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Aliases for DNAJB8 Gene

Aliases for DNAJB8 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member B8 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily B, Member 8 2 3
  • DnaJ Homolog Subfamily B Member 8 3
  • Testicular Tissue Protein Li 56 3
  • CT156 3
  • DJ6 3

External Ids for DNAJB8 Gene

Previous GeneCards Identifiers for DNAJB8 Gene

  • GC03M129502
  • GC03M129663
  • GC03M128181
  • GC03M125565

Summaries for DNAJB8 Gene

Entrez Gene Summary for DNAJB8 Gene

  • The protein encoded by this gene belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity. This family member suppresses aggregation and toxicity of polyglutamine proteins, and the C-terminal tail is essential for this activity. It has been implicated as a cancer-testis antigen and as a cancer stem-like cell antigen involved in renal cell carcinoma. [provided by RefSeq, Jun 2012]

GeneCards Summary for DNAJB8 Gene

DNAJB8 (DnaJ Heat Shock Protein Family (Hsp40) Member B8) is a Protein Coding gene. GO annotations related to this gene include unfolded protein binding and protein binding involved in protein folding. An important paralog of this gene is DNAJB6.

UniProtKB/Swiss-Prot for DNAJB8 Gene

  • Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB8 Gene

Genomics for DNAJB8 Gene

Regulatory Elements for DNAJB8 Gene

Enhancers for DNAJB8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G128407 2 FANTOM5 Ensembl ENCODE dbSUPER 19.4 +54.1 54121 10.7 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 ZNF766 FOS KLF13 DEK GATA2 DNAJB8 H1FX-AS1 DNAJB8-AS1 RPL32P3 EEFSEC LINC01565 GC03M128409 GC03P128380
GH03G128496 1.8 FANTOM5 Ensembl ENCODE dbSUPER 19.4 -30.0 -30013 2.2 HDGF AGO1 SIN3A ZNF48 YY1 TCF12 GATA2 ZNF263 ZHX2 REST DNAJB8 GATA2 DNAJB8-AS1 LINC01565 GATA2-AS1 TMED10P2 ABTB1 EEFSEC LOC90246
GH03G128431 2 FANTOM5 Ensembl ENCODE dbSUPER 12.6 +33.0 33038 4.7 PKNOX1 FOXA2 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 DNAJB8-AS1 ISY1 DNAJB8 ENSG00000244932 EEFSEC H1FX RPL32P3 LINC01565 H1FX-AS1 RUVBL1
GH03G128495 1.4 FANTOM5 ENCODE dbSUPER 15.7 -28.4 -28414 0.9 HDAC1 HDGF SUZ12 NFRKB TAL1 CDC5L ZNF48 TCF12 POLR2A GATA2 GATA2 DNAJB8 DNAJB8-AS1 EEFSEC LOC90246
GH03G128616 1.7 FANTOM5 Ensembl ENCODE 12.5 -151.3 -151315 4.8 HDGF PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 ZNF766 ZNF143 ZNF207 FOS GP9 POU5F1P6 DNAJB8 RPN1 GATA2 RAB7A KIAA1257 GC03P128663 LINC01565
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DNAJB8 on UCSC Golden Path with GeneCards custom track

Genomic Location for DNAJB8 Gene

Chromosome:
3
Start:
128,462,432 bp from pter
End:
128,467,248 bp from pter
Size:
4,817 bases
Orientation:
Minus strand

Genomic View for DNAJB8 Gene

Genes around DNAJB8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJB8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB8 Gene

Proteins for DNAJB8 Gene

  • Protein details for DNAJB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHS0-DNJB8_HUMAN
    Recommended name:
    DnaJ homolog subfamily B member 8
    Protein Accession:
    Q8NHS0
    Secondary Accessions:
    • B3KWV7

    Protein attributes for DNAJB8 Gene

    Size:
    232 amino acids
    Molecular mass:
    25686 Da
    Quaternary structure:
    • Interacts with histone deacetylases HDAC4, HDAC6, and SIRT2, HDAC activity is required for antiaggregation.

    Three dimensional structures from OCA and Proteopedia for DNAJB8 Gene

neXtProt entry for DNAJB8 Gene

Post-translational modifications for DNAJB8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJB8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJB8 Gene

Domains & Families for DNAJB8 Gene

Gene Families for DNAJB8 Gene

Protein Domains for DNAJB8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DNAJB8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHS0

UniProtKB/Swiss-Prot:

DNJB8_HUMAN :
  • The antiaggregation activity resides in the serine-rich region and the C-terminus.
Domain:
  • The antiaggregation activity resides in the serine-rich region and the C-terminus.
genes like me logo Genes that share domains with DNAJB8: view

Function for DNAJB8 Gene

Molecular function for DNAJB8 Gene

UniProtKB/Swiss-Prot Function:
Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins.

