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Aliases for DNAJC28 Gene

Aliases for DNAJC28 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C28 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 28 2 3
  • C21orf55 3 4
  • C21orf78 3 4
  • Chromosome 21 Open Reading Frame 55 2
  • DnaJ Homolog Subfamily C Member 28 3
  • Orf28 2

External Ids for DNAJC28 Gene

Previous HGNC Symbols for DNAJC28 Gene

  • C21orf55

Previous GeneCards Identifiers for DNAJC28 Gene

  • GC21M033782
  • GC21M034860
  • GC21M020338

Summaries for DNAJC28 Gene

Entrez Gene Summary for DNAJC28 Gene

  • This gene encodes a member of the DnaJ heat shock protein family. The encoded protein, which contains a conserved N-terminal DnaJ domain, is thought to play a role in protein folding or act as a molecular chaperone protein. [provided by RefSeq, Oct 2016]

GeneCards Summary for DNAJC28 Gene

DNAJC28 (DnaJ Heat Shock Protein Family (Hsp40) Member C28) is a Protein Coding gene. Diseases associated with DNAJC28 include Retinitis Pigmentosa 4, Autosomal Dominant Or Recessive.

UniProtKB/Swiss-Prot for DNAJC28 Gene

  • May have a role in protein folding or as a chaperone.

Gene Wiki entry for DNAJC28 Gene

Additional gene information for DNAJC28 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC28 Gene

Genomics for DNAJC28 Gene

Regulatory Elements for DNAJC28 Gene

Enhancers for DNAJC28 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21H033201 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.7 +287.8 287786 4 HDGF PKNOX1 SIN3A DMAP1 ZNF48 YY1 FOS ATF7 ZNF548 RUNX3 SON PAXBP1 TMEM50B EVA1C GART DONSON IFNAR2 IFNGR2 URB1 C21orf59
GH21H033196 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +293.1 293110 4 PKNOX1 ATF1 BRCA1 ZNF2 YY1 ZNF143 FOS ATF7 DEK JUNB IFNAR2 PAXBP1 SON GART LINC01548 IFNGR2 ENSG00000249624 ENSG00000226433 DONSON TMEM50B
GH21H033400 1.7 FANTOM5 ENCODE dbSUPER 10.1 +87.8 87798 6 MLX ARID4B SIN3A ZNF48 ZNF2 YY1 ZNF121 GLIS2 ATF7 RUNX3 IFNGR2 TMEM50B IFNAR2 RPS5P3 ENSG00000231355 ENSG00000249624 DNAJC28 IL10RB GART IFNAR1
GH21H033539 1.4 ENCODE dbSUPER 12 -51.3 -51261 6 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D SSRP1 ZNF610 GLIS1 SON PAXBP1 TMEM50B GART DONSON C21orf140 C21orf59 PAXBP1-AS1 DNAJC28 ENSG00000231355
GH21H033432 1.4 Ensembl ENCODE dbSUPER 10.7 +57.5 57465 3 HDAC1 HDGF PKNOX1 TBL1XR1 SIN3A BATF ZNF121 ZNF766 FOS ETV6 TMEM50B RPS5P3 IFNAR2 DNAJC28 LINC01548 IFNGR2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DNAJC28 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJC28 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000141567 47 1400 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9

Genomic Location for DNAJC28 Gene

Chromosome:
21
Start:
33,485,530 bp from pter
End:
33,491,747 bp from pter
Size:
6,218 bases
Orientation:
Minus strand

Genomic View for DNAJC28 Gene

Genes around DNAJC28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC28 Gene

Proteins for DNAJC28 Gene

  • Protein details for DNAJC28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX36-DJC28_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 28
    Protein Accession:
    Q9NX36
    Secondary Accessions:
    • D3DSF2

    Protein attributes for DNAJC28 Gene

    Size:
    388 amino acids
    Molecular mass:
    45806 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DNAJC28 Gene

Post-translational modifications for DNAJC28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJC28 Gene

No data available for DME Specific Peptides for DNAJC28 Gene

Domains & Families for DNAJC28 Gene

Gene Families for DNAJC28 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DNAJC28 Gene

Suggested Antigen Peptide Sequences for DNAJC28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNAJC28: view

No data available for UniProtKB/Swiss-Prot for DNAJC28 Gene

Function for DNAJC28 Gene

Molecular function for DNAJC28 Gene

UniProtKB/Swiss-Prot Function:
May have a role in protein folding or as a chaperone.

