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Aliases for DNAJC14 Gene

Aliases for DNAJC14 Gene

  • DnaJ (Hsp40) Homolog, Subfamily C, Member 14 2 3
  • DRIP78 3 4 6
  • HDJ3 3 4 6
  • Dopamine Receptor-Interacting Protein Of 78 KDa 3 4
  • DnaJ Protein Homolog 3 3 4
  • Human DnaJ Protein 3 3 4
  • HDj-3 3 4
  • Dopamine Receptor Interacting Protein 3
  • DnaJ Homolog Subfamily C Member 14 3
  • LYST-Interacting Protein LIP6 3
  • DNAJ 3
  • LIP6 3

External Ids for DNAJC14 Gene

Previous GeneCards Identifiers for DNAJC14 Gene

  • GC12M054439
  • GC12M054440
  • GC12M054501
  • GC12M056214
  • GC12M053253

Summaries for DNAJC14 Gene

GeneCards Summary for DNAJC14 Gene

DNAJC14 (DnaJ (Hsp40) Homolog, Subfamily C, Member 14) is a Protein Coding gene. Diseases associated with DNAJC14 include bipolar disorder and schizophrenia. An important paralog of this gene is DNAJC18.

UniProtKB/Swiss-Prot for DNAJC14 Gene

  • Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface.

Gene Wiki entry for DNAJC14 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC14 Gene

Genomics for DNAJC14 Gene

Regulatory Elements for DNAJC14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DNAJC14 Gene

55,820,960 bp from pter
55,830,824 bp from pter
9,865 bases
Minus strand

Genomic View for DNAJC14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJC14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC14 Gene

Proteins for DNAJC14 Gene

  • Protein details for DNAJC14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily C member 14
    Protein Accession:
    Secondary Accessions:
    • A5YM67
    • Q17RY2
    • Q66K17
    • Q96N59
    • Q96T63

    Protein attributes for DNAJC14 Gene

    702 amino acids
    Molecular mass:
    78569 Da
    Quaternary structure:
    • Interacts with the FxxxFxxxF motif of DRD1 via its C-terminal domain.
    • Sequence=BAB71050.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DNAJC14 Gene

Proteomics data for DNAJC14 Gene at MOPED

Post-translational modifications for DNAJC14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJC14 Gene

No data available for DME Specific Peptides for DNAJC14 Gene

Domains for DNAJC14 Gene

Gene Families for DNAJC14 Gene

  • DNAJ :Heat shock proteins / DNAJ (HSP40)

Protein Domains for DNAJC14 Gene


Suggested Antigen Peptide Sequences for DNAJC14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6Y2X3
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJC14: view

Function for DNAJC14 Gene

Molecular function for DNAJC14 Gene

UniProtKB/Swiss-Prot Function:
Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface.

Animal Model Products

CRISPR Products

miRNA for DNAJC14 Gene

miRTarBase miRNAs that target DNAJC14

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJC14

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DNAJC14 Gene

Localization for DNAJC14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC14 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for DNAJC14 Gene COMPARTMENTS Subcellular localization image for DNAJC14 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 4
cytosol 3
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DNAJC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DNAJC14: view

Pathways for DNAJC14 Gene

SuperPathways for DNAJC14 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for DNAJC14 Gene

Gene Ontology (GO) - Biological Process for DNAJC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with DNAJC14: view

No data available for Pathways by source for DNAJC14 Gene

Compounds for DNAJC14 Gene

(1) Novoseek inferred chemical compound relationships for DNAJC14 Gene

Compound -log(P) Hits PubMed IDs
dopamine 63.9 22
genes like me logo Genes that share compounds with DNAJC14: view

Transcripts for DNAJC14 Gene

Unigene Clusters for DNAJC14 Gene

DnaJ (Hsp40) homolog, subfamily C, member 14:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJC14

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC14 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP2: - - -
SP3: - -

