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Aliases for DNAJC4 Gene

Aliases for DNAJC4 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C4 2 3 5
  • Multiple Endocrine Neoplasia Type 1 Candidate Protein Number 18 3 4
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 4 2 3
  • DnaJ-Like Protein HSPF2 3 4
  • HSPF2 3 4
  • MCG18 3 4
  • DnaJ Homolog Subfamily C Member 4 3
  • Heat Shock 40kD Protein 2 3
  • DANJC4 3

External Ids for DNAJC4 Gene

Previous HGNC Symbols for DNAJC4 Gene

  • HSPF2

Previous GeneCards Identifiers for DNAJC4 Gene

  • GC11P066510
  • GC11P065679
  • GC11P064249
  • GC11P063773
  • GC11P063754
  • GC11P063997
  • GC11P060325

Summaries for DNAJC4 Gene

GeneCards Summary for DNAJC4 Gene

DNAJC4 (DnaJ Heat Shock Protein Family (Hsp40) Member C4) is a Protein Coding gene. GO annotations related to this gene include unfolded protein binding.

Additional gene information for DNAJC4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC4 Gene

Genomics for DNAJC4 Gene

Regulatory Elements for DNAJC4 Gene

Enhancers for DNAJC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H064267 1.4 ENCODE dbSUPER 21.3 +40.5 40466 7.2 DMAP1 YY1 SLC30A9 ZNF143 SP3 MCM3 NFYC MEF2D SSRP1 ZNF585B ZFPL1 SF1 POLA2 PLCB3 ENSG00000257086 TRMT112 DNAJC4 FAU LOC102723878 TRPT1
GH11H064183 1.4 FANTOM5 ENCODE 9.9 -44.6 -44561 4.4 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SF1 TRPT1 IMMP1LP1 ENSG00000257086 ZFPL1 FERMT3 C11orf95 ZNHIT2 PLCB3 TRMT112
GH11H064316 1.4 ENCODE dbSUPER 9.8 +87.9 87901 4.1 HDGF FOXA2 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SF1 POLA2 ZFPL1 ENSG00000257086 TRMT112 PLCB3 ZNHIT2 IMMP1LP1 DNAJC4 ATG2A
GH11H065129 1.4 ENCODE dbSUPER 9.7 +903.0 903040 7.2 HDGF FOXA2 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SPDYC LOC728975 SSSCA1 PGAM1P8 CAPN1 ZNHIT2 SF1 POLA2 SCYL1 EIF1AD
GH11H064282 1.3 ENCODE dbSUPER 9.9 +54.6 54584 3.8 HDGF PKNOX1 ARID4B SIN3A YY1 SLC30A9 ZNF766 ZNF143 ZNF207 FOS SF1 POLA2 LOC102723878 TRMT112 ZFPL1 ZNHIT2 PLCB3 ENSG00000257086 FAU DNAJC4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DNAJC4 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040633 466 1401 HDGF PKNOX1 ATF1 ZFP64 ARID4B SIN3A DMAP1 YY1 GLIS2 ZNF143

Genomic Locations for DNAJC4 Gene

Genomic Locations for DNAJC4 Gene
chr11:64,230,234-64,234,286
(GRCh38/hg38)
Size:
4,053 bases
Orientation:
Plus strand
chr11:63,997,750-64,001,758
(GRCh37/hg19)

Genomic View for DNAJC4 Gene

Genes around DNAJC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC4 Gene

Proteins for DNAJC4 Gene

  • Protein details for DNAJC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NNZ3-DNJC4_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 4
    Protein Accession:
    Q9NNZ3
    Secondary Accessions:
    • O14716

    Protein attributes for DNAJC4 Gene

    Size:
    241 amino acids
    Molecular mass:
    27593 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB82426.1; Type=Miscellaneous discrepancy; Note=Several sequence rearrangements.; Evidence={ECO:0000305};

neXtProt entry for DNAJC4 Gene

Post-translational modifications for DNAJC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJC4 Gene

No data available for DME Specific Peptides for DNAJC4 Gene

Domains & Families for DNAJC4 Gene

Gene Families for DNAJC4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for DNAJC4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DNAJC4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNAJC4: view

No data available for UniProtKB/Swiss-Prot for DNAJC4 Gene

Function for DNAJC4 Gene

Phenotypes From GWAS Catalog for DNAJC4 Gene

Gene Ontology (GO) - Molecular Function for DNAJC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17500595
GO:0051082 unfolded protein binding NAS 9473517
genes like me logo Genes that share ontologies with DNAJC4: view
genes like me logo Genes that share phenotypes with DNAJC4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DNAJC4 Gene

