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DNAJC3 Gene

protein-coding   GIFtS: 57
GCID: GC13P096329

DnaJ (Hsp40) Homolog, Subfamily C, Member 3


(Previous symbol: PRKRI)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DnaJ (Hsp40) Homolog, Subfamily C, Member 31 2     P58IPK2 3
PRKRI1 2 3 5     ER-Resident Protein ERdj62 3
Endoplasmic Reticulum DNA J Domain-Containing Protein 62 3     P582 5
Interferon-Induced, Double-Stranded RNA-Activated Protein Kinase Inhibitor2 3     HP582
Protein Kinase Inhibitor Of 58 KDa2 3     DnaJ Homolog Subfamily C Member 32
Protein Kinase Inhibitor P582 3     Endoplasmic Reticulum DnaJ Protein 62
ERdj62 3     Protein-Kinase, Interferon-Inducible Double Stranded RNA Dependent
Inhibitor2

External Ids:    HGNC: 94391   Entrez Gene: 56112   Ensembl: ENSG000001025807   OMIM: 6011845   UniProtKB: Q132173   

Export aliases for DNAJC3 gene to outside databases

Previous GC identifers: GC13P094689 GC13P090716 GC13P095166 GC13P094027 GC13P095127 GC13P076927


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNAJC3 Gene:
This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J
domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins
and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). (provided by RefSeq,
Jul 2010)

GeneCards Summary for DNAJC3 Gene:
DNAJC3 (DnaJ (Hsp40) homolog, subfamily C, member 3) is a protein-coding gene. Diseases associated with DNAJC3 include influenza, and bipolar disorder. GO annotations related to this gene include protein kinase inhibitor activity. An important paralog of this gene is DNAJC7.

UniProtKB/Swiss-Prot: DNJC3_HUMAN, Q13217
Function: Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it
stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of
EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity

Gene Wiki entry for DNAJC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_009952.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAJC3 gene promoter:
         E2F-3a   Lmo2   FOXD1   E2F-2   Ik-3   GATA-1   E2F   E2F-1   HFH-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJC3 promoter sequence
   Search Chromatin IP Primers for DNAJC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAJC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32.1   Ensembl cytogenetic band:  13q32.1   HGNC cytogenetic band: 13q32

DNAJC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJC3 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P096329:  view genomic region     (about GC identifiers)

Start:
96,329,393 bp from pter      End:
96,447,243 bp from pter
Size:
117,851 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DNJC3_HUMAN, Q13217 (See protein sequence)
Recommended Name: DnaJ homolog subfamily C member 3 precursor  
Size: 504 amino acids; 57580 Da
Subunit: Interacts with EIF2AK3 (By similarity) and EIF2AK2. Forms a trimeric complex with DNAJB1 and HSPA8.
Interacts with PRKRIR/P52RIPK
2 PDB 3D structures from and Proteopedia for DNAJC3:
2Y4T (3D)        2Y4U (3D)    
Secondary accessions: Q86WT9 Q8N4N2

Explore the universe of human proteins at neXtProt for DNAJC3: NX_Q13217

Explore proteomics data for DNAJC3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DNAJC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006251.1  
    ENSEMBL proteins: 
     ENSP00000473631   ENSP00000365991  
    Reactome Protein details: Q13217

    DNAJC3 Human Recombinant Protein Products:

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    Novus Biologicals DNAJC3 Protein
    Novus Biologicals DNAJC3 Lysate
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    Cloud-Clone Corp. Proteins for DNAJC3

    DNAJC3 Antibody Products:

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    DNAJC3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for DNAJC3
    Cloud-Clone Corp. CLIAs for DNAJC3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DNAJ: Heat shock proteins / DNAJ (HSP40)
    TTC: Tetratricopeptide (TTC) repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR011990 TPR-like_helical
     IPR001440 TPR_1
     IPR026901 DNAJC3
     IPR001623 DnaJ_domain
     IPR013026 TPR-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q13217

    ProtoNet protein and cluster: Q13217

    UniProtKB/Swiss-Prot: DNJC3_HUMAN, Q13217
    Domain: The J domain mediates interaction with HSPA8
    Domain: Binding to misfolded proteins is mediated by a hydrophobic patch forming a large groove within the first
    two TPR repeats (By similarity)
    Similarity: Contains 1 J domain
    Similarity: Contains 9 TPR repeats


    DNAJC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DNJC3_HUMAN, Q13217
    Function: Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it
    stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of
    EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity
    Induction: Up-regulated during an endoplasmic reticulum stress via ATF6. Activated in response to infection by
    influenza virus through the dissociation of DNAJB1. Down-regulated by DNAJB1 and PRKRIR/P52RIPK

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004860protein kinase inhibitor activity TAS7511204
    GO:0005515protein binding ----
    GO:0051087chaperone binding IEA--
    GO:0051787misfolded protein binding IEA--
         
