DNAJC13 Gene
protein-coding GIFtS: 49
GCID: GC03P132136
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DnaJ (Hsp40) homolog, subfamily C, member 13
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Aliases
for DNAJC13 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DnaJ (Hsp40) Homolog, Subfamily C, Member 131 2 | | RME-82 3 | | RME81 2 3 | | DnaJ Domain-Containing Protein RME-82 | | KIAA06781 3 | | DnaJ Homolog Subfamily C Member 132 | | Required For Receptor-Mediated Endocytosis 82 3 | | |
Export aliases for DNAJC13 gene to outside databasesPrevious GC identifers: GC03P133442 GC03P133665 GC03P129515 |
Summaries
for DNAJC13 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for DNAJC13
|
Genomic Views
for DNAJC13 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DNAJC13 gene promoter:
USF1 AML1a POU3F2 Tal-1beta NF-AT NF-AT4 USF-1 ITF-2 Ik-1 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DNAJC13
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJC13 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q22.1 Ensembl cytogenetic band: 3q22.1 HGNC cytogenetic band: 3q22.1DNAJC13 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P132136: view genomic region
(about GC identifiers)
Start:
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132,136,370 bp from pter |
End:
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132,257,876 bp from pter |
Size:
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121,507 bases |
Orientation:
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plus strand |
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Proteins
for DNAJC13 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DJC13_HUMAN, O75165 (See
protein sequence)Recommended Name: DnaJ homolog subfamily C member 13 Size: 2243 amino acids; 254415 Da
Sequence caution: Sequence=AAH43583.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;Sequence=BAA31653.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAC86133.1;Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC86835.1; Type=Erroneous initiation;Note=Translation N-terminally extended; Sequence=BAC86835.1; Type=Erroneous termination; Positions=1651;Note=Translated as Glu;
Secondary accessions: Q3L0T1 Q6PI82 Q6UJ77 Q6ZSW1 Q6ZUT5 Q86XG3 Q96DC1 Q9BWK9Explore the universe of human proteins at neXtProt for DNAJC13: NX_O75165
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75165
DNAJC13 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056083.3
ENSEMBL proteins: ENSP00000260818 ENSP00000421735 ENSP00000426240
Human Recombinant Protein Products:
DNAJC13 Antibody Products:
Assay Products for DNAJC13: |
Protein
Domains /
Families
for DNAJC13 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DNAJC13 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75165ProtoNet protein and cluster: O75165 UniProtKB/Swiss-Prot: DJC13_HUMAN, O75165Similarity: Contains 1 J domain |
Function
for DNAJC13 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC13 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC13
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DNAJC13 (NM_015268) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DNAJC13 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC13 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC13 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0031072 | heat shock protein binding |
IEA | -- |
DNAJC13 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for DNAJC13:
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Pathways & Interactions
for DNAJC13 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNAJC13
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
5/580 Interacting proteins for DNAJC13 (O751652, 3 ENSP000002608184) via UniProtKB, MINT, STRING, and/or I2D (see all 580)About this table
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Drugs & Compounds
for DNAJC13 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DNAJC13
Search CenterWatch for drugs/clinical trials and news about DNAJC13 / DJC13
|
Transcripts
for DNAJC13 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DNAJC13 gene: NM_015268.3 Unigene Cluster for DNAJC13: DnaJ (Hsp40) homolog, subfamily C, member 13 Hs.12707 [show with all ESTs]Unigene Representative Sequence: BC1512468 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000260818(uc003eor.3) ENST00000486798(uc010htq.2) ENST00000471925(uc003eos.1)
ENST00000464766 ENST00000506813 ENST00000513822 ENST00000463038 ENST00000509279
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC13 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC13
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DNAJC13 (NM_015268) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DNAJC13 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC13 |
Additional cDNA sequence: AB014578.2 AK023168.1 AK098729.1 AK125330.1 AK127112.1 AY369172.1 AY779857.1 BC000164.3 BC009630.1 BC033782.1 BC040638.2 BC043583.1 BC065756.1 BC105580.1 BC151246.1 10 DOTS entries: DT.99935621 DT.446823 DT.95301356 DT.95161750 DT.91713106 DT.92433769 DT.92433750 DT.120841542 DT.95120178 DT.91647528 24/200 AceView cDNA sequences (see all 200): AA862000 BU521411 BQ425707 BM821274 AA778850 BC040638 AA760761 AU124105 AA854088 H39910 AA767028 BM711256 AI459762 CB158078 AA234225 AB014578 F09582 BI870420 N58758 AA507052 BM557429 AA361699 AA745248 BU507688
GeneLoc Exon Structure
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Expression
for DNAJC13 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DNAJC13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTGTAGGGT
About this image
See DNAJC13 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DNAJC13
SOURCE GeneReport for Unigene cluster: Hs.12707
SABiosciences Expression via Pathway-Focused PCR Array including DNAJC13: | Heat Shock Proteins & Chaperones in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNAJC13
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat DNAJC13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAJC13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAJC13 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC13 |
Orthologs
for DNAJC13 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for DNAJC13 gene from 9/27 species (see all 27) About this table
ENSEMBL Gene Tree for DNAJC13 (if available)
TreeFam Gene Tree for DNAJC13 (if available) |
Paralogs
for DNAJC13 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DNAJC13 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DNAJC13 (132136370 - 132257876 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DNAJC13: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNAJC13 |
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Disorders
/ Diseases
for DNAJC13 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DNAJC13 for disorders About GeneDecksing
OMIM gene information: 614334
OMIM disorders: --
3  diseases for DNAJC13: About MalaCardssenior-loken syndrome leber congenital amaurosis nephronophthisis
1 disease from the University of Copenhagen DISEASES database for DNAJC13:Chronic tic disorder Human Genome Epidemiology (HuGE) Navigator: DNAJC13 (1 document)
Export disorders for DNAJC13 gene to outside databases
|
Publications
for DNAJC13 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DNAJC13 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with DNAJC13) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DnaJ-domain protein RME-8 functions in endosomal trafficking. (PubMed id 16179350)1, 2 Girard M.... McPherson P.S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Candidate gene analysis of KIAA0678 encoding a DnaJ-like protein for adolescent nephronophthisis and Senior-Loken syndrome type 3. (PubMed id 12438707)1, 3 Volz A....Omran H. (2002)
- Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (1998)
- Analysis of the MRPL3, DNAJC13 and OFCC1 variants in C hinese Han patients with TS-CTD. (PubMed id 22507240)1 Guo Y....Deng H. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
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External Searches for DNAJC13 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing DNAJC13 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DNAJC13 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing DNAJC13 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DNAJC13 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for DNAJC13 gene:
Search GeneIP for patents involving DNAJC13
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DNAJC13 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNAJC13 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNAJC13 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DNAJC13 | | OriGene 3'-UTR Clone for DNAJC13 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC13 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJC13 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DNAJC13 | | OriGene Custom Protein Services for DNAJC13 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DNAJC13 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNAJC13 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJC13 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNAJC13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAJC13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAJC13 |
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 | | | DNAJC13 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC13 |
|  |  |  | | | | Search ThermoFisher Antibodies for DNAJC13 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC13 |
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