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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DNAJC5G Gene

protein-coding   GIFtS: 45
GCID: GC02P027498

DnaJ (Hsp40) Homolog, Subfamily C, Member 5 Gamma

  Search for DNAJC5G
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DnaJ (Hsp40) Homolog, Subfamily C, Member 5 Gamma1 2     Gamma Cysteine String Protein2
Cysteine String Protein-Gamma2 3     gamma-CSP2
CSP-gamma2 3     Gamma-Cysteine String Protein2
DnaJ Homolog Subfamily C Member 5G2     

External Ids:    HGNC: 248441   Entrez Gene: 2851262   Ensembl: ENSG000001637937   OMIM: 6139465   UniProtKB: Q8N7S23   

Export aliases for DNAJC5G gene to outside databases

Previous GC identifers: GC02P027473 GC02P027412 GC02P027239


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DNAJC5G Gene: 
DNAJC5G (DnaJ (Hsp40) homolog, subfamily C, member 5 gamma) is a protein-coding gene. GO annotations related to this gene include unfolded protein binding and heat shock protein binding. An important paralog of this gene is DNAJB4.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DNAJC5G gene promoter:
         NF-1   Bach2   POU3F2 (N-Oct-5a)   Nkx2-5   POU3F2   LCR-F1   E47   Arnt   CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJC5G promoter sequence
   Search SABiosciences Chromatin IP Primers for DNAJC5G

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJC5G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23

DNAJC5G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJC5G gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P027498:  view genomic region     (about GC identifiers)

Start:
27,498,289 bp from pter      End:
27,504,367 bp from pter
Size:
6,079 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DNJ5G_HUMAN, Q8N7S2 (See protein sequence)
Recommended Name: DnaJ homolog subfamily C member 5G  
Size: 189 amino acids; 21433 Da
Subcellular location: Membrane; Lipid-anchor (By similarity)
Secondary accessions: Q53SY5 Q8IYQ4 Q96RJ8

Explore the universe of human proteins at neXtProt for DNAJC5G: NX_Q8N7S2

Explore proteomics data for DNAJC5G at MOPED 

Post-translational modifications:

  • UniProtKB: Palmitoylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N7S2

  • DNAJC5G Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DNAJC5G Protein Expression
    REFSEQ proteins: NP_775921.1  
    ENSEMBL proteins: 
     ENSP00000296097   ENSP00000400382   ENSP00000384305   ENSP00000385829   ENSP00000385533  

    Human Recombinant Protein Products for DNAJC5G: 
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    Novus Biologicals DNAJC5G Protein
    Novus Biologicals DNAJC5G Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane IEA--

    DNAJC5G for ontologies           About GeneDecksing



    DNAJC5G Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    2 InterPro protein domains:
     IPR001623 DnaJ_domain
     IPR018253 DnaJ_domain_CS

    Graphical View of Domain Structure for InterPro Entry Q8N7S2

    ProtoNet protein and cluster: Q8N7S2

    UniProtKB/Swiss-Prot: DNJ5G_HUMAN, Q8N7S2
    Similarity: Contains 1 J domain


    DNAJC5G for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         2 GenomeRNAi human phenotypes for DNAJC5G:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         1 MGI phenotypic allele for Dnajc5g (no phenotypes)

    DNAJC5G for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DNAJC5G 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DNAJC5G

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DNAJC5G 
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    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate DNAJC5G:
    hsa-miR-485-5p hsa-miR-4268 hsa-miR-1285 hsa-miR-888* hsa-miR-504 hsa-miR-612 hsa-miR-3658 hsa-miR-593*
    SwitchGear 3'UTR luciferase reporter plasmidDNAJC5G 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC5G


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DNAJC5G About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for DNAJC5G):
        Protein processing in endoplasmic reticulum


    DNAJC5G for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNAJC5G

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for DNAJC5G (ENSP000002960974) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000226704ENSP000004091514STRING: ENSP00000409151
    ENSG00000234475ENSP000004089074STRING: ENSP00000408907
    HSPA2ENSP000002472074STRING: ENSP00000247207
    HSPA6ENSP000003102194STRING: ENSP00000310219
    HSPA8ENSP000002273784STRING: ENSP00000227378
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DNAJC5G (DNJ5G)

    Search CenterWatch for drugs/clinical trials and news about DNAJC5G / DNJ5G

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DNAJC5G gene: 
    NM_173650.1  

    Unigene Cluster for DNAJC5G:

    DnaJ (Hsp40) homolog, subfamily C, member 5 gamma
    Hs.116303  [show with all ESTs]
    Unigene Representative Sequence: NM_173650
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296097(uc002rjl.1 uc010yli.1) ENST00000420191 ENST00000402462(uc002rjm.1)
    ENST00000404433 ENST00000406962 ENST00000460358
    miRNA
    Products:
         
