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Aliases for DNAJC22 Gene

Aliases for DNAJC22 Gene

  • DnaJ (Hsp40) Homolog, Subfamily C, Member 22 2 3
  • DnaJ Homolog Subfamily C Member 22 3
  • Wurst Homolog (Drosophila) 2
  • Wurst Homolog 3
  • Wus 3

External Ids for DNAJC22 Gene

Summaries for DNAJC22 Gene

GeneCards Summary for DNAJC22 Gene

DNAJC22 (DnaJ (Hsp40) Homolog, Subfamily C, Member 22) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DNAJC22 Gene

  • May function as a co-chaperone

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC22 Gene

Genomics for DNAJC22 Gene

Genomic Location for DNAJC22 Gene

Start:
49,346,917 bp from pter
End:
49,357,546 bp from pter
Size:
10,630 bases
Orientation:
Plus strand

Genomic View for DNAJC22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJC22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC22 Gene

Regulatory Elements for DNAJC22 Gene

Proteins for DNAJC22 Gene

  • Protein details for DNAJC22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4W6-DJC22_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 22
    Protein Accession:
    Q8N4W6
    Secondary Accessions:
    • B3KP54

    Protein attributes for DNAJC22 Gene

    Size:
    341 amino acids
    Molecular mass:
    38086 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DNAJC22 Gene

Proteomics data for DNAJC22 Gene at MOPED

Post-translational modifications for DNAJC22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJC22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJC22 Gene

Domains for DNAJC22 Gene

Gene Families for DNAJC22 Gene

HGNC:
  • DNAJ :Heat shock proteins / DNAJ (HSP40)

Protein Domains for DNAJC22 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

DJC22_HUMAN
Domain:
  • Contains 1 J domain.:
    • Q8N4W6
genes like me logo Genes that share domains with DNAJC22: view

Function for DNAJC22 Gene

Molecular function for DNAJC22 Gene

UniProtKB/Swiss-Prot Function: May function as a co-chaperone

Gene Ontology (GO) - Molecular Function for DNAJC22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051082 unfolded protein binding IBA --
GO:0051087 chaperone binding IBA --
genes like me logo Genes that share ontologies with DNAJC22: view

Phenotypes for DNAJC22 Gene

genes like me logo Genes that share phenotypes with DNAJC22: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DNAJC22 Gene

Localization for DNAJC22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC22 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJC22 Gene COMPARTMENTS Subcellular localization image for DNAJC22 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DNAJC22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DNAJC22: view

Pathways for DNAJC22 Gene

SuperPathways for DNAJC22 Gene

No Data Available

Interacting Proteins for DNAJC22 Gene

Gene Ontology (GO) - Biological Process for DNAJC22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042026 protein refolding IBA --
genes like me logo Genes that share ontologies with DNAJC22: view

No data available for Pathways by source for DNAJC22 Gene

Transcripts for DNAJC22 Gene

Unigene Clusters for DNAJC22 Gene

DnaJ (Hsp40) homolog, subfamily C, member 22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC22 Gene

No ASD Table

Relevant External Links for DNAJC22 Gene

GeneLoc Exon Structure for
DNAJC22
ECgene alternative splicing isoforms for
DNAJC22

Expression for DNAJC22 Gene

mRNA expression in normal human tissues for DNAJC22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAJC22 Gene

This gene is overexpressed in Liver (18.3), Colon - Transverse (5.0), and Pancreas (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DNAJC22 Gene

SOURCE GeneReport for Unigene cluster for DNAJC22 Gene Hs.659300

genes like me logo Genes that share expressions with DNAJC22: view

Orthologs for DNAJC22 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAJC22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC22 36
  • 99.22 (n)
  • 98.53 (a)
DNAJC22 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAJC22 36
  • 87.59 (n)
  • 82.99 (a)
DNAJC22 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJC22 36
  • 89.09 (n)
  • 87.32 (a)
DNAJC22 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajc22 36
  • 85.22 (n)
  • 83.04 (a)
Dnajc22 16
Dnajc22 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNAJC22 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC22 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajc22 36
  • 84.85 (n)
  • 82.11 (a)
lizard
(Anolis carolinensis)
Reptilia DNAJC22 37
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc22 36
  • 60.3 (n)
  • 60.3 (a)
zebrafish
(Danio rerio)
Actinopterygii dnajc22 36
  • 57.24 (n)
  • 52.58 (a)
dnajc22 37
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007138 36
  • 45.51 (n)
  • 32.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta wus 36
  • 45.64 (n)
  • 33.99 (a)
wus 37
  • 25 (a)
OneToOne
Species with no ortholog for DNAJC22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAJC22 Gene

ENSEMBL:
Gene Tree for DNAJC22 (if available)
TreeFam:
Gene Tree for DNAJC22 (if available)

Paralogs for DNAJC22 Gene

No data available for Paralogs for DNAJC22 Gene

Variants for DNAJC22 Gene

Sequence variations from dbSNP and Humsavar for DNAJC22 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1874909 -- 49,348,153(-) ATCTG(A/G)AGCGA intron-variant
rs1874910 -- 49,348,125(-) CTACT(C/T)CCAAA intron-variant
rs1874911 -- 49,347,755(-) AAGGG(C/G)GGGTC intron-variant, upstream-variant-2KB
rs2270741 -- 49,347,194(-) TCCTG(A/C)GCCTC upstream-variant-2KB, utr-variant-5-prime
rs2277373 -- 49,349,580(-) AGAAG(A/G)AGGAC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for DNAJC22 Gene

Variant ID Type Subtype PubMed ID
dgv1423n71 CNV Loss 21882294
nsv832405 CNV Gain 17160897

Relevant External Links for DNAJC22 Gene

HapMap Linkage Disequilibrium report
DNAJC22

Disorders for DNAJC22 Gene

(1) University of Copenhagen DISEASES for DNAJC22 Gene

genes like me logo Genes that share disorders with DNAJC22: view

No data available for UniProtKB/Swiss-Prot for DNAJC22 Gene

Publications for DNAJC22 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Wurst is essential for airway clearance and respiratory-tube size control. (PMID: 17558392) Behr M. … Hoch M. (Nat. Cell Biol. 2007) 2 3
  3. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung M.L. … Jeang K.T. (J. Biol. Chem. 2009) 3
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for DNAJC22 Gene

Sources for DNAJC22 Gene

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