Localization for DNAJC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC4 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJC4 gene
Compartment Confidence
mitochondrion 3
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DNAJC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0016020 membrane NAS,IEA 9473517
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DNAJC4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DNAJC4 Gene

Pathways & Interactions for DNAJC4 Gene

SuperPathways for DNAJC4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding NAS 9473517
GO:0006986 response to unfolded protein TAS 9473517
genes like me logo Genes that share ontologies with DNAJC4: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJC4 Gene

Drugs & Compounds for DNAJC4 Gene

No Compound Related Data Available

Transcripts for DNAJC4 Gene

Unigene Clusters for DNAJC4 Gene

DnaJ (Hsp40) homolog, subfamily C, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e · 11f
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - -
SP8: - -
SP9: - - - - - - - - - - -
SP10:
SP11: -
SP12:
SP13: - - - - - - - - - - - - - -
SP14:

Relevant External Links for DNAJC4 Gene

GeneLoc Exon Structure for
DNAJC4
ECgene alternative splicing isoforms for
DNAJC4

Expression for DNAJC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJC4 Gene

mRNA differential expression in normal tissues according to GTEx for DNAJC4 Gene

This gene is overexpressed in Testis (x4.8).

NURSA nuclear receptor signaling pathways regulating expression of DNAJC4 Gene:

DNAJC4

SOURCE GeneReport for Unigene cluster for DNAJC4 Gene:

Hs.172847

Evidence on tissue expression from TISSUES for DNAJC4 Gene

  • Nervous system(4.3)
  • Lung(2.9)
genes like me logo Genes that share expression patterns with DNAJC4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJC4 Gene

Orthologs for DNAJC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAJC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC4 33 34
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia DNAJC4 33 34
  • 84.94 (n)
cow
(Bos Taurus)
Mammalia DNAJC4 33 34
  • 84.6 (n)
rat
(Rattus norvegicus)
Mammalia Dnajc4 33
  • 78.48 (n)
mouse
(Mus musculus)
Mammalia Dnajc4 33 16 34
  • 78.32 (n)
oppossum
(Monodelphis domestica)
Mammalia DNAJC4 34
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJC4 34
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc4 33
  • 55.02 (n)
zebrafish
(Danio rerio)
Actinopterygii dnajc4 33 34
  • 55.86 (n)
worm
(Caenorhabditis elegans)
Secernentea dnj-4 34
  • 21 (a)
OneToOne
Species where no ortholog for DNAJC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC4 Gene

ENSEMBL:
Gene Tree for DNAJC4 (if available)
TreeFam:
Gene Tree for DNAJC4 (if available)

Paralogs for DNAJC4 Gene

(7) SIMAP similar genes for DNAJC4 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with DNAJC4: view

No data available for Paralogs for DNAJC4 Gene

Variants for DNAJC4 Gene

Sequence variations from dbSNP and Humsavar for DNAJC4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000136739 -- 64,228,904(+) GAGGC(A/G)GAGGT intron-variant, upstream-variant-2KB
rs1000299009 -- 64,228,632(+) GCACT(C/T)CAGCC intron-variant, upstream-variant-2KB
rs1000475163 -- 64,233,150(+) CAAAT(A/G)CAGCA intron-variant, upstream-variant-2KB
rs1000548533 -- 64,232,920(+) GAATT(C/T)CAGTG intron-variant, upstream-variant-2KB
rs1000579773 -- 64,232,714(+) GGACA(-/C)CCCCC upstream-variant-2KB, reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC4 Gene

Variant ID Type Subtype PubMed ID
nsv951010 CNV deletion 24416366
nsv832186 CNV loss 17160897
nsv555187 CNV loss 21841781
nsv555184 CNV loss 21841781
nsv469961 CNV loss 18288195
nsv1159904 CNV deletion 26073780
esv992196 CNV deletion 20482838
esv33033 CNV loss 17666407
esv24861 CNV gain 19812545
dgv1964n54 CNV loss 21841781
dgv1963n54 CNV loss 21841781

Variation tolerance for DNAJC4 Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC4 Gene

Disorders for DNAJC4 Gene

Relevant External Links for DNAJC4

Genetic Association Database (GAD)
DNAJC4
Human Genome Epidemiology (HuGE) Navigator
DNAJC4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJC4

No disorders were found for DNAJC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC4 Gene

Publications for DNAJC4 Gene

  1. Characterisation of a new human and murine member of the DnaJ family of proteins. (PMID: 9473517) Silins G … Hayward N (Biochemical and biophysical research communications 1998) 2 3 4 22 60
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K … Hata M (Cell stress & chaperones 2000) 2 3 60

Products for DNAJC4 Gene

Sources for DNAJC4 Gene

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