Aliases for DNAJC3 Gene
External Ids for DNAJC3 Gene
Previous HGNC Symbols for DNAJC3 Gene
Previous GeneCards Identifiers for DNAJC3 Gene
This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]
GeneCards Summary for DNAJC3 Gene
DNAJC3 (DnaJ (Hsp40) Homolog, Subfamily C, Member 3) is a Protein Coding gene. Diseases associated with DNAJC3 include ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus and influenza. Among its related pathways are Infectious disease and Transport to the Golgi and subsequent modification. GO annotations related to this gene include chaperone binding and misfolded protein binding. An important paralog of this gene is DNAJC7.
UniProtKB/Swiss-Prot for DNAJC3 Gene
Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.