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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DNAJC6 Gene

protein-coding   GIFtS: 62
GCID: GC01P065714

DnaJ (Hsp40) Homolog, Subfamily C, Member 6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DnaJ (Hsp40) Homolog, Subfamily C, Member 61 2     KIAA04733 5
auxilin1 2     DnaJ (Hsp40) Homolog, Subfamily B, Member 62
DnaJ Homolog Subfamily C Member 62 3     Putative Tyrosine-Protein Phosphatase Auxilin2
DJC62 5     EC 3.1.3.483

External Ids:    HGNC: 154691   Entrez Gene: 98292   Ensembl: ENSG000001166757   OMIM: 6083755   UniProtKB: O750613   

Export aliases for DNAJC6 gene to outside databases

Previous GC identifers: GC01P065681 GC01P064649 GC01P065077 GC01P065090 GC01P065145 GC01P065442 GC01P065487 GC01P063839


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DNAJC6 Gene:
DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone
activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino
acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain
containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 (PubMed 11147971)).(supplied by OMIM,
Mar 2008)

GeneCards Summary for DNAJC6 Gene: 
DNAJC6 (DnaJ (Hsp40) homolog, subfamily C, member 6) is a protein-coding gene. Diseases associated with DNAJC6 include mental retardation epilepsy, and cowden disease, and among its related super-pathways are Clathrin derived vesicle budding and Translocation of GLUT4 to the Plasma Membrane. GO annotations related to this gene include SH3 domain binding and heat shock protein binding. An important paralog of this gene is PTEN.

UniProtKB/Swiss-Prot: AUXI_HUMAN, O75061
Function: Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles (By
similarity)

Gene Wiki entry for DNAJC6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DNAJC6 gene promoter:
         HEN1   CHOP-10   LHX3b/Lhx3b   AML1a   FOXJ2 (long isoform)   COMP1   LHX3a/Lhx3a   FOXJ2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJC6 promoter sequence
   Search SABiosciences Chromatin IP Primers for DNAJC6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJC6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31.3

DNAJC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJC6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P065714:  view genomic region     (about GC identifiers)

Start:
65,713,902 bp from pter      End:
65,881,552 bp from pter
Size:
167,651 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AUXI_HUMAN, O75061 (See protein sequence)
Recommended Name: Putative tyrosine-protein phosphatase auxilin  
Size: 913 amino acids; 99997 Da
Subunit: Interacts with HSPA8/HSC70. Interacts with CLTC. Interacts with AP2A2 (By similarity)
Sequence caution: Sequence=BAA32318.2; Type=Erroneous initiation;
Secondary accessions: B7Z3V8 D3DQ65 D3DQ66 Q32M66 Q4G0K1 Q5T614 Q5T615
Alternative splicing: 4 isoforms:  O75061-1   O75061-2   O75061-3   O75061-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DNAJC6: NX_O75061

Explore proteomics data for DNAJC6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75061

  • DNAJC6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DNAJC6 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001243793.1  NP_001243794.1  NP_055602.1  

    ENSEMBL proteins: 
     ENSP00000473821   ENSP00000378735   ENSP00000360108   ENSP00000263441  
    Reactome Protein details: O75061
    Human Recombinant Protein Products for DNAJC6: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DNAJC6 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    DNAJC6 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    4 InterPro protein domains:
     IPR014019 Phosphatase_tensin-typ
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR001623 DnaJ_domain
     IPR014020 Tensin_phosphatase_C2-dom

    Graphical View of Domain Structure for InterPro Entry O75061

    ProtoNet protein and cluster: O75061

    UniProtKB/Swiss-Prot: AUXI_HUMAN, O75061
    Similarity: Contains 1 C2 tensin-type domain
    Similarity: Contains 1 J domain
    Similarity: Contains 1 phosphatase tensin-type domain


    DNAJC6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AUXI_HUMAN, O75061
    Function: Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles (By
    similarity)
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Enzyme Number (IUBMB): EC 3.1.3.481

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding ----
    GO:0016791phosphatase activity ----
    GO:0017124SH3 domain binding IEA--
         
    DNAJC6 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DNAJC6:
     Decreased focal adhesion (FA)   Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dnajc6):
     growth/size  mortality/aging  nervous system  reproductive system 

    DNAJC6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dnajc6tm1Legr for DNAJC6

