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Aliases for DNAJC15 Gene

Aliases for DNAJC15 Gene

  • DnaJ (Hsp40) Homolog, Subfamily C, Member 15 2 3
  • MCJ 3 4 6
  • DnaJ (Hsp40) Homolog, Subfamily D, Member 1 2 3
  • Cell Growth-Inhibiting Gene 22 Protein 3 4
  • Methylation-Controlled J Protein 3 4
  • DNAJD1 3 4
  • DnaJ Homolog Subfamily C Member 15 3
  • DNAJ Domain-Containing 3
  • HSD18 3

External Ids for DNAJC15 Gene

Previous Symbols for DNAJC15 Gene

  • DNAJD1

Summaries for DNAJC15 Gene

GeneCards Summary for DNAJC15 Gene

DNAJC15 (DnaJ (Hsp40) Homolog, Subfamily C, Member 15) is a Protein Coding gene. Diseases associated with DNAJC15 include cicatricial entropion and entropion. An important paralog of this gene is DNAJC19.

UniProtKB/Swiss-Prot for DNAJC15 Gene

  • Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC15 Gene

Genomics for DNAJC15 Gene

Genomic Location for DNAJC15 Gene

Start:
43,023,203 bp from pter
End:
43,114,224 bp from pter
Size:
91,022 bases
Orientation:
Plus strand

Genomic View for DNAJC15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJC15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC15 Gene

Regulatory Elements for DNAJC15 Gene

Proteins for DNAJC15 Gene

  • Protein details for DNAJC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5T4-DJC15_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 15
    Protein Accession:
    Q9Y5T4
    Secondary Accessions:
    • B2R4L0
    • Q5T219
    • Q6X963

    Protein attributes for DNAJC15 Gene

    Size:
    150 amino acids
    Molecular mass:
    16383 Da
    Quaternary structure:
    • Interacts with the TIM23 complex. Directly interacts with PAM16/MAGMAS; this interaction counteracts DNAJC15-dependent stimulation of HSPA9 ATPase activity. Associates with complex I of the mitochondrial electron transfer chain; this interaction may interfere with the formation of supercomplexes that facilitate the transfer of electrons between complexes (By similarity).

neXtProt entry for DNAJC15 Gene

Proteomics data for DNAJC15 Gene at MOPED

Post-translational modifications for DNAJC15 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Ser104 and Ser106

Other Protein References for DNAJC15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJC15 Gene

Domains for DNAJC15 Gene

Gene Families for DNAJC15 Gene

HGNC:
  • DNAJ :Heat shock proteins / DNAJ (HSP40)

Protein Domains for DNAJC15 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

DJC15_HUMAN
Domain:
  • Contains 1 J domain.:
    • Q9Y5T4
genes like me logo Genes that share domains with DNAJC15: view

Function for DNAJC15 Gene

Molecular function for DNAJC15 Gene

UniProtKB/Swiss-Prot Function: Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9.

Gene Ontology (GO) - Molecular Function for DNAJC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DNAJC15: view
genes like me logo Genes that share phenotypes with DNAJC15: view

miRNA for DNAJC15 Gene

miRTarBase miRNAs that target DNAJC15

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DNAJC15 Gene

Localization for DNAJC15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC15 Gene

Mitochondrion inner membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJC15 Gene COMPARTMENTS Subcellular localization image for DNAJC15 gene
Compartment Confidence
cytosol 2
mitochondrion 2
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DNAJC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DNAJC15: view

Pathways for DNAJC15 Gene

SuperPathways for DNAJC15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009267 cellular response to starvation IEA --
GO:0015031 protein transport IEA --
GO:0019216 regulation of lipid metabolic process IEA --
GO:0031333 negative regulation of protein complex assembly IEA --
GO:1902957 negative regulation of mitochondrial electron transport, NADH to ubiquinone IEA --
genes like me logo Genes that share ontologies with DNAJC15: view

No data available for Pathways by source for DNAJC15 Gene

Transcripts for DNAJC15 Gene

mRNA/cDNA for DNAJC15 Gene

Unigene Clusters for DNAJC15 Gene

DnaJ (Hsp40) homolog, subfamily C, member 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC15 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1: - - -
SP2:

Relevant External Links for DNAJC15 Gene

GeneLoc Exon Structure for
DNAJC15
ECgene alternative splicing isoforms for
DNAJC15

Expression for DNAJC15 Gene

mRNA expression in normal human tissues for DNAJC15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJC15 Gene

