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DNAJC5B Gene

protein-coding   GIFtS: 47
GCID: GC08P066984

DnaJ (Hsp40) Homolog, Subfamily C, Member 5 Beta

  Search for DNAJC5B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DnaJ (Hsp40) Homolog, Subfamily C, Member 5 Beta1 2     beta-CSP2
Cysteine String Protein Beta2 3     DnaJ Homolog Subfamily C Member 5B2
CSP-beta2 3     DnaJ Homolog Subfamily C Member X2
Beta Cysteine String Protein2     

External Ids:    HGNC: 241381   Entrez Gene: 854792   Ensembl: ENSG000001475707   OMIM: 6139455   UniProtKB: Q9UF473   

Export aliases for DNAJC5B gene to outside databases

Previous GC identifers: GC08P067096 GC08P062423


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DNAJC5B Gene:
DNAJC5B (DnaJ (Hsp40) homolog, subfamily C, member 5 beta) is a protein-coding gene. An important paralog of this gene is DNAJB4.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAJC5B gene promoter:
         TBP   AML1a   RORalpha2   POU2F1   FOXJ2 (long isoform)   POU2F1a   FOXO1a   FOXJ2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJC5B promoter sequence
   Search Chromatin IP Primers for DNAJC5B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAJC5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13.1   Ensembl cytogenetic band:  8q13.1   HGNC cytogenetic band: 8q13.1

DNAJC5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJC5B gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P066984:  view genomic region     (about GC identifiers)

Start:
66,933,791 bp from pter      End:
67,012,755 bp from pter
Size:
78,965 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DNJ5B_HUMAN, Q9UF47 (See protein sequence)
Recommended Name: DnaJ homolog subfamily C member 5B  
Size: 199 amino acids; 22496 Da
Subunit: Interacts with the chaperone complex consisting of HSC70 and SGTA
Secondary accessions: Q969Y8

Explore the universe of human proteins at neXtProt for DNAJC5B: NX_Q9UF47

Explore proteomics data for DNAJC5B at MOPED

Post-translational modifications: 

  • Palmitoylated. Palmitoylation is not required for membrane association1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DNAJC5B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_149096.2  
    ENSEMBL proteins: 
     ENSP00000276570   ENSP00000430196  

    DNAJC5B Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DNAJC5B

     
    Search eBioscience for Proteins for DNAJC5B 

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    LSBio Antibodies in human, mouse, rat for DNAJC5B

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    Cloud-Clone Corp. CLIAs for DNAJC5B
    Search eBioscience for ELISAs for DNAJC5B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    2 InterPro protein domains:
     IPR001623 DnaJ_domain
     IPR018253 DnaJ_domain_CS

    Graphical View of Domain Structure for InterPro Entry Q9UF47

    ProtoNet protein and cluster: Q9UF47

    UniProtKB/Swiss-Prot: DNJ5B_HUMAN, Q9UF47
    Similarity: Contains 1 J domain


    Find genes that share domains with DNAJC5B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 MGI phenotypic allele for Dnajc5b (no phenotypes)

    Find genes that share phenotypes with DNAJC5B           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNAJC5B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DNAJC5B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DNAJC5B
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    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate DNAJC5B:
    hsa-miR-3142 hsa-miR-539 hsa-miR-3647-3p
    SwitchGear 3'UTR luciferase reporter plasmidDNAJC5B 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat DNAJC5B

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DNJ5B_HUMAN, Q9UF47: Membrane; Lipid-anchor. Note=May be associated with the trans-Golgi network
    (PubMed:17034881)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion2
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane IEA--

    Find genes that share ontologies with DNAJC5B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DNAJC5B About    
    See pathways by source

    SuperPathContained pathways About
    1Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum


    Find genes that share SuperPaths with DNAJC5B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for DNAJC5B):
        Protein processing in endoplasmic reticulum

        Pathway & Disease-focused RT2 Profiler PCR Array including DNAJC5B: 
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DNAJC5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNAJC5B (ENSP000002765704) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STUB1ENSP000002195484STRING: ENSP00000219548
    UBE2D2ENSP000003817174STRING: ENSP00000381717
    UBE2D3ENSP000003497224STRING: ENSP00000349722
    UBE2D4ENSP000002224024STRING: ENSP00000222402
    UBE2E2ENSP000003799314STRING: ENSP00000379931
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNAJC5B (DNJ5B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DNAJC5B gene: 
    NM_033105.4  

    Unigene Cluster for DNAJC5B:

    DnaJ (Hsp40) homolog, subfamily C, member 5 beta
    Hs.491885  [show with all ESTs]
    Unigene Representative Sequence: AL133660
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524076 ENST00000276570(uc003xvs.1) ENST00000519330(uc003xvt.1)
    ENST00000522619
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate DNAJC5B:
    hsa-miR-3142 hsa-miR-539 hsa-miR-3647-3p
    SwitchGear 3'UTR luciferase reporter plasmidDNAJC5B 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat DNAJC5B
      QuantiFast Probe-based Assays in human, mouse, rat DNAJC5B

    Additional mRNA sequence: 

    AF368276.1 AL133660.1 BC016742.2 

    4 DOTS entries:

    DT.431479  DT.100740757  DT.91673285  DT.99997700 

    23 AceView cDNA sequences:

    AL133660 BU627018 BX336644 CR607613 BM554447 BG717416 BI829610 BG718091 
    BG701336 BF115620 AW182475 BP369015 AA812978 BC016742 AW235250 NM_033105 
    AI223433 AF368276 AW975558 AI126166 AV712976 BG192691 BX369934 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNAJC5B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DNAJC5B Expression
    About this image