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DNAJC6 
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    SwitchGear 3'UTR luciferase reporter plasmidDNAJC6 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DNAJC6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    trans-Golgi Network Vesicle Budding0.89
    Golgi Associated Vesicle Biogenesis0.89
    Lysosome Vesicle Biogenesis0.39
    2Membrane Trafficking
    Membrane Trafficking0.32
    3Endocytosis
    Endocytosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5        Reactome Pathways for DNAJC6
        Membrane Trafficking
    Clathrin derived vesicle budding
    Golgi Associated Vesicle Biogenesis
    trans-Golgi Network Vesicle Budding
    Lysosome Vesicle Biogenesis


    1         Kegg Pathway  (Kegg details for DNAJC6):
        Endocytosis


    DNAJC6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNAJC6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for DNAJC6 (O750612, 3 ENSP000003787354) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AP2A2O949733, ENSP000004132344I2D: score=1 STRING: ENSP00000413234
    CLTCQ006103, ENSP000002691224I2D: score=2 STRING: ENSP00000269122
    BAG2O958162, ENSP000003597274MINT-8339158 STRING: ENSP00000359727
    YWHABP319463I2D: score=1 
    AP1M1ENSP000003889964STRING: ENSP00000388996
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006892post-Golgi vesicle-mediated transport TAS--
    GO:0016311dephosphorylation ----

    DNAJC6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DNAJC6 (AUXI)

    1 HMDB Compound for DNAJC6    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--

    Search CenterWatch for drugs/clinical trials and news about DNAJC6 / AUXI

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DNAJC6 gene (3 alternative transcripts): 
    NM_001256864.1  NM_001256865.1  NM_014787.3  

    Unigene Cluster for DNAJC6:

    DnaJ (Hsp40) homolog, subfamily C, member 6
    Hs.647643  [show with all ESTs]
    Unigene Representative Sequence: NM_001256864
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000463018 ENST00000494710(uc001dcc.1) ENST00000395325(uc001dcd.1 uc010opc.1 uc001dce.1)
    ENST00000483402 ENST00000371069 ENST00000472787 ENST00000498720 ENST00000263441

    miRNA
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    hsa-miR-21* hsa-miR-323-3p hsa-miR-2052 hsa-miR-607 hsa-miR-219-5p hsa-miR-342-3p hsa-miR-508-3p hsa-miR-223
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    Additional mRNA sequence: 

    AB007942.1 AK296408.1 BC051722.1 BC109279.2 BC109280.1 BX647203.1 

    9 DOTS entries:

    DT.447418  DT.100711969  DT.95113257  DT.306016  DT.121441552  DT.40298487  DT.97811096  DT.91746433 
    DT.97824641 

    24/128 AceView cDNA sequences (see all 128):

    AK123450 AI458298 Z39092 F05553 AI809269 Z42974 BQ892331 F04848 
    AI124694 Z40336 Z42434 R43149 AA455940 AL120661 BP362882 AA779850 
    F10517 BX091342 BX499432 Z38527 N70935 Z44405 AI498157 AI753668 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC6 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^
    SP1:              -     -                                         -     -                                                                                       
    SP2:                    -                                         -     -                                                                                       
    SP3:              -                                                                                                                                             
    SP4:                                                                                            -     -     -     -     -     -     -     -     -     -     -   
    SP5:                                                                                                                                                            

    ExUns: 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:  -     -     -                                 
    SP5:                                                


    ECgene alternative splicing isoforms for DNAJC6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DNAJC6 expression in normal human tissues (normalized intensities)      DNAJC6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAAGAATG
    DNAJC6 Expression
    About this image


    DNAJC6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Thalamus
             Globus Pallidus   
     
     Neural Tube (Nervous System)    fully expand to see all 8 entries
             Telencephalon
             spinal cord/lateral wall/marginal layer   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 5 entries
             PERIPHERAL NERVOUS SYSTEM   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Umbilical cord blood-derived hematopoietic stem cells
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             spinal/ganglion/dorsal root ganglion   

    See DNAJC6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DNAJC6

    SOURCE GeneReport for Unigene cluster: Hs.647643
        SABiosciences Expression via Pathway-Focused PCR Arrays including DNAJC6: 
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DNAJC6 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnajc61 , 5 DnaJ (Hsp40) homolog, subfamily C, member 61, 5 87.44(n)1
    93.63(a)1
      4 (46.89 cM)5
    726851  NM_001164583.11  NP_001158055.11 
     1014966485 
    chicken
    (Gallus gallus)
    Aves DNAJC61 DnaJ (Hsp40) homolog, subfamily C, member 6 73.83(n)
    76.96(a)
      424698  NM_001177415.1  NP_001170886.1 
    lizard
    (Anolis carolinensis)
    Reptilia DNAJC66
    DnaJ (Hsp40) homolog, subfamily C, member 6
    70(a)
    1 ↔ 1
    4(98239471-98300791)
    zebrafish
    (Danio rerio)
    Actinopterygii dnajc61 DnaJ (Hsp40) homolog, subfamily C, member 6 65.97(n)
    66.67(a)
      796345  XM_001336637.2  XP_001336673.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta aux6
    auxillin
    22(a)
    1 → many
    3R(37505-53244)
    worm
    (Caenorhabditis elegans)
    Secernentea dnj-256
    Protein DNJ-25, isoform a
    23(a)
    1 → many
    V(20729948-20744340)


