF clones in mouse, rat for DNAJC6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DNAJC6 (NM_014787)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJC6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC6

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    Browse ESI BIO Cell Lines and PureStem Progenitors for DNAJC6 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC6

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12033) for DNAJC6 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    chloroplast1
    golgi apparatus1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    Find genes that share ontologies with DNAJC6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DNAJC6 About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    Lysosome Vesicle Biogenesis0.41
    Golgi Associated Vesicle Biogenesis0.89
    Membrane Trafficking0.32
    trans-Golgi Network Vesicle Budding0.89
    2Endocytosis
    Endocytosis


    Find genes that share SuperPaths with DNAJC6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for DNAJC6
        Golgi Associated Vesicle Biogenesis
    Lysosome Vesicle Biogenesis


    1 Kegg Pathway  (Kegg details for DNAJC6):
        Endocytosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJC6: 
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DNAJC6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNAJC6 (O750612, 3 ENSP000003787354) via UniProtKB, MINT, STRING, and/or I2D (see all 98)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AP2A2O949733, ENSP000004132344I2D: score=1 STRING: ENSP00000413234
    CLTCQ006103, ENSP000002691224I2D: score=2 STRING: ENSP00000269122
    BAG2O958162, ENSP000003597274MINT-8339158 STRING: ENSP00000359727
    YWHABP319463I2D: score=1 
    AP1M1ENSP000003889964STRING: ENSP00000388996
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006892post-Golgi vesicle-mediated transport TAS--
    GO:0016311dephosphorylation ----
    GO:0061024membrane organization TAS--

    Find genes that share ontologies with DNAJC6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNAJC6 (AUXI)

    1 HMDB Compound for DNAJC6    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DNAJC6 gene (3 alternative transcripts): 
    NM_001256864.1  NM_001256865.1  NM_014787.3  

    Unigene Cluster for DNAJC6:

    DnaJ (Hsp40) homolog, subfamily C, member 6
    Hs.647643  [show with all ESTs]
    Unigene Representative Sequence: NM_001256864
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000463018 ENST00000494710(uc001dcc.1) ENST00000395325(uc001dcd.1 uc010opc.1 uc001dce.1)
    ENST00000483402 ENST00000371069 ENST00000472787 ENST00000498720 ENST00000263441

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DNAJC6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAJC6 (see all 60):
    hsa-miR-21* hsa-miR-323-3p hsa-miR-2052 hsa-miR-607 hsa-miR-219-5p hsa-miR-342-3p hsa-miR-508-3p hsa-miR-223
    SwitchGear 3'UTR luciferase reporter plasmidDNAJC6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DNAJC6
    Predesigned siRNA for gene silencing in human, mouse, rat DNAJC6
    Clone
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    OriGene clones in human, mouse for DNAJC6 (see all 9)
    OriGene ORF clones in mouse, rat for DNAJC6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DNAJC6 (NM_014787)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJC6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC6
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJC6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAJC6
      QuantiTect SYBR Green Assays in human, mouse, rat DNAJC6
      QuantiFast Probe-based Assays in human, mouse, rat DNAJC6
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12033) for DNAJC6 

    Additional mRNA sequence: 

    AB007942.1 AK296408.1 BC051722.1 BC109279.2 BC109280.1 BX647203.1 

    9 DOTS entries:

    DT.447418  DT.100711969  DT.95113257  DT.306016  DT.121441552  DT.40298487  DT.97811096  DT.91746433 
    DT.97824641 

    Selected AceView cDNA sequences (see all 128):

    AI498157 Z40336 AW188058 BX499432 F05553 Z42974 R43149 BM023293 
    Z42434 AK123450 F04848 BX091342 N70935 BQ892331 AI458298 AA455940 
    F12912 Z39092 AA779850 AI809269 AI124694 F10517 BP362882 Z44405 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC6 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^
    SP1:              -     -                                         -     -                                                                                       
    SP2:                    -                                         -     -                                                                                       
    SP3:              -                                                                                                                                             
    SP4:                                                                                            -     -     -     -     -     -     -     -     -     -     -   
    SP5:                                                                                                                                                            

    ExUns: 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:  -     -     -                                 
    SP5:                                                


    ECgene alternative splicing isoforms for DNAJC6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNAJC6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAAGAATG
    DNAJC6 Expression
    About this image


