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Aliases for DNAJC11 Gene

Aliases for DNAJC11 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C11 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 11 2 3
  • Novel DnaJ Domain-Containing Protein 3
  • DnaJ Homolog Subfamily C Member 11 3
  • DJ126A5.1 3

External Ids for DNAJC11 Gene

Previous GeneCards Identifiers for DNAJC11 Gene

  • GC01M006404
  • GC01M006628
  • GC01M005841
  • GC01M006694

Summaries for DNAJC11 Gene

GeneCards Summary for DNAJC11 Gene

DNAJC11 (DnaJ Heat Shock Protein Family (Hsp40) Member C11) is a Protein Coding gene.

Gene Wiki entry for DNAJC11 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC11 Gene

Genomics for DNAJC11 Gene

Regulatory Elements for DNAJC11 Gene

Enhancers for DNAJC11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F006723 0.8 Ensembl ENCODE 11.1 -22.6 -22556 1.9 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 THAP3 PHF13 DNAJC11 CAMTA1 ENSG00000237436 LINC01672 GC01P006718
GH01F006649 0.3 FANTOM5 11.1 +52.8 52829 0.1 THAP3 DNAJC11 KLHL21 PHF13 GC01M006638
GH01F006815 0.4 Ensembl 10.6 -114.3 -114277 1.2 ESRRA CAMTA1 ENSG00000237436 DNAJC11 RPL37P9
GH01F006805 0.6 Ensembl 10.4 -104.0 -103977 1.8 PKNOX1 MTA2 JUN FEZF1 EBF1 ZEB2 TBX21 RFX5 ZNF585B IKZF1 ENSG00000237436 CAMTA1 DNAJC11 ENSG00000237365 RPL37P9
GH01F006806 1.2 Ensembl ENCODE 10.4 -105.9 -105853 1.7 KLF1 ZNF133 MAFG FEZF1 TEAD3 YY1 ZNF316 GLIS1 HNF4G ZNF24 CAMTA1 ENSG00000237436 DNAJC11 ENSG00000237365 RPL37P9
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DNAJC11 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJC11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001517022 424 1800 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 KLF13

Genomic Location for DNAJC11 Gene

6,634,168 bp from pter
6,701,924 bp from pter
67,757 bases
Minus strand

Genomic View for DNAJC11 Gene

Genes around DNAJC11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC11 Gene

Proteins for DNAJC11 Gene

  • Protein details for DNAJC11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily C member 11
    Protein Accession:
    Secondary Accessions:
    • Q4VWF5
    • Q5VZN0
    • Q6PK20
    • Q6PK70
    • Q8NDM2
    • Q96CL7

    Protein attributes for DNAJC11 Gene

    559 amino acids
    Molecular mass:
    63278 Da
    Quaternary structure:
    • Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9.
    • Sequence=AAH08772.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAJC11 Gene


neXtProt entry for DNAJC11 Gene

Post-translational modifications for DNAJC11 Gene

  • Ubiquitination at Lys 83, Lys 264, and Lys 409
  • Modification sites at PhosphoSitePlus

Other Protein References for DNAJC11 Gene

No data available for DME Specific Peptides for DNAJC11 Gene

Domains & Families for DNAJC11 Gene

Gene Families for DNAJC11 Gene

Protein Domains for DNAJC11 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 J domain.
  • Belongs to the DNAJC11 family.
  • Contains 1 J domain.
  • Belongs to the DNAJC11 family.
genes like me logo Genes that share domains with DNAJC11: view

Function for DNAJC11 Gene

Gene Ontology (GO) - Molecular Function for DNAJC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17500595
genes like me logo Genes that share ontologies with DNAJC11: view
genes like me logo Genes that share phenotypes with DNAJC11: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJC11 Gene

Localization for DNAJC11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC11 Gene


Subcellular locations from

Jensen Localization Image for DNAJC11 Gene COMPARTMENTS Subcellular localization image for DNAJC11 gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for DNAJC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 25997101
GO:0005743 mitochondrial inner membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DNAJC11: view

Pathways & Interactions for DNAJC11 Gene

SuperPathways for DNAJC11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJC11 Gene


No data available for Pathways by source and SIGNOR curated interactions for DNAJC11 Gene

Transcripts for DNAJC11 Gene

Unigene Clusters for DNAJC11 Gene

DnaJ (Hsp40) homolog, subfamily C, member 11:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC11 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: -
SP2: -
SP3: -
SP5: -

Relevant External Links for DNAJC11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJC11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DNAJC11 Gene

Protein differential expression in normal tissues from HIPED for DNAJC11 Gene

This gene is overexpressed in Nasal epithelium (28.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNAJC11 Gene

Protein tissue co-expression partners for DNAJC11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJC11 Gene:


SOURCE GeneReport for Unigene cluster for DNAJC11 Gene:

genes like me logo Genes that share expression patterns with DNAJC11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DNAJC11 Gene

Orthologs for DNAJC11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJC11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DNAJC11 34 35
  • 98.41 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 96 (a)
-- 35
  • 90 (a)
(Monodelphis domestica)
Mammalia DNAJC11 35
  • 95 (a)
(Canis familiaris)
Mammalia DNAJC11 34 35
  • 90.76 (n)
(Mus musculus)
Mammalia Dnajc11 34 16 35
  • 89.03 (n)
(Bos Taurus)
Mammalia DNAJC11 34 35
  • 88.67 (n)
(Rattus norvegicus)
Mammalia Dnajc11 34
  • 88.13 (n)
(Gallus gallus)
Aves DNAJC11 34 35
  • 82.53 (n)
(Anolis carolinensis)
Reptilia DNAJC11 35
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc11 34
  • 78.65 (n)
(Danio rerio)
Actinopterygii DNAJC11 (2 of 2) 35
  • 78 (a)
dnajc11 34 35
  • 74.91 (n)
Dr.9382 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2822 34
fruit fly
(Drosophila melanogaster)
Insecta CG8531 34 35
  • 52.29 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010432 34
  • 51.98 (n)
(Caenorhabditis elegans)
Secernentea dnj-9 34 35
  • 41.68 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCJ1 35
  • 24 (a)
XDJ1 35
  • 19 (a)
APJ1 35
  • 16 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons OWL1 34
  • 44.77 (n)
(Oryza sativa)
Liliopsida Os10g0507800 34
  • 44.47 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9399 35
  • 43 (a)
Species where no ortholog for DNAJC11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC11 Gene

Gene Tree for DNAJC11 (if available)
Gene Tree for DNAJC11 (if available)

Paralogs for DNAJC11 Gene

(3) SIMAP similar genes for DNAJC11 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with DNAJC11: view

No data available for Paralogs for DNAJC11 Gene

Variants for DNAJC11 Gene

Sequence variations from dbSNP and Humsavar for DNAJC11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1043681 -- 6,635,063(-) CTCAA(A/G)TCATT utr-variant-3-prime
rs1043683 -- 6,634,920(-) TCCAC(C/T)GCCTG utr-variant-3-prime
rs1043703 -- 6,634,453(-) GGCCT(A/C)CCTCC downstream-variant-500B, utr-variant-3-prime
rs1043706 -- 6,634,434(-) GGTAT(C/T)TGAGT downstream-variant-500B, utr-variant-3-prime
rs10523 -- 6,635,184(-) TCCTC(C/T)TGCTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DNAJC11 Gene

Variant ID Type Subtype PubMed ID
esv2237641 CNV deletion 18987734
esv2640779 CNV deletion 19546169
esv3585109 CNV loss 21293372
nsv1004598 CNV gain 25217958
nsv1130944 CNV deletion 24896259
nsv1137722 CNV deletion 24896259
nsv1298 CNV insertion 18451855
nsv437199 CNV loss 16327808
nsv525013 CNV loss 19592680
nsv945756 CNV duplication 23825009

Variation tolerance for DNAJC11 Gene

Residual Variation Intolerance Score: 13.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.21; 80.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC11 Gene

Disorders for DNAJC11 Gene

Relevant External Links for DNAJC11

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DNAJC11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC11 Gene

Publications for DNAJC11 Gene

  1. Identification and characterization of FLJ10737 and CAMTA1 genes on the commonly deleted region of neuroblastoma at human chromosome 1p36.31-p36.23. (PMID: 12964007) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 22 64
  2. QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. (PMID: 25997101) Guarani V. … Harper J.W. (Elife 2015) 3 4 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted region at 1p36 in neuroblastoma. (PMID: 17222547) Henrich K.-O. … Westermann F. (Eur. J. Cancer 2007) 3 22 64
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64

Products for DNAJC11 Gene

Sources for DNAJC11 Gene

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