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DNAJC28 Gene

protein-coding   GIFtS: 45
GCID: GC21M034860

DnaJ (Hsp40) Homolog, Subfamily C, Member 28

(Previous name: chromosome 21 open reading frame 55)
(Previous symbol: C21orf55)
  See DNAJC28-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DnaJ (Hsp40) Homolog, Subfamily C, Member 281 2
C21orf551 2 3
C21orf782 3
Orf281
Chromosome 21 Open Reading Frame 551
DnaJ Homolog Subfamily C Member 282

External Ids:    HGNC: 12971   Entrez Gene: 549432   Ensembl: ENSG000001776927   UniProtKB: Q9NX363   

Export aliases for DNAJC28 gene to outside databases

Previous GC identifers: GC21M033782 GC21M020338


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DNAJC28 Gene:
DNAJC28 (DnaJ (Hsp40) homolog, subfamily C, member 28) is a protein-coding gene. Diseases associated with DNAJC28 include chickenpox.

UniProtKB/Swiss-Prot: DJC28_HUMAN, Q9NX36
Function: May have a role in protein folding or as a chaperone

Gene Wiki entry for DNAJC28 (C21orf55) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAJC28 gene promoter:
         E2F-1   Ik-2   E2F   Pax-6   GATA-1   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJC28 promoter sequence
   Search Chromatin IP Primers for DNAJC28

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAJC28


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.11

DNAJC28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJC28 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M034860:  view genomic region     (about GC identifiers)

Start:
34,860,238 bp from pter      End:
34,864,027 bp from pter
Size:
3,790 bases      Orientation:
minus strand

1 alternative location:
Chr21-,NW_003315970 92,061-95,847     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DJC28_HUMAN, Q9NX36 (See protein sequence)
Recommended Name: DnaJ homolog subfamily C member 28  
Size: 388 amino acids; 45806 Da
Developmental stage: Not expressed in 8 and 10 weeks old fetuses
Secondary accessions: D3DSF2

Explore the universe of human proteins at neXtProt for DNAJC28: NX_Q9NX36

Explore proteomics data for DNAJC28 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DNAJC28 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001035282.1  NP_060303.2  

    ENSEMBL proteins: 
     ENSP00000371373   ENSP00000320303   ENSP00000385777  

    DNAJC28 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    2 InterPro protein domains:
     IPR018961 DnaJ_homolog_subfam-C_membr-28
     IPR001623 DnaJ_domain

    Graphical View of Domain Structure for InterPro Entry Q9NX36

    ProtoNet protein and cluster: Q9NX36

    UniProtKB/Swiss-Prot: DJC28_HUMAN, Q9NX36
    Similarity: Contains 1 J domain


    Find genes that share domains with DNAJC28           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DJC28_HUMAN, Q9NX36
    Function: May have a role in protein folding or as a chaperone

    Phenotypes:
         1 MGI phenotypic allele for Dnajc28 (no phenotypes)


    Find genes that share phenotypes with DNAJC28           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNAJC28
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus3
    mitochondrion3
    nucleus3
    cytosol1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DNAJC28
    Interactions:

        Search GeneGlobe Interaction Network for DNAJC28

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for DNAJC28 (Q9NX362, 3 ENSP000003203034) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166592, 3MINT-8260999 I2D: score=2 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNAJC28 (DJC28)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DNAJC28 gene (2 alternative transcripts): 
    NM_001040192.2  NM_017833.4  

    Unigene Cluster for DNAJC28:

    DnaJ (Hsp40) homolog, subfamily C, member 28
    Hs.458308  [show with all ESTs]
    Unigene Representative Sequence: NM_017833
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381947(uc002yrw.3) ENST00000314399(uc002yrv.3) ENST00000402202

    miRNA
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    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC28
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat DNAJC28
      QuantiFast Probe-based Assays in human, mouse, rat DNAJC28

    Additional mRNA sequence: 

    AK000468.1 AK225514.1 BC029509.1 

    2 DOTS entries:

    DT.453299  DT.99972756 

    23 AceView cDNA sequences:

    AF462153 AW592095 AA233864 NM_017833 AI825667 BP369590 CB241459 AA934910 
    AK000468 BU567944 BU942655 BU621794 AA757227 BC029509 AI678113 AI004410 
    CD698555 AI206101 AI476498 BI600694 AA232809 AA922150 BX092464 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNAJC28 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAATGAGA
    DNAJC28 Expression
    About this image


