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DNAJC2 Gene

protein-coding   GIFtS: 50
GCID: GC07M102952

DnaJ (Hsp40) Homolog, Subfamily C, Member 2

(Previous name: zuotin related factor 1)
(Previous symbol: ZRF1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DnaJ (Hsp40) Homolog, Subfamily C, Member 21 2     MPHOSPH112 3
ZRF11 2 3 5     M-Phase Phosphoprotein 112 3
MPP112 3 5     ZUO12
Zuotin Related Factor 11 2     DnaJ Homolog Subfamily C Member 22
Zuotin-Related Factor 12 3     

External Ids:    HGNC: 131921   Entrez Gene: 270002   Ensembl: ENSG000001058217   OMIM: 6055025   UniProtKB: Q995433   

Export aliases for DNAJC2 gene to outside databases

Previous GC identifers: GC07M102741 GC07M097315


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNAJC2 Gene:
This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J
domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable
of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent
polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and
expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are
associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6.
Alternatively spliced variants which encode different protein isoforms have been described. (provided by RefSeq,
Jul 2008)

GeneCards Summary for DNAJC2 Gene:
DNAJC2 (DnaJ (Hsp40) homolog, subfamily C, member 2) is a protein-coding gene. Diseases associated with DNAJC2 include chronic myeloid leukemia, and acute myeloid leukemia. GO annotations related to this gene include ubiquitin binding and chromatin binding. An important paralog of this gene is DNAJC1.

UniProtKB/Swiss-Prot: DNJC2_HUMAN, Q99543
Function: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic,
acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding
or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase
activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide
chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically
recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb
PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence
5'-GTCAAGC-3'

Gene Wiki entry for DNAJC2 (ZRF1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAJC2 gene promoter:
         SRF   Pax-5   SRF (504 AA)   Tal-1beta   E47   Max   Egr-2   PPAR-gamma1   PPAR-gamma2   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for DNAJC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAJC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22-q32

DNAJC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJC2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M102952:  view genomic region     (about GC identifiers)

Start:
102,952,921 bp from pter      End:
102,985,320 bp from pter
Size:
32,400 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 102,313,287-102,345,686     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DNJC2_HUMAN, Q99543 (See protein sequence)
Recommended Name: DnaJ homolog subfamily C member 2  
Size: 621 amino acids; 71996 Da
Subunit: Interacts (via ZRF1-UBD region) with ID1 (By similarity). Component of ribosome-associated complex (RAC),
a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2
Miscellaneous: Constitutes a myeloid leukemia-associated antigen and might be a target for leukemia T-cell therapy
Sequence caution: Sequence=AAI39752.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAA66913.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for DNAJC2:
2M2E (3D)    
Secondary accessions: A4VCI0 Q9BVX1
Alternative splicing: 2 isoforms:  Q99543-1   Q99543-2   

Explore the universe of human proteins at neXtProt for DNAJC2: NX_Q99543

Explore proteomics data for DNAJC2 at MOPED

Post-translational modifications: 

  • Phosphorylated in M (mitotic) phase1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DNAJC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001123359.1  NP_055192.1  

    ENSEMBL proteins: 
     ENSP00000249270   ENSP00000368565   ENSP00000412611   ENSP00000399058   ENSP00000368559  
     ENSP00000406275  

    DNAJC2 Human Recombinant Protein Products:

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    DNAJC2 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    5 InterPro protein domains:
     IPR017884 SANT_dom
     IPR001005 SANT/Myb
     IPR001623 DnaJ_domain
     IPR018253 DnaJ_domain_CS
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q99543

    ProtoNet protein and cluster: Q99543

    UniProtKB/Swiss-Prot: DNJC2_HUMAN, Q99543
    Domain: The ZRF1-UBD region specifically recognizes and binds H2AK119ub. The ZRF1-UBD region is also involved in
    protein-protein interactions with other proteins, suggesting that it may be masked by some regulator, thereby
    preventing its association with H2AK119ub
    Similarity: Contains 1 J domain
    Similarity: Contains 2 SANT domains


    DNAJC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DNJC2_HUMAN, Q99543
    Function: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic,
    acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding
    or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase
    activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide
    chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically
    recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb
    PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence
    5'-GTCAAGC-3'
    Induction: Expression is repressed by CEBPA. Strongly overexpressed in leukemic cells

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IDA--
    GO:0005515protein binding ----
    GO:0030544Hsp70 protein binding IPI16002468
    GO:0042393histone binding IDA--
         
    DNAJC2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Dnajc2 (no phenotypes)

    DNAJC2 for phenotypes           About GeneDecksing

    Animal Models:
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    hsa-mir-30a-5p (MIRT028442), hsa-mir-26b-5p (MIRT028835), hsa-mir-155-5p (MIRT020515), hsa-mir-375 (MIRT019698), hsa-mir-16-5p (MIRT031386)

    Block miRNA regulation of human, mouse, rat DNAJC2 using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DNJC2_HUMAN, Q99543: Nucleus. Cytoplasm, cytosol
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IDA16002468
    GO:0031965nuclear membrane IDA--

    DNAJC2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DNAJC2 About    
    See pathways by source

    SuperPathContained pathways About
    1Translational Control
    Translational Control

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for DNAJC2
        Translational Control



    DNAJC2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DNAJC2
    Interactions:

        Search GeneGlobe Interaction Network for DNAJC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNAJC2 (Q995433 ENSP000003685654) via UniProtKB, MINT, STRING, and/or I2D (see all 138)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST2H2AA3Q6FI133, ENSP000003581584I2D: score=1 STRING: ENSP00000358158
    HIST2H2AA4Q6FI133I2D: score=1 
    HSPA14Q0VDF93, ENSP000003676234I2D: score=1 STRING: ENSP00000367623
    RNF2Q994963, ENSP000003564804I2D: score=1 STRING: ENSP00000356480
    ATP8B2P981983I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0016568chromatin modification IEA--
    GO:0030308negative regulation of cell growth IEA--
    GO:0045893positive regulation of transcription, DNA-templated IDA--

    DNAJC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for DNAJC2 (DNJC2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DNAJC2 gene (2 alternative transcripts): 
    NM_001129887.1  NM_014377.1  

    Unigene Cluster for DNAJC2:

    DnaJ (Hsp40) homolog, subfamily C, member 2
    Hs.558476  [show with all ESTs]
    Unigene Representative Sequence: NM_014377
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000249270 ENST00000475065(uc003vbn.3) ENST00000379263(uc003vbo.3 uc010lix.3 uc003vbp.3 uc003vbq.1)
    ENST00000492497 ENST00000464253 ENST00000475090 ENST00000426036 ENST00000454277
    ENST00000483637 ENST00000379257 ENST00000412522(uc003vbr.1)
    miRNA
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    hsa-miR-3163 hsa-miR-144 hsa-miR-3658 hsa-miR-4328 hsa-miR-340
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    Additional mRNA sequence: 

    BC000859.1 BC012376.1 BC046351.1 BC062703.1 BC125057.1 BC139751.1 X98260.1 

    18 DOTS entries:

    DT.102838904  DT.95069522  DT.91641719  DT.101980113  DT.95367662  DT.100888012  DT.101963658  DT.91662981 
    DT.100888016  DT.95227547  DT.101970896  DT.97855618  DT.121065832  DT.92008760  DT.92454561  DT.428720 
    DT.456141  DT.95367648 

    Selected AceView cDNA sequences (see all 156):

    BM978538 BM554759 BM969862 BM803636 BM450151 BU622358 BX279826 BM798599 
    CR598046 BE672061 BM914755 CB164507 AA543065 AI621015 BF001171 AI140595 
    CB134063 AL832847 BU674241 BE844166 AW612011 BC012376 BC000859 BU071395 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                                                                                                                    
    SP2:                                                                                                                                    
    SP3:                                            -           -                                                                           
    SP4:                          -                 -                                                                                       
    SP5:                                            -                                                                                       


    ECgene alternative splicing isoforms for DNAJC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNAJC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACGATACA
    DNAJC2 Expression
    About this image


    DNAJC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Gonad
             Primary Oocyte Primary Follicle
    DNAJC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAJC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.558476

    UniProtKB/Swiss-Prot: DNJC2_HUMAN, Q99543
    Tissue specificity: Widely expressed

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNAJC2 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnajc21 , 5 DnaJ (Hsp40) homolog, subfamily C, member 21, 5 90.12(n)1
    94.2(a)1
      5 (9.97 cM)5
    227911  NM_009584.41  NP_033610.11 
     217572675 
    chicken
    (Gallus gallus)
    Aves DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 2 82.23(n)
    87.88(a)
      417717  NM_001199325.1  NP_001186254.1 
    lizard
    (Anolis carolinensis)
    Reptilia DNAJC26
    DnaJ (Hsp40) homolog, subfamily C, member 2
    88(a)
    1 ↔ 1
    5(95375984-95399546)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480435592   -- 78.88(n)    48043559 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.195992 Danio rerio cDNA clone IMAGE2640354, partial cds 76.31(n)    BC055125.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG105651 CG10565 52.08(n)
    50.38(a)
      40332  NM_001259927.1  NP_001246856.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dnj-111 dnj-11 53.29(n)
    45.36(a)
      177419  NM_068605.4  NP_501006.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ZUO1(YGR285C)4
    ZUO11
    Ribosome-associated chaperone, functions in ribosome more4
    ZUO11
    50.18(n)1
    39.36(a)1
      7(1063153-1061852)4
    8532021, 4  NP_011801.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G114501 AT3G11450 51.83(n)
    43.9(a)
      820318  NM_111978.2  NP_187752.2 
    rice
    (Oryza sativa)
    Liliopsida Os04g03779321 Os04g0377932 47.49(n)
    36.11(a)
      9268633  NM_001186973.1  NP_001173902.1 


    ENSEMBL Gene Tree for DNAJC2 (if available)
    TreeFam Gene Tree for DNAJC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNAJC2 gene
    DNAJC12  
    1 SIMAP similar gene for DNAJC2 using alignment to 7 protein entries:     DNJC2_HUMAN (see all proteins):
    DNAJB6

    DNAJC2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for DNAJC2
    PGOHUM00000239930 PGOHUM00000243612


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNAJC2 (see all 596)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs665023041,2
    C--102955698(+) TTTTA-/GAGGAGTA 2 -- int10--------
    rs1823857681,2
    --102955801(+) TTGAAC/TCATAA 2 -- int10--------
    rs765679531,2
    F--102955893(+) GTACAG/TTTCTC 2 -- int10--------
    rs1874241201,2
    --102955910(+) AAGCAA/GTTATC 2 -- int10--------
    rs1167991081,2
    F--102956154(+) GTACGT/ACCAAG 2 -- int11Minor allele frequency- A:0.02WA 118
    rs1930582911,2
    C--102956172(+) GATACA/GTGGCT 2 -- int10--------
    rs778197141,2
    C--102956330(+) AATGAA/GAAAAA 2 -- int13Minor allele frequency- G:0.12CSA WA 121
    rs765921681,2
    F--102956381(+) TGCATA/CAGTTA 2 -- int11Minor allele frequency- C:0.02EA 120
    rs2008754271,2
    C--102956432(+) AAACTC/TACCAA 2 -- int10--------
    rs617441561,2
    C,F--102956463(+) TTGCCA/GATAAC 4 I syn11Minor allele frequency- G:0.04NS 46

    HapMap Linkage Disequilibrium report for DNAJC2 (102952921 - 102985320 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DNAJC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5884CNV Insertion18451855
    nsv831084CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAJC2
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAJC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605502    OMIM disorders: --

    5 diseases for DNAJC2:    
    About MalaCards
    chronic myeloid leukemia    acute myeloid leukemia    leukemia    myeloid leukemia
    malaria


    DNAJC2 for disorders           About GeneDecksing


    Export disorders for DNAJC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNAJC2 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with DNAJC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of novel M phase phosphoproteins by expression cloning. (PubMed id 8885239)1, 2, 3 Matsumoto-Taniura N....Westendorf J.M. (Mol. Biol. Cell 1996)
    2. Identification of a novel peptide derived from the M-phase phosphoprotein 11 (MPP11) leukemic antigen recognized by human CD8+ cytotoxic T lymphocytes. (PubMed id 20231810)1, 2, 9 Al Qudaihi G.... Dermime S. (Hematol. Oncol. Stem Cell Ther. 2010)
    3. The chaperones MPP11 and Hsp70L1 form the mammalian ribosome- associated complex. (PubMed id 16002468)1, 2, 9 Otto H.... Rospert S. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    4. Characterization of several leukemia-associated antigens inducing humoral immune responses in acute and chronic myeloid leukemia. (PubMed id 12800198)1, 2, 9 Greiner J.... Schmitt M. (Int. J. Cancer 2003)
    5. Transcriptional activation of polycomb-repressed genes by ZRF1. (PubMed id 21179169)1, 2 Richly H.... Di Croce L. (Nature 2010)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Human Mpp11 J protein: ribosome-tethered molecular chaperones are ubiquitous. (PubMed id 15802566)1, 2 Hundley H.A.... Craig E.A. (Science 2005)
    8. mRNA expression of leukemia-associated antigens in patients with acute myeloid leukemia for the development of specific immunotherapies. (PubMed id 14696097)1, 2 Greiner J.... Schmitt M. (Int. J. Cancer 2004)
    9. A putative oncogenic role for MPP11 in head and neck squamous cell cancer. (PubMed id 11034098)1, 2 Resto V.A.... Sidransky D. (Cancer Res. 2000)
    10. Zrf1 is required to establish and maintain neural progenitor identity. (PubMed id 24449271)1 Aloia L....Di Croce L. (amp 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27000 HGNC: 13192 AceView: ZRF1 Ensembl:ENSG00000105821 euGenes: HUgn27000
    ECgene: DNAJC2 H-InvDB: DNAJC2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DNAJC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNAJC2 gene:
    Search GeneIP for patents involving DNAJC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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