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate DNAJC5G:
    hsa-miR-485-5p hsa-miR-4268 hsa-miR-1285 hsa-miR-888* hsa-miR-504 hsa-miR-612 hsa-miR-3658 hsa-miR-593*
    SwitchGear 3'UTR luciferase reporter plasmidDNAJC5G 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DNAJC5G
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of DNAJC5G 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJC5G
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAJC5G
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAJC5G

    Additional mRNA sequence: 

    AF368277.1 AK097736.1 AK302239.1 BC035194.2 

    4 DOTS entries:

    DT.97824169  DT.100019099  DT.100744717  DT.91740278 

    15 AceView cDNA sequences:

    AF368277 AK097736 NM_173650 BX492846 AA629078 CD654578 BC035194 BX280646 
    BI755946 AI183575 AI040950 BI459532 BF376675 BF376661 BF511649 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC5G    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4
    SP1:                                    
    SP2:                                    


    ECgene alternative splicing isoforms for DNAJC5G

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DNAJC5G expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DNAJC5G Expression
    About this image


    See DNAJC5G Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DNAJC5G

    SOURCE GeneReport for Unigene cluster: Hs.116303

    UniProtKB/Swiss-Prot: DNJ5G_HUMAN, Q8N7S2
    Tissue specificity: Testis specific

        SABiosciences Expression via Pathway-Focused PCR Array including DNAJC5G: 
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC5G

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DNAJC5G gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnajc5g1 , 5 DnaJ (Hsp40) homolog, subfamily C, member 5 gamma1, 5 75.76(n)1
    67.27(a)1
      5 (17.03 cM)5
    2310981  NM_177677.31  NP_808345.11 
     311083195 
    zebrafish
    (Danio rerio)
    Actinopterygii dnajc5ga6
    dnajc5gb6
    DnaJ (Hsp40) homolog, subfamily C, member 5 gamma ...
    DnaJ (Hsp40) homolog, subfamily C, member 5 gamma ...
    40(a)
    38(a)
    1 ↔ many
    1 ↔ many
    20(38788662-38812050)
    17(6253923-6272240)
    fruit fly
    (Drosophila melanogaster)
    Insecta Csp6
    Cysteine string protein
    32(a)
    1 → many
    3L(22260361-22266845)
    worm
    (Caenorhabditis elegans)
    Secernentea dnj-146
    Protein DNJ-14, isoform a
    27(a)
    1 → many
    X(4709867-4711744)


    ENSEMBL Gene Tree for DNAJC5G (if available)
    TreeFam Gene Tree for DNAJC5G (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DNAJC5G gene
    DNAJB42  DNAJB52  DNAJB132  DNAJB22  DNAJB92  DNAJB62  DNAJB12  DNAJB72  
    DNAJC5B2  DNAJC52  DNAJB82  
    11 SIMAP similar genes for DNAJC5G using alignment to 4 protein entries:     DNJ5G_HUMAN (see all proteins):
    DNAJB6    DKFZp761N1221    DNAJB4    DNAJB5    DNAJC17    FLJ00095
    DNAJC5B    DNAJC5    DNAJB3    DNAJC24    ZCSL3

    DNAJC5G for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/172 SNPs in DNAJC5G are shown (see all 172)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1433538421,2
    --27496571(+) ATTCAC/TTAATT 1 -- us2k10--------
    rs133864471,2
    C,F,A,H--27496589(+) CATCAC/TGTCTG 1 -- us2k111Minor allele frequency- T:0.12NS EA NA WA 1310
    rs1475276841,2
    --27496713(+) GAGCTA/GGTTTG 1 -- us2k10--------
    rs1401081841,2
    --27496836(+) ACCTTC/TGAAGG 1 -- us2k10--------
    rs1810295621,2
    --27496846(+) GAGCTA/GGCGCA 1 -- us2k10--------
    rs1838750001,2
    --27496957(+) AGGCTA/GAGGCG 1 -- us2k10--------
    rs1892847811,2
    --27496961(+) TGAGGC/TGGGTA 1 -- us2k10--------
    rs1819528321,2
    --27496988(+) AGTTCA/GAAACC 1 -- us2k10--------
    rs1137268151,2
    C,F--27497151(+) TTGTGC/ACACTG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs728175361,2
    C--27497548(+) AAAAAA/GGAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DNAJC5G (27498289 - 27504367 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DNAJC5G:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv873754CNV Loss21882294
    nsv833614CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DNAJC5G for disorders           About MalaCards
    OMIM gene information: 613946    OMIM disorders: --


    DNAJC5G for disorders           About GeneDecksing


    Export disorders for DNAJC5G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DNAJC5G gene integrated from 9 sources:
    (articles sorted by number of sources associating them with DNAJC5G)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 285126 HGNC: 24844 AceView: DNAJC5G Ensembl:ENSG00000163793 euGenes: HUgn285126
    ECgene: DNAJC5G Kegg: 285126 H-InvDB: DNAJC5G

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DNAJC5G Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DNAJC5G gene:
    Search GeneIP for patents involving DNAJC5G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     inGenious Targeting Laboratory - Custom generated mouse model solutions for DNAJC5G
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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