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Aliases for DNAJC27 Gene

Aliases for DNAJC27 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C27 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 27 2 3
  • Rab And DnaJ Domain-Containing Protein 3 4
  • RabJS 3 4
  • RBJ 3 4
  • DnaJ Homolog Subfamily C Member 27 3
  • Rab And DnaJ Domain Containing 2
  • Ras-Associated Protein Rap1 3

External Ids for DNAJC27 Gene

Previous HGNC Symbols for DNAJC27 Gene

  • RBJ

Previous GeneCards Identifiers for DNAJC27 Gene

  • GC02M025021
  • GC02M025166

Summaries for DNAJC27 Gene

GeneCards Summary for DNAJC27 Gene

DNAJC27 (DnaJ Heat Shock Protein Family (Hsp40) Member C27) is a Protein Coding gene. GO annotations related to this gene include GTP binding and GTPase activity.

UniProtKB/Swiss-Prot for DNAJC27 Gene

  • GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC27 Gene

Genomics for DNAJC27 Gene

Regulatory Elements for DNAJC27 Gene

Enhancers for DNAJC27 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G025672 1 ENCODE 20.3 -701.3 -701298 2.4 FOXA2 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF48 ELK1 ZNF143 DNAJC27 DTNB GC02P025633
GH02G024885 1.2 FANTOM5 Ensembl ENCODE 12.4 +85.7 85694 2.8 SCRT1 PKNOX1 SMARCA4 POLR2A BHLHE40 NR2F1 FOS CHD2 ADCY3 DNAJC27 DNAJC27-AS1 ENSG00000202479 RPS13P5 PTRHD1 LOC105377626
GH02G024827 1.1 Ensembl ENCODE 10.2 +144.2 144238 1.9 ELF3 HDGF PTBP1 AGO1 ARID4B NFXL1 ZNF48 RAD21 ZNF143 CREM NCOA1 ADCY3 PTRHD1 CENPO ENSG00000202479 RPS13P5 DNAJC27-AS1 DNAJC27 ITSN2 ENSG00000242628
GH02G025886 0.9 ENCODE 11.1 -914.0 -914033 0.2 ELF3 FOXA2 MLX ZFP64 SIN3A ZNF48 ZSCAN9 FOS KLF11 SP5 DNAJC27 NDUFB4P4 ASXL2
GH02G024970 1.4 ENCODE dbSUPER 7.1 -0.1 -142 3.6 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC GLIS1 RCOR2 ADCY3 EFR3B LINC01381 POMC DNAJC27 PTRHD1 GC02M025008 ENSG00000207069
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DNAJC27 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJC27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000114106 94 2401 CREB3L1 AGO1 ZFP64 DMAP1 YY1 SP3 NFYC GLIS1 RCOR2 NBN

Genomic Location for DNAJC27 Gene

Chromosome:
2
Start:
24,943,636 bp from pter
End:
24,972,094 bp from pter
Size:
28,459 bases
Orientation:
Minus strand

Genomic View for DNAJC27 Gene

Genes around DNAJC27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC27 Gene

Proteins for DNAJC27 Gene

  • Protein details for DNAJC27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZQ0-DJC27_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 27
    Protein Accession:
    Q9NZQ0
    Secondary Accessions:
    • Q5JV88
    • Q86Y24

    Protein attributes for DNAJC27 Gene

    Size:
    273 amino acids
    Molecular mass:
    30855 Da
    Quaternary structure:
    • Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms).
    Miscellaneous:
    • DNAJC27/RBJ knockdown in several colorectal cancer cell lines is correlated to inhibition of MEK/ERK activation, cell proliferation, colony formation and in vivo tumor growth.

    Three dimensional structures from OCA and Proteopedia for DNAJC27 Gene

    Alternative splice isoforms for DNAJC27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJC27 Gene

Post-translational modifications for DNAJC27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJC27 Gene

No data available for DME Specific Peptides for DNAJC27 Gene

Domains & Families for DNAJC27 Gene

Gene Families for DNAJC27 Gene

Suggested Antigen Peptide Sequences for DNAJC27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZQ0

UniProtKB/Swiss-Prot:

DJC27_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with DNAJC27: view

Function for DNAJC27 Gene

Molecular function for DNAJC27 Gene

UniProtKB/Swiss-Prot Function:
GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.

