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Aliases for DNAJC25 Gene

Aliases for DNAJC25 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C25 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C , Member 25 2 3
  • DnaJ Homolog Subfamily C Member 25 3
  • DnaJ-Like Protein 3
  • BA16L21.2.1 3

External Ids for DNAJC25 Gene

Previous GeneCards Identifiers for DNAJC25 Gene

  • GC09P113444
  • GC09P113446
  • GC09P114393
  • GC09P083992

Summaries for DNAJC25 Gene

GeneCards Summary for DNAJC25 Gene

DNAJC25 (DnaJ Heat Shock Protein Family (Hsp40) Member C25) is a Protein Coding gene. An important paralog of this gene is DNAJC25-GNG10.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC25 Gene

Genomics for DNAJC25 Gene

Regulatory Elements for DNAJC25 Gene

Enhancers for DNAJC25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F111630 1.1 ENCODE 9.9 +0.3 259 2.5 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 LRRC37A5P DNAJC25 DNAJC25-GNG10 GNG10
GH09F110990 0.8 FANTOM5 ENCODE 6.1 -640.4 -640425 1.2 SCRT2 ZNF623 ATF2 LPAR1 DNAJC25 ENSG00000207401
GH09F111626 1.3 FANTOM5 ENCODE 6 -3.9 -3856 1.8 HDGF ESRRA TFAP4 PKNOX1 ZNF384 CEBPG RAD21 POLR2A ZNF143 HNF4G PTGR1 DNAJC25 LRRC37A5P PIR58841
GH09F112027 1.2 FANTOM5 Ensembl ENCODE 5.7 +404.9 404912 16.8 HDGF PKNOX1 WRNIP1 NSD2 SIN3A YBX1 GATA2 ZNF207 FOS DEK RNU6-710P RNU6-1013P ENSG00000259953 DNAJC25 ENSG00000227531 LOC105376220
GH09F111942 1.2 Ensembl ENCODE 4.8 +313.1 313102 3.9 PKNOX1 MTA2 CBFB CEBPB BMI1 TBX21 EP300 RELA EED IKZF1 UGCG RNU6-710P RNU6-1013P GNG10 DNAJC25 MIR4668
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DNAJC25 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJC25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001311606 249 2800 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1

Genomic Location for DNAJC25 Gene

Chromosome:
9
Start:
111,631,352 bp from pter
End:
111,654,351 bp from pter
Size:
23,000 bases
Orientation:
Plus strand

Genomic View for DNAJC25 Gene

Genes around DNAJC25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC25 Gene

Proteins for DNAJC25 Gene

  • Protein details for DNAJC25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1X3-DJC25_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 25
    Protein Accession:
    Q9H1X3
    Secondary Accessions:
    • Q5QTD8
    • Q96BN9

    Protein attributes for DNAJC25 Gene

    Size:
    360 amino acids
    Molecular mass:
    42404 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DNAJC25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJC25 Gene

Post-translational modifications for DNAJC25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJC25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJC25 Gene

Domains & Families for DNAJC25 Gene

Gene Families for DNAJC25 Gene

Protein Domains for DNAJC25 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DNAJC25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H1X3

UniProtKB/Swiss-Prot:

DJC25_HUMAN :
  • Contains 1 J domain.
  • Belongs to the DNAJC25 family.
Domain:
  • Contains 1 J domain.
Family:
  • Belongs to the DNAJC25 family.
genes like me logo Genes that share domains with DNAJC25: view

Function for DNAJC25 Gene

genes like me logo Genes that share phenotypes with DNAJC25: view

Animal Model Products

miRNA for DNAJC25 Gene

miRTarBase miRNAs that target DNAJC25

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJC25 Gene

Localization for DNAJC25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC25 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for DNAJC25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DNAJC25: view

No data available for Subcellular locations from COMPARTMENTS for DNAJC25 Gene

Pathways & Interactions for DNAJC25 Gene

SuperPathways for DNAJC25 Gene

No Data Available

Interacting Proteins for DNAJC25 Gene

Gene Ontology (GO) - Biological Process for DNAJC25 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DNAJC25 Gene

Transcripts for DNAJC25 Gene

mRNA/cDNA for DNAJC25 Gene

(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC25 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: -
SP2: - -
SP3:
SP4: - - -
SP5:
SP6:
SP7: - - - - - - - -

Relevant External Links for DNAJC25 Gene

GeneLoc Exon Structure for
DNAJC25
ECgene alternative splicing isoforms for
DNAJC25

Expression for DNAJC25 Gene

mRNA expression in normal human tissues for DNAJC25 Gene

mRNA differential expression in normal tissues according to GTEx for DNAJC25 Gene

This gene is overexpressed in Liver (x4.2).

Protein differential expression in normal tissues from HIPED for DNAJC25 Gene

This gene is overexpressed in Adrenal (25.2), Bone (8.1), and Liver (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNAJC25 Gene



Protein tissue co-expression partners for DNAJC25 Gene

NURSA nuclear receptor signaling pathways regulating expression of DNAJC25 Gene:

DNAJC25
genes like me logo Genes that share expression patterns with DNAJC25: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DNAJC25 Gene

Orthologs for DNAJC25 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJC25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC25 34 35
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia DNAJC25 34 35
  • 92.32 (n)
cow
(Bos Taurus)
Mammalia DNAJC25 34 35
  • 89.79 (n)
mouse
(Mus musculus)
Mammalia Dnajc25 34 16 35
  • 87.86 (n)
rat
(Rattus norvegicus)
Mammalia Dnajc25 34
  • 86.4 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 77 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC25 35
  • 77 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 78 (a)
OneToMany
DNAJC25 34
  • 77.49 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 74 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc25 34
  • 70.36 (n)
zebrafish
(Danio rerio)
Actinopterygii dnajc25 34 35
  • 69.77 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7872 34 35
  • 59.39 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000831 34
  • 54.91 (n)
worm
(Caenorhabditis elegans)
Secernentea dnj-2 34 35
  • 50.38 (n)
C47A4.1 35
  • 34 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G61770 34
  • 46.62 (n)
rice
(Oryza sativa)
Liliopsida Os12g0258200 34
  • 47.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToMany
Species where no ortholog for DNAJC25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC25 Gene

ENSEMBL:
Gene Tree for DNAJC25 (if available)
TreeFam:
Gene Tree for DNAJC25 (if available)

Paralogs for DNAJC25 Gene

Paralogs for DNAJC25 Gene

(3) SIMAP similar genes for DNAJC25 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DNAJC25: view

Variants for DNAJC25 Gene

Sequence variations from dbSNP and Humsavar for DNAJC25 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10121084 -- 111,630,126(+) TATAT(A/G)TGTAA intron-variant, upstream-variant-2KB
rs1013923 -- 111,650,293(+) CCACA(C/G)AGACT intron-variant
rs1013925 -- 111,651,054(+) TTGAG(A/G)TCAGG intron-variant
rs10435862 -- 111,645,319(+) GTACA(A/G)TCTCG intron-variant
rs1051423 -- 111,654,018(+) CTCTC(G/T)TCACT intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DNAJC25 Gene

Variant ID Type Subtype PubMed ID
nsv615192 CNV loss 21841781
nsv825041 CNV gain 20364138

Variation tolerance for DNAJC25 Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.49; 71.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJC25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC25 Gene

Disorders for DNAJC25 Gene

Relevant External Links for DNAJC25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJC25

No disorders were found for DNAJC25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC25 Gene

Publications for DNAJC25 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for DNAJC25 Gene

Sources for DNAJC25 Gene

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