DNAJC4 Gene
protein-coding GIFtS: 48
GCID: GC11P063997
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|
DnaJ (Hsp40) homolog, subfamily C, member 4
(Previous symbol: HSPF2)
| |
Aliases
for DNAJC4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DnaJ (Hsp40) Homolog, Subfamily C, Member 41 2 | | Multiple Endocrine Neoplasia Type 1 Candidate Protein Number 182 3 | | HSPF21 2 3 5 | | DANJC42 5 | | MCG181 2 3 | | DnaJ Homolog Subfamily C Member 42 | | DnaJ-Like Protein HSPF22 3 | | Heat Shock 40kD Protein 22 |
Export aliases for DNAJC4 gene to outside databasesPrevious GC identifers: GC11P066510 GC11P065679 GC11P064249 GC11P063773 GC11P063754 GC11P060325 |
Summaries
for DNAJC4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for DNAJC4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DNAJC4 gene promoter:
Max1 ER-alpha RFX1 Pax-5 Pax-2 Pax-2a CP2 SEF-1 (1) AP-2alpha NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DNAJC4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJC4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13DNAJC4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P063997: view genomic region
(about GC identifiers)
Start:
|
63,997,750 bp from pter |
End:
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64,001,758 bp from pter |
Size:
|
4,009 bases |
Orientation:
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plus strand |
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Proteins
for DNAJC4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DNJC4_HUMAN, Q9NNZ3 (See
protein sequence)Recommended Name: DnaJ homolog subfamily C member 4 Size: 241 amino acids; 27593 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=AAB82426.1; Type=Miscellaneous discrepancy; Note=Several sequence rearrangements;
Secondary accessions: O14716Explore the universe of human proteins at neXtProt for DNAJC4: NX_Q9NNZ3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NNZ3
DNAJC4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005519.2
ENSEMBL proteins: ENSP00000396896 ENSP00000347145 ENSP00000445233 ENSP00000320548 ENSP00000444879
Human Recombinant Protein Products for DNAJC4:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
DNAJC4 for ontologies About GeneDecksing
DNAJC4 Antibody Products:
Assay Products for DNAJC4: |
Protein
Domains /
Families
for DNAJC4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DNAJC4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NNZ3ProtoNet protein and cluster: Q9NNZ3 UniProtKB/Swiss-Prot: DNJC4_HUMAN, Q9NNZ3Similarity: Contains 1 J domain |
Function
for DNAJC4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
DNAJC4 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC4 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DNAJC4 (NM_005528) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DNAJC4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC4 |
|
Pathways & Interactions
for DNAJC4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNAJC4
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for DNAJC4 (Q9NNZ33 ENSP000003205484) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
DNAJC4 for ontologies About GeneDecksing
|
Drugs & Compounds
for DNAJC4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DNAJC4
Search CenterWatch for drugs/clinical trials and news about DNAJC4 / DNJC4
|
Transcripts
for DNAJC4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DNAJC4 gene: NM_005528.3 Unigene Cluster for DNAJC4: DnaJ (Hsp40) homolog, subfamily C, member 4 Hs.172847 [show with all ESTs]Unigene Representative Sequence: BE51267611 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000321685(uc001nys.3 uc001nyt.3 uc001nyu.3) ENST00000355040
ENST00000536006 ENST00000321460 ENST00000537109 ENST00000543685 ENST00000543791
ENST00000542376 ENST00000535246 ENST00000538961 ENST00000540945
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC4 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DNAJC4 (NM_005528) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DNAJC4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC4 |
Additional cDNA sequence: AF036874.1 BC010145.2 BC032137.2 BC044584.1 BC051008.1 BC053947.1 BC057849.1 12 DOTS entries: DT.95342162 DT.100791224 DT.100791230 DT.92466582 DT.40235434 DT.92406018 DT.100791222 DT.92466583 DT.85104627 DT.100028323 DT.100791225 DT.100767500 24/242 AceView cDNA sequences (see all 242): BU171233 BE348750 BX282755 AW612053 BM680347 BQ706492 CD674781 BF791671 CR602542 AI620451 BC010145 BM555596 BQ691981 AA554878 BQ183485 CR615814 BC051008 AI078588 CA433750 BE221100 AI150304 BM724189 AI885155 BM981091
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC4 (see all 14) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | · | 11d | · | 11e | · | 11f |
|---|
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| SP1: | | | | | | | - | | - | | - | | | | | | | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | | | | | | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | | | | | | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DNAJC4
|
Expression
for DNAJC4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DNAJC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATGAAAAGG
About this image
See DNAJC4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DNAJC4
SOURCE GeneReport for Unigene cluster: Hs.172847
SABiosciences Expression via Pathway-Focused PCR Arrays including DNAJC4:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNAJC4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DNAJC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAJC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAJC4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC4 |
Orthologs
for DNAJC4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DNAJC4 gene from 5/13 species (see all 13) About this table
ENSEMBL Gene Tree for DNAJC4 (if available)
TreeFam Gene Tree for DNAJC4 (if available) |
Paralogs
for DNAJC4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DNAJC4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DNAJC4 (63997750 - 64001758 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for DNAJC4
1 CNV: 71339
1 Indel: 11057 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNAJC4 |
|
Disorders
/ Diseases
for DNAJC4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DNAJC4 for disorders About GeneDecksing
OMIM gene information: 604189
OMIM disorders: --
4  diseases for DNAJC4: About MalaCardsmultiple endocrine neoplasia wermer syndrome hepatitis b hepatitis
Human Genome Epidemiology (HuGE) Navigator: DNAJC4 (5 documents)
Export disorders for DNAJC4 gene to outside databases
|
Publications
for DNAJC4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DNAJC4 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with DNAJC4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterisation of a new human and murine member of the DnaJ family of proteins. (PubMed id 9473517)1, 2, 3, 9 Silins G.... Hayward N. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PubMed id 11147971)1, 3 Ohtsuka K. and Hata M. (2000)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Regulation of epidermal growth factor receptor traffi cking by lysine deacetylase HDAC6. (PubMed id 20029029)1 Deribe Y.L....Dikic I. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
|
External Searches for DNAJC4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DNAJC4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DNAJC4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DNAJC4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DNAJC4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DNAJC4 gene:
Search GeneIP for patents involving DNAJC4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DNAJC4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DNAJC4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNAJC4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNAJC4 | | | OriGene Protein Over-expression Lysate for DNAJC4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DNAJC4 | | OriGene 3'-UTR Clone for DNAJC4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DNAJC4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNAJC4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJC4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNAJC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAJC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAJC4 |
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 | | | DNAJC4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC4 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC4 |
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