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DNAJB8 Gene

protein-coding   GIFtS: 48
GCID: GC03M128181

DnaJ (Hsp40) Homolog, Subfamily B, Member 8

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DnaJ (Hsp40) Homolog, Subfamily B, Member 81 2
DJ62 5
CT1562
DnaJ Homolog Subfamily B Member 82

External Ids:    HGNC: 236991   Entrez Gene: 1657212   Ensembl: ENSG000001794077   OMIM: 6113375   UniProtKB: Q8NHS03   

Export aliases for DNAJB8 gene to outside databases

Previous GC identifers: GC03M129502 GC03M129663 GC03M125565


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNAJB8 Gene:
The protein encoded by this gene belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity.
This family member suppresses aggregation and toxicity of polyglutamine proteins, and the C-terminal tail is
essential for this activity. It has been implicated as a cancer-testis antigen and as a cancer stem-like cell
antigen involved in renal cell carcinoma. (provided by RefSeq, Jun 2012)

GeneCards Summary for DNAJB8 Gene:
DNAJB8 (DnaJ (Hsp40) homolog, subfamily B, member 8) is a protein-coding gene. Diseases associated with DNAJB8 include renal cell carcinoma. GO annotations related to this gene include protein binding involved in protein folding. An important paralog of this gene is DNAJB4.

UniProtKB/Swiss-Prot: DNJB8_HUMAN, Q8NHS0
Function: Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNAJB8 gene promoter:
         E2F-4   E2F-3a   E2F-5   p300   E2F-2   POU3F2   Evi-1   c-Ets-1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNAJB8 promoter sequence
   Search Chromatin IP Primers for DNAJB8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNAJB8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.3   Ensembl cytogenetic band:  3q21.3   HGNC cytogenetic band: 3q21.3

DNAJB8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNAJB8 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M128181:  view genomic region     (about GC identifiers)

Start:
128,181,282 bp from pter      End:
128,186,091 bp from pter
Size:
4,810 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DNJB8_HUMAN, Q8NHS0 (See protein sequence)
Recommended Name: DnaJ homolog subfamily B member 8  
Size: 232 amino acids; 25686 Da
Subunit: Interacts with histone deacetylases HDAC4, HDAC6, and SIRT2, HDAC activity is required for
antiaggregation
1 PDB 3D structure from and Proteopedia for DNAJB8:
2DMX (3D)    
Secondary accessions: B3KWV7

Explore the universe of human proteins at neXtProt for DNAJB8: NX_Q8NHS0

Explore proteomics data for DNAJB8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DNAJB8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_699161.1  
    ENSEMBL proteins: 
     ENSP00000417418   ENSP00000316053  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    2 InterPro protein domains:
     IPR001623 DnaJ_domain
     IPR018253 DnaJ_domain_CS

    Graphical View of Domain Structure for InterPro Entry Q8NHS0

    ProtoNet protein and cluster: Q8NHS0

    UniProtKB/Swiss-Prot: DNJB8_HUMAN, Q8NHS0
    Domain: The antiaggregation activity resides in the serine-rich region and the C-terminus
    Similarity: Contains 1 J domain


    DNAJB8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DNJB8_HUMAN, Q8NHS0
    Function: Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0044183protein binding involved in protein folding IDA--
         
    DNAJB8 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DNAJB8:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
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    miRTarBase miRNAs that target DNAJB8:
    hsa-mir-128-3p (MIRT021945)

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    1 qRT-PCR Assays for microRNA that regulate DNAJB8:
    hsa-miR-3680
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    extracellular1
    mitochondrion1
    nucleus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including DNAJB8: 
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DNAJB8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for DNAJB8 (Q8NHS03 ENSP000003160534) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC4P565243, ENSP000002646064I2D: score=1 STRING: ENSP00000264606
    HDAC6Q9UBN73, ENSP000003340614I2D: score=1 STRING: ENSP00000334061
    SIRT2Q8IXJ63, ENSP000002493964I2D: score=1 STRING: ENSP00000249396
    RAE1ENSP000003602864STRING: ENSP00000360286
    CLPBENSP000002940534STRING: ENSP00000294053
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0061077chaperone-mediated protein folding IDA--

    DNAJB8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNAJB8 (DNJB8)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DNAJB8 gene: 
    NM_153330.4  

    Unigene Cluster for DNAJB8:

