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Aliases for DNAJB8 Gene

Aliases for DNAJB8 Gene

  • DnaJ (Hsp40) Homolog, Subfamily B, Member 8 2 3
  • DJ6 3 6
  • DnaJ Homolog Subfamily B Member 8 3
  • CT156 3

External Ids for DNAJB8 Gene

Previous GeneCards Identifiers for DNAJB8 Gene

  • GC03M129502
  • GC03M129663
  • GC03M128181
  • GC03M125565

Summaries for DNAJB8 Gene

Entrez Gene Summary for DNAJB8 Gene

  • The protein encoded by this gene belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity. This family member suppresses aggregation and toxicity of polyglutamine proteins, and the C-terminal tail is essential for this activity. It has been implicated as a cancer-testis antigen and as a cancer stem-like cell antigen involved in renal cell carcinoma. [provided by RefSeq, Jun 2012]

GeneCards Summary for DNAJB8 Gene

DNAJB8 (DnaJ (Hsp40) Homolog, Subfamily B, Member 8) is a Protein Coding gene. Diseases associated with DNAJB8 include renal cell carcinoma. GO annotations related to this gene include protein binding involved in protein folding. An important paralog of this gene is DNAJB7.

UniProtKB/Swiss-Prot for DNAJB8 Gene

  • Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB8 Gene

Genomics for DNAJB8 Gene

Regulatory Elements for DNAJB8 Gene

Genomic Location for DNAJB8 Gene

Start:
128,462,432 bp from pter
End:
128,467,248 bp from pter
Size:
4,817 bases
Orientation:
Minus strand

Genomic View for DNAJB8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB8 Gene

Proteins for DNAJB8 Gene

  • Protein details for DNAJB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHS0-DNJB8_HUMAN
    Recommended name:
    DnaJ homolog subfamily B member 8
    Protein Accession:
    Q8NHS0
    Secondary Accessions:
    • B3KWV7

    Protein attributes for DNAJB8 Gene

    Size:
    232 amino acids
    Molecular mass:
    25686 Da
    Quaternary structure:
    • Interacts with histone deacetylases HDAC4, HDAC6, and SIRT2, HDAC activity is required for antiaggregation.

    Three dimensional structures from OCA and Proteopedia for DNAJB8 Gene

neXtProt entry for DNAJB8 Gene

Proteomics data for DNAJB8 Gene at MOPED

Post-translational modifications for DNAJB8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJB8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DNAJB8 Gene

Domains for DNAJB8 Gene

Gene Families for DNAJB8 Gene

HGNC:
  • DNAJ :Heat shock proteins / DNAJ (HSP40)

Protein Domains for DNAJB8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DNAJB8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHS0

UniProtKB/Swiss-Prot:

DNJB8_HUMAN :
  • Q8NHS0
Domain:
  • The antiaggregation activity resides in the serine-rich region and the C-terminus
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJB8: view

Function for DNAJB8 Gene

Molecular function for DNAJB8 Gene

UniProtKB/Swiss-Prot Function:
Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins.

Gene Ontology (GO) - Molecular Function for DNAJB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044183 protein binding involved in protein folding IDA 23612975
GO:0051082 unfolded protein binding IDA 21231916
GO:0051087 chaperone binding IPI 21231916
genes like me logo Genes that share ontologies with DNAJB8: view

Phenotypes for DNAJB8 Gene

GenomeRNAi human phenotypes for DNAJB8:
genes like me logo Genes that share phenotypes with DNAJB8: view

Animal Model Products

miRNA for DNAJB8 Gene

miRTarBase miRNAs that target DNAJB8

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJB8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DNAJB8 Gene

Localization for DNAJB8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJB8 Gene COMPARTMENTS Subcellular localization image for DNAJB8 gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DNAJB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21231916
GO:0005829 cytosol IDA 21231916
genes like me logo Genes that share ontologies with DNAJB8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DNAJB8 Gene

Pathways for DNAJB8 Gene

SuperPathways for DNAJB8 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DNAJB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0061077 chaperone-mediated protein folding IDA 23612975
GO:0090084 negative regulation of inclusion body assembly IDA 21231916
genes like me logo Genes that share ontologies with DNAJB8: view

No data available for Pathways by source for DNAJB8 Gene

Transcripts for DNAJB8 Gene

mRNA/cDNA for DNAJB8 Gene

(21) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DNAJB8 Gene

DnaJ (Hsp40) homolog, subfamily B, member 8:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJB8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB8 Gene

ExUns: 1a · 1b ^ 2 ^ 3
SP1:
SP2:

Relevant External Links for DNAJB8 Gene

GeneLoc Exon Structure for
DNAJB8
ECgene alternative splicing isoforms for
DNAJB8

Expression for DNAJB8 Gene

mRNA expression in normal human tissues for DNAJB8 Gene

mRNA differential expression in normal tissues according to GTEx for DNAJB8 Gene

This gene is overexpressed in Testis (52.4).

Protein differential expression in normal tissues for DNAJB8 Gene

This gene is overexpressed in Ovary (33.4), Brain (16.6), Urine (11.3), and Testis (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJB8 Gene

SOURCE GeneReport for Unigene cluster for DNAJB8 Gene Hs.518241

genes like me logo Genes that share expressions with DNAJB8: view

Expression partners for DNAJB8 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DNAJB8 Gene

Orthologs for DNAJB8 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAJB8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNAJB8 35
  • 84.99 (n)
  • 87.01 (a)
DNAJB8 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJB8 35
  • 86.21 (n)
  • 88.36 (a)
DNAJB8 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajb8 35
  • 75.96 (n)
  • 80.97 (a)
Dnajb8 16
Dnajb8 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DNAJB8 35
  • 99.14 (n)
  • 98.71 (a)
DNAJB8 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajb8 35
  • 78.55 (n)
  • 86.09 (a)
oppossum
(Monodelphis domestica)
Mammalia DNAJB8 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJB8 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJB8 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJB8 36
  • 62 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:152986 36
  • 29 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta mrj 36
  • 28 (a)
OneToMany
Species with no ortholog for DNAJB8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAJB8 Gene

ENSEMBL:
Gene Tree for DNAJB8 (if available)
TreeFam:
Gene Tree for DNAJB8 (if available)

Paralogs for DNAJB8 Gene

Selected SIMAP similar genes for DNAJB8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DNAJB8: view

Variants for DNAJB8 Gene

Sequence variations from dbSNP and Humsavar for DNAJB8 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
VAR_033881 -

Structural Variations from Database of Genomic Variants (DGV) for DNAJB8 Gene

Variant ID Type Subtype PubMed ID
dgv1493e1 CNV Complex 17122850
dgv1494e1 CNV Complex 17122850
nsv508240 CNV Loss 20534489
dgv5250n71 CNV Loss 21882294
nsv516926 CNV Loss 19592680
nsv470905 CNV Loss 18288195
nsv877464 CNV Loss 21882294

Relevant External Links for DNAJB8 Gene

HapMap Linkage Disequilibrium report
DNAJB8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJB8 Gene

Disorders for DNAJB8 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for DNAJB8 Gene in MalaCards »

(1) Diseases for DNAJB8 Gene including...

genes like me logo Genes that share disorders with DNAJB8: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for DNAJB8 Gene

Publications for DNAJB8 Gene

  1. A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation. (PMID: 20159555) Hageman J. … Kampinga H.H. (Mol. Cell 2010) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K. … Hata M. (Cell Stress Chaperones 2000) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for DNAJB8 Gene

Sources for DNAJB8 Gene

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