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DNAJC1 Gene

protein-coding   GIFtS: 57
GCID: GC10M022085

DnaJ (Hsp40) Homolog, Subfamily C, Member 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DnaJ (Hsp40) Homolog, Subfamily C, Member 11 2     ERdj12
HTJ12 3 5     MTJ12
DnaJ Protein Homolog MTJ12 3     DnaJ Homolog Subfamily C Member 12
DNAJL12     DnaJ-Like Protein2

External Ids:    HGNC: 200901   Entrez Gene: 642152   Ensembl: ENSG000001367707   OMIM: 6112075   UniProtKB: Q96KC83   

Export aliases for DNAJC1 gene to outside databases

Previous GC identifers: GC10M021762 GC10M022195 GC10M022049


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DNAJC1 Gene:
DNAJC1 (DnaJ (Hsp40) homolog, subfamily C, member 1) is a protein-coding gene. GO annotations related to this gene include chromatin binding and ATPase activator activity. An important paralog of this gene is DNAJC2.

UniProtKB/Swiss-Prot: DNJC1_HUMAN, Q96KC8
Function: May modulate protein synthesis (By similarity)

Gene Wiki entry for DNAJC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_008705.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAJC1 gene promoter:
         Nkx3-1   Nkx3-1 v4   STAT1   AML1a   STAT1beta   Nkx3-1 v1   GATA-2   STAT1alpha   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJC1 promoter sequence
   Search Chromatin IP Primers for DNAJC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAJC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.31   Ensembl cytogenetic band:  10p12.31   HGNC cytogenetic band: 10p11.23

DNAJC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJC1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M022085:  view genomic region     (about GC identifiers)

Start:
22,045,466 bp from pter      End:
22,292,698 bp from pter
Size:
247,233 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DNJC1_HUMAN, Q96KC8 (See protein sequence)
Recommended Name: DnaJ homolog subfamily C member 1 precursor  
Size: 554 amino acids; 63883 Da
Subunit: Interacts (via J domain) with HSPA5. Interacts (via cytosolic domain) with ribosomes (By similarity).
Interacts (via SANT 2 domain) with SERPINA3; the interaction delays the formation of the covalent inhibitory
complex SERPINA3-chymotrypsin, but does not alter the catalytic activity of SERPINA3. Interacts (via SANT 2
domain) with ITIH4 (via C-terminus); the interaction protects ITIH4 against in vitro cleavage by kallikrein
2 PDB 3D structures from and Proteopedia for DNAJC1:
2CQQ (3D)        2CQR (3D)    
Secondary accessions: B0YIZ8 Q5VX89 Q9H6B8

Explore the universe of human proteins at neXtProt for DNAJC1: NX_Q96KC8

Explore proteomics data for DNAJC1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DNAJC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071760.2  
    ENSEMBL proteins: 
     ENSP00000366179   ENSP00000431248   ENSP00000398185   ENSP00000366145  

    DNAJC1 Human Recombinant Protein Products:

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    Novus Biologicals DNAJC1 Protein
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    Cloud-Clone Corp. Proteins for DNAJC1

     
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    antibodies-online proteins for DNAJC1 (4 products) 

     
    antibodies-online peptides for DNAJC1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    5 InterPro protein domains:
     IPR017884 SANT_dom
     IPR001005 SANT/Myb
     IPR001623 DnaJ_domain
     IPR018253 DnaJ_domain_CS
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q96KC8

    ProtoNet protein and cluster: Q96KC8

    UniProtKB/Swiss-Prot: DNJC1_HUMAN, Q96KC8
    Similarity: Contains 1 J domain
    Similarity: Contains 2 SANT domains


    Find genes that share domains with DNAJC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DNJC1_HUMAN, Q96KC8
    Function: May modulate protein synthesis (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001671ATPase activator activity TAS14668352
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding IPI14668352
    GO:0051087chaperone binding IEA--
         
    Find genes that share ontologies with DNAJC1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DNAJC1:
     Increased S DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DNAJC1

    miRNA
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    miRTarBase miRNAs that target DNAJC1:
    hsa-let-7b-5p (MIRT032341), hsa-mir-16-5p (MIRT031667), hsa-mir-124-3p (MIRT002721)

