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DNAJC14 Gene

protein-coding   GIFtS: 46
GCID: GC12M056214

DnaJ (Hsp40) Homolog, Subfamily C, Member 14

  See DNAJC14-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DnaJ (Hsp40) Homolog, Subfamily C, Member 141 2     hDj-32 3
DRIP782 3 5     DNAJ2
HDJ32 3 5     LIP62
DnaJ Protein Homolog 32 3     DnaJ Homolog Subfamily C Member 142
Dopamine Receptor-Interacting Protein Of 78 KDa2 3     Dopamine Receptor Interacting Protein2
Human DnaJ Protein 32 3     LYST-Interacting Protein LIP62

External Ids:    HGNC: 245811   Entrez Gene: 854062   Ensembl: ENSG000001353927   OMIM: 6060925   UniProtKB: Q6Y2X33   

Export aliases for DNAJC14 gene to outside databases

Previous GC identifers: GC12M054439 GC12M054440 GC12M054501 GC12M053253


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DNAJC14 Gene:
DNAJC14 (DnaJ (Hsp40) homolog, subfamily C, member 14) is a protein-coding gene. Diseases associated with DNAJC14 include bipolar disorder, and schizophrenia. An important paralog of this gene is ENSG00000257390.

UniProtKB/Swiss-Prot: DJC14_HUMAN, Q6Y2X3
Function: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell
surface (By similarity)

Gene Wiki entry for DNAJC14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the DNAJC14 gene promoter:
         STAT1   NF-1   STAT1beta   CUTL1   STAT1alpha   FOXJ2 (long isoform)   STAT2   FOXJ2   ZID   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJC14 promoter sequence
   Search Chromatin IP Primers for DNAJC14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAJC14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q12

DNAJC14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJC14 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M056214:  view genomic region     (about GC identifiers)

Start:
56,214,744 bp from pter      End:
56,224,608 bp from pter
Size:
9,865 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DJC14_HUMAN, Q6Y2X3 (See protein sequence)
Recommended Name: DnaJ homolog subfamily C member 14  
Size: 702 amino acids; 78569 Da
Subunit: Interacts with the FxxxFxxxF motif of DRD1 via its C-terminal domain (By similarity)
Sequence caution: Sequence=BAB71050.1; Type=Erroneous initiation;
Secondary accessions: A5YM67 Q17RY2 Q66K17 Q96N59 Q96T63

Explore the universe of human proteins at neXtProt for DNAJC14: NX_Q6Y2X3

Explore proteomics data for DNAJC14 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DNAJC14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115740.5  
    ENSEMBL proteins: 
     ENSP00000350223   ENSP00000317500   ENSP00000450196   ENSP00000448876   ENSP00000316240  

    DNAJC14 Human Recombinant Protein Products:

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    Novus Biologicals DNAJC14 Protein
    Novus Biologicals DNAJC14 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DNAJC14

     
    Search eBioscience for Proteins for DNAJC14 

     
    antibodies-online proteins for DNAJC14 

     
    antibodies-online peptides for DNAJC14

    DNAJC14 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for DNAJC14
    Cloud-Clone Corp. Antibodies for DNAJC14
    Search ThermoFisher Antibodies for DNAJC14
    antibodies-online antibodies for DNAJC14 (8 products) 

    DNAJC14 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for DNAJC14
    Cloud-Clone Corp. CLIAs for DNAJC14
    Search eBioscience for ELISAs for DNAJC14 
    antibodies-online kits for DNAJC14 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    1 InterPro protein domain:
     IPR001623 DnaJ_domain

    Graphical View of Domain Structure for InterPro Entry Q6Y2X3

    ProtoNet protein and cluster: Q6Y2X3

    UniProtKB/Swiss-Prot: DJC14_HUMAN, Q6Y2X3
    Similarity: Contains 1 J domain


    Find genes that share domains with DNAJC14           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DJC14_HUMAN, Q6Y2X3
    Function: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell
    surface (By similarity)

    Phenotypes:
         1 MGI phenotypic allele for Dnajc14 (no phenotypes)


    Find genes that share phenotypes with DNAJC14           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DNAJC14

    miRNA
    Products:
        
    miRTarBase miRNAs that target DNAJC14:
    hsa-mir-320a (MIRT044561), hsa-mir-378a-5p (MIRT043994)

