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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DNAJC2 Gene

protein-coding GIFtS: 49
GCID: GC07M102952

DnaJ (Hsp40) homolog, subfamily C, member 2

(Previous name: zuotin related factor 1 )
(Previous symbol: ZRF1)

Explore 5 diseases affiliated with
DNAJC2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
DnaJ (Hsp40) Homolog, Subfamily C, Member 2¹ ²		Zuotin Related Factor 1¹ ²
MPP11¹ ² ³ ⁵		Zuotin-Related Factor 1² ³
ZRF1¹ ² ³ ⁵		M-Phase Phosphoprotein 11² ³
MPHOSPH11¹ ² ³		Zuotin¹
ZUO1¹ ²		DnaJ Homolog Subfamily C Member 2²

External Ids:	HGNC: 13192¹	Entrez Gene: 27000²	Ensembl: ENSG00000105821⁷	OMIM: 605502⁵	UniProtKB: Q99543³

Export aliases for DNAJC2 gene to outside databases

Previous GC identifers: GC07M102741 GC07M097315

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DNAJC2:

This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and

a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a

heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains

as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is

upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and

neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode

different protein isoforms have been described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DNJC2_HUMAN, Q99543

Function: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as

a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or

maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of

the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear,

mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A

ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin,

thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'

Gene Wiki entry for DNAJC2 (ZRF1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DNAJC2 gene promoter:
SRF Pax-5 SRF (504 AA) Tal-1beta E47 Max Egr-2 PPAR-gamma1 PPAR-gamma2 c-Myc
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for DNAJC2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJC2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22-q32

DNAJC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJC2 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M102952: view genomic region (about GC identifiers)

Start:	102,952,921 bp from pter	End:	102,985,320 bp from pter
Size:	32,400 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 102,313,287-102,345,686

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DNJC2_HUMAN, Q99543 (See protein sequence)

Recommended Name: DnaJ homolog subfamily C member 2

Size: 621 amino acids; 71996 Da

Subunit: Interacts (via ZRF1-UBD region) with ID1 (By similarity). Component of ribosome-associated complex (RAC), a

heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2

Subcellular location: Nucleus. Cytoplasm, cytosol

Miscellaneous: Constitutes a myeloid leukemia-associated antigen and might be a target for leukemia T-cell therapy

Sequence caution: Sequence=AAI39752.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Sequence=CAA66913.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: A4VCI0 Q9BVX1

Alternative splicing: 2 isoforms: Q99543-1 Q99543-2

Explore the universe of human proteins at neXtProt for DNAJC2: NX_Q99543

Post-translational modifications:

Phosphorylated in M (mitotic) phase¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q99543

DNAJC2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001123359.1 NP_055192.1

ENSEMBL proteins:

ENSP00000249270 ENSP00000368565 ENSP00000412611 ENSP00000399058 ENSP00000368559

ENSP00000406275

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	Uscn Proteins for DNAJC2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	IDA	16002468
GO:0031965	nuclear membrane	IDA	--

DNAJC2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DNAJC2 for domains About GeneDecksing

5 InterPro domains/families:

IPR001623 DnaJ_domain

IPR017884 SANT_dom

IPR018253 DnaJ_domain_CS

IPR001005 SANT/Myb

IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q99543

ProtoNet protein and cluster: Q99543

UniProtKB/Swiss-Prot: DNJC2_HUMAN, Q99543

Domain: The ZRF1-UBD region specifically recognizes and binds H2AK119ub. The ZRF1-UBD region is also involved in

protein-protein interactions with other proteins, suggesting that it may be masked by some regulator, thereby

preventing its association with H2AK119ub

Similarity: Contains 1 J domain

Similarity: Contains 2 SANT domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DNJC2_HUMAN, Q99543

Function: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as

a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or

maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of

the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear,

mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A

ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin,

thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'

Induction: Expression is repressed by CEBPA. Strongly overexpressed in leukemic cells

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In Situ Assay
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Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003682	chromatin binding	IDA	--
GO:0005515	protein binding	--	--
GO:0030544	Hsp70 protein binding	IPI	16002468
GO:0031072	heat shock protein binding	--	--

DNAJC2 for ontologies About GeneDecksing

Animal Models:
1 MGI phenotypic allele

for Dnajc2 (no phenotypes)