    DnaJ (Hsp40) homolog, subfamily B, member 8
    Hs.518241  [show with all ESTs]
    Unigene Representative Sequence: BC050288
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469083 ENST00000319153(uc003ekk.1)
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate DNAJB8:
    hsa-miR-3680
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    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat DNAJB8
      QuantiFast Probe-based Assays in human, mouse, rat DNAJB8

    Additional mRNA sequence: 

    AK126068.1 BC029521.1 BC050288.1 

    2 DOTS entries:

    DT.101979932  DT.305206 

    21 AceView cDNA sequences:

    AK126068 NM_153330 AI219830 BI830574 BX094760 AI188219 BC029521 BQ429043 
    BI825930 BC050288 AK125946 BI463059 BI560900 AI638044 BI825879 BI559505 
    BI829319 AA453265 AA453366 AA983750 BE041576 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB8    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for DNAJB8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNAJB8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DNAJB8 Expression
    About this image

    DNAJB8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNAJB8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.518241
        Pathway & Disease-focused RT2 Profiler PCR Array including DNAJB8: 
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNAJB8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DNAJB8 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnajb81 , 5 DnaJ (Hsp40) homolog, subfamily B, member 81, 5 75.96(n)1
    80.97(a)1
      6 (39.25 cM)5
    566911  NM_019964.11  NP_064348.11 
     882222685 
    chicken
    (Gallus gallus)
    Aves DNAJB86
    DnaJ (Hsp40) homolog, subfamily B, member 8
    50(a)
    1 ↔ 1
    12(9245863-9246974)
    lizard
    (Anolis carolinensis)
    Reptilia DNAJB86
    DnaJ (Hsp40) homolog, subfamily B, member 8
    62(a)
    1 ↔ 1
    2(165107267-165108399)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1529866
    zgc:152986
    29(a)
    many ↔ many
    6(40398426-40401385) ENSDARG00000070611
    fruit fly
    (Drosophila melanogaster)
    Insecta mrj6
    mrj
    28(a)
    1 → many
    2R(12090834-12109298)


    ENSEMBL Gene Tree for DNAJB8 (if available)
    TreeFam Gene Tree for DNAJB8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNAJB8 gene
    DNAJB42  DNAJB52  DNAJB132  DNAJB22  DNAJB92  DNAJB62  DNAJB12  DNAJB72  
    DNAJC5B2  DNAJC52  DNAJC5G2  
    10 SIMAP similar genes for DNAJB8 using alignment to 1 protein entry:     DNJB8_HUMAN:
    DNAJB6    DNAJB3    DNAJA4    DNAJB7    DNAJB2    DNAJA1
    DNAJB13    DNAJB4    DNAJB1    DNAJB5

    DNAJB8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for DNAJB8    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs359485111,2,4
    ----see VAR_0338812 mis40--------

    HapMap Linkage Disequilibrium report for DNAJB8 (128181282 - 128186091 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for DNAJB8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv516926CNV Loss19592680
    dgv5250n71CNV Loss21882294
    nsv470905CNV Loss18288195
    nsv877464CNV Loss21882294
    nsv508240CNV Loss20534489
    dgv1494e1CNV Complex17122850
    dgv1493e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNAJB8
    DNA2.0 Custom Variant and Variant Library Synthesis for DNAJB8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611337    OMIM disorders: --

    1 disease for DNAJB8:    
    About MalaCards
    renal cell carcinoma


    DNAJB8 for disorders           About GeneDecksing


    Export disorders for DNAJB8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNAJB8 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with DNAJB8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation. (PubMed id 20159555)1, 2 Hageman J.... Kampinga H.H. (Mol. Cell 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The DNAJB6 and DNAJB8 protein chaperones prevent intracellular aggregation of polyglutamine peptides. (PubMed id 23612975)1 Gillis J....Reits E.A. (J. Biol. Chem. 2013)
    4. HSP DNAJB8 controls tumor-initiating ability in renal cancer stem-like cells. (PubMed id 22552285)1 Nishizawa S....Sato N. (Cancer Res. 2012)
    5. Co-chaperones are limiting in a depleted chaperone network. (PubMed id 20556630)1 Heldens L....Lubsen N.H. (Cell. Mol. Life Sci. 2010)
    6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PubMed id 11147971)1 Ohtsuka K. and Hata M. (Cell Stress Chaperones 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 165721 HGNC: 23699 AceView: DNAJB8 Ensembl:ENSG00000179407 euGenes: HUgn165721
    ECgene: DNAJB8 H-InvDB: DNAJB8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DNAJB8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNAJB8 gene:
    Search GeneIP for patents involving DNAJB8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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