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Aliases for DNAJC24 Gene

Aliases for DNAJC24 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C24 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 24 2 3
  • CSL-Type Zinc Finger-Containing Protein 3 3 4
  • Zinc Finger, CSL-Type Containing 3 2 3
  • DPH4 Homolog (JJJ3, S. Cerevisiae) 2 3
  • Diphthamide Biosynthesis Protein 4 3 4
  • ZCSL3 3 4
  • DPH4 3 4
  • Zinc Finger, CSL Domain Containing 3 3
  • DPH4, JJJ3 Homolog (S. Cerevisiae) 2
  • DnaJ Homolog Subfamily C Member 24 3
  • DPH4, JJJ3 Homolog 3
  • 1700030A21Rik 3
  • JJJ3 3

External Ids for DNAJC24 Gene

Previous HGNC Symbols for DNAJC24 Gene

  • ZCSL3
  • DPH4

Previous GeneCards Identifiers for DNAJC24 Gene

  • GC11P031085

Summaries for DNAJC24 Gene

Entrez Gene Summary for DNAJC24 Gene

  • Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH4 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM, Mar 2008]

GeneCards Summary for DNAJC24 Gene

DNAJC24 (DnaJ Heat Shock Protein Family (Hsp40) Member C24) is a Protein Coding gene. Diseases associated with DNAJC24 include Diphtheria. Among its related pathways are Metabolism of proteins and Gamma carboxylation, hypusine formation and arylsulfatase activation. GO annotations related to this gene include ferrous iron binding and ATPase activator activity.

UniProtKB/Swiss-Prot for DNAJC24 Gene

  • Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC24 Gene

Genomics for DNAJC24 Gene

Regulatory Elements for DNAJC24 Gene

Enhancers for DNAJC24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G031143 0.3 FANTOM5 4.2 -225.8 -225825 0.0 DNAJC24 IMMP1L ELP4 GC11P031127 GC11M031165
GH11G031369 1.1 ENCODE 0.7 +0.2 168 1.6 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 DCDC1 DNAJC24 GC11M031425
GH11G031429 0.3 FANTOM5 1.9 +59.4 59437 0.1 DNAJC24 PAX6 ELP4 IMMP1L GC11M031425
GH11G031480 1.7 VISTA 0.1 +111.2 111235 1.1 POLR2A SMARCA4 REST GC11M031425 DNAJC24
GH11G031421 0.2 ENCODE 0.2 +52.2 52181 0.2 DNAJC24 GC11M031425
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DNAJC24 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJC24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000038378 86 1800 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766

Genomic Location for DNAJC24 Gene

Chromosome:
11
Start:
31,369,815 bp from pter
End:
31,432,835 bp from pter
Size:
63,021 bases
Orientation:
Plus strand

Genomic View for DNAJC24 Gene

Genes around DNAJC24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC24 Gene

Proteins for DNAJC24 Gene

  • Protein details for DNAJC24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P3W2-DJC24_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 24
    Protein Accession:
    Q6P3W2
    Secondary Accessions:
    • A8K0V0
    • B1ALC1
    • I6L9B4

    Protein attributes for DNAJC24 Gene

    Size:
    148 amino acids
    Molecular mass:
    17008 Da
    Quaternary structure:
    • Monomer and homooligomer. Iron binding promotes oligomerization.
    SequenceCaution:
    • Sequence=EAW68245.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DNAJC24 Gene

    Alternative splice isoforms for DNAJC24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJC24 Gene

Post-translational modifications for DNAJC24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJC24 Gene

No data available for DME Specific Peptides for DNAJC24 Gene

Domains & Families for DNAJC24 Gene

Gene Families for DNAJC24 Gene

Protein Domains for DNAJC24 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DNAJC24 Gene

Graphical View of Domain Structure for InterPro Entry

Q6P3W2

UniProtKB/Swiss-Prot:

DJC24_HUMAN :
  • The DPH-type zinc finger can also bind iron ions instead of the expected zinc ions.
  • Belongs to the DPH4 family.
Domain:
  • The DPH-type zinc finger can also bind iron ions instead of the expected zinc ions.
Family:
  • Belongs to the DPH4 family.
genes like me logo Genes that share domains with DNAJC24: view

Function for DNAJC24 Gene

Molecular function for DNAJC24 Gene

UniProtKB/Swiss-Prot Function:
Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).

Gene Ontology (GO) - Molecular Function for DNAJC24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity IDA 22367199
GO:0008198 ferrous iron binding IDA 22367199
GO:0008270 zinc ion binding IDA 22367199
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DNAJC24: view
genes like me logo Genes that share phenotypes with DNAJC24: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJC24 Gene

Localization for DNAJC24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC24 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJC24 gene
Compartment Confidence
cytosol 4
cytoskeleton 3
extracellular 2
plasma membrane 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DNAJC24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DNAJC24: view

Pathways & Interactions for DNAJC24 Gene

genes like me logo Genes that share pathways with DNAJC24: view

UniProtKB/Swiss-Prot Q6P3W2-DJC24_HUMAN

  • Pathway: Protein modification; peptidyl-diphthamide biosynthesis.

