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Aliases for DNAJC12 Gene

Aliases for DNAJC12 Gene

  • DnaJ (Hsp40) Homolog, Subfamily C, Member 12 2 3
  • JDP1 3 4 6
  • J Domain-Containing Protein 1 3 4
  • J Domain Protein 1 2 3
  • J Domain Containing Protein 1 (JDP1) 3
  • DnaJ Homolog Subfamily C Member 12 3

External Ids for DNAJC12 Gene

Previous GeneCards Identifiers for DNAJC12 Gene

  • GC10M068902
  • GC10M069226
  • GC10M069556
  • GC10M063555

Summaries for DNAJC12 Gene

Entrez Gene Summary for DNAJC12 Gene

  • This gene encodes a member of a subclass of the HSP40/DnaJ protein family. Members of this family of proteins are associated with complex assembly, protein folding, and export. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DNAJC12 Gene

DNAJC12 (DnaJ (Hsp40) Homolog, Subfamily C, Member 12) is a Protein Coding gene. Diseases associated with DNAJC12 include polycystic liver disease. An important paralog of this gene is DNAJC17.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC12 Gene

Genomics for DNAJC12 Gene

Regulatory Elements for DNAJC12 Gene

Genomic Location for DNAJC12 Gene

Start:
67,796,665 bp from pter
End:
67,838,179 bp from pter
Size:
41,515 bases
Orientation:
Minus strand

Genomic View for DNAJC12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJC12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC12 Gene

Proteins for DNAJC12 Gene

  • Protein details for DNAJC12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKB3-DJC12_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 12
    Protein Accession:
    Q9UKB3
    Secondary Accessions:
    • Q5JVQ1
    • Q9UKB2

    Protein attributes for DNAJC12 Gene

    Size:
    198 amino acids
    Molecular mass:
    23415 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DNAJC12 Gene

    Alternative splice isoforms for DNAJC12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJC12 Gene

Proteomics data for DNAJC12 Gene at MOPED

Post-translational modifications for DNAJC12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJC12 Gene

No data available for DME Specific Peptides for DNAJC12 Gene

Domains for DNAJC12 Gene

Gene Families for DNAJC12 Gene

HGNC:
  • DNAJ :Heat shock proteins / DNAJ (HSP40)

Protein Domains for DNAJC12 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DNAJC12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKB3

UniProtKB/Swiss-Prot:

DJC12_HUMAN :
  • Q9UKB3
Domain:
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJC12: view

Function for DNAJC12 Gene

Phenotypes for DNAJC12 Gene

GenomeRNAi human phenotypes for DNAJC12:
genes like me logo Genes that share phenotypes with DNAJC12: view

Animal Model Products

CRISPR Products

miRNA for DNAJC12 Gene

miRTarBase miRNAs that target DNAJC12

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJC12

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for DNAJC12 Gene

Localization for DNAJC12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJC12 Gene COMPARTMENTS Subcellular localization image for DNAJC12 gene
Compartment Confidence
nucleus 3
cytosol 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DNAJC12 Gene

Pathways for DNAJC12 Gene

SuperPathways for DNAJC12 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Heat Shock Proteins & Chaperones in human,mouse,rat

Interacting Proteins for DNAJC12 Gene

Gene Ontology (GO) - Biological Process for DNAJC12 Gene

None

No data available for Pathways by source for DNAJC12 Gene

Transcripts for DNAJC12 Gene

Unigene Clusters for DNAJC12 Gene

DnaJ (Hsp40) homolog, subfamily C, member 12:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJC12

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC12 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6: - - - -

Relevant External Links for DNAJC12 Gene

GeneLoc Exon Structure for
DNAJC12
ECgene alternative splicing isoforms for
DNAJC12

Expression for DNAJC12 Gene

mRNA expression in normal human tissues for DNAJC12 Gene

mRNA differential expression in normal tissues according to GTEx for DNAJC12 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (4.7) and Liver (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJC12 Gene

