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Aliases for DNAJB9 Gene

Aliases for DNAJB9 Gene

  • DnaJ (Hsp40) Homolog, Subfamily B, Member 9 2 3
  • MDG1 3 4 6
  • Microvascular Endothelial Differentiation Gene 1 Protein 3 4
  • Endoplasmic Reticulum DNA J Domain-Containing Protein 4 3 4
  • ER-Resident Protein ERdj4 3 4
  • MDG-1 3 4
  • ERdj4 3 4
  • Endoplasmic Reticulum DnaJ Homolog 4 3
  • DnaJ Homolog Subfamily B Member 9 3
  • MSTP049 3
  • MST049 3

External Ids for DNAJB9 Gene

Previous HGNC Symbols for DNAJB9 Gene

  • MDG1

Previous GeneCards Identifiers for DNAJB9 Gene

  • GC07P106694
  • GC07P107756
  • GC07P107770
  • GC07P107804
  • GC07P107997
  • GC07P108210
  • GC07P102578

Summaries for DNAJB9 Gene

Entrez Gene Summary for DNAJB9 Gene

  • This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. This gene is a member of the type 2 subgroup of DnaJ proteins. The encoded protein is localized to the endoplasmic reticulum. This protein is induced by endoplasmic reticulum stress and plays a role in protecting stressed cells from apoptosis. [provided by RefSeq, Dec 2010]

GeneCards Summary for DNAJB9 Gene

DNAJB9 (DnaJ (Hsp40) Homolog, Subfamily B, Member 9) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Unfolded Protein Response. GO annotations related to this gene include misfolded protein binding. An important paralog of this gene is DNAJB7.

UniProtKB/Swiss-Prot for DNAJB9 Gene

  • Involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Acts as a co-chaperone with an Hsp70 protein.

Gene Wiki entry for DNAJB9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB9 Gene

Genomics for DNAJB9 Gene

Regulatory Elements for DNAJB9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DNAJB9 Gene

Start:
108,569,568 bp from pter
End:
108,574,850 bp from pter
Size:
5,283 bases
Orientation:
Plus strand

Genomic View for DNAJB9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJB9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB9 Gene

Proteins for DNAJB9 Gene

  • Protein details for DNAJB9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBS3-DNJB9_HUMAN
    Recommended name:
    DnaJ homolog subfamily B member 9
    Protein Accession:
    Q9UBS3
    Secondary Accessions:

    Protein attributes for DNAJB9 Gene

    Size:
    223 amino acids
    Molecular mass:
    25518 Da
    Quaternary structure:
    • Interacts with DERL1.

    Three dimensional structures from OCA and Proteopedia for DNAJB9 Gene

neXtProt entry for DNAJB9 Gene

Proteomics data for DNAJB9 Gene at MOPED

Post-translational modifications for DNAJB9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJB9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJB9 Gene

Domains for DNAJB9 Gene

Gene Families for DNAJB9 Gene

HGNC:
  • DNAJ :Heat shock proteins / DNAJ (HSP40)

Protein Domains for DNAJB9 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9UBS3

UniProtKB/Swiss-Prot:

DNJB9_HUMAN :
  • Q9UBS3
Domain:
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJB9: view

Function for DNAJB9 Gene

Molecular function for DNAJB9 Gene

UniProtKB/Swiss-Prot Function: Involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Acts as a co-chaperone with an Hsp70 protein.

Gene Ontology (GO) - Molecular Function for DNAJB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19815549
GO:0051787 misfolded protein binding IDA 18400946
genes like me logo Genes that share ontologies with DNAJB9: view

Phenotypes for DNAJB9 Gene

GenomeRNAi human phenotypes for DNAJB9:
genes like me logo Genes that share phenotypes with DNAJB9: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJB9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DNAJB9 Gene

Localization for DNAJB9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJB9 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJB9 Gene COMPARTMENTS Subcellular localization image for DNAJB9 gene
Compartment Confidence
endoplasmic reticulum 4
nucleus 4
extracellular 3
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for DNAJB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus ISS --
GO:0005737 cytoplasm ISS --
GO:0005783 endoplasmic reticulum IDA --
GO:0005788 endoplasmic reticulum lumen IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with DNAJB9: view

