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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DNAJC25 Gene

protein-coding GIFtS: 37
GCID: GC09P114393

DnaJ (Hsp40) Homolog, Subfamily C , Member 25

Search for DNAJC25
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
DnaJ (Hsp40) Homolog, Subfamily C , Member 25¹ ²
bA16L21.2.1²
DnaJ Homolog Subfamily C Member 25²
DnaJ-Like Protein²

External Ids:	HGNC: 34187¹	Entrez Gene: 548645²	Ensembl: ENSG00000059769⁷	UniProtKB: Q9H1X3³

ORGUL members:
	NONCODE¹⁴:n410201

Export aliases for DNAJC25 gene to outside databases

Previous GC identifers: GC09P113444 GC09P113446 GC09P083992

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DNAJC25 Gene:

DNAJC25 (DnaJ (Hsp40) homolog, subfamily C , member 25) is a protein-coding gene, and is affiliated with the lncRNA class. GO annotations related to this gene include unfolded protein binding and heat shock protein binding. An important paralog of this gene is DNAJC25-GNG10.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DNAJC25 gene promoter:
ER-alpha HFH-3 Sox5 p300 C/EBPalpha FOXI1 CREB CHOP-10 deltaCREB HSF2
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for DNAJC25

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJC25

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31.3 Ensembl cytogenetic band: 9q31.3 HGNC cytogenetic band: 9q31.3

DNAJC25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJC25 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P114393: view genomic region (about GC identifiers)

Start:	114,393,632 bp from pter	End:	114,432,508 bp from pter
Size:	38,877 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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About This Section

UniProtKB/Swiss-Prot: DJC25_HUMAN, Q9H1X3 (See protein sequence)

Recommended Name: DnaJ homolog subfamily C member 25

Size: 360 amino acids; 42404 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: Q5QTD8 Q96BN9

Alternative splicing: 3 isoforms: Q9H1X3-1 Q9H1X3-2 Q9H1X3-3

Explore the universe of human proteins at neXtProt for DNAJC25: NX_Q9H1X3

Explore proteomics data for DNAJC25 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9H1X3

DNAJC25 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_001015882.2

ENSEMBL proteins:

ENSP00000320650 ENSP00000464086 ENSP00000399325 ENSP00000451984

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005834	heterotrimeric G-protein complex	--	--
GO:0016021	integral to membrane	IEA	--

DNAJC25 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

DNAJ: Heat shock proteins / DNAJ (HSP40)

1 InterPro protein domain:

IPR001623 DnaJ_domain

Graphical View of Domain Structure for InterPro Entry Q9H1X3

ProtoNet protein and cluster: Q9H1X3

UniProtKB/Swiss-Prot: DJC25_HUMAN, Q9H1X3

Similarity: Belongs to the DNAJC25 family

Similarity: Contains 1 J domain

DNAJC25 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	--	--

DNAJC25 for ontologies About GeneDecksing

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DNAJC25

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

3 Interacting proteins for DNAJC25 (Q9H1X3³ ENSP00000320650⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNB1	P62873³, ENSP00000367872⁴	I2D: score=1 STRING: ENSP00000367872
GNB2	P62879³, ENSP00000305260⁴	I2D: score=1 STRING: ENSP00000305260
SGTA	O43765³	I2D: score=5

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007186	G-protein coupled receptor signaling pathway	--	--

DNAJC25 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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Search CenterWatch for drugs/clinical trials and news about DNAJC25 / DJC25

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for DNAJC25 gene:

NM_001015882.2

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000313525(uc004bfl.3) ENST00000463589 ENST00000447096(uc004bfm.3)

ENST00000556107

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GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC25 (see all 7) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10
SP1:							-
SP2:					-		-
SP3:
SP4:					-		-		-
SP5:

ECgene alternative splicing isoforms for DNAJC25

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DNAJC25 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