    DNAJC3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DNAJC3:
     Decreased telomerase activity 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dnajc3):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     mortality/aging  nervous system  renal/urinary system 

    DNAJC3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dnajc3tm8663Wcl for DNAJC3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNAJC3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DNAJC3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DNAJC3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DNAJC3

    miRNA
    Products:
        
    miRTarBase miRNAs that target DNAJC3:
    hsa-mir-30a-5p (MIRT028642), hsa-mir-192-5p (MIRT026830), hsa-mir-335-5p (MIRT018911)

    Block miRNA regulation of human, mouse, rat DNAJC3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAJC3 (see all 87):
    hsa-miR-548j hsa-miR-607 hsa-miR-128 hsa-miR-3653 hsa-miR-489 hsa-miR-29a* hsa-miR-548a-5p hsa-miR-200b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DNAJC3

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for DNAJC3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DNAJC3 (NM_006260)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DNAJC3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DNJC3_HUMAN, Q13217: Endoplasmic reticulum (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    extracellular2
    golgi apparatus1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS8666242
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0031205endoplasmic reticulum Sec complex IEA--
    GO:0070062extracellular vesicular exosome IDA19199708

    DNAJC3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DNAJC3 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Influenza Life Cycle0.82
    Influenza Viral RNA Transcription and Replication0.90
    Influenza Infection0.80
    2Unfolded Protein Response
    Unfolded Protein Response0.61
    Activation of Chaperone Genes by XBP1(S)0.59
    Activation of Chaperones by IRE1alpha0.61
    3Influenza A
    Influenza A0.34
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Translational Control
    Translational Control

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for DNAJC3
        Translational Control

    2 Reactome Pathways for DNAJC3
        Viral mRNA Translation
    XBP1(S) activates chaperone genes


    2 Kegg Pathways  (Kegg details for DNAJC3):
        Protein processing in endoplasmic reticulum
    Influenza A


    DNAJC3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJC3: 
              Hepatotoxicity in human mouse rat
              Unfolded Protein Response in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DNAJC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNAJC3 (Q132173 ENSP000003659914) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000234475P081073, ENSP000004089074I2D: score=1 STRING: ENSP00000408907
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006469negative regulation of protein kinase activity TAS7511204
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0030968endoplasmic reticulum unfolded protein response TAS--
    GO:0044267cellular protein metabolic process TAS--
    GO:0051603proteolysis involved in cellular protein catabolic process IEA--

    DNAJC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNAJC3 (DNJC3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DNAJC3 gene: 
    NM_006260.4  

    Unigene Cluster for DNAJC3:

    DnaJ (Hsp40) homolog, subfamily C, member 3
    Hs.59214  [show with all ESTs]
    Unigene Representative Sequence: NM_006260
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000602402 ENST00000376795(uc001vmp.3 uc001vmq.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DNAJC3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAJC3 (see all 87):
    hsa-miR-548j hsa-miR-607 hsa-miR-128 hsa-miR-3653 hsa-miR-489 hsa-miR-29a* hsa-miR-548a-5p hsa-miR-200b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for DNAJC3
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJC3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAJC3
      QuantiTect SYBR Green Assays in human, mouse, rat DNAJC3
      QuantiFast Probe-based Assays in human, mouse, rat DNAJC3

    Additional mRNA sequence: 

    AF339773.1 AF339835.1 AK024941.1 AK292947.1 AK312861.1 BC047936.1 

    11 DOTS entries:

    DT.217239  DT.117001  DT.120762828  DT.100654235  DT.95234317  DT.101960859  DT.91909263  DT.91960825 
    DT.95080915  DT.120762829  DT.120762831 

    Selected AceView cDNA sequences (see all 246):

    CR601256 BP359894 BX439459 AA031304 CB216160 BI861791 BQ027215 AI912051 
    BX119467 BU625494 W60504 CA489509 AW241647 BI713141 AI186280 NM_006260 
    AI090642 AA004562 AF339835 BQ010732 AA927453 BX489841 AA505821 AI795973 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNAJC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTACAAATA
    DNAJC3 Expression
    About this image


    DNAJC3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Thyroid (Endocrine System)
    DNAJC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAJC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.59214

    UniProtKB/Swiss-Prot: DNJC3_HUMAN, Q13217
    Tissue specificity: Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with
    different levels

