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Aliases for DNAJC6 Gene

Aliases for DNAJC6 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C6 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 6 2 3
  • Auxilin 2 3
  • DnaJ (Hsp40) Homolog, Subfamily B, Member 6 3
  • DnaJ Homolog Subfamily C Member 6 4
  • EC 4
  • KIAA0473 4
  • PARK19 3
  • DJC6 3

External Ids for DNAJC6 Gene

Previous GeneCards Identifiers for DNAJC6 Gene

  • GC01P065681
  • GC01P064649
  • GC01P065077
  • GC01P065090
  • GC01P065145
  • GC01P065442
  • GC01P065487
  • GC01P063839
  • GC01P065714

Summaries for DNAJC6 Gene

Entrez Gene Summary for DNAJC6 Gene

  • DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM, Mar 2008]

GeneCards Summary for DNAJC6 Gene

DNAJC6 (DnaJ Heat Shock Protein Family (Hsp40) Member C6) is a Protein Coding gene. Diseases associated with DNAJC6 include Parkinson Disease 19, Juvenile-Onset and Atypical Juvenile Parkinsonism. Among its related pathways are Clathrin derived vesicle budding and Vesicle-mediated transport. GO annotations related to this gene include phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is TNS1.

UniProtKB/Swiss-Prot for DNAJC6 Gene

  • Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity).

Gene Wiki entry for DNAJC6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC6 Gene

Genomics for DNAJC6 Gene

Regulatory Elements for DNAJC6 Gene

Enhancers for DNAJC6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DNAJC6 on UCSC Golden Path with GeneCards custom track

Genomic Location for DNAJC6 Gene

65,248,148 bp from pter
65,415,869 bp from pter
167,722 bases
Plus strand

Genomic View for DNAJC6 Gene

Genes around DNAJC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC6 Gene

Proteins for DNAJC6 Gene

  • Protein details for DNAJC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative tyrosine-protein phosphatase auxilin
    Protein Accession:
    Secondary Accessions:
    • B7Z3V8
    • D3DQ65
    • D3DQ66
    • Q32M66
    • Q4G0K1
    • Q5T614
    • Q5T615

    Protein attributes for DNAJC6 Gene

    913 amino acids
    Molecular mass:
    99997 Da
    Quaternary structure:
    • Interacts with HSPA8/HSC70. Interacts with CLTC. Interacts with AP2A2 (By similarity).
    • Sequence=BAA32318.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAJC6 Gene


neXtProt entry for DNAJC6 Gene

Proteomics data for DNAJC6 Gene at MOPED

Post-translational modifications for DNAJC6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJC6 Gene

No data available for DME Specific Peptides for DNAJC6 Gene

Domains & Families for DNAJC6 Gene

Suggested Antigen Peptide Sequences for DNAJC6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2 tensin-type domain.
  • Contains 1 C2 tensin-type domain.
  • Contains 1 J domain.
  • Contains 1 phosphatase tensin-type domain.
genes like me logo Genes that share domains with DNAJC6: view

Function for DNAJC6 Gene

Molecular function for DNAJC6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity).

Enzyme Numbers (IUBMB) for DNAJC6 Gene

genes like me logo Genes that share phenotypes with DNAJC6: view

Human Phenotype Ontology for DNAJC6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DNAJC6 Gene

MGI Knock Outs for DNAJC6:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for DNAJC6 Gene

Localization for DNAJC6 Gene

Subcellular locations from

Jensen Localization Image for DNAJC6 Gene COMPARTMENTS Subcellular localization image for DNAJC6 gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 3
endosome 1
golgi apparatus 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DNAJC6 Gene

Pathways & Interactions for DNAJC6 Gene

genes like me logo Genes that share pathways with DNAJC6: view

Pathways by source for DNAJC6 Gene

Gene Ontology (GO) - Biological Process for DNAJC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with DNAJC6: view

No data available for SIGNOR curated interactions for DNAJC6 Gene

Drugs & Compounds for DNAJC6 Gene

(3) Additional Compounds for DNAJC6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with DNAJC6: view

Transcripts for DNAJC6 Gene

Unigene Clusters for DNAJC6 Gene

DnaJ (Hsp40) homolog, subfamily C, member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^
SP1: - - - -
SP2: - - -
SP3: -
SP4: - - - - - - - - - - -

ExUns: 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b
SP4: - - -

Relevant External Links for DNAJC6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJC6 Gene

mRNA expression in normal human tissues for DNAJC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAJC6 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.7), Brain - Anterior cingulate cortex (BA24) (x5.6), Brain - Substantia nigra (x4.6), Brain - Hypothalamus (x4.5), Brain - Spinal cord (cervical c-1) (x4.3), and Brain - Hippocampus (x4.2).