ExUns: 24

Relevant External Links for DNAJC14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJC14 Gene

mRNA expression in normal human tissues for DNAJC14 Gene

Protein differential expression in normal tissues for DNAJC14 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.4), Placenta (21.5), CD8 Tcells (9.3), and Testis (7.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJC14 Gene

SOURCE GeneReport for Unigene cluster for DNAJC14 Gene Hs.709320

mRNA Expression by UniProt/SwissProt for DNAJC14 Gene

Tissue specificity: Highly expressed in pancreas and selectively expressed in brain, lung, liver, skeletal muscle and kidney.
genes like me logo Genes that share expressions with DNAJC14: view

Expression partners for DNAJC14 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DNAJC14 Gene

Orthologs for DNAJC14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNAJC14 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DNAJC14 35
  • 90.53 (n)
  • 90.53 (a)
DNAJC14 36
  • 91 (a)
(Canis familiaris)
Mammalia DNAJC14 35
  • 91.69 (n)
  • 91.17 (a)
-- 36
  • 91 (a)
(Mus musculus)
Mammalia Dnajc14 35
  • 86.31 (n)
  • 85.02 (a)
Dnajc14 16
Dnajc14 36
  • 86 (a)
(Pan troglodytes)
Mammalia DNAJC14 35
  • 99.76 (n)
  • 99.72 (a)
DNAJC14 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Dnajc14 35
  • 86.21 (n)
  • 85.59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
(Gallus gallus)
Aves LOC426418 35
  • 74.47 (n)
  • 80.85 (a)
-- 36
  • 79 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc14 35
  • 58.06 (n)
  • 56.34 (a)
(Danio rerio)
Actinopterygii LOC555824 35
  • 66.67 (n)
  • 71.34 (a)
DNAJC14 36
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14650 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea dnj-5 36
  • 14 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HLJ1 36
  • 17 (a)
Species with no ortholog for DNAJC14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC14 Gene

Gene Tree for DNAJC14 (if available)
Gene Tree for DNAJC14 (if available)

Paralogs for DNAJC14 Gene

Paralogs for DNAJC14 Gene

genes like me logo Genes that share paralogs with DNAJC14: view

Variants for DNAJC14 Gene

Sequence variations from dbSNP and Humsavar for DNAJC14 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1871999 -- 55,826,338(-) agctg(C/G)gatca intron-variant
rs7316533 -- 55,824,541(+) GCTAA(C/T)TGAAC intron-variant
rs7956337 -- 55,825,431(+) CAATC(C/T)GTTAT intron-variant
rs7970102 -- 55,825,732(+) gtaga(A/G)acagg intron-variant
rs10876853 -- 55,824,964(+) cattt(C/T)tacta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC14 Gene

Variant ID Type Subtype PubMed ID
nsv832423 CNV Gain 17160897
esv2675015 CNV Deletion 23128226

Relevant External Links for DNAJC14 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC14 Gene

Disorders for DNAJC14 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for DNAJC14 Gene in MalaCards »

(2) Diseases for DNAJC14 Gene including...

(3) Novoseek inferred disease relationships for DNAJC14 Gene

Disease -log(P) Hits PubMed IDs
calcyon 94.7 1
schizophrenia 54.6 5
bipolar disorder 35 1
genes like me logo Genes that share disorders with DNAJC14: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for DNAJC14 Gene

Publications for DNAJC14 Gene

  1. Molecular cloning and characterization of a novel human J-domain protein gene (HDJ3) from the fetal brain. (PMID: 12768437) Chen J. … Xie Y. (J. Hum. Genet. 2003) 3 4 23
  2. Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein. (PMID: 11331877) Bermak J.C. … Zhou Q.-Y. (Nat. Cell Biol. 2001) 2 3 4
  3. The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. (PMID: 11984006) Tchernev V.T. … Kingsmore S.F. (Mol. Med. 2002) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling. (PMID: 12446598) Leclerc P.C. … Guillemette G. (Endocrinology 2002) 3 23

Products for DNAJC14 Gene

Sources for DNAJC14 Gene

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