See DNAJC25 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DNAJC25

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJC25 gene from 8/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dnajc25^{1 , 5}	DnaJ (Hsp40) homolog, subfamily C, member 25^{1, 5}	88.51(n)¹ 93.1(a)¹		4 (32.36 cM)⁵ 72429¹ NM_001033165.3¹ NP_001028337.2¹ 58995062⁵
chicken (Gallus gallus)	Aves	DNAJC25¹	DnaJ (Hsp40) homolog, subfamily C , member 25	77.52(n) 80.23(a)		431639 XM_003643082.1 XP_003643130.1
lizard (Anolis carolinensis)	Reptilia	DNAJC25⁶	Uncharacterized protein	72(a)	1 ↔ 1	GL343476.1(483464-497588)
zebrafish (Danio rerio)	Actinopterygii	dnajc25¹	DnaJ (Hsp40) homolog, subfamily C , member 25	69.22(n) 72.17(a)		100319235 XM_002662198.1 XP_002662244.1
fruit fly (Drosophila melanogaster)	Insecta	CG7872¹	CG7872	59.71(n) 54.6(a)		32493 NM_132816.2 NP_573044.1
worm (Caenorhabditis elegans)	Secernentea	dnj-2¹	Protein DNJ-2	51.37(n) 42.62(a)		178043 NM_069725.3 NP_502126.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G61770¹	DnaJ domain-containing protein	46.41(n) 35.07(a)		842474 NM_104859.2 NP_176370.2
rice (Oryza sativa)	Liliopsida	Os12g0258200¹	hypothetical protein	48.29(n) 35.34(a)		4351914 NM_001073048.1 NP_001066516.1

ENSEMBL Gene Tree for DNAJC25 (if available)
TreeFam Gene Tree for DNAJC25 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DNAJC25 gene

DNAJC25-GNG10²

3 SIMAP similar genes for DNAJC25 using alignment to 3 protein entries: DJC25_HUMAN (see all proteins):

DNAJA2 DNAJA4 DNAJB6

DNAJC25 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Structural Variations
Database of Genomic Variants (DGV) 4 variations for DNAJC25: About this table

Variant ID	Type	Subtype	PubMed ID
nsv893725	CNV	Loss	21882294
nsv893724	CNV	Gain	21882294
nsv825041	CNV	Gain	20364138
nsv893726	CNV	Gain	21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DNAJC25 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DNAJC25)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)² Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 548645	HGNC: 34187	Ensembl:ENSG00000059769	euGenes: HUgn548645	ECgene: DNAJC25
H-InvDB: DNAJC25

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DNAJC25	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DNAJC25 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DNAJC25 gene:
Search GeneIP for patents involving DNAJC25

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC25

	inGenious Targeting Laboratory - Custom generated mouse model solutions for DNAJC25
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
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DNAJC25 Gene

DnaJ (Hsp40) Homolog, Subfamily C , Member 25

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DNAJC25 Gene

DnaJ (Hsp40) Homolog, Subfamily C , Member 25

Aliasesfor DNAJC25 gene

Summariesfor DNAJC25 gene

Genomic Viewsfor DNAJC25 gene

Proteinsfor DNAJC25 gene

Protein Domains /Familiesfor DNAJC25 gene

Functionfor DNAJC25 gene

Pathways & Interactionsfor DNAJC25 gene

Drugs & Compoundsfor DNAJC25 gene

Transcriptsfor DNAJC25 gene

Expression for DNAJC25 gene

Orthologsfor DNAJC25 gene

Paralogsfor DNAJC25 gene

Genomic Variantsfor DNAJC25 gene

Disorders / Diseasesfor DNAJC25 gene

Publicationsfor DNAJC25 gene

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Genome Databases showing DNAJC25 gene

Other Databases showing DNAJC25 gene

Specialized Databases showing DNAJC25 gene

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for DNAJC25 gene

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for DNAJC25 gene

Genomic Views
for DNAJC25 gene

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for DNAJC25 gene

Protein Domains /
Families
for DNAJC25 gene

Function
for DNAJC25 gene

Pathways & Interactions
for DNAJC25 gene

Drugs & Compounds
for DNAJC25 gene

Transcripts
for DNAJC25 gene

Expression
for DNAJC25 gene

Orthologs
for DNAJC25 gene

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for DNAJC25 gene

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for DNAJC25 gene

Disorders / Diseases
for DNAJC25 gene

Publications
for DNAJC25 gene

Intellectual Property
for DNAJC25 gene

Products
for DNAJC25 gene