Phenotypes From GWAS Catalog for DNAJC28 Gene

Gene Ontology (GO) - Molecular Function for DNAJC28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24407287
genes like me logo Genes that share ontologies with DNAJC28: view
genes like me logo Genes that share phenotypes with DNAJC28: view

Animal Models for DNAJC28 Gene

MGI Knock Outs for DNAJC28:

Animal Model Products

CRISPR Products

miRNA for DNAJC28 Gene

miRTarBase miRNAs that target DNAJC28

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DNAJC28
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DNAJC28 Gene

Localization for DNAJC28 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJC28 gene
Compartment Confidence
golgi apparatus 4
mitochondrion 3
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for DNAJC28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017119 Golgi transport complex IBA --
genes like me logo Genes that share ontologies with DNAJC28: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for DNAJC28 Gene

Pathways & Interactions for DNAJC28 Gene

SuperPathways for DNAJC28 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJC28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000301 retrograde transport, vesicle recycling within Golgi IBA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IBA --
GO:0007030 Golgi organization IBA --
GO:0048213 Golgi vesicle prefusion complex stabilization IBA --
genes like me logo Genes that share ontologies with DNAJC28: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJC28 Gene

Drugs & Compounds for DNAJC28 Gene

No Compound Related Data Available

Transcripts for DNAJC28 Gene

Unigene Clusters for DNAJC28 Gene

DnaJ (Hsp40) homolog, subfamily C, member 28:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DNAJC28
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC28 Gene

No ASD Table

Relevant External Links for DNAJC28 Gene

GeneLoc Exon Structure for
DNAJC28
ECgene alternative splicing isoforms for
DNAJC28

Expression for DNAJC28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJC28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAJC28 Gene

This gene is overexpressed in Testis (x4.1).

Protein differential expression in normal tissues from HIPED for DNAJC28 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DNAJC28 Gene



Protein tissue co-expression partners for DNAJC28 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJC28 Gene:

DNAJC28

SOURCE GeneReport for Unigene cluster for DNAJC28 Gene:

Hs.458308

mRNA Expression by UniProt/SwissProt for DNAJC28 Gene:

Q9NX36-DJC28_HUMAN
Tissue specificity: Expressed in the fetal and adult brain, testis, uterus, spleen and liver.
genes like me logo Genes that share expression patterns with DNAJC28: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJC28 Gene

Orthologs for DNAJC28 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAJC28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC28 33 34
  • 99.48 (n)
cow
(Bos Taurus)
Mammalia DNAJC28 33 34
  • 88.3 (n)
dog
(Canis familiaris)
Mammalia DNAJC28 33
  • 87.88 (n)
-- 34
  • 82 (a)
OneToMany
-- 34
  • 82 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Dnajc28 33 16 34
  • 78.57 (n)
rat
(Rattus norvegicus)
Mammalia Dnajc28 33
  • 78.39 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC28 34
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNAJC28 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves C21ORF55 33
  • 67.39 (n)
DNAJC28 34
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJC28 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc28 33
  • 63.51 (n)
zebrafish
(Danio rerio)
Actinopterygii dnajc28 33 34
  • 55.04 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009787 33
  • 50.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG43322 33 34
  • 49.01 (n)
Species where no ortholog for DNAJC28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAJC28 Gene

ENSEMBL:
Gene Tree for DNAJC28 (if available)
TreeFam:
Gene Tree for DNAJC28 (if available)

Paralogs for DNAJC28 Gene

No data available for Paralogs for DNAJC28 Gene

Variants for DNAJC28 Gene

Sequence variations from dbSNP and Humsavar for DNAJC28 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs147358478 Uncertain significance 33,488,892(+) ATATT(A/C/G)CATCA reference, stop-gained
rs1000974058 -- 33,490,077(+) GGTGA(A/G)CCACT intron-variant
rs1001028126 -- 33,489,742(+) GCCTC(A/G)GCCTC intron-variant
rs1001424873 -- 33,487,771(+) AACCC(A/G)GGAGG downstream-variant-500B
rs1002206205 -- 33,489,492(+) AGCAA(G/T)AAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC28 Gene

Variant ID Type Subtype PubMed ID
nsv191 CNV insertion 15895083
nsv3497 CNV insertion 18451855
nsv509795 CNV insertion 20534489
nsv524420 CNV loss 19592680

Variation tolerance for DNAJC28 Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.97; 79.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJC28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC28 Gene

Disorders for DNAJC28 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DNAJC28 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 4, autosomal dominant or recessive
  • retinitis pigmentosa 4
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DNAJC28

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJC28
genes like me logo Genes that share disorders with DNAJC28: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNAJC28 Gene

Publications for DNAJC28 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis. (PMID: 12036298) Gardiner K … Davisson M (Genomics 2002) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld CA … Koellinger PD (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 60

Products for DNAJC28 Gene

Sources for DNAJC28 Gene

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