Protein differential expression in normal tissues from HIPED for DNAJC6 Gene

This gene is overexpressed in Frontal cortex (30.9), Brain (19.0), and Fetal Brain (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DNAJC6 Gene

SOURCE GeneReport for Unigene cluster for DNAJC6 Gene Hs.647643

mRNA Expression by UniProt/SwissProt for DNAJC6 Gene

Tissue specificity: Expressed in various brain regions, including cerebellum, corpus callosum, cortex, striatum, brainstem, pons, putamen, spinal cord and substantia nigra. Very low expression in non-neural tissues such as leukocytes, liver, adipose tissue, skeletal muscle and bone marrow.
genes like me logo Genes that share expression patterns with DNAJC6: view

Protein tissue co-expression partners for DNAJC6 Gene

- Elite partner

Primer Products

Orthologs for DNAJC6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNAJC6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DNAJC6 35
  • 92.2 (n)
  • 95.6 (a)
  • 96 (a)
(Canis familiaris)
Mammalia DNAJC6 35
  • 91.99 (n)
  • 94.64 (a)
  • 95 (a)
(Mus musculus)
Mammalia Dnajc6 35
  • 87.57 (n)
  • 93.08 (a)
Dnajc6 16
Dnajc6 36
  • 93 (a)
(Pan troglodytes)
Mammalia DNAJC6 35
  • 99.28 (n)
  • 99.59 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Dnajc6 35
  • 87.65 (n)
  • 93.81 (a)
(Monodelphis domestica)
Mammalia DNAJC6 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia DNAJC6 36
  • 42 (a)
(Gallus gallus)
Aves DNAJC6 35
  • 74.12 (n)
  • 77.31 (a)
  • 75 (a)
(Anolis carolinensis)
Reptilia DNAJC6 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc6 35
  • 69.98 (n)
  • 71.62 (a)
(Danio rerio)
Actinopterygii dnajc6 35
  • 65.96 (n)
  • 66.41 (a)
dnajc6 36
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta aux 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea tag-83 36
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWA2 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10856 36
  • 25 (a)
Species with no ortholog for DNAJC6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC6 Gene

Gene Tree for DNAJC6 (if available)
Gene Tree for DNAJC6 (if available)

Paralogs for DNAJC6 Gene

Paralogs for DNAJC6 Gene

(1) SIMAP similar genes for DNAJC6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DNAJC6: view

Variants for DNAJC6 Gene

Sequence variations from dbSNP and Humsavar for DNAJC6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4915691 - 65,401,836(+) TCAAA(A/G)CAAAC reference, missense
rs488814 -- 65,272,824(+) cgtga(A/G)ccact intron-variant
rs492583 -- 65,263,188(+) TCCAC(A/T)GCCAA intron-variant, upstream-variant-2KB
rs539502 -- 65,253,509(+) CCGTG(C/T)CCGAT intron-variant, upstream-variant-2KB
rs543192 -- 65,259,188(+) TAACT(A/G)GCCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC6 Gene

Variant ID Type Subtype PubMed ID
esv2676423 CNV Deletion 23128226
esv2749207 CNV Deletion 23290073
nsv830070 CNV Gain 17160897
nsv528808 CNV Gain 19592680

Variation tolerance for DNAJC6 Gene

Residual Variation Intolerance Score: 4.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.78; 47.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC6 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC6 Gene

Disorders for DNAJC6 Gene

MalaCards: The human disease database

(4) MalaCards diseases for DNAJC6 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
parkinson disease 19, juvenile-onset
  • park19
atypical juvenile parkinsonism
dnajc6-related parkinson disease
  • parkinson disease 19, juvenile-onset
spinocerebellar ataxia 5
  • spinocerebellar ataxia type 5
- elite association - COSMIC cancer census association via MalaCards


  • Parkinson disease 19, juvenile-onset (PARK19) [MIM:615528]: A juvenile form of Parkinson disease, a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK19 is characterized by onset of parkinsonian symptoms in the first or second decade of life. Some patients may have additional neurologic features, including mental retardation and seizures. {ECO:0000269 PubMed:22563501, ECO:0000269 PubMed:23211418}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for DNAJC6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DNAJC6: view

No data available for Genatlas for DNAJC6 Gene

Publications for DNAJC6 Gene

  1. A deleterious mutation in DNAJC6 encoding the neuronal-specific clathrin-uncoating co-chaperone auxilin, is associated with juvenile parkinsonism. (PMID: 22563501) Edvardson S. … Elpeleg O. (PLoS ONE 2012) 2 3 4 67
  2. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K. … Hata M. (Cell Stress Chaperones 2000) 2 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. DNAJ mutations are rare in Chinese Parkinson's disease patients and controls. (PMID: 24126164) Foo J.N. … Tan E.K. (Neurobiol. Aging 2014) 3
  5. Genetics of Parkinson's disease--state of the art, 2013. (PMID: 24262182) Bonifati V. (Parkinsonism Relat. Disord. 2014) 3

Products for DNAJC6 Gene

Sources for DNAJC6 Gene