DNAJC2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Translational Control

Translational Control

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for DNAJC2

Translational Control

DNAJC2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DNAJC2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/35 Interacting proteins for DNAJC2 (Q99543³ ENSP00000368565⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 35)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST2H2AA3	Q6FI13³, ENSP00000358158⁴	I2D: score=1 STRING: ENSP00000358158
HIST2H2AA4	Q6FI13³	I2D: score=1
RNF2	Q99496³, ENSP00000356480⁴	I2D: score=1 STRING: ENSP00000356480
HSPA14	Q0VDF9³, ENSP00000367623⁴	I2D: score=1 STRING: ENSP00000367623
ATP8B2	P98198³	I2D: score=1

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000085	G2 phase of mitotic cell cycle	IEA	--
GO:0006260	DNA replication	IEA	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006457	protein folding	--	--
GO:0016568	chromatin modification	IEA	--

DNAJC2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DNAJC2
Search CenterWatch for drugs/clinical trials and news about DNAJC2 / DNJC2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DNAJC2 gene (2 alternative transcripts):

NM_001129887.1 NM_014377.1

Unigene Cluster for DNAJC2:

DnaJ (Hsp40) homolog, subfamily C, member 2

Hs.558476 [show with all ESTs]

Unigene Representative Sequence: NM_014377

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000249270 ENST00000475065(uc003vbn.3) ENST00000379263(uc003vbo.3 uc010lix.3 uc003vbp.3 uc003vbq.1)

ENST00000492497 ENST00000464253 ENST00000475090 ENST00000426036 ENST00000454277

ENST00000483637 ENST00000379257 ENST00000412522(uc003vbr.1)

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Additional cDNA sequence:

BC000859.1 BC012376.1 BC046351.1 BC062703.1 BC125057.1 BC139751.1 X98260.1

19 DOTS entries:

DT.102838904 DT.95069522 DT.91641719 DT.101980113 DT.95367662 DT.100888012 DT.101963658 DT.91662981

DT.100888016 DT.101970896 DT.40278493 DT.95227547 DT.456141 DT.97855618 DT.121065832 DT.92008760

DT.92454561 DT.428720 DT.95367648

24/156 AceView cDNA sequences (see all 156):

CB138861 AW612011 BM841190 BU071395 BM978538 CR598046 BC000859 BM554759

CB134063 BC046351 AA543065 BM803636 AI621015 AL832847 AI140595 BM553133

BU622358 BM798599 CR615654 BE672061 AI917680 BM914755 BM969862 CB164507

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC2 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15
SP1:
SP2:
SP3:															-				-
SP4:									-						-
SP5:															-

ECgene alternative splicing isoforms for DNAJC2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DNAJC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAACGATACA

About this image

DNAJC2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Primary Follicle

Primary Oocyte

Female Gametocytes, Germ Cells

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DNAJC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DNAJC2

SOURCE GeneReport for Unigene cluster: Hs.558476

UniProtKB/Swiss-Prot: DNJC2_HUMAN, Q99543

Tissue specificity: Widely expressed

SABiosciences Custom PCR Arrays for DNAJC2

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJC2 gene from 9/35 species (see all 35) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DNAJC2¹	DnaJ (Hsp40) homolog, subfamily C, member 2	82.23(n) 87.88(a)		417717 NM_001199325.1 NP_001186254.1
lizard (Anolis carolinensis)	Reptilia	DNAJC2⁶	--	87(a)	1 ↔ 1	5(95380877-95399546)
African clawed frog (Xenopus laevis)	Amphibia	48043559²	--	78.88(n)		48043559
zebrafish (Danio rerio)	Actinopterygii	Dr.19599²	Danio rerio cDNA clone IMAGE2640354, partial cds	76.31(n)		BC055125.1
fruit fly (Drosophila melanogaster)	Insecta	CG10565¹	CG10565	51.35(n) 48.42(a)		40332 NM_141027.3 NP_649284.1
worm (Caenorhabditis elegans)	Secernentea	dnj-11¹	Protein DNJ-11	51.97(n) 43.91(a)		177419 NM_068605.3 NP_501006.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	ZUO1(YGR285C)⁴ ZUO1¹	Ribosome-associated chaperone, functions in ribosome more⁴ Zuo1p¹	50.22(n)¹ 41.33(a)¹		7(1063153-1061852)⁴ 853202^{1, 4} NP_011801.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G11450¹	DnaJ homolog subfamily C member 2	50.85(n) 41.42(a)		820318 NM_111978.2 NP_187752.2
rice (Oryza sativa)	Liliopsida	Os04g0377932¹	hypothetical protein	45.61(n) 32.95(a)		9268633 NM_001186973.1 NP_001173902.1

