DNAJC28 Gene
protein-coding GIFtS: 45
GCID: GC21M034860
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DnaJ (Hsp40) homolog, subfamily C, member 28(Previous name: chromosome 21 open reading frame 55 )
(Previous symbol: C21orf55)
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Aliases
for DNAJC28 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DnaJ (Hsp40) Homolog, Subfamily C, Member 281 2 | | C21orf551 2 3 | | C21orf781 2 3 | | Chromosome 21 Open Reading Frame 551 | | DnaJ Homolog Subfamily C Member 282 |
Export aliases for DNAJC28 gene to outside databasesPrevious GC identifers: GC21M033782 GC21M020338 |
Summaries
for DNAJC28 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: DJC28_HUMAN, Q9NX36Function: May have a role in protein folding or as a chaperone
Gene Wiki entry for DNAJC28 (C21orf55)
|
Genomic Views
for DNAJC28 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000021.8 NC_018932.1 NT_011512.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DNAJC28 gene promoter:
E2F-1 Ik-2 E2F Pax-6 GATA-1 Arnt
Other transcription factors
Search SABiosciences Chromatin IP Primers for DNAJC28
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJC28 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 21q22.11 Ensembl cytogenetic band: 21q22.11 HGNC cytogenetic band: 21q22.11DNAJC28 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 21 GeneLoc Exon Structure GeneLoc location for GC21M034860: view genomic region
(about GC identifiers)
Start:
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34,860,238 bp from pter |
End:
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34,864,027 bp from pter |
Size:
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3,790 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr21-,PATCHES 34,865,016-34,868,802 |
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Proteins
for DNAJC28 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DJC28_HUMAN, Q9NX36 (See
protein sequence)Recommended Name: DnaJ homolog subfamily C member 28 Size: 388 amino acids; 45806 Da
Developmental stage: Not expressed in 8 and 10 weeks old fetuses
Secondary accessions: D3DSF2Explore the universe of human proteins at neXtProt for DNAJC28: NX_Q9NX36
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NX36
DNAJC28 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001035282.1 NP_060303.2
ENSEMBL proteins: ENSP00000371373 ENSP00000320303 ENSP00000385777
Human Recombinant Protein Products:
DNAJC28 Antibody Products:
Assay Products for DNAJC28: |
Protein
Domains /
Families
for DNAJC28 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DNAJC28 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NX36ProtoNet protein and cluster: Q9NX36 UniProtKB/Swiss-Prot: DJC28_HUMAN, Q9NX36Similarity: Contains 1 J domain |
Function
for DNAJC28 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DJC28_HUMAN, Q9NX36Function: May have a role in protein folding or as a chaperone
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC28 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC28 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for DNAJC28 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC28 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC28 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0031072 | heat shock protein binding |
IEA | -- |
DNAJC28 for ontologies About GeneDecksing
Animal Models:
1 MGI phenotypic allele  for Dnajc28 (no phenotypes)
DNAJC28 for phenotypes About GeneDecksing
|
Pathways & Interactions
for DNAJC28 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNAJC28
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for DNAJC28 (Q9NX362, 3 ENSP000003203034) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for DNAJC28 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DNAJC28
Search CenterWatch for drugs/clinical trials and news about DNAJC28 / DJC28
|
Transcripts
for DNAJC28 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DNAJC28 gene (2 alternative transcripts): NM_001040192.1 NM_017833.3 Unigene Cluster for DNAJC28: DnaJ (Hsp40) homolog, subfamily C, member 28 Hs.458308 [show with all ESTs]Unigene Representative Sequence: NM_0178333 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000381947(uc002yrw.3) ENST00000314399(uc002yrv.3) ENST00000402202
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC28 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC28 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): DNAJC28 (NM_001040192) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DNAJC28 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC28 |
Additional cDNA sequence: AK000468.1 AK225514.1 BC029509.1 2 DOTS entries: DT.453299 DT.99972756 23 AceView cDNA sequences: AF462153 NM_017833 CB241459 AA233864 AI825667 BP369590 AW592095 AI678113 AA757227 BU567944 AA934910 BU621794 BC029509 AK000468 BU942655 AI476498 AA232809 AI004410 BX092464 AI206101 CD698555 BI600694 AA922150
GeneLoc Exon Structure
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Expression
for DNAJC28 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DNAJC28 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAATGAGA
About this image
See DNAJC28 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DNAJC28
SOURCE GeneReport for Unigene cluster: Hs.458308
UniProtKB/Swiss-Prot: DJC28_HUMAN, Q9NX36Tissue specificity: Expressed in the fetal and adult brain, testis, uterus, spleen and liver
SABiosciences Custom PCR Arrays for DNAJC28
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNAJC28
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DNAJC28 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAJC28 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAJC28 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC28 |
Orthologs
for DNAJC28 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DNAJC28 gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for DNAJC28 (if available)
TreeFam Gene Tree for DNAJC28 (if available) |
Paralogs
for DNAJC28 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DNAJC28 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 21 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DNAJC28 (34860238 - 34864027 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for DNAJC28
2 CNVs: 0542 35965 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNAJC28 |
|
Disorders
/ Diseases
for DNAJC28 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DNAJC28 for disorders About GeneDecksing
3  diseases for DNAJC28: About MalaCardsherpes zoster chickenpox down syndrome
2 diseases from the University of Copenhagen DISEASES database for DNAJC28:Chickenpox Herpes zoster Export disorders for DNAJC28 gene to outside databases
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Publications
for DNAJC28 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DNAJC28 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DNAJC28) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis. (PubMed id 12036298)1, 2 Gardiner K....Davisson M. (2002)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction. (PubMed id 17693683)2 Tang L.Y....Zeng R. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The DNA sequence of human chromosome 21. (PubMed id 10830953)1 Hattori M....Yaspo M.L. (2000)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
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External Searches for DNAJC28 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing DNAJC28 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DNAJC28 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DNAJC28 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DNAJC28 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for DNAJC28 gene:
Search GeneIP for patents involving DNAJC28
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DNAJC28 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNAJC28 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNAJC28 | | | OriGene Protein Over-expression Lysate for DNAJC28 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DNAJC28 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC28 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC28 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | DNAJC28 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC28 |
|  |  |  | | | | Search ThermoFisher Antibodies for DNAJC28 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC28 |
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