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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DNAJC22 Gene

protein-coding   GIFtS: 40
GCID: GC12P049740

DnaJ (Hsp40) homolog, subfamily C, member 22
 Explore 1 disease affiliated with
DNAJC22 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DNAJC22    

Aliases
for DNAJC22 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
DnaJ (Hsp40) Homolog, Subfamily C, Member 221 2
Wus1
FLJ132361
DnaJ Homolog Subfamily C Member 222
Wurst Homolog2

External Ids:    HGNC: 258021   Entrez Gene: 799622   Ensembl: ENSG000001784017   UniProtKB: Q8N4W63   

Export aliases for DNAJC22 gene to outside databases

Previous GC identifers: GC12P048028 GC12P046771


Summaries
for DNAJC22 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: DJC22_HUMAN, Q8N4W6
Function: May function as a co-chaperone




Genomic Views
for DNAJC22 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DNAJC22 gene promoter:
         GR   STAT1   GR-beta   STAT1beta   STAT1alpha   S8   STAT2   STAT3   PPAR-gamma2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DNAJC22 promoter sequence
   Search SABiosciences Chromatin IP Primers for DNAJC22

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJC22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.12   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13.12

DNAJC22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJC22 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P049740:  view genomic region     (about GC identifiers)

Start:
 49,740,700 bp from pter      End:
 49,751,309 bp from pter
Size:
 10,610 bases      Orientation:
 plus strand

Proteins
for DNAJC22 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DJC22_HUMAN, Q8N4W6 (See protein sequence)
Recommended Name: DnaJ homolog subfamily C member 22  
Size: 341 amino acids; 38086 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B3KP54

Explore the universe of human proteins at neXtProt for DNAJC22: NX_Q8N4W6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N4W6

    • DNAJC22 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins: NP_079178.2  
    ENSEMBL proteins: 
     ENSP00000446830   ENSP00000378508  

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    Uscn Proteins for DNAJC22

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    DNAJC22 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DNAJC22

    Protein Domains /
    Families
    for DNAJC22 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DNAJC22 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001623 DnaJ_domain
     IPR007829 TM2

    Graphical View of Domain Structure for InterPro Entry Q8N4W6

    ProtoNet protein and cluster: Q8N4W6

    UniProtKB/Swiss-Prot: DJC22_HUMAN, Q8N4W6
    Similarity: Contains 1 J domain


    Function
    for DNAJC22 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DJC22_HUMAN, Q8N4W6
    Function: May function as a co-chaperone

    miRNA
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    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031072heat shock protein binding IEA--
    GO:0051082unfolded protein binding IEA--


    DNAJC22 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for DNAJC22:
     Decreased Wnt reporter activit  Decreased viability of wild-ty 


    Pathways & Interactions
    for DNAJC22 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNAJC22

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--


    DNAJC22 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DNAJC22 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DNAJC22
    Search CenterWatch for drugs/clinical trials and news about DNAJC22 / DJC22 

    Transcripts
    for DNAJC22 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DNAJC22 gene: 
    NM_024902.2  

    Unigene Cluster for DNAJC22:

    DnaJ (Hsp40) homolog, subfamily C, member 22
    Hs.659300  [show with all ESTs]
    Unigene Representative Sequence: AK055747
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000549441(uc001rub.3) ENST00000395069(uc001rua.3) ENST00000551153
    ENST00000552651

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNAJC22 (see all 4)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK055747.1 BC033236.1 

    2 DOTS entries:

    DT.111214  DT.92060035 

    24/62 AceView cDNA sequences (see all 62):

    AW296823 BX280191 BM875391 CA441318 N27004 AA905621 CK823992 AA128225 
    AA057729 AI972026 BU603025 BC033236 BG422336 BX106436 N66049 AA057730 
    W84881 AA732837 AI916128 BP359131 NM_024902 BI760222 CB128248 BM837569 

    GeneLoc Exon Structure


    Expression
    for DNAJC22 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DNAJC22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DNAJC22 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    Genevestigator expression for DNAJC22

    SOURCE GeneReport for Unigene cluster: Hs.659300
        SABiosciences Custom PCR Arrays for DNAJC22
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC22

    Orthologs
    for DNAJC22 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DNAJC22 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dnajc221 , 5 DnaJ (Hsp40) homolog, subfamily C, member 221, 5 85.05(n)1
    82.6(a)1    		   15 (55.87 cM)5
    727781  NM_176835.21  NP_789805.11 
     990931705 
    chicken
    (Gallus gallus)    		 Aves DNAJC221 DnaJ (Hsp40) homolog, subfamily C, member 22 62.59(n)
    56.12(a)    		   430880  XM_428430.3  XP_428430.3 
    lizard
    (Anolis carolinensis)    		 Reptilia DNAJC226
    		 --
    		 61(a)
    		 1 ↔ 1
    		 GL343198.1(2212158-2222482)
    zebrafish
    (Danio rerio)    		 Actinopterygii dnajc221 DnaJ (Hsp40) homolog, subfamily C, member 22 57.24(n)
    52.58(a)    		   796659  XM_001335344.2  XP_001335380.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta wus1 wurst 45.67(n)
    34.09(a)    		   32683  NM_132952.2  NP_573180.1 


    ENSEMBL Gene Tree for DNAJC22 (if available)
    TreeFam Gene Tree for DNAJC22 (if available) 

    Paralogs
    for DNAJC22 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for DNAJC22 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/116 NCBI SNPs in DNAJC22 are shown (see all 116)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1825755791,2
    		--49739072(+) CAGGGC/TCTCCC 1 -- us2k10--------
    rs1154312591,2
    		F,--49739085(+) TCCCCC/GGCTCA 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1489946271,2
    		--49739372(+) GGCTGA/GGACAC 1 -- us2k10--------
    rs1853712641,2
    		--49739585(+) TGGACC/TCCACC 1 -- us2k10--------
    rs1894851671,2
    		--49739586(+) GGACCA/CCACCT 1 -- us2k10--------
    rs122976581,2
    		C,F,H--49739661(+) CGATGC/ATGAGA 1 -- us2k13Minor allele frequency- A:0.01NS NA 230
    rs1807463711,2
    		--49739735(+) GGGTTC/TTTTGG 1 -- us2k10--------
    rs740890311,2
    		C,--49739772(+) TGCGGG/ATAAAT 1 -- us2k12Minor allele frequency- A:0.15WA 120
    rs1437697461,2
    		--49739905(+) AGTGAC/GGGCCC 1 -- us2k10--------
    rs1481379861,2
    		--49740074(+) TCTCCA/CGGCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DNAJC22 (49740700 - 49751309 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DNAJC22: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNAJC22
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAJC22

    Disorders / Diseases
    for DNAJC22 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DNAJC22 for disorders           About GeneDecksing

    1 disease for DNAJC22:    About MalaCards
    lichen planus


    Export disorders for DNAJC22 gene to outside databases

    Publications
    for DNAJC22 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DNAJC22 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with DNAJC22)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Wurst is essential for airway clearance and respiratory-tube size control. (PubMed id 17558392)1, 3 Behr M....Hoch M. (2007)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for DNAJC22 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DNAJC22 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79962 HGNC: 25802 AceView: FLJ13236 Ensembl:ENSG00000178401 euGenes: HUgn79962
    ECgene: DNAJC22 H-InvDB: DNAJC22

    Other Databases showing DNAJC22 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DNAJC22 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DNAJC22 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DNAJC22 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DNAJC22 gene:
    Search GeneIP for patents involving DNAJC22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for DNAJC22 gene

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    Advanced Cell Diagnostics
    About This Section

     
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