SOURCE GeneReport for Unigene cluster for DNAJC15 Gene Hs.438830

mRNA Expression by UniProt/SwissProt for DNAJC15 Gene

Q9Y5T4-DJC15_HUMAN
Tissue specificity: Expressed at highest levels in heart, followed by liver and kidney.
genes like me logo Genes that share expressions with DNAJC15: view

Orthologs for DNAJC15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJC15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC15 36
  • 99.33 (n)
  • 98.67 (a)
DNAJC15 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAJC15 36
  • 87.02 (n)
  • 81.21 (a)
DNAJC15 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJC15 36
  • 91.06 (n)
  • 84.06 (a)
DNAJC15 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajc15 36
  • 85.64 (n)
  • 81.75 (a)
Dnajc15 16
Dnajc15 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNAJC15 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajc15 36
  • 84.43 (n)
  • 82.48 (a)
chicken
(Gallus gallus)
Aves DNAJC15 36
  • 77.54 (n)
  • 74.64 (a)
DNAJC15 37
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJC15 37
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc15 36
  • 73.24 (n)
  • 72.99 (a)
zebrafish
(Danio rerio)
Actinopterygii dnajc15 36
  • 61.38 (n)
  • 63.45 (a)
dnajc15 37
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7394 37
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dnj-21 37
  • 55 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAM18 37
  • 26 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os03g0776900 36
  • 54.3 (n)
  • 51.55 (a)
Species with no ortholog for DNAJC15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC15 Gene

ENSEMBL:
Gene Tree for DNAJC15 (if available)
TreeFam:
Gene Tree for DNAJC15 (if available)

Paralogs for DNAJC15 Gene

Paralogs for DNAJC15 Gene

Selected SIMAP similar genes for DNAJC15 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for DNAJC15 Gene

genes like me logo Genes that share paralogs with DNAJC15: view

Variants for DNAJC15 Gene

Sequence variations from dbSNP and Humsavar for DNAJC15 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs11346 -- 43,108,884(+) ATAAA(A/G)TATAT utr-variant-3-prime
rs11728 -- 43,108,872(+) ACCTT(A/G)AAGTC utr-variant-3-prime
rs12015 -- 43,023,729(-) CAGTC(C/T)CTGCT reference, missense
rs879051 -- 43,086,642(+) TTTTC(G/T)CTAAG intron-variant
rs879052 -- 43,086,731(+) CTAAA(A/G)ATTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC15 Gene

Variant ID Type Subtype PubMed ID
esv33538 CNV Gain 17666407
dgv1575n71 CNV Gain 21882294
nsv900022 CNV Gain 21882294
nsv900023 CNV Gain 21882294
nsv455873 CNV Loss 19166990
nsv519830 CNV Loss 19592680
nsv525534 CNV Gain 19592680
dgv324n67 CNV Gain 20364138
nsv819470 CNV Gain 19587683
esv2421588 CNV Duplication 20811451
esv29187 CNV Gain 19812545
nsv442669 CNV CNV 18776908
nsv514696 CNV Gain 21397061
dgv109n21 CNV Gain 19592680
nsv524787 CNV Gain 19592680
nsv818960 CNV Gain 17921354
esv2747322 CNV Deletion 23290073
esv2672540 CNV Deletion 23128226
esv2678627 CNV Deletion 23128226
esv2751145 CNV Gain 17911159

Relevant External Links for DNAJC15 Gene

HapMap Linkage Disequilibrium report
DNAJC15

Disorders for DNAJC15 Gene

UniProtKB/Swiss-Prot

DJC15_HUMAN
  • Note=Absent or down-regulated in many advanced cases of ovarian adenocarcinoma, due to hypermethylation and allelic loss. Loss of expression correlates with increased resistance to antineoplastic drugs, such as cisplatin.

(1) University of Copenhagen DISEASES for DNAJC15 Gene

Relevant External Links for DNAJC15

Genetic Association Database (GAD)
DNAJC15
Human Genome Epidemiology (HuGE) Navigator
DNAJC15
genes like me logo Genes that share disorders with DNAJC15: view

Publications for DNAJC15 Gene

  1. Loss of expression of a new member of the DNAJ protein family confers resistance to chemotherapeutic agents used in the treatment of ovarian cancer. (PMID: 11358853) Shridhar V. … Smith D.I. (Cancer Res. 2001) 2 3 4
  2. Methylation-controlled J protein promotes c-Jun degradation to prevent ABCB1 transporter expression. (PMID: 17283040) Hatle K.M. … RincA^n M. (Mol. Cell. Biol. 2007) 3 23
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need A.C. … Goldstein D.B. (Hum. Mol. Genet. 2009) 3 49

Products for DNAJC15 Gene

Sources for DNAJC15 Gene

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