Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DNAJC5B Gene

Aliases for DNAJC5B Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C5 Beta 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 5 Beta 2 3
  • Cysteine String Protein Beta 3 4
  • CSP-Beta 3 4
  • DnaJ Homolog Subfamily C Member X 3
  • Testicular Tissue Protein Li 55 3
  • Beta Cysteine String Protein 3
  • Beta-CSP 3

External Ids for DNAJC5B Gene

Previous GeneCards Identifiers for DNAJC5B Gene

  • GC08P066984
  • GC08P067096
  • GC08P062423

Summaries for DNAJC5B Gene

GeneCards Summary for DNAJC5B Gene

DNAJC5B (DnaJ Heat Shock Protein Family (Hsp40) Member C5 Beta) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum. An important paralog of this gene is DNAJB7.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC5B Gene

Genomics for DNAJC5B Gene

Regulatory Elements for DNAJC5B Gene

Enhancers for DNAJC5B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DNAJC5B on UCSC Golden Path with GeneCards custom track

Genomic Location for DNAJC5B Gene

66,015,042 bp from pter
66,100,526 bp from pter
85,485 bases
Plus strand

Genomic View for DNAJC5B Gene

Genes around DNAJC5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC5B Gene

Proteins for DNAJC5B Gene

  • Protein details for DNAJC5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily C member 5B
    Protein Accession:
    Secondary Accessions:
    • Q969Y8

    Protein attributes for DNAJC5B Gene

    199 amino acids
    Molecular mass:
    22496 Da
    Quaternary structure:
    • Interacts with the chaperone complex consisting of HSC70 and SGTA.

neXtProt entry for DNAJC5B Gene

Proteomics data for DNAJC5B Gene at MOPED

Post-translational modifications for DNAJC5B Gene

  • Palmitoylated. Palmitoylation is not required for membrane association.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJC5B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJC5B Gene

Domains & Families for DNAJC5B Gene

Gene Families for DNAJC5B Gene

Protein Domains for DNAJC5B Gene


Suggested Antigen Peptide Sequences for DNAJC5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 J domain.
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJC5B: view

Function for DNAJC5B Gene

genes like me logo Genes that share phenotypes with DNAJC5B: view

Animal Models for DNAJC5B Gene

MGI Knock Outs for DNAJC5B:

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DNAJC5B Gene

Localization for DNAJC5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC5B Gene

Membrane; Lipid-anchor. Note=May be associated with the trans-Golgi network. {ECO:0000269 PubMed:17034881}.

Subcellular locations from

Jensen Localization Image for DNAJC5B Gene COMPARTMENTS Subcellular localization image for DNAJC5B gene
Compartment Confidence
cytosol 3
mitochondrion 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for DNAJC5B Gene

Pathways & Interactions for DNAJC5B Gene

genes like me logo Genes that share pathways with DNAJC5B: view

Pathways by source for DNAJC5B Gene

1 KEGG pathway for DNAJC5B Gene

Gene Ontology (GO) - Biological Process for DNAJC5B Gene


No data available for SIGNOR curated interactions for DNAJC5B Gene

Drugs & Compounds for DNAJC5B Gene

No Compound Related Data Available

Transcripts for DNAJC5B Gene

Unigene Clusters for DNAJC5B Gene

DnaJ (Hsp40) homolog, subfamily C, member 5 beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC5B Gene

No ASD Table

Relevant External Links for DNAJC5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJC5B Gene

mRNA expression in normal human tissues for DNAJC5B Gene

mRNA differential expression in normal tissues according to GTEx for DNAJC5B Gene

This gene is overexpressed in Testis (x44.9).

SOURCE GeneReport for Unigene cluster for DNAJC5B Gene Hs.491885

mRNA Expression by UniProt/SwissProt for DNAJC5B Gene

Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with DNAJC5B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DNAJC5B Gene

Orthologs for DNAJC5B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNAJC5B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DNAJC5B 35
  • 89.28 (n)
  • 88.44 (a)
  • 88 (a)
(Canis familiaris)
Mammalia DNAJC5B 35
  • 92.46 (n)
  • 91.46 (a)
  • 91 (a)
(Mus musculus)
Mammalia Dnajc5b 35
  • 89.61 (n)
  • 88.94 (a)
Dnajc5b 16
Dnajc5b 36
  • 89 (a)
(Pan troglodytes)
Mammalia DNAJC5B 35
  • 99.5 (n)
  • 99.5 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Dnajc5b 35
  • 89.28 (n)
  • 87.94 (a)
(Monodelphis domestica)
Mammalia DNAJC5B 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia DNAJC5B 36
  • 78 (a)
(Gallus gallus)
Aves DNAJC5B 35
  • 74.7 (n)
  • 75.38 (a)
  • 74 (a)
(Anolis carolinensis)
Reptilia DNAJC5B 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc5b 35
  • 72.65 (n)
  • 74.36 (a)
(Danio rerio)
Actinopterygii dnajc5b 35
  • 70.74 (n)
  • 71.81 (a)
wufb75d01 35
dnajc5b 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Csp 36
  • 40 (a)
(Caenorhabditis elegans)
Secernentea dnj-14 36
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SIS1 36
  • 16 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11018 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8441 36
  • 51 (a)
Species with no ortholog for DNAJC5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC5B Gene

Gene Tree for DNAJC5B (if available)
Gene Tree for DNAJC5B (if available)

Paralogs for DNAJC5B Gene

genes like me logo Genes that share paralogs with DNAJC5B: view

Variants for DNAJC5B Gene

Sequence variations from dbSNP and Humsavar for DNAJC5B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2357658 -- 66,027,895(+) gcacc(C/T)gggac intron-variant
rs2357659 -- 66,028,770(+) TCTAA(A/G)ATCAC intron-variant
rs2357660 -- 66,028,928(+) AGCTT(C/G)ACTGG intron-variant
rs2357661 -- 66,029,021(+) TCCAG(C/T)TTGCC intron-variant
rs2357662 -- 66,032,471(+) ACAAC(A/T)TTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC5B Gene

Variant ID Type Subtype PubMed ID
esv2657842 CNV Deletion 23128226

Variation tolerance for DNAJC5B Gene

Residual Variation Intolerance Score: 80% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DNAJC5B Gene

Disorders for DNAJC5B Gene

Relevant External Links for DNAJC5B

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DNAJC5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC5B Gene

Publications for DNAJC5B Gene

  1. Cysteine-string protein isoform beta (Cspbeta) is targeted to the trans-Golgi network as a non-palmitoylated CSP in clonal beta-cells. (PMID: 17034881) Boal F. … Lang J. (Biochim. Biophys. Acta 2007) 3 4 23 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy. (PMID: 22666496) Shiffman D. … Jukema J.W. (PLoS ONE 2012) 3
  5. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PMID: 22174851) Lingappa J.R. … Goldstein D. (PLoS ONE 2011) 3

Products for DNAJC5B Gene

Sources for DNAJC5B Gene