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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DNAJB9 Gene

protein-coding   GIFtS: 53
GCID: GC07P108210

DnaJ (Hsp40) homolog, subfamily B, member 9


(Previous symbol: MDG1)
 Explore 2 diseases affiliated with
DNAJB9 via our new
 Human Malady Compendium 
Biological research products
for DNAJB9
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
DnaJ (Hsp40) Homolog, Subfamily B, Member 91 2     MST0492
MDG11 2 3 5     MSTP0492
Microvascular Endothelial Differentiation Gene 1 Protein2 3     DnaJ Homolog Subfamily B Member 92
ERdj42     Endoplasmic Reticulum DnaJ Homolog 42
MDG-12     Mdg-13

External Ids:    HGNC: 69681   Entrez Gene: 41892   Ensembl: ENSG000001285907   OMIM: 6026345   UniProtKB: Q9UBS33   

Export aliases for DNAJB9 gene to outside databases

Previous GC identifers: GC07P106694 GC07P107756 GC07P107770 GC07P107804 GC07P107997 GC07P102578


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DNAJB9:
This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase
activity of 70 kDa heat shock proteins. This gene is a member of the type 2 subgroup of DnaJ proteins. The encoded
protein is localized to the endoplasmic reticulum. This protein is induced by endoplasmic reticulum stress and plays a
role in protecting stressed cells from apoptosis. (provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: DNJB9_HUMAN, Q9UBS3
Function: Acts as a co-chaperone with an Hsp70 protein (By similarity)

Gene Wiki entry for DNAJB9


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DNAJB9 gene promoter:
         CBF-A   CBF-B   POU2F1   POU2F1a   Pax-2   Pax-2a   Nkx2-5   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): DNAJB9 promoter sequence
   Search SABiosciences Chromatin IP Primers for DNAJB9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNAJB9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31|14q24.2-q24.3   Ensembl cytogenetic band:  7q31.1   HGNC cytogenetic band: 7q31

DNAJB9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJB9 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P108210:  view genomic region     (about GC identifiers)

Start:
108,210,012 bp from pter      End:
108,215,294 bp from pter
Size:
5,283 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 107,577,570-107,582,508     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DNJB9_HUMAN, Q9UBS3 (See protein sequence)
Recommended Name: DnaJ homolog subfamily B member 9  
Size: 223 amino acids; 25518 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=Stress induces its translocation to the
nucleus (By similarity)
1 PDB 3D structure from and Proteopedia for DNAJB9:
2CTR (3D)    

Explore the universe of human proteins at neXtProt for DNAJB9: NX_Q9UBS3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UBS3

  • DNAJB9 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036460.1  
    ENSEMBL proteins: 
     ENSP00000249356  
    Reactome Protein details: Q9UBS3
    Human Recombinant Protein Products: 
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    Novus Biologicals DNAJB9 Proteins
    Novus Biologicals DNAJB9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DNAJB9

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane TAS--


    DNAJB9 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    DNAJB9 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001623 DnaJ_domain
     IPR018253 DnaJ_domain_CS

    Graphical View of Domain Structure for InterPro Entry Q9UBS3

    ProtoNet protein and cluster: Q9UBS3

    UniProtKB/Swiss-Prot: DNJB9_HUMAN, Q9UBS3
    Similarity: Contains 1 J domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: DNJB9_HUMAN, Q9UBS3
    Function: Acts as a co-chaperone with an Hsp70 protein (By similarity)

    miRNA
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    hsa-miR-193a-3p hsa-miR-429 hsa-let-7d hsa-miR-106a hsa-miR-513a-5p hsa-miR-25 hsa-miR-519a hsa-miR-374c
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    Inhib. RNA
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19815549
    GO:0031072heat shock protein binding IEA--
    GO:0051082unfolded protein binding IEA--
    GO:0051787misfolded protein binding IDA18400946


    DNAJB9 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for DNAJB9:
     Increased G1 DNA content  Increased cell size 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of Chaperone Genes by XBP1(S)
    Activation of Chaperone Genes by XBP1(S)1.00
    Unfolded Protein Response0.71
    Activation of Chaperones by IRE1alpha0.94
    2Expression of DNAJB9
    Expression of DNAJB91.00
    3Asparagine N-linked glycosylation
    Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for DNAJB9
        Activation of Chaperone Genes by XBP1(S)
    Expression of DNAJB9
    Metabolism of proteins
    Activation of Chaperones by IRE1alpha
    Unfolded Protein Response



    DNAJB9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DNAJB9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/17 Interacting proteins for DNAJB9 (Q9UBS32, 3 ENSP000002493564) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYL6P606602, 3, ENSP000002934224MINT-65685 I2D: score=4 STRING: ENSP00000293422
    PLK1P533502, 3MINT-65684 I2D: score=5 
    SLC16A8O959072, 3MINT-65683 I2D: score=5 
    DYNLL1P631672, 3MINT-65686 I2D: score=4 
    RFKQ969G62, 3MINT-65688 I2D: score=4 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0030433ER-associated protein catabolic process IMP18400946
    GO:0030968endoplasmic reticulum unfolded protein response TAS--


    DNAJB9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DNAJB9
    Search CenterWatch for drugs/clinical trials and news about DNAJB9 / DNJB9 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DNAJB9 gene: 
    NM_012328.2  

    Unigene Cluster for DNAJB9:

    DnaJ (Hsp40) homolog, subfamily B, member 9
    Hs.741182  [show with all ESTs]
    Unigene Representative Sequence: NM_012328
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000249356(uc003vfn.3) ENST00000491582 ENST00000465725