    DNAJC5B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAJC5B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.491885

    UniProtKB/Swiss-Prot: DNJ5B_HUMAN, Q9UF47
    Tissue specificity: Testis specific

        Pathway & Disease-focused RT2 Profiler PCR Array including DNAJC5B: 
              Heat Shock Proteins & Chaperones in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DNAJC5B gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnajc5b1 , 5 DnaJ (Hsp40) homolog, subfamily C, member 5 beta1, 5 89.61(n)1
    88.94(a)1
      3 (5.55 cM)5
    663261  NM_025489.31  NP_079765.31 
     195085955 
    chicken
    (Gallus gallus)
    Aves DNAJC5B1 DnaJ (Hsp40) homolog, subfamily C, member 5 beta 74.7(n)
    75.38(a)
      428358  XM_425918.4  XP_425918.3 
    lizard
    (Anolis carolinensis)
    Reptilia DNAJC5B6
    DnaJ (Hsp40) homolog, subfamily C, member 5 beta
    75(a)
    1 ↔ 1
    4(30654917-30668896)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dnajc5b1 DnaJ (Hsp40) homolog, subfamily C, member 5 beta 72.65(n)
    74.36(a)
      100379708  XM_002940560.1  XP_002940606.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb75d012 wufb75d01 74.84(n)   322863  BC049534.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Csp6
    Cysteine string protein
    40(a)
    1 → many
    3L(22260361-22266845)
    worm
    (Caenorhabditis elegans)
    Secernentea dnj-146
    Protein DNJ-14, isoform a (dnj-14) mRNA, complete ...
    35(a)
    1 → many
    X(4709826-4711744) WBGene00001032
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SIS16
    Type II HSP40 co-chaperone that interacts with the...
    16(a)
    1 → many
    XIV(618507-619565) YNL007C


    ENSEMBL Gene Tree for DNAJC5B (if available)
    TreeFam Gene Tree for DNAJC5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNAJC5B gene
    DNAJB42  DNAJB52  DNAJB132  DNAJB22  DNAJB92  DNAJB62  DNAJB12  DNAJB72  
    DNAJC52  DNAJC5G2  DNAJB82  
    Selected SIMAP similar genes for DNAJC5B using alignment to 2 protein entries:     DNJ5B_HUMAN (see all proteins) (see all similar genes):
    DNAJC5    FLJ00095    DNAJA2    DNAJA4    DKFZp761N1221    DNAJB6
    DNAJB5    DNAJC17    DNAJC18    DNAJB3    DNAJB4    DNAJA3
    DNAJB2    DNAJC5G    DNAJC27    DNAJC1    DNAJC4    DNAJC24

    Find genes that share paralogs with DNAJC5B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNAJC5B (see all 1587)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs744300761,2
    C,F--66931909(+) TTAGTG/ACAGAT 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1816645871,2
    --66932063(+) ACCTCC/TTGTAG 1 -- us2k10--------
    rs101048771,2
    C,F,A,H--66932244(+) ACCTAT/CGGGAA 1 -- us2k111Minor allele frequency- C:0.41NS NA WA CSA EA 588
    rs1409914531,2
    --66932507(+) CTCACC/TAAGTT 1 -- us2k10--------
    rs1843928401,2
    --66932551(+) AGCTTA/GTAAAT 1 -- us2k10--------
    rs1152797641,2
    F--66932624(+) ATTCTT/AAAAGC 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1887046101,2
    --66932680(+) ACTTTG/TTAGTA 1 -- us2k10--------
    rs39053311,2
    C,F,H--66932804(+) AGAACC/ATGGTA 1 -- us2k19Minor allele frequency- A:0.01NS EA NA 852
    rs1810898271,2
    --66932812(+) GTATAA/GCGCTG 1 -- us2k10--------
    rs105260181,2
    C--66932830(+) TACTC-/TGTGTGTGTGTGTG
    TGTGTGTGTGTGTGTG
    TGTGT
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DNAJC5B (66933791 - 67012755 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DNAJC5B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2657842CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAJC5B
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAJC5B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613945    OMIM disorders: --


    Find genes that share disorders with DNAJC5B           About GenesLikeMe

    Genetic Association Database (GAD): DNAJC5B

    Export disorders for DNAJC5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNAJC5B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with DNAJC5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cysteine-string protein isoform beta (Cspbeta) is targeted to the trans-Golgi network as a non-palmitoylated CSP in clonal beta-cells. (PubMed id 17034881)1, 2, 9 Boal F.... Lang J. (Biochim. Biophys. Acta 2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy. (PubMed id 22666496)1 Shiffman D....Jukema J.W. (PLoS ONE 2012)
    5. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PubMed id 22174851)1 Lingappa J.R....Goldstein D. (PLoS ONE 2011)
    6. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (BMC Med. Genet. 2007)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    9. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85479 HGNC: 24138 AceView: DNAJC5B Ensembl:ENSG00000147570 euGenes: HUgn85479
    ECgene: DNAJC5B Kegg: 85479 H-InvDB: DNAJC5B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DNAJC5B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNAJC5B gene:
    Search GeneIP for patents involving DNAJC5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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