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJC3: 
              Hepatotoxicity in human mouse rat
              Unfolded Protein Response in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DNAJC3
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJC3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAJC3
    QuantiTect SYBR Green Assays in human, mouse, rat DNAJC3
    QuantiFast Probe-based Assays in human, mouse, rat DNAJC3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DNAJC3 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnajc31 , 5 DnaJ (Hsp40) homolog, subfamily C, member 31, 5 87.5(n)1
    96.83(a)1
      14 (62.60 cM)5
    1000372581  NM_008929.31  NP_032955.21 
     1189379325 
    chicken
    (Gallus gallus)
    Aves DNAJC31 DnaJ (Hsp40) homolog, subfamily C, member 3 77.16(n)
    80.48(a)
      418787  NM_001008437.1  NP_001008437.1 
    lizard
    (Anolis carolinensis)
    Reptilia DNAJC36
    DnaJ (Hsp40) homolog, subfamily C, member 3
    76(a)
    1 ↔ 1
    3(85358907-85414968)
    African clawed frog
    (Xenopus laevis)
    Amphibia cg8286-prov2 DnaJ (Hsp40) homolog, subfamily C, member 3 77.76(n)    BC044037.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb64f062 wufb64f06 74.29(n)   322544  BC049406.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG82863
    P58IPK1
    protein kinase inhibitor3
    P58IPK1
    44(a)3
    51.05(n)1
    45.8(a)1
      85D273
    411611  NM_141659.41  NP_649916.11 
    worm
    (Caenorhabditis elegans)
    Secernentea dnj-71 dnj-7 53.16(n)
    47.12(a)
      180983  NM_076808.4  NP_509209.1 


    ENSEMBL Gene Tree for DNAJC3 (if available)
    TreeFam Gene Tree for DNAJC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for DNAJC3 gene
    DNAJC72  

    DNAJC3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNAJC3 (see all 2203)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1423166001,2
    --96331167(+) ATTTCC/TCAGAG 1 -- int10--------
    rs725149911,2
    C--96331446(+) AAAAA-/TTCAGC 1 -- int10--------
    rs678728161,2
    C--96331447(+) AAAAAT/-CAGCA 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs681190421,2
    C--96331474(-) ATTAC-/A/AAAA
            
    AAAAA
    1 -- int11NA 2
    rs782241491,2
    C--96331475(+) TTTTTG/TTAATT 1 -- int11Minor allele frequency- T:0.50NA 2
    rs95619281,2
    C--96331476(+) TTTTGG/TAATTA 1 -- int11Minor allele frequency- T:0.50NA 2
    rs1896818311,2
    --96331484(+) TTAACA/GAGAAG 1 -- int10--------
    rs1467924931,2
    C--96331499(+) TTTCCC/TGGGAG 1 -- int10--------
    rs735505071,2
    C,F--96331528(+) CAAACT/GTGAGT 1 -- int12Minor allele frequency- G:0.10WA 120
    rs1121001711,2
    C--96331560(+) AGGGCT/-TTTTA 1 -- int11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for DNAJC3 (96329393 - 96447243 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for DNAJC3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747849CNV Deletion23290073
    dgv375e199CNV Deletion23128226
    esv272032CNV Insertion20981092
    esv272164CNV Insertion20981092
    nsv507726CNV Insertion20534489
    nsv832690CNV Gain+Loss17160897
    nsv7246OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601184    OMIM disorders: --

    9 diseases for DNAJC3:    
    About MalaCards
    influenza    bipolar disorder    hepatitis b    schizophrenia
    retinitis    hepatitis    endotheliitis    breast cancer
    malaria


    DNAJC3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for DNAJC3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    influenza 53.2 7 9920933 (3), 8910500 (1), 7511204 (1), 10766025 (1)
    virus infection 34.4 1 9920933 (1)

    Genetic Association Database (GAD): DNAJC3
    Human Genome Epidemiology (HuGE) Navigator: DNAJC3 (1 document)

    Export disorders for DNAJC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNAJC3 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with DNAJC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity. (PubMed id 9920933)1, 2, 9 Melville M.W....Katze M.G. (J. Biol. Chem. 1999)
    2. The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity. (PubMed id 8576172)1, 2, 9 Polyak S.J.... Katze M.G. (J. Biol. Chem. 1996)
    3. Cloning, expression, and cellular localization of the oncogenic 58- kDa inhibitor of the RNA-activated human and mouse protein kinase. (PubMed id 8666242)1, 2, 9 Korth M.J.... Katze M.G. (Gene 1996)
    4. P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling. (PubMed id 12601012)1, 2, 9 van Huizen R.... Holbrook N.J. (J. Biol. Chem. 2003)
    5. The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins. (PubMed id 7511204)1, 3, 9 Lee T.G....Katze M.G. (Mol. Cell. Biol. 1994)
    6. The crystal structure of the human co-chaperone P58(IPK). (PubMed id 21799829)1, 2 Svard M.... Guy J.E. (PLoS ONE 2011)
    7. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK. (PubMed id 9447982)1, 2 Gale M.J. Jr.... Katze M.G. (Mol. Cell. Biol. 1998)
    10. Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q. (PubMed id 8824806)1, 3 Scherer S.W....Tsui L.C. (Genomics 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5611 HGNC: 9439 AceView: DNAJC3 Ensembl:ENSG00000102580 euGenes: HUgn5611
    ECgene: DNAJC3 Kegg: 5611 H-InvDB: DNAJC3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DNAJC3 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/dnajc3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNAJC3 gene:
    Search GeneIP for patents involving DNAJC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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