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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DNAJC3 Gene

protein-coding   GIFtS: 56
GCID: GC13P096329

DnaJ (Hsp40) Homolog, Subfamily C, Member 3


(Previous symbol: PRKRI)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DnaJ (Hsp40) Homolog, Subfamily C, Member 31 2     P58IPK2 3
PRKRI1 2 3 5     P582 5
Endoplasmic Reticulum DnaJ Protein 62 3     HP582
Interferon-Induced, Double-Stranded RNA-Activated Protein Kinase Inhibitor2 3     DnaJ Homolog Subfamily C Member 32
Protein Kinase Inhibitor Of 58 KDa2 3     Endoplasmic Reticulum DNA J Domain-Containing Protein 62
Protein Kinase Inhibitor P582 3     ER-Resident Protein ERdj62
ERdj62 3     Protein-Kinase, Interferon-Inducible Double Stranded RNA Dependent
Inhibitor2

External Ids:    HGNC: 94391   Entrez Gene: 56112   Ensembl: ENSG000001025807   OMIM: 6011845   UniProtKB: Q132173   

Export aliases for DNAJC3 gene to outside databases

Previous GC identifers: GC13P094689 GC13P090716 GC13P095166 GC13P094027 GC13P095127 GC13P076927


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DNAJC3 Gene:
This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J
domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins
and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). (provided by RefSeq,
Jul 2010)

GeneCards Summary for DNAJC3 Gene: 
DNAJC3 (DnaJ (Hsp40) homolog, subfamily C, member 3) is a protein-coding gene. Diseases associated with DNAJC3 include influenza, and bipolar disorder, and among its related super-pathways are Activation of Chaperones by IRE1alpha and Post-translational protein modification. GO annotations related to this gene include unfolded protein binding and chaperone binding. An important paralog of this gene is DNAJC7.

UniProtKB/Swiss-Prot: DNJC3_HUMAN, Q13217
Function: Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it
stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of
EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity

Gene Wiki entry for DNAJC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_009952.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DNAJC3 gene promoter:
         E2F-3a   Lmo2   FOXD1   E2F-2   Ik-3   GATA-1   E2F   E2F-1   HFH-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJC3 promoter sequence
   Search SABiosciences Chromatin IP Primers for DNAJC3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32.1   Ensembl cytogenetic band:  13q32.1   HGNC cytogenetic band: 13q32

DNAJC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJC3 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P096329:  view genomic region     (about GC identifiers)

Start:
96,329,393 bp from pter      End:
96,447,243 bp from pter
Size:
117,851 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DNJC3_HUMAN, Q13217 (See protein sequence)
Recommended Name: DnaJ homolog subfamily C member 3 precursor  
Size: 504 amino acids; 57580 Da
Subunit: Interacts with EIF2AK3 (By similarity) and EIF2AK2. Forms a trimeric complex with DNAJB1 and HSPA8.
Interacts with PRKRIR/P52RIPK
Subcellular location: Endoplasmic reticulum (By similarity)
2 PDB 3D structures from and Proteopedia for DNAJC3:
2Y4T (3D)        2Y4U (3D)    
Secondary accessions: Q86WT9 Q8N4N2

Explore the universe of human proteins at neXtProt for DNAJC3: NX_Q13217

Explore proteomics data for DNAJC3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13217

  • DNAJC3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DNAJC3 Protein Expression
    REFSEQ proteins: NP_006251.1  
    ENSEMBL proteins: 
     ENSP00000473631   ENSP00000365991  
    Reactome Protein details: Q13217
    Human Recombinant Protein Products for DNAJC3: 
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    Novus Biologicals DNAJC3 Protein
    Novus Biologicals DNAJC3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DNAJC3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS8666242
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0031205endoplasmic reticulum Sec complex ----

    DNAJC3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DNAJ: Heat shock proteins / DNAJ (HSP40)
    TTC: Tetratricopeptide (TTC) repeat domain containing

    5/6 InterPro protein domains (see all 6):
     IPR011990 TPR-like_helical
     IPR001440 TPR-1
     IPR026901 DNAJC3
     IPR001623 DnaJ_domain
     IPR013026 TPR-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q13217

    ProtoNet protein and cluster: Q13217

    UniProtKB/Swiss-Prot: DNJC3_HUMAN, Q13217
    Domain: The J domain mediates interaction with HSPA8
    Domain: Binding to misfolded proteins is mediated by a hydrophobic patch forming a large groove within the first
    two TPR repeats (By similarity)
    Similarity: Contains 1 J domain
    Similarity: Contains 9 TPR repeats