    Block miRNA regulation of human, mouse, rat DNAJC14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAJC14 (see all 31):
    hsa-miR-3910 hsa-miR-495 hsa-miR-125a-5p hsa-miR-2909 hsa-miR-331-3p hsa-miR-548s hsa-miR-578 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidDNAJC14 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DNAJC14
    Predesigned siRNA for gene silencing in human, mouse, rat DNAJC14

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DNAJC14

    Clone
    Products:
         
    OriGene clones in human, mouse for DNAJC14 (see all 7)
    OriGene ORF clones in mouse, rat for DNAJC14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DNAJC14 (NM_032364)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJC14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC14

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for DNAJC14
    Browse ESI BIO Cell Lines and PureStem Progenitors for DNAJC14 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DJC14_HUMAN, Q6Y2X3: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus4
    cytosol3
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005730nucleolus ----
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with DNAJC14           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including DNAJC14: 
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DNAJC14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for DNAJC14 (Q6Y2X32, 3 ENSP000003162404) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX39BQ138382, 3MINT-62641 MINT-62739 MINT-62815 I2D: score=2 
    ENSG00000215425Q138382, 3MINT-62641 MINT-62739 MINT-62815 I2D: score=2 
    ENSG00000225073Q138382, 3MINT-62641 MINT-62739 MINT-62815 I2D: score=2 
    ENSG00000225859Q138382, 3MINT-62641 MINT-62739 MINT-62815 I2D: score=2 
    ENSG00000229496Q138382, 3MINT-62641 MINT-62739 MINT-62815 I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--

    Find genes that share ontologies with DNAJC14           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNAJC14 (DJC14)

    1 Novoseek inferred chemical compound relationship for DNAJC14 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dopamine 63.9 35 15364041 (3), 16462601 (3), 12496348 (2), 12967774 (2) (see all 12)



    Find genes that share compounds with DNAJC14           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DNAJC14 gene: 
    NM_032364.5  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357606 ENST00000317287(uc001shu.2 uc001shy.1) ENST00000547445
    ENST00000546957 ENST00000317269(uc001shx.1 uc009zob.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DNAJC14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAJC14 (see all 31):
    hsa-miR-3910 hsa-miR-495 hsa-miR-125a-5p hsa-miR-2909 hsa-miR-331-3p hsa-miR-548s hsa-miR-578 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidDNAJC14 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DNAJC14
    Predesigned siRNA for gene silencing in human, mouse, rat DNAJC14
    Clone
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    OriGene clones in human, mouse for DNAJC14 (see all 7)
    OriGene ORF clones in mouse, rat for DNAJC14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DNAJC14 (NM_032364)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJC14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC14
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DNAJC14
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJC14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAJC14
      QuantiTect SYBR Green Assays in human, mouse, rat DNAJC14
      QuantiFast Probe-based Assays in human, mouse, rat DNAJC14

    Selected AceView cDNA sequences (see all 543):

    BF058857 CA437028 BE463485 BI870282 AI688488 CA428644 BG754565 BE385556 
    BP872655 BC016941 AI311652 BM698406 CB136128 BE795638 AA705401 BE302365 
    BG910161 BU856827 CF128626 CA418778 BQ692014 BX279991 BQ227687 CB143179 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC14 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                          -                 -     -         
    SP3:                                                                          -     -                                                                           
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 24
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for DNAJC14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNAJC14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTATTTAAA
    DNAJC14 Expression
    About this image

    DNAJC14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAJC14 Protein Expression

    UniProtKB/Swiss-Prot: DJC14_HUMAN, Q6Y2X3
    Tissue specificity: Highly expressed in pancreas and selectively expressed in brain, lung, liver, skeletal muscle
    and kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including DNAJC14: 
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:
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    QuantiFast Probe-based Assays in human, mouse, rat DNAJC14
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DNAJC14 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnajc141 , 5 DnaJ (Hsp40) homolog, subfamily C, member 141, 5 86.31(n)1
    85.02(a)1
      10 (77.16 cM)5
    743301  NM_028873.41  NP_083149.31 
     1288056765 
    chicken
    (Gallus gallus)
    Aves LOC4264181 dnaJ homolog subfamily C member 14-like 74.47(n)
    80.85(a)
      426418  XM_004950745.1  XP_004950802.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    52(a)
    1 → many
    GL343198.1(3087248-3103105)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dnajc141 DnaJ (Hsp40) homolog, subfamily C, member 14 58.06(n)
    56.34(a)
      100492720  XM_004911890.1  XP_004911947.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5558241 dnaJ homolog subfamily C member 14-like 66.67(n)
    71.34(a)
      555824  XM_678465.4  XP_683557.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG146506
    --
    19(a)
    1 → many
    3R(263150-267050)
    worm
    (Caenorhabditis elegans)
    Secernentea dnj-56
    Protein DNJ-5, isoform d
    14(a)
    1 → many
    II(6853469-6858298) WBGene00001023
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HLJ16
    Co-chaperone for Hsp40p, anchored in the ER membra...
    17(a)
    1 → many
    XIII(577718-578392) YMR161W


