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Aliases for DNAJC12 Gene

Aliases for DNAJC12 Gene

  • DnaJ (Hsp40) Homolog, Subfamily C, Member 12 2 3
  • J Domain-Containing Protein 1 3 4
  • J Domain Protein 1 2 3
  • JDP1 3 4
  • J Domain Containing Protein 1 (JDP1) 3

External Ids for DNAJC12 Gene

Previous GeneCards Identifiers for DNAJC12 Gene

  • GC10M068902
  • GC10M069226
  • GC10M069556
  • GC10M063555

Summaries for DNAJC12 Gene

Entrez Gene Summary for DNAJC12 Gene

  • This gene encodes a member of a subclass of the HSP40/DnaJ protein family. Members of this family of proteins are associated with complex assembly, protein folding, and export. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DNAJC12 Gene

DNAJC12 (DnaJ (Hsp40) Homolog, Subfamily C, Member 12) is a Protein Coding gene. An important paralog of this gene is DNAJC17.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC12 Gene

Genomics for DNAJC12 Gene

Regulatory Elements for DNAJC12 Gene

Genomic Location for DNAJC12 Gene

67,796,665 bp from pter
67,838,191 bp from pter
41,527 bases
Minus strand

Genomic View for DNAJC12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJC12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC12 Gene

Proteins for DNAJC12 Gene

  • Protein details for DNAJC12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily C member 12
    Protein Accession:
    Secondary Accessions:
    • Q5JVQ1
    • Q9UKB2

    Protein attributes for DNAJC12 Gene

    198 amino acids
    Molecular mass:
    23415 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DNAJC12 Gene

    Alternative splice isoforms for DNAJC12 Gene


neXtProt entry for DNAJC12 Gene

Proteomics data for DNAJC12 Gene at MOPED

Post-translational modifications for DNAJC12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJC12 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for DNAJC12

No data available for DME Specific Peptides for DNAJC12 Gene

Domains & Families for DNAJC12 Gene

Gene Families for DNAJC12 Gene

Protein Domains for DNAJC12 Gene


Suggested Antigen Peptide Sequences for DNAJC12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 J domain.
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJC12: view

Function for DNAJC12 Gene

genes like me logo Genes that share phenotypes with DNAJC12: view

Animal Model Products

CRISPR Products

miRNA for DNAJC12 Gene

miRTarBase miRNAs that target DNAJC12

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJC12

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJC12 Gene

Localization for DNAJC12 Gene

Subcellular locations from

Jensen Localization Image for DNAJC12 Gene COMPARTMENTS Subcellular localization image for DNAJC12 gene
Compartment Confidence
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DNAJC12 Gene

Pathways & Interactions for DNAJC12 Gene

SuperPathways for DNAJC12 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Heat Shock Proteins & Chaperones in human,mouse,rat

Interacting Proteins for DNAJC12 Gene

Gene Ontology (GO) - Biological Process for DNAJC12 Gene


No data available for Pathways by source and SIGNOR curated interactions for DNAJC12 Gene

Drugs & Compounds for DNAJC12 Gene

No Compound Related Data Available

Transcripts for DNAJC12 Gene

Unigene Clusters for DNAJC12 Gene

DnaJ (Hsp40) homolog, subfamily C, member 12:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJC12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC12 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6: - - - -

Relevant External Links for DNAJC12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJC12 Gene

mRNA expression in normal human tissues for DNAJC12 Gene

mRNA differential expression in normal tissues according to GTEx for DNAJC12 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.7) and Liver (x4.2).

