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Aliases for DNAJC18 Gene

Aliases for DNAJC18 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C18 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 18 2

External Ids for DNAJC18 Gene

Previous GeneCards Identifiers for DNAJC18 Gene

  • GC05M138776
  • GC05M133935

Summaries for DNAJC18 Gene

GeneCards Summary for DNAJC18 Gene

DNAJC18 (DnaJ Heat Shock Protein Family (Hsp40) Member C18) is a Protein Coding gene. An important paralog of this gene is DNAJB14.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC18 Gene

Genomics for DNAJC18 Gene

Regulatory Elements for DNAJC18 Gene

Enhancers for DNAJC18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G139413 1.4 Ensembl ENCODE 62.5 +27.4 27442 6.6 FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 FEZF1 ZNF2 ZBTB7B YY1 DNAJC18 IGIP RNU5B-4P ECSCR PROB1 MZB1 SLC23A1 PAIP2 LRRTM2 SIL1
GH05G139381 1.9 FANTOM5 Ensembl ENCODE dbSUPER 41 +54.8 54774 15.5 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 DNAJC18 PURA SLC23A1 PAIP2 SIL1 MATR3 PROB1 MZB1
GH05G139438 1.1 ENCODE 57.9 +5.1 5100 1.8 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 ZNF766 DNAJC18 PURA GC05P139410 GC05P139409
GH05G139443 1.1 Ensembl ENCODE 42.6 -1.1 -1112 4.6 PKNOX1 ATF1 TBL1XR1 SIN3A KLF17 BMI1 GATA2 ZNF366 SCRT2 FOS DNAJC18 IGIP LRRTM2 PURA LINC01024 GC05P139448
GH05G139426 0.9 ENCODE 47.5 +17.9 17862 1.2 ELF3 FOXA2 ARID4B DMAP1 THRB ZSCAN9 ZNF48 RAD21 RARA ZNF335 DNAJC18 RNU5B-4P ECSCR GC05P139410 GC05P139409
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DNAJC18 on UCSC Golden Path with GeneCards custom track

Genomic Location for DNAJC18 Gene

Chromosome:
5
Start:
139,408,588 bp from pter
End:
139,444,491 bp from pter
Size:
35,904 bases
Orientation:
Minus strand

Genomic View for DNAJC18 Gene

Genes around DNAJC18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC18 Gene

Proteins for DNAJC18 Gene

  • Protein details for DNAJC18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H819-DJC18_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 18
    Protein Accession:
    Q9H819

    Protein attributes for DNAJC18 Gene

    Size:
    358 amino acids
    Molecular mass:
    41551 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DNAJC18 Gene

Post-translational modifications for DNAJC18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DNAJC18 Gene

Domains & Families for DNAJC18 Gene

Gene Families for DNAJC18 Gene

Protein Domains for DNAJC18 Gene

Suggested Antigen Peptide Sequences for DNAJC18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNAJC18: view

No data available for UniProtKB/Swiss-Prot for DNAJC18 Gene

Function for DNAJC18 Gene

Phenotypes for DNAJC18 Gene

GenomeRNAi human phenotypes for DNAJC18:
genes like me logo Genes that share phenotypes with DNAJC18: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJC18 Gene

Localization for DNAJC18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC18 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJC18 gene
Compartment Confidence
cytosol 4
mitochondrion 1
peroxisome 1
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DNAJC18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DNAJC18: view

Pathways & Interactions for DNAJC18 Gene

SuperPathways for DNAJC18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJC18 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DNAJC18 Gene

Drugs & Compounds for DNAJC18 Gene

No Compound Related Data Available

Transcripts for DNAJC18 Gene

Unigene Clusters for DNAJC18 Gene

DnaJ (Hsp40) homolog, subfamily C, member 18:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC18 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1:
SP2:
SP3: -
SP4: - -

Relevant External Links for DNAJC18 Gene

GeneLoc Exon Structure for
DNAJC18
ECgene alternative splicing isoforms for
DNAJC18

Expression for DNAJC18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJC18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJC18 Gene

This gene is overexpressed in Tlymphocyte (39.2), Monocytes (18.5), and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DNAJC18 Gene



Protein tissue co-expression partners for DNAJC18 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJC18 Gene:

DNAJC18

SOURCE GeneReport for Unigene cluster for DNAJC18 Gene:

Hs.483537

Evidence on tissue expression from TISSUES for DNAJC18 Gene

  • Nervous system(4.5)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with DNAJC18: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJC18 Gene

Orthologs for DNAJC18 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNAJC18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC18 34 35
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia DNAJC18 34 35
  • 93.48 (n)
dog
(Canis familiaris)
Mammalia DNAJC18 34 35
  • 92.13 (n)
mouse
(Mus musculus)
Mammalia Dnajc18 34 16 35
  • 85.62 (n)
rat
(Rattus norvegicus)
Mammalia Dnajc18 34
  • 84.28 (n)
oppossum
(Monodelphis domestica)
Mammalia DNAJC18 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC18 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJC18 34 35
  • 71.77 (n)
lizard
(Anolis carolinensis)
Reptilia DNAJC18 35
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dnajc18 34 35
  • 61.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3061 35
  • 32 (a)
ManyToMany
CG30156 35
  • 22 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dnj-1 35
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HLJ1 35
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToMany
Species where no ortholog for DNAJC18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DNAJC18 Gene

ENSEMBL:
Gene Tree for DNAJC18 (if available)
TreeFam:
Gene Tree for DNAJC18 (if available)

Paralogs for DNAJC18 Gene

Paralogs for DNAJC18 Gene

genes like me logo Genes that share paralogs with DNAJC18: view

Variants for DNAJC18 Gene

Sequence variations from dbSNP and Humsavar for DNAJC18 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000092606 -- 139,437,068(+) ATCCT(G/T)GAGAA intron-variant
rs1000154802 -- 139,413,980(+) CTGTG(A/T)AGACA utr-variant-3-prime
rs1000226115 -- 139,430,048(+) ACTTT(C/T)GATCT intron-variant
rs1000235682 -- 139,434,704(+) TCTTA(A/T)ATCCT intron-variant
rs1000443009 -- 139,437,318(+) CAGGC(A/G)CTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC18 Gene

Variant ID Type Subtype PubMed ID
esv2762551 CNV gain 21179565
esv3570440 CNV loss 25503493
nsv472002 CNV novel sequence insertion 20440878
nsv474124 CNV novel sequence insertion 20440878
nsv519808 CNV loss 19592680

Variation tolerance for DNAJC18 Gene

Residual Variation Intolerance Score: 68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 21.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJC18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC18 Gene

Disorders for DNAJC18 Gene

Relevant External Links for DNAJC18

Genetic Association Database (GAD)
DNAJC18
Human Genome Epidemiology (HuGE) Navigator
DNAJC18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJC18

No disorders were found for DNAJC18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC18 Gene

Publications for DNAJC18 Gene

  1. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
  2. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M. … Lan Q. (Environ. Mol. Mutagen. 2009) 3 46 64
  3. Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. (PMID: 19240791) Graubert T.A. … Walter M.J. (PLoS ONE 2009) 3 46 64
  4. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PMID: 19625176) Hosgood H.D. … Lan Q. (Respir Med 2009) 3 46 64
  5. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PMID: 18676680) Hosgood H.D. … Lan Q. (Carcinogenesis 2008) 3 46 64

Products for DNAJC18 Gene

Sources for DNAJC18 Gene

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