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DNAJC21 Gene

protein-coding   GIFtS: 47
GCID: GC05P034929

DnaJ (Hsp40) Homolog, Subfamily C, Member 21

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DnaJ (Hsp40) Homolog, Subfamily C, Member 211 2     JJJ12
DnaJ Homolog Subfamily A Member 52 3     DnaJ Homolog Subfamily C Member 212
DNAJA52 3     DnaJ Homology Subfamily A Member 52
JJJ1 DnaJ Domain Protein Homolog (S. Cerevisiae)1     JJJ1 DnaJ Domain Protein Homolog2
GS32     Protein GS33

External Ids:    HGNC: 270301   Entrez Gene: 1342182   Ensembl: ENSG000001687247   UniProtKB: Q5F1R63   

Export aliases for DNAJC21 gene to outside databases

Previous GC identifer: GC05P034965


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DNAJC21 Gene:
DNAJC21 (DnaJ (Hsp40) homolog, subfamily C, member 21) is a protein-coding gene. Diseases associated with DNAJC21 include breast and colorectal cancer, and pancreatic cancer. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot: DJC21_HUMAN, Q5F1R6
Function: May act as a co-chaperone for HSP70




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_006576.17  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAJC21 gene promoter:
         RORalpha1   GR   Pax-3   AML1a   FOXD3   GR-alpha   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJC21 promoter sequence
   Search Chromatin IP Primers for DNAJC21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAJC21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.2   Ensembl cytogenetic band:  5p13.2   HGNC cytogenetic band: 5p13-p12

DNAJC21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJC21 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P034929:  view genomic region     (about GC identifiers)

Start:
34,929,698 bp from pter      End:
34,959,069 bp from pter
Size:
29,372 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DJC21_HUMAN, Q5F1R6 (See protein sequence)
Recommended Name: DnaJ homolog subfamily C member 21  
Size: 531 amino acids; 62028 Da
Sequence caution: Sequence=AAH65745.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAI07578.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAC87112.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q3B7J9 Q6P086 Q6ZS43 Q86VC6
Alternative splicing: 3 isoforms:  Q5F1R6-1   Q5F1R6-2   Q5F1R6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DNAJC21: NX_Q5F1R6

Explore proteomics data for DNAJC21 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys29
  • Modification sites at PhosphoSitePlus

  • See DNAJC21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001012339.2  NP_919259.3  

    ENSEMBL proteins: 
     ENSP00000343728   ENSP00000371451   ENSP00000306289  

    DNAJC21 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DNAJC21
    GenScript Custom Purified and Recombinant Proteins Services for DNAJC21
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DNAJC21

    DNAJC21 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DNAJC21
    Novus Biologicals DNAJC21 Antibodies
    Abcam antibodies for DNAJC21
    Cloud-Clone Corp. Antibodies for DNAJC21
    Search ThermoFisher Antibodies for DNAJC21
    Search LSBio for Antibodies for DNAJC21

    DNAJC21 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DNAJC21
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DNAJC21
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DNAJC21
    Cloud-Clone Corp. CLIAs for DNAJC21


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    Selected InterPro protein domains (see all 6):
     IPR003604 Znf_U1
     IPR015880 Znf_C2H2-like
     IPR001623 DnaJ_domain
     IPR018253 DnaJ_domain_CS
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q5F1R6

    ProtoNet protein and cluster: Q5F1R6

    1 Blocks protein domain: IPB003604 Zn-finger

    UniProtKB/Swiss-Prot: DJC21_HUMAN, Q5F1R6
    Similarity: Contains 2 C2H2-type zinc fingers
    Similarity: Contains 1 J domain


    DNAJC21 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DJC21_HUMAN, Q5F1R6
    Function: May act as a co-chaperone for HSP70

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003676nucleic acid binding ----
    GO:0005515protein binding IPI17500595
    GO:0008270zinc ion binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    DNAJC21 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNAJC21
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DNAJC21

