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Aliases for DNAJB7 Gene

Aliases for DNAJB7 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member B7 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily B, Member 7 2 3
  • HSC3 3 4
  • DnaJ Homolog Subfamily B Member 7 3
  • Novel DnaJ Domain Protein 3
  • DJ5 3

External Ids for DNAJB7 Gene

Previous GeneCards Identifiers for DNAJB7 Gene

  • GC22M039499
  • GC22M039501
  • GC22M039581
  • GC22M041255
  • GC22M024217

Summaries for DNAJB7 Gene

Entrez Gene Summary for DNAJB7 Gene

  • The protein encoded by this intronless gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain.[provided by RefSeq, Mar 2011]

GeneCards Summary for DNAJB7 Gene

DNAJB7 (DnaJ Heat Shock Protein Family (Hsp40) Member B7) is a Protein Coding gene. Diseases associated with DNAJB7 include Oral Cavity Cancer. GO annotations related to this gene include chaperone binding. An important paralog of this gene is DNAJB6.

UniProtKB/Swiss-Prot for DNAJB7 Gene

  • Probably acts as a co-chaperone.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJB7 Gene

Genomics for DNAJB7 Gene

Regulatory Elements for DNAJB7 Gene

Enhancers for DNAJB7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G041559 1.6 Ensembl ENCODE dbSUPER 20.2 -701.0 -700957 6.9 HDGF PKNOX1 ZFP64 ARID4B ZNF302 ZNF143 FOS ZNF263 SP3 ZNF662 EP300 XRCC6 PHF5A MEI1 POLR3H DNAJB7 CSDC2 TOB2 DESI1 SNU13
GH22G041815 1.1 ENCODE dbSUPER 20.2 -955.4 -955438 3.9 ZNF493 ZFP64 ZNF121 GATA2 ZNF138 ZNF354C ZNF654 ZNF680 ZNF426 OVOL3 EP300 RPL5P34 PHF5A RN7SKP80 MEI1 XRCC6 DNAJB7 TOB2 RRP7BP SNU13
GH22G041666 1.4 Ensembl ENCODE 10.8 -805.3 -805318 2.5 HDGF PKNOX1 FOXA2 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 RN7SKP80 EP300 PHF5A RRP7BP MEI1 EP300-AS1 XRCC6 LOC100313968 ENSG00000232754 SNU13
GH22G041474 1.1 ENCODE dbSUPER 10.8 -613.8 -613770 2.5 ZFP64 YY1 RELB IKZF2 ZNF654 ZNF680 ZNF426 CEBPB REST GATAD2B EP300 XRCC6 PHF5A SNU13 ENSG00000232754 ENSG00000235513 DNAJB7 XPNPEP3 POLR3H TEF
GH22G041271 0.8 ENCODE 10.8 -410.2 -410199 1.0 CTCF ZNF493 ZFP64 ZNF140 ZNF266 ZNF704 ZNF514 ZNF101 ZNF664 ZNF335 EP300 SNU13 ENSG00000235513 PHF5A DNAJB7 XPNPEP3 MIR6889 GC22M041806
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DNAJB7 on UCSC Golden Path with GeneCards custom track

Genomic Location for DNAJB7 Gene

40,859,549 bp from pter
40,862,126 bp from pter
2,578 bases
Minus strand

Genomic View for DNAJB7 Gene

Genes around DNAJB7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJB7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB7 Gene

Proteins for DNAJB7 Gene

  • Protein details for DNAJB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily B member 7
    Protein Accession:
    Secondary Accessions:
    • Q2M220
    • Q5H904
    • Q8WYJ7

    Protein attributes for DNAJB7 Gene

    309 amino acids
    Molecular mass:
    35434 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DNAJB7 Gene

Post-translational modifications for DNAJB7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJB7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJB7 Gene

Domains & Families for DNAJB7 Gene

Gene Families for DNAJB7 Gene

Protein Domains for DNAJB7 Gene


Suggested Antigen Peptide Sequences for DNAJB7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNAJB7: view

No data available for UniProtKB/Swiss-Prot for DNAJB7 Gene

Function for DNAJB7 Gene

Molecular function for DNAJB7 Gene

UniProtKB/Swiss-Prot Function:
Probably acts as a co-chaperone.