    DNAJC28 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    DNAJC28 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAJC28 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.458308

    UniProtKB/Swiss-Prot: DJC28_HUMAN, Q9NX36
    Tissue specificity: Expressed in the fetal and adult brain, testis, uterus, spleen and liver

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC28

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DNAJC28 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnajc281 , 5 DnaJ (Hsp40) homolog, subfamily C, member 281, 5 78.57(n)1
    74.54(a)1
      16 (53.17 cM)5
    2467381  NM_001099738.11  NP_001093208.11 
     916157265 
    chicken
    (Gallus gallus)
    Aves C21ORF551 DnaJ (Hsp40) homolog, subfamily C, member 28 67.39(n)
    60.49(a)
      770607  XM_004934505.1  XP_004934562.1 
    lizard
    (Anolis carolinensis)
    Reptilia DNAJC286
    DnaJ (Hsp40) homolog, subfamily C, member 28
    57(a)
    1 ↔ 1
    3(143137306-143138659)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dnajc281 DnaJ (Hsp40) homolog, subfamily C, member 28 63.51(n)
    60.06(a)
      548731  NM_001015977.1  NP_001015977.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dnajc281 DnaJ (Hsp40) homolog, subfamily C, member 28 55.04(n)
    49.59(a)
      550341  NM_001017648.1  NP_001017648.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG433221 CG43322 49.01(n)
    41.75(a)
      33984  NM_135248.3  NP_609092.1 


    ENSEMBL Gene Tree for DNAJC28 (if available)
    TreeFam Gene Tree for DNAJC28 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNAJC28 (see all 181)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1503737361,2
    C--34859763(+) AGCCCA/GTAATC 2 -- ds50010--------
    rs1854672261,2
    --34859799(+) GTGGAC/TCATGA 2 -- ds50010--------
    rs1380621701,2
    --34859848(+) ACCCCA/GTCTCT 2 -- ds50010--------
    rs1908198191,2
    --34859870(+) AAAAAC/TAGGCC 2 -- ds50010--------
    rs1495162711,2
    --34859876(+) AGGCCA/TGGCGC 2 -- ds50010--------
    rs1459898671,2
    --34859879(+) CCAGGC/TGCGGT 2 -- ds50010--------
    rs1808213881,2
    --34859880(+) CAGGCA/GCGGTG 2 -- ds50010--------
    rs1842772021,2
    --34859881(+) AGGCGC/TGGTGG 2 -- ds50010--------
    rs1120629771,2
    C--34859888(+) GTGGCG/TCACAC 2 -- ds50010--------
    rs81278011,2
    C,F,H--34859924(+) cgaggT/Cgggcg 2 -- ds50017Minor allele frequency- C:0.14NA WA 14

    HapMap Linkage Disequilibrium report for DNAJC28 (34860238 - 34864027 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DNAJC28:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv191CNV Insertion15895083
    nsv509795CNV Insertion20534489
    nsv3497CNV Insertion18451855
    nsv524420CNV Loss19592680
    nsv913724CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAJC28
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAJC28

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for DNAJC28:    
    About MalaCards
    chickenpox

    2 diseases from the University of Copenhagen DISEASES database for DNAJC28:
    Chickenpox     Herpes zoster

    Find genes that share disorders with DNAJC28           About GenesLikeMe


    Export disorders for DNAJC28 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNAJC28 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with DNAJC28)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis. (PubMed id 12036298)1, 2 Gardiner K.... Davisson M. (Genomics 2002)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    6. Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction. (PubMed id 17693683)2 Tang L.-Y.... Zeng R. (Mol. Cell. Proteomics 2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. The DNA sequence of human chromosome 21. (PubMed id 10830953)1 Hattori M.... Yaspo M.-L. (Nature 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54943 HGNC: 1297 AceView: C21orf55 Ensembl:ENSG00000177692 euGenes: HUgn54943
    ECgene: DNAJC28 H-InvDB: DNAJC28

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DNAJC28 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNAJC28 gene:
    Search GeneIP for patents involving DNAJC28

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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