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DNAJC25 Gene

protein-coding   GIFtS: 40
GCID: GC09P114393

DnaJ (Hsp40) Homolog, Subfamily C , Member 25

  Search for DNAJC25
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DnaJ (Hsp40) Homolog, Subfamily C , Member 251 2
bA16L21.2.12
DnaJ Homolog Subfamily C Member 252
DnaJ-Like Protein2

External Ids:    HGNC: 341871   Entrez Gene: 5486452   Ensembl: ENSG000000597697   UniProtKB: Q9H1X33   

Export aliases for DNAJC25 gene to outside databases

Previous GC identifers: GC09P113444 GC09P113446 GC09P083992


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DNAJC25 Gene:
DNAJC25 (DnaJ (Hsp40) homolog, subfamily C , member 25) is a protein-coding gene. An important paralog of this gene is DNAJC25-GNG10.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the DNAJC25 gene promoter:
         ER-alpha   HFH-3   Sox5   p300   C/EBPalpha   FOXI1   CREB   CHOP-10   deltaCREB   HSF2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for DNAJC25

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAJC25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31.3   Ensembl cytogenetic band:  9q31.3   HGNC cytogenetic band: 9q31.3

DNAJC25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJC25 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P114393:  view genomic region     (about GC identifiers)

Start:
114,393,632 bp from pter      End:
114,432,508 bp from pter
Size:
38,877 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DJC25_HUMAN, Q9H1X3 (See protein sequence)
Recommended Name: DnaJ homolog subfamily C member 25  
Size: 360 amino acids; 42404 Da
Secondary accessions: Q5QTD8 Q96BN9
Alternative splicing: 3 isoforms:  Q9H1X3-1   Q9H1X3-2   Q9H1X3-3   

Explore the universe of human proteins at neXtProt for DNAJC25: NX_Q9H1X3

Explore proteomics data for DNAJC25 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DNAJC25 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001015882.2  
    ENSEMBL proteins: 
     ENSP00000320650   ENSP00000464086   ENSP00000399325   ENSP00000451984  

    DNAJC25 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for DNAJC25 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    1 InterPro protein domain:
     IPR001623 DnaJ_domain

    Graphical View of Domain Structure for InterPro Entry Q9H1X3

    ProtoNet protein and cluster: Q9H1X3

    UniProtKB/Swiss-Prot: DJC25_HUMAN, Q9H1X3
    Similarity: Belongs to the DNAJC25 family
    Similarity: Contains 1 J domain


    Find genes that share domains with DNAJC25           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity ----
         
    Find genes that share ontologies with DNAJC25           About GenesLikeMe


    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target DNAJC25:
    hsa-mir-124-3p (MIRT022462)

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    Selected qRT-PCR Assays for microRNAs that regulate DNAJC25 (see all 12):
    hsa-miR-3163 hsa-miR-142-5p hsa-miR-4254 hsa-miR-516b hsa-miR-522 hsa-miR-561 hsa-miR-4306 hsa-miR-340
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DJC25_HUMAN, Q9H1X3: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    endoplasmic reticulum2
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005834heterotrimeric G-protein complex ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with DNAJC25           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DNAJC25 About   (see all 18)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ADP signalling through P2Y purinoceptor 12
    G-protein beta-gamma signalling0.90
    ADP signalling through P2Y purinoceptor 120.74
    G beta-gamma signalling through PI3Kgamma0.90
    G-protein activation0.74
    Signal amplification0.79
    Thrombin signalling through proteinase activated receptors (PARs)0.69
    ADP signalling through P2Y purinoceptor 10.79
    Activation of Kainate Receptors upon glutamate binding0.68
    2Inwardly rectifying K+ channels
    Inwardly rectifying K+ channels0.82
    Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits0.82
    G protein gated Potassium channels0.82
    Activation of G protein gated Potassium channels0.82
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Ca2+ pathway0.43
    Signaling by Wnt0.79
    5Integration of energy metabolism
    Integration of energy metabolism0.75
    Regulation of Insulin Secretion by Glucagon-like Peptide-10.56
    Regulation of Insulin Secretion0.75