    ENSEMBL Gene Tree for DNAJC14 (if available)
    TreeFam Gene Tree for DNAJC14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNAJC14 gene
    ENSG000002573902  DNAJB122  DNAJC162  DNAJC182  DNAJB142  

    Find genes that share paralogs with DNAJC14           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNAJC14 (see all 156)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1379203001,2
    C--56215565(+) GAACCC/TGGGAG 1 -- ut310--------
    rs1839762331,2
    --56215566(+) AACCCA/GGGAGA 1 -- ut310--------
    rs1996958521,2
    C--56215765(+) ATCAAC/TGTTGG 2 H R mis11Minor allele frequency- T:0.00EU 1323
    rs1131006891,2
    C--56215793(+) CTTCCG/TCCGCT 2 R syn11Minor allele frequency- T:0.50CSA 2
    rs1996334181,2
    C--56215891(+) TCCCAC/TTGGGC 2 N S mis10--------
    rs1398464721,2
    --56216061(+) TCCTAA/GAAAAC 1 -- int10--------
    rs123082771,2
    C,F,H--56216070(+) ACAAGG/TCCCCT 1 -- int118Minor allele frequency- T:0.14NS EA WA NA CSA 2105
    rs1438817181,2
    --56216076(+) CCCCTC/GGGTGT 1 -- int10--------
    rs1882591861,2
    --56216090(+) AAAAAA/GCAGGT 1 -- int10--------
    rs2011165871,2
    C--56216107(+) AAACCA/C/GTATTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for DNAJC14 (56214744 - 56224608 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DNAJC14:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675015CNV Deletion23128226
    nsv832423CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAJC14
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAJC14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606092    OMIM disorders: --

    2 diseases for DNAJC14:    
    About MalaCards
    bipolar disorder    schizophrenia


    Find genes that share disorders with DNAJC14           About GenesLikeMe

    3 Novoseek inferred disease relationships for DNAJC14 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcyon 94.7 1 15364041 (1)
    schizophrenia 54.6 5 15364041 (2), 12622665 (2), 12496348 (1)
    bipolar disorder 35 1 12496348 (1)


    Export disorders for DNAJC14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNAJC14 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with DNAJC14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein. (PubMed id 11331877)1, 2, 3 Bermak J.C.... Zhou Q.-Y. (Nat. Cell Biol. 2001)
    2. Molecular cloning and characterization of a novel human J-domain protein gene (HDJ3) from the fetal brain. (PubMed id 12768437)1, 2, 9 Chen J.... Xie Y. (J. Hum. Genet. 2003)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. (PubMed id 11984006)1, 3 Tchernev V.T.... Kingsmore S.F. (Mol. Med. 2002)
    6. A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling. (PubMed id 12446598)1, 9 Leclerc P.C....Guillemette G. (Endocrinology 2002)
    7. Flavivirus replication complex assembly revealed by DNAJC14 functional mapping. (PubMed id 22915803)1 Yi Z....MacDonald M.R. (J. Virol. 2012)
    8. Dopamine receptor-interacting protein 78 acts as a molecular chaperone for CCR5 chemokine receptor signaling complex organization. (PubMed id 22815758)1 Kuang Y.Q....DuprAc D.J. (PLoS ONE 2012)
    9. Identification and characterization of the host protein DNAJC14 as a broadly active flavivirus replication modulator. (PubMed id 21249176)1 Yi Z....MacDonald M.R. (PLoS Pathog. 2011)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85406 HGNC: 24581 AceView: DNAJC14andCIP29 Ensembl:ENSG00000135392 euGenes: HUgn85406
    ECgene: DNAJC14 H-InvDB: DNAJC14

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DNAJC14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNAJC14 gene:
    Search GeneIP for patents involving DNAJC14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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