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Aliases for DNAJC28 Gene

Aliases for DNAJC28 Gene

  • DnaJ (Hsp40) Homolog, Subfamily C, Member 28 2 3
  • C21orf55 3 4
  • C21orf78 3 4
  • Chromosome 21 Open Reading Frame 55 2
  • DnaJ Homolog Subfamily C Member 28 3
  • Orf28 2

External Ids for DNAJC28 Gene

Previous HGNC Symbols for DNAJC28 Gene

  • C21orf55

Previous GeneCards Identifiers for DNAJC28 Gene

  • GC21M033782
  • GC21M034860
  • GC21M020338

Summaries for DNAJC28 Gene

GeneCards Summary for DNAJC28 Gene

DNAJC28 (DnaJ (Hsp40) Homolog, Subfamily C, Member 28) is a Protein Coding gene. Diseases associated with DNAJC28 include chickenpox.

UniProtKB/Swiss-Prot for DNAJC28 Gene

  • May have a role in protein folding or as a chaperone

Gene Wiki entry for DNAJC28 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC28 Gene

Genomics for DNAJC28 Gene

Regulatory Elements for DNAJC28 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DNAJC28 Gene

33,485,530 bp from pter
33,491,723 bp from pter
6,194 bases
Minus strand

Genomic View for DNAJC28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJC28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC28 Gene

Proteins for DNAJC28 Gene

  • Protein details for DNAJC28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily C member 28
    Protein Accession:
    Secondary Accessions:
    • D3DSF2

    Protein attributes for DNAJC28 Gene

    388 amino acids
    Molecular mass:
    45806 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DNAJC28 Gene

Proteomics data for DNAJC28 Gene at MOPED

Post-translational modifications for DNAJC28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJC28 Gene

Antibody Products

No data available for DME Specific Peptides for DNAJC28 Gene

Domains for DNAJC28 Gene

Gene Families for DNAJC28 Gene

Protein Domains for DNAJC28 Gene

Suggested Antigen Peptide Sequences for DNAJC28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 J domain.
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJC28: view

Function for DNAJC28 Gene

Molecular function for DNAJC28 Gene

UniProtKB/Swiss-Prot Function:
May have a role in protein folding or as a chaperone

Gene Ontology (GO) - Molecular Function for DNAJC28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24407287
genes like me logo Genes that share ontologies with DNAJC28: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJC28

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DNAJC28 Gene

Localization for DNAJC28 Gene

Subcellular locations from

Jensen Localization Image for DNAJC28 Gene COMPARTMENTS Subcellular localization image for DNAJC28 gene
Compartment Confidence
golgi apparatus 3
mitochondrion 3
nucleus 3
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DNAJC28 Gene

Pathways for DNAJC28 Gene

SuperPathways for DNAJC28 Gene

No Data Available

Interacting Proteins for DNAJC28 Gene

Selected Interacting proteins: Q9NX36-DJC28_HUMAN for DNAJC28 Gene via I2D MINT

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for DNAJC28 Gene


No data available for Pathways by source for DNAJC28 Gene

Drugs for DNAJC28 Gene

(2) Drugbank Compounds for DNAJC28 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • Aciclovir
59277-89-3 2022 Target inhibitor approved
  • 2-(2-(2-amino-9H-Purin-9-yl)ethyl)-1,3-propanediol diacetate
104227-87-4 3324 Target inhibitor approved
genes like me logo Genes that share compounds with DNAJC28: view

Transcripts for DNAJC28 Gene

Unigene Clusters for DNAJC28 Gene

DnaJ (Hsp40) homolog, subfamily C, member 28:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJC28

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC28 Gene

No ASD Table

Relevant External Links for DNAJC28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJC28 Gene

mRNA expression in normal human tissues for DNAJC28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAJC28 Gene

This gene is overexpressed in Testis (4.1).

Protein differential expression in normal tissues for DNAJC28 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DNAJC28 Gene

SOURCE GeneReport for Unigene cluster for DNAJC28 Gene Hs.458308

mRNA Expression by UniProt/SwissProt for DNAJC28 Gene

Tissue specificity: Expressed in the fetal and adult brain, testis, uterus, spleen and liver
genes like me logo Genes that share expressions with DNAJC28: view

Expression partners for DNAJC28 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for DNAJC28 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAJC28 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DNAJC28 35
  • 88.3 (n)
  • 83.11 (a)
DNAJC28 36
  • 82 (a)
(Canis familiaris)
Mammalia DNAJC28 35
  • 87.88 (n)
  • 83.9 (a)
-- 36
  • 82 (a)
-- 36
  • 82 (a)
(Mus musculus)
Mammalia Dnajc28 35
  • 78.57 (n)
  • 74.54 (a)
Dnajc28 16
Dnajc28 36
  • 69 (a)
(Pan troglodytes)
Mammalia DNAJC28 35
  • 99.48 (n)
  • 98.97 (a)
DNAJC28 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Dnajc28 35
  • 78.39 (n)
  • 75.07 (a)
(Monodelphis domestica)
Mammalia DNAJC28 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia DNAJC28 36
  • 68 (a)
(Gallus gallus)
Aves C21ORF55 35
  • 67.39 (n)
  • 60.49 (a)
DNAJC28 36
  • 57 (a)
(Anolis carolinensis)
Reptilia DNAJC28 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc28 35
  • 63.51 (n)
  • 60.06 (a)
(Danio rerio)
Actinopterygii dnajc28 35
  • 55.04 (n)
  • 49.59 (a)
dnajc28 36
  • 47 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009787 35
  • 50.61 (n)
  • 42.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43322 35
  • 49.01 (n)
  • 41.75 (a)
CG43322 36
  • 34 (a)
Species with no ortholog for DNAJC28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAJC28 Gene

Gene Tree for DNAJC28 (if available)
Gene Tree for DNAJC28 (if available)

Paralogs for DNAJC28 Gene

No data available for Paralogs for DNAJC28 Gene

Variants for DNAJC28 Gene

Sequence variations from dbSNP and Humsavar for DNAJC28 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs3761346 -- 33,491,682(+) CAGGG(C/G)ACCTC utr-variant-5-prime, upstream-variant-2KB
rs3761347 -- 33,491,977(+) AGGAG(C/T)CACCT upstream-variant-2KB
rs4816458 -- 33,487,794(+) tgagc(C/T)gagat downstream-variant-500B
rs4817575 -- 33,487,878(+) TAGCC(A/G)GGTAT downstream-variant-500B
rs4817576 -- 33,492,118(+) TGAGC(A/G)TTTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DNAJC28 Gene

Variant ID Type Subtype PubMed ID
nsv913724 CNV Loss 21882294
nsv3497 CNV Insertion 18451855
nsv524420 CNV Loss 19592680
nsv509795 CNV Insertion 20534489
nsv191 CNV Insertion 15895083

Relevant External Links for DNAJC28 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC28 Gene

Disorders for DNAJC28 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for DNAJC28 Gene in MalaCards »

(1) Disease for DNAJC28 Gene

(2) University of Copenhagen DISEASES for DNAJC28 Gene

genes like me logo Genes that share disorders with DNAJC28: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for DNAJC28 Gene

Publications for DNAJC28 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis. (PMID: 12036298) Gardiner K. … Davisson M. (Genomics 2002) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3
  5. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3

Products for DNAJC28 Gene

Sources for DNAJC28 Gene

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