    DNAJC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DNJC3_HUMAN, Q13217
    Function: Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it
    stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of
    EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity
    Induction: Up-regulated during an endoplasmic reticulum stress via ATF6. Activated in response to infection by
    influenza virus through the dissociation of DNAJB1. Down-regulated by DNAJB1 and PRKRIR/P52RIPK

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004860protein kinase inhibitor activity TAS7511204
    GO:0005515protein binding ----
    GO:0051087chaperone binding ----
    GO:0051787misfolded protein binding ----
         
    DNAJC3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DNAJC3:
     Decreased telomerase activity 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dnajc3):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     mortality/aging  nervous system  renal/urinary system 

    DNAJC3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dnajc3tm8663Wcl for DNAJC3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DNAJC3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DNAJC3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DNAJC3 
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    hsa-miR-548j hsa-miR-607 hsa-miR-128 hsa-miR-3653 hsa-miR-489 hsa-miR-29a* hsa-miR-548a-5p hsa-miR-200b
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DNAJC3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Activation of Chaperone Genes by XBP1(S)
    Activation of Chaperones by IRE1alpha0.94
    Unfolded Protein Response0.76
    Activation of Chaperone Genes by XBP1(S)0.94
    2Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    3Influenza A
    Influenza A0.34
    4Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum
    5Translational Control
    Translational Control

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for DNAJC3
        Translational Control

    4        Reactome Pathways for DNAJC3
        Activation of Chaperone Genes by XBP1(S)
    Metabolism of proteins
    Activation of Chaperones by IRE1alpha
    Unfolded Protein Response


    2         Kegg Pathways  (Kegg details for DNAJC3):
        Protein processing in endoplasmic reticulum
    Influenza A


    DNAJC3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DNAJC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/34 Interacting proteins for DNAJC3 (Q132173 ENSP000003659914) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000234475P081073, ENSP000004089074I2D: score=1 STRING: ENSP00000408907
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006469negative regulation of protein kinase activity TAS7511204
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0030968endoplasmic reticulum unfolded protein response TAS--
    GO:0044267cellular protein metabolic process TAS--
    GO:0051603proteolysis involved in cellular protein catabolic process ----

    DNAJC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DNAJC3 (DNJC3)

    Search CenterWatch for drugs/clinical trials and news about DNAJC3 / DNJC3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DNAJC3 gene: 
    NM_006260.4  

    Unigene Cluster for DNAJC3:

    DnaJ (Hsp40) homolog, subfamily C, member 3
    Hs.59214  [show with all ESTs]
    Unigene Representative Sequence: NM_006260
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000602402 ENST00000376795(uc001vmp.3 uc001vmq.3)
    miRNA
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    8/87 QIAGEN miScript miRNA Assays for microRNAs that regulate DNAJC3 (see all 87):
    hsa-miR-548j hsa-miR-607 hsa-miR-128 hsa-miR-3653 hsa-miR-489 hsa-miR-29a* hsa-miR-548a-5p hsa-miR-200b
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAJC3

    Additional mRNA sequence: 

    AF339773.1 AF339835.1 AK024941.1 AK292947.1 AK312861.1 BC047936.1 

    11 DOTS entries:

    DT.217239  DT.117001  DT.120762828  DT.100654235  DT.95234317  DT.101960859  DT.91909263  DT.91960825 
    DT.95080915  DT.120762829  DT.120762831 

    24/246 AceView cDNA sequences (see all 246):

    BQ010732 BI713141 BP359894 BU680178 BI907769 AI279565 AI363175 AL079621 
    AA292821 BQ269758 AW613008 AA702140 AJ705622 BX280165 AI090642 CF128313 
    CD365295 BQ027215 AI355263 AF339776 BU625494 CA489509 AA927453 AA004562 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DNAJC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTACAAATA
    DNAJC3 Expression
    About this image


    See DNAJC3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DNAJC3

    SOURCE GeneReport for Unigene cluster: Hs.59214

    UniProtKB/Swiss-Prot: DNJC3_HUMAN, Q13217
    Tissue specificity: Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with
    different levels

