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Aliases for DNAJB9 Gene

Aliases for DNAJB9 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member B9 2 3 5
  • Microvascular Endothelial Differentiation Gene 1 Protein 3 4
  • Endoplasmic Reticulum DNA J Domain-Containing Protein 4 3 4
  • DnaJ (Hsp40) Homolog, Subfamily B, Member 9 2 3
  • ER-Resident Protein ERdj4 3 4
  • MDG-1 3 4
  • ERdj4 3 4
  • MDG1 3 4
  • Endoplasmic Reticulum DnaJ Homolog 4 3
  • MSTP049 3
  • MST049 3

External Ids for DNAJB9 Gene

Previous HGNC Symbols for DNAJB9 Gene

  • MDG1

Previous GeneCards Identifiers for DNAJB9 Gene

  • GC07P106694
  • GC07P107756
  • GC07P107770
  • GC07P107804
  • GC07P107997
  • GC07P108210
  • GC07P102578

Summaries for DNAJB9 Gene

Entrez Gene Summary for DNAJB9 Gene

  • This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. This gene is a member of the type 2 subgroup of DnaJ proteins. The encoded protein is localized to the endoplasmic reticulum. This protein is induced by endoplasmic reticulum stress and plays a role in protecting stressed cells from apoptosis. [provided by RefSeq, Dec 2010]

GeneCards Summary for DNAJB9 Gene

DNAJB9 (DnaJ Heat Shock Protein Family (Hsp40) Member B9) is a Protein Coding gene. Among its related pathways are Unfolded Protein Response (UPR) and Transport to the Golgi and subsequent modification. GO annotations related to this gene include misfolded protein binding. An important paralog of this gene is DNAJB7.

UniProtKB/Swiss-Prot for DNAJB9 Gene

  • Involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Acts as a co-chaperone with an Hsp70 protein.

Gene Wiki entry for DNAJB9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB9 Gene

Genomics for DNAJB9 Gene

Regulatory Elements for DNAJB9 Gene

Enhancers for DNAJB9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DNAJB9 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJB9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DNAJB9 on UCSC Golden Path with GeneCards custom track

Genomic Location for DNAJB9 Gene

108,569,568 bp from pter
108,574,850 bp from pter
5,283 bases
Plus strand

Genomic View for DNAJB9 Gene

Genes around DNAJB9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJB9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJB9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB9 Gene

Proteins for DNAJB9 Gene

  • Protein details for DNAJB9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily B member 9
    Protein Accession:

    Protein attributes for DNAJB9 Gene

    223 amino acids
    Molecular mass:
    25518 Da
    Quaternary structure:
    • Interacts with DERL1.

    Three dimensional structures from OCA and Proteopedia for DNAJB9 Gene

neXtProt entry for DNAJB9 Gene

Proteomics data for DNAJB9 Gene at MOPED

Post-translational modifications for DNAJB9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJB9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJB9 Gene

Domains & Families for DNAJB9 Gene

Gene Families for DNAJB9 Gene

Protein Domains for DNAJB9 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 J domain.
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJB9: view

Function for DNAJB9 Gene

Molecular function for DNAJB9 Gene

UniProtKB/Swiss-Prot Function:
Involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Acts as a co-chaperone with an Hsp70 protein.
genes like me logo Genes that share phenotypes with DNAJB9: view

Animal Model Products

CRISPR Products

miRNA for DNAJB9 Gene

miRTarBase miRNAs that target DNAJB9

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJB9 Gene

Localization for DNAJB9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJB9 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

Jensen Localization Image for DNAJB9 Gene COMPARTMENTS Subcellular localization image for DNAJB9 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
nucleus 5
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for DNAJB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA,ISS --
GO:0005737 cytoplasm IEA,ISS --
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with DNAJB9: view

Pathways & Interactions for DNAJB9 Gene

genes like me logo Genes that share pathways with DNAJB9: view

Gene Ontology (GO) - Biological Process for DNAJB9 Gene


No data available for SIGNOR curated interactions for DNAJB9 Gene

Drugs & Compounds for DNAJB9 Gene

No Compound Related Data Available

Transcripts for DNAJB9 Gene

mRNA/cDNA for DNAJB9 Gene

Unigene Clusters for DNAJB9 Gene

DnaJ (Hsp40) homolog, subfamily B, member 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2: - -

Relevant External Links for DNAJB9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJB9 Gene

mRNA expression in normal human tissues for DNAJB9 Gene

mRNA differential expression in normal tissues according to GTEx for DNAJB9 Gene

This gene is overexpressed in Liver (x4.8).

