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Aliases for DNAJC22 Gene

Aliases for DNAJC22 Gene

  • DnaJ (Hsp40) Homolog, Subfamily C, Member 22 2 3
  • Wurst Homolog (Drosophila) 2
  • Wurst Homolog 3
  • Wus 3

External Ids for DNAJC22 Gene

Previous GeneCards Identifiers for DNAJC22 Gene

  • GC12P048028
  • GC12P049740
  • GC12P046771

Summaries for DNAJC22 Gene

GeneCards Summary for DNAJC22 Gene

DNAJC22 (DnaJ (Hsp40) Homolog, Subfamily C, Member 22) is a Protein Coding gene. GO annotations related to this gene include unfolded protein binding and chaperone binding.

UniProtKB/Swiss-Prot for DNAJC22 Gene

  • May function as a co-chaperone

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC22 Gene

Genomics for DNAJC22 Gene

Regulatory Elements for DNAJC22 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DNAJC22 Gene

Chromosome:
12
Start:
49,346,917 bp from pter
End:
49,357,546 bp from pter
Size:
10,630 bases
Orientation:
Plus strand

Genomic View for DNAJC22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJC22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC22 Gene

Proteins for DNAJC22 Gene

  • Protein details for DNAJC22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4W6-DJC22_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 22
    Protein Accession:
    Q8N4W6
    Secondary Accessions:
    • B3KP54

    Protein attributes for DNAJC22 Gene

    Size:
    341 amino acids
    Molecular mass:
    38086 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DNAJC22 Gene

Proteomics data for DNAJC22 Gene at MOPED

Post-translational modifications for DNAJC22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJC22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJC22 Gene

Domains & Families for DNAJC22 Gene

Gene Families for DNAJC22 Gene

Protein Domains for DNAJC22 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DNAJC22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4W6

UniProtKB/Swiss-Prot:

DJC22_HUMAN :
  • Contains 1 J domain.
Domain:
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJC22: view

Function for DNAJC22 Gene

Molecular function for DNAJC22 Gene

UniProtKB/Swiss-Prot Function:
May function as a co-chaperone

Gene Ontology (GO) - Molecular Function for DNAJC22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051082 unfolded protein binding IBA --
GO:0051087 chaperone binding IBA --
genes like me logo Genes that share ontologies with DNAJC22: view
genes like me logo Genes that share phenotypes with DNAJC22: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJC22

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJC22 Gene

Localization for DNAJC22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC22 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for DNAJC22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DNAJC22: view

No data available for Subcellular locations from COMPARTMENTS for DNAJC22 Gene

Pathways & Interactions for DNAJC22 Gene

SuperPathways for DNAJC22 Gene

No Data Available

Interacting Proteins for DNAJC22 Gene

Gene Ontology (GO) - Biological Process for DNAJC22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042026 protein refolding IBA --
genes like me logo Genes that share ontologies with DNAJC22: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJC22 Gene

Drugs & Compounds for DNAJC22 Gene

No Compound Related Data Available

Transcripts for DNAJC22 Gene

Unigene Clusters for DNAJC22 Gene

DnaJ (Hsp40) homolog, subfamily C, member 22:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJC22

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC22 Gene

No ASD Table

Relevant External Links for DNAJC22 Gene

GeneLoc Exon Structure for
DNAJC22
ECgene alternative splicing isoforms for
DNAJC22

Expression for DNAJC22 Gene

mRNA expression in normal human tissues for DNAJC22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAJC22 Gene

This gene is overexpressed in Liver (x18.3), Colon - Transverse (x5.0), and Pancreas (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DNAJC22 Gene



SOURCE GeneReport for Unigene cluster for DNAJC22 Gene Hs.659300

genes like me logo Genes that share expression patterns with DNAJC22: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DNAJC22 Gene

Orthologs for DNAJC22 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAJC22 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNAJC22 35
  • 87.59 (n)
  • 82.99 (a)
DNAJC22 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJC22 35
  • 89.09 (n)
  • 87.32 (a)
DNAJC22 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajc22 35
  • 85.22 (n)
  • 83.04 (a)
Dnajc22 16
Dnajc22 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DNAJC22 35
  • 99.22 (n)
  • 98.53 (a)
DNAJC22 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajc22 35
  • 84.85 (n)
  • 82.11 (a)
oppossum
(Monodelphis domestica)
Mammalia DNAJC22 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC22 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJC22 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc22 35
  • 60.3 (n)
  • 60.3 (a)
zebrafish
(Danio rerio)
Actinopterygii dnajc22 35
  • 57.24 (n)
  • 52.58 (a)
dnajc22 36
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007138 35
  • 45.51 (n)
  • 32.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta wus 35
  • 45.64 (n)
  • 33.99 (a)
wus 36
  • 25 (a)
OneToOne
Species with no ortholog for DNAJC22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAJC22 Gene

ENSEMBL:
Gene Tree for DNAJC22 (if available)
TreeFam:
Gene Tree for DNAJC22 (if available)

Paralogs for DNAJC22 Gene

No data available for Paralogs for DNAJC22 Gene

Variants for DNAJC22 Gene

Sequence variations from dbSNP and Humsavar for DNAJC22 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1135757 -- 49,353,391(+) tgcct(A/G)taatc utr-variant-3-prime
rs1135758 -- 49,353,399(+) atcct(A/G)gcact utr-variant-3-prime
rs1874909 -- 49,348,153(-) ATCTG(A/G)AGCGA intron-variant
rs1874910 -- 49,348,125(-) CTACT(C/T)CCAAA intron-variant
rs1874911 -- 49,347,755(-) AAGGG(C/G)GGGTC utr-variant-5-prime, intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DNAJC22 Gene

Variant ID Type Subtype PubMed ID
dgv1423n71 CNV Loss 21882294
nsv832405 CNV Gain 17160897

Variation tolerance for DNAJC22 Gene

Residual Variation Intolerance Score: 61.85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC22 Gene

HapMap Linkage Disequilibrium report
DNAJC22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC22 Gene

Disorders for DNAJC22 Gene

Relevant External Links for DNAJC22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJC22
genes like me logo Genes that share disorders with DNAJC22: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC22 Gene

Publications for DNAJC22 Gene

  1. Wurst is essential for airway clearance and respiratory-tube size control. (PMID: 17558392) Behr M. … Hoch M. (Nat. Cell Biol. 2007) 2 67
  2. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung M.L. … Jeang K.T. (J. Biol. Chem. 2009) 67
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for DNAJC22 Gene

Sources for DNAJC22 Gene

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