DNAJB9 Gene
protein-coding GIFtS: 53
GCID: GC07P108210
|
|
DnaJ (Hsp40) homolog, subfamily B, member 9 (Previous symbol: MDG1)
| |
Aliases for DNAJB9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| DnaJ (Hsp40) Homolog, Subfamily B, Member 91 2 | | MST0492 | | MDG11 2 3 5 | | MSTP0492 | | Microvascular Endothelial Differentiation Gene 1 Protein2 3 | | DnaJ Homolog Subfamily B Member 92 | | ERdj42 | | Endoplasmic Reticulum DnaJ Homolog 42 | | MDG-12 | | Mdg-13 |
Export aliases for DNAJB9 gene to outside databasesPrevious GC identifers: GC07P106694 GC07P107756 GC07P107770 GC07P107804 GC07P107997 GC07P102578 |
Summaries for DNAJB9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for DNAJB9: This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPaseactivity of 70 kDa heat shock proteins. This gene is a member of the type 2 subgroup of DnaJ proteins. The encodedprotein is localized to the endoplasmic reticulum. This protein is induced by endoplasmic reticulum stress and plays arole in protecting stressed cells from apoptosis. (provided by RefSeq, Dec 2010) UniProtKB/Swiss-Prot: DNJB9_HUMAN, Q9UBS3Function: Acts as a co-chaperone with an Hsp70 protein (By similarity) Gene Wiki entry for DNAJB9
|
Genomic Views for DNAJB9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DNAJB9 gene promoter: CBF-A CBF-B POU2F1 POU2F1a Pax-2 Pax-2a Nkx2-5 CBF(2) Other transcription factors
Search SABiosciences Chromatin IP Primers for DNAJB9
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJB9 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q31|14q24.2-q24.3 Ensembl cytogenetic band: 7q31.1 HGNC cytogenetic band: 7q31DNAJB9 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P108210: view genomic region
(about GC identifiers)
Start:
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108,210,012 bp from pter |
End:
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108,215,294 bp from pter |
Size:
|
5,283 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 107,577,570-107,582,508 |
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Proteins for DNAJB9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: DNJB9_HUMAN, Q9UBS3 (See
protein sequence)Recommended Name: DnaJ homolog subfamily B member 9 Size: 223 amino acids; 25518 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=Stress induces its translocation to thenucleus (By similarity)
1 PDB 3D structure from and Proteopedia for DNAJB9:2CTR (3D)
 Explore the universe of human proteins at neXtProt for DNAJB9: NX_Q9UBS3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UBS3 DNAJB9 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036460.1 ENSEMBL proteins: ENSP00000249356 Reactome Protein details: Q9UBS3 Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
DNAJB9 for ontologies About GeneDecksing
DNAJB9 Antibody Products: Assay Products for DNAJB9: |
Protein
Domains / Families for DNAJB9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DNAJB9 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UBS3ProtoNet protein and cluster: Q9UBS3 UniProtKB/Swiss-Prot: DNJB9_HUMAN, Q9UBS3Similarity: Contains 1 J domain |
Function for DNAJB9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: DNJB9_HUMAN, Q9UBS3Function: Acts as a co-chaperone with an Hsp70 protein (By similarity)
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJB9 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJB9 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB9 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
DNAJB9 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for DNAJB9:
|
Pathways & Interactions for DNAJB9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Activation of Chaperone Genes by XBP1(S) | | | 2 | Expression of DNAJB9 | | | 3 | Asparagine N-linked glycosylation | |
Pathway sources See GeneCards unified pathways Show all pathways
5
Reactome Pathways for DNAJB9
DNAJB9 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DNAJB9
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
 5/17 Interacting proteins for DNAJB9 (Q9UBS32, 3 ENSP000002493564) via UniProtKB, MINT, STRING, and/or I2D (see all 17)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006457 | protein folding |
IEA | -- | | GO:0006987 | activation of signaling protein activity involved in unfolded protein response |
TAS | -- | | GO:0030433 | ER-associated protein catabolic process |
IMP | 18400946 | | GO:0030968 | endoplasmic reticulum unfolded protein response |
TAS | -- |
DNAJB9 for ontologies About GeneDecksing
|
Drugs & Compounds for DNAJB9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for DNAJB9 Search CenterWatch for drugs/clinical trials and news about DNAJB9 / DNJB9 
|
Transcripts for DNAJB9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for DNAJB9 gene: NM_012328.2 Unigene Cluster for DNAJB9: DnaJ (Hsp40) homolog, subfamily B, member 9 Hs.741182 [show with all ESTs]Unigene Representative Sequence: NM_0123283 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000249356(uc003vfn.3) ENST00000491582 ENST00000465725
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJB9 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNAJB9 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DNAJB9 (NM_012328) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DNAJB9 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNAJB9  |