Pathways for DNAJB9 Gene

genes like me logo Genes that share pathways with DNAJB9: view

PCR Array Products

Gene Ontology (GO) - Biological Process for DNAJB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006987 activation of signaling protein activity involved in unfolded protein response --
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IMP 18400946
GO:0030968 endoplasmic reticulum unfolded protein response TAS --
GO:0036498 IRE1-mediated unfolded protein response TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with DNAJB9: view

Transcripts for DNAJB9 Gene

mRNA/cDNA for DNAJB9 Gene

Unigene Clusters for DNAJB9 Gene

DnaJ (Hsp40) homolog, subfamily B, member 9:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJB9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2: - -
SP3:

Relevant External Links for DNAJB9 Gene

GeneLoc Exon Structure for
DNAJB9
ECgene alternative splicing isoforms for
DNAJB9

Expression for DNAJB9 Gene

mRNA expression in normal human tissues for DNAJB9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAJB9 Gene

This gene is overexpressed in Liver (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJB9 Gene

SOURCE GeneReport for Unigene cluster for DNAJB9 Gene Hs.741182

genes like me logo Genes that share expressions with DNAJB9: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DNAJB9 Gene

Orthologs for DNAJB9 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAJB9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJB9 35
  • 99.7 (n)
  • 99.55 (a)
DNAJB9 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAJB9 35
  • 93.09 (n)
  • 94.59 (a)
DNAJB9 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJB9 35
  • 93.99 (n)
  • 95.5 (a)
DNAJB9 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajb9 35
  • 91.44 (n)
  • 94.14 (a)
Dnajb9 16
Dnajb9 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNAJB9 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJB9 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajb9 35
  • 90.39 (n)
  • 93.24 (a)
chicken
(Gallus gallus)
Aves DNAJB9 35
  • 76.74 (n)
  • 75.81 (a)
DNAJB9 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJB9 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajb9 35
  • 72.85 (n)
  • 71.04 (a)
zebrafish
(Danio rerio)
Actinopterygii dnajb9a 35
  • 69.33 (n)
  • 69.01 (a)
dnajb9a 36
  • 68 (a)
OneToMany
dnajb9b 36
  • 65 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7130 36
  • 27 (a)
OneToOne
Species with no ortholog for DNAJB9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAJB9 Gene

ENSEMBL:
Gene Tree for DNAJB9 (if available)
TreeFam:
Gene Tree for DNAJB9 (if available)

Paralogs for DNAJB9 Gene

Selected SIMAP similar genes for DNAJB9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DNAJB9: view

Variants for DNAJB9 Gene

Sequence variations from dbSNP and Humsavar for DNAJB9 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1043615 -- 108,571,909(+) AGCCC(A/G)GATGC synonymous-codon, reference
rs2041003 -- 108,572,722(+) TCTGC(C/T)TTATT intron-variant
rs2286259 -- 108,574,488(+) TGATC(A/G)CAGGC utr-variant-3-prime
rs3763455 -- 108,573,687(-) TACAA(C/T)TAACT utr-variant-3-prime
rs3763456 -- 108,573,675(-) TTAAA(C/G)TTTAA utr-variant-3-prime

Relevant External Links for DNAJB9 Gene

HapMap Linkage Disequilibrium report
DNAJB9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DNAJB9 Gene

Disorders for DNAJB9 Gene

Relevant External Links for DNAJB9

Genetic Association Database (GAD)
DNAJB9
Human Genome Epidemiology (HuGE) Navigator
DNAJB9
genes like me logo Genes that share disorders with DNAJB9: view

No data available for UniProtKB/Swiss-Prot for DNAJB9 Gene

Publications for DNAJB9 Gene

  1. ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C. (PMID: 18400946) Dong M. … Weaver T.E. (Mol. Biol. Cell 2008) 3 4 23
  2. HLA-B35 upregulates endothelin-1 and downregulates endothelial nitric oxide synthase via endoplasmic reticulum stress response in endothelial cells. (PMID: 20335527) Lenna S. … Scorza R. (J. Immunol. 2010) 3 23
  3. Assignment of the microvascular endothelial differentiation gene 1 (MDG1) to human chromosome band 14q24.2-->q24.3 by fluorescence in situ hybridization. (PMID: 9533036) PrAPls F. … Rautenstrauss B. (Cytogenet. Cell Genet. 1997) 2 3
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  5. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K. … Hata M. (Cell Stress Chaperones 2000) 2 3

Products for DNAJB9 Gene

Sources for DNAJB9 Gene

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