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DNAJC19 Gene

protein-coding   GIFtS: 58
GCID: GC03M180701

DnaJ (Hsp40) Homolog, Subfamily C, Member 19

  See DNAJC19-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
DnaJ (Hsp40) Homolog, Subfamily C, Member 191 2     Homolog Of Yeast TIM142
TIM142 3 5     Mitochondrial Import Inner Membrane Translocase Subunit TIM142
TIMM142 3     DnaJ Homolog Subfamily C Member 193
PAM182     

External Ids:    HGNC: 305281   Entrez Gene: 1311182   Ensembl: ENSG000002059817   OMIM: 6089775   UniProtKB: Q96DA63   
ORGUL members:         

Export aliases for DNAJC19 gene to outside databases

Previous GC identifers: GC03M182185 GC03M178105


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNAJC19 Gene:
The protein encoded by this gene is thought to be part of a complex involved in the ATP-dependent transport of
transit peptide-containing proteins from the inner cell membrane to the mitochondrial matrix. Defects in this
gene are a cause of 3-methylglutaconic aciduria type 5 (MGA5), also known as dilated cardiomyopathy with ataxia
(DCMA). Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been
identified on chromosomes 1, 2, 6, 10, 14 and 19. (provided by RefSeq, Jan 2012)

GeneCards Summary for DNAJC19 Gene:
DNAJC19 (DnaJ (Hsp40) homolog, subfamily C, member 19) is a protein-coding gene. Diseases associated with DNAJC19 include dilated cardiomyopathy with ataxia syndrome, and 3 methylglutaconic aciduria type v. An important paralog of this gene is DNAJC15.

UniProtKB/Swiss-Prot: TIM14_HUMAN, Q96DA6
Function: Probable component of the PAM complex, a complex required for the translocation of transit
peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May
act as a co-chaperone that stimulate the ATP-dependent activity (By similarity)

Gene Wiki entry for DNAJC19 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAJC19 gene promoter:
         TBP   SRF   Pbx1a   SRF (504 AA)   POU3F2   LCR-F1   HNF-1A   POU2F1   POU2F1a   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJC19 promoter sequence
   Search Chromatin IP Primers for DNAJC19

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAJC19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.33   Ensembl cytogenetic band:  3q26.33   HGNC cytogenetic band: 3q26.33

DNAJC19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJC19 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M180701:  view genomic region     (about GC identifiers)

Start:
180,701,497 bp from pter      End:
180,707,562 bp from pter
Size:
6,066 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for DNAJC19

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TIM14_HUMAN, Q96DA6 (See protein sequence)
Recommended Name: Mitochondrial import inner membrane translocase subunit TIM14  
Size: 116 amino acids; 12499 Da
Subunit: Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or
GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 (By similarity)
Secondary accessions: B2R4B1 C9JBV1
Alternative splicing: 2 isoforms:  Q96DA6-1   Q96DA6-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for DNAJC19: NX_Q96DA6

Explore proteomics data for DNAJC19 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys34, Lys42
  • Modification sites at PhosphoSitePlus

  • See DNAJC19 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001177162.1  NP_660304.1  

    ENSEMBL proteins: 
     ENSP00000372005   ENSP00000418058   ENSP00000419991   ENSP00000420767   ENSP00000419191  
    Reactome Protein details: Q96DA6

    DNAJC19 Human Recombinant Protein Products:

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    Novus Biologicals DNAJC19 Proteins
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    Cloud-Clone Corp. Proteins for DNAJC19

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    1 InterPro protein domain:
     IPR001623 DnaJ_domain

    Graphical View of Domain Structure for InterPro Entry Q96DA6

    ProtoNet protein and cluster: Q96DA6

    1 Blocks protein domain: IPB005341 Protein of unknown function UPF0108

    UniProtKB/Swiss-Prot: TIM14_HUMAN, Q96DA6
    Similarity: Belongs to the TIM14 family
    Similarity: Contains 1 J domain


    Find genes that share domains with DNAJC19           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIM14_HUMAN, Q96DA6
    Function: Probable component of the PAM complex, a complex required for the translocation of transit
    peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May
    act as a co-chaperone that stimulate the ATP-dependent activity (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for DNAJC19:

     Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNAJC19
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DNAJC19
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    miRTarBase miRNAs that target DNAJC19:
    hsa-mir-192-5p (MIRT026867), hsa-mir-155-5p (MIRT001552), hsa-mir-215-5p (MIRT024336), hsa-mir-149-5p (MIRT045573)

    Block miRNA regulation of human, mouse, rat DNAJC19 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate DNAJC19:
    hsa-miR-3163 hsa-miR-29a* hsa-miR-1827 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidDNAJC19 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC19


