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Aliases for DNAJC17 Gene

Aliases for DNAJC17 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C17 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 17 2

External Ids for DNAJC17 Gene

Previous GeneCards Identifiers for DNAJC17 Gene

  • GC15M038848
  • GC15M041060
  • GC15M017908

Summaries for DNAJC17 Gene

GeneCards Summary for DNAJC17 Gene

DNAJC17 (DnaJ Heat Shock Protein Family (Hsp40) Member C17) is a Protein Coding gene. Diseases associated with DNAJC17 include Ileocolitis. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is DNAJC12.

UniProtKB/Swiss-Prot for DNAJC17 Gene

  • May negatively affect PAX8-induced thyroglobulin/TG transcription.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC17 Gene

Genomics for DNAJC17 Gene

Regulatory Elements for DNAJC17 Gene

Enhancers for DNAJC17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F040090 1.6 VISTA FANTOM5 ENCODE 56.5 +707.1 707120 18.8 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ENSG00000259211 DNAJC17 BMF CHST14 RPLP0P10 BAHD1 SRP14 EIF2AK4 SRP14-AS1 ENSG00000259432
GH15F040955 1 Ensembl ENCODE 47.2 -149.8 -149791 3.4 ZNF493 ZFP64 ZEB1 ZNF121 ZNF354C ZNF202 ZNF680 ZNF362 SP3 ZNF654 ENSG00000259211 RAD51-AS1 DNAJC17 ENSG00000260814 BAHD1 RPAP1 NDUFAF1 CHST14 SRP14 CHAC1
GH15F040959 0.7 Ensembl ENCODE 42.7 -153.1 -153125 1.8 TBP ZFP64 MAX ZNF140 ZNF266 ZNF514 ZIC2 ZNF101 ZNF664 ZFHX2 ENSG00000259211 RAD51-AS1 BAHD1 ENSG00000260814 DNAJC17 RPAP1 OIP5-AS1 SRP14 NDUFAF1 EHD4-AS1
GH15F040693 0.5 ENCODE 27.2 +112.4 112391 3.1 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 C15orf57 ENSG00000259211 DNAJC17 CHST14 RAD51 BAHD1 KNSTRN RPAP1 EIF2AK4 BMF
GH15F041401 0.2 ENCODE 25.7 -595.0 -595022 1.6 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CBX5 ZNF143 NDUFAF1 DNAJC17 GANC CHST14 LOC105370795 RAD51-AS1 ENSG00000259211 BAHD1 RPAP1 EHD4-AS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DNAJC17 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJC17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000020595 -122 2001 HDGF PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 YY1 ZNF207 ZNF143 SP3

Genomic Location for DNAJC17 Gene

Chromosome:
15
Start:
40,765,155 bp from pter
End:
40,807,478 bp from pter
Size:
42,324 bases
Orientation:
Minus strand

Genomic View for DNAJC17 Gene

Genes around DNAJC17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC17 Gene

Proteins for DNAJC17 Gene

  • Protein details for DNAJC17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVM6-DJC17_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 17
    Protein Accession:
    Q9NVM6

    Protein attributes for DNAJC17 Gene

    Size:
    304 amino acids
    Molecular mass:
    34687 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DNAJC17 Gene

neXtProt entry for DNAJC17 Gene

Post-translational modifications for DNAJC17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DNAJC17 Gene

Domains & Families for DNAJC17 Gene

Suggested Antigen Peptide Sequences for DNAJC17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NVM6

UniProtKB/Swiss-Prot:

DJC17_HUMAN :
  • Contains 1 J domain.
Domain:
  • Contains 1 J domain.
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with DNAJC17: view

Function for DNAJC17 Gene

Molecular function for DNAJC17 Gene

UniProtKB/Swiss-Prot Function:
May negatively affect PAX8-induced thyroglobulin/TG transcription.

Gene Ontology (GO) - Molecular Function for DNAJC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with DNAJC17: view

Phenotypes for DNAJC17 Gene

genes like me logo Genes that share phenotypes with DNAJC17: view

Animal Models for DNAJC17 Gene

MGI Knock Outs for DNAJC17:

Animal Model Products

  • Taconic Biosciences Mouse Models for DNAJC17

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DNAJC17 Gene

Localization for DNAJC17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC17 Gene

Cytoplasm. Nucleus. Note=Predominantly nuclear. {ECO:0000250 UniProtKB:D3ZSC8}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJC17 Gene COMPARTMENTS Subcellular localization image for DNAJC17 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for DNAJC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DNAJC17: view

Pathways & Interactions for DNAJC17 Gene

SuperPathways for DNAJC17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:1901998 toxin transport IEA --
genes like me logo Genes that share ontologies with DNAJC17: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJC17 Gene

Transcripts for DNAJC17 Gene

Unigene Clusters for DNAJC17 Gene

DnaJ (Hsp40) homolog, subfamily C, member 17:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC17 Gene

No ASD Table

Relevant External Links for DNAJC17 Gene

GeneLoc Exon Structure for
DNAJC17
ECgene alternative splicing isoforms for
DNAJC17

Expression for DNAJC17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DNAJC17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJC17 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.4) and Lung (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNAJC17 Gene



Protein tissue co-expression partners for DNAJC17 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJC17 Gene:

DNAJC17

SOURCE GeneReport for Unigene cluster for DNAJC17 Gene:

Hs.511069
genes like me logo Genes that share expression patterns with DNAJC17: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DNAJC17 Gene

Orthologs for DNAJC17 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJC17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC17 34 35
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia DNAJC17 34 35
  • 90.79 (n)
cow
(Bos Taurus)
Mammalia DNAJC17 34 35
  • 89.14 (n)
mouse
(Mus musculus)
Mammalia Dnajc17 34 16 35
  • 88.12 (n)
rat
(Rattus norvegicus)
Mammalia Dnajc17 34
  • 87.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC17 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJC17 34 35
  • 71.95 (n)
lizard
(Anolis carolinensis)
Reptilia DNAJC17 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc17 34
  • 66.89 (n)
Str.10407 34
African clawed frog
(Xenopus laevis)
Amphibia MGC69064 34
zebrafish
(Danio rerio)
Actinopterygii dnajc17 34 35
  • 65.2 (n)
zgc56091 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10984 34
fruit fly
(Drosophila melanogaster)
Insecta CG17187 34 35
  • 54.79 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003825 34
  • 53.4 (n)
worm
(Caenorhabditis elegans)
Secernentea dnj-22 35
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G23590 34
  • 43.42 (n)
rice
(Oryza sativa)
Liliopsida Os03g0136800 34
  • 40.27 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cwf23 34
  • 45.2 (n)
Species where no ortholog for DNAJC17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC17 Gene

ENSEMBL:
Gene Tree for DNAJC17 (if available)
TreeFam:
Gene Tree for DNAJC17 (if available)

Paralogs for DNAJC17 Gene

Paralogs for DNAJC17 Gene

Pseudogenes.org Pseudogenes for DNAJC17 Gene

genes like me logo Genes that share paralogs with DNAJC17: view

Variants for DNAJC17 Gene

Sequence variations from dbSNP and Humsavar for DNAJC17 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs11070294 -- 40,804,146(+) ATATA(G/T)AGAGA intron-variant
rs11070295 -- 40,806,141(+) GCTTC(C/T)TCTTC intron-variant, upstream-variant-2KB
rs11070296 -- 40,806,156(+) AAGCT(C/T)ACTCA intron-variant, upstream-variant-2KB
rs11070297 -- 40,807,151(+) GCCAC(C/T)CGGCG intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs111330839 -- 40,793,115(+) GTCTC(A/G)ATCTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DNAJC17 Gene

Variant ID Type Subtype PubMed ID
esv3636232 CNV loss 21293372
nsv1054764 CNV gain 25217958
nsv827306 CNV loss 20364138

Variation tolerance for DNAJC17 Gene

Residual Variation Intolerance Score: 65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.92; 59.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC17 Gene

Human Gene Mutation Database (HGMD)
DNAJC17
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJC17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC17 Gene

Disorders for DNAJC17 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DNAJC17 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ileocolitis
  • iieocolitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DNAJC17

Genetic Association Database (GAD)
DNAJC17
Human Genome Epidemiology (HuGE) Navigator
DNAJC17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJC17
genes like me logo Genes that share disorders with DNAJC17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNAJC17 Gene

Publications for DNAJC17 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64

Products for DNAJC17 Gene

Sources for DNAJC17 Gene

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