SOURCE GeneReport for Unigene cluster for DNAJC12 Gene Hs.260720

mRNA Expression by UniProt/SwissProt for DNAJC12 Gene

Q9UKB3-DJC12_HUMAN
Tissue specificity: Expressed at high levels in brain, heart, and testis, and at reduced levels in kidney and stomach
genes like me logo Genes that share expressions with DNAJC12: view

In Situ Assay Products

Orthologs for DNAJC12 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAJC12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC12 35
  • 99.16 (n)
  • 97.47 (a)
DNAJC12 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAJC12 35
  • 89.23 (n)
  • 85.35 (a)
DNAJC12 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJC12 35
  • 92.93 (n)
  • 93.94 (a)
DNAJC12 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajc12 35
  • 80.13 (n)
  • 77.27 (a)
Dnajc12 16
Dnajc12 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNAJC12 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC12 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajc12 35
  • 80.13 (n)
  • 76.26 (a)
chicken
(Gallus gallus)
Aves DNAJC12 35
  • 70.92 (n)
  • 63.27 (a)
DNAJC12 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJC12 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493658 35
  • 63.59 (n)
  • 61.41 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.937 35
zebrafish
(Danio rerio)
Actinopterygii dnajc12 35
  • 64.44 (n)
  • 65.45 (a)
dnajc12 36
  • 54 (a)
OneToOne
Dr.14456 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000970 35
  • 50.46 (n)
  • 36.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta jdp 35
  • 48.98 (n)
  • 40.22 (a)
jdp 36
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea K07F5.16 36
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10333 36
  • 39 (a)
OneToOne
Species with no ortholog for DNAJC12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC12 Gene

ENSEMBL:
Gene Tree for DNAJC12 (if available)
TreeFam:
Gene Tree for DNAJC12 (if available)

Paralogs for DNAJC12 Gene

Paralogs for DNAJC12 Gene

Selected SIMAP similar genes for DNAJC12 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for DNAJC12 Gene

genes like me logo Genes that share paralogs with DNAJC12: view

Variants for DNAJC12 Gene

Sequence variations from dbSNP and Humsavar for DNAJC12 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs962608 -- 67,823,448(-) ATAGG(C/T)GTGAG intron-variant
rs1885474 -- 67,806,993(+) CGCAG(G/T)GGCTC intron-variant
rs1985797 -- 67,836,214(-) CCTCC(C/T)CTTCT intron-variant
rs2025161 -- 67,834,626(+) agttc(A/G)aggcc intron-variant
rs2146055 -- 67,801,003(+) TTATT(C/T)TAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC12 Gene

Variant ID Type Subtype PubMed ID
esv1000438 CNV Insertion 20482838
esv1143947 CNV Insertion 17803354

Relevant External Links for DNAJC12 Gene

HapMap Linkage Disequilibrium report
DNAJC12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC12 Gene

Disorders for DNAJC12 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for DNAJC12 Gene including...

Search for DNAJC12 Gene in MalaCards »

(1) University of Copenhagen DISEASES for DNAJC12 Gene

Relevant External Links for DNAJC12

Genetic Association Database (GAD)
DNAJC12
Human Genome Epidemiology (HuGE) Navigator
DNAJC12
genes like me logo Genes that share disorders with DNAJC12: view

No data available for UniProtKB/Swiss-Prot for DNAJC12 Gene

Publications for DNAJC12 Gene

  1. Characterization of JDP genes, an evolutionarily conserved J domain- only protein family, from human and moths. (PMID: 10760603) Lee J. … Chung J.H. (Biochim. Biophys. Acta 2000) 2 3 4
  2. JDP1 (DNAJC12/Hsp40) expression in breast cancer and its association with estrogen receptor status. (PMID: 16391838) De Bessa S.A. … Nagai M.A. (Int. J. Mol. Med. 2006) 3 23
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48

Products for DNAJC12 Gene

Sources for DNAJC12 Gene

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