Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DNAJC4 Gene

Aliases for DNAJC4 Gene

  • DnaJ (Hsp40) Homolog, Subfamily C, Member 4 2 3
  • Multiple Endocrine Neoplasia Type 1 Candidate Protein Number 18 3 4
  • DnaJ-Like Protein HSPF2 3 4
  • HSPF2 3 4
  • MCG18 3 4
  • Heat Shock 40kD Protein 2 3
  • DANJC4 3

External Ids for DNAJC4 Gene

Previous HGNC Symbols for DNAJC4 Gene

  • HSPF2

Previous GeneCards Identifiers for DNAJC4 Gene

  • GC11P066510
  • GC11P065679
  • GC11P064249
  • GC11P063773
  • GC11P063754
  • GC11P063997
  • GC11P060325

Summaries for DNAJC4 Gene

GeneCards Summary for DNAJC4 Gene

DNAJC4 (DnaJ (Hsp40) Homolog, Subfamily C, Member 4) is a Protein Coding gene. GO annotations related to this gene include unfolded protein binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC4 Gene

Genomics for DNAJC4 Gene

Regulatory Elements for DNAJC4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DNAJC4 Gene

64,230,234 bp from pter
64,234,286 bp from pter
4,053 bases
Plus strand

Genomic View for DNAJC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC4 Gene

Proteins for DNAJC4 Gene

  • Protein details for DNAJC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily C member 4
    Protein Accession:
    Secondary Accessions:
    • O14716

    Protein attributes for DNAJC4 Gene

    241 amino acids
    Molecular mass:
    27593 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB82426.1; Type=Miscellaneous discrepancy; Note=Several sequence rearrangements.; Evidence={ECO:0000305};

neXtProt entry for DNAJC4 Gene

Proteomics data for DNAJC4 Gene at MOPED

Post-translational modifications for DNAJC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJC4 Gene

No data available for DME Specific Peptides for DNAJC4 Gene

Domains & Families for DNAJC4 Gene

Gene Families for DNAJC4 Gene

Protein Domains for DNAJC4 Gene


Suggested Antigen Peptide Sequences for DNAJC4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 J domain.
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJC4: view

Function for DNAJC4 Gene

Gene Ontology (GO) - Molecular Function for DNAJC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17500595
GO:0051082 unfolded protein binding NAS 9473517
genes like me logo Genes that share ontologies with DNAJC4: view

Phenotypes for DNAJC4 Gene

genes like me logo Genes that share phenotypes with DNAJC4: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJC4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DNAJC4 Gene

Localization for DNAJC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC4 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for DNAJC4 Gene COMPARTMENTS Subcellular localization image for DNAJC4 gene
Compartment Confidence
mitochondrion 2

Gene Ontology (GO) - Cellular Components for DNAJC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0016020 membrane NAS 9473517
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DNAJC4: view

Pathways & Interactions for DNAJC4 Gene

SuperPathways for DNAJC4 Gene

No Data Available

PCR Array Products

Gene Ontology (GO) - Biological Process for DNAJC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding NAS 9473517
GO:0006986 response to unfolded protein TAS 9473517
genes like me logo Genes that share ontologies with DNAJC4: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJC4 Gene

Drugs & Compounds for DNAJC4 Gene

No Compound Related Data Available

Transcripts for DNAJC4 Gene

Unigene Clusters for DNAJC4 Gene

DnaJ (Hsp40) homolog, subfamily C, member 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJC4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e · 11f
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - -
SP8: - -
SP9: - - - - - - - - - - -
SP11: -
SP13: - - - - - - - - - - - - - -

Relevant External Links for DNAJC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJC4 Gene

mRNA expression in normal human tissues for DNAJC4 Gene

mRNA differential expression in normal tissues according to GTEx for DNAJC4 Gene

This gene is overexpressed in Testis (x4.8).

SOURCE GeneReport for Unigene cluster for DNAJC4 Gene Hs.172847

genes like me logo Genes that share expression patterns with DNAJC4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DNAJC4 Gene

Orthologs for DNAJC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAJC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DNAJC4 35
  • 84.6 (n)
  • 78.17 (a)
  • 72 (a)
(Canis familiaris)
Mammalia DNAJC4 35
  • 84.94 (n)
  • 77.16 (a)
  • 72 (a)
(Mus musculus)
Mammalia Dnajc4 35
  • 78.32 (n)
  • 72.57 (a)
Dnajc4 16
Dnajc4 36
  • 69 (a)
(Pan troglodytes)
Mammalia DNAJC4 35
  • 99.45 (n)
  • 99.17 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Dnajc4 35
  • 78.48 (n)
  • 71.84 (a)
(Monodelphis domestica)
Mammalia DNAJC4 36
  • 58 (a)
(Anolis carolinensis)
Reptilia DNAJC4 36
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc4 35
  • 55.02 (n)
  • 47.59 (a)
(Danio rerio)
Actinopterygii dnajc4 35
  • 55.86 (n)
  • 48.9 (a)
dnajc4 36
  • 43 (a)
(Caenorhabditis elegans)
Secernentea dnj-4 36
  • 21 (a)
Species with no ortholog for DNAJC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC4 Gene

Gene Tree for DNAJC4 (if available)
Gene Tree for DNAJC4 (if available)

Paralogs for DNAJC4 Gene

(7) SIMAP similar genes for DNAJC4 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with DNAJC4: view

No data available for Paralogs for DNAJC4 Gene

Variants for DNAJC4 Gene

Sequence variations from dbSNP and Humsavar for DNAJC4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1058137 -- 64,230,913(+) CTCCC(C/G)GCTCC missense, reference
rs3207600 -- 64,230,922(+) CCTCG(A/G)AGCGG missense, reference
rs3741403 -- 64,232,057(-) CACCC(A/G)CCAGA intron-variant
rs3741404 -- 64,231,768(-) GCTGA(C/G)AGGGC intron-variant
rs3741405 -- 64,231,294(-) TTCCT(C/T)CAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC4 Gene

Variant ID Type Subtype PubMed ID
dgv1156n71 CNV Loss 21882294
nsv469961 CNV Loss 18288195
dgv1163n71 CNV Loss 21882294
dgv1164n71 CNV Loss 21882294
dgv1165n71 CNV Loss 21882294
dgv1166n71 CNV Loss 21882294
nsv832186 CNV Loss 17160897
dgv1167n71 CNV Loss 21882294
esv992196 CNV Deletion 20482838
nsv897674 CNV Loss 21882294
nsv897683 CNV Loss 21882294
esv33033 CNV Loss 17666407
esv24861 CNV Gain 19812545

Variation tolerance for DNAJC4 Gene

Residual Variation Intolerance Score: 53.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC4 Gene

Disorders for DNAJC4 Gene

Relevant External Links for DNAJC4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DNAJC4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC4 Gene

Publications for DNAJC4 Gene

  1. Characterisation of a new human and murine member of the DnaJ family of proteins. (PMID: 9473517) Silins G. … Hayward N. (Biochem. Biophys. Res. Commun. 1998) 2 23 67
  2. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K. … Hata M. (Cell Stress Chaperones 2000) 2 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 67

Products for DNAJC4 Gene

Sources for DNAJC4 Gene

Back to Top