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DNAJC25
    Interactions:

        Search GeneGlobe Interaction Network for DNAJC25

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for DNAJC25 (Q9H1X33 ENSP000003206504) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNB1P628733, ENSP000003678724I2D: score=1 STRING: ENSP00000367872
    GNB2P628793, ENSP000003052604I2D: score=1 STRING: ENSP00000305260
    SGTAO437653I2D: score=5 
    CLPBENSP000002940534STRING: ENSP00000294053
    TUFMENSP000003224394STRING: ENSP00000322439
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with DNAJC25           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNAJC25 (DJC25)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DNAJC25 gene: 
    NM_001015882.2  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000313525(uc004bfl.3) ENST00000463589 ENST00000447096(uc004bfm.3)
    ENST00000556107
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DNAJC25 (see all 12):
    hsa-miR-3163 hsa-miR-142-5p hsa-miR-4254 hsa-miR-516b hsa-miR-522 hsa-miR-561 hsa-miR-4306 hsa-miR-340
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Primer
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    OriGene qPCR primer pairs and template standards for DNAJC25
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJC25
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      QuantiTect SYBR Green Assays in human, mouse, rat DNAJC25
      QuantiFast Probe-based Assays in human, mouse, rat DNAJC25

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC25 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:                    -                                                         
    SP2:              -     -                                                         
    SP3:                                                                              
    SP4:              -     -     -                                                   
    SP5:                                                                              


    ECgene alternative splicing isoforms for DNAJC25

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNAJC25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DNAJC25 Expression
    About this image

    DNAJC25 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAJC25 Protein Expression
        Custom PCR Arrays for DNAJC25
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNAJC25 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnajc251 , 5 DnaJ (Hsp40) homolog, subfamily C, member 251, 5 87.86(n)1
    91.88(a)1
      4 (32.36 cM)5
    724291  NM_001033165.31  NP_001028337.21 
     589950625 
    chicken
    (Gallus gallus)
    Aves DNAJC251 DnaJ (Hsp40) homolog, subfamily C , member 25 77.49(n)
    80(a)
      431639  XM_003643082.2  XP_003643130.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    74(a)
    1 → many
    GL343476.1(483464-497588)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dnajc251 DnaJ (Hsp40) homolog, subfamily C , member 25 70.36(n)
    77.23(a)
      496999  NM_001011497.1  NP_001011497.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dnajc251 DnaJ (Hsp40) homolog, subfamily C , member 25 69.77(n)
    72.98(a)
      100319235  NM_001205027.1  NP_001191956.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG78721 CG7872 59.39(n)
    55.06(a)
      32493  NM_132816.3  NP_573044.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dnj-21 dnj-2 50.38(n)
    40.66(a)
      178043  NM_069725.4  NP_502126.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G617701 AT1G61770 46.62(n)
    33.58(a)
      842474  NM_104859.2  NP_176370.2 
    rice
    (Oryza sativa)
    Liliopsida Os12g02582001 Os12g0258200 47.36(n)
    34.32(a)
      4351914  NM_001073048.1  NP_001066516.1 


    ENSEMBL Gene Tree for DNAJC25 (if available)
    TreeFam Gene Tree for DNAJC25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNAJC25 gene
    DNAJC25-GNG102  
    3 SIMAP similar genes for DNAJC25 using alignment to 3 protein entries:     DJC25_HUMAN (see all proteins):
    DNAJA2    DNAJA4    DNAJB6

    Find genes that share paralogs with DNAJC25           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DNAJC25:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv893725CNV Loss21882294
    nsv893724CNV Gain21882294
    nsv825041CNV Gain20364138
    nsv893726CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNAJC25 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with DNAJC25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (Nature 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 548645 HGNC: 34187 Ensembl:ENSG00000059769 euGenes: HUgn548645 ECgene: DNAJC25
    H-InvDB: DNAJC25

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DNAJC25 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNAJC25 gene:
    Search GeneIP for patents involving DNAJC25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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