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Aliases for DNAJC5B Gene

Aliases for DNAJC5B Gene

  • DnaJ (Hsp40) Homolog, Subfamily C, Member 5 Beta 2 3
  • Cysteine String Protein Beta 3 4
  • CSP-Beta 3 4
  • DnaJ Homolog Subfamily C Member 5B 3
  • DnaJ Homolog Subfamily C Member X 3
  • Beta Cysteine String Protein 3
  • Beta-CSP 3

External Ids for DNAJC5B Gene

Previous GeneCards Identifiers for DNAJC5B Gene

  • GC08P066984
  • GC08P067096
  • GC08P062423

Summaries for DNAJC5B Gene

GeneCards Summary for DNAJC5B Gene

DNAJC5B (DnaJ (Hsp40) Homolog, Subfamily C, Member 5 Beta) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum. An important paralog of this gene is DNAJB7.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC5B Gene

Genomics for DNAJC5B Gene

Regulatory Elements for DNAJC5B Gene

Genomic Location for DNAJC5B Gene

66,021,556 bp from pter
66,100,526 bp from pter
78,971 bases
Plus strand

Genomic View for DNAJC5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJC5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC5B Gene

Proteins for DNAJC5B Gene

  • Protein details for DNAJC5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily C member 5B
    Protein Accession:
    Secondary Accessions:
    • Q969Y8

    Protein attributes for DNAJC5B Gene

    199 amino acids
    Molecular mass:
    22496 Da
    Quaternary structure:
    • Interacts with the chaperone complex consisting of HSC70 and SGTA.

neXtProt entry for DNAJC5B Gene

Proteomics data for DNAJC5B Gene at MOPED

Post-translational modifications for DNAJC5B Gene

  • Palmitoylated. Palmitoylation is not required for membrane association.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJC5B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJC5B Gene

Domains for DNAJC5B Gene

Gene Families for DNAJC5B Gene

Protein Domains for DNAJC5B Gene


Suggested Antigen Peptide Sequences for DNAJC5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 J domain.
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJC5B: view

Function for DNAJC5B Gene

Gene Ontology (GO) - Molecular Function for DNAJC5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DNAJC5B: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJC5B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DNAJC5B Gene

Localization for DNAJC5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC5B Gene

Membrane; Lipid-anchor. Note=May be associated with the trans-Golgi network. {ECO:0000269 PubMed:17034881}.

Subcellular locations from

Jensen Localization Image for DNAJC5B Gene COMPARTMENTS Subcellular localization image for DNAJC5B gene
Compartment Confidence
cytosol 3
mitochondrion 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DNAJC5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DNAJC5B: view

Pathways for DNAJC5B Gene

genes like me logo Genes that share pathways with DNAJC5B: view

Pathways by source for DNAJC5B Gene

1 KEGG pathway for DNAJC5B Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DNAJC5B Gene


Transcripts for DNAJC5B Gene

Unigene Clusters for DNAJC5B Gene

DnaJ (Hsp40) homolog, subfamily C, member 5 beta:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJC5B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC5B Gene

No ASD Table

Relevant External Links for DNAJC5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJC5B Gene

mRNA expression in normal human tissues for DNAJC5B Gene

mRNA differential expression in normal tissues according to GTEx for DNAJC5B Gene

This gene is overexpressed in Testis (44.9).

SOURCE GeneReport for Unigene cluster for DNAJC5B Gene Hs.491885

mRNA Expression by UniProt/SwissProt for DNAJC5B Gene

Tissue specificity: Testis specific
genes like me logo Genes that share expressions with DNAJC5B: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Expression partners for DNAJC5B Gene

Orthologs for DNAJC5B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNAJC5B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DNAJC5B 35
  • 89.28 (n)
  • 88.44 (a)
  • 88 (a)
(Canis familiaris)
Mammalia DNAJC5B 35
  • 92.46 (n)
  • 91.46 (a)
  • 91 (a)
(Mus musculus)
Mammalia Dnajc5b 35
  • 89.61 (n)
  • 88.94 (a)
Dnajc5b 16
Dnajc5b 36
  • 89 (a)
(Pan troglodytes)
Mammalia DNAJC5B 35
  • 99.5 (n)
  • 99.5 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Dnajc5b 35
  • 89.28 (n)
  • 87.94 (a)
(Monodelphis domestica)
Mammalia DNAJC5B 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia DNAJC5B 36
  • 78 (a)
(Gallus gallus)
Aves DNAJC5B 35
  • 74.7 (n)
  • 75.38 (a)
  • 74 (a)
(Anolis carolinensis)
Reptilia DNAJC5B 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc5b 35
  • 72.65 (n)
  • 74.36 (a)
(Danio rerio)
Actinopterygii dnajc5b 35
  • 70.74 (n)
  • 71.81 (a)
wufb75d01 35
dnajc5b 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Csp 36
  • 40 (a)
(Caenorhabditis elegans)
Secernentea dnj-14 36
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SIS1 36
  • 16 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11018 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8441 36
  • 51 (a)
Species with no ortholog for DNAJC5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC5B Gene

Gene Tree for DNAJC5B (if available)
Gene Tree for DNAJC5B (if available)

Paralogs for DNAJC5B Gene

genes like me logo Genes that share paralogs with DNAJC5B: view

Variants for DNAJC5B Gene

Sequence variations from dbSNP and Humsavar for DNAJC5B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs952424 -- 66,020,891(+) cctca(G/T)cctcc upstream-variant-2KB
rs953177 -- 66,021,385(-) ATTTG(C/T)TCTGC upstream-variant-2KB
rs961212 -- 66,035,083(-) attca(A/G)caatg intron-variant
rs961213 -- 66,035,019(-) ATGTC(A/C/G)ATAGC intron-variant
rs2357657 -- 66,024,255(+) CTTTA(A/C)ACAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC5B Gene

Variant ID Type Subtype PubMed ID
esv2657842 CNV Deletion 23128226

Relevant External Links for DNAJC5B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC5B Gene

Disorders for DNAJC5B Gene

Relevant External Links for DNAJC5B

Genetic Association Database (GAD)

No disorders were found for DNAJC5B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DNAJC5B Gene

Publications for DNAJC5B Gene

  1. Cysteine-string protein isoform beta (Cspbeta) is targeted to the trans-Golgi network as a non-palmitoylated CSP in clonal beta-cells. (PMID: 17034881) Boal F. … Lang J. (Biochim. Biophys. Acta 2007) 3 4 23
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PMID: 22174851) Lingappa J.R. … Goldstein D. (PLoS ONE 2011) 3

Products for DNAJC5B Gene

Sources for DNAJC5B Gene

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