Additional cDNA sequence: AB026908.1 AF083247.1 AF093824.1 AK092204.1 AL080081.1 AY359045.1 BC028912.1 CR533475.1 12 DOTS entries: DT.101975427 DT.316837 DT.100795998 DT.100027735 DT.121054184 DT.100796000 DT.121054166 DT.100795996 DT.100795999 DT.121054196 DT.95115040 DT.313445 24/260 AceView cDNA sequences (see all 260): AA918038 AA383230 NM_012328 BP369159 BQ271559 BM975416 AA815051 AI299527 BM263441 AA398180 AI683522 CF541311 AI457520 BF593583 BM805701 AA973531 C17028 AI889643 AI281873 AW779606 CB321773 BQ773823 AI479500 AI814803 GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB9 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | |
| SP1: | |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | - |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for DNAJB9
|
Expression for DNAJB9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DNAJB9 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AAACTGTATA
About this image See DNAJB9 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DNAJB9
SOURCE GeneReport for Unigene cluster: Hs.741182 SABiosciences Expression via Pathway-Focused PCR Arrays including DNAJB9:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNAJB9 Browse OriGene validated miRNA SYBR primer pairs
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| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB9 |
Orthologs for DNAJB9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DNAJB9 gene from 6/20 species (see all 20) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
DNAJB91 |
DnaJ (Hsp40) homolog, subfamily B, member 9 |
76.74(n) 75.81(a) |
  |
417783 NM_001030735.1 NP_001025906.1 |
lizard (Anolis carolinensis) |
Reptilia |
DNAJB96 |
-- |
78(a) |
1 ↔ 1 |
1(133496868-133499138) |
African clawed frog (Xenopus laevis) |
Amphibia |
BC046936.12 |
-- |
82.43(n) |
  |
BC046936.1 |
zebrafish (Danio rerio) |
Actinopterygii |
zgc:1141621 |
zgc:114162 |
69.33(n) 69.01(a) |
  |
574005 NM_001025184.1 NP_001020355.1 |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
ATERDJ3A6 |
DnaJ domain-containing protein |
8(a) |
1 ↔ 1 |
3(2737537-2740530) |
rice (Oryza sativa) |
Liliopsida |
-- |
heat shock protein DnaJ, putative, expressed |
7(a) |
1 ↔ 1 |
3(10203735-10209222) |
ENSEMBL Gene Tree for DNAJB9 (if available) TreeFam Gene Tree for DNAJB9 (if available)  |
Paralogs for DNAJB9 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for DNAJB9 gene
- DNAJB42 DNAJC32 DNAJB52 DNAJB132 DNAJB22 DNAJC112 DNAJB62 DNAJC72
- DNAJB12 DNAJB72 DNAJB82
7 SIMAP similar genes for DNAJB9 using alignment to 2 protein entries: DNJB9_HUMAN (see all proteins):DNAJB12 DNAJB6 DNAJB4 DNAJA3 DNAJB5 DNAJB1 WUGSC
DNAJB9 for paralogs About GeneDecksing
|
Genomic Variants for DNAJB9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 7 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for DNAJB9 (108210012 - 108215294 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for DNAJB9: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNAJB9 |
|
Disorders
/ Diseases for DNAJB9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DNAJB9 for disorders About GeneDecksing
OMIM gene information: 602634
OMIM disorders: --
2 diseases for DNAJB9: About MalaCardsglioblastoma malaria Human Genome Epidemiology (HuGE) Navigator: DNAJB9 (1 document) Export disorders for DNAJB9 gene to outside databases
|
Publications for DNAJB9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DNAJB9 gene, integrated from 9 sources (see all 35): (articles sorted by number of sources associating them with DNAJB9) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PubMed id 11147971)1, 3 Ohtsuka K. and Hata M. (2000)
- Assignment of the microvascular endothelial differentiation gene 1 (MDG1) to human chromosome band 14q24.2-->q24.3 by fluorescence in situ hybridization. (PubMed id 9533036)1, 3 Prols F....Rautenstrauss B. (1997)
- ERdj4 and ERdj5 Are Required for Endoplasmic Reticulum-associated Protein Degradation of Misfolded Surfactant Protein C. (PubMed id 18400946)1, 9 Dong M....Weaver T.E. (2008)
- Identification and characterization of a novel endoplasmic reticulum (ER) DnaJ homologue, which stimulates ATPase activity of BiP in vitro and is induced by ER stress. (PubMed id 11836248)1, 9 Shen Y....Hendershot L.M. (2002)
- HLA-B35 upregulates endothelin-1 and downregulates en dothelial nitric oxide synthase via endoplasmic reticulum stress response in en dothelial cells. (PubMed id 20335527)1, 9 Lenna S....Scorza R. (2010)
- XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. (PubMed id 14559994)1, 9 Lee A.H....Glimcher L.H. (2003)
|
External Searches for DNAJB9 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing DNAJB9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DNAJB9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DNAJB9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for DNAJB9 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DNAJB9 gene: Search GeneIP for patents involving DNAJB9
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for DNAJB9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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