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    hsa-miR-193a-3p hsa-miR-429 hsa-let-7d hsa-miR-106a hsa-miR-513a-5p hsa-miR-25 hsa-miR-519a hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidDNAJB9 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNAJB9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNAJB9

    Additional cDNA sequence: 

    AB026908.1 AF083247.1 AF093824.1 AK092204.1 AL080081.1 AY359045.1 BC028912.1 CR533475.1 

    12 DOTS entries:

    DT.101975427  DT.316837  DT.100795998  DT.100027735  DT.121054184  DT.100796000  DT.121054166  DT.100795996 
    DT.100795999  DT.121054196  DT.95115040  DT.313445 

    24/260 AceView cDNA sequences (see all 260):

    AA918038 AA383230 NM_012328 BP369159 BQ271559 BM975416 AA815051 AI299527 
    BM263441 AA398180 AI683522 CF541311 AI457520 BF593583 BM805701 AA973531 
    C17028 AI889643 AI281873 AW779606 CB321773 BQ773823 AI479500 AI814803 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB9    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b
    SP1:                                -               
    SP2:                    -           -               
    SP3:                                                


    ECgene alternative splicing isoforms for DNAJB9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DNAJB9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAACTGTATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See DNAJB9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DNAJB9

    SOURCE GeneReport for Unigene cluster: Hs.741182
        SABiosciences Expression via Pathway-Focused PCR Arrays including DNAJB9: 
              Cellular Stress Responses in human mouse rat
              Unfolded Protein Response in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNAJB9 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves DNAJB91 DnaJ (Hsp40) homolog, subfamily B, member 9 76.74(n)
    75.81(a)
      417783  NM_001030735.1  NP_001025906.1 
    lizard
    (Anolis carolinensis)
    Reptilia DNAJB96
    --
    78(a)
    1 ↔ 1
    1(133496868-133499138)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC046936.12   -- 82.43(n)    BC046936.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1141621 zgc:114162 69.33(n)
    69.01(a)
      574005  NM_001025184.1  NP_001020355.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATERDJ3A6
    DnaJ domain-containing protein
    8(a)
    1 ↔ 1
    3(2737537-2740530)
    rice
    (Oryza sativa)
    Liliopsida --
    heat shock protein DnaJ, putative, expressed
    7(a)
    1 ↔ 1
    3(10203735-10209222)


    ENSEMBL Gene Tree for DNAJB9 (if available)
    TreeFam Gene Tree for DNAJB9 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DNAJB9 gene
    DNAJB42  DNAJC32  DNAJB52  DNAJB132  DNAJB22  DNAJC112  DNAJB62  DNAJC72  
    DNAJB12  DNAJB72  DNAJB82  
    7 SIMAP similar genes for DNAJB9 using alignment to 2 protein entries:     DNJB9_HUMAN (see all proteins):
    DNAJB12    DNAJB6    DNAJB4    DNAJA3    DNAJB5    DNAJB1
    WUGSC

    DNAJB9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/130 NCBI SNPs in DNAJB9 are shown (see all 130    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs734281081,2
    C,--108208382(+) GTTTAG/CTTAAA 3 -- int1 us2k12Minor allele frequency- C:0.06WA 120
    rs1906259331,2
    --108208538(+) ACTGAA/TAGTGG 3 -- int1 us2k10--------
    rs1831556811,2
    --108208576(+) CTCTTC/TGCATC 3 -- us2k1 int10--------
    rs102583441,2
    C,F,H,--108208587(+) TTGAGG/CCTGGG 3 -- us2k1 int113Minor allele frequency- C:0.26NS EA NA WA CSA 786
    rs1131993651,2
    --108208619(+) AAATAC/TTGCCA 3 -- us2k1 int11Minor allele frequency- T:0.50CSA 2
    rs2017896901,2
    --108208652(+) ATCAG-/TTTTTT 3 -- int1 us2k10--------
    rs1888535861,2
    --108208665(+) TTCTTA/TTGAGA 3 -- us2k1 int10--------
    rs1909090551,2
    --108208736(+) CCTCCA/CCCTCC 3 -- us2k1 int10--------
    rs409481,2
    C,F,--108208802(+) GCGCCG/ACCACG 3 -- int1 us2k1 tfbs39Minor allele frequency- A:0.33NA WA CSA EA 370
    rs1467037151,2
    --108208834(+) AGTACA/GGACGG 3 -- us2k1 int10--------

    HapMap Linkage Disequilibrium report for DNAJB9 (108210012 - 108215294 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DNAJB9: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNAJB9
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAJB9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DNAJB9 for disorders           About GeneDecksing

    OMIM gene information: 602634    OMIM disorders: --

    2 diseases for DNAJB9:    About MalaCards
    glioblastoma    malaria

    Human Genome Epidemiology (HuGE) Navigator: DNAJB9 (1 document)

    Export disorders for DNAJB9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DNAJB9 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with DNAJB9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    5. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PubMed id 11147971)1, 3 Ohtsuka K. and Hata M. (2000)
    6. Assignment of the microvascular endothelial differentiation gene 1 (MDG1) to human chromosome band 14q24.2-->q24.3 by fluorescence in situ hybridization. (PubMed id 9533036)1, 3 Prols F....Rautenstrauss B. (1997)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4189 HGNC: 6968 AceView: DNAJB9 Ensembl:ENSG00000128590 euGenes: HUgn4189
    ECgene: DNAJB9 H-InvDB: DNAJB9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DNAJB9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNAJB9 gene:
    Search GeneIP for patents involving DNAJB9

    GeneCards and IP:
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