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TIM14_HUMAN, Q96DA6: Mitochondrion inner membrane; Single-pass membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    extracellular2
    cytosol1
    endoplasmic reticulum1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA12592411
    GO:0005743mitochondrial inner membrane IEA--
    GO:0016021integral component of membrane NAS16055927

    Find genes that share ontologies with DNAJC19           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DNAJC19 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    2Mitochondrial Protein Import
    Mitochondrial Protein Import


    Find genes that share SuperPaths with DNAJC19           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for DNAJC19
        Mitochondrial protein import


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DNAJC19
    Interactions:

        Search GeneGlobe Interaction Network for DNAJC19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNAJC19 (Q96DA63 ENSP000003720054) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA9P386463, ENSP000002971854I2D: score=1 STRING: ENSP00000297185
    PAM16Q9Y3D73, ENSP000003156934I2D: score=1 STRING: ENSP00000315693
    TIMM17AQ995953, ENSP000003562564I2D: score=1 STRING: ENSP00000356256
    GRPEL1ENSP000002649544STRING: ENSP00000264954
    GRPEL2ENSP000003295584STRING: ENSP00000329558
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding NAS16055927
    GO:0006626protein targeting to mitochondrion TAS--
    GO:0007601visual perception IMP16055927
    GO:0044267cellular protein metabolic process TAS--
    GO:0048806genitalia development IMP16055927

    Find genes that share ontologies with DNAJC19           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNAJC19 (TIM14)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DNAJC19 gene (5 alternative transcripts): 
    NM_001190233.1  NM_145261.3  NM_201259.1  NM_201260.1  NM_201261.1  

    Unigene Cluster for DNAJC19:

    DnaJ (Hsp40) homolog, subfamily C, member 19
    Hs.230601  [show with all ESTs]
    Unigene Representative Sequence: NM_001190233
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382564(uc021xhv.1 uc003fkt.3 uc021xhw.1 uc021xhx.1 uc003fku.3)
    ENST00000469657 ENST00000486355 ENST00000491873 ENST00000479269 ENST00000478723
    ENST00000485675 ENST00000482363 ENST00000472504
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate DNAJC19:
    hsa-miR-3163 hsa-miR-29a* hsa-miR-1827 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidDNAJC19 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC19
    Primer
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    OriGene qPCR primer pairs and template standards for DNAJC19
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJC19
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat DNAJC19
      QuantiTect SYBR Green Assays in human, mouse, rat DNAJC19
      QuantiFast Probe-based Assays in human, mouse, rat DNAJC19

    Additional mRNA sequence: 

    AK311765.1 BC009702.1 BC073989.1 NR_033721.1 NR_033722.1 NR_033723.1 NR_046073.1 

    22 DOTS entries:

    DT.452253  DT.97773746  DT.120898929  DT.120753424  DT.95195470  DT.100814364  DT.120898972  DT.120898920 
    DT.40132011  DT.101976929  DT.120898955  DT.100675486  DT.120753422  DT.40191023  DT.100646571  DT.101986382 
    DT.120753425  DT.120898784  DT.120898979  DT.95374406  DT.95374409  DT.100814361 

    Selected AceView cDNA sequences (see all 234):

    AI580078 AI476516 BM561224 AI357155 AA865280 AI217563 AI379496 AA234050 
    BM312061 AI335871 AI081719 AA939156 CB159371 AI436771 BX641514 BM052940 
    AA233168 AI001986 NM_201261 AI217356 AA744933 AA884842 NM_201260 AI803291 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNAJC19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DNAJC19 Expression
    About this image

    DNAJC19 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAJC19 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.230601

    UniProtKB/Swiss-Prot: TIM14_HUMAN, Q96DA6
    Tissue specificity: Ubiquitously expressed

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    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNAJC19 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm151185
    Dnajc191
    predicted gene 151185
    DnaJ (Hsp40) homolog, subfamily C, member 191
    92.53(n)1
    98.28(a)1
      7 (54.85 cM)5
    677131  NM_026332.41  NP_080608.31 
     1038826545 
    chicken
    (Gallus gallus)
    Aves DNAJC191 DnaJ (Hsp40) homolog, subfamily C, member 19 80.87(n)
    86.96(a)
      424966  XM_422774.3  XP_422774.1 
    lizard
    (Anolis carolinensis)
    Reptilia DNAJC196
    DnaJ (Hsp40) homolog, subfamily C, member 19
    89(a)
    1 ↔ 1
    3(1472164-1476437)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.70722 Transcribed sequence with weak similarity to protein more 76.44(n)    AL852363.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc732512 hypothetical protein MGC73251 76(n)   393734  BC059589.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73941 CG7394 58.56(n)
    60.36(a)
      39294  NM_001274785.1  NP_001261714.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dnj-211 dnj-21 60.38(n)
    54.72(a)
      172231  NM_059261.4  NP_491662.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MDJ2(YNL328C)4 Constituent of the mitochondrial import motor associated more   --   14(23274-22834) 855388  NP_014071.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G357951 AT2G35795 55.35(n)
    50.94(a)
      818152  NM_129138.3  NP_565824.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g01923001 Os07g0192300 55.76(n)
    49.53(a)
      4342627  NM_001065634.1  NP_001059099.1 


