Aliases for DNAJC24 Gene
External Ids for DNAJC24 Gene
Previous HGNC Symbols for DNAJC24 Gene
Previous GeneCards Identifiers for DNAJC24 Gene
Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH4 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM, Mar 2008]
GeneCards Summary for DNAJC24 Gene
DNAJC24 (DnaJ (Hsp40) Homolog, Subfamily C, Member 24) is a Protein Coding gene. GO annotations related to this gene include ferrous iron binding and ATPase activator activity.
UniProtKB/Swiss-Prot for DNAJC24 Gene
Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).