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Aliases for DNAJC21 Gene

Aliases for DNAJC21 Gene

  • DnaJ (Hsp40) Homolog, Subfamily C, Member 21 2 3
  • DnaJ Homolog Subfamily A Member 5 3 4
  • DNAJA5 3 4
  • JJJ1 DnaJ Domain Protein Homolog (S. Cerevisiae) 2
  • DnaJ Homology Subfamily A Member 5 3
  • DnaJ Homolog Subfamily C Member 21 3
  • JJJ1 DnaJ Domain Protein Homolog 3
  • Protein GS3 4
  • JJJ1 3
  • GS3 3

External Ids for DNAJC21 Gene

Previous GeneCards Identifiers for DNAJC21 Gene

  • GC05P034965

Summaries for DNAJC21 Gene

GeneCards Summary for DNAJC21 Gene

DNAJC21 (DnaJ (Hsp40) Homolog, Subfamily C, Member 21) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for DNAJC21 Gene

  • May act as a co-chaperone for HSP70

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC21 Gene

Genomics for DNAJC21 Gene

Regulatory Elements for DNAJC21 Gene

Genomic Location for DNAJC21 Gene

Start:
34,929,593 bp from pter
End:
34,958,964 bp from pter
Size:
29,372 bases
Orientation:
Plus strand

Genomic View for DNAJC21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJC21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC21 Gene

Proteins for DNAJC21 Gene

  • Protein details for DNAJC21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5F1R6-DJC21_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 21
    Protein Accession:
    Q5F1R6
    Secondary Accessions:
    • Q3B7J9
    • Q6P086
    • Q6ZS43
    • Q86VC6

    Protein attributes for DNAJC21 Gene

    Size:
    531 amino acids
    Molecular mass:
    62028 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH65745.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI07578.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAC87112.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAJC21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJC21 Gene

Proteomics data for DNAJC21 Gene at MOPED

Post-translational modifications for DNAJC21 Gene

  • Ubiquitination at Lys29
  • Modification sites at PhosphoSitePlus

Other Protein References for DNAJC21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJC21 Gene

Domains for DNAJC21 Gene

Gene Families for DNAJC21 Gene

HGNC:
  • DNAJ :Heat shock proteins / DNAJ (HSP40)

Protein Domains for DNAJC21 Gene

Suggested Antigen Peptide Sequences for DNAJC21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5F1R6

UniProtKB/Swiss-Prot:

DJC21_HUMAN :
  • Q5F1R6
Domain:
  • Contains 1 J domain.
Similarity:
  • Contains 2 C2H2-type zinc fingers.
genes like me logo Genes that share domains with DNAJC21: view

Function for DNAJC21 Gene

Molecular function for DNAJC21 Gene

UniProtKB/Swiss-Prot Function: May act as a co-chaperone for HSP70

Gene Ontology (GO) - Molecular Function for DNAJC21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 17500595
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with DNAJC21: view

Animal Model Products

CRISPR Products

miRNA for DNAJC21 Gene

miRTarBase miRNAs that target DNAJC21

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJC21

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DNAJC21 Gene

Localization for DNAJC21 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJC21 Gene COMPARTMENTS Subcellular localization image for DNAJC21 gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for DNAJC21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005840 ribosome NAS 16952052
genes like me logo Genes that share ontologies with DNAJC21: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DNAJC21 Gene

Pathways for DNAJC21 Gene

SuperPathways for DNAJC21 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DNAJC21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding NAS 16952052
genes like me logo Genes that share ontologies with DNAJC21: view

No data available for Pathways by source for DNAJC21 Gene

Transcripts for DNAJC21 Gene

Unigene Clusters for DNAJC21 Gene

DnaJ (Hsp40) homolog, subfamily C, member 21:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJC21

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DNAJC21

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC21 Gene

No ASD Table

Relevant External Links for DNAJC21 Gene

GeneLoc Exon Structure for
DNAJC21
ECgene alternative splicing isoforms for
DNAJC21