        SABiosciences Expression via Pathway-Focused PCR Arrays including DNAJC3: 
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              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DNAJC3 gene from 8/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnajc31 , 5 DnaJ (Hsp40) homolog, subfamily C, member 31, 5 87.5(n)1
    96.83(a)1
      14 (62.60 cM)5
    1000372581  NM_008929.31  NP_032955.21 
     1189379325 
    chicken
    (Gallus gallus)
    Aves DNAJC31 DnaJ (Hsp40) homolog, subfamily C, member 3 77.16(n)
    80.48(a)
      418787  NM_001008437.1  NP_001008437.1 
    lizard
    (Anolis carolinensis)
    Reptilia DNAJC36
    --
    Uncharacterized protein
    75(a)
    57(a)
    1 ↔ 1
    possible ortholog
    3(85358907-85414968)
    GL343220.1(65313-78262)
    African clawed frog
    (Xenopus laevis)
    Amphibia cg8286-prov2 DnaJ (Hsp40) homolog, subfamily C, member 3 77.76(n)    BC044037.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb64f062 wufb64f06 74.29(n)   322544  BC049406.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG82863
    P58IPK1
    protein kinase inhibitor3
    CG8286-PA1
    44(a)3
    51.23(n)1
    45.89(a)1
      85D273
    411611  NM_141659.31  NP_649916.11 
    worm
    (Caenorhabditis elegans)
    Secernentea dnj-71 Protein DNJ-7 53.16(n)
    46.71(a)
      180983  NM_076808.3  NP_509209.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes JEM16
    DnaJ-like chaperone required for nuclear membrane ...
    10(a)
    1 → many
    X(303181-305118)


    ENSEMBL Gene Tree for DNAJC3 (if available)
    TreeFam Gene Tree for DNAJC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DNAJC3 gene
    DNAJC72  

    DNAJC3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2203 SNPs in DNAJC3 are shown (see all 2203)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1423166001,2
    --96331167(+) ATTTCC/TCAGAG 1 -- int10--------
    rs725149911,2
    C--96331446(+) AAAAA-/TTCAGC 1 -- int10--------
    rs678728161,2
    C--96331447(+) AAAAAT/-CAGCA 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs681190421,2
    C--96331474(-) ATTAC-/A/AAAA
            
    AAAAA
    1 -- int11NA 2
    rs782241491,2
    C--96331475(+) TTTTTG/TTAATT 1 -- int11Minor allele frequency- T:0.50NA 2
    rs95619281,2
    C--96331476(+) TTTTGG/TAATTA 1 -- int11Minor allele frequency- T:0.50NA 2
    rs1896818311,2
    --96331484(+) TTAACA/GAGAAG 1 -- int10--------
    rs1467924931,2
    C--96331499(+) TTTCCC/TGGGAG 1 -- int10--------
    rs735505071,2
    C,F--96331528(+) CAAACT/GTGAGT 1 -- int12Minor allele frequency- G:0.10WA 120
    rs1121001711,2
    C--96331560(+) AGGGCT/-TTTTA 1 -- int11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for DNAJC3 (96329393 - 96447243 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for DNAJC3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2747849CNV Deletion23290073
    dgv375e199CNV Deletion23128226
    esv272032CNV Insertion20981092
    esv272164CNV Insertion20981092
    nsv507726CNV Insertion20534489
    nsv832690CNV Gain+Loss17160897
    nsv7246OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601184    OMIM disorders: --

    8 diseases for DNAJC3:    About MalaCards
    influenza    bipolar disorder    hepatitis b    schizophrenia
    retinitis    hepatitis    endotheliitis    breast cancer


    DNAJC3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for DNAJC3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    influenza 53.2 7 9920933 (3), 8910500 (1), 7511204 (1), 10766025 (1)
    virus infection 34.4 1 9920933 (1)

    Genetic Association Database (GAD): DNAJC3
    Human Genome Epidemiology (HuGE) Navigator: DNAJC3 (1 document)

    Export disorders for DNAJC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DNAJC3 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with DNAJC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity. (PubMed id 9920933)1, 2, 9 Melville M.W....Katze M.G. (1999)
    2. The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity. (PubMed id 8576172)1, 2, 9 Polyak S.J.... Katze M.G. (1996)
    3. Cloning, expression, and cellular localization of the oncogenic 58- kDa inhibitor of the RNA-activated human and mouse protein kinase. (PubMed id 8666242)1, 2, 9 Korth M.J.... Katze M.G. (1996)
    4. P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling. (PubMed id 12601012)1, 2, 9 van Huizen R.... Holbrook N.J. (2003)
    5. The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins. (PubMed id 7511204)1, 3, 9 Lee T.G....Katze M.G. (1994)
    6. The crystal structure of the human co-chaperone P58(I PK). (PubMed id 21799829)1, 2 SvAord M....Guy J.E. (2011)
    7. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK. (PubMed id 9447982)1, 2 Gale M.J. Jr.... Katze M.G. (1998)
    10. Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q. (PubMed id 8824806)1, 3 Scherer S.W....Tsui L.C. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5611 HGNC: 9439 AceView: DNAJC3 Ensembl:ENSG00000102580 euGenes: HUgn5611
    ECgene: DNAJC3 Kegg: 5611 H-InvDB: DNAJC3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DNAJC3 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/dnajc3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DNAJC3 gene:
    Search GeneIP for patents involving DNAJC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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