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Aliases for DNAJC15 Gene

Aliases for DNAJC15 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C15 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 15 2 3
  • DnaJ (Hsp40) Homolog, Subfamily D, Member 1 2 3
  • Cell Growth-Inhibiting Gene 22 Protein 3 4
  • Methylation-Controlled J Protein 3 4
  • DNAJD1 3 4
  • MCJ 3 4
  • DnaJ Homolog Subfamily C Member 15 3
  • DNAJ Domain-Containing 3
  • HSD18 3

External Ids for DNAJC15 Gene

Previous HGNC Symbols for DNAJC15 Gene

  • DNAJD1

Previous GeneCards Identifiers for DNAJC15 Gene

  • GC13P042496
  • GC13P043597
  • GC13P024399

Summaries for DNAJC15 Gene

GeneCards Summary for DNAJC15 Gene

DNAJC15 (DnaJ Heat Shock Protein Family (Hsp40) Member C15) is a Protein Coding gene. Diseases associated with DNAJC15 include Cicatricial Entropion. An important paralog of this gene is DNAJC19.

UniProtKB/Swiss-Prot for DNAJC15 Gene

  • Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC15 Gene

Genomics for DNAJC15 Gene

Regulatory Elements for DNAJC15 Gene

Enhancers for DNAJC15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F043022 0.2 ENCODE 78.8 +0.5 471 2.3 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF143 SP5 MXD4 REST DNAJC15 EPSTI1 AKAP11 GC13P043024
GH13F043039 1.4 FANTOM5 Ensembl ENCODE 60.7 +19.9 19941 6.9 ELF3 PKNOX1 TBL1XR1 BMI1 ZSCAN9 YY1 CBX5 SCRT2 ETV6 CREM DNAJC15 EPSTI1 TNFSF11 GC13P043043 GC13P043024
GH13F043048 1.4 FANTOM5 Ensembl ENCODE 45.4 +26.5 26498 1.8 IKZF1 JUNB MLLT1 ETV6 NFE2 DNAJC15 EPSTI1 GC13M043046 GC13P043094
GH13F043053 1 Ensembl ENCODE 43.8 +34.8 34771 9.0 HDGF PKNOX1 ATF1 MLX SIN3A FEZF1 GLIS2 KLF7 FOS SP3 DNAJC15 EPSTI1 CCDC122 GC13M043046 GC13P043094
GH13F043070 0.5 ENCODE 43.8 +48.8 48808 3.0 TEAD4 CEBPB ZNF384 CEBPG MAFF ZNF316 CEBPA MAFK EMSY DNAJC15 CCDC122 GC13P043094 GC13M043046
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DNAJC15 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJC15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000055134 797 2001 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF143 SP5 MXD4 REST

Genomic Location for DNAJC15 Gene

Chromosome:
13
Start:
43,023,203 bp from pter
End:
43,114,224 bp from pter
Size:
91,022 bases
Orientation:
Plus strand

Genomic View for DNAJC15 Gene

Genes around DNAJC15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC15 Gene

Proteins for DNAJC15 Gene

  • Protein details for DNAJC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5T4-DJC15_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 15
    Protein Accession:
    Q9Y5T4
    Secondary Accessions:
    • B2R4L0
    • Q5T219
    • Q6X963

    Protein attributes for DNAJC15 Gene

    Size:
    150 amino acids
    Molecular mass:
    16383 Da
    Quaternary structure:
    • Interacts with the TIM23 complex. Directly interacts with PAM16/MAGMAS; this interaction counteracts DNAJC15-dependent stimulation of HSPA9 ATPase activity. Associates with complex I of the mitochondrial electron transfer chain; this interaction may interfere with the formation of supercomplexes that facilitate the transfer of electrons between complexes (By similarity).

neXtProt entry for DNAJC15 Gene

Post-translational modifications for DNAJC15 Gene

  • Glycosylation at Ser 104
  • Modification sites at PhosphoSitePlus

Other Protein References for DNAJC15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJC15 Gene

Domains & Families for DNAJC15 Gene

Gene Families for DNAJC15 Gene

Protein Domains for DNAJC15 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DNAJC15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5T4

UniProtKB/Swiss-Prot:

DJC15_HUMAN :
  • Contains 1 J domain.
Domain:
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJC15: view

Function for DNAJC15 Gene

Molecular function for DNAJC15 Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9.

Gene Ontology (GO) - Molecular Function for DNAJC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DNAJC15: view
genes like me logo Genes that share phenotypes with DNAJC15: view

Animal Models for DNAJC15 Gene

MGI Knock Outs for DNAJC15:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DNAJC15 Gene

Localization for DNAJC15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC15 Gene

Mitochondrion inner membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJC15 Gene COMPARTMENTS Subcellular localization image for DNAJC15 gene
Compartment Confidence
mitochondrion 4
cytosol 3
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DNAJC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DNAJC15: view

Pathways & Interactions for DNAJC15 Gene

SuperPathways for DNAJC15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0009267 cellular response to starvation IEA --
GO:0015031 protein transport IEA --
GO:0019216 regulation of lipid metabolic process IEA --
GO:0031333 negative regulation of protein complex assembly IEA --
genes like me logo Genes that share ontologies with DNAJC15: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJC15 Gene

Transcripts for DNAJC15 Gene

mRNA/cDNA for DNAJC15 Gene

Unigene Clusters for DNAJC15 Gene

DnaJ (Hsp40) homolog, subfamily C, member 15:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC15 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1: - - -
SP2:

Relevant External Links for DNAJC15 Gene

GeneLoc Exon Structure for
DNAJC15
ECgene alternative splicing isoforms for
DNAJC15

Expression for DNAJC15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DNAJC15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJC15 Gene

This gene is overexpressed in Bone (32.8) and Pancreatic juice (32.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNAJC15 Gene



Protein tissue co-expression partners for DNAJC15 Gene

NURSA nuclear receptor signaling pathways regulating expression of DNAJC15 Gene:

DNAJC15

SOURCE GeneReport for Unigene cluster for DNAJC15 Gene:

Hs.438830

mRNA Expression by UniProt/SwissProt for DNAJC15 Gene:

Q9Y5T4-DJC15_HUMAN
Tissue specificity: Expressed at highest levels in heart, followed by liver and kidney.
genes like me logo Genes that share expression patterns with DNAJC15: view

Primer Products

No data available for mRNA differential expression in normal tissues for DNAJC15 Gene

Orthologs for DNAJC15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJC15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC15 34 35
  • 99.33 (n)
dog
(Canis familiaris)
Mammalia DNAJC15 34 35
  • 91.06 (n)
cow
(Bos Taurus)
Mammalia DNAJC15 34 35
  • 87.02 (n)
mouse
(Mus musculus)
Mammalia Dnajc15 34 16 35
  • 85.64 (n)
rat
(Rattus norvegicus)
Mammalia Dnajc15 34
  • 84.43 (n)
oppossum
(Monodelphis domestica)
Mammalia DNAJC15 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJC15 34 35
  • 77.54 (n)
lizard
(Anolis carolinensis)
Reptilia DNAJC15 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc15 34
  • 73.24 (n)
zebrafish
(Danio rerio)
Actinopterygii dnajc15 34 35
  • 61.38 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7394 35
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dnj-21 35
  • 55 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAM18 35
  • 26 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os03g0776900 34
  • 54.3 (n)
Species where no ortholog for DNAJC15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC15 Gene

ENSEMBL:
Gene Tree for DNAJC15 (if available)
TreeFam:
Gene Tree for DNAJC15 (if available)

Paralogs for DNAJC15 Gene

Paralogs for DNAJC15 Gene

(1) SIMAP similar genes for DNAJC15 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for DNAJC15 Gene

genes like me logo Genes that share paralogs with DNAJC15: view

Variants for DNAJC15 Gene

Sequence variations from dbSNP and Humsavar for DNAJC15 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1028732 -- 43,063,531(+) ttctg(G/T)tgtta intron-variant
rs1028733 -- 43,063,671(+) tatta(C/T)taatt intron-variant
rs1028734 -- 43,063,861(+) CATAT(G/T)AAATA intron-variant
rs1028735 -- 43,064,635(+) aagat(A/G)gaact intron-variant
rs1047762 -- 43,107,261(+) GGACC(A/C)CACTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DNAJC15 Gene

Variant ID Type Subtype PubMed ID
dgv109n21 CNV gain 19592680
dgv1637n100 CNV gain 25217958
dgv1639n100 CNV gain 25217958
dgv1641n100 CNV gain 25217958
dgv3129n54 CNV gain 21841781
dgv3131n54 CNV gain 21841781
dgv324n67 CNV gain 20364138
dgv329e214 CNV gain 21293372
dgv330e214 CNV gain 21293372
dgv81n111 CNV duplication 26073780
esv2421588 CNV duplication 20811451
esv2672540 CNV deletion 23128226
esv2678627 CNV deletion 23128226
esv2747322 CNV deletion 23290073
esv2751145 CNV gain 17911159
esv29187 CNV gain 19812545
esv33538 CNV gain 17666407
esv3375246 CNV insertion 20981092
esv3631913 CNV loss 21293372
esv3631914 CNV loss 21293372
esv3631915 CNV loss 21293372
esv3892335 CNV gain 25118596
nsv1160111 CNV duplication 26073780
nsv442669 CNV gain 18776908
nsv455873 CNV loss 19166990
nsv514696 CNV gain 21397061
nsv519830 CNV loss 19592680
nsv524787 CNV gain 19592680
nsv525534 CNV gain 19592680
nsv561552 CNV gain 21841781
nsv561567 CNV gain 21841781
nsv818960 CNV gain 17921354
nsv819470 CNV gain 19587683

Variation tolerance for DNAJC15 Gene

Residual Variation Intolerance Score: 63.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.63; 72.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJC15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC15 Gene

Disorders for DNAJC15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DNAJC15 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cicatricial entropion
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

DJC15_HUMAN
  • Note=Absent or down-regulated in many advanced cases of ovarian adenocarcinoma, due to hypermethylation and allelic loss. Loss of expression correlates with increased resistance to antineoplastic drugs, such as cisplatin. {ECO:0000269 PubMed:11358853}.

Relevant External Links for DNAJC15

Genetic Association Database (GAD)
DNAJC15
Human Genome Epidemiology (HuGE) Navigator
DNAJC15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJC15
genes like me logo Genes that share disorders with DNAJC15: view

No data available for Genatlas for DNAJC15 Gene

Publications for DNAJC15 Gene

  1. Loss of expression of a new member of the DNAJ protein family confers resistance to chemotherapeutic agents used in the treatment of ovarian cancer. (PMID: 11358853) Shridhar V. … Smith D.I. (Cancer Res. 2001) 2 3 4 64
  2. Methylation-controlled J-protein MCJ acts in the import of proteins into human mitochondria. (PMID: 23263864) Schusdziarra C. … Hell K. (Hum. Mol. Genet. 2013) 3 4 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need A.C. … Goldstein D.B. (Hum. Mol. Genet. 2009) 3 46 64
  5. Methylation-controlled J protein promotes c-Jun degradation to prevent ABCB1 transporter expression. (PMID: 17283040) Hatle K.M. … RincA^n M. (Mol. Cell. Biol. 2007) 3 22 64

Products for DNAJC15 Gene

Sources for DNAJC15 Gene

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