Expression for DNAJC21 Gene

mRNA expression in normal human tissues for DNAJC21 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJC21 Gene

SOURCE GeneReport for Unigene cluster for DNAJC21 Gene Hs.131887

mRNA Expression by UniProt/SwissProt for DNAJC21 Gene

Q5F1R6-DJC21_HUMAN
Tissue specificity: Brain, placenta, kidney and pancreas
genes like me logo Genes that share expressions with DNAJC21: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DNAJC21 Gene

Orthologs for DNAJC21 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNAJC21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC21 35
  • 99.44 (n)
  • 99.44 (a)
DNAJC21 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 81 (a)
OneToMany
DNAJC21 35
  • 88.89 (n)
  • 90.21 (a)
DNAJC21 36
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia DNAJC21 35
  • 90.58 (n)
  • 91.53 (a)
DNAJC21 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajc21 35
  • 85.79 (n)
  • 84.72 (a)
Dnajc21 16
Dnajc21 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNAJC21 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC21 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajc21 35
  • 84.24 (n)
  • 77.21 (a)
chicken
(Gallus gallus)
Aves DNAJC21 35
  • 71.79 (n)
  • 70.92 (a)
DNAJC21 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJC21 36
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21744 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc21 35
  • 72.19 (n)
  • 75.4 (a)
Str.6320 35
zebrafish
(Danio rerio)
Actinopterygii dnajc21 35
  • 63.07 (n)
  • 64.96 (a)
dnajc21 36
  • 63 (a)
OneToOne
wufa66c02 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009943 35
  • 54.41 (n)
  • 50.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2790 35
  • 53.71 (n)
  • 49.14 (a)
CG2790 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dnj-17 35
  • 54.87 (n)
  • 46.49 (a)
dnj-17 36
  • 37 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL194C 35
  • 49.14 (n)
  • 38.86 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes JJJ1 35
  • 51.46 (n)
  • 42.81 (a)
JJJ1 36
  • 29 (a)
OneToOne
JJJ1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D19602g 35
  • 50.1 (n)
  • 41.3 (a)
Species with no ortholog for DNAJC21:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC21 Gene

ENSEMBL:
Gene Tree for DNAJC21 (if available)
TreeFam:
Gene Tree for DNAJC21 (if available)

Paralogs for DNAJC21 Gene

Selected SIMAP similar genes for DNAJC21 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DNAJC21: view

No data available for Paralogs for DNAJC21 Gene

Variants for DNAJC21 Gene

Sequence variations from dbSNP and Humsavar for DNAJC21 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs14966 -- 34,954,978(-) GCCAA(A/T)AAACA utr-variant-3-prime
rs27160 -- 34,930,096(-) AGGGC(A/G)GAGCG intron-variant
rs27161 -- 34,928,611(-) GGGTT(G/T)TATTT upstream-variant-2KB
rs27162 -- 34,928,409(-) TCCCT(G/T)TTTTC upstream-variant-2KB
rs27163 -- 34,928,242(-) ACGGA(A/C)AGGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DNAJC21 Gene

Variant ID Type Subtype PubMed ID
nsv4789 CNV Loss 18451855
esv28154 CNV Loss 19812545

Relevant External Links for DNAJC21 Gene

HapMap Linkage Disequilibrium report
DNAJC21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC21 Gene

Disorders for DNAJC21 Gene

No disorders were found for DNAJC21 Gene.

No data available for UniProtKB/Swiss-Prot for DNAJC21 Gene

Publications for DNAJC21 Gene

  1. Cloning and characterization of a novel human cDNA encoding a J- domain protein (DNAJA5) from the fetal brain. (PMID: 15067379) Chen J. … Mao Y. (Int. J. Mol. Med. 2004) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. Huntingtin interacting proteins are genetic modifiers of neurodegeneration. (PMID: 17500595) Kaltenbach L.S. … Hughes R.E. (PLoS Genet. 2007) 3

Products for DNAJC21 Gene

Sources for DNAJC21 Gene

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