    DNAJC6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Thymus (Hematopoietic System)
             Thymus
    DNAJC6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAJC6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.647643
        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJC6: 
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJC6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAJC6
    QuantiTect SYBR Green Assays in human, mouse, rat DNAJC6
    QuantiFast Probe-based Assays in human, mouse, rat DNAJC6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DNAJC6 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnajc61 , 5 DnaJ (Hsp40) homolog, subfamily C, member 61, 5 87.57(n)1
    93.08(a)1
      4 (46.89 cM)5
    726851  NM_001164583.11  NP_001158055.11 
     1014966485 
    chicken
    (Gallus gallus)
    Aves DNAJC61 DnaJ (Hsp40) homolog, subfamily C, member 6 74.12(n)
    77.31(a)
      424698  NM_001177415.1  NP_001170886.1 
    lizard
    (Anolis carolinensis)
    Reptilia DNAJC66
    DnaJ (Hsp40) homolog, subfamily C, member 6
    71(a)
    1 ↔ 1
    4(98239471-98300791)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dnajc61 DnaJ (Hsp40) homolog, subfamily C, member 6 69.98(n)
    71.62(a)
      100145185  NM_001126675.1  NP_001120147.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dnajc61 DnaJ (Hsp40) homolog, subfamily C, member 6 65.96(n)
    66.41(a)
      796345  XM_005165883.1  XP_005165940.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta aux6
    auxillin
    24(a)
    1 → many
    3R(37505-53244)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-836
    Protein TAG-83 (tag-83) mRNA, complete cds
    24(a)
    1 → many
    I(5600669-5603481) WBGene00006456


    ENSEMBL Gene Tree for DNAJC6 (if available)
    TreeFam Gene Tree for DNAJC6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNAJC6 gene
    PTEN2  TNS12  TPTE2  TENC12  GAK2  TPTE22  TNS42  TNS32  
    1 SIMAP similar gene for DNAJC6 using alignment to 3 protein entries:     AUXI_HUMAN (see all proteins):
    GAK

    Find genes that share paralogs with DNAJC6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNAJC6 (see all 2877)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs668491651,2
    C--63919682(+) GTATC-/AT/TA 
            
    AGGCC
    3 -- int11CSA 2
    rs66690841,2
    C,F,H--65728440(+) CTCTTC/TTGCTT 2 -- us2k13Minor allele frequency- T:0.05NS WA EA 340
    rs1924356491,2
    --65728459(+) TTGCCA/CTACTA 2 -- us2k10--------
    rs1844780411,2
    --65728562(+) ACAGAC/GAATGT 2 -- us2k10--------
    rs49952911,2
    H--65728566(+) agaatG/Tttttg 2 -- us2k14Minor allele frequency- T:0.00NS EA 412
    rs1507860171,2
    --65728689(+) GCCCCA/CCAAAG 2 -- us2k10--------
    rs4925831,2
    C,F,O,A,H--65728871(+) TCCACA/TGCCAA 2 -- us2k119Minor allele frequency- T:0.19NA NS EA WA CSA 779
    rs3761883731,2
    C--65728901(+) ACAAAA/TCTTAA 2 -- us2k10--------
    rs760939301,2
    C,F--65728976(+) AAGCTC/GTCACA 2 -- us2k11Minor allele frequency- G:0.03NA 120
    rs5153941,2
    C,F,O,A,H--65729058(+) GCCCAG/AGCAGT 2 -- us2k124Minor allele frequency- A:0.25NS EA NA WA CSA 2354

    HapMap Linkage Disequilibrium report for DNAJC6 (65713902 - 65881552 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DNAJC6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676423CNV Deletion23128226
    esv2749207CNV Deletion23290073
    nsv528808CNV Gain19592680
    nsv830070CNV Gain17160897

    Human Gene Mutation Database (HGMD): DNAJC6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAJC6
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAJC6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608375   
    OMIM disorders: 615528  
    1 disease for DNAJC6:    
    About MalaCards
    parkinson disease 19, juvenile-onset


    Find genes that share disorders with DNAJC6           About GenesLikeMe

    Genetic Association Database (GAD): DNAJC6
    Human Genome Epidemiology (HuGE) Navigator: DNAJC6 (2 documents)

    Export disorders for DNAJC6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNAJC6 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with DNAJC6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2, 3 Seki N.... Ohara O. (DNA Res. 1997)
    2. A genome-wide association study of the Protein C anticoagulant pathway. (PubMed id 22216198)1, 4 Athanasiadis G....Soria J.M. (PLoS ONE 2011)
    3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PubMed id 11147971)1, 3 Ohtsuka K. and Hata M. (Cell Stress Chaperones 2000)
    8. DNAJC6 is responsible for juvenile parkinsonism with phenotypic variability. (PubMed id 23211418)1 KAProA9lu A.8....Tolun A. (amp 2013)
    9. Dynamic protein-protein interaction wiring of the human spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (Mol. Cell 2012)
    10. Homozygous deletion of an 80 kb region comprising part of DNAJC6 and LEPR genes on chromosome 1P31.3 is associated with early onset obesity, mental retardation and epilepsy. (PubMed id 22647716)1 Vauthier V....Dam J. (Mol. Genet. Metab. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9829 HGNC: 15469 AceView: DNAJC6 Ensembl:ENSG00000116675 euGenes: HUgn9829
    ECgene: DNAJC6 Kegg: 9829 H-InvDB: DNAJC6

    (According to HUGE)
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    HUGE: KIAA0473

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DNAJC6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNAJC6 gene:
    Search GeneIP for patents involving DNAJC6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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