Protein differential expression in normal tissues from HIPED for DNAJC12 Gene

This gene is overexpressed in Heart (23.9), Liver (23.2), Testis (11.4), and Pancreas (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJC12 Gene

SOURCE GeneReport for Unigene cluster for DNAJC12 Gene Hs.260720

mRNA Expression by UniProt/SwissProt for DNAJC12 Gene

Tissue specificity: Expressed at high levels in brain, heart, and testis, and at reduced levels in kidney and stomach
genes like me logo Genes that share expression patterns with DNAJC12: view

Protein tissue co-expression partners for DNAJC12 Gene

Primer Products

In Situ Assay Products

Orthologs for DNAJC12 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAJC12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DNAJC12 35
  • 89.23 (n)
  • 85.35 (a)
DNAJC12 36
  • 85 (a)
(Canis familiaris)
Mammalia DNAJC12 35
  • 92.93 (n)
  • 93.94 (a)
DNAJC12 36
  • 84 (a)
(Mus musculus)
Mammalia Dnajc12 35
  • 80.13 (n)
  • 77.27 (a)
Dnajc12 16
Dnajc12 36
  • 77 (a)
(Pan troglodytes)
Mammalia DNAJC12 35
  • 99.16 (n)
  • 97.47 (a)
DNAJC12 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Dnajc12 35
  • 80.13 (n)
  • 76.26 (a)
(Monodelphis domestica)
Mammalia DNAJC12 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia DNAJC12 36
  • 57 (a)
(Gallus gallus)
Aves DNAJC12 35
  • 70.92 (n)
  • 63.27 (a)
DNAJC12 36
  • 62 (a)
(Anolis carolinensis)
Reptilia DNAJC12 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493658 35
  • 63.59 (n)
  • 61.41 (a)
(Danio rerio)
Actinopterygii dnajc12 35
  • 64.44 (n)
  • 65.45 (a)
Dr.14456 35
dnajc12 36
  • 54 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.937 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000970 35
  • 50.46 (n)
  • 36.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta jdp 35
  • 48.98 (n)
  • 40.22 (a)
jdp 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea K07F5.16 36
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10333 36
  • 39 (a)
Species with no ortholog for DNAJC12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC12 Gene

Gene Tree for DNAJC12 (if available)
Gene Tree for DNAJC12 (if available)

Paralogs for DNAJC12 Gene

Paralogs for DNAJC12 Gene

(3) SIMAP similar genes for DNAJC12 Gene using alignment to 4 proteins: Pseudogenes for DNAJC12 Gene

genes like me logo Genes that share paralogs with DNAJC12: view

Variants for DNAJC12 Gene

Sequence variations from dbSNP and Humsavar for DNAJC12 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs962608 -- 67,823,448(-) ATAGG(C/T)GTGAG intron-variant
rs1885474 -- 67,806,993(+) CGCAG(G/T)GGCTC intron-variant
rs1985797 -- 67,836,214(-) CCTCC(C/T)CTTCT intron-variant
rs2025161 -- 67,834,626(+) agttc(A/G)aggcc intron-variant
rs2146055 -- 67,801,003(+) TTATT(C/T)TAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC12 Gene

Variant ID Type Subtype PubMed ID
esv1000438 CNV Insertion 20482838
esv1143947 CNV Insertion 17803354

Variation tolerance for DNAJC12 Gene

Residual Variation Intolerance Score: 57.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.69; 46.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC12 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC12 Gene

Disorders for DNAJC12 Gene

Relevant External Links for DNAJC12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DNAJC12: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC12 Gene

Publications for DNAJC12 Gene

  1. JDP1 (DNAJC12/Hsp40) expression in breast cancer and its association with estrogen receptor status. (PMID: 16391838) De Bessa S.A. … Nagai M.A. (Int. J. Mol. Med. 2006) 23 67
  2. Characterization of JDP genes, an evolutionarily conserved J domain- only protein family, from human and moths. (PMID: 10760603) Lee J. … Chung J.H. (Biochim. Biophys. Acta 2000) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Overexpression of DNAJC12 predicts poor response to neoadjuvant concurrent chemoradiotherapy in patients with rectal cancer. (PMID: 25805104) He H.L. … Li C.F. (Exp. Mol. Pathol. 2015) 67
  5. The co-chaperone DNAJC12 binds to Hsc70 and is upregulated by endoplasmic reticulum stress. (PMID: 24122553) Choi J. … Labrie C. (Cell Stress Chaperones 2014) 67

Products for DNAJC12 Gene

Sources for DNAJC12 Gene

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