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Aliases for DNAJC2 Gene

Aliases for DNAJC2 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C2 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 2 2 3
  • M-Phase Phosphoprotein 11 3 4
  • Zuotin-Related Factor 1 3 4
  • MPHOSPH11 3 4
  • MPP11 3 4
  • ZRF1 3 4
  • DnaJ Homolog Subfamily C Member 2 3
  • Zuotin Related Factor 1 2
  • ZUO1 3

External Ids for DNAJC2 Gene

Previous HGNC Symbols for DNAJC2 Gene

  • ZRF1

Previous GeneCards Identifiers for DNAJC2 Gene

  • GC07M102741
  • GC07M102952
  • GC07M097315

Summaries for DNAJC2 Gene

Entrez Gene Summary for DNAJC2 Gene

  • This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for DNAJC2 Gene

DNAJC2 (DnaJ Heat Shock Protein Family (Hsp40) Member C2) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Cellular response to heat stress. GO annotations related to this gene include poly(A) RNA binding and histone binding. An important paralog of this gene is DNAJC1.

UniProtKB/Swiss-Prot for DNAJC2 Gene

  • Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at Lys-119 (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5-GTCAAGC-3.

Gene Wiki entry for DNAJC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC2 Gene

Genomics for DNAJC2 Gene

Regulatory Elements for DNAJC2 Gene

Enhancers for DNAJC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DNAJC2 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DNAJC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DNAJC2 Gene

Chromosome:
7
Start:
103,312,474 bp from pter
End:
103,344,873 bp from pter
Size:
32,400 bases
Orientation:
Minus strand

Genomic View for DNAJC2 Gene

Genes around DNAJC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC2 Gene

Proteins for DNAJC2 Gene

  • Protein details for DNAJC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99543-DNJC2_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 2
    Protein Accession:
    Q99543
    Secondary Accessions:
    • A4VCI0
    • Q9BVX1

    Protein attributes for DNAJC2 Gene

    Size:
    621 amino acids
    Molecular mass:
    71996 Da
    Quaternary structure:
    • Interacts (via ZRF1-UBD region) with ID1 (By similarity). Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.
    Miscellaneous:
    • Constitutes a myeloid leukemia-associated antigen and might be a target for leukemia T-cell therapy.
    SequenceCaution:
    • Sequence=AAI39752.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA66913.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DNAJC2 Gene

    Alternative splice isoforms for DNAJC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJC2 Gene

Post-translational modifications for DNAJC2 Gene

Other Protein References for DNAJC2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DNAJC2 (DNAJC2)
  • Cloud-Clone Corp. Antibodies for DNAJC2

No data available for DME Specific Peptides for DNAJC2 Gene

Domains & Families for DNAJC2 Gene

Protein Domains for DNAJC2 Gene

Suggested Antigen Peptide Sequences for DNAJC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q99543

UniProtKB/Swiss-Prot:

DNJC2_HUMAN :
  • The ZRF1-UBD region specifically recognizes and binds H2AK119ub. The ZRF1-UBD region is also involved in protein-protein interactions with other proteins, suggesting that it may be masked by some regulator, thereby preventing its association with H2AK119ub.
Domain:
  • The ZRF1-UBD region specifically recognizes and binds H2AK119ub. The ZRF1-UBD region is also involved in protein-protein interactions with other proteins, suggesting that it may be masked by some regulator, thereby preventing its association with H2AK119ub.
  • Contains 1 J domain.
  • Contains 2 SANT domains.
genes like me logo Genes that share domains with DNAJC2: view

Function for DNAJC2 Gene

Molecular function for DNAJC2 Gene

UniProtKB/Swiss-Prot Function:
Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at Lys-119 (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5-GTCAAGC-3.
UniProtKB/Swiss-Prot Induction:
Expression is repressed by CEBPA. Strongly overexpressed in leukemic cells.

Gene Ontology (GO) - Molecular Function for DNAJC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity TAS --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IDA 21179169
GO:0005515 protein binding IEA --
GO:0030544 Hsp70 protein binding IPI 16002468
genes like me logo Genes that share ontologies with DNAJC2: view

Phenotypes for DNAJC2 Gene

GenomeRNAi human phenotypes for DNAJC2:
genes like me logo Genes that share phenotypes with DNAJC2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJC2 Gene

Localization for DNAJC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC2 Gene

Nucleus. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJC2 Gene COMPARTMENTS Subcellular localization image for DNAJC2 gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for DNAJC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 8885239
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 8885239
GO:0005829 cytosol TAS --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with DNAJC2: view

Pathways & Interactions for DNAJC2 Gene

genes like me logo Genes that share pathways with DNAJC2: view

Pathways by source for DNAJC2 Gene

1 Cell Signaling Technology pathway for DNAJC2 Gene

Gene Ontology (GO) - Biological Process for DNAJC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0016568 chromatin modification IEA --
GO:0016569 covalent chromatin modification IEA --
GO:0030308 negative regulation of cell growth IEA --
genes like me logo Genes that share ontologies with DNAJC2: view

No data available for SIGNOR curated interactions for DNAJC2 Gene

Drugs & Compounds for DNAJC2 Gene

No Compound Related Data Available

Transcripts for DNAJC2 Gene

Unigene Clusters for DNAJC2 Gene

DnaJ (Hsp40) homolog, subfamily C, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2:
SP3: - -
SP4: - -
SP5: -
SP6:

Relevant External Links for DNAJC2 Gene

GeneLoc Exon Structure for
DNAJC2
ECgene alternative splicing isoforms for
DNAJC2

Expression for DNAJC2 Gene

mRNA expression in normal human tissues for DNAJC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJC2 Gene

This gene is overexpressed in Breast (11.6), Testis (9.3), Lymph node (7.1), and Peripheral blood mononuclear cells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNAJC2 Gene



Protein tissue co-expression partners for DNAJC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJC2 Gene:

DNAJC2

SOURCE GeneReport for Unigene cluster for DNAJC2 Gene:

Hs.558476

mRNA Expression by UniProt/SwissProt for DNAJC2 Gene:

Q99543-DNJC2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with DNAJC2: view

Primer Products

No data available for mRNA differential expression in normal tissues for DNAJC2 Gene

Orthologs for DNAJC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNAJC2 34
  • 94.63 (n)
  • 97.91 (a)
DNAJC2 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJC2 34
  • 94.86 (n)
  • 98.14 (a)
DNAJC2 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajc2 34
  • 90.12 (n)
  • 94.2 (a)
Dnajc2 16
Dnajc2 35
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DNAJC2 34
  • 99.73 (n)
  • 99.68 (a)
DNAJC2 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajc2 34
  • 88.84 (n)
  • 93.72 (a)
oppossum
(Monodelphis domestica)
Mammalia DNAJC2 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC2 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJC2 34
  • 82.23 (n)
  • 87.88 (a)
DNAJC2 35
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJC2 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc2 34
  • 77.28 (n)
  • 83.2 (a)
LOC394933 34
zebrafish
(Danio rerio)
Actinopterygii dnajc2 34
  • 68.42 (n)
  • 77.01 (a)
Dr.19599 34
dnajc2 35
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007541 34
  • 49.65 (n)
  • 50.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10565 34
  • 52.08 (n)
  • 50.38 (a)
CG10565 35
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dnj-11 34
  • 53.29 (n)
  • 45.36 (a)
dnj-11 35
  • 37 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL339C 34
  • 47.09 (n)
  • 42.53 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F03124g 34
  • 49.19 (n)
  • 41.94 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZUO1 34
  • 50.18 (n)
  • 39.36 (a)
ZUO1 35
  • 34 (a)
OneToMany
ZUO1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G11450 34
  • 51.83 (n)
  • 43.9 (a)
rice
(Oryza sativa)
Liliopsida Os04g0377932 34
  • 47.49 (n)
  • 36.11 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2458 34
bread mold
(Neurospora crassa)
Ascomycetes NCU03009 34
  • 46.41 (n)
  • 44.37 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes zuo1 34
  • 50.97 (n)
  • 44.44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4829 35
  • 50 (a)
OneToOne
Species where no ortholog for DNAJC2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC2 Gene

ENSEMBL:
Gene Tree for DNAJC2 (if available)
TreeFam:
Gene Tree for DNAJC2 (if available)

Paralogs for DNAJC2 Gene

Paralogs for DNAJC2 Gene

(1) SIMAP similar genes for DNAJC2 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for DNAJC2 Gene

genes like me logo Genes that share paralogs with DNAJC2: view

Variants for DNAJC2 Gene

Sequence variations from dbSNP and Humsavar for DNAJC2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10257369 -- 103,330,952(+) ATACA(C/T)GAACA intron-variant
rs10258184 -- 103,340,622(+) aggtc(A/G)aagtg intron-variant
rs10266523 -- 103,333,611(+) aaata(C/T)aggcc intron-variant
rs4729911 -- 103,336,143(+) GCCTG(C/T)GCAAC intron-variant
rs36103366 -- 103,337,368(+) AACGT(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC2 Gene

Variant ID Type Subtype PubMed ID
nsv1140832 CNV deletion 24896259
nsv5884 CNV insertion 18451855
nsv831084 CNV gain 17160897

Variation tolerance for DNAJC2 Gene

Residual Variation Intolerance Score: 22.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC2 Gene

Disorders for DNAJC2 Gene

Relevant External Links for DNAJC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJC2

No disorders were found for DNAJC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC2 Gene

Publications for DNAJC2 Gene

  1. Identification of a novel peptide derived from the M-phase phosphoprotein 11 (MPP11) leukemic antigen recognized by human CD8+ cytotoxic T lymphocytes. (PMID: 20231810) Al Qudaihi G. … Dermime S. (Hematol. Oncol. Stem Cell Ther. 2010) 3 4 22 65
  2. The chaperones MPP11 and Hsp70L1 form the mammalian ribosome- associated complex. (PMID: 16002468) Otto H. … Rospert S. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 22 65
  3. Characterization of several leukemia-associated antigens inducing humoral immune responses in acute and chronic myeloid leukemia. (PMID: 12800198) Greiner J. … Schmitt M. (Int. J. Cancer 2003) 3 4 22 65
  4. Identification of novel M phase phosphoproteins by expression cloning. (PMID: 8885239) Matsumoto-Taniura N. … Westendorf J.M. (Mol. Biol. Cell 1996) 2 3 4 65
  5. Transcriptional activation of polycomb-repressed genes by ZRF1. (PMID: 21179169) Richly H. … Di Croce L. (Nature 2010) 3 4 65

Products for DNAJC2 Gene

Sources for DNAJC2 Gene

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