Gene Ontology (GO) - Biological Process for DNAJC24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine IEA --
GO:0032781 positive regulation of ATPase activity IDA 22367199
GO:0055114 oxidation-reduction process IEA --
GO:0061077 chaperone-mediated protein folding TAS 22367199
genes like me logo Genes that share ontologies with DNAJC24: view

No data available for SIGNOR curated interactions for DNAJC24 Gene

Drugs & Compounds for DNAJC24 Gene

No Compound Related Data Available

Transcripts for DNAJC24 Gene

Unigene Clusters for DNAJC24 Gene

DnaJ (Hsp40) homolog, subfamily C, member 24:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC24 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: - - - - - -
SP2: - - - -
SP3:
SP4: - - -
SP5: - - - - - - -
SP6:

Relevant External Links for DNAJC24 Gene

GeneLoc Exon Structure for
DNAJC24
ECgene alternative splicing isoforms for
DNAJC24

Expression for DNAJC24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJC24 Gene

Protein differential expression in normal tissues from HIPED for DNAJC24 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNAJC24 Gene



Protein tissue co-expression partners for DNAJC24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJC24 Gene:

DNAJC24

SOURCE GeneReport for Unigene cluster for DNAJC24 Gene:

Hs.187269

Evidence on tissue expression from TISSUES for DNAJC24 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with DNAJC24: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJC24 Gene

Orthologs for DNAJC24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DNAJC24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC24 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia DNAJC24 34
  • 92.17 (n)
cow
(Bos Taurus)
Mammalia DNAJC24 34 35
  • 91.67 (n)
mouse
(Mus musculus)
Mammalia Dnajc24 34 16 35
  • 83.56 (n)
rat
(Rattus norvegicus)
Mammalia Dnajc24 34
  • 83.56 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC24 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNAJC24 35
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJC24 34 35
  • 72.83 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 66 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc24 34
  • 60.23 (n)
zebrafish
(Danio rerio)
Actinopterygii dnajc24 34 35
  • 60.42 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11140 34
Species where no ortholog for DNAJC24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAJC24 Gene

ENSEMBL:
Gene Tree for DNAJC24 (if available)
TreeFam:
Gene Tree for DNAJC24 (if available)

Paralogs for DNAJC24 Gene

Pseudogenes.org Pseudogenes for DNAJC24 Gene

genes like me logo Genes that share paralogs with DNAJC24: view

No data available for Paralogs for DNAJC24 Gene

Variants for DNAJC24 Gene

Sequence variations from dbSNP and Humsavar for DNAJC24 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_036397 A breast cancer sample
rs1000028266 -- 31,410,022(+) GGGAC(C/T)ACTGG intron-variant
rs1000072464 -- 31,429,302(+) GCAGG(A/T)ACAAG intron-variant
rs1000099716 -- 31,390,478(+) CAAGG(A/G)GAGCG intron-variant
rs1000101524 -- 31,410,368(+) TCTGG(C/T)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC24 Gene

Variant ID Type Subtype PubMed ID
dgv1734n54 CNV loss 21841781
dgv1735n54 CNV loss 21841781
dgv1736n54 CNV gain+loss 21841781
dgv1737n54 CNV loss 21841781
dgv1738n54 CNV loss 21841781
dgv1739n54 CNV loss 21841781
dgv197e199 CNV deletion 23128226
dgv205n67 CNV loss 20364138
dgv30n73 CNV deletion 24416366
dgv611n106 CNV deletion 24896259
esv1006845 CNV loss 20482838
esv22237 CNV gain+loss 19812545
esv2744311 CNV deletion 23290073
esv2744312 CNV deletion 23290073
esv2751022 CNV loss 17911159
esv3547538 CNV deletion 23714750
esv3625827 CNV loss 21293372
esv3625828 CNV gain 21293372
esv3625829 CNV loss 21293372
nsv1040432 CNV loss 25217958
nsv1042013 CNV loss 25217958
nsv1046329 CNV loss 25217958
nsv1069570 CNV deletion 25765185
nsv467784 CNV loss 19166990
nsv498752 CNV loss 21111241
nsv508621 CNV deletion 20534489
nsv514608 CNV loss 21397061
nsv529004 CNV loss 19592680
nsv553949 CNV loss 21841781
nsv553950 CNV loss 21841781
nsv553954 CNV loss 21841781
nsv553970 CNV gain 21841781
nsv553976 CNV gain+loss 21841781
nsv553983 CNV loss 21841781
nsv7725 CNV deletion 18451855
nsv820247 CNV gain 19587683
nsv820987 CNV deletion 20802225
nsv832106 CNV gain 17160897

Variation tolerance for DNAJC24 Gene

Residual Variation Intolerance Score: 59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJC24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC24 Gene

Disorders for DNAJC24 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DNAJC24 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
diphtheria
  • corynebacterium infection
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DNAJC24

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJC24
genes like me logo Genes that share disorders with DNAJC24: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNAJC24 Gene

Publications for DNAJC24 Gene

  1. Structure and mechanistic insights into novel iron-mediated moonlighting functions of human J-protein cochaperone, Dph4. (PMID: 22367199) Thakur A. … D'Silva P. (J. Biol. Chem. 2012) 3 4 64
  2. Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy. (PMID: 22509046) Wei H. … Pastan I. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 4 64
  3. Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2. (PMID: 15485916) Liu S. … Leppla S.H. (Mol. Cell. Biol. 2004) 2 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for DNAJC24 Gene

Sources for DNAJC24 Gene

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