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Aliases for DNAJC24 Gene

Aliases for DNAJC24 Gene

  • DnaJ (Hsp40) Homolog, Subfamily C, Member 24 2 3
  • DPH4 3 4 6
  • CSL-Type Zinc Finger-Containing Protein 3 3 4
  • Zinc Finger, CSL-Type Containing 3 2 3
  • DPH4 Homolog (JJJ3, S. Cerevisiae) 2 3
  • Diphthamide Biosynthesis Protein 4 3 4
  • ZCSL3 3 4
  • Zinc Finger, CSL Domain Containing 3 3
  • DPH4, JJJ3 Homolog (S. Cerevisiae) 2
  • DnaJ Homolog Subfamily C Member 24 3
  • DPH4, JJJ3 Homolog 3
  • 1700030A21Rik 3
  • JJJ3 3

External Ids for DNAJC24 Gene

Previous Symbols for DNAJC24 Gene

  • ZCSL3
  • DPH4

Summaries for DNAJC24 Gene

Entrez Gene Summary for DNAJC24 Gene

  • Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH4 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM, Mar 2008]

GeneCards Summary for DNAJC24 Gene

DNAJC24 (DnaJ (Hsp40) Homolog, Subfamily C, Member 24) is a Protein Coding gene. GO annotations related to this gene include ferrous iron binding and ATPase activator activity.

UniProtKB/Swiss-Prot for DNAJC24 Gene

  • Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC24 Gene

Genomics for DNAJC24 Gene

Genomic Location for DNAJC24 Gene

Start:
31,369,830 bp from pter
End:
31,432,835 bp from pter
Size:
63,006 bases
Orientation:
Plus strand

Genomic View for DNAJC24 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJC24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC24 Gene

Regulatory Elements for DNAJC24 Gene

Proteins for DNAJC24 Gene

  • Protein details for DNAJC24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P3W2-DJC24_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 24
    Protein Accession:
    Q6P3W2
    Secondary Accessions:
    • A8K0V0
    • B1ALC1
    • I6L9B4

    Protein attributes for DNAJC24 Gene

    Size:
    148 amino acids
    Molecular mass:
    17008 Da
    Quaternary structure:
    • Monomer and homooligomer. Iron binding promotes oligomerization.
    SequenceCaution:
    • Sequence=EAW68245.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DNAJC24 Gene

    Alternative splice isoforms for DNAJC24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJC24 Gene

Proteomics data for DNAJC24 Gene at MOPED

Post-translational modifications for DNAJC24 Gene

No Post-translational modifications

Other Protein References for DNAJC24 Gene

No data available for DME Specific Peptides for DNAJC24 Gene

Domains for DNAJC24 Gene

Gene Families for DNAJC24 Gene

HGNC:
  • DNAJ :Heat shock proteins / DNAJ (HSP40)

Protein Domains for DNAJC24 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DNAJC24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P3W2

UniProtKB/Swiss-Prot:

DJC24_HUMAN
Domain:
  • The DPH-type zinc finger can also bind iron ions instead of the expected zinc ions.:
    • Q6P3W2
  • Contains 1 J domain.:
    • Q6P3W2
Family:
  • Belongs to the DPH4 family.:
    • Q6P3W2
Similarity:
  • Contains 1 DPH-type zinc finger.:
    • Q6P3W2
genes like me logo Genes that share domains with DNAJC24: view

Function for DNAJC24 Gene

Molecular function for DNAJC24 Gene

UniProtKB/Swiss-Prot Function: Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).

Gene Ontology (GO) - Molecular Function for DNAJC24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity IDA 22367199
GO:0008198 ferrous iron binding IDA 22367199
GO:0008270 zinc ion binding IDA 22367199
genes like me logo Genes that share ontologies with DNAJC24: view
genes like me logo Genes that share phenotypes with DNAJC24: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DNAJC24 Gene

Localization for DNAJC24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC24 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJC24 Gene COMPARTMENTS Subcellular localization image for DNAJC24 gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DNAJC24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with DNAJC24: view

Pathways for DNAJC24 Gene

SuperPathways for DNAJC24 Gene

No Data Available

UniProtKB/Swiss-Prot Q6P3W2-DJC24_HUMAN

  • Pathway: Protein modification; peptidyl-diphthamide biosynthesis

Interacting Proteins for DNAJC24 Gene

Gene Ontology (GO) - Biological Process for DNAJC24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine IEA --
GO:0032781 positive regulation of ATPase activity IDA 22367199
GO:0055114 oxidation-reduction process IEA --
GO:0061077 chaperone-mediated protein folding TAS 22367199
genes like me logo Genes that share ontologies with DNAJC24: view

