Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DNAJC3 Gene

Aliases for DNAJC3 Gene

  • DnaJ (Hsp40) Homolog, Subfamily C, Member 3 2 3
  • PRKRI 3 4 6
  • Interferon-Induced, Double-Stranded RNA-Activated Protein Kinase Inhibitor 3 4
  • Endoplasmic Reticulum DNA J Domain-Containing Protein 6 3 4
  • Protein Kinase Inhibitor Of 58 KDa 3 4
  • Protein Kinase Inhibitor P58 3 4
  • ER-Resident Protein ERdj6 3 4
  • P58IPK 3 4
  • ERdj6 3 4
  • P58 3 6
  • Protein-Kinase, Interferon-Inducible Double Stranded RNA Dependent Inhibitor 3
  • DnaJ Homolog Subfamily C Member 3 3
  • ACPHD 3
  • HP58 3

External Ids for DNAJC3 Gene

Previous Symbols for DNAJC3 Gene


Summaries for DNAJC3 Gene

Entrez Gene Summary for DNAJC3 Gene

  • This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]

GeneCards Summary for DNAJC3 Gene

DNAJC3 (DnaJ (Hsp40) Homolog, Subfamily C, Member 3) is a Protein Coding gene. Diseases associated with DNAJC3 include ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include protein kinase inhibitor activity. An important paralog of this gene is DNAJC7.

UniProtKB/Swiss-Prot for DNAJC3 Gene

  • Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.

Gene Wiki entry for DNAJC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC3 Gene

Genomics for DNAJC3 Gene

Genomic Location for DNAJC3 Gene

95,677,139 bp from pter
95,794,989 bp from pter
117,851 bases
Plus strand

Genomic View for DNAJC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC3 Gene

Regulatory Elements for DNAJC3 Gene

Proteins for DNAJC3 Gene

  • Protein details for DNAJC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily C member 3
    Protein Accession:
    Secondary Accessions:
    • Q86WT9
    • Q8N4N2

    Protein attributes for DNAJC3 Gene

    504 amino acids
    Molecular mass:
    57580 Da
    Quaternary structure:
    • Interacts with EIF2AK3 (By similarity) and EIF2AK2. Forms a trimeric complex with DNAJB1 and HSPA8. Interacts with PRKRIR/P52RIPK.

    Three dimensional structures from OCA and Proteopedia for DNAJC3 Gene

neXtProt entry for DNAJC3 Gene

Proteomics data for DNAJC3 Gene at MOPED

Post-translational modifications for DNAJC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJC3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJC3 Gene

Domains for DNAJC3 Gene

Gene Families for DNAJC3 Gene

  • TTC :Tetratricopeptide (TTC) repeat domain containing
  • DNAJ :Heat shock proteins / DNAJ (HSP40)

Protein Domains for DNAJC3 Gene


  • The J domain mediates interaction with HSPA8:
    • Q13217
  • Binding to misfolded proteins is mediated by a hydrophobic patch forming a large groove within the first two TPR repeats.:
    • Q13217
  • Contains 1 J domain.:
    • Q13217
  • Contains 9 TPR repeats.:
    • Q13217
genes like me logo Genes that share domains with DNAJC3: view

Function for DNAJC3 Gene

Molecular function for DNAJC3 Gene

UniProtKB/Swiss-Prot Function: Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.
UniProtKB/Swiss-Prot Induction: Up-regulated during an endoplasmic reticulum stress via ATF6. Activated in response to infection by influenza virus through the dissociation of DNAJB1. Down-regulated by DNAJB1 and PRKRIR/P52RIPK.

Gene Ontology (GO) - Molecular Function for DNAJC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity TAS 7511204
GO:0005515 protein binding --
GO:0051087 chaperone binding IEA --
GO:0051787 misfolded protein binding IEA --
genes like me logo Genes that share ontologies with DNAJC3: view
genes like me logo Genes that share phenotypes with DNAJC3: view

Animal Models for DNAJC3 Gene

MGI Knock Outs for DNAJC3:

miRNA for DNAJC3 Gene

miRTarBase miRNAs that target DNAJC3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DNAJC3 Gene

Localization for DNAJC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC3 Gene

Endoplasmic reticulum.

Subcellular locations from

Jensen Localization Image for DNAJC3 Gene COMPARTMENTS Subcellular localization image for DNAJC3 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 2
golgi apparatus 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DNAJC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 8666242
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005790 smooth endoplasmic reticulum IEA --
GO:0016020 membrane IDA 19946888
GO:0031205 endoplasmic reticulum Sec complex IEA --
genes like me logo Genes that share ontologies with DNAJC3: view

Pathways for DNAJC3 Gene

genes like me logo Genes that share pathways with DNAJC3: view

Pathways by source for DNAJC3 Gene

Gene Ontology (GO) - Biological Process for DNAJC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity TAS 7511204
GO:0006987 activation of signaling protein activity involved in unfolded protein response --
GO:0030968 endoplasmic reticulum unfolded protein response TAS --
GO:0036498 IRE1-mediated unfolded protein response TAS --
GO:0043066 negative regulation of apoptotic process IMP 22064321
genes like me logo Genes that share ontologies with DNAJC3: view

Transcripts for DNAJC3 Gene

mRNA/cDNA for DNAJC3 Gene

Unigene Clusters for DNAJC3 Gene

DnaJ (Hsp40) homolog, subfamily C, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC3 Gene

