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Aliases for DNAJC18 Gene

Aliases for DNAJC18 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C18 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 18 2

External Ids for DNAJC18 Gene

Previous GeneCards Identifiers for DNAJC18 Gene

  • GC05M138776
  • GC05M133935

Summaries for DNAJC18 Gene

GeneCards Summary for DNAJC18 Gene

DNAJC18 (DnaJ Heat Shock Protein Family (Hsp40) Member C18) is a Protein Coding gene. An important paralog of this gene is DNAJB14.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC18 Gene

Genomics for DNAJC18 Gene

Regulatory Elements for DNAJC18 Gene

Enhancers for DNAJC18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F139438 1 ENCODE 57.9 +5.1 5100 1.8 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF207 ZNF143 DNAJC18 RPL7P19 ECSCR EGR1 GC05P139409 GC05P139410
GH05F139413 0.8 Ensembl ENCODE 52.2 +27.4 27442 6.6 ARNT CREB3L1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 ZNF766 ZNF143 DNAJC18 RNU5B-4P ECSCR PROB1 MZB1 SLC23A1 ETF1 PAIP2 SIL1 MATR3
GH05F139426 0.4 ENCODE 47.5 +17.9 17862 1.2 ELF3 ARID4B DMAP1 RAD21 THRB ZSCAN9 ZNF48 RARA ZNF335 CREM DNAJC18 RNU5B-4P ECSCR GC05P139409 GC05P139410
GH05F139407 0.4 Ensembl 38.7 +36.9 36891 0.8 CTCF TFAP4 SAP130 MLX ZIC2 ZNF644 RAD21 ZNF335 ZNF600 SRF DNAJC18 SLC23A1 GC05P139409 GC05P139410 SPATA24
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DNAJC18 on UCSC Golden Path with GeneCards custom track

Genomic Location for DNAJC18 Gene

139,408,588 bp from pter
139,444,491 bp from pter
35,904 bases
Minus strand

Genomic View for DNAJC18 Gene

Genes around DNAJC18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC18 Gene

Proteins for DNAJC18 Gene

  • Protein details for DNAJC18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily C member 18
    Protein Accession:

    Protein attributes for DNAJC18 Gene

    358 amino acids
    Molecular mass:
    41551 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DNAJC18 Gene

Post-translational modifications for DNAJC18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DNAJC18 Gene

Domains & Families for DNAJC18 Gene

Gene Families for DNAJC18 Gene

Protein Domains for DNAJC18 Gene

Suggested Antigen Peptide Sequences for DNAJC18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 J domain.
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJC18: view

Function for DNAJC18 Gene

Phenotypes for DNAJC18 Gene

GenomeRNAi human phenotypes for DNAJC18:
genes like me logo Genes that share phenotypes with DNAJC18: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJC18 Gene

Localization for DNAJC18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC18 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for DNAJC18 Gene COMPARTMENTS Subcellular localization image for DNAJC18 gene
Compartment Confidence
cytosol 4
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DNAJC18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DNAJC18: view

Pathways & Interactions for DNAJC18 Gene

SuperPathways for DNAJC18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJC18 Gene


No data available for Pathways by source and SIGNOR curated interactions for DNAJC18 Gene

Transcripts for DNAJC18 Gene

Unigene Clusters for DNAJC18 Gene

DnaJ (Hsp40) homolog, subfamily C, member 18:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC18 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP3: -
SP4: - -

Relevant External Links for DNAJC18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJC18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DNAJC18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJC18 Gene

This gene is overexpressed in Tlymphocyte (39.2), Monocytes (18.5), and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DNAJC18 Gene

Protein tissue co-expression partners for DNAJC18 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJC18 Gene:


SOURCE GeneReport for Unigene cluster for DNAJC18 Gene:

genes like me logo Genes that share expression patterns with DNAJC18: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DNAJC18 Gene

Orthologs for DNAJC18 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNAJC18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DNAJC18 34 35
  • 99.35 (n)
(Bos Taurus)
Mammalia DNAJC18 34 35
  • 93.48 (n)
(Canis familiaris)
Mammalia DNAJC18 34 35
  • 92.13 (n)
(Mus musculus)
Mammalia Dnajc18 34 16 35
  • 85.62 (n)
(Rattus norvegicus)
Mammalia Dnajc18 34
  • 84.28 (n)
(Monodelphis domestica)
Mammalia DNAJC18 35
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia DNAJC18 35
  • 68 (a)
(Gallus gallus)
Aves DNAJC18 34 35
  • 71.77 (n)
(Anolis carolinensis)
Reptilia DNAJC18 35
  • 68 (a)
(Danio rerio)
Actinopterygii dnajc18 34 35
  • 61.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3061 35
  • 32 (a)
CG30156 35
  • 22 (a)
(Caenorhabditis elegans)
Secernentea dnj-1 35
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HLJ1 35
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
Species where no ortholog for DNAJC18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DNAJC18 Gene

Gene Tree for DNAJC18 (if available)
Gene Tree for DNAJC18 (if available)

Paralogs for DNAJC18 Gene

Paralogs for DNAJC18 Gene

genes like me logo Genes that share paralogs with DNAJC18: view

Variants for DNAJC18 Gene

Sequence variations from dbSNP and Humsavar for DNAJC18 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10463976 -- 139,430,153(+) gactt(C/G)tatca intron-variant
rs10900863 -- 139,436,491(+) taTTT(A/G)GATTG intron-variant
rs10900864 -- 139,437,401(-) ACGTA(C/T)AGTGA reference, synonymous-codon
rs111239564 -- 139,425,006(+) GTACC(C/T)GAGGT reference, missense
rs111385187 -- 139,432,395(+) CCTGA(C/T)CTTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC18 Gene

Variant ID Type Subtype PubMed ID
esv2762551 CNV gain 21179565
esv3570440 CNV loss 25503493
nsv472002 CNV novel sequence insertion 20440878
nsv474124 CNV novel sequence insertion 20440878
nsv519808 CNV loss 19592680

Variation tolerance for DNAJC18 Gene

Residual Variation Intolerance Score: 68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 21.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC18 Gene

Disorders for DNAJC18 Gene

Relevant External Links for DNAJC18

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DNAJC18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC18 Gene

Publications for DNAJC18 Gene

  1. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
  2. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M. … Lan Q. (Environ. Mol. Mutagen. 2009) 3 46 64
  3. Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. (PMID: 19240791) Graubert T.A. … Walter M.J. (PLoS ONE 2009) 3 46 64
  4. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PMID: 19625176) Hosgood H.D. … Lan Q. (Respir Med 2009) 3 46 64
  5. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PMID: 18676680) Hosgood H.D. … Lan Q. (Carcinogenesis 2008) 3 46 64

Products for DNAJC18 Gene

Sources for DNAJC18 Gene

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