Gene Ontology (GO) - Molecular Function for DNAJC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with DNAJC27: view
genes like me logo Genes that share phenotypes with DNAJC27: view

Animal Models for DNAJC27 Gene

MGI Knock Outs for DNAJC27:

Animal Model Products

  • Taconic Biosciences Mouse Models for DNAJC27

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DNAJC27 Gene

Localization for DNAJC27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC27 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJC27 gene
Compartment Confidence
nucleus 4
cytosol 4
mitochondrion 2
plasma membrane 1
extracellular 1

Gene Ontology (GO) - Cellular Components for DNAJC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with DNAJC27: view

Pathways & Interactions for DNAJC27 Gene

SuperPathways for DNAJC27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0043410 positive regulation of MAPK cascade IEA --
GO:0070374 positive regulation of ERK1 and ERK2 cascade IEA --
GO:0071701 regulation of MAPK export from nucleus IEA --
genes like me logo Genes that share ontologies with DNAJC27: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJC27 Gene

Transcripts for DNAJC27 Gene

Unigene Clusters for DNAJC27 Gene

DnaJ (Hsp40) homolog, subfamily C, member 27:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC27 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: -
SP2: - -
SP3:

Relevant External Links for DNAJC27 Gene

GeneLoc Exon Structure for
DNAJC27
ECgene alternative splicing isoforms for
DNAJC27

Expression for DNAJC27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJC27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJC27 Gene

This gene is overexpressed in Platelet (31.9), Heart (20.4), and Bone marrow mesenchymal stem cell (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DNAJC27 Gene



Protein tissue co-expression partners for DNAJC27 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJC27 Gene:

DNAJC27

SOURCE GeneReport for Unigene cluster for DNAJC27 Gene:

Hs.434993

mRNA Expression by UniProt/SwissProt for DNAJC27 Gene:

Q9NZQ0-DJC27_HUMAN
Tissue specificity: Overexpressed in gastrointestinal cancers; expression correlates with later tumor-node-metastasis stages of colorectal cancers.

Evidence on tissue expression from TISSUES for DNAJC27 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with DNAJC27: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJC27 Gene

Orthologs for DNAJC27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DNAJC27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC27 34 35
  • 99.63 (n)
cow
(Bos Taurus)
Mammalia DNAJC27 34 35
  • 93.53 (n)
dog
(Canis familiaris)
Mammalia DNAJC27 34 35
  • 93.04 (n)
oppossum
(Monodelphis domestica)
Mammalia DNAJC27 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajc27 34 16 35
  • 89.87 (n)
rat
(Rattus norvegicus)
Mammalia Dnajc27 34
  • 89.26 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC27 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJC27 34 35
  • 79.98 (n)
lizard
(Anolis carolinensis)
Reptilia DNAJC27 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486435 34
  • 77.17 (n)
African clawed frog
(Xenopus laevis)
Amphibia loc51277-prov 34
zebrafish
(Danio rerio)
Actinopterygii dnajc27 34 35
  • 73.26 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1471 35
  • 66 (a)
OneToMany
-- 35
  • 30 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14953 34
Species where no ortholog for DNAJC27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAJC27 Gene

ENSEMBL:
Gene Tree for DNAJC27 (if available)
TreeFam:
Gene Tree for DNAJC27 (if available)

Paralogs for DNAJC27 Gene

(8) SIMAP similar genes for DNAJC27 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DNAJC27: view

No data available for Paralogs for DNAJC27 Gene

Variants for DNAJC27 Gene

Sequence variations from dbSNP and Humsavar for DNAJC27 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000054115 -- 24,958,892(+) TTATA(C/T)GTTCT intron-variant
rs1000098275 -- 24,966,471(+) TTTTT(C/G)TTTTT intron-variant
rs1000106106 -- 24,948,887(+) TGGTG(C/G)TTTAC intron-variant
rs1000118260 -- 24,965,700(+) TCTTG(A/T)GTTTT intron-variant
rs1000185514 -- 24,952,281(+) AAATT(C/T)ACCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC27 Gene

Variant ID Type Subtype PubMed ID
nsv1004529 CNV loss 25217958
nsv1008732 CNV loss 25217958
nsv997725 CNV gain 25217958

Variation tolerance for DNAJC27 Gene

Residual Variation Intolerance Score: 48.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJC27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC27 Gene

Disorders for DNAJC27 Gene

Relevant External Links for DNAJC27

Genetic Association Database (GAD)
DNAJC27
Human Genome Epidemiology (HuGE) Navigator
DNAJC27
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJC27

No disorders were found for DNAJC27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC27 Gene

Publications for DNAJC27 Gene

  1. RJLs: a new family of Ras-related GTP-binding proteins. (PMID: 14980719) Nepomuceno-Silva J.L. … Lopes U.G. (Gene 2004) 2 3 4 64
  2. Small GTPase RBJ mediates nuclear entrapment of MEK1/MEK2 in tumor progression. (PMID: 24746703) Chen T. … Cao X. (Cancer Cell 2014) 3 4 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3 46 64
  5. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3 64

Products for DNAJC27 Gene

Sources for DNAJC27 Gene

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