No ASD Table

Relevant External Links for DNAJC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJC3 Gene

mRNA expression in normal human tissues for DNAJC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJC3 Gene

SOURCE GeneReport for Unigene cluster for DNAJC3 Gene Hs.59214

mRNA Expression by UniProt/SwissProt for DNAJC3 Gene

Tissue specificity: Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels.
genes like me logo Genes that share expressions with DNAJC3: view

Orthologs for DNAJC3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNAJC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DNAJC3 36
  • 99.67 (n)
  • 99.8 (a)
  • 100 (a)
(Bos Taurus)
Mammalia DNAJC3 36
  • 92.46 (n)
  • 96.23 (a)
  • 96 (a)
(Canis familiaris)
Mammalia DNAJC3 36
  • 94.27 (n)
  • 97.48 (a)
  • 94 (a)
(Mus musculus)
Mammalia Dnajc3 36
  • 87.5 (n)
  • 96.83 (a)
Dnajc3 16
Dnajc3 37
  • 97 (a)
(Monodelphis domestica)
Mammalia DNAJC3 37
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 84 (a)
-- 37
  • 85 (a)
-- 37
  • 90 (a)
(Rattus norvegicus)
Mammalia Dnajc3 36
  • 86.84 (n)
  • 94.05 (a)
(Gallus gallus)
Aves DNAJC3 36
  • 77.16 (n)
  • 80.48 (a)
  • 80 (a)
(Anolis carolinensis)
Reptilia DNAJC3 37
  • 76 (a)
African clawed frog
(Xenopus laevis)
Amphibia cg8286-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc3 36
  • 71.3 (n)
  • 72.2 (a)
Str.4731 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1207 36
(Danio rerio)
Actinopterygii dnajc3 37
  • 71 (a)
dnajc3a 36
  • 67.79 (n)
  • 71.77 (a)
wufb64f06 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002752 36
  • 51.46 (n)
  • 47.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta P58IPK 36
  • 51.05 (n)
  • 45.8 (a)
P58IPK 37
  • 42 (a)
CG8286 38
  • 44 (a)
(Caenorhabditis elegans)
Secernentea dnj-28 37
  • 41 (a)
dnj-7 36
  • 53.16 (n)
  • 47.12 (a)
dnj-7 37
  • 45 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02424 36
  • 43.36 (n)
  • 35.18 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9325 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8738 37
  • 44 (a)
Species with no ortholog for DNAJC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC3 Gene

Gene Tree for DNAJC3 (if available)
Gene Tree for DNAJC3 (if available)

Paralogs for DNAJC3 Gene

Paralogs for DNAJC3 Gene

genes like me logo Genes that share paralogs with DNAJC3: view

Variants for DNAJC3 Gene

Sequence variations from dbSNP and Humsavar for DNAJC3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs8195 -- 95,794,800(-) AGCAA(A/G)AGTAA utr-variant-3-prime
rs1044259 -- 95,763,919(-) GCCTC(A/T)GCTCG reference, synonymous-codon
rs1151362 -- 95,715,968(+) cctgg(A/C)caaca intron-variant
rs1212830 -- 95,691,993(+) gagct(C/G)agatg intron-variant
rs2289812 -- 95,787,834(-) CCAGG(C/G)CATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC3 Gene

Variant ID Type Subtype PubMed ID
nsv7246 OTHER Inversion 18451855
nsv832690 CNV Gain+Loss 17160897
esv272164 CNV Insertion 20981092
esv272032 CNV Insertion 20981092
esv2747849 CNV Deletion 23290073
nsv507726 CNV Insertion 20534489
dgv375e199 CNV Deletion 23128226

Relevant External Links for DNAJC3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for DNAJC3 Gene


  • Ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus (ACPHD) [MIM:616192]: A disease characterized by juvenile-onset diabetes and neurodegeneration, resulting in ataxia, upper-motor-neuron damage, peripheral neuropathy, hearing loss, and cerebral atrophy. {ECO:0000269 PubMed:25466870}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) Novoseek inferred disease relationships for DNAJC3 Gene

Disease -log(P) Hits PubMed IDs
influenza 53.2 6
virus infection 34.4 1

Relevant External Links for DNAJC3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DNAJC3: view

Publications for DNAJC3 Gene

  1. The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins. (PMID: 7511204) Lee T.G. … Katze M.G. (Mol. Cell. Biol. 1994) 2 3 23
  2. The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity. (PMID: 8576172) Polyak S.J. … Katze M.G. (J. Biol. Chem. 1996) 3 4 23
  3. Cloning, expression, and cellular localization of the oncogenic 58- kDa inhibitor of the RNA-activated human and mouse protein kinase. (PMID: 8666242) Korth M.J. … Katze M.G. (Gene 1996) 3 4 23
  4. The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity. (PMID: 9920933) Melville M.W. … Katze M.G. (J. Biol. Chem. 1999) 3 4 23
  5. P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling. (PMID: 12601012) van Huizen R. … Holbrook N.J. (J. Biol. Chem. 2003) 3 4 23

Products for DNAJC3 Gene

  • antibodies-online proteins for DNAJC3
  • antibodies-online antibodies for DNAJC3
  • antibodies-online kits for DNAJC3

Sources for DNAJC3 Gene

Back to Top