    ENSEMBL Gene Tree for DNAJC6 (if available)
    TreeFam Gene Tree for DNAJC6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DNAJC6 gene
    PTEN2  TNS12  TPTE2  TNS42  TNS32  TENC12  GAK2  TPTE22  
    1 SIMAP similar gene for DNAJC6 using alignment to 2 protein entries:     AUXI_HUMAN (see all proteins):
    GAK

    DNAJC6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2877 SNPs in DNAJC6 are shown (see all 2877)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs668491651,2
    C--63919682(+) GTATC-/AT/TA 
            
    AGGCC
    3 -- int11CSA 2
    rs66690841,2
    C,F,H--65728440(+) CTCTTC/TTGCTT 2 -- us2k13Minor allele frequency- T:0.05NS WA EA 340
    rs1924356491,2
    --65728459(+) TTGCCA/CTACTA 2 -- us2k10--------
    rs1844780411,2
    --65728562(+) ACAGAC/GAATGT 2 -- us2k10--------
    rs49952911,2
    H--65728566(+) agaatG/Tttttg 2 -- us2k14Minor allele frequency- T:0.00NS EA 412
    rs1507860171,2
    --65728689(+) GCCCCA/CCAAAG 2 -- us2k10--------
    rs4925831,2
    C,F,O,A,H--65728871(+) TCCACA/TGCCAA 2 -- us2k119Minor allele frequency- T:0.19NA NS EA WA CSA 779
    rs3761883731,2
    C--65728901(+) ACAAAA/TCTTAA 2 -- us2k10--------
    rs760939301,2
    C,F--65728976(+) AAGCTC/GTCACA 2 -- us2k11Minor allele frequency- G:0.03NA 120
    rs5153941,2
    C,F,O,A,H--65729058(+) GCCCAG/AGCAGT 2 -- us2k124Minor allele frequency- A:0.25NS EA NA WA CSA 2354

    HapMap Linkage Disequilibrium report for DNAJC6 (65713902 - 65881552 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DNAJC6:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676423CNV Deletion23128226
    esv2749207CNV Deletion23290073
    nsv528808CNV Gain19592680
    nsv830070CNV Gain17160897


    Human Gene Mutation Database (HGMD): DNAJC6
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAJC6
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAJC6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608375    OMIM disorders: --

    5 diseases for DNAJC6:    About MalaCards
    mental retardation epilepsy    cowden disease    mental retardation    schizophrenia
    neuronitis


    DNAJC6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DNAJC6
    Human Genome Epidemiology (HuGE) Navigator: DNAJC6 (2 documents)

    Export disorders for DNAJC6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DNAJC6 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with DNAJC6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2, 3 Seki N.... Ohara O. (1997)
    2. A genome-wide association study of the Protein C antic oagulant pathway. (PubMed id 22216198)1, 4 Athanasiadis G....Soria J.M. (2011)
    3. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (2010)
    4. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (2010)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PubMed id 11147971)1, 3 Ohtsuka K. and Hata M. (2000)
    8. DNAJC6 is responsible for juvenile parkinsonism with p henotypic variability. (PubMed id 23211418)1 Koroglu C....Tolun A. (2013)
    9. Dynamic protein-protein interaction wiring of the huma n spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (2012)
    10. Homozygous deletion of an 80 kb region comprising part of DNAJC6 and LEPR genes on chromosome 1P31.3 is associated with early onset ob esity, mental retardation and epilepsy. (PubMed id 22647716)1 Vauthier V....Dam J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9829 HGNC: 15469 AceView: DNAJC6 Ensembl:ENSG00000116675 euGenes: HUgn9829
    ECgene: DNAJC6 Kegg: 9829 H-InvDB: DNAJC6

    (According to HUGE)
    About This Section
    HUGE: KIAA0473

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DNAJC6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DNAJC6 gene:
    Search GeneIP for patents involving DNAJC6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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