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Aliases for DNAJC1 Gene

Aliases for DNAJC1 Gene

  • DnaJ (Hsp40) Homolog, Subfamily C, Member 1 2 3
  • HTJ1 3 4 6
  • DnaJ Protein Homolog MTJ1 3 4
  • DnaJ Homolog Subfamily C Member 1 3
  • DnaJ-Like Protein 3
  • DNAJL1 3
  • ERdj1 3
  • MTJ1 3

External Ids for DNAJC1 Gene

Previous GeneCards Identifiers for DNAJC1 Gene

  • GC10M022195
  • GC10M022049
  • GC10M022085

Summaries for DNAJC1 Gene

GeneCards Summary for DNAJC1 Gene

DNAJC1 (DnaJ (Hsp40) Homolog, Subfamily C, Member 1) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum. GO annotations related to this gene include chromatin binding and ATPase activator activity. An important paralog of this gene is DNAJC2.

UniProtKB/Swiss-Prot for DNAJC1 Gene

  • May modulate protein synthesis.

Gene Wiki entry for DNAJC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC1 Gene

Genomics for DNAJC1 Gene

Regulatory Elements for DNAJC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DNAJC1 Gene

Start:
21,756,537 bp from pter
End:
22,003,769 bp from pter
Size:
247,233 bases
Orientation:
Minus strand

Genomic View for DNAJC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC1 Gene

Proteins for DNAJC1 Gene

  • Protein details for DNAJC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KC8-DNJC1_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 1
    Protein Accession:
    Q96KC8
    Secondary Accessions:
    • B0YIZ8
    • Q5VX89
    • Q9H6B8

    Protein attributes for DNAJC1 Gene

    Size:
    554 amino acids
    Molecular mass:
    63883 Da
    Quaternary structure:
    • Interacts (via J domain) with HSPA5. Interacts (via cytosolic domain) with ribosomes (By similarity). Interacts (via SANT 2 domain) with SERPINA3; the interaction delays the formation of the covalent inhibitory complex SERPINA3-chymotrypsin, but does not alter the catalytic activity of SERPINA3. Interacts (via SANT 2 domain) with ITIH4 (via C-terminus); the interaction protects ITIH4 against in vitro cleavage by kallikrein.

    Three dimensional structures from OCA and Proteopedia for DNAJC1 Gene

neXtProt entry for DNAJC1 Gene

Proteomics data for DNAJC1 Gene at MOPED

Post-translational modifications for DNAJC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DNAJC1 Gene

Domains for DNAJC1 Gene

Gene Families for DNAJC1 Gene

HGNC:
  • DNAJ :Heat shock proteins / DNAJ (HSP40)

Protein Domains for DNAJC1 Gene

Suggested Antigen Peptide Sequences for DNAJC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96KC8

UniProtKB/Swiss-Prot:

DNJC1_HUMAN :
  • Q96KC8
Domain:
  • Contains 1 J domain.
  • Contains 2 SANT domains.
genes like me logo Genes that share domains with DNAJC1: view

Function for DNAJC1 Gene

Molecular function for DNAJC1 Gene

UniProtKB/Swiss-Prot Function:
May modulate protein synthesis.

Gene Ontology (GO) - Molecular Function for DNAJC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity TAS 14668352
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 14668352
GO:0051087 chaperone binding IEA --
genes like me logo Genes that share ontologies with DNAJC1: view

Phenotypes for DNAJC1 Gene

GenomeRNAi human phenotypes for DNAJC1:
genes like me logo Genes that share phenotypes with DNAJC1: view

Animal Model Products

miRNA for DNAJC1 Gene

miRTarBase miRNAs that target DNAJC1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DNAJC1 Gene

Localization for DNAJC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC1 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Microsome membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJC1 Gene COMPARTMENTS Subcellular localization image for DNAJC1 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
plasma membrane 2
cytosol 1
golgi apparatus 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DNAJC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DNAJC1: view

Pathways for DNAJC1 Gene

genes like me logo Genes that share pathways with DNAJC1: view

Pathways by source for DNAJC1 Gene

1 KEGG pathway for DNAJC1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DNAJC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0006457 protein folding IEA --
GO:0032781 positive regulation of ATPase activity TAS 14668352
GO:0045861 negative regulation of proteolysis TAS 14668352
GO:0050708 regulation of protein secretion IDA 14668352
genes like me logo Genes that share ontologies with DNAJC1: view

