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Aliases for DNAJC16 Gene

Aliases for DNAJC16 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C16 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 16 2
  • KIAA0962 4

External Ids for DNAJC16 Gene

Previous GeneCards Identifiers for DNAJC16 Gene

  • GC01P015599
  • GC01P015725
  • GC01P015853
  • GC01P014372

Summaries for DNAJC16 Gene

GeneCards Summary for DNAJC16 Gene

DNAJC16 (DnaJ Heat Shock Protein Family (Hsp40) Member C16) is a Protein Coding gene. An important paralog of this gene is DNAJA3.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC16 Gene

Genomics for DNAJC16 Gene

Regulatory Elements for DNAJC16 Gene

Promoters for DNAJC16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000001903 187 1601 MLX CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21

Genomic Location for DNAJC16 Gene

15,526,813 bp from pter
15,592,379 bp from pter
65,567 bases
Plus strand

Genomic View for DNAJC16 Gene

Genes around DNAJC16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC16 Gene

Proteins for DNAJC16 Gene

  • Protein details for DNAJC16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily C member 16
    Protein Accession:
    Secondary Accessions:
    • Q68D57
    • Q86X32
    • Q8N5P4

    Protein attributes for DNAJC16 Gene

    782 amino acids
    Molecular mass:
    90591 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA76806.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAJC16 Gene


neXtProt entry for DNAJC16 Gene

Post-translational modifications for DNAJC16 Gene

  • Glycosylation at Asn631
  • Modification sites at PhosphoSitePlus

Other Protein References for DNAJC16 Gene

No data available for DME Specific Peptides for DNAJC16 Gene

Domains & Families for DNAJC16 Gene

Gene Families for DNAJC16 Gene

Protein Domains for DNAJC16 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNAJC16: view

No data available for UniProtKB/Swiss-Prot for DNAJC16 Gene

Function for DNAJC16 Gene

genes like me logo Genes that share phenotypes with DNAJC16: view

Animal Models for DNAJC16 Gene

MGI Knock Outs for DNAJC16:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DNAJC16 Gene

Localization for DNAJC16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC16 Gene

Membrane; Single-pass type IV membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJC16 gene
Compartment Confidence
endoplasmic reticulum 3
cytosol 3
plasma membrane 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DNAJC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DNAJC16: view

Pathways & Interactions for DNAJC16 Gene

SuperPathways for DNAJC16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with DNAJC16: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJC16 Gene

Drugs & Compounds for DNAJC16 Gene

No Compound Related Data Available

Transcripts for DNAJC16 Gene

Unigene Clusters for DNAJC16 Gene

DnaJ (Hsp40) homolog, subfamily C, member 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC16 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16a ·
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: - -

ExUns: 16b · 16c ^ 17
SP8: - -

Relevant External Links for DNAJC16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJC16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJC16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJC16 Gene

This gene is overexpressed in Cerebrospinal fluid (51.8) and Peripheral blood mononuclear cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNAJC16 Gene

Protein tissue co-expression partners for DNAJC16 Gene

NURSA nuclear receptor signaling pathways regulating expression of DNAJC16 Gene:


SOURCE GeneReport for Unigene cluster for DNAJC16 Gene:


Evidence on tissue expression from TISSUES for DNAJC16 Gene

  • Nervous system(4.3)
  • Eye(4.1)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with DNAJC16: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJC16 Gene

Orthologs for DNAJC16 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNAJC16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DNAJC16 34 35
  • 99.57 (n)
(Bos Taurus)
Mammalia DNAJC16 34 35
  • 90.2 (n)
(Canis familiaris)
Mammalia DNAJC16 34 35
  • 89.94 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 89 (a)
-- 35
  • 86 (a)
-- 35
  • 84 (a)
-- 35
  • 82 (a)
(Monodelphis domestica)
Mammalia DNAJC16 35
  • 87 (a)
(Rattus norvegicus)
Mammalia Dnajc16 34
  • 85.04 (n)
(Mus musculus)
Mammalia Dnajc16 34 16 35
  • 83.25 (n)
(Gallus gallus)
Aves DNAJC16 34 35
  • 73.19 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488071 34
  • 68.28 (n)
(Danio rerio)
Actinopterygii dnajc16 34
  • 61.42 (n)
DNAJC16 (1 of 2) 35
  • 60 (a)
DNAJC16 (2 of 2) 35
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG40178 34 35
  • 43.88 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001070 34
  • 43.75 (n)
(Caenorhabditis elegans)
Secernentea dnj-8 34 35
  • 42.74 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HLJ1 35
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
Species where no ortholog for DNAJC16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC16 Gene

Gene Tree for DNAJC16 (if available)
Gene Tree for DNAJC16 (if available)

Paralogs for DNAJC16 Gene

Paralogs for DNAJC16 Gene

(3) SIMAP similar genes for DNAJC16 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DNAJC16: view

Variants for DNAJC16 Gene

Sequence variations from dbSNP and Humsavar for DNAJC16 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000001607 -- 15,556,931(+) TTCTA(C/T)ATCCA intron-variant
rs1000035063 -- 15,572,210(+) GGTTT(-/TTTTGTTTTG)TTTTG intron-variant, utr-variant-3-prime
rs1000054323 -- 15,530,911(+) TCAGA(C/T)TCCTG intron-variant
rs1000137812 -- 15,563,540(+) ACAAA(A/C)AACTG intron-variant
rs1000182129 -- 15,549,553(+) CTCAC(A/G)CCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC16 Gene

Variant ID Type Subtype PubMed ID
nsv833536 CNV loss 17160897

Variation tolerance for DNAJC16 Gene

Residual Variation Intolerance Score: 33.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC16 Gene

Disorders for DNAJC16 Gene

Relevant External Links for DNAJC16

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DNAJC16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC16 Gene

Publications for DNAJC16 Gene

  1. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 46 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4 64

Products for DNAJC16 Gene

Sources for DNAJC16 Gene

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