DNAJC27 Gene
protein-coding GIFtS: 47
GCID: GC02M025166
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DnaJ (Hsp40) homolog, subfamily C, member 27(Previous name: rab and DnaJ domain containing )
(Previous symbol: RBJ)
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Aliases
for DNAJC27 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DnaJ (Hsp40) Homolog, Subfamily C, Member 271 2 | | Rab And DnaJ Domain Containing1 | | RBJ1 2 3 5 | | DnaJ Homolog Subfamily C Member 272 | | RabJS1 2 | | Ras-Associated Protein Rap12 | | Rab And DnaJ Domain-Containing Protein2 3 | | RABJS3 |
Export aliases for DNAJC27 gene to outside databasesPrevious GC identifers: GC02M025021 GC02M024904 |
Summaries
for DNAJC27 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for DNAJC27 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DNAJC27 gene promoter:
NF-1 NF-1/L Sox5 E47 PPAR-gamma1 Pax-3 Hand1 ZID PPAR-gamma2 Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for DNAJC27
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJC27 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p23.3 Ensembl cytogenetic band: 2p23.3 HGNC cytogenetic band: 2p23.3DNAJC27 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M025166: view genomic region
(about GC identifiers)
Start:
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25,166,505 bp from pter |
End:
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25,194,963 bp from pter |
Size:
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28,459 bases |
Orientation:
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minus strand |
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Proteins
for DNAJC27 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DJC27_HUMAN, Q9NZQ0 (See
protein sequence)Recommended Name: DnaJ homolog subfamily C member 27 Size: 273 amino acids; 30855 Da
Miscellaneous: May lack GTPase activity
1 PDB 3D structure from  and Proteopedia  for DNAJC27:2YS8 (3D)
Secondary accessions: Q5JV88 Q86Y24Alternative splicing: 3 isoforms: Q9NZQ0-1 Q9NZQ0-2 Q9NZQ0-3 Explore the universe of human proteins at neXtProt for DNAJC27: NX_Q9NZQ0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NZQ0
DNAJC27 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001185488.1 NP_057628.1
ENSEMBL proteins: ENSP00000264711 ENSP00000370187 ENSP00000440086
Human Recombinant Protein Products for DNAJC27:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
DNAJC27 for ontologies About GeneDecksing
DNAJC27 Antibody Products:
Assay Products for DNAJC27: |
Protein
Domains /
Families
for DNAJC27 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DNAJC27 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NZQ0ProtoNet protein and cluster: Q9NZQ0 1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: DJC27_HUMAN, Q9NZQ0Similarity: Belongs to the small GTPase superfamily. Rab familySimilarity: Contains 1 J domain |
Function
for DNAJC27 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
DNAJC27 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for DNAJC27:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC27 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC27
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for DNAJC27 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC27 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC27 |
|
Pathways & Interactions
for DNAJC27 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNAJC27
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for DNAJC27 (ENSP000002647114) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006457 | protein folding |
IEA | -- | | GO:0007264 | small GTPase mediated signal transduction |
IEA | -- |
DNAJC27 for ontologies About GeneDecksing
|
Drugs & Compounds
for DNAJC27 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DNAJC27
Search CenterWatch for drugs/clinical trials and news about DNAJC27 / DJC27
|
Transcripts
for DNAJC27 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DNAJC27 gene (2 alternative transcripts): NM_001198559.1 NM_016544.2 Unigene Cluster for DNAJC27: DnaJ (Hsp40) homolog, subfamily C, member 27 Hs.434993 [show with all ESTs]Unigene Representative Sequence: NM_0165447 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000264711(uc010ykn.1 uc002rft.2 uc010eyg.2 uc002rfu.2)
ENST00000380809 ENST00000494239 ENST00000468467 ENST00000468750 ENST00000492985
ENST00000534855
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC27 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC27
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): DNAJC27 (NM_016544) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DNAJC27 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC27 |
Additional cDNA sequence: AF178983.1 AK294726.1 AL117490.1 AY094594.1 BC034049.1 7 DOTS entries: DT.311049 DT.121033216 DT.107945 DT.92416452 DT.40202058 DT.204136 DT.99997100 24/117 AceView cDNA sequences (see all 117): BU674253 BF445877 AA907791 AA370556 AL137731 BQ269731 AI669200 AW663500 BU674239 N94806 BI711075 BE672439 BP369591 NM_016544 AI051705 AW772410 BQ185282 AA971407 BX107190 BM715421 AW628006 BE466713 AI243060 AW152177
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC27 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c |
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| SP1: | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DNAJC27
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Expression
for DNAJC27 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DNAJC27 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATAAGTGAG
About this image
See DNAJC27 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DNAJC27
SOURCE GeneReport for Unigene cluster: Hs.434993
SABiosciences Custom PCR Arrays for DNAJC27
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNAJC27
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DNAJC27 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAJC27 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAJC27 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC27 |
Orthologs
for DNAJC27 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for DNAJC27 gene from 5/19 species (see all 19) About this table
ENSEMBL Gene Tree for DNAJC27 (if available)
TreeFam Gene Tree for DNAJC27 (if available) |
Paralogs
for DNAJC27 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DNAJC27 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DNAJC27 (25166505 - 25194963 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DNAJC27: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNAJC27 |
|
Disorders
/ Diseases
for DNAJC27 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DNAJC27 for disorders About GeneDecksing
OMIM gene information: 613527
OMIM disorders: --
1  disease for DNAJC27: About MalaCardsovarian hyperstimulation syndrome
Human Genome Epidemiology (HuGE) Navigator: DNAJC27 (1 document)
Export disorders for DNAJC27 gene to outside databases
|
Publications
for DNAJC27 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DNAJC27 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with DNAJC27) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- RJLs: a new family of Ras-related GTP-binding proteins. (PubMed id 14980719)1, 2, 3 Nepomuceno-Silva J.L....Lopes U.G. (2004)
- Meta-analysis identifies common variants associated wi th body mass index in east Asians. (PubMed id 22344219)1 Wen W....Shu X.O. (2012)
- A genome-wide meta-analysis of six type 1 diabetes coh orts identifies multiple associated loci. (PubMed id 21980299)1 Bradfield J.P....Hakonarson H. (2011)
- Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1 Speliotes E.K....Loos R.J. (2010)
- Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1 Lango Allen H....Hirschhorn J.N. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1 Gudbjartsson D.F....Stefansson K. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for DNAJC27 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DNAJC27 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DNAJC27 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DNAJC27 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DNAJC27 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DNAJC27 gene:
Search GeneIP for patents involving DNAJC27
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DNAJC27 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DNAJC27 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNAJC27 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNAJC27 | | | OriGene Protein Over-expression Lysate for DNAJC27 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DNAJC27 | | OriGene 3'-UTR Clone for DNAJC27 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC27 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC27 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DNAJC27 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DNAJC27 | | OriGene Custom Protein Services for DNAJC27 | | | OriGene Custom Immunoassay Development | | |
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 | | | DNAJC27 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC27 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for DNAJC27 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC27 |
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