Gene Ontology (GO) - Molecular Function for DNAJB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051087 chaperone binding IPI 21231916
genes like me logo Genes that share ontologies with DNAJB7: view
genes like me logo Genes that share phenotypes with DNAJB7: view

Animal Models for DNAJB7 Gene

MGI Knock Outs for DNAJB7:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DNAJB7 Gene

Localization for DNAJB7 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJB7 gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 2
mitochondrion 2
plasma membrane 1
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DNAJB7 Gene

Pathways & Interactions for DNAJB7 Gene

SuperPathways for DNAJB7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJB7 Gene


No data available for Pathways by source and SIGNOR curated interactions for DNAJB7 Gene

Drugs & Compounds for DNAJB7 Gene

No Compound Related Data Available

Transcripts for DNAJB7 Gene

mRNA/cDNA for DNAJB7 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DNAJB7 Gene

DnaJ (Hsp40) homolog, subfamily B, member 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB7 Gene

No ASD Table

Relevant External Links for DNAJB7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJB7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJB7 Gene

Protein differential expression in normal tissues from HIPED for DNAJB7 Gene

This gene is overexpressed in Fetal gut (30.4) and Pancreas (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DNAJB7 Gene

NURSA nuclear receptor signaling pathways regulating expression of DNAJB7 Gene:


SOURCE GeneReport for Unigene cluster for DNAJB7 Gene:


Evidence on tissue expression from TISSUES for DNAJB7 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with DNAJB7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJB7 Gene

Orthologs for DNAJB7 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAJB7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DNAJB7 34 35
  • 98.81 (n)
(Canis familiaris)
Mammalia DNAJB7 34 35
  • 85.34 (n)
(Bos Taurus)
Mammalia DNAJB7 34 35
  • 83.72 (n)
(Rattus norvegicus)
Mammalia Dnajb7 34
  • 80.63 (n)
(Mus musculus)
Mammalia Dnajb7 34 16 35
  • 79.65 (n)
(Monodelphis domestica)
Mammalia DNAJB7 35
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 54 (a)
(Gallus gallus)
Aves DNAJB6 35
  • 53 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 55 (a)
(Danio rerio)
Actinopterygii dnajb6b 35
  • 41 (a)
dnajb6a 35
  • 37 (a)
fruit fly
(Drosophila melanogaster)
Insecta mrj 35
  • 25 (a)
Species where no ortholog for DNAJB7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAJB7 Gene

Gene Tree for DNAJB7 (if available)
Gene Tree for DNAJB7 (if available)

Paralogs for DNAJB7 Gene

(4) SIMAP similar genes for DNAJB7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DNAJB7: view

Variants for DNAJB7 Gene

Sequence variations from dbSNP and Humsavar for DNAJB7 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1002902048 -- 40,862,696(+) GAGAT(G/T)ATAGT intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1003247107 -- 40,861,521(+) TGTGA(A/T)GTATA intron-variant, reference, synonymous-codon
rs1004093756 -- 40,863,122(+) AAAGC(C/T)AGCAC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1004936576 -- 40,860,688(+) TACTT(C/T)GTCAC intron-variant, reference, synonymous-codon, utr-variant-3-prime
rs1005250864 -- 40,861,995(+) CCATG(-/T)TTTTA intron-variant, utr-variant-3-prime, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for DNAJB7 Gene

Variant ID Type Subtype PubMed ID
nsv1124863 CNV duplication 24896259

Variation tolerance for DNAJB7 Gene

Residual Variation Intolerance Score: 74.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.52; 64.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJB7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJB7 Gene

Disorders for DNAJB7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DNAJB7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
oral cavity cancer
  • malignant neoplasm of anterior portion of floor of mouth
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DNAJB7

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DNAJB7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNAJB7 Gene

Publications for DNAJB7 Gene

  1. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4 64
  5. The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities. (PMID: 21231916) Hageman J. … Kampinga H.H. (Biochem. J. 2011) 3 64

Products for DNAJB7 Gene

Sources for DNAJB7 Gene

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