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DNAJC21
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DNAJC21

    miRNA
    Products:
        
    miRTarBase miRNAs that target DNAJC21:
    hsa-mir-92a-3p (MIRT049403)

    Block miRNA regulation of human, mouse, rat DNAJC21 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAJC21 (see all 50):
    hsa-miR-3678-3p hsa-miR-607 hsa-miR-3152-3p hsa-miR-4328 hsa-miR-4275 hsa-miR-877* hsa-miR-183* hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidDNAJC21 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DNAJC21
    Predesigned siRNA for gene silencing in human, mouse, rat DNAJC21

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DNAJC21

    Clone
    Products:
         
    OriGene clones in human, mouse for DNAJC21 (see all 11)
    OriGene ORF clones in mouse, rat for DNAJC21
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DNAJC21 (NM_001012339)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJC21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC21

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DNAJC21
    Browse ESI BIO Cell Lines and PureStem Progenitors for DNAJC21 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC21


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005840ribosome NAS16952052

    DNAJC21 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including DNAJC21: 
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DNAJC21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNAJC21 (Q5F1R61, 3 ENSP000003714514) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MTERFQ995511, 3EBI-2654581,EBI-2690033 I2D: score=1 
    VAV2P527353, ENSP000003609164I2D: score=1 STRING: ENSP00000360916
    NMD3ENSP000003075254STRING: ENSP00000307525
    PA2G4ENSP000003028864STRING: ENSP00000302886
    DNAJC2ENSP000003685654STRING: ENSP00000368565
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding NAS16952052

    DNAJC21 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNAJC21 (DJC21)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DNAJC21 gene (2 alternative transcripts): 
    NM_001012339.2  NM_194283.3  

    Unigene Cluster for DNAJC21:

    DnaJ (Hsp40) homolog, subfamily C, member 21
    Hs.131887  [show with all ESTs]
    Unigene Representative Sequence: NM_194283
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342382 ENST00000382021(uc003jjb.3 uc003jjc.3) ENST00000514237
    ENST00000512136(uc003jjd.3) ENST00000506762 ENST00000509626 ENST00000303525(uc010iuu.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DNAJC21 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAJC21 (see all 50):
    hsa-miR-3678-3p hsa-miR-607 hsa-miR-3152-3p hsa-miR-4328 hsa-miR-4275 hsa-miR-877* hsa-miR-183* hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidDNAJC21 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DNAJC21
    Predesigned siRNA for gene silencing in human, mouse, rat DNAJC21
    Clone
    Products:
         
    OriGene clones in human, mouse for DNAJC21 (see all 11)
    OriGene ORF clones in mouse, rat for DNAJC21
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DNAJC21 (NM_001012339)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJC21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC21
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJC21
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAJC21
      QuantiTect SYBR Green Assays in human, mouse, rat DNAJC21
      QuantiFast Probe-based Assays in human, mouse, rat DNAJC21

    Additional mRNA sequence: 

    AK127749.1 AY177688.1 AY258422.1 BC050472.1 BC065745.1 BC107577.1 BX648765.1 

    8 DOTS entries:

    DT.91730041  DT.436869  DT.91701078  DT.100652930  DT.100690758  DT.109905  DT.91709950  DT.91701084 

    Selected AceView cDNA sequences (see all 125):

    AA554383 CK904822 AA928145 BG390661 BI257314 CF145605 AW009730 BX114426 
    AA862952 BM673160 BC050472 AI362795 AA453437 AI278701 BQ959338 BI087286 
    BM765283 AL047005 BU675709 AA159825 AA724051 AA384826 BE878503 BQ012803 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNAJC21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGACAGAAA
    DNAJC21 Expression
    About this image

    DNAJC21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAJC21 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.131887

