Aliases for DNAJC6 Gene
External Ids for DNAJC6 Gene
Previous GeneCards Identifiers for DNAJC6 Gene
DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM, Mar 2008]
GeneCards Summary for DNAJC6 Gene
DNAJC6 (DnaJ Heat Shock Protein Family (Hsp40) Member C6) is a Protein Coding gene. Diseases associated with DNAJC6 include Parkinson Disease 19A, Juvenile-Onset and Atypical Juvenile Parkinsonism. Among its related pathways are Clathrin derived vesicle budding and Clathrin-mediated endocytosis. GO annotations related to this gene include phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is GAK.
UniProtKB/Swiss-Prot for DNAJC6 Gene
Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity).