Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DNAJC15 Gene

Aliases for DNAJC15 Gene

  • DnaJ (Hsp40) Homolog, Subfamily C, Member 15 2 3
  • DnaJ (Hsp40) Homolog, Subfamily D, Member 1 2 3
  • Cell Growth-Inhibiting Gene 22 Protein 3 4
  • Methylation-Controlled J Protein 3 4
  • DNAJD1 3 4
  • MCJ 3 4
  • DNAJ Domain-Containing 3
  • HSD18 3

External Ids for DNAJC15 Gene

Previous HGNC Symbols for DNAJC15 Gene

  • DNAJD1

Previous GeneCards Identifiers for DNAJC15 Gene

  • GC13P042496
  • GC13P043597
  • GC13P024399

Summaries for DNAJC15 Gene

GeneCards Summary for DNAJC15 Gene

DNAJC15 (DnaJ (Hsp40) Homolog, Subfamily C, Member 15) is a Protein Coding gene. Diseases associated with DNAJC15 include cicatricial entropion. An important paralog of this gene is DNAJC19.

UniProtKB/Swiss-Prot for DNAJC15 Gene

  • Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC15 Gene

Genomics for DNAJC15 Gene

Regulatory Elements for DNAJC15 Gene

Genomic Location for DNAJC15 Gene

Chromosome:
13
Start:
43,023,203 bp from pter
End:
43,114,224 bp from pter
Size:
91,022 bases
Orientation:
Plus strand

Genomic View for DNAJC15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for DNAJC15 Gene

Proteins for DNAJC15 Gene

  • Protein details for DNAJC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5T4-DJC15_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 15
    Protein Accession:
    Q9Y5T4
    Secondary Accessions:
    • B2R4L0
    • Q5T219
    • Q6X963

    Protein attributes for DNAJC15 Gene

    Size:
    150 amino acids
    Molecular mass:
    16383 Da
    Quaternary structure:
    • Interacts with the TIM23 complex. Directly interacts with PAM16/MAGMAS; this interaction counteracts DNAJC15-dependent stimulation of HSPA9 ATPase activity. Associates with complex I of the mitochondrial electron transfer chain; this interaction may interfere with the formation of supercomplexes that facilitate the transfer of electrons between complexes (By similarity).

neXtProt entry for DNAJC15 Gene

Proteomics data for DNAJC15 Gene at MOPED

Post-translational modifications for DNAJC15 Gene

  • Glycosylation at Ser 104
  • Modification sites at PhosphoSitePlus

Other Protein References for DNAJC15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJC15 Gene

Domains & Families for DNAJC15 Gene

Gene Families for DNAJC15 Gene

Protein Domains for DNAJC15 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DNAJC15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5T4

UniProtKB/Swiss-Prot:

DJC15_HUMAN :
  • Contains 1 J domain.
Domain:
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJC15: view

Function for DNAJC15 Gene

Molecular function for DNAJC15 Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9.

Gene Ontology (GO) - Molecular Function for DNAJC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0008565 contributes_to protein transporter activity IBA --
genes like me logo Genes that share ontologies with DNAJC15: view
genes like me logo Genes that share phenotypes with DNAJC15: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJC15

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJC15 Gene

Localization for DNAJC15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC15 Gene

Mitochondrion inner membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJC15 Gene COMPARTMENTS Subcellular localization image for DNAJC15 gene
Compartment Confidence
mitochondrion 3
cytosol 2

Gene Ontology (GO) - Cellular Components for DNAJC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001405 presequence translocase-associated import motor IBA --
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DNAJC15: view

Pathways & Interactions for DNAJC15 Gene

SuperPathways for DNAJC15 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DNAJC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009267 cellular response to starvation IEA --
GO:0019216 regulation of lipid metabolic process IEA --
GO:0030150 protein import into mitochondrial matrix IBA --
GO:0031333 negative regulation of protein complex assembly IEA --
GO:0032781 positive regulation of ATPase activity IBA --
genes like me logo Genes that share ontologies with DNAJC15: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJC15 Gene

Drugs & Compounds for DNAJC15 Gene

No Compound Related Data Available

Transcripts for DNAJC15 Gene

mRNA/cDNA for DNAJC15 Gene

Unigene Clusters for DNAJC15 Gene

DnaJ (Hsp40) homolog, subfamily C, member 15:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJC15

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC15 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1: - - -
SP2:

Relevant External Links for DNAJC15 Gene

GeneLoc Exon Structure for
DNAJC15
ECgene alternative splicing isoforms for
DNAJC15

Expression for DNAJC15 Gene

mRNA expression in normal human tissues for DNAJC15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJC15 Gene

This gene is overexpressed in Bone (32.8) and Pancreatic juice (32.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJC15 Gene



SOURCE GeneReport for Unigene cluster for DNAJC15 Gene Hs.438830

mRNA Expression by UniProt/SwissProt for DNAJC15 Gene

Q9Y5T4-DJC15_HUMAN
Tissue specificity: Expressed at highest levels in heart, followed by liver and kidney.
genes like me logo Genes that share expression patterns with DNAJC15: view

Protein tissue co-expression partners for DNAJC15 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DNAJC15 Gene

Orthologs for DNAJC15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJC15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNAJC15 35
  • 87.02 (n)
  • 81.21 (a)
DNAJC15 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJC15 35
  • 91.06 (n)
  • 84.06 (a)
DNAJC15 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajc15 35
  • 85.64 (n)
  • 81.75 (a)
Dnajc15 16
Dnajc15 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DNAJC15 35
  • 99.33 (n)
  • 98.67 (a)
DNAJC15 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajc15 35
  • 84.43 (n)
  • 82.48 (a)
oppossum
(Monodelphis domestica)
Mammalia DNAJC15 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJC15 35
  • 77.54 (n)
  • 74.64 (a)
DNAJC15 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJC15 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc15 35
  • 73.24 (n)
  • 72.99 (a)
zebrafish
(Danio rerio)
Actinopterygii dnajc15 35
  • 61.38 (n)
  • 63.45 (a)
dnajc15 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7394 36
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dnj-21 36
  • 55 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAM18 36
  • 26 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os03g0776900 35
  • 54.3 (n)
  • 51.55 (a)
Species with no ortholog for DNAJC15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC15 Gene

ENSEMBL:
Gene Tree for DNAJC15 (if available)
TreeFam:
Gene Tree for DNAJC15 (if available)

Paralogs for DNAJC15 Gene

Paralogs for DNAJC15 Gene

(1) SIMAP similar genes for DNAJC15 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for DNAJC15 Gene

genes like me logo Genes that share paralogs with DNAJC15: view

Variants for DNAJC15 Gene

Sequence variations from dbSNP and Humsavar for DNAJC15 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
VAR_027077 -

Structural Variations from Database of Genomic Variants (DGV) for DNAJC15 Gene

Variant ID Type Subtype PubMed ID
esv33538 CNV Gain 17666407
dgv1575n71 CNV Gain 21882294
nsv900022 CNV Gain 21882294
nsv900023 CNV Gain 21882294
nsv455873 CNV Loss 19166990
nsv519830 CNV Loss 19592680
nsv525534 CNV Gain 19592680
dgv324n67 CNV Gain 20364138
nsv819470 CNV Gain 19587683
esv2421588 CNV Duplication 20811451
esv29187 CNV Gain 19812545
nsv442669 CNV CNV 18776908
nsv514696 CNV Gain 21397061
dgv109n21 CNV Gain 19592680
nsv524787 CNV Gain 19592680
nsv818960 CNV Gain 17921354
esv2747322 CNV Deletion 23290073
esv2672540 CNV Deletion 23128226
esv2678627 CNV Deletion 23128226
esv2751145 CNV Gain 17911159

Variation tolerance for DNAJC15 Gene

Residual Variation Intolerance Score: 63.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.63; 72.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC15 Gene

HapMap Linkage Disequilibrium report
DNAJC15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC15 Gene

Disorders for DNAJC15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DNAJC15 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cicatricial entropion
- elite association

UniProtKB/Swiss-Prot

DJC15_HUMAN
  • Note=Absent or down-regulated in many advanced cases of ovarian adenocarcinoma, due to hypermethylation and allelic loss. Loss of expression correlates with increased resistance to antineoplastic drugs, such as cisplatin.

Relevant External Links for DNAJC15

Genetic Association Database (GAD)
DNAJC15
Human Genome Epidemiology (HuGE) Navigator
DNAJC15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJC15
genes like me logo Genes that share disorders with DNAJC15: view

No data available for Genatlas for DNAJC15 Gene

Publications for DNAJC15 Gene

  1. Methylation-controlled J protein promotes c-Jun degradation to prevent ABCB1 transporter expression. (PMID: 17283040) Hatle K.M. … RincA^n M. (Mol. Cell. Biol. 2007) 23 67
  2. Loss of expression of a new member of the DNAJ protein family confers resistance to chemotherapeutic agents used in the treatment of ovarian cancer. (PMID: 11358853) Shridhar V. … Smith D.I. (Cancer Res. 2001) 2 67
  3. The expression of CCN2, IQSEC, RSPO1, DNAJC15, RIPK2, IL13RA2, IRS1, and IRS2 genes in blood of obese boys with insulin resistance. (PMID: 26040030) Minchenko D.O. … Minchenko O.H. (Fiziol Zh 2015) 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. Chaperoning mitochondrial permeability transition: regulation of transition pore complex by a J-protein, DnaJC15. (PMID: 24603329) Sinha D. … D'Silva P. (Cell Death Dis 2014) 67

Products for DNAJC15 Gene

Sources for DNAJC15 Gene

Back to Top

Content