    UniProtKB/Swiss-Prot: DJC21_HUMAN, Q5F1R6
    Tissue specificity: Brain, placenta, kidney and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Array including DNAJC21: 
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJC21
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAJC21
    QuantiTect SYBR Green Assays in human, mouse, rat DNAJC21
    QuantiFast Probe-based Assays in human, mouse, rat DNAJC21
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DNAJC21 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnajc211 , 5 DnaJ (Hsp40) homolog, subfamily C, member 211, 5 85.79(n)1
    84.72(a)1
      15 (5.35 cM)5
    782441  NM_030046.21  NP_084322.21 
     104467565 
    chicken
    (Gallus gallus)
    Aves DNAJC211 DnaJ (Hsp40) homolog, subfamily C, member 21 71.79(n)
    70.92(a)
      427434  XM_425006.4  XP_425006.2 
    lizard
    (Anolis carolinensis)
    Reptilia DNAJC216
    DnaJ (Hsp40) homolog, subfamily C, member 21
    70(a)
    1 ↔ 1
    GL343241.1(2014273-2028229)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.217442 Xenopus laevis transcribed sequence with weak similarity more 75.32(n)    48048250 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa66c022 wufa66c02 76.49(n)   336984  BC056785.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG27901 CG2790 53.71(n)
    49.14(a)
      37992  NM_138142.4  NP_611986.2 
    worm
    (Caenorhabditis elegans)
    Secernentea dnj-171 dnj-17 54.87(n)
    46.49(a)
      176761  NM_067358.3  NP_499759.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes JJJ1(YNL227C)4
    JJJ11
    Co-chaperone that stimulates the ATPase activity of more4
    JJJ11
    51.46(n)1
    42.81(a)1
      14(222431-220659)4
    8554951, 4  NP_014172.11, 4 


    ENSEMBL Gene Tree for DNAJC21 (if available)
    TreeFam Gene Tree for DNAJC21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNAJC21 gene
    1 SIMAP similar gene for DNAJC21 using alignment to 1 protein entry:     DJC21_HUMAN:
    DNAJB3

    DNAJC21 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNAJC21 (see all 624)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361634
    A breast cancer sample4--see VAR_0361632 D N mis40--------
    rs1126214201,2
    C--34927753(+) TCCTTG/ATATCT 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1425323011,2
    --34927844(+) AAGGGC/TACCAG 2 -- us2k10--------
    rs798366601,2
    C,F--34927880(+) ATTAGC/TGGCAG 2 -- us2k14Minor allele frequency- T:0.06NA EA 244
    rs1928087971,2
    --34928008(+) CCCACA/GCCACC 2 -- us2k10--------
    rs1155445661,2
    F--34928018(+) CATGCC/TTGGCT 2 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1119125671,2
    C,F--34928052(+) GTTCTC/TGCTAT 2 -- us2k13Minor allele frequency- T:0.08NA 124
    rs1509306081,2
    --34928079(+) TTGAAC/TTCTTG 2 -- us2k10--------
    rs1394384641,2
    --34928107(+) TGCCTC/TGGCTT 2 -- us2k10--------
    rs1857231651,2
    --34928236(+) TCTTAA/CTTCAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DNAJC21 (34929698 - 34959069 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DNAJC21:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv28154CNV Loss19812545
    nsv4789CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAJC21
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAJC21

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    5 diseases for DNAJC21:    
    About MalaCards
    breast and colorectal cancer    pancreatic cancer    pancreatitis    malaria
    colorectal cancer


    DNAJC21 for disorders           About GeneDecksing


    Export disorders for DNAJC21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNAJC21 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with DNAJC21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel human cDNA encoding a J- domain protein (DNAJA5) from the fetal brain. (PubMed id 15067379)1, 2, 3 Chen J.... Mao Y. (Int. J. Mol. Med. 2004)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker. (PubMed id 22566498)1 Turner S.T....Boerwinkle E. (Hypertension 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 134218 HGNC: 27030 AceView: LOC134218 Ensembl:ENSG00000168724 euGenes: HUgn134218
    ECgene: DNAJC21 H-InvDB: DNAJC21

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DNAJC21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNAJC21 gene:
    Search GeneIP for patents involving DNAJC21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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