ENSEMBL Gene Tree for DNAJC2 (if available)
TreeFam Gene Tree for DNAJC2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DNAJC2 gene

DNAJC1²

1 SIMAP similar gene for DNAJC2 using alignment to 7 protein entries: DNJC2_HUMAN (see all proteins):

DNAJB6

DNAJC2 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for DNAJC2
PGOHUM00000239930 PGOHUM00000243612

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs66502304^1,2	C,	--	102955698(+)	`TTTTA-/GAGGAGTA`	2	--	int¹		0	--	--	--	--
rs182385768^1,2		--	102955801(+)	`TTGAAC/TCATAA`	2	--	int¹		0	--	--	--	--
rs76567953^1,2		--	102955893(+)	`GTACAG/TTTCTC`	2	--	int¹		0	--	--	--	--
rs187424120^1,2		--	102955910(+)	`AAGCAA/GTTATC`	2	--	int¹		0	--	--	--	--
rs116799108^1,2	F,	--	102956154(+)	`GTACGT/ACCAAG`	2	--	int¹		1		WA	118
rs193058291^1,2	C,	--	102956172(+)	`GATACA/GTGGCT`	2	--	int¹		0	--	--	--	--
rs77819714^1,2	C,	--	102956330(+)	`AATGAA/GAAAAA`	2	--	int¹		3		CSA WA	121
rs76592168^1,2	F,	--	102956381(+)	`TGCATA/CAGTTA`	2	--	int¹		1		EA	120
rs200875427^1,2		--	102956432(+)	`AAACTC/TACCAA`	2	--	int¹		0	--	--	--	--
rs61744156^1,2	C,F,	--	102956463(+)	`TTGCCA/GATAAC`	4	I	syn¹		1		NS	46

HapMap Linkage Disequilibrium report for DNAJC2 (102952921 - 102985320 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DNAJC2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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DNAJC2 for disorders           About GeneDecksing

OMIM gene information: 605502    OMIM disorders: --

5 diseases for DNAJC2:    About MalaCards

leukemia myeloid leukemia chronic myeloid leukemia acute myeloid leukemia

malaria

Export disorders for DNAJC2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DNAJC2 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with DNAJC2)

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Identification of novel M phase phosphoproteins by expression cloning. (PubMed id 8885239)^{1, 2, 3} Matsumoto-Taniura N....Westendorf J.M. (1996)
Identification of a novel peptide derived from the M- phase phosphoprotein 11 (MPP11) leukemic antigen recognized by human CD8+ cytot oxic T lymphocytes. (PubMed id 20231810)^{1, 2, 9} Al Qudaihi G....Dermime S. (2010)
The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex. (PubMed id 16002468)^{1, 2, 9} Otto H....Rospert S. (2005)
Characterization of several leukemia-associated antigens inducing humoral immune responses in acute and chronic myeloid leukemia. (PubMed id 12800198)^{1, 2, 9} Greiner J....Schmitt M. (2003)
Transcriptional activation of polycomb-repressed genes by ZRF1. (PubMed id 21179169)^{1, 2} Richly H.... Di Croce L. (2010)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Human Mpp11 J protein: ribosome-tethered molecular chaperones are ubiquitous. (PubMed id 15802566)^{1, 2} Hundley H.A....Craig E.A. (2005)
mRNA expression of leukemia-associated antigens in patients with acute myeloid leukemia for the development of specific immunotherapies. (PubMed id 14696097)^{1, 2} Greiner J....Schmitt M. (2004)
A putative oncogenic role for MPP11 in head and neck squamous cell cancer. (PubMed id 11034098)^{1, 2} Resto V.A....Sidransky D. (2000)
M-phase phosphoprotein 11 is a highly immunogenic tumo r antigen in patients with acute myeloid leukemia. (PubMed id 22433847)¹ Siegel S....Zeis M. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 27000	HGNC: 13192	AceView: ZRF1	Ensembl:ENSG00000105821	euGenes: HUgn27000
ECgene: DNAJC2	H-InvDB: DNAJC2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DNAJC2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DNAJC2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DNAJC2 gene:
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DnaJ (Hsp40) homolog, subfamily C, member 2

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DnaJ (Hsp40) homolog, subfamily C, member 2

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