No data available for Pathways by source for DNAJC24 Gene

Transcripts for DNAJC24 Gene

Unigene Clusters for DNAJC24 Gene

DnaJ (Hsp40) homolog, subfamily C, member 24:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC24 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: - - - - - -
SP2: - - - -
SP3:
SP4: - - -
SP5: - - - - - - -
SP6:

Relevant External Links for DNAJC24 Gene

GeneLoc Exon Structure for
DNAJC24
ECgene alternative splicing isoforms for
DNAJC24

Expression for DNAJC24 Gene

mRNA expression in normal human tissues for DNAJC24 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJC24 Gene

SOURCE GeneReport for Unigene cluster for DNAJC24 Gene Hs.187269

genes like me logo Genes that share expressions with DNAJC24: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DNAJC24 Gene

Orthologs for DNAJC24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DNAJC24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC24 35
  • 100 (n)
  • 100 (a)
DNAJC24 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAJC24 35
  • 91.67 (n)
  • 89.19 (a)
DNAJC24 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJC24 35
  • 92.17 (n)
  • 88.59 (a)
mouse
(Mus musculus)
Mammalia Dnajc24 35
  • 83.56 (n)
  • 84.93 (a)
Dnajc24 16
Dnajc24 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNAJC24 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC24 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajc24 35
  • 83.56 (n)
  • 83.56 (a)
chicken
(Gallus gallus)
Aves DNAJC24 35
  • 72.83 (n)
  • 66.44 (a)
DNAJC24 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 66 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc24 35
  • 60.23 (n)
  • 54.48 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11140 35
zebrafish
(Danio rerio)
Actinopterygii dnajc24 35
  • 60.42 (n)
  • 50.69 (a)
dnajc24 36
  • 48 (a)
OneToOne
Species with no ortholog for DNAJC24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAJC24 Gene

ENSEMBL:
Gene Tree for DNAJC24 (if available)
TreeFam:
Gene Tree for DNAJC24 (if available)

Paralogs for DNAJC24 Gene

Pseudogenes.org Pseudogenes for DNAJC24 Gene

genes like me logo Genes that share paralogs with DNAJC24: view

No data available for Paralogs for DNAJC24 Gene

Variants for DNAJC24 Gene

Sequence variations from dbSNP and Humsavar for DNAJC24 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs479005 -- 31,376,155(+) gctct(C/T)attct intron-variant
rs481683 -- 31,385,884(+) ccatc(C/T)ctccc intron-variant
rs483534 -- 31,376,595(+) GCTTA(C/G)TTACA intron-variant
rs483633 -- 31,376,638(+) AAGGG(G/T)TATGA intron-variant
rs485265 -- 31,386,241(+) tccac(A/G)tgacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC24 Gene

Variant ID Type Subtype PubMed ID
nsv529004 CNV Loss 19592680
esv2751022 CNV Loss 17911159
nsv832106 CNV Gain 17160897
nsv897178 CNV Loss 21882294
nsv7725 CNV Loss 18451855
nsv508621 CNV Loss 20534489
nsv467784 CNV Loss 19166990
dgv205n67 CNV Loss 20364138
nsv820987 CNV Deletion 20802225
nsv820247 CNV Gain 19587683
dgv197e199 CNV Deletion 23128226
nsv498752 CNV Loss 21111241
esv22237 CNV Gain+Loss 19812545
esv2744311 CNV Deletion 23290073
nsv514608 CNV Loss 21397061
esv2744312 CNV Deletion 23290073
nsv897179 CNV Loss 21882294
esv1006845 CNV Loss 20482838

Relevant External Links for DNAJC24 Gene

HapMap Linkage Disequilibrium report
DNAJC24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC24 Gene

Disorders for DNAJC24 Gene

(1) University of Copenhagen DISEASES for DNAJC24 Gene

genes like me logo Genes that share disorders with DNAJC24: view

No data available for UniProtKB/Swiss-Prot for DNAJC24 Gene

Publications for DNAJC24 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2. (PMID: 15485916) Liu S. … Leppla S.H. (Mol. Cell. Biol. 2004) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Structure and mechanistic insights into novel iron-mediated moonlighting functions of human J-protein cochaperone, Dph4. (PMID: 22367199) Thakur A. … D'Silva P. (J. Biol. Chem. 2012) 3 4
  5. Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy. (PMID: 22509046) Wei H. … Pastan I. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 4

Products for DNAJC24 Gene

Sources for DNAJC24 Gene

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