Aliases for DNAJC5 Gene
External Ids for DNAJC5 Gene
Previous HGNC Symbols for DNAJC5 Gene
Previous GeneCards Identifiers for DNAJC5 Gene
This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8. [provided by RefSeq, Nov 2010]
GeneCards Summary for DNAJC5 Gene
DNAJC5 (DnaJ Heat Shock Protein Family (Hsp40) Member C5) is a Protein Coding gene. Diseases associated with DNAJC5 include Ceroid Lipofuscinosis, Neuronal, 4, Parry Type and Cln4 Disease. Among its related pathways are Regulation of degradation of deltaF508 CFTR in CF and Transmission across Chemical Synapses. GO annotations related to this gene include glycoprotein binding and ATP-dependent protein binding. An important paralog of this gene is DNAJB7.
UniProtKB/Swiss-Prot for DNAJC5 Gene
May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity).