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Aliases for DNAJC28 Gene

Aliases for DNAJC28 Gene

  • DnaJ (Hsp40) Homolog, Subfamily C, Member 28 2 3
  • C21orf55 3 4
  • C21orf78 3 4
  • Chromosome 21 Open Reading Frame 55 2
  • DnaJ Homolog Subfamily C Member 28 3
  • Orf28 2

External Ids for DNAJC28 Gene

Previous Symbols for DNAJC28 Gene

  • C21orf55

Summaries for DNAJC28 Gene

GeneCards Summary for DNAJC28 Gene

DNAJC28 (DnaJ (Hsp40) Homolog, Subfamily C, Member 28) is a Protein Coding gene. Diseases associated with DNAJC28 include chickenpox.

UniProtKB/Swiss-Prot for DNAJC28 Gene

  • May have a role in protein folding or as a chaperone

Gene Wiki entry for DNAJC28 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC28 Gene

Genomics for DNAJC28 Gene

Genomic Location for DNAJC28 Gene

Start:
33,485,530 bp from pter
End:
33,491,723 bp from pter
Size:
6,194 bases
Orientation:
Minus strand

Genomic View for DNAJC28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJC28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC28 Gene

Regulatory Elements for DNAJC28 Gene

Proteins for DNAJC28 Gene

  • Protein details for DNAJC28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX36-DJC28_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 28
    Protein Accession:
    Q9NX36
    Secondary Accessions:
    • D3DSF2

    Protein attributes for DNAJC28 Gene

    Size:
    388 amino acids
    Molecular mass:
    45806 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DNAJC28 Gene

Proteomics data for DNAJC28 Gene at MOPED

Post-translational modifications for DNAJC28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJC28 Gene

No data available for DME Specific Peptides for DNAJC28 Gene

Domains for DNAJC28 Gene

Gene Families for DNAJC28 Gene

HGNC:
  • DNAJ :Heat shock proteins / DNAJ (HSP40)

Protein Domains for DNAJC28 Gene

UniProtKB/Swiss-Prot:

DJC28_HUMAN
Domain:
  • Contains 1 J domain.:
    • Q9NX36
genes like me logo Genes that share domains with DNAJC28: view

Function for DNAJC28 Gene

Molecular function for DNAJC28 Gene

UniProtKB/Swiss-Prot Function: May have a role in protein folding or as a chaperone

Gene Ontology (GO) - Molecular Function for DNAJC28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24407287
genes like me logo Genes that share ontologies with DNAJC28: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DNAJC28 Gene

Localization for DNAJC28 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJC28 Gene COMPARTMENTS Subcellular localization image for DNAJC28 gene
Compartment Confidence
golgi apparatus 3
mitochondrion 3
nucleus 3
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for DNAJC28 Gene

Pathways for DNAJC28 Gene

SuperPathways for DNAJC28 Gene

No Data Available

Interacting Proteins for DNAJC28 Gene

Selected Interacting proteins: Q9NX36-DJC28_HUMAN for DNAJC28 Gene via MINT I2D

Symbol External ID(s) Details
MAPK6

Gene Ontology (GO) - Biological Process for DNAJC28 Gene

None

No data available for Pathways by source for DNAJC28 Gene

Transcripts for DNAJC28 Gene

Unigene Clusters for DNAJC28 Gene

DnaJ (Hsp40) homolog, subfamily C, member 28:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC28 Gene

No ASD Table

Relevant External Links for DNAJC28 Gene

GeneLoc Exon Structure for
DNAJC28
ECgene alternative splicing isoforms for
DNAJC28

Expression for DNAJC28 Gene

mRNA expression in normal human tissues for DNAJC28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAJC28 Gene

This gene is overexpressed in Testis (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DNAJC28 Gene

SOURCE GeneReport for Unigene cluster for DNAJC28 Gene Hs.458308

mRNA Expression by UniProt/SwissProt for DNAJC28 Gene

Q9NX36-DJC28_HUMAN
Tissue specificity: Expressed in the fetal and adult brain, testis, uterus, spleen and liver
genes like me logo Genes that share expressions with DNAJC28: view

Orthologs for DNAJC28 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAJC28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC28 36
  • 99.48 (n)
  • 98.97 (a)
DNAJC28 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAJC28 36
  • 88.3 (n)
  • 83.11 (a)
DNAJC28 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 82 (a)
OneToMany
-- 37
  • 82 (a)
OneToMany
DNAJC28 36
  • 87.88 (n)
  • 83.9 (a)
mouse
(Mus musculus)
Mammalia Dnajc28 36
  • 78.57 (n)
  • 74.54 (a)
Dnajc28 16
Dnajc28 37
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNAJC28 37
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC28 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajc28 36
  • 78.39 (n)
  • 75.07 (a)
chicken
(Gallus gallus)
Aves C21ORF55 36
  • 67.39 (n)
  • 60.49 (a)
DNAJC28 37
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJC28 37
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc28 36
  • 63.51 (n)
  • 60.06 (a)
zebrafish
(Danio rerio)
Actinopterygii dnajc28 36
  • 55.04 (n)
  • 49.59 (a)
dnajc28 37
  • 47 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009787 36
  • 50.61 (n)
  • 42.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43322 36
  • 49.01 (n)
  • 41.75 (a)
CG43322 37
  • 34 (a)
OneToOne
Species with no ortholog for DNAJC28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAJC28 Gene

ENSEMBL:
Gene Tree for DNAJC28 (if available)
TreeFam:
Gene Tree for DNAJC28 (if available)

Paralogs for DNAJC28 Gene

No data available for Paralogs for DNAJC28 Gene

Variants for DNAJC28 Gene

Sequence variations from dbSNP and Humsavar for DNAJC28 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs743312 -- 33,490,536(+) TAGGA(A/G)GCCGA intron-variant
rs3761346 -- 33,491,682(+) CAGGG(C/G)ACCTC utr-variant-5-prime, upstream-variant-2KB
rs3761347 -- 33,491,977(+) AGGAG(C/T)CACCT upstream-variant-2KB
rs3834674 -- 33,488,450(+) TTAAA(-/TTAAA)ATCAT frameshift-variant, reference
rs4816458 -- 33,487,794(+) tgagc(C/T)gagat downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for DNAJC28 Gene

Variant ID Type Subtype PubMed ID
nsv913724 CNV Loss 21882294
nsv3497 CNV Insertion 18451855
nsv524420 CNV Loss 19592680
nsv509795 CNV Insertion 20534489
nsv191 CNV Insertion 15895083

Relevant External Links for DNAJC28 Gene

HapMap Linkage Disequilibrium report
DNAJC28

Disorders for DNAJC28 Gene

(1) MalaCards Diseases for DNAJC28 Gene

Search for DNAJC28 Gene in MalaCards »

(2) University of Copenhagen DISEASES for DNAJC28 Gene

genes like me logo Genes that share disorders with DNAJC28: view

No data available for UniProtKB/Swiss-Prot for DNAJC28 Gene

Publications for DNAJC28 Gene

  1. Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis. (PMID: 12036298) Gardiner K. … Davisson M. (Genomics 2002) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

Products for DNAJC28 Gene

Sources for DNAJC28 Gene

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