DNAJC5B Gene
protein-coding GIFtS: 45
GCID: GC08P066984
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DnaJ (Hsp40) homolog, subfamily C, member 5 beta
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Aliases
for DNAJC5B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DnaJ (Hsp40) Homolog, Subfamily C, Member 5 Beta1 2 | | Beta Cysteine String Protein2 | | CSP-Beta1 | | Beta-CSP1 | | Cysteine String Protein Beta2 3 | | DnaJ Homolog Subfamily C Member 5B2 | | MGC262261 | | DnaJ Homolog Subfamily C Member X2 |
Export aliases for DNAJC5B gene to outside databasesPrevious GC identifers: GC08P067096 GC08P062423 |
Summaries
for DNAJC5B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for DNAJC5B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DNAJC5B gene promoter:
TBP AML1a RORalpha2 POU2F1 FOXJ2 (long isoform) POU2F1a FOXO1a FOXJ2 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DNAJC5B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJC5B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q13.1 Ensembl cytogenetic band: 8q13.1 HGNC cytogenetic band: 8q13.1DNAJC5B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P066984: view genomic region
(about GC identifiers)
Start:
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66,933,791 bp from pter |
End:
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67,012,755 bp from pter |
Size:
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78,965 bases |
Orientation:
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plus strand |
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Proteins
for DNAJC5B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DNJ5B_HUMAN, Q9UF47 (See
protein sequence)Recommended Name: DnaJ homolog subfamily C member 5B Size: 199 amino acids; 22496 Da
Subunit: Interacts with the chaperone complex consisting of HSC70 and SGTA
Subcellular location: Membrane; Lipid-anchor. Note=May be associated with the trans-Golgi network (PubMed:17034881)
Secondary accessions: Q969Y8Explore the universe of human proteins at neXtProt for DNAJC5B: NX_Q9UF47
Post-translational modifications:
Palmitoylated. Palmitoylation is not required for membrane association1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UF47
DNAJC5B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_149096.2
ENSEMBL proteins: ENSP00000276570 ENSP00000430196
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- |
DNAJC5B for ontologies About GeneDecksing
DNAJC5B Antibody Products:
Assay Products for DNAJC5B: |
Protein
Domains /
Families
for DNAJC5B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DNAJC5B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UF47ProtoNet protein and cluster: Q9UF47 UniProtKB/Swiss-Prot: DNJ5B_HUMAN, Q9UF47Similarity: Contains 1 J domain |
Function
for DNAJC5B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC5B (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC5B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for DNAJC5B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC5B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC5B |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0031072 | heat shock protein binding |
IEA | -- | | GO:0051082 | unfolded protein binding |
IEA | -- |
DNAJC5B for ontologies About GeneDecksing
|
Pathways & Interactions
for DNAJC5B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Protein processing in endoplasmic reticulum | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for DNAJC5B):
DNAJC5B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNAJC5B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/12 Interacting proteins for DNAJC5B (ENSP000002765704) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006457 | protein folding |
IEA | -- |
DNAJC5B for ontologies About GeneDecksing
|
Drugs & Compounds
for DNAJC5B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DNAJC5B
Search CenterWatch for drugs/clinical trials and news about DNAJC5B / DNJ5B
|
Transcripts
for DNAJC5B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DNAJC5B gene: NM_033105.4 Unigene Cluster for DNAJC5B: DnaJ (Hsp40) homolog, subfamily C, member 5 beta Hs.491885 [show with all ESTs]Unigene Representative Sequence: AL1336604 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000524076 ENST00000276570(uc003xvs.1) ENST00000519330(uc003xvt.1)
ENST00000522619
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC5B (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC5B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DNAJC5B (NM_033105) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DNAJC5B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC5B |
Additional cDNA sequence: AF368276.1 AL133660.1 BC016742.2 4 DOTS entries: DT.431479 DT.100740757 DT.91673285 DT.99997700 23 AceView cDNA sequences: BX336644 AL133660 BU627018 BM554447 CR607613 BG717416 BC016742 BI829610 BP369015 BG701336 AA812978 NM_033105 AW182475 BF115620 AW235250 BG718091 AI223433 AF368276 AW975558 AI126166 AV712976 BG192691 BX369934
GeneLoc Exon Structure
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Expression
for DNAJC5B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DNAJC5B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See DNAJC5B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DNAJC5B
SOURCE GeneReport for Unigene cluster: Hs.491885
UniProtKB/Swiss-Prot: DNJ5B_HUMAN, Q9UF47Tissue specificity: Testis specific
SABiosciences Expression via Pathway-Focused PCR Array including DNAJC5B:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNAJC5B
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC5B |
Orthologs
for DNAJC5B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DNAJC5B gene from 5/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
DNAJC5B1 |
DnaJ (Hsp40) homolog, subfamily C, member 5 beta |
75(n)
76.56(a) |
|
428358 XM_425918.3 XP_425918.3 |
lizard
(Anolis carolinensis) |
Reptilia |
DNAJC5B6 |
-- |
76(a) |
1 ↔ 1 |
4(30654917-30668896) |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb75d012 |
wufb75d01 |
74.84(n) |
|
322863 BC049534.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Csp6DnaJ-H6 |
DnaJ homolog |
39(a)10(a) |
1 ↔ manypossible ortholog |
3L(22260361-22266845) 2L(13163209-13166072) |
worm
(Caenorhabditis elegans) |
Secernentea |
dnj-146 |
DNaJ domain (prokaryotic heat shock protein) famil... |
18(a) |
possible ortholog |
X(4709838-4711715) |
ENSEMBL Gene Tree for DNAJC5B (if available)
TreeFam Gene Tree for DNAJC5B (if available) |
Paralogs
for DNAJC5B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DNAJC5B gene
- DNAJC52 DNAJC5G2
18/19 SIMAP similar genes for DNAJC5B using alignment to 2 protein entries: DNJ5B_HUMAN (see all proteins)
(see all similar genes):DNAJC5 FLJ00095 DNAJA2 DNAJA4 DKFZp761N1221 DNAJB6
DNAJB5 DNAJC17 DNAJC18 DNAJB3 DNAJB4 DNAJA3
DNAJB2 DNAJC5G DNAJC27 DNAJC1 DNAJC4 DNAJC24
DNAJC5B for paralogs About GeneDecksing
|
Genomic Variants
for DNAJC5B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DNAJC5B (66933791 - 67012755 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DNAJC5B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNAJC5B |
|
Disorders
/ Diseases
for DNAJC5B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DNAJC5B for disorders About GeneDecksing
OMIM gene information: 613945
OMIM disorders: --
1  disease for DNAJC5B: About MalaCardsblindness
Export disorders for DNAJC5B gene to outside databases
|
Publications
for DNAJC5B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DNAJC5B gene integrated from 9 sources:
(articles sorted by number of sources associating them with DNAJC5B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cysteine-string protein isoform beta (Cspbeta) is targeted to the trans-Golgi network as a non-palmitoylated CSP in clonal beta-cells. (PubMed id 17034881)1, 2, 9 Boal F....Lang J. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Genome-wide study of gene variants associated with dif ferential cardiovascular event reduction by pravastatin therapy. (PubMed id 22666496)1 Shiffman D....Jukema J.W. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PubMed id 22174851)1 Lingappa J.R....Goldstein D. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for DNAJC5B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DNAJC5B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DNAJC5B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DNAJC5B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DNAJC5B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DNAJC5B gene:
Search GeneIP for patents involving DNAJC5B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DNAJC5B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DNAJC5B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNAJC5B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJC5B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNAJC5B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAJC5B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAJC5B |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC5B |
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