Transcripts for DNAJC1 Gene

Unigene Clusters for DNAJC1 Gene

DnaJ (Hsp40) homolog, subfamily C, member 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJC1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: -
SP2: -
SP3:

Relevant External Links for DNAJC1 Gene

GeneLoc Exon Structure for
DNAJC1
ECgene alternative splicing isoforms for
DNAJC1

Expression for DNAJC1 Gene

mRNA expression in normal human tissues for DNAJC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for DNAJC1 Gene

This gene is overexpressed in Pancreas (18.8), Adrenal (7.5), and Peripheral blood mononuclear cells (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJC1 Gene

SOURCE GeneReport for Unigene cluster for DNAJC1 Gene Hs.499000

genes like me logo Genes that share expressions with DNAJC1: view

Expression partners for DNAJC1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DNAJC1 Gene

Orthologs for DNAJC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNAJC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNAJC1 35
  • 87.83 (n)
  • 88.12 (a)
DNAJC1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJC1 35
  • 89.32 (n)
  • 88.93 (a)
DNAJC1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajc1 35
  • 87.96 (n)
  • 87.77 (a)
Dnajc1 16
Dnajc1 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DNAJC1 35
  • 99.46 (n)
  • 99.46 (a)
DNAJC1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100360412 35
  • 86.47 (n)
  • 87.57 (a)
oppossum
(Monodelphis domestica)
Mammalia DNAJC1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC1 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJC1 35
  • 77.59 (n)
  • 77.45 (a)
DNAJC1 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJC1 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc1 35
  • 71.11 (n)
  • 72.12 (a)
Str.7061 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15036 35
zebrafish
(Danio rerio)
Actinopterygii dnajc1 35
  • 64.33 (n)
  • 63.93 (a)
Dr.7515 35
dnajc1 36
  • 58 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.932 35
fruit fly
(Drosophila melanogaster)
Insecta CG7556 36
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F54F2.9 35
  • 47.81 (n)
  • 37.79 (a)
F54F2.9 36
  • 35 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZUO1 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10456 36
  • 39 (a)
OneToOne
Species with no ortholog for DNAJC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC1 Gene

ENSEMBL:
Gene Tree for DNAJC1 (if available)
TreeFam:
Gene Tree for DNAJC1 (if available)

Paralogs for DNAJC1 Gene

Paralogs for DNAJC1 Gene

Selected SIMAP similar genes for DNAJC1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for DNAJC1 Gene

genes like me logo Genes that share paralogs with DNAJC1: view

Variants for DNAJC1 Gene

Sequence variations from dbSNP and Humsavar for DNAJC1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs9045 -- 21,759,401(-) ACAGC(A/G)AAGCC synonymous-codon, reference
rs792452 -- 21,865,308(-) ttcta(C/G)ttttt intron-variant
rs792453 -- 21,865,279(-) ctgct(A/G)tgaag intron-variant
rs792454 -- 21,902,452(+) GGCGC(A/C)CACCA intron-variant
rs792455 -- 21,904,493(+) TGACA(C/T)TGTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC1 Gene

Variant ID Type Subtype PubMed ID
nsv894947 CNV Loss 21882294
esv2665064 CNV Deletion 23128226
esv2511732 CNV Deletion 19546169
nsv507545 CNV Insertion 20534489
esv2669848 CNV Deletion 23128226
nsv831808 CNV Gain 17160897
esv273070 CNV Insertion 20981092
nsv894948 CNV Loss 21882294
nsv894949 CNV Loss 21882294

Relevant External Links for DNAJC1 Gene

HapMap Linkage Disequilibrium report
DNAJC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC1 Gene

Disorders for DNAJC1 Gene

Relevant External Links for DNAJC1

Genetic Association Database (GAD)
DNAJC1
Human Genome Epidemiology (HuGE) Navigator
DNAJC1

No disorders were found for DNAJC1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DNAJC1 Gene

Publications for DNAJC1 Gene

  1. The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity. (PMID: 14668352) Kroczynska B. … Blond S.Y. (J. Biol. Chem. 2004) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48

Products for DNAJC1 Gene

Sources for DNAJC1 Gene

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