DNAJC21 Gene
protein-coding GIFtS: 45
GCID: GC05P034965
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DnaJ (Hsp40) homolog, subfamily C, member 21
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Aliases
for DNAJC21 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DnaJ (Hsp40) Homolog, Subfamily C, Member 211 2 | | DnaJ Homolog Subfamily C Member 212 | | DNAJA51 2 3 | | DnaJ Homology Subfamily A Member 52 | | GS31 2 | | JJJ1 DnaJ Domain Protein Homolog2 | | JJJ11 2 | | Protein GS33 | | DnaJ Homolog Subfamily A Member 52 3 | | |
Export aliases for DNAJC21 gene to outside databases |
Summaries
for DNAJC21 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: DJC21_HUMAN, Q5F1R6Function: May act as a co-chaperone for HSP70
|
Genomic Views
for DNAJC21 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006576.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DNAJC21 gene promoter:
RORalpha1 GR Pax-3 AML1a FOXD3 GR-alpha Evi-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DNAJC21
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJC21 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5p13.2 Ensembl cytogenetic band: 5p13.2 HGNC cytogenetic band: 5p13-p12DNAJC21 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P034965: view genomic region
(about GC identifiers)
Start:
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34,929,698 bp from pter |
End:
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34,959,069 bp from pter |
Size:
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29,372 bases |
Orientation:
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plus strand |
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Proteins
for DNAJC21 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DJC21_HUMAN, Q5F1R6 (See
protein sequence)Recommended Name: DnaJ homolog subfamily C member 21 Size: 531 amino acids; 62028 Da
Sequence caution: Sequence=AAH65745.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence; Sequence=AAI07578.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;Sequence=BAC87112.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q3B7J9 Q6P086 Q6ZS43 Q86VC6Alternative splicing: 3 isoforms: Q5F1R6-1 Q5F1R6-2 Q5F1R6-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DNAJC21: NX_Q5F1R6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5F1R6
DNAJC21 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001012339.2 NP_919259.3
ENSEMBL proteins: ENSP00000343728 ENSP00000371451 ENSP00000306289
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
DNAJC21 for ontologies About GeneDecksing
DNAJC21 Antibody Products:
Assay Products for DNAJC21: |
Protein
Domains /
Families
for DNAJC21 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DNAJC21 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q5F1R6ProtoNet protein and cluster: Q5F1R6 1 Blocks protein family: IPB003604 Zn-finger
UniProtKB/Swiss-Prot: DJC21_HUMAN, Q5F1R6Similarity: Contains 2 C2H2-type zinc fingersSimilarity: Contains 1 J domain |
Function
for DNAJC21 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DJC21_HUMAN, Q5F1R6Function: May act as a co-chaperone for HSP70
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC21 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC21 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for DNAJC21 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC21 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC21 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
DNAJC21 for ontologies About GeneDecksing
|
Pathways & Interactions
for DNAJC21 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNAJC21
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/13 Interacting proteins for DNAJC21 (Q5F1R61, 3 ENSP000003714514) via UniProtKB, MINT, STRING, and/or I2D (see all 13)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
DNAJC21 for ontologies About GeneDecksing
|
Drugs & Compounds
for DNAJC21 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DNAJC21
Search CenterWatch for drugs/clinical trials and news about DNAJC21 / DJC21
|
Transcripts
for DNAJC21 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DNAJC21 gene (2 alternative transcripts): NM_001012339.2 NM_194283.3 Unigene Cluster for DNAJC21: DnaJ (Hsp40) homolog, subfamily C, member 21 Hs.131887 [show with all ESTs]Unigene Representative Sequence: NM_1942837 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000342382 ENST00000382021(uc003jjb.3 uc003jjc.3) ENST00000514237
ENST00000512136(uc003jjd.3) ENST00000506762 ENST00000509626 ENST00000303525(uc010iuu.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC21 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC21 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): DNAJC21 (NM_001012339) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DNAJC21 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC21 |
Additional cDNA sequence: AK127749.1 AY177688.1 AY258422.1 BC050472.1 BC065745.1 BC107577.1 BX648765.1 8 DOTS entries: DT.91730041 DT.436869 DT.91701078 DT.100652930 DT.100690758 DT.109905 DT.91709950 DT.91701084 24/125 AceView cDNA sequences (see all 125): CR610463 BQ012803 BE878503 AA384826 AA383435 AI278701 BX091263 BX114426 BC050472 AA724051 AI922884 BU675709 AA928145 AA554383 BG390661 CK904822 BQ959338 BM055163 BM765283 AL047005 BM673160 AA159825 AA862952 AI362795
GeneLoc Exon Structure
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Expression
for DNAJC21 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DNAJC21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGACAGAAA
About this image
See DNAJC21 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DNAJC21
SOURCE GeneReport for Unigene cluster: Hs.131887
UniProtKB/Swiss-Prot: DJC21_HUMAN, Q5F1R6Tissue specificity: Brain, placenta, kidney and pancreas
SABiosciences Expression via Pathway-Focused PCR Array including DNAJC21:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNAJC21
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DNAJC21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAJC21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAJC21 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC21 |
Orthologs
for DNAJC21 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DNAJC21 gene from 10/31 species (see all 31) About this table
ENSEMBL Gene Tree for DNAJC21 (if available)
TreeFam Gene Tree for DNAJC21 (if available) |
Paralogs
for DNAJC21 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DNAJC21 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for DNAJC21 (34929698 - 34959069 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DNAJC21
1 CNV: 69053 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNAJC21 |
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Disorders
/ Diseases
for DNAJC21 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DNAJC21 for disorders About GeneDecksing
3  diseases for DNAJC21: About MalaCardsmalaria pancreatic cancer pancreatitis
Export disorders for DNAJC21 gene to outside databases
|
Publications
for DNAJC21 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DNAJC21 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with DNAJC21) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of a novel human cDNA encoding a J- domain protein (DNAJA5) from the fetal brain. (PubMed id 15067379)1, 2, 3 Chen J.... Mao Y. (2004)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker. (PubMed id 22566498)1 Turner S.T....Boerwinkle E. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
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External Searches for DNAJC21 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing DNAJC21 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DNAJC21 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DNAJC21 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DNAJC21 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for DNAJC21 gene:
Search GeneIP for patents involving DNAJC21
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DNAJC21 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DNAJC21 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNAJC21 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNAJC21 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DNAJC21 | | OriGene 3'-UTR Clone for DNAJC21 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC21 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC21 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DNAJC21 | | OriGene Custom Protein Services for DNAJC21 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DNAJC21 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNAJC21 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJC21 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNAJC21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAJC21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAJC21 |
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 | | | DNAJC21 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC21 |
|  |  |  | | | | Search ThermoFisher Antibodies for DNAJC21 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC21 |
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