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Aliases for DNAJC16 Gene

Aliases for DNAJC16 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C16 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 16 2
  • KIAA0962 4

External Ids for DNAJC16 Gene

Previous GeneCards Identifiers for DNAJC16 Gene

  • GC01P015599
  • GC01P015725
  • GC01P015853
  • GC01P014372

Summaries for DNAJC16 Gene

GeneCards Summary for DNAJC16 Gene

DNAJC16 (DnaJ Heat Shock Protein Family (Hsp40) Member C16) is a Protein Coding gene. An important paralog of this gene is DNAJB14.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC16 Gene

Genomics for DNAJC16 Gene

Regulatory Elements for DNAJC16 Gene

Enhancers for DNAJC16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F015543 0.4 ENCODE 10.4 +17.0 16998 1.1 HDGF PKNOX1 ATF1 ARNT CREB3L1 ZNF121 GATA2 FOS JUNB NCOA1 AGMAT ENSG00000237938 FBXO42 SPEN DNAJC16 RPS16P1 ENSG00000251866 PIR45878 GC01P015565
GH01F015678 0.9 FANTOM5 ENCODE 10.2 +155.5 155545 8.0 HDGF PKNOX1 ARNT SIN3A ARID4B ZNF2 ZNF766 ZNF143 ZNF207 ZNF548 PLEKHM2 SPEN RPL22P3 CASP9 SLC25A34 ENSG00000237938 RPS16P1 ZBTB17 DNAJC16 AGMAT
GH01F015258 1.1 FANTOM5 Ensembl ENCODE 10.1 -266.5 -266513 4.6 HDGF PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 ZNF143 ZNF207 SPEN ENSG00000237938 FHAD1 LOC101927417 ENSG00000224621 PLEKHM2 RPS16P1 DNAJC16 TMEM51 EFHD2
GH01F015248 1.4 FANTOM5 Ensembl ENCODE 10.1 -277.7 -277727 1.0 PKNOX1 ZFP64 RAD21 YY1 ZNF121 ZNF354C KLF7 CREM ZNF680 ZNF654 SPEN ENSG00000237938 RPS16P1 FHAD1 LOC101927417 ENSG00000224621 DNAJC16 TMEM51 PLEKHM2 EFHD2
GH01F014994 0.8 Ensembl ENCODE 10.1 -530.3 -530313 3.4 HDGF ATF1 PKNOX1 ZFP64 ZNF493 ZNF121 ZNF766 ZNF302 GATA2 ZNF143 SPEN ENSG00000237938 RPS16P1 ZBTB17 DNAJC16 PIR50978 LOC105376758
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DNAJC16 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJC16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001577216 187 2001 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for DNAJC16 Gene

Chromosome:
1
Start:
15,526,813 bp from pter
End:
15,592,379 bp from pter
Size:
65,567 bases
Orientation:
Plus strand

Genomic View for DNAJC16 Gene

Genes around DNAJC16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC16 Gene

Proteins for DNAJC16 Gene

  • Protein details for DNAJC16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2G8-DJC16_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 16
    Protein Accession:
    Q9Y2G8
    Secondary Accessions:
    • Q68D57
    • Q86X32
    • Q8N5P4

    Protein attributes for DNAJC16 Gene

    Size:
    782 amino acids
    Molecular mass:
    90591 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76806.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAJC16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJC16 Gene

Post-translational modifications for DNAJC16 Gene

  • Glycosylation at Asn 631
  • Modification sites at PhosphoSitePlus

Other Protein References for DNAJC16 Gene

No data available for DME Specific Peptides for DNAJC16 Gene

Domains & Families for DNAJC16 Gene

Gene Families for DNAJC16 Gene

Protein Domains for DNAJC16 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2G8

UniProtKB/Swiss-Prot:

DJC16_HUMAN :
  • Contains 1 J domain.
Domain:
  • Contains 1 J domain.
  • Contains 1 thioredoxin domain.
genes like me logo Genes that share domains with DNAJC16: view

Function for DNAJC16 Gene

genes like me logo Genes that share phenotypes with DNAJC16: view

Animal Models for DNAJC16 Gene

MGI Knock Outs for DNAJC16:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DNAJC16 Gene

Localization for DNAJC16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC16 Gene

Membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJC16 Gene COMPARTMENTS Subcellular localization image for DNAJC16 gene
Compartment Confidence
endoplasmic reticulum 3
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DNAJC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DNAJC16: view

Pathways & Interactions for DNAJC16 Gene

SuperPathways for DNAJC16 Gene

No Data Available

Interacting Proteins for DNAJC16 Gene

Gene Ontology (GO) - Biological Process for DNAJC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with DNAJC16: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJC16 Gene

Transcripts for DNAJC16 Gene

Unigene Clusters for DNAJC16 Gene

DnaJ (Hsp40) homolog, subfamily C, member 16:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC16 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16a ·
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8:

ExUns: 16b · 16c ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -

Relevant External Links for DNAJC16 Gene

GeneLoc Exon Structure for
DNAJC16
ECgene alternative splicing isoforms for
DNAJC16

Expression for DNAJC16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DNAJC16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJC16 Gene

This gene is overexpressed in Cerebrospinal fluid (51.8) and Peripheral blood mononuclear cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNAJC16 Gene



Protein tissue co-expression partners for DNAJC16 Gene

NURSA nuclear receptor signaling pathways regulating expression of DNAJC16 Gene:

DNAJC16

SOURCE GeneReport for Unigene cluster for DNAJC16 Gene:

Hs.655410
genes like me logo Genes that share expression patterns with DNAJC16: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DNAJC16 Gene

Orthologs for DNAJC16 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNAJC16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC16 34 35
  • 99.57 (n)
cow
(Bos Taurus)
Mammalia DNAJC16 34 35
  • 90.2 (n)
dog
(Canis familiaris)
Mammalia DNAJC16 34 35
  • 89.94 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 89 (a)
OneToMany
-- 35
  • 86 (a)
OneToMany
-- 35
  • 84 (a)
OneToMany
-- 35
  • 82 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia DNAJC16 35
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajc16 34
  • 85.04 (n)
mouse
(Mus musculus)
Mammalia Dnajc16 34 16 35
  • 83.25 (n)
chicken
(Gallus gallus)
Aves DNAJC16 34 35
  • 73.19 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488071 34
  • 68.28 (n)
zebrafish
(Danio rerio)
Actinopterygii dnajc16 34
  • 61.42 (n)
DNAJC16 (1 of 2) 35
  • 60 (a)
OneToMany
DNAJC16 (2 of 2) 35
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG40178 34 35
  • 43.88 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001070 34
  • 43.75 (n)
worm
(Caenorhabditis elegans)
Secernentea dnj-8 34 35
  • 42.74 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HLJ1 35
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToOne
Species where no ortholog for DNAJC16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC16 Gene

ENSEMBL:
Gene Tree for DNAJC16 (if available)
TreeFam:
Gene Tree for DNAJC16 (if available)

Paralogs for DNAJC16 Gene

Paralogs for DNAJC16 Gene

(3) SIMAP similar genes for DNAJC16 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DNAJC16: view

Variants for DNAJC16 Gene

Sequence variations from dbSNP and Humsavar for DNAJC16 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10803389 -- 15,534,792(+) CAGCT(C/T)TTGGA intron-variant
rs10803390 -- 15,538,923(+) CATTC(A/G)AGTGG intron-variant
rs10803391 -- 15,550,083(+) AAGTA(A/G)GGCCA intron-variant
rs10803392 -- 15,550,263(+) TCTTT(C/T)GGAAC intron-variant
rs10927796 -- 15,530,639(+) TCTAT(A/G)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC16 Gene

Variant ID Type Subtype PubMed ID
nsv833536 CNV loss 17160897

Variation tolerance for DNAJC16 Gene

Residual Variation Intolerance Score: 33.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJC16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC16 Gene

Disorders for DNAJC16 Gene

Relevant External Links for DNAJC16

Genetic Association Database (GAD)
DNAJC16
Human Genome Epidemiology (HuGE) Navigator
DNAJC16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJC16

No disorders were found for DNAJC16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC16 Gene

Publications for DNAJC16 Gene

  1. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 46 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4 64

Products for DNAJC16 Gene

Sources for DNAJC16 Gene

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