Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DNAJC27 Gene

Aliases for DNAJC27 Gene

  • DnaJ (Hsp40) Homolog, Subfamily C, Member 27 2 3
  • RBJ 3 4 6
  • Rab And DnaJ Domain-Containing Protein 3 4
  • RabJS 3 4
  • DnaJ Homolog Subfamily C Member 27 3
  • Rab And DnaJ Domain Containing 2
  • Ras-Associated Protein Rap1 3

External Ids for DNAJC27 Gene

Previous Symbols for DNAJC27 Gene

  • RBJ

Summaries for DNAJC27 Gene

GeneCards Summary for DNAJC27 Gene

DNAJC27 (DnaJ (Hsp40) Homolog, Subfamily C, Member 27) is a Protein Coding gene. GO annotations related to this gene include GTP binding.

UniProtKB/Swiss-Prot for DNAJC27 Gene

  • GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC27 Gene

Genomics for DNAJC27 Gene

Genomic Location for DNAJC27 Gene

Start:
24,943,636 bp from pter
End:
24,972,094 bp from pter
Size:
28,459 bases
Orientation:
Minus strand

Genomic View for DNAJC27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJC27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC27 Gene

Regulatory Elements for DNAJC27 Gene

Proteins for DNAJC27 Gene

  • Protein details for DNAJC27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZQ0-DJC27_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 27
    Protein Accession:
    Q9NZQ0
    Secondary Accessions:
    • Q5JV88
    • Q86Y24

    Protein attributes for DNAJC27 Gene

    Size:
    273 amino acids
    Molecular mass:
    30855 Da
    Quaternary structure:
    • Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms).
    Miscellaneous:
    • DNAJC27/RBJ knockdown in several colorectal cancer cell lines is correlated to inhibition of MEK/ERK activation, cell proliferation, colony formation and in vivo tumor growth.

    Three dimensional structures from OCA and Proteopedia for DNAJC27 Gene

    Alternative splice isoforms for DNAJC27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJC27 Gene

Proteomics data for DNAJC27 Gene at MOPED

Post-translational modifications for DNAJC27 Gene

No Post-translational modifications

Other Protein References for DNAJC27 Gene

No data available for DME Specific Peptides for DNAJC27 Gene

Domains for DNAJC27 Gene

Gene Families for DNAJC27 Gene

HGNC:
  • DNAJ :Heat shock proteins / DNAJ (HSP40)

Protein Domains for DNAJC27 Gene

UniProtKB/Swiss-Prot:

DJC27_HUMAN
Domain:
  • Contains 1 J domain.:
    • Q9NZQ0
Family:
  • Belongs to the small GTPase superfamily. Rab family.:
    • Q9NZQ0
genes like me logo Genes that share domains with DNAJC27: view

Function for DNAJC27 Gene

Molecular function for DNAJC27 Gene

UniProtKB/Swiss-Prot Function: GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.

Gene Ontology (GO) - Molecular Function for DNAJC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with DNAJC27: view

Phenotypes for DNAJC27 Gene

GenomeRNAi human phenotypes for DNAJC27:
genes like me logo Genes that share phenotypes with DNAJC27: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DNAJC27 Gene

Localization for DNAJC27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC27 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJC27 Gene COMPARTMENTS Subcellular localization image for DNAJC27 gene
Compartment Confidence
cytosol 3
mitochondrion 2
extracellular 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DNAJC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IEA --
GO:0012505 NOT endomembrane system IBA --
genes like me logo Genes that share ontologies with DNAJC27: view

Pathways for DNAJC27 Gene

SuperPathways for DNAJC27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction --
genes like me logo Genes that share ontologies with DNAJC27: view

No data available for Pathways by source for DNAJC27 Gene

Transcripts for DNAJC27 Gene

Unigene Clusters for DNAJC27 Gene

DnaJ (Hsp40) homolog, subfamily C, member 27:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC27 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: -
SP2: - -
SP3:

Relevant External Links for DNAJC27 Gene

GeneLoc Exon Structure for
DNAJC27
ECgene alternative splicing isoforms for
DNAJC27

Expression for DNAJC27 Gene

mRNA expression in normal human tissues for DNAJC27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DNAJC27 Gene

SOURCE GeneReport for Unigene cluster for DNAJC27 Gene Hs.434993

mRNA Expression by UniProt/SwissProt for DNAJC27 Gene

Q9NZQ0-DJC27_HUMAN
Tissue specificity: Overexpressed in gastrointestinal cancers; expression correlates with later tumor-node-metastasis stages of colorectal cancers.
genes like me logo Genes that share expressions with DNAJC27: view

Orthologs for DNAJC27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DNAJC27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC27 36
  • 99.63 (n)
  • 100 (a)
DNAJC27 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAJC27 36
  • 93.53 (n)
  • 95.6 (a)
DNAJC27 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJC27 36
  • 93.04 (n)
  • 96.7 (a)
DNAJC27 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajc27 36
  • 89.87 (n)
  • 93.41 (a)
Dnajc27 16
Dnajc27 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNAJC27 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC27 37
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajc27 36
  • 89.26 (n)
  • 93.04 (a)
chicken
(Gallus gallus)
Aves DNAJC27 36
  • 79.98 (n)
  • 91.58 (a)
DNAJC27 37
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJC27 37
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia loc51277-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486435 36
  • 77.17 (n)
  • 85.24 (a)
zebrafish
(Danio rerio)
Actinopterygii dnajc27 36
  • 73.26 (n)
  • 84.25 (a)
dnajc27 37
  • 84 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14953 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
OneToMany
CSA.1471 37
  • 66 (a)
OneToMany
Species with no ortholog for DNAJC27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAJC27 Gene

ENSEMBL:
Gene Tree for DNAJC27 (if available)
TreeFam:
Gene Tree for DNAJC27 (if available)

Paralogs for DNAJC27 Gene

Selected SIMAP similar genes for DNAJC27 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DNAJC27: view

No data available for Paralogs for DNAJC27 Gene

Variants for DNAJC27 Gene

Sequence variations from dbSNP and Humsavar for DNAJC27 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs754536 -- 24,953,331(+) CTTGA(C/T)GTCTG intron-variant
rs754537 -- 24,953,408(+) GTCTT(A/T)ATATT intron-variant
rs955855 -- 24,949,440(-) TCTCC(C/T)GCTAC intron-variant
rs955856 -- 24,949,364(-) CCCTC(C/T)CTGGG intron-variant
rs1172293 -- 24,945,051(+) AATAA(A/G)GTTGA utr-variant-3-prime, nc-transcript-variant

Relevant External Links for DNAJC27 Gene

HapMap Linkage Disequilibrium report
DNAJC27

No data available for Structural Variations from Database of Genomic Variants (DGV) for DNAJC27 Gene

Disorders for DNAJC27 Gene

Relevant External Links for DNAJC27

Genetic Association Database (GAD)
DNAJC27
Human Genome Epidemiology (HuGE) Navigator
DNAJC27
genes like me logo Genes that share disorders with DNAJC27: view

No data available for UniProtKB/Swiss-Prot for DNAJC27 Gene

Publications for DNAJC27 Gene

  1. RJLs: a new family of Ras-related GTP-binding proteins. (PMID: 14980719) Nepomuceno-Silva J.L. … Lopes U.G. (Gene 2004) 2 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  3. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3 49
  4. Small GTPase RBJ mediates nuclear entrapment of MEK1/MEK2 in tumor progression. (PMID: 24746703) Chen T. … Cao X. (Cancer Cell 2014) 3 4
  5. Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. (PMID: 24861553) Wen W. … Tanaka T. (Hum. Mol. Genet. 2014) 3

Products for DNAJC27 Gene

Sources for DNAJC27 Gene

Back to Top

Content