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Aliases for DNAJC21 Gene

Aliases for DNAJC21 Gene

  • DnaJ (Hsp40) Homolog, Subfamily C, Member 21 2 3
  • DnaJ Homolog Subfamily A Member 5 3 4
  • DNAJA5 3 4
  • JJJ1 DnaJ Domain Protein Homolog (S. Cerevisiae) 2
  • DnaJ Homology Subfamily A Member 5 3
  • JJJ1 DnaJ Domain Protein Homolog 3
  • Protein GS3 4
  • JJJ1 3
  • GS3 3

External Ids for DNAJC21 Gene

Previous GeneCards Identifiers for DNAJC21 Gene

  • GC05P034965

Summaries for DNAJC21 Gene

GeneCards Summary for DNAJC21 Gene

DNAJC21 (DnaJ (Hsp40) Homolog, Subfamily C, Member 21) is a Protein Coding gene. Diseases associated with DNAJC21 include hymenolepiasis. GO annotations related to this gene include nucleic acid binding and poly(A) RNA binding.

UniProtKB/Swiss-Prot for DNAJC21 Gene

  • May act as a co-chaperone for HSP70

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC21 Gene

Genomics for DNAJC21 Gene

Regulatory Elements for DNAJC21 Gene

Genomic Location for DNAJC21 Gene

Chromosome:
5
Start:
34,929,593 bp from pter
End:
34,958,964 bp from pter
Size:
29,372 bases
Orientation:
Plus strand

Genomic View for DNAJC21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJC21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC21 Gene

Proteins for DNAJC21 Gene

  • Protein details for DNAJC21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5F1R6-DJC21_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 21
    Protein Accession:
    Q5F1R6
    Secondary Accessions:
    • Q3B7J9
    • Q6P086
    • Q6ZS43
    • Q86VC6

    Protein attributes for DNAJC21 Gene

    Size:
    531 amino acids
    Molecular mass:
    62028 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH65745.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI07578.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAC87112.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAJC21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJC21 Gene

Proteomics data for DNAJC21 Gene at MOPED

Post-translational modifications for DNAJC21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJC21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJC21 Gene

Domains & Families for DNAJC21 Gene

Gene Families for DNAJC21 Gene

Protein Domains for DNAJC21 Gene

Suggested Antigen Peptide Sequences for DNAJC21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5F1R6

UniProtKB/Swiss-Prot:

DJC21_HUMAN :
  • Contains 1 J domain.
  • Contains 2 C2H2-type zinc fingers.
Domain:
  • Contains 1 J domain.
Similarity:
  • Contains 2 C2H2-type zinc fingers.
genes like me logo Genes that share domains with DNAJC21: view

Function for DNAJC21 Gene

Molecular function for DNAJC21 Gene

UniProtKB/Swiss-Prot Function:
May act as a co-chaperone for HSP70

Gene Ontology (GO) - Molecular Function for DNAJC21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 17500595
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with DNAJC21: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJC21

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJC21 Gene

Localization for DNAJC21 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJC21 Gene COMPARTMENTS Subcellular localization image for DNAJC21 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for DNAJC21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005840 ribosome NAS 16952052
genes like me logo Genes that share ontologies with DNAJC21: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DNAJC21 Gene

Pathways & Interactions for DNAJC21 Gene

SuperPathways for DNAJC21 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DNAJC21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding NAS 16952052
genes like me logo Genes that share ontologies with DNAJC21: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJC21 Gene

Drugs & Compounds for DNAJC21 Gene

No Compound Related Data Available

Transcripts for DNAJC21 Gene

Unigene Clusters for DNAJC21 Gene

DnaJ (Hsp40) homolog, subfamily C, member 21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJC21

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC21 Gene

No ASD Table

Relevant External Links for DNAJC21 Gene

GeneLoc Exon Structure for
DNAJC21
ECgene alternative splicing isoforms for
DNAJC21

Expression for DNAJC21 Gene

mRNA expression in normal human tissues for DNAJC21 Gene

Protein differential expression in normal tissues from HIPED for DNAJC21 Gene

This gene is overexpressed in Lung (54.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJC21 Gene



SOURCE GeneReport for Unigene cluster for DNAJC21 Gene Hs.131887

mRNA Expression by UniProt/SwissProt for DNAJC21 Gene

Q5F1R6-DJC21_HUMAN
Tissue specificity: Brain, placenta, kidney and pancreas
genes like me logo Genes that share expression patterns with DNAJC21: view

Protein tissue co-expression partners for DNAJC21 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DNAJC21 Gene

Orthologs for DNAJC21 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNAJC21 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNAJC21 35
  • 88.89 (n)
  • 90.21 (a)
-- 36
  • 81 (a)
OneToMany
DNAJC21 36
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia DNAJC21 35
  • 90.58 (n)
  • 91.53 (a)
DNAJC21 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajc21 35
  • 85.79 (n)
  • 84.72 (a)
Dnajc21 16
Dnajc21 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DNAJC21 35
  • 99.44 (n)
  • 99.44 (a)
DNAJC21 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajc21 35
  • 84.24 (n)
  • 77.21 (a)
oppossum
(Monodelphis domestica)
Mammalia DNAJC21 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC21 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJC21 35
  • 71.79 (n)
  • 70.92 (a)
DNAJC21 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJC21 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc21 35
  • 72.19 (n)
  • 75.4 (a)
Str.6320 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.21744 35
zebrafish
(Danio rerio)
Actinopterygii dnajc21 35
  • 63.07 (n)
  • 64.96 (a)
wufa66c02 35
dnajc21 36
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009943 35
  • 54.41 (n)
  • 50.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2790 35
  • 53.71 (n)
  • 49.14 (a)
CG2790 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dnj-17 35
  • 54.87 (n)
  • 46.49 (a)
dnj-17 36
  • 37 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL194C 35
  • 49.14 (n)
  • 38.86 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D19602g 35
  • 50.1 (n)
  • 41.3 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes JJJ1 35
  • 51.46 (n)
  • 42.81 (a)
JJJ1 36
  • 29 (a)
OneToOne
JJJ1 38
Species with no ortholog for DNAJC21:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC21 Gene

ENSEMBL:
Gene Tree for DNAJC21 (if available)
TreeFam:
Gene Tree for DNAJC21 (if available)

Paralogs for DNAJC21 Gene

(1) SIMAP similar genes for DNAJC21 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DNAJC21: view

No data available for Paralogs for DNAJC21 Gene

Variants for DNAJC21 Gene

Sequence variations from dbSNP and Humsavar for DNAJC21 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_036163 A breast cancer sample
VAR_061145 -

Structural Variations from Database of Genomic Variants (DGV) for DNAJC21 Gene

Variant ID Type Subtype PubMed ID
nsv4789 CNV Loss 18451855
esv28154 CNV Loss 19812545

Variation tolerance for DNAJC21 Gene

Residual Variation Intolerance Score: 49.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC21 Gene

HapMap Linkage Disequilibrium report
DNAJC21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC21 Gene

Disorders for DNAJC21 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DNAJC21 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hymenolepiasis
  • dwarf tapeworm infection
- elite association

Relevant External Links for DNAJC21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJC21
genes like me logo Genes that share disorders with DNAJC21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNAJC21 Gene

Publications for DNAJC21 Gene

  1. Cloning and characterization of a novel human cDNA encoding a J- domain protein (DNAJA5) from the fetal brain. (PMID: 15067379) Chen J. … Mao Y. (Int. J. Mol. Med. 2004) 2 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  3. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 67
  4. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 67
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67

Products for DNAJC21 Gene

Sources for DNAJC21 Gene

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