Protein differential expression in normal tissues from HIPED for DNAJB9 Gene

This gene is overexpressed in Liver (18.0), Testis (13.9), and Ovary (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJB9 Gene

SOURCE GeneReport for Unigene cluster for DNAJB9 Gene Hs.741182

genes like me logo Genes that share expression patterns with DNAJB9: view

Protein tissue co-expression partners for DNAJB9 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DNAJB9 Gene

Orthologs for DNAJB9 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAJB9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DNAJB9 35
  • 93.09 (n)
  • 94.59 (a)
  • 94 (a)
(Canis familiaris)
Mammalia DNAJB9 35
  • 93.99 (n)
  • 95.5 (a)
  • 95 (a)
(Mus musculus)
Mammalia Dnajb9 35
  • 91.44 (n)
  • 94.14 (a)
Dnajb9 16
Dnajb9 36
  • 94 (a)
(Pan troglodytes)
Mammalia DNAJB9 35
  • 99.7 (n)
  • 99.55 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Dnajb9 35
  • 90.39 (n)
  • 93.24 (a)
(Monodelphis domestica)
Mammalia DNAJB9 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia DNAJB9 36
  • 81 (a)
(Gallus gallus)
Aves DNAJB9 35
  • 76.74 (n)
  • 75.81 (a)
  • 76 (a)
(Anolis carolinensis)
Reptilia DNAJB9 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajb9 35
  • 72.85 (n)
  • 71.04 (a)
(Danio rerio)
Actinopterygii dnajb9a 35
  • 69.33 (n)
  • 69.01 (a)
dnajb9a 36
  • 68 (a)
dnajb9b 36
  • 65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7130 36
  • 27 (a)
Species with no ortholog for DNAJB9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAJB9 Gene

Gene Tree for DNAJB9 (if available)
Gene Tree for DNAJB9 (if available)

Paralogs for DNAJB9 Gene

(7) SIMAP similar genes for DNAJB9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DNAJB9: view

Variants for DNAJB9 Gene

Sequence variations from dbSNP and Humsavar for DNAJB9 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs17155937 - 108,573,088(+) GAAGC(A/G)TTTTG reference, missense
rs1043615 -- 108,571,909(+) AGCCC(A/G)GATGC reference, synonymous-codon
rs2041003 -- 108,572,722(+) TCTGC(C/T)TTATT intron-variant
rs2286259 -- 108,574,488(+) TGATC(A/G)CAGGC utr-variant-3-prime
rs35515962 -- 108,574,646(+) TCCTA(A/G)GAGCA utr-variant-3-prime

Variation tolerance for DNAJB9 Gene

Residual Variation Intolerance Score: 58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.35% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for DNAJB9 Gene

Disorders for DNAJB9 Gene

Relevant External Links for DNAJB9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DNAJB9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJB9 Gene

Publications for DNAJB9 Gene

  1. ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C. (PMID: 18400946) Dong M. … Weaver T.E. (Mol. Biol. Cell 2008) 3 4 23 67
  2. HLA-B35 upregulates endothelin-1 and downregulates endothelial nitric oxide synthase via endoplasmic reticulum stress response in endothelial cells. (PMID: 20335527) Lenna S. … Scorza R. (J. Immunol. 2010) 3 23
  3. XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. (PMID: 14559994) Lee A.H. … Glimcher L.H. (Mol. Cell. Biol. 2003) 3 23
  4. Identification and characterization of a novel endoplasmic reticulum (ER) DnaJ homologue, which stimulates ATPase activity of BiP in vitro and is induced by ER stress. (PMID: 11836248) Shen Y. … Hendershot L.M. (J. Biol. Chem. 2002) 3 23
  5. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K. … Hata M. (Cell Stress Chaperones 2000) 2 3

Products for DNAJB9 Gene

Sources for DNAJB9 Gene