    Block miRNA regulation of human, mouse, rat DNAJC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAJC1 (see all 14):
    hsa-miR-3910 hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidDNAJC1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DNAJC1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: DNAJC1 (NM_015268)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNAJC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJC1

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    Browse ESI BIO Cell Lines and PureStem Progenitors for DNAJC1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DNJC1_HUMAN, Q96KC8: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Nucleus
    membrane; Single-pass type I membrane protein. Microsome membrane; Single-pass type I membrane protein (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus5
    plasma membrane2
    cytosol1
    golgi apparatus1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ISS--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0031965nuclear membrane IEA--

    Find genes that share ontologies with DNAJC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DNAJC1 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum


    Find genes that share SuperPaths with DNAJC1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for DNAJC1):
        Protein processing in endoplasmic reticulum

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJC1: 
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DNAJC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNAJC1 (Q96KC81, 2, 3 ENSP000003661794) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABHD16AO958702, 3, ENSP000003792824MINT-62604 MINT-62778 MINT-62702 I2D: score=5 STRING: ENSP00000379282
    ENSG00000236063O958702, 3, ENSP000004069654MINT-62604 MINT-62778 MINT-62702 I2D: score=5 STRING: ENSP00000406965
    ENSG00000206403O958702, 3MINT-62604 MINT-62778 MINT-62702 I2D: score=5 
    ENSG00000224552O958702, 3MINT-62604 MINT-62778 MINT-62702 I2D: score=5 
    ENSG00000230475O958702, 3MINT-62604 MINT-62778 MINT-62702 I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006417regulation of translation IEA--
    GO:0006457protein folding IEA--
    GO:0032781positive regulation of ATPase activity TAS14668352
    GO:0045861negative regulation of proteolysis TAS14668352
    GO:0050708regulation of protein secretion IDA14668352

    Find genes that share ontologies with DNAJC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNAJC1 (DNJC1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DNAJC1 gene: 
    NM_022365.3  

    Unigene Cluster for DNAJC1:

    DnaJ (Hsp40) homolog, subfamily C, member 1
    Hs.499000  [show with all ESTs]
    Unigene Representative Sequence: BC110894
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376980(uc001irc.3 uc021pnz.1) ENST00000483085 ENST00000476103
    ENST00000447548 ENST00000376946
    miRNA
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    Block miRNA regulation of human, mouse, rat DNAJC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNAJC1 (see all 14):
    hsa-miR-3910 hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidDNAJC1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DNAJC1
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    Primer
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    OriGene qPCR primer pairs and template standards for DNAJC1
    OriGene qSTAR qPCR primer pairs in human, mouse for DNAJC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNAJC1
      QuantiTect SYBR Green Assays in human, mouse, rat DNAJC1
      QuantiFast Probe-based Assays in human, mouse, rat DNAJC1

    Additional mRNA sequence: 

    AF427142.1 AK026062.1 AK027263.1 AK308369.1 AY225122.1 BC014436.1 BC030955.1 BC110894.1 
    BC139752.1 

    8 DOTS entries:

    DT.448659  DT.100781001  DT.117297  DT.121246321  DT.100658593  DT.100757522  DT.121246365  DT.92426562 

    Selected AceView cDNA sequences (see all 196):

    BM971488 AI520955 BX327324 BM729271 BM712350 BM848134 AK026062 CB119718 
    BF591419 NM_022365 CA312696 BQ898994 BU619694 BM803702 BG655729 CK430491 
    BC014436 BQ272198 AI376895 BM682183 BQ016831 AA029891 AA682397 AI078447 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
    SP1:                                                              -                     
    SP2:              -                                                                     
    SP3:                                                                                    


    ECgene alternative splicing isoforms for DNAJC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNAJC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCTTAGTA
    DNAJC1 Expression
    About this image


