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Aliases for DNAJB7 Gene

Aliases for DNAJB7 Gene

  • DnaJ (Hsp40) Homolog, Subfamily B, Member 7 2 3
  • HSC3 3 4
  • Novel DnaJ Domain Protein 3
  • DJ5 3

External Ids for DNAJB7 Gene

Previous GeneCards Identifiers for DNAJB7 Gene

  • GC22M039499
  • GC22M039501
  • GC22M039581
  • GC22M041255
  • GC22M024217

Summaries for DNAJB7 Gene

Entrez Gene Summary for DNAJB7 Gene

  • The protein encoded by this intronless gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain.[provided by RefSeq, Mar 2011]

GeneCards Summary for DNAJB7 Gene

DNAJB7 (DnaJ (Hsp40) Homolog, Subfamily B, Member 7) is a Protein Coding gene. Diseases associated with DNAJB7 include oral cavity cancer. GO annotations related to this gene include chaperone binding. An important paralog of this gene is DNAJC5.

UniProtKB/Swiss-Prot for DNAJB7 Gene

  • Probably acts as a co-chaperone.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB7 Gene

Genomics for DNAJB7 Gene

Regulatory Elements for DNAJB7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DNAJB7 Gene

Chromosome:
22
Start:
40,859,549 bp from pter
End:
40,862,126 bp from pter
Size:
2,578 bases
Orientation:
Minus strand

Genomic View for DNAJB7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB7 Gene

Proteins for DNAJB7 Gene

  • Protein details for DNAJB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6W7-DNJB7_HUMAN
    Recommended name:
    DnaJ homolog subfamily B member 7
    Protein Accession:
    Q7Z6W7
    Secondary Accessions:
    • Q2M220
    • Q5H904
    • Q8WYJ7

    Protein attributes for DNAJB7 Gene

    Size:
    309 amino acids
    Molecular mass:
    35434 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DNAJB7 Gene

Proteomics data for DNAJB7 Gene at MOPED

Post-translational modifications for DNAJB7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJB7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DNAJB7 Gene

Domains & Families for DNAJB7 Gene

Gene Families for DNAJB7 Gene

Protein Domains for DNAJB7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DNAJB7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z6W7

UniProtKB/Swiss-Prot:

DNJB7_HUMAN :
  • Contains 1 J domain.
Domain:
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJB7: view

Function for DNAJB7 Gene

Molecular function for DNAJB7 Gene

UniProtKB/Swiss-Prot Function:
Probably acts as a co-chaperone.

Gene Ontology (GO) - Molecular Function for DNAJB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051087 chaperone binding IPI 21231916
genes like me logo Genes that share ontologies with DNAJB7: view

Phenotypes for DNAJB7 Gene

genes like me logo Genes that share phenotypes with DNAJB7: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJB7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DNAJB7 Gene

Localization for DNAJB7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJB7 Gene COMPARTMENTS Subcellular localization image for DNAJB7 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytoskeleton 1
cytosol 1
extracellular 1
plasma membrane 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DNAJB7 Gene

Pathways & Interactions for DNAJB7 Gene

SuperPathways for DNAJB7 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Heat Shock Proteins & Chaperones in human,mouse,rat

Interacting Proteins for DNAJB7 Gene

Gene Ontology (GO) - Biological Process for DNAJB7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DNAJB7 Gene

Drugs & Compounds for DNAJB7 Gene

No Compound Related Data Available

Transcripts for DNAJB7 Gene

mRNA/cDNA for DNAJB7 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DNAJB7 Gene

DnaJ (Hsp40) homolog, subfamily B, member 7:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNAJB7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB7 Gene

No ASD Table

Relevant External Links for DNAJB7 Gene

GeneLoc Exon Structure for
DNAJB7
ECgene alternative splicing isoforms for
DNAJB7

Expression for DNAJB7 Gene

mRNA expression in normal human tissues for DNAJB7 Gene

Protein differential expression in normal tissues from HIPED for DNAJB7 Gene

This gene is overexpressed in Fetal gut (30.4) and Pancreas (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DNAJB7 Gene



SOURCE GeneReport for Unigene cluster for DNAJB7 Gene Hs.585042

genes like me logo Genes that share expression patterns with DNAJB7: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DNAJB7 Gene

Orthologs for DNAJB7 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAJB7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNAJB7 35
  • 83.72 (n)
  • 78.74 (a)
DNAJB7 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJB7 35
  • 85.34 (n)
  • 78.5 (a)
DNAJB7 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajb7 35
  • 79.65 (n)
  • 73.68 (a)
Dnajb7 16
Dnajb7 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DNAJB7 35
  • 98.81 (n)
  • 98.06 (a)
DNAJB7 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajb7 35
  • 80.63 (n)
  • 70.4 (a)
oppossum
(Monodelphis domestica)
Mammalia DNAJB7 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
OneToMany
chicken
(Gallus gallus)
Aves DNAJB6 36
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii dnajb6a 36
  • 37 (a)
ManyToMany
dnajb6b 36
  • 41 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta mrj 36
  • 25 (a)
OneToMany
Species with no ortholog for DNAJB7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAJB7 Gene

ENSEMBL:
Gene Tree for DNAJB7 (if available)
TreeFam:
Gene Tree for DNAJB7 (if available)

Paralogs for DNAJB7 Gene

(4) SIMAP similar genes for DNAJB7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DNAJB7: view

Variants for DNAJB7 Gene

Sequence variations from dbSNP and Humsavar for DNAJB7 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
VAR_017779 -

Variation tolerance for DNAJB7 Gene

Residual Variation Intolerance Score: 74.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.52; 64.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJB7 Gene

HapMap Linkage Disequilibrium report
DNAJB7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DNAJB7 Gene

Disorders for DNAJB7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DNAJB7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
oral cavity cancer
  • malignant tumor of the floor of the mouth
- elite association

Relevant External Links for DNAJB7

Genetic Association Database (GAD)
DNAJB7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJB7
genes like me logo Genes that share disorders with DNAJB7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNAJB7 Gene

Publications for DNAJB7 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities. (PMID: 21231916) Hageman J. … Kampinga H.H. (Biochem. J. 2011) 67
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 67

Products for DNAJB7 Gene

Sources for DNAJB7 Gene

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