Gene Ontology (GO) - Molecular Function for DNAJB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044183 protein binding involved in protein folding IDA 23612975
GO:0051082 unfolded protein binding IDA 21231916
GO:0051087 chaperone binding IPI 21231916
genes like me logo Genes that share ontologies with DNAJB8: view
genes like me logo Genes that share phenotypes with DNAJB8: view

Animal Model Products

CRISPR Products

miRNA for DNAJB8 Gene

miRTarBase miRNAs that target DNAJB8

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJB8 Gene

Localization for DNAJB8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJB8 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DNAJB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21231916
GO:0005829 cytosol IDA 21231916
genes like me logo Genes that share ontologies with DNAJB8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DNAJB8 Gene

Pathways & Interactions for DNAJB8 Gene

SuperPathways for DNAJB8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0061077 chaperone-mediated protein folding IDA 23612975
GO:0090084 negative regulation of inclusion body assembly IDA 21231916
genes like me logo Genes that share ontologies with DNAJB8: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJB8 Gene

Transcripts for DNAJB8 Gene

mRNA/cDNA for DNAJB8 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DNAJB8 Gene

DnaJ (Hsp40) homolog, subfamily B, member 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB8 Gene

ExUns: 1a · 1b ^ 2 ^ 3
SP1:
SP2:

Relevant External Links for DNAJB8 Gene

GeneLoc Exon Structure for
DNAJB8
ECgene alternative splicing isoforms for
DNAJB8

Expression for DNAJB8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJB8 Gene

mRNA differential expression in normal tissues according to GTEx for DNAJB8 Gene

This gene is overexpressed in Testis (x52.4).

Protein differential expression in normal tissues from HIPED for DNAJB8 Gene

This gene is overexpressed in Ovary (33.4), Brain (16.6), Urine (11.3), and Testis (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNAJB8 Gene



Protein tissue co-expression partners for DNAJB8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJB8 Gene:

DNAJB8

SOURCE GeneReport for Unigene cluster for DNAJB8 Gene:

Hs.518241
genes like me logo Genes that share expression patterns with DNAJB8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJB8 Gene

Orthologs for DNAJB8 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAJB8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJB8 34 35
  • 99.14 (n)
dog
(Canis familiaris)
Mammalia DNAJB8 34 35
  • 86.21 (n)
cow
(Bos Taurus)
Mammalia DNAJB8 34 35
  • 84.99 (n)
oppossum
(Monodelphis domestica)
Mammalia DNAJB8 35
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajb8 34
  • 78.55 (n)
mouse
(Mus musculus)
Mammalia Dnajb8 34 16 35
  • 75.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJB8 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJB8 35
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJB8 35
  • 62 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:152986 35
  • 29 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta mrj 35
  • 28 (a)
OneToMany
Species where no ortholog for DNAJB8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAJB8 Gene

ENSEMBL:
Gene Tree for DNAJB8 (if available)
TreeFam:
Gene Tree for DNAJB8 (if available)

Paralogs for DNAJB8 Gene

(10) SIMAP similar genes for DNAJB8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DNAJB8: view

Variants for DNAJB8 Gene

Sequence variations from dbSNP and Humsavar for DNAJB8 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000133636 -- 128,468,796(+) GAGTG(G/T)ATGGG intron-variant, upstream-variant-2KB
rs1000551043 -- 128,462,236(+) TGGGT(C/T)TGAGG downstream-variant-500B, upstream-variant-2KB
rs1000555678 -- 128,464,411(+) GGCCC(C/T)ACTAA intron-variant
rs1000588358 -- 128,464,656(+) CTCCA(A/G)TTAAG intron-variant
rs1001288816 -- 128,469,088(+) AGACA(C/G)ATGAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DNAJB8 Gene

Variant ID Type Subtype PubMed ID
dgv8565n54 CNV loss 21841781
esv2759176 CNV loss 17122850
nsv470905 CNV loss 18288195
nsv508240 CNV deletion 20534489
nsv516926 CNV loss 19592680

Variation tolerance for DNAJB8 Gene

Residual Variation Intolerance Score: 67.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJB8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJB8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJB8 Gene

Disorders for DNAJB8 Gene

Relevant External Links for DNAJB8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJB8

No disorders were found for DNAJB8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJB8 Gene

Publications for DNAJB8 Gene

  1. A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation. (PMID: 20159555) Hageman J. … Kampinga H.H. (Mol. Cell 2010) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Heat shock protein DNAJB8 is a novel target for immunotherapy of colon cancer-initiating cells. (PMID: 24450541) Morita R. … Sato N. (Cancer Sci. 2014) 3 64
  5. Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. (PMID: 24823311) Guan W. … Steffen L.M. (Circ Cardiovasc Genet 2014) 3 64

Products for DNAJB8 Gene

Sources for DNAJB8 Gene

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