    DNAJC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Neurons
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Thyroid (Endocrine System)
    DNAJC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAJC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.499000
        Pathway & Disease-focused RT2 Profiler PCR Arrays including DNAJC1: 
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat DNAJC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DNAJC1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnajc11 , 5 DnaJ (Hsp40) homolog, subfamily C, member 11, 5 87.96(n)1
    87.77(a)1
      2 (12.89 cM)5
    134181  NM_007869.31  NP_031895.11 
     181956545 
    chicken
    (Gallus gallus)
    Aves DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 1 77.59(n)
    77.45(a)
      420508  XM_418609.4  XP_418609.4 
    lizard
    (Anolis carolinensis)
    Reptilia DNAJC16
    DnaJ (Hsp40) homolog, subfamily C, member 1
    68(a)
    1 ↔ 1
    6(16471164-16561492)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.150362 Xenopus laevis transcribed sequence with weak similarity more 78.9(n)    BJ031300.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.75152 Transcribed sequence with weak similarity to protein more 75.78(n)    AL913097.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG75566
    --
    31(a)
    1 ↔ 1
    X(19071030-19073988)
    worm
    (Caenorhabditis elegans)
    Secernentea F54F2.91 F54F2.9 47.81(n)
    37.79(a)
      176241  NM_066548.4  NP_498949.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ZUO16
    Ribosome-associated chaperone, functions in riboso...
    13(a)
    1 → many
    VII(1061852-1063153) YGR285C


    ENSEMBL Gene Tree for DNAJC1 (if available)
    TreeFam Gene Tree for DNAJC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNAJC1 gene
    DNAJC22  
    12 SIMAP similar genes for DNAJC1 using alignment to 4 protein entries:     DNJC1_HUMAN (see all proteins):
    DNAJB4    DNAJC10    DNAJB5    DNAJC16    DNAJB12    DNAJB6
    DNAJA4    DNAJC18    DNAJB2    DNAJA3    DNAJC5B    DNAJC17

    Find genes that share paralogs with DNAJC1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for DNAJC1
    PGOHUM00000239854


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNAJC1 (see all 4089)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs788657941,2
    --22045007(+) GAAAAC/TGGTCC 1 -- int10--------
    rs1877265851,2
    --22045011(+) ACGGTC/TCTGCA 1 -- int10--------
    rs64821911,2
    C,F,A,H--22045097(+) CCTCCG/TTCACC 1 -- int132Minor allele frequency- T:0.34NA NS EA WA CSA 3346
    rs1424892851,2
    --22045196(+) TCTTCC/TTCCCC 1 -- int10--------
    rs1509623751,2
    --22045241(+) GACACA/GAACTG 1 -- int10--------
    rs1395025301,2
    --22045398(+) GTGATA/GAGAAA 1 -- int10--------
    rs1923902541,2
    --22045439(+) TTTCCC/TCCAGC 1 -- int10--------
    rs1998776791,2
    C--22045497(+) TTTTT-/TACTAA 1 -- ut310--------
    rs1838844501,2
    C--22045560(+) GCATAA/CGATTT 1 -- ut310--------
    rs2008218561,2
    --22045580(+) TCATTC/TTGGAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DNAJC1 (22045466 - 22292698 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for DNAJC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2511732CNV Deletion19546169
    esv2669848CNV Deletion23128226
    esv2665064CNV Deletion23128226
    nsv507545CNV Insertion20534489
    esv273070CNV Insertion20981092
    nsv894948CNV Loss21882294
    nsv894947CNV Loss21882294
    nsv894949CNV Loss21882294
    nsv831808CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611207    OMIM disorders: --


    Find genes that share disorders with DNAJC1           About GenesLikeMe

    Genetic Association Database (GAD): DNAJC1
    Human Genome Epidemiology (HuGE) Navigator: DNAJC1 (1 document)

    Export disorders for DNAJC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNAJC1 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with DNAJC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    2. The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity. (PubMed id 14668352)1, 2 Kroczynska B....Blond S.Y. (J. Biol. Chem. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    6. BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4. (PubMed id 16271702)1, 9 Kroczynska B....Blond S.Y. (Biochem. Biophys. Res. Commun. 2005)
    7. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (PubMed id 23535729)1 Michailidou K....Easton D.F. (Nat. Genet. 2013)
    8. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PubMed id 23535730)1 Pharoah P.D....Sellers T.A. (Nat. Genet. 2013)
    9. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PubMed id 22412018)1 Roux K.J.... Burke B. (J. Cell Biol. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64215 HGNC: 20090 AceView: DNAJC1 Ensembl:ENSG00000136770 euGenes: HUgn64215
    ECgene: DNAJC1 Kegg: 64215 H-InvDB: DNAJC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DNAJC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNAJC1 gene:
    Search GeneIP for patents involving DNAJC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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