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DNAJC25-GNG10 Gene

protein-coding   GIFtS: 25
GCID: GC09P114394

DNAJC25-GNG10 Readthrough

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DNAJC25-GNG10 Readthrough1 2
DNAJC25-GNG10 Protein2
DNAJC25-GNG10 Readthrough Transcript2

External Ids:    HGNC: 375011   Entrez Gene: 5528912   Ensembl: ENSG000002441157   

Export aliases for DNAJC25-GNG10 gene to outside databases

Previous GC identifers: GC09P113445 GC09P113447 GC09P083993


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNAJC25-GNG10 Gene:
This gene represents naturally-occurring mRNAs that are co-transcribed products of the neighboring DNAJC25 and
GNG10 genes. These transcripts include the first exon of DNAJC25 and the last two exons of GNG10, resulting in a
protein that combines the N-terminus of DNAJC25 and the C-terminus of GNG10. (provided by RefSeq, Dec 2008)

GeneCards Summary for DNAJC25-GNG10 Gene:
DNAJC25-GNG10 (DNAJC25-GNG10 readthrough) is a protein-coding gene. An important paralog of this gene is DNAJC25.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the DNAJC25-GNG10 gene promoter:
         ER-alpha   HFH-3   Sox5   p300   C/EBPalpha   FOXI1   CREB   CHOP-10   deltaCREB   HSF2   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAJC25-GNG10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31.3   Ensembl cytogenetic band:  9q31.3   HGNC cytogenetic band: 9q31.3

DNAJC25-GNG10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJC25-GNG10 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P114394:  view genomic region     (about GC identifiers)

Start:
114,393,632 bp from pter      End:
114,432,526 bp from pter
Size:
38,895 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB: --
Explore proteomics data for DNAJC25-GNG10 at MOPED


See DNAJC25-GNG10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_004116.2  
ENSEMBL proteins: 
 ENSP00000363412  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004871signal transducer activity ----
     
Find genes that share ontologies with DNAJC25-GNG10           About GenesLikeMe


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular2
cytosol1
endoplasmic reticulum1
mitochondrion1
nucleus1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005834heterotrimeric G-protein complex ----

Find genes that share ontologies with DNAJC25-GNG10           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for DNAJC25-GNG10 About   (see all 18)  
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1ADP signalling through P2Y purinoceptor 12
G-protein beta-gamma signalling0.90
ADP signalling through P2Y purinoceptor 120.74
G beta-gamma signalling through PI3Kgamma0.90
G-protein activation0.74
Signal amplification0.79
Thrombin signalling through proteinase activated receptors (PARs)0.69
ADP signalling through P2Y purinoceptor 10.79
Activation of Kainate Receptors upon glutamate binding0.68
2Inwardly rectifying K+ channels
Inwardly rectifying K+ channels0.82
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits0.82
G protein gated Potassium channels0.82
Activation of G protein gated Potassium channels0.82
3Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90
4beta-catenin independent WNT signaling
beta-catenin independent WNT signaling0.79
Ca2+ pathway0.43
Signaling by Wnt0.79
5Integration of energy metabolism
Integration of energy metabolism0.75
Regulation of Insulin Secretion by Glucagon-like Peptide-10.56
Regulation of Insulin Secretion0.75



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STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for DNAJC25-GNG10 (ENSP000003634124) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
CLPBENSP000002940534STRING: ENSP00000294053
TUFMENSP000003224394STRING: ENSP00000322439
GRPEL1ENSP000002649544STRING: ENSP00000264954
GRPEL2ENSP000003295584STRING: ENSP00000329558
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DNAJC25-GNG10



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for DNAJC25-GNG10 gene: 
NM_004125.3  

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000374294(uc004bfn.3)
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DNAJC25-GNG10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
DNAJC25-GNG10 Expression
About this image

DNAJC25-GNG10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DNAJC25-GNG10 Protein Expression
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for DNAJC25-GNG10 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
22(a)
1 → many
Z(66220482-66227617)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
20(a)
1 → many
GL343476.1(483464-497588)
zebrafish
(Danio rerio)
Actinopterygii dnajc256
DnaJ (Hsp40) homolog, subfamily C , member 25
20(a)
1 → many
5(72980734-72989853) ENSDARG00000067613
fruit fly
(Drosophila melanogaster)
Insecta CG78726
--
17(a)
1 → many
X(15472203-15473890)
worm
(Caenorhabditis elegans)
Secernentea dnj-26
C47A4.16
Protein C47A4.1 (C47A4.1) mRNA, complete cds
13(a)
1(a)
many ↔ many
many ↔ many
IV(11312473-11313976) WBGene00001020
IV(13715906-13716379) WBGene00008122
        Species with no ortholog for DNAJC25-GNG10

ENSEMBL Gene Tree for DNAJC25-GNG10 (if available)
TreeFam Gene Tree for DNAJC25-GNG10 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for DNAJC25-GNG10 gene
DNAJC252  

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for DNAJC25-GNG10 (see all 109)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1917527151,2
--114417152(+) CCTAAA/CAACAT 1 -- int10--------
rs1835230041,2
--114417163(+) AAGTAC/TGTGAC 1 -- int10--------
rs1878626281,2
--114417200(+) GTCAGC/TACTCG 1 -- int10--------
rs1916086651,2
--114417213(+) TCTCAA/GAATTT 1 -- int10--------
rs172688091,2
C,F,H--114417231(+) CCTCTA/GTTAAC 1 -- int110Minor allele frequency- G:0.03NA NS 1324
rs727480871,2
C--114417241(+) CCTAGC/TGACGA 1 -- int10--------
rs109809951,2
C,F,A,H--114417248(+) ACGAAC/GTGTAA 1 -- int135Minor allele frequency- N:0.00EA NA NS WA CSA 3411
rs1123984201,2
C,F--114417347(+) TATTTC/TTTCCA 1 -- int12Minor allele frequency- T:0.09NA 122
rs785901551,2
C--114417419(+) CAGTC-/TTTTGGA 1 -- int10--------
rs2003203341,2
C--114417420(-) TCCAAA/GAGACT 1 -- int10--------

HapMap Linkage Disequilibrium report for DNAJC25-GNG10 (114393632 - 114432526 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for DNAJC25-GNG10:    About this table    
Variant IDTypeSubtypePubMed ID
nsv893725CNV Loss21882294
nsv893724CNV Gain21882294
nsv825041CNV Gain20364138
nsv466486CNV Gain19166990
nsv893726CNV Gain21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for DNAJC25-GNG10 gene integrated from 10 sources:
(articles sorted by number of sources associating them with DNAJC25-GNG10)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)
  2. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1 Humphray S.J.... Dunham I. (Nature 2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  6. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 552891 HGNC: 37501 Ensembl:ENSG00000244115 euGenes: HUgn552891 ECgene: DNAJC25-GNG10
H-InvDB: DNAJC25-GNG10

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for DNAJC25-GNG10 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for DNAJC25-GNG10 gene:
Search GeneIP for patents involving DNAJC25-GNG10

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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