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Aliases for DNAJC17 Gene

Aliases for DNAJC17 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C17 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 17 2

External Ids for DNAJC17 Gene

Previous GeneCards Identifiers for DNAJC17 Gene

  • GC15M038848
  • GC15M041060
  • GC15M017908

Summaries for DNAJC17 Gene

GeneCards Summary for DNAJC17 Gene

DNAJC17 (DnaJ Heat Shock Protein Family (Hsp40) Member C17) is a Protein Coding gene. Diseases associated with DNAJC17 include Ileocolitis. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is DNAJC12.

UniProtKB/Swiss-Prot for DNAJC17 Gene

  • May negatively affect PAX8-induced thyroglobulin/TG transcription.

Additional gene information for DNAJC17 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC17 Gene

Genomics for DNAJC17 Gene

Regulatory Elements for DNAJC17 Gene

Enhancers for DNAJC17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H040090 2.7 VISTA FANTOM5 Ensembl ENCODE dbSUPER 60 +707.1 707120 18 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC ENSG00000259211 DNAJC17 BAHD1 RAD51-AS1 BMF CHST14 EIF2AK4 SRP14-AS1 RPLP0P10 ENSG00000259536
GH15H040762 1.4 ENCODE dbSUPER 22.8 +42.8 42830 4 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 ZNF207 MGA ZFYVE19 ENSG00000259211 CCDC32 DNAJC17 INO80 RAD51-AS1 FAM92A1P1 BAHD1 EIF2AK4
GH15H041401 1.2 ENCODE 25.7 -595.0 -595022 1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CBX5 NDUFAF1 INO80 DNAJC17 MGA ENSG00000259211 GANC BAHD1 VPS39 LOC105370795 RPAP1
GH15H040693 1.1 ENCODE 27.2 +112.4 112391 3 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 DEK CCDC32 INO80 ENSG00000259211 DNAJC17 RAD51 MGA BAHD1 KNSTRN CHST14 RPAP1
GH15H040589 1.2 Ensembl ENCODE 24.1 +216.8 216803 2 HDGF PKNOX1 ATF1 FOXA2 YBX1 ZNF2 YY1 ZNF121 GTF3C2 ZNF143 CCDC32 INO80 RAD51 ENSG00000259211 DNAJC17 BAHD1 RPAP1 RAD51-AS1 BMF RMDN3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DNAJC17 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJC17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000075564 -22 1401 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF207 ZNF143 DEK

Genomic Location for DNAJC17 Gene

Chromosome:
15
Start:
40,765,155 bp from pter
End:
40,807,478 bp from pter
Size:
42,324 bases
Orientation:
Minus strand

Genomic View for DNAJC17 Gene

Genes around DNAJC17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC17 Gene

Proteins for DNAJC17 Gene

  • Protein details for DNAJC17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVM6-DJC17_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 17
    Protein Accession:
    Q9NVM6

    Protein attributes for DNAJC17 Gene

    Size:
    304 amino acids
    Molecular mass:
    34687 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DNAJC17 Gene

neXtProt entry for DNAJC17 Gene

Post-translational modifications for DNAJC17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DNAJC17 Gene

Domains & Families for DNAJC17 Gene

Gene Families for DNAJC17 Gene

Protein Domains for DNAJC17 Gene

Suggested Antigen Peptide Sequences for DNAJC17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNAJC17: view

No data available for UniProtKB/Swiss-Prot for DNAJC17 Gene

Function for DNAJC17 Gene

Molecular function for DNAJC17 Gene

UniProtKB/Swiss-Prot Function:
May negatively affect PAX8-induced thyroglobulin/TG transcription.

Phenotypes From GWAS Catalog for DNAJC17 Gene

Gene Ontology (GO) - Molecular Function for DNAJC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with DNAJC17: view

Phenotypes for DNAJC17 Gene

genes like me logo Genes that share phenotypes with DNAJC17: view

Animal Models for DNAJC17 Gene

MGI Knock Outs for DNAJC17:

Animal Model Products

  • Taconic Biosciences Mouse Models for DNAJC17

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DNAJC17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DNAJC17 Gene

Localization for DNAJC17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC17 Gene

Cytoplasm. Nucleus. Note=Predominantly nuclear. {ECO:0000250 UniProtKB:D3ZSC8}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJC17 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DNAJC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DNAJC17: view

Pathways & Interactions for DNAJC17 Gene

SuperPathways for DNAJC17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:1901998 toxin transport IEA --
genes like me logo Genes that share ontologies with DNAJC17: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJC17 Gene

Drugs & Compounds for DNAJC17 Gene

No Compound Related Data Available

Transcripts for DNAJC17 Gene

Unigene Clusters for DNAJC17 Gene

DnaJ (Hsp40) homolog, subfamily C, member 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DNAJC17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC17 Gene

No ASD Table

Relevant External Links for DNAJC17 Gene

GeneLoc Exon Structure for
DNAJC17
ECgene alternative splicing isoforms for
DNAJC17

Expression for DNAJC17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJC17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJC17 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.4) and Lung (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNAJC17 Gene



Protein tissue co-expression partners for DNAJC17 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJC17 Gene:

DNAJC17

SOURCE GeneReport for Unigene cluster for DNAJC17 Gene:

Hs.511069

Evidence on tissue expression from TISSUES for DNAJC17 Gene

  • Nervous system(4.3)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with DNAJC17: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJC17 Gene

Orthologs for DNAJC17 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJC17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC17 33 34
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia DNAJC17 33 34
  • 90.79 (n)
cow
(Bos Taurus)
Mammalia DNAJC17 33 34
  • 89.14 (n)
mouse
(Mus musculus)
Mammalia Dnajc17 33 16 34
  • 88.12 (n)
rat
(Rattus norvegicus)
Mammalia Dnajc17 33
  • 87.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC17 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJC17 33 34
  • 71.95 (n)
lizard
(Anolis carolinensis)
Reptilia DNAJC17 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc17 33
  • 66.89 (n)
Str.10407 33
African clawed frog
(Xenopus laevis)
Amphibia MGC69064 33
zebrafish
(Danio rerio)
Actinopterygii dnajc17 33 34
  • 65.2 (n)
zgc56091 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10984 33
fruit fly
(Drosophila melanogaster)
Insecta CG17187 33 34
  • 54.79 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003825 33
  • 53.4 (n)
worm
(Caenorhabditis elegans)
Secernentea dnj-22 34
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G23590 33
  • 43.42 (n)
rice
(Oryza sativa)
Liliopsida Os03g0136800 33
  • 40.27 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cwf23 33
  • 45.2 (n)
Species where no ortholog for DNAJC17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC17 Gene

ENSEMBL:
Gene Tree for DNAJC17 (if available)
TreeFam:
Gene Tree for DNAJC17 (if available)

Paralogs for DNAJC17 Gene

Paralogs for DNAJC17 Gene

Pseudogenes.org Pseudogenes for DNAJC17 Gene

genes like me logo Genes that share paralogs with DNAJC17: view

Variants for DNAJC17 Gene

Sequence variations from dbSNP and Humsavar for DNAJC17 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000058877 -- 40,793,346(+) CGTTC(A/G)CTGAG intron-variant, upstream-variant-2KB
rs1000070858 -- 40,775,402(+) CCGGG(A/C/T)GGCTG intron-variant
rs1000083715 -- 40,793,738(+) GTGAG(C/T)GCTCA intron-variant, upstream-variant-2KB
rs1000177756 -- 40,795,160(+) TGATC(C/T)CAACA intron-variant
rs1000210800 -- 40,771,255(+) ATGTT(-/G)GGGGG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DNAJC17 Gene

Variant ID Type Subtype PubMed ID
esv3636232 CNV loss 21293372
nsv1054764 CNV gain 25217958
nsv827306 CNV loss 20364138

Variation tolerance for DNAJC17 Gene

Residual Variation Intolerance Score: 65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.92; 59.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC17 Gene

Human Gene Mutation Database (HGMD)
DNAJC17
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJC17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC17 Gene

Disorders for DNAJC17 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DNAJC17 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
ileocolitis
  • iieocolitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DNAJC17

Genetic Association Database (GAD)
DNAJC17
Human Genome Epidemiology (HuGE) Navigator
DNAJC17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJC17
genes like me logo Genes that share disorders with DNAJC17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNAJC17 Gene

Publications for DNAJC17 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60

Products for DNAJC17 Gene

Sources for DNAJC17 Gene

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