    ENSEMBL Gene Tree for DNAJC19 (if available)
    TreeFam Gene Tree for DNAJC19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNAJC19 gene
    DNAJC152  
    1 SIMAP similar gene for DNAJC19 using alignment to 3 protein entries:     TIM14_HUMAN (see all proteins):
    DNAJC15

    Find genes that share paralogs with DNAJC19           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for DNAJC19 (see all 9)
    PGOHUM00000238823 PGOHUM00000248154 PGOHUM00000234323 PGOHUM00000234324 PGOHUM00000244030


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNAJC19 (see all 157)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1387559651,2
    C--178108070(+) TTTTG-/T/TT  
            
    GTTTT
    6 -- int10--------
    rs1133486831,2
    C--178108075(+) TTTTTG/-TTTTT 6 -- int11Minor allele frequency- -:0.50CSA 2
    rs18056341,2
    C,H--180564309(+) CATACA/GCTAAA 6 -- ds50015Minor allele frequency- G:0.00EA NS NA 300
    rs1455473051,2
    C--180564327(+) AGACTC/TCATCA 6 -- ds50010--------
    rs1819102121,2
    --180564539(+) CTCCTA/GTTGAG 6 -- ds50010--------
    rs784376371,2
    C,F--180564552(+) ATACAT/CACTAG 6 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1488561521,2
    C--180564578(+) TTATAC/TAGGTC 6 -- ds50010--------
    rs1469640031,2
    C--180564915(+) GAGGTG/TGAGGC 6 -- ut31 nc-transcript-variant0--------
    rs1480748911,2
    C--180565017(+) AGAAT-/ACACACA 6 -- ut31 nc-transcript-variant0--------
    rs1862476621,2
    --180565070(+) TTAAAC/TTCACT 6 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for DNAJC19 (180701497 - 180707562 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DNAJC19: --
    Human Gene Mutation Database (HGMD): DNAJC19
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAJC19
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAJC19

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608977   
    OMIM disorders: 610198  
    UniProtKB/Swiss-Prot: TIM14_HUMAN, Q96DA6
  • 3-methylglutaconic aciduria 5 (MGA5) [MIM:610198]: An autosomal recessive disorder characterized by
    early-onset dilated cardiomyopathy, growth failure, cerebellar ataxia causing significant motor delays,
    testicular dysgenesis, growth failure and significant increases in urine organic acids, particularly
    3-methylglutaconic acid and 3-methylglutaric acid. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 4 diseases for DNAJC19:    
    About MalaCards
    dilated cardiomyopathy with ataxia syndrome    3 methylglutaconic aciduria type v    barth syndrome    dilated cardiomyopathy

    1 disease from the University of Copenhagen DISEASES database for DNAJC19:
    Barth syndrome

    Find genes that share disorders with DNAJC19           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: DNAJC19 (1 document)

    Export disorders for DNAJC19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNAJC19 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with DNAJC19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutation of DNAJC19, a human homologue of yeast inner mitochondrial membrane co-chaperones, causes DCMA syndrome, a novel autosomal recessive Barth syndrome-like condition. (PubMed id 16055927)1, 2, 9 Davey K.M.... Bernier F.P. (J. Med. Genet. 2006)
    2. The mitochondrial protein translocation motor: structural conservation between the human and yeast Tim14/Pam18-Tim16/Pam16 co-chaperones. (PubMed id 19564938)1, 3 Elsner S....Azem A. (Int J Mol Sci 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Characterization of the human heart mitochondrial proteome. (PubMed id 12592411)1, 2 Taylor S.W.... Ghosh S.S. (Nat. Biotechnol. 2003)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. New mutation of mitochondrial DNAJC19 causing dilated and noncompaction cardiomyopathy, anemia, ataxia, and male genital anomalies. (PubMed id 22797137)1 Ojala T....Tyni T. (Pediatr. Res. 2012)
    7. Enhanced J-protein interaction and compromised protein stability of mtHsp70 variants lead to mitochondrial dysfunction in Parkinson's disease. (PubMed id 22544056)1 Goswami A.V....D'Silva P. (Hum. Mol. Genet. 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 131118 HGNC: 30528 AceView: TIM14 Ensembl:ENSG00000205981 euGenes: HUgn131118
    ECgene: DNAJC19 H-InvDB: DNAJC19

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DNAJC19